{"id":35432,"date":"2023-06-22T14:04:47","date_gmt":"2023-06-22T07:04:47","guid":{"rendered":"http:\/\/noithathoaphat.in\/ctv\/?p=35432"},"modified":"2023-06-22T14:04:47","modified_gmt":"2023-06-22T07:04:47","slug":"lodoco-thuoc-khang-viem-dau-tien-giam-nguy-co-tim-mach","status":"publish","type":"post","link":"http:\/\/noithathoaphat.in\/ctv\/index.php\/2023\/06\/22\/lodoco-thuoc-khang-viem-dau-tien-giam-nguy-co-tim-mach\/","title":{"rendered":"Lodoco \u2013 Thu\u1ed1c kh\u00e1ng vi\u00eam \u0111\u1ea7u ti\u00ean gi\u1ea3m nguy c\u01a1 tim m\u1ea1ch"},"content":{"rendered":"<p><strong>T\u1eeb tr\u01b0\u1edbc \u0111\u1ebfn nay, b\u1ec7nh tim m\u1ea1ch \u0111\u00e3 tr\u1edf th\u00e0nh m\u1ed9t trong nh\u1eefng nguy\u00ean nh\u00e2n ch\u00ednh g\u00e2y t\u1eed vong tr\u00ean to\u00e0n th\u1ebf gi\u1edbi. V\u00e0 m\u1edbi \u0111\u00e2y, m\u1ed9t tin vui \u0111\u00e3 \u0111\u1ebfn v\u1edbi ng\u00e0nh y t\u1ebf khi C\u01a1 quan Qu\u1ea3n l\u00fd Th\u1ef1c ph\u1ea9m v\u00e0 D\u01b0\u1ee3c ph\u1ea9m Hoa K\u1ef3 (FDA) \u0111\u00e3 ph\u00ea duy\u1ec7t Lodoco &#8211; thu\u1ed1c kh\u00e1ng vi\u00eam \u0111\u1ea7u ti\u00ean c\u00f3 kh\u1ea3 n\u0103ng gi\u1ea3m nguy c\u01a1 tim m\u1ea1ch cho nh\u1eefng ng\u01b0\u1eddi b\u1ecb vi\u00eam m\u00e0ng c\u01a1 tim. \u0110i\u1ec1u n\u00e0y \u0111\u00e3 m\u1edf ra m\u1ed9t h\u01b0\u1edbng \u0111i m\u1edbi trong vi\u1ec7c ph\u00f2ng ng\u1eeba v\u00e0 \u0111i\u1ec1u tr\u1ecb c\u00e1c b\u1ec7nh tim m\u1ea1ch, \u0111\u1eb7c bi\u1ec7t l\u00e0 cho nh\u1eefng ng\u01b0\u1eddi c\u00f3 nguy c\u01a1 cao<\/strong><\/p>\n<h2><b>1.Gi\u1edbi thi\u1ec7u s\u01a1 l\u01b0\u1ee3c<\/b><\/h2>\n<p><span style=\"font-weight: 400;\">Lodoco c\u1ee7a c\u00f4ng ty AGEPHA Pharma \u0111\u00e3 \u0111\u01b0\u1ee3c C\u01a1 quan Qu\u1ea3n l\u00fd Th\u1ef1c ph\u1ea9m v\u00e0 D\u01b0\u1ee3c ph\u1ea9m Hoa K\u1ef3 (FDA) ch\u1ea5p thu\u1eadn \u0111\u1ec3 \u0111i\u1ec1u tr\u1ecb b\u1ec7nh tim m\u1ea1ch. Lodoco \u0111\u01b0\u1ee3c ch\u1ec9 \u0111\u1ecbnh \u0111\u1ec3 gi\u1ea3m nguy c\u01a1 \u0111\u1ed9t qu\u1ef5, nh\u1ed3i m\u00e1u c\u01a1 tim v\u00e0 t\u1eed vong do tim m\u1ea1ch \u1edf ng\u01b0\u1eddi l\u1edbn m\u1eafc b\u1ec7nh tim m\u1ea1ch do <a href=\"https:\/\/www.vinmec.com\/vi\/benh\/xo-vua-dong-mach-3030\/\">x\u01a1 v\u1eefa \u0111\u1ed9ng m\u1ea1ch<\/a> (ASCVD) ho\u1eb7c c\u00f3 nhi\u1ec1u y\u1ebfu t\u1ed1 nguy c\u01a1 m\u1eafc b\u1ec7nh. S\u1ef1 ch\u1ea5p thu\u1eadn theo quy \u0111\u1ecbnh d\u1ef1a tr\u00ean nh\u1eefng ph\u00e1t hi\u1ec7n thu \u0111\u01b0\u1ee3c t\u1eeb m\u1ed9t th\u1eed nghi\u1ec7m l\u00e2m s\u00e0ng ng\u1eabu nhi\u00ean, m\u00f9 \u0111\u00f4i, \u0111a qu\u1ed1c gia, c\u00f3 ki\u1ec3m so\u00e1t gi\u1ea3 d\u01b0\u1ee3c, \u0111\u01b0\u1ee3c ti\u1ebfn h\u00e0nh \u1edf 5.522 b\u1ec7nh nh\u00e2n m\u1eafc b\u1ec7nh m\u1ea1ch v\u00e0nh m\u1ea1n t\u00ednh (2762 \u0111\u1ed1i t\u01b0\u1ee3ng d\u00f9ng Lodoco v\u00e0 2760 \u0111\u1ed1i t\u01b0\u1ee3ng d\u00f9ng gi\u1ea3 d\u01b0\u1ee3c). Nh\u1eefng ng\u01b0\u1eddi tham gia \u0111\u01b0\u1ee3c \u0111i\u1ec1u tr\u1ecb b\u1eb1ng Lodoco \u0111\u00e3 gi\u1ea3m 31% nguy c\u01a1 t\u1eed vong do tim m\u1ea1ch, nh\u1ed3i m\u00e1u c\u01a1 tim t\u1ef1 ph\u00e1t ho\u1eb7c \u0111\u1ed9t qu\u1ef5 do thi\u1ebfu m\u00e1u c\u1ee5c b\u1ed9 khi \u0111\u01b0\u1ee3c b\u1ed5 sung th\u00eam statin v\u00e0 c\u00e1c li\u1ec7u ph\u00e1p ph\u00f2ng ng\u1eeba tim m\u1ea1ch kh\u00e1c, so v\u1edbi nh\u1eefng ng\u01b0\u1eddi \u0111\u01b0\u1ee3c \u0111i\u1ec1u tr\u1ecb b\u1eb1ng gi\u1ea3 d\u01b0\u1ee3c.<\/span><\/p>\n<h2><b>2.Th\u00f4ng tin v\u1ec1 thu\u1ed1c Lodoco<\/b><span style=\"font-weight: 400;\">\u00a0<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">Lodoco l\u00e0 thu\u1ed1c d\u1ea1ng vi\u00ean u\u1ed1ng, ch\u1ee9a th\u00e0nh ph\u1ea7n <a href=\"http:\/\/noithathoaphat.in\/ctv\/wp-admin\/post-new.php\">Colchicine<\/a>, l\u00e0 m\u1ed9t Alkaloid, do AGEPHA Pharma ph\u00e1t tri\u1ec3n v\u00e0 th\u01b0\u01a1ng m\u1ea1i h\u00f3a<\/span><\/p>\n<figure id=\"attachment_35433\" aria-describedby=\"caption-attachment-35433\" style=\"width: 300px\" class=\"wp-caption aligncenter\"><img decoding=\"async\" loading=\"lazy\" class=\"size-medium wp-image-35433\" src=\"http:\/\/noithathoaphat.in\/ctv\/wp-content\/uploads\/2023\/06\/Lodoco-\u2013-thuoc-khang-viem-tac-dung-giam-nguy-co-tim-mach-300x232.png\" alt=\"Lodoco \u2013 thu\u1ed1c kh\u00e1ng vi\u00eam t\u00e1c d\u1ee5ng gi\u1ea3m nguy c\u01a1 tim m\u1ea1ch\" width=\"300\" height=\"232\" srcset=\"http:\/\/noithathoaphat.in\/ctv\/wp-content\/uploads\/2023\/06\/Lodoco-\u2013-thuoc-khang-viem-tac-dung-giam-nguy-co-tim-mach-300x232.png 300w, http:\/\/noithathoaphat.in\/ctv\/wp-content\/uploads\/2023\/06\/Lodoco-\u2013-thuoc-khang-viem-tac-dung-giam-nguy-co-tim-mach.png 680w\" sizes=\"(max-width: 300px) 100vw, 300px\" \/><figcaption id=\"caption-attachment-35433\" class=\"wp-caption-text\">Lodoco \u2013 thu\u1ed1c kh\u00e1ng vi\u00eam t\u00e1c d\u1ee5ng gi\u1ea3m nguy c\u01a1 tim m\u1ea1ch<\/figcaption><\/figure>\n<h3><span style=\"font-weight: 400;\">2.1 Ch\u1ec9 \u0111\u1ecbnh v\u00e0 c\u00e1ch d\u00f9ng\u00a0<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">Lodoco \u0111\u01b0\u1ee3c ch\u1ec9 \u0111\u1ecbnh \u0111\u1ec3 gi\u1ea3m nguy c\u01a1 nh\u1ed3i m\u00e1u c\u01a1 tim (MI), \u0111\u1ed9t qu\u1ef5, t\u00e1i th\u00f4ng m\u1ea1ch v\u00e0nh v\u00e0 t\u1eed vong do tim m\u1ea1ch \u1edf b\u1ec7nh nh\u00e2n tr\u01b0\u1edfng th\u00e0nh m\u1eafc b\u1ec7nh x\u01a1 v\u1eefa \u0111\u1ed9ng m\u1ea1ch ho\u1eb7c c\u00f3 nhi\u1ec1u y\u1ebfu t\u1ed1 nguy c\u01a1 m\u1eafc b\u1ec7nh tim m\u1ea1ch.<\/span><\/p>\n<h3><span style=\"font-weight: 400;\">2.2 Li\u1ec1u l\u01b0\u1ee3ng v\u00e0 c\u00e1ch d\u00f9ng<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">Li\u1ec1u khuy\u1ebfn c\u00e1o l\u00e0 0,5 mg u\u1ed1ng m\u1ed7i ng\u00e0y m\u1ed9t l\u1ea7n<\/span><\/p>\n<p><span style=\"font-weight: 400;\">N\u1ebfu qu\u00ean li\u1ec1u, n\u00ean d\u00f9ng li\u1ec1u \u0111\u00e3 qu\u00ean c\u00e0ng s\u1edbm c\u00e0ng t\u1ed1t v\u00e0 sau \u0111\u00f3 b\u1ec7nh nh\u00e2n n\u00ean quay l\u1ea1i l\u1ecbch tr\u00ecnh d\u00f9ng thu\u1ed1c b\u00ecnh th\u01b0\u1eddng. N\u1ebfu m\u1ed9t li\u1ec1u b\u1ecb b\u1ecf qua, b\u1ec7nh nh\u00e2n kh\u00f4ng n\u00ean t\u0103ng g\u1ea5p \u0111\u00f4i li\u1ec1u ti\u1ebfp theo<\/span><\/p>\n<h3><span style=\"font-weight: 400;\">2.3 C\u01a1 ch\u1ebf t\u00e1c d\u1ee5ng\u00a0<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">Th\u00e0nh ph\u1ea7n quan tr\u1ecdng trong Lodoco l\u00e0 Colchicine \u2013 l\u00e0 m\u1ed9t ch\u1ea5t \u1ee9c ch\u1ebf Microtubule, c\u00f3 th\u1ec3 \u1ee9c ch\u1ebf s\u1ef1 ph\u00e1t tri\u1ec3n c\u1ee7a t\u1ebf b\u00e0o v\u00e0 l\u00e0m gi\u1ea3m s\u1ef1 ph\u1ea3n \u1ee9ng vi\u00eam trong c\u01a1 th\u1ec3. S\u1ef1 \u1ee9c ch\u1ebf Microtubule c\u1ee7a Colchicine d\u1eabn \u0111\u1ebfn gi\u1ea3m s\u1ef1 di chuy\u1ec3n c\u1ee7a b\u1ea1ch c\u1ea7u trung t\u00ednh v\u00e0 ng\u0103n ch\u1eb7n s\u1ef1 ph\u00e1t tri\u1ec3n c\u1ee7a vi \u1ed1ng trong t\u1ebf b\u00e0o. \u0110i\u1ec1u n\u00e0y c\u00f3 th\u1ec3 gi\u1ea3i th\u00edch t\u1ea1i sao Colchicine c\u00f3 th\u1ec3 l\u00e0m gi\u1ea3m s\u1ef1 ph\u00e1t tri\u1ec3n c\u1ee7a c\u00e1c tri\u1ec7u ch\u1ee9ng b\u1ec7nh tim m\u1ea1ch, bao g\u1ed3m vi\u00eam m\u00e0ng c\u01a1 tim v\u00e0 c\u01a1n \u0111au th\u1eaft ng\u1ef1c. Ngo\u00e0i ra, Colchicine c\u0169ng c\u00f3 th\u1ec3 can thi\u1ec7p v\u00e0o qu\u00e1 tr\u00ecnh t\u1eadp h\u1ee3p n\u1ed9i b\u00e0o c\u1ee7a ph\u1ee9c h\u1ee3p inflammasome, gi\u00fap ng\u0103n ch\u1eb7n s\u1ef1 k\u00edch ho\u1ea1t c\u1ee7a interleukin-1\u03b2, m\u1ed9t ph\u00e2n t\u1eed g\u00e2y vi\u00eam quan tr\u1ecdng \u0111\u1ed3ng th\u1eddi l\u00e0m gi\u1ea3m \u0111\u1ed9 nh\u1ea1y c\u1ee7a CRP (ch\u1ea5t c\u1ea5u th\u00e0nh c\u1ee7a