{"id":35484,"date":"2023-06-23T14:57:53","date_gmt":"2023-06-23T07:57:53","guid":{"rendered":"http:\/\/noithathoaphat.in\/ctv\/?p=35484"},"modified":"2023-06-23T14:57:53","modified_gmt":"2023-06-23T07:57:53","slug":"tuong-tac-thuoc-giua-atorvastatin-va-gemfibrozil","status":"publish","type":"post","link":"http:\/\/noithathoaphat.in\/ctv\/index.php\/2023\/06\/23\/tuong-tac-thuoc-giua-atorvastatin-va-gemfibrozil\/","title":{"rendered":"T\u01b0\u01a1ng t\u00e1c thu\u1ed1c gi\u1eefa Atorvastatin v\u00e0 Gemfibrozil"},"content":{"rendered":"

Atorvastatin v\u00e0 Gemfibrozil l\u00e0 hai lo\u1ea1i thu\u1ed1c \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng r\u1ed9ng r\u00e3i \u0111\u1ec3 \u0111i\u1ec1u tr\u1ecb c\u00e1c v\u1ea5n \u0111\u1ec1 li\u00ean quan \u0111\u1ebfn m\u1ee1 m\u00e1u. Tuy nhi\u00ean, khi \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng \u0111\u1ed3ng th\u1eddi, hai lo\u1ea1i thu\u1ed1c n\u00e0y c\u00f3 th\u1ec3 t\u01b0\u01a1ng t\u00e1c v\u1edbi nhau v\u00e0 g\u00e2y ra nh\u1eefng t\u00e1c d\u1ee5ng ph\u1ee5 nguy hi\u1ec3m cho s\u1ee9c kh\u1ecfe. Trong b\u00e0i vi\u1ebft n\u00e0y, ch\u00fang ta s\u1ebd t\u00ecm hi\u1ec3u v\u1ec1 t\u01b0\u01a1ng t\u00e1c thu\u1ed1c gi\u1eefa Atorvastatin v\u00e0 Gemfibrozil, c\u01a1 ch\u1ebf t\u00e1c \u0111\u1ed9ng v\u00e0 c\u00e1ch qu\u1ea3n l\u00fd t\u01b0\u01a1ng t\u00e1c n\u00e0y \u0111\u1ec3 \u0111\u1ea3m b\u1ea3o an to\u00e0n cho b\u1ec7nh nh\u00e2n s\u1eed d\u1ee5ng c\u00e1c lo\u1ea1i thu\u1ed1c n\u00e0y.<\/b><\/p>\n

1.T\u1ed5ng quan v\u1ec1 thu\u1ed1c Atorvastatin\u00a0<\/b><\/h2>\n

Atorvastatin thu\u1ed9c nh\u00f3m thu\u1ed1c \u1ee9c ch\u1ebf men kh\u1eed HMG-CoA (<\/span>Statin<\/span><\/a>) l\u00e0 nh\u00f3m thu\u1ed1c h\u1ea1 lipid \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng trong ph\u00f2ng ng\u1eeba ti\u00ean ph\u00e1t v\u00e0 th\u1ee9 ph\u00e1t b\u1ec7nh tim m\u1ea1ch v\u00e0nh\u00a0<\/span><\/p>\n

\"Atorvastatin
Atorvastatin \u2013 nh\u00f3m Statin<\/figcaption><\/figure>\n

1.1 Ch\u1ec9 \u0111\u1ecbnh\u00a0<\/span><\/h3>\n

Atorvastatin <\/span><\/a>\u0111\u01b0\u1ee3c FDA ch\u1ea5p thu\u1eadn \u0111\u1ec3 ng\u0103n ng\u1eeba c\u00e1c bi\u1ebfn c\u1ed1 tim m\u1ea1ch \u1edf nh\u1eefng b\u1ec7nh nh\u00e2n c\u00f3 c\u00e1c y\u1ebfu t\u1ed1 nguy c\u01a1 tim m\u1ea1ch v\u00e0 c\u1ea3 nh\u1eefng b\u1ec7nh nh\u00e2n c\u00f3 c\u1ea5u h\u00ecnh lipid b\u1ea5t th\u01b0\u1eddng<\/span><\/p>\n

