{"id":751,"date":"2023-04-08T14:23:00","date_gmt":"2023-04-08T07:23:00","guid":{"rendered":"http:\/\/noithathoaphat.in\/ctv\/?p=751"},"modified":"2023-04-13T12:58:37","modified_gmt":"2023-04-13T05:58:37","slug":"the-barr-va-ung-dung-trong-y-hoc","status":"publish","type":"post","link":"http:\/\/noithathoaphat.in\/ctv\/index.php\/2023\/04\/08\/the-barr-va-ung-dung-trong-y-hoc\/","title":{"rendered":"Th\u1ec3 Barr v\u00e0 \u1ee9ng d\u1ee5ng trong y h\u1ecdc"},"content":{"rendered":"<p><strong>Khi t\u1ebf b\u00e0o c\u00f3 hai nhi\u1ec5m s\u1eafc th\u1ec3 X, m\u1ed9t nhi\u1ec5m s\u1eafc th\u1ec3 X s\u1ebd \u0111\u01b0\u1ee3c b\u1ea5t ho\u1ea1t v\u00e0 h\u00ecnh th\u00e0nh c\u1ea5u tr\u00fac g\u1ecdi l\u00e0 th\u1ec3 Barr. \u0110\u00e2y l\u00e0 m\u1ed9t c\u1ea5u tr\u00fac \u0111\u1eb7c bi\u1ec7t c\u00f3 t\u00ednh \u1ee9ng d\u1ee5ng cao trong ch\u1ea9n \u0111o\u00e1n y h\u1ecdc.<\/strong><\/p>\n<h4>1. Th\u1ec3 Barr l\u00e0 g\u00ec?<\/h4>\n<p><span style=\"font-weight: 400;\">Th\u1ec3 Barr l\u00e0 m\u1ed9t c\u01a1 ch\u1ebf \u0111i\u1ec1u ti\u1ebft t\u1ef1 \u0111\u1ed9ng c\u1ee7a vi\u1ec7c b\u1ea5t ho\u1ea1t nhi\u1ec5m s\u1eafc th\u1ec3 gi\u1edbi t\u00ednh trong c\u00e1c t\u1ebf b\u00e0o somatic c\u1ee7a n\u1eef gi\u1edbi. Khi m\u1ed9t t\u1ebf b\u00e0o n\u1eef c\u00f3 hai nhi\u1ec5m s\u1eafc th\u1ec3 X, ch\u1ec9 m\u1ed9t trong hai nhi\u1ec5m s\u1eafc th\u1ec3 X \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng \u0111\u1ec3 m\u00e3 h\u00f3a gen. Nhi\u1ec5m s\u1eafc th\u1ec3 X c\u00f2n l\u1ea1i \u0111\u01b0\u1ee3c b\u1ea5t ho\u1ea1t v\u00e0 h\u00ecnh th\u00e0nh th\u00e0nh m\u1ed9t c\u1ea5u tr\u00fac c\u00f3 t\u00ean l\u00e0 th\u1ec3 Barr. Th\u1ec3 Barr c\u00f3 \u1ee9ng d\u1ee5ng y h\u1ecdc trong vi\u1ec7c ch\u1ea9n \u0111o\u00e1n m\u1ed9t s\u1ed1 b\u1ec7nh li\u00ean quan \u0111\u1ebfn nhi\u1ec5m s\u1eafc th\u1ec3 X.<\/span><\/p>\n<figure id=\"attachment_756\" aria-describedby=\"caption-attachment-756\" style=\"width: 300px\" class=\"wp-caption aligncenter\"><img decoding=\"async\" loading=\"lazy\" class=\"wp-image-756 size-medium\" src=\"http:\/\/noithathoaphat.in\/ctv\/wp-content\/uploads\/2023\/04\/Screenshot-2023-04-04-at-22.16.58-300x223.png\" alt=\"\" width=\"300\" height=\"223\" srcset=\"http:\/\/noithathoaphat.in\/ctv\/wp-content\/uploads\/2023\/04\/Screenshot-2023-04-04-at-22.16.58-300x223.png 300w, http:\/\/noithathoaphat.in\/ctv\/wp-content\/uploads\/2023\/04\/Screenshot-2023-04-04-at-22.16.58-1024x760.png 1024w, http:\/\/noithathoaphat.in\/ctv\/wp-content\/uploads\/2023\/04\/Screenshot-2023-04-04-at-22.16.58-768x570.png 768w, http:\/\/noithathoaphat.in\/ctv\/wp-content\/uploads\/2023\/04\/Screenshot-2023-04-04-at-22.16.58.png 