h\u1ec7 th\u1ed1ng mi\u1ec5n d\u1ecbch v\u00e0 l\u00e0 m\u1ed9t ch\u1ec9 s\u1ed1 cho s\u1ef1 ph\u1ea3n \u1ee9ng vi\u00eam trong c\u01a1 th\u1ec3)<\/span><\/p>\n<h3><span style=\"font-weight: 400;\">2.4 Ch\u1ed1ng ch\u1ec9 \u0111\u1ecbnh\u00a0<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">Thu\u1ed1c ch\u1ed1ng ch\u1ec9 \u0111\u1ecbnh s\u1eed d\u1ee5ng \u0111\u1ed3ng th\u1eddi c\u00e1c ch\u1ea5t \u1ee9c ch\u1ebf CYP3A4 m\u1ea1nh ho\u1eb7c ch\u1ea5t \u1ee9c ch\u1ebf P-glycoprotein v\u00ec \u0111\u1ed9c t\u00ednh Colchicine \u0111e d\u1ecda t\u00ednh m\u1ea1ng v\u00e0 g\u00e2y t\u1eed vong. B\u00ean c\u1ea1nh \u0111\u00f3, thu\u1ed1c c\u0169ng \u0111\u01b0\u1ee3c ch\u1ed1ng ch\u1ec9 \u0111\u1ecbnh s\u1eed d\u1ee5ng \u1edf b\u1ec7nh nh\u00e2n suy th\u1eadn (\u0111\u1ed9 thanh th\u1ea3i Creatinin th\u1ea5p h\u01a1n 15 ml\/ph\u00fat) v\u00e0 suy gan n\u1eb7ng. Cu\u1ed1i c\u00f9ng, thu\u1ed1c kh\u00f4ng \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng \u1edf nh\u1eefng b\u1ec7nh nh\u00e2n m\u1eafc ch\u1ee9ng r\u1ed1i lo\u1ea1n t\u1ea1o m\u00e1u t\u1eeb tr\u01b0\u1edbc v\u00e0 \u1edf nh\u1eefng b\u1ec7nh nh\u00e2n qu\u00e1 m\u1eabn c\u1ea3m v\u1edbi thu\u1ed1c n\u00e0y ho\u1eb7c b\u1ea5t k\u1ef3 th\u00e0nh ph\u1ea7n n\u00e0o c\u1ee7a thu\u1ed1c<\/span><\/p>\n<h3><span style=\"font-weight: 400;\">2.5 T\u00e1c d\u1ee5ng ph\u1ee5\u00a0<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">C\u00e1c ph\u1ea3n \u1ee9ng b\u1ea5t l\u1ee3i sau \u0111\u00e2y \u0111\u00e3 \u0111\u01b0\u1ee3c x\u00e1c \u0111\u1ecbnh v\u1edbi Colchicine<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">C\u00e1c tri\u1ec7u ch\u1ee9ng tr\u00ean th\u1ea7n kinh c\u01a1: nhi\u1ec5m \u0111\u1ed9c, y\u1ebfu, t\u00ea, d\u1ecb c\u1ea3m, ti\u00eau c\u01a1 v\u00e2n, \u0111au<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Tri\u1ec7u ch\u1ee9ng tr\u00ean ti\u00eau h\u00f3a: ti\u00eau ch\u1ea3y\u00a0<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Tr\u00ean th\u1eadn: suy th\u1eadn c\u1ea5p<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Tr\u00ean da: ph\u00e1t ban v\u00e0 r\u1ee5ng t\u00f3c<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Huy\u1ebft h\u1ecdc: gi\u1ea3m ti\u1ec3u c\u1ea7u, gi\u1ea3m b\u1ea1ch c\u1ea7u, gi\u1ea3m to\u00e0n th\u1ec3 huy\u1ebft c\u1ea7u<\/span><\/li>\n<\/ul>\n<h3><span style=\"font-weight: 400;\">2.6 Qu\u00e1 li\u1ec1u\u00a0<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">Ng\u1ed9 \u0111\u1ed9c Colchicine bi\u1ec3u hi\u1ec7n theo ba giai \u0111o\u1ea1n li\u00ean ti\u1ebfp v\u00e0 th\u01b0\u1eddng ch\u1ed3ng