(1) Ph\u00f2ng ng\u1eeba ch\u00ednh: \u0110\u1ed1i v\u1edbi nh\u1eefng b\u1ec7nh nh\u00e2n kh\u00f4ng m\u1eafc b\u1ec7nh m\u1ea1ch v\u00e0nh nh\u01b0ng c\u00f3 nhi\u1ec1u y\u1ebfu t\u1ed1 nguy c\u01a1, Atorvastatin l\u00e0m gi\u1ea3m nguy c\u01a1 nh\u1ed3i m\u00e1u c\u01a1 tim, \u0111\u1ed9t qu\u1ef5, th\u1ee7 thu\u1eadt t\u00e1i t\u1ea1o m\u1ea1ch m\u00e1u v\u00e0 \u0111au th\u1eaft ng\u1ef1c. \u0110\u1ed1i v\u1edbi nh\u1eefng b\u1ec7nh nh\u00e2n m\u1eafc b\u1ec7nh \u0111\u00e1i th\u00e1o \u0111\u01b0\u1eddng tu\u00fdp 2 kh\u00f4ng c\u00f3 b\u1ec7nh m\u1ea1ch v\u00e0nh nh\u01b0ng c\u00f3 nhi\u1ec1u y\u1ebfu t\u1ed1 nguy c\u01a1, Atorvastatin c\u0169ng h\u1ed7 tr\u1ee3 <\/span>gi\u1ea3m nguy c\u01a1 nh\u1ed3i m\u00e1u c\u01a1 tim v\u00e0 \u0111\u1ed9t qu\u1ef5<\/span><\/p>\n

(2) Ph\u00f2ng ng\u1eeba th\u1ee9 c\u1ea5p: Atorvastatin \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng trong \u0111i\u1ec1u tr\u1ecb r\u1ed1i lo\u1ea1n lipid m\u00e1u (t\u0103ng Triglyceride m\u00e1u, r\u1ed1i lo\u1ea1n <\/span>-lipoprotein m\u00e1u nguy\u00ean ph\u00e1t, t\u0103ng Cholesterol m\u00e1u, \u2026)\u00a0<\/span><\/p>\n

1.2 C\u01a1 ch\u1ebf ho\u1ea1t \u0111\u1ed9ng\u00a0<\/span><\/h3>\n

Atorvastatin \u1ee9c ch\u1ebf c\u1ea1nh tranh 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase. B\u1eb1ng c\u00e1ch ng\u0103n ch\u1eb7n qu\u00e1 tr\u00ecnh chuy\u1ec3n \u0111\u1ed5i HMG-CoA th\u00e0nh Mevalonate, thu\u1ed1c l\u00e0m gi\u1ea3m s\u1ea3n xu\u1ea5t Cholesterol trong gan. Atorvastatin c\u0169ng l\u00e0m t\u0103ng s\u1ed1 l\u01b0\u1ee3ng th\u1ee5 th\u1ec3 LDL tr\u00ean b\u1ec1 m\u1eb7t t\u1ebf b\u00e0o gan. \u1ede nh\u1eefng b\u1ec7nh nh\u00e2n t\u0103ng Cholesterol m\u00e1u \u0111\u01b0\u1ee3c di truy\u1ec1n t\u1eeb gia \u0111\u00ecnh, b\u1ec7nh nh\u00e2n r\u1ed1i lo\u1ea1n lipid m\u00e1u h\u1ed7n h\u1ee3p, t\u0103ng Triglyceride m\u00e1u, Atorvastatin \u0111\u01b0\u1ee3c ch\u1ee9ng minh l\u00e0m gi\u1ea3m Cholesterol to\u00e0n ph\u1ea7n (TC), LDL-C v\u00e0 VLDL-C trong khi l\u00e0m t\u0103ng HDL-C. \u1ede nh\u1eefng b\u1ec7nh nh\u00e2n b\u1ecb r\u1ed1i lo\u1ea1n <\/span>-lipoprotein m\u00e1u, thu\u1ed1c c\u00f3 t\u00e1c d\u1ee5ng l\u00e0m gi\u1ea3m IDL-C<\/span><\/p>\n