1302w\" sizes=\"(max-width: 300px) 100vw, 300px\" \/><figcaption id=\"caption-attachment-756\" class=\"wp-caption-text\">Minh h\u1ecda th\u1ec3 Barr<\/figcaption><\/figure>\n<p><span style=\"font-weight: 400;\">Th\u1ec3 Barr l\u00e0 m\u1ed9t c\u01a1 ch\u1ebf b\u1ea3o v\u1ec7 \u0111\u1ec3 \u0111\u1ea3m b\u1ea3o r\u1eb1ng c\u00e1c gen tr\u00ean nhi\u1ec5m s\u1eafc th\u1ec3 X ch\u1ec9 \u0111\u01b0\u1ee3c b\u1ed9 gen c\u1ee7a m\u1ed9t nhi\u1ec5m s\u1eafc th\u1ec3 X duy nh\u1ea5t bi\u1ec3u hi\u1ec7n. N\u00f3 c\u0169ng gi\u00fap gi\u1ea3i th\u00edch t\u1ea1i sao c\u00e1c b\u1ec7nh li\u00ean quan \u0111\u1ebfn nhi\u1ec5m s\u1eafc th\u1ec3 X th\u01b0\u1eddng x\u1ea3y ra \u1edf nam gi\u1edbi h\u01a1n l\u00e0 \u1edf n\u1eef gi\u1edbi.\u00a0<\/span><span style=\"font-weight: 400;\">Tuy nhi\u00ean, kh\u00f4ng ph\u1ea3i t\u1ea5t c\u1ea3 c\u00e1c t\u1ebf b\u00e0o n\u1eef gi\u1edbi \u0111\u1ec1u c\u00f3 th\u1ec3 Barr. Trong m\u1ed9t s\u1ed1 tr\u01b0\u1eddng h\u1ee3p, c\u00e1c t\u1ebf b\u00e0o somatic c\u1ee7a n\u1eef gi\u1edbi c\u00f3 th\u1ec3 kh\u00f4ng b\u1ea5t ho\u1ea1t nhi\u1ec5m s\u1eafc th\u1ec3 X v\u00e0 do \u0111\u00f3 kh\u00f4ng c\u00f3 th\u1ec3 Barr. \u0110i\u1ec1u n\u00e0y c\u00f3 th\u1ec3 x\u1ea3y ra trong tr\u01b0\u1eddng h\u1ee3p m\u1ed9t nhi\u1ec5m s\u1eafc th\u1ec3 X b\u1ecb xo\u00e1 ho\u1eb7c c\u00e1c \u0111\u1ed9t bi\u1ebfn kh\u00e1c trong qu\u00e1 tr\u00ecnh ph\u00e1t tri\u1ec3n t\u1ebf b\u00e0o.<\/span><\/p>\n<h4><strong>2. C\u00e1ch x\u00e1c \u0111\u1ecbnh th\u1ec3 Barr<\/strong><\/h4>\n<p>X\u00e1c \u0111\u1ecbnh th\u1ec3 Barr trong t\u1ebf b\u00e0o somatic (kh\u00f4ng ph\u1ea3i t\u1ebf b\u00e0o sinh d\u1ee5c) \u0111\u01b0\u1ee3c th\u1ef1c hi\u1ec7n b\u1eb1ng c\u00e1ch s\u1eed d\u1ee5ng c\u00e1c k\u1ef9 thu\u1eadt nhu\u1ed9m m\u00e0u v\u00e0 quan s\u00e1t b\u1eb1ng k\u00ednh hi\u1ec3n vi. C\u00e1c b\u01b0\u1edbc th\u1ef1c hi\u1ec7n bao g\u1ed3m:<\/p>\n<ul>\n<li><strong>Thu th\u1eadp m\u1eabu t\u1ebf b\u00e0o:<\/strong> M\u1eabu t\u1ebf b\u00e0o th\u01b0\u1eddng \u0111\u01b0\u1ee3c thu th\u1eadp t\u1eeb m\u1eabu m\u00e1u<\/li>\n<li><strong>Chu\u1ea9n b\u1ecb m\u1eabu t\u1ebf b\u00e0o:<\/strong> M\u1eabu t\u1ebf b\u00e0o \u0111\u01b0\u1ee3c chu\u1ea9n b\u1ecb b\u1eb1ng c\u00e1ch \u0111\u01b0a v\u00e0o m\u00f4i tr\u01b0\u1eddng nh\u01b0\u1ee3c tr\u01b0\u01a1ng \u0111\u1ec3 t\u1ebf b\u00e0o v\u1ee1 ra gi\u1ea3i ph\u00f3ng nhi\u1ec5m s\u1eafc th\u1ec3<\/li>\n<li><strong>Nhu\u1ed9m m\u1eabu t\u1ebf b\u00e0o:<\/strong> M\u1eabu t\u1ebf b\u00e0o \u0111\u01b0\u1ee3c nhu\u1ed9m b\u1eb1ng c\u00e1c ch\u1ea5t nhu\u1ed9m \u0111\u1eb7c bi\u1ec7t, ch\u1eb3ng h\u1ea1n nh\u01b0 Giemsa ho\u1eb7c Wright, \u0111\u1ec3 t\u0103ng t\u00ednh t\u01b0\u01a1ng ph\u1ea3n gi\u1eefa c\u00e1c c\u1ea5u tr\u00fac trong t\u1ebf b\u00e0o.<\/li>\n<li><strong>Quan s\u00e1t b\u1eb1ng k\u00ednh hi\u1ec3n vi:<\/strong> M\u1eabu t\u1ebf b\u00e0o \u0111\u01b0\u1ee3c quan s\u00e1t b\u1eb1ng k\u00ednh hi\u1ec3n vi \u0111\u1ec3 x\u00e1c \u0111\u1ecbnh s\u1ef1 hi\u1ec7n di\u1ec7n c\u1ee7a th\u1ec3 Barr. Th\u1ec3 Barr c\u00f3 h\u00ecnh d\u1ea1ng h\u00ecnh tam gi\u00e1c v\u00e0 c\u00f3 k\u00edch th\u01b0\u1edbc kho\u1ea3ng 0,5-1 micromet.<\/li>\n<\/ul>\n<p>Vi\u1ec7c x\u00e1c \u0111\u1ecbnh th\u1ec3 Barr c\u00f3 th\u1ec3 \u0111\u01b0\u1ee3c th\u1ef1c hi\u1ec7n trong ph\u00f2ng th\u00ed nghi\u1ec7m y t\u1ebf ho\u1eb7c b\u1edfi c\u00e1c chuy\u00ean gia v\u1ec1 di truy\u1ec1n h\u1ecdc ho\u1eb7c b\u00e1c s\u0129 di truy\u1ec1n. C\u00e1c k\u1ef9 thu\u1eadt m\u1edbi nh\u01b0 ph\u00e2n t\u00edch flow cytometry v\u00e0 ph\u00e1t hi\u1ec7n t\u1ef1 \u0111\u1ed9ng h\u00ecnh \u1ea3nh (automated image detection) c\u0169ng c\u00f3 th\u1ec3 \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng \u0111\u1ec3 x\u00e1c \u0111\u1ecbnh th\u1ec3 Barr.<\/p>\n<h4><strong>3. \u1ee8ng d\u1ee5ng c\u1ee7a th\u1ec3 Barr trong y h\u1ecdc<\/strong><\/h4>\n<p><span style=\"font-weight: 400;\">C\u00e1c \u1ee9ng d\u1ee5ng c\u1ee7a th\u1ec3 Barr trong y h\u1ecdc bao g\u1ed3m:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Ch\u1ea9n \u0111o\u00e1n <a href=\"https:\/\/www.vinmec.com\/vi\/tin-tuc\/thong-tin-suc-khoe\/chan-doan-va-dieu-tri-hoi-chung-turner-nao\/\">h\u1ed9i ch\u1ee9ng Turner<\/a>: H\u1ed9i ch\u1ee9ng Turner l\u00e0 m\u1ed9t b\u1ec7nh di truy\u1ec1n do thi\u1ebfu m\u1ed9t nhi\u1ec5m s\u1eafc th\u1ec3 X \u1edf n\u1eef gi\u1edbi. Vi\u1ec7c ki\u1ec3m tra th\u1ec3 Barr c\u00f3 th\u1ec3 \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng \u0111\u1ec3 x\u00e1c \u0111\u1ecbnh m\u1ed9t n\u1eef gi\u1edbi c\u00f3 m\u1ea5t m\u1ed9t nhi\u1ec5m s\u1eafc th\u1ec3 X hay kh\u00f4ng. \u1ede b\u1ec7nh nh\u00e2n Turner s\u1ebd kh\u00f4ng c\u00f3 th\u1ec3 Barr.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Ch\u1ea9n \u0111o\u00e1n h\u1ed9i ch\u1ee9ng Klinefelter: H\u1ed9i ch\u1ee9ng Klinefelter l\u00e0 m\u1ed9t b\u1ec7nh di truy\u1ec1n do c\u00f3 m\u1ed9t th\u1eeba nhi\u1ec5m s\u1eafc th\u1ec3 X \u1edf nam gi\u1edbi. Vi\u1ec7c ki\u1ec3m tra th\u1ec3 Barr c\u00f3 th\u1ec3 \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng \u0111\u1ec3 x\u00e1c \u0111\u1ecbnh m\u1ed9t nam gi\u1edbi c\u00f3 m\u1ed9t th\u1eeba nhi\u1ec5m s\u1eafc th\u1ec3 X hay kh\u00f4ng. B\u1ec7nh nh\u00e2n nam m\u1eafc h\u1ed9i ch\u1ee9ng Klinefelter s\u1ebd c\u00f3 1 th\u1ec3 Barr.