1.3 Li\u1ec1u d\u00f9ng\u00a0<\/span><\/h3>\n

Atorvastatin c\u00f3 s\u1eb5n d\u01b0\u1edbi d\u1ea1ng vi\u00ean n\u00e9n v\u1edbi h\u00e0m l\u01b0\u1ee3ng l\u1ea7n l\u01b0\u1ee3t 10, 20, 40 v\u00e0 80mg<\/span><\/p>\n

Li\u1ec1u b\u00ecnh th\u01b0\u1eddng<\/span><\/p>\n

    \n
  • C\u01b0\u1eddng \u0111\u1ed9 trung b\u00ecnh: 10 \u2013 20mg<\/span><\/li>\n
  • C\u01b0\u1eddng \u0111\u1ed9 cao: 40 \u2013 80mg\u00a0<\/span><\/li>\n<\/ul>\n

    Li\u1ec1u cho ng\u01b0\u1eddi suy th\u1eadn: kh\u00f4ng c\u1ea7n \u0111i\u1ec1u ch\u1ec9nh li\u1ec1u khi ch\u1ee9c n\u0103ng suy th\u1eadn suy gi\u1ea3m v\u00ec Atorvastatin v\u00e0 c\u00e1c ch\u1ea5t chuy\u1ec3n h\u00f3a kh\u00f4ng th\u1ea3i tr\u1eeb qua th\u1eadn\u00a0<\/span><\/p>\n

    Li\u1ec1u cho ng\u01b0\u1eddi suy gan: n\u1ed3ng \u0111\u1ed9 Atorvastatin trong huy\u1ebft t\u01b0\u01a1ng t\u0103ng khi d\u00f9ng cho b\u1ec7nh nh\u00e2n m\u1eafc b\u1ec7nh gan m\u00e3n t\u00ednh do \u0111\u00f3 n\u00ean th\u1eadn tr\u1ecdng ho\u1eb7c c\u00e2n nh\u1eafc \u0111\u1ed5i thu\u1ed1c kh\u00e1c<\/span><\/p>\n

    1.4 T\u00e1c d\u1ee5ng ph\u1ee5\u00a0<\/span><\/h3>\n

    C\u00e1c t\u00e1c d\u1ee5ng ph\u1ee5 th\u01b0\u1eddng g\u1eb7p \u0111\u1ed1i v\u1edbi b\u1ec7nh nh\u00e2n d\u00f9ng Atorvastatin bao g\u1ed3m: \u0111au kh\u1edbp, kh\u00f3 ti\u00eau, ti\u00eau ch\u1ea3y, bu\u1ed3n n\u00f4n, vi\u00eam m\u0169i h\u1ecdng, m\u1ea5t ng\u1ee7, nhi\u1ec5m tr\u00f9ng \u0111\u01b0\u1eddng ti\u1ebft ni\u1ec7u v\u00e0 \u0111au t\u1ee9 chi<\/span><\/p>\n

    1.5 Ch\u1ed1ng ch\u1ec9 \u0111\u1ecbnh\u00a0<\/span><\/h3>\n

    Ch\u1ed1ng ch\u1ec9 \u0111\u1ecbnh c\u1ee7a Atorvastatin bao g\u1ed3m nh\u1eefng b\u1ec7nh nh\u00e2n qu\u00e1 m\u1eabn c\u1ea3m v\u1edbi b\u1ea5t k\u1ef3 th\u00e0nh ph\u1ea7n n\u00e0o c\u1ee7a thu\u1ed1c, trong th\u1eddi k\u1ef3 mang thai ho\u1eb7c \u1edf nh\u1eefng b\u1ec7nh nh\u00e2n n\u1eef c\u00f3 th\u1ec3 mang thai, ph\u1ee5 n\u1eef \u0111ang cho con b\u00fa\u00a0<\/span><\/p>\n

    2. Th\u00f4ng tin chung v\u1ec1 thu\u1ed1c Gemfibrozil<\/b><\/h2>\n

    Gemfibrozil l\u00e0 m\u1ed9t t\u00e1c nh\u00e2n Acid Fibric (Fibrate) \u0111\u00e3 \u0111\u01b0\u1ee3c FDA ch\u1ea5p thu\u1eadn \u0111\u1ec3 ki\u1ec3m so\u00e1t ch\u1ee9ng t\u0103ng triglycerid m\u00e1u (\u0111\u1eb7c bi\u1ec7t l\u00e0 trong t\u0103ng lipid m\u00e1u lo\u1ea1i IV v\u00e0 V) \u0111\u1eb7c bi\u1ec7t \u0111\u1ed1i v\u1edbi nh\u1eefng b\u1ec7nh nh\u00e2n kh\u00f4ng c\u00f3 \u0111\u00e1p \u1ee9ng \u0111i\u1ec1u tr\u1ecb \u0111\u1ea7y \u0111\u1ee7 v\u1edbi c\u00e1c bi\u1ec7n ph\u00e1p \u0103n ki\u00eang<\/span><\/p>\n