\u00a0<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Ch\u1ea9n \u0111o\u00e1n c\u00e1c b\u1ec7nh li\u00ean quan \u0111\u1ebfn nhi\u1ec5m s\u1eafc th\u1ec3 X kh\u00e1c: Th\u1ec3 Barr c\u0169ng c\u00f3 th\u1ec3 \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng \u0111\u1ec3 ch\u1ea9n \u0111o\u00e1n c\u00e1c b\u1ec7nh li\u00ean quan \u0111\u1ebfn nhi\u1ec5m s\u1eafc th\u1ec3 X kh\u00e1c, nh\u01b0 h\u1ed9i ch\u1ee9ng Triple X, h\u1ed9i ch\u1ee9ng XYY, v\u00e0 c\u00e1c b\u1ec7nh li\u00ean quan \u0111\u1ebfn \u0111\u1ed9t bi\u1ebfn gen tr\u00ean nhi\u1ec5m s\u1eafc th\u1ec3 X.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\">Th\u1ec3 Barr c\u00f2n c\u00f3 th\u1ec3 \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng trong vi\u1ec7c \u0111i\u1ec1u tr\u1ecb ung th\u01b0 v\u00e0 \u0111\u00f3ng vai tr\u00f2 quan tr\u1ecdng trong x\u00e1c \u0111\u1ecbnh m\u1ee9c \u0111\u1ed9 b\u1ea5t th\u01b0\u1eddng c\u1ee7a c\u00e1c t\u1ebf b\u00e0o ung th\u01b0. Vi\u1ec7c ki\u1ec3m tra th\u1ec3 Barr c\u00f3 th\u1ec3 gi\u00fap \u0111\u01b0a ra ch\u1ea9n \u0111o\u00e1n, \u0111i\u1ec1u tr\u1ecb v\u00e0 ti\u00ean l\u01b0\u1ee3ng ph\u00f9 h\u1ee3p cho b\u1ec7nh nh\u00e2n.<\/li>\n<\/ul>\n","protected":false},"excerpt":{"rendered":"<p>Khi t\u1ebf b\u00e0o c\u00f3 hai nhi\u1ec5m s\u1eafc th\u1ec3 X, m\u1ed9t nhi\u1ec5m s\u1eafc th\u1ec3 X s\u1ebd \u0111\u01b0\u1ee3c b\u1ea5t ho\u1ea1t v\u00e0 h\u00ecnh th\u00e0nh c\u1ea5u tr\u00fac g\u1ecdi l\u00e0 th\u1ec3 Barr. \u0110\u00e2y l\u00e0 m\u1ed9t c\u1ea5u tr\u00fac \u0111\u1eb7c bi\u1ec7t c\u00f3 t\u00ednh \u1ee9ng d\u1ee5ng cao trong ch\u1ea9n \u0111o\u00e1n y h\u1ecdc. 1. Th\u1ec3 Barr l\u00e0 g\u00ec? Th\u1ec3 Barr l\u00e0 m\u1ed9t c\u01a1 ch\u1ebf [&hellip;]<\/p>\n","protected":false},"author":11,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[33,14],"tags":[3],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v20.4 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Th\u1ec3 Barr v\u00e0 \u1ee9ng d\u1ee5ng trong y h\u1ecdc - Vinmec<\/title>\n<meta name=\"description\" content=\"Khi t\u1ebf b\u00e0o c\u00f3 hai nhi\u1ec5m s\u1eafc th\u1ec3 X, m\u1ed9t nhi\u1ec5m s\u1eafc th\u1ec3 X s\u1ebd \u0111\u01b0\u1ee3c b\u1ea5t ho\u1ea1t v\u00e0 h\u00ecnh th\u00e0nh c\u1ea5u tr\u00fac th\u1ec3 Barr v\u1edbi t\u00ednh \u1ee9ng d\u1ee5ng y h\u1ecdc cao.\" \/>\n<meta name=\"robots\" content=\"noindex, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Th\u1ec3 Barr v\u00e0 \u1ee9ng d\u1ee5ng trong y h\u1ecdc - 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