    \"Gemfibrozil
    Gemfibrozil \u2013 nh\u00f3m Fibrate<\/figcaption><\/figure>\n

    2.1 Ch\u1ec9 \u0111\u1ecbnh\u00a0<\/span><\/h3>\n

    Gemfibrozil l\u00e0 m\u1ed9t lo\u1ea1i thu\u1ed1c h\u1eefu \u00edch \u0111\u1ec3 gi\u1ea3m ch\u1ea5t b\u00e9o trung t\u00ednh \u1edf nh\u1eefng b\u1ec7nh nh\u00e2n c\u00f3 n\u1ed3ng \u0111\u1ed9 ch\u1ea5t b\u00e9o trung t\u00ednh trong huy\u1ebft thanh r\u1ea5t cao. Ngo\u00e0i ra, thu\u1ed1c c\u0169ng \u0111\u01b0\u1ee3c ch\u1ea5p thu\u1eadn \u0111\u1ec3 gi\u1ea3m nguy c\u01a1 ph\u00e1t tri\u1ec3n b\u1ec7nh tim m\u1ea1ch v\u00e0nh (Lo\u1ea1i IIb), \u0111\u1eb7c bi\u1ec7t \u1edf nh\u1eefng b\u1ec7nh nh\u00e2n kh\u00f4ng c\u00f3 ti\u1ec1n s\u1eed m\u1eafc c\u00e1c tri\u1ec7u ch\u1ee9ng b\u1ec7nh tim m\u1ea1ch v\u00e0nh. B\u00ean c\u1ea1nh \u0111\u00f3, Gemfibrozil c\u0169ng mang l\u1ea1i t\u00e1c d\u1ee5ng c\u00f3 l\u1ee3i cho nh\u1eefng b\u1ec7nh nh\u00e2n kh\u00f4ng \u0111\u00e1p \u1ee9ng \u0111\u1ea7y \u0111\u1ee7 v\u1edbi vi\u1ec7c gi\u1ea3m c\u00e2n, \u0111i\u1ec1u tr\u1ecb b\u1eb1ng ch\u1ebf \u0111\u1ed9 \u0103n ki\u00eang, t\u1eadp th\u1ec3 d\u1ee5c v\u00e0 c\u00e1c lo\u1ea1i thu\u1ed1c kh\u00e1c. M\u1ed9t s\u1ed1 th\u1eed nghi\u1ec7m l\u00e2m s\u00e0ng ch\u1ee9ng minh Gemfibrozil c\u00f3 th\u1ec3 \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng m\u1ed9t c\u00e1ch an to\u00e0n v\u00e0 c\u00f3 ti\u1ec1m n\u0103ng hi\u1ec7u qu\u1ea3 nh\u01b0 m\u1ed9t ph\u01b0\u01a1ng ph\u00e1p \u0111i\u1ec1u tr\u1ecb h\u1ed7 tr\u1ee3 cho tr\u1ebb em m\u1eafc b\u1ec7nh Lipofuscinose t\u1ebf b\u00e0o th\u1ea7n kinh mu\u1ed9n v\u00e0 c\u00e1c b\u1ec7nh t\u00edch tr\u1eef lipid kh\u00e1c<\/span><\/p>\n

    2.2 C\u01a1 ch\u1ebf ho\u1ea1t \u0111\u1ed9ng\u00a0<\/span><\/h3>\n

    Gemfibrozil ho\u1ea1t \u0111\u1ed9ng b\u1eb1ng c\u00e1ch k\u00edch ho\u1ea1t th\u1ee5 th\u1ec3 Alpha-Peroxisome proliferator-activated (PPAR-alpha) t\u1ea1o ra nh\u1eefng thay \u0111\u1ed5i trong qu\u00e1 tr\u00ecnh chuy\u1ec3n h\u00f3a Lipid, t\u1eeb \u0111\u00f3 l\u00e0m gi\u1ea3m m\u1ee9c ch\u1ea5t b\u00e9o trung t\u00ednh trong huy\u1ebft t\u01b0\u01a1ng v\u00e0 t\u0103ng lipoprotein m\u1eadt \u0111\u1ed9 cao (HDL). PPAR-alpha t\u1ea1o ra s\u1ef1 \u0111i\u1ec1u ch\u1ec9nh t\u0103ng c\u1ee7a lipoprotein lipase (LPL) trong m\u00f4 m\u1ee1 v\u00e0 c\u01a1, d\u1eabn \u0111\u1ebfn gi\u1ea3m m\u1ee9c ch\u1ea5t b\u00e9o trung t\u00ednh. Gemfibrozil \u1ee9c ch\u1ebf qu\u00e1 tr\u00ecnh ph\u00e2n gi\u1ea3i m\u1ee1 ngo\u1ea1i bi\u00ean v\u00e0 l\u00e0m gi\u1ea3m qu\u00e1 tr\u00ecnh lo\u1ea1i b\u1ecf c\u00e1c acid b\u00e9o t\u1ef1 do \u1edf gan, do \u0111\u00f3 l\u00e0m gi\u1ea3m s\u1ea3n xu\u1ea5t Triglyceride \u1edf gan<\/span><\/p>\n

    2.3 Li\u1ec1u l\u01b0\u1ee3ng\u00a0<\/span><\/h3>\n

    Gemfibrozil c\u00f3 s\u1eb5n \u1edf d\u1ea1ng vi\u00ean u\u1ed1ng 600mg\u00a0<\/span><\/p>\n

    Li\u1ec1u khuy\u1ebfn c\u00e1o cho ch\u1ee9ng t\u0103ng Triglyceride m\u00e1u l\u00e0 600mg\/12h v\u00e0 n\u00ean d\u00f9ng thu\u1ed1c 30 ph\u00fat tr\u01b0\u1edbc b\u1eefa \u0103n s\u00e1ng v\u00e0 t\u1ed1i\u00a0<\/span><\/p>\n

    Li\u1ec1u khuy\u1ebfn c\u00e1o t\u1ed1i \u0111a cho ng\u01b0\u1eddi l\u1edbn: 1200mg\/ng\u00e0y\u00a0<\/span><\/p>\n

    2.4 T\u00e1c d\u1ee5ng ph\u1ee5\u00a0<\/span><\/h3>\n

    C\u00e1c t\u00e1c d\u1ee5ng ph\u1ee5 th\u01b0\u1eddng g\u1eb7p trong qu\u00e1 tr\u00ecnh \u0111i\u1ec1u tr\u1ecb b\u1eb1ng thu\u1ed1c Gemfibrozil nh\u01b0 \u0111au b\u00e0ng quang, n\u01b0\u1edbc ti\u1ec3u c\u00f3 m\u00e1u ho\u1eb7c \u0111\u1ee5c m\u00e0u, ho ho\u1eb7c khan ti\u1ebfng, \u0111i ti\u1ec3u kh\u00f3 kh\u0103n, s\u1ed1t ho\u1eb7c \u1edbn l\u1ea1nh, th\u01b0\u1eddng xuy\u00ean mu\u1ed1n \u0111i ti\u1ec3u, \u0111au l\u01b0ng<\/span><\/p>\n

    2.5 Ch\u1ed1ng ch\u1ec9 \u0111\u1ecbnh\u00a0<\/span><\/h3>\n

    Kh\u00f4ng d\u00f9ng thu\u1ed1c Gemfibrozil bao g\u1ed3m c\u00e1c b\u1ec7nh nh\u00e2n r\u1ed1i lo\u1ea1n ch\u1ee9c n\u0103ng gan ho\u1eb7c th\u1eadn n\u1eb7ng, s\u1ecfi m\u1eadt, b\u1ea5t th\u01b0\u1eddng t\u00fai m\u1eadt, qu\u00e1 m\u1eabn c\u1ea3m<\/span><\/p>\n

    3. T\u01b0\u01a1ng t\u00e1c thu\u1ed1c gi\u1eefa Amiodaron v\u00e0 Gemfibrozil<\/b><\/h2>\n

    3.1 M\u1ee9c \u0111\u1ed9 t\u01b0\u01a1ng t\u00e1c t\u1eeb nhi\u1ec1u ngu\u1ed3n\u00a0<\/span><\/h3>\n

    Lexicomp: Nghi\u00eam tr\u1ecdng\u00a0<\/span><\/p>\n

    Micromedex: Nghi\u00eam tr\u1ecdng\u00a0<\/span><\/p>\n

    Drugs interaction: Nghi\u00eam tr\u1ecdng\u00a0<\/span><\/p>\n

    3.2 C\u01a1 ch\u1ebf t\u01b0\u01a1ng t\u00e1c thu\u1ed1c gi\u1eefa Amiodaron v\u00e0 Gemfibrozil<\/span><\/h3>\n

    T\u01b0\u01a1ng t\u00e1c thu\u1ed1c theo c\u01a1 ch\u1ebf t\u01b0\u01a1ng t\u00e1c d\u01b0\u1ee3c \u0111\u1ed9ng h\u1ecdc: Gemfibrozil \u1ee9c ch\u1ebf OATP1B1 l\u00e0m gi\u1ea3m v\u1eadn chuy\u1ec3n Atorvastatin v\u00e0o gan<\/span><\/p>\n

    3.3 H\u1eadu qu\u1ea3 t\u01b0\u01a1ng t\u00e1c thu\u1ed1c\u00a0<\/span><\/h3>\n

    T\u0103ng n\u1ed3ng \u0111\u1ed9 Atorvastatin trong huy\u1ebft thanh<\/span><\/p>\n

    T\u0103ng nguy c\u01a1 b\u1ec7nh c\u01a1 ho\u1eb7c ti\u00eau c\u01a1 v\u00e2n c\u1ea5p<\/span><\/p>\n

    3.4 C\u00e1ch x\u1eed tr\u00ed\u00a0<\/span><\/h3>\n

    Ch\u1ed1ng ch\u1ec9 \u0111\u1ecbnh ph\u1ed1i h\u1ee3p<\/span><\/p>\n

    Trong tr\u01b0\u1eddng h\u1ee3p b\u1eaft bu\u1ed9c s\u1eed d\u1ee5ng d\u1eabn ch\u1ea5t Fibrat, thay th\u1ebf Gemfibrozil b\u1eb1ng Fenofibrat nh\u01b0ng c\u1ea7n th\u1eadn tr\u1ecdng khi ph\u1ed1i h\u1ee3p.<\/span><\/p>\n

     <\/p>\n","protected":false},"excerpt":{"rendered":"

    Atorvastatin v\u00e0 Gemfibrozil l\u00e0 hai lo\u1ea1i thu\u1ed1c \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng r\u1ed9ng r\u00e3i \u0111\u1ec3 \u0111i\u1ec1u tr\u1ecb c\u00e1c v\u1ea5n \u0111\u1ec1 li\u00ean quan \u0111\u1ebfn m\u1ee1 m\u00e1u. Tuy nhi\u00ean, khi \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng \u0111\u1ed3ng th\u1eddi, hai lo\u1ea1i thu\u1ed1c n\u00e0y c\u00f3 th\u1ec3 t\u01b0\u01a1ng t\u00e1c v\u1edbi nhau v\u00e0 g\u00e2y ra nh\u1eefng t\u00e1c d\u1ee5ng ph\u1ee5 nguy hi\u1ec3m cho s\u1ee9c kh\u1ecfe. Trong b\u00e0i […]<\/p>\n","protected":false},"author":54,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[12],"tags":[],"yoast_head":"\nT\u01b0\u01a1ng t\u00e1c thu\u1ed1c gi\u1eefa Atorvastatin v\u00e0 Gemfibrozil - Vinmec<\/title>\n<meta name=\"description\" content=\"Atorvastatin v\u00e0 Gemfibrozil l\u00e0 hai lo\u1ea1i thu\u1ed1c \u0111i\u1ec1u tr\u1ecb c\u00e1c v\u1ea5n \u0111\u1ec1 li\u00ean quan \u0111\u1ebfn m\u1ee1 m\u00e1u. 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