ch\u00e9o l\u00ean nhau<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Giai \u0111o\u1ea1n \u0111\u1ea7u ti\u00ean c\u1ee7a ng\u1ed9 \u0111\u1ed9c c\u1ea5p t\u00ednh Colchicine th\u01b0\u1eddng x\u1ea3y ra trong v\u00f2ng 24 gi\u1edd <\/span><span style=\"font-weight: 400;\">sau khi u\u1ed1ng<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Tri\u1ec7u ch\u1ee9ng ti\u00eau h\u00f3a: \u0111au b\u1ee5ng, bu\u1ed3n n\u00f4n, n\u00f4n v\u00e0 ti\u00eau ch\u1ea3y, \u0111\u1ed3ng th\u1eddi m\u1ea5t n\u01b0\u1edbc \u0111\u00e1ng k\u1ec3, d\u1eabn \u0111\u1ebfn gi\u1ea3m th\u1ec3 t\u00edch<\/span><\/li>\n<\/ul>\n<p><span style=\"font-weight: 400;\">Giai \u0111o\u1ea1n th\u1ee9 hai ph\u00e1t tri\u1ec3n t\u1eeb 24 \u0111\u1ebfn 72 gi\u1edd sau khi u\u1ed1ng<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Tri\u1ec7u ch\u1ee9ng \u0111i\u1ec3n h\u00ecnh: suy \u0111a c\u01a1 quan\u00a0<\/span><\/li>\n<\/ul>\n<p><span style=\"font-weight: 400;\">Giai \u0111o\u1ea1n cu\u1ed1i\u00a0<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">T\u1eed vong th\u01b0\u1eddng l\u00e0 k\u1ebft qu\u1ea3 c\u1ee7a suy h\u00f4 h\u1ea5p v\u00e0 tr\u1ee5y tim m\u1ea1ch<\/span><\/li>\n<\/ul>\n<p><span style=\"font-weight: 400;\">\u0110i\u1ec1u tr\u1ecb: Kh\u00f4ng c\u00f3 thu\u1ed1c gi\u1ea3i \u0111\u1ed9c \u0111\u1eb7c hi\u1ec7u n\u00ean vi\u1ec7c lo\u1ea1i b\u1ecf b\u1eb1ng c\u00e1ch r\u1eeda d\u1ea1 d\u00e0y sau \u0111\u00f3 d\u00f9ng <\/span><span style=\"font-weight: 400;\">than ho\u1ea1t t\u00ednh n\u00ean \u0111\u01b0\u1ee3c th\u1ef1c hi\u1ec7n trong v\u00f2ng 1-2 gi\u1edd sau khi u\u1ed1ng<\/span><\/p>\n<h2><b>3. C\u1ea3nh b\u00e1o v\u00e0 th\u1eadn tr\u1ecdng\u00a0<\/b><\/h2>\n<h3><span style=\"font-weight: 400;\">3.1 R\u1ed1i lo\u1ea1n t\u1ea1o m\u00e1u\u00a0<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">Lodoco c\u00f3 th\u1ec3 g\u00e2y suy t\u1ee7y, gi\u1ea3m b\u1ea1ch c\u1ea7u, gi\u1ea3m b\u1ea1ch c\u1ea7u h\u1ea1t, gi\u1ea3m ti\u1ec3u c\u1ea7u, gi\u1ea3m to\u00e0n th\u1ec3 huy\u1ebft <\/span><span style=\"font-weight: 400;\">c\u1ea7u v\u00e0 thi\u1ebfu m\u00e1u b\u1ea5t s\u1ea3n, c\u00f3 th\u1ec3 \u0111e d\u1ecda \u0111\u1ebfn t\u00ednh m\u1ea1ng ho\u1eb7c g\u00e2y t\u1eed vong. Vi\u1ec7c s\u1eed d\u1ee5ng \u0111\u1ed3ng th\u1eddi c\u00e1c lo\u1ea1i thu\u1ed1c l\u00e0m gi\u1ea3m chuy\u1ec3n h\u00f3a Colchicine ho\u1eb7c s\u1ef1 hi\u1ec7n di\u1ec7n c\u1ee7a suy gan ho\u1eb7c th\u1eadn l\u00e0m t\u0103ng nguy c\u01a1 ch\u1ee9ng r\u1ed1i lo\u1ea1n t\u1ea1o m\u00e1u.<\/span><\/p>\n<h3><span style=\"font-weight: 400;\">3.2 \u0110\u1ed9c t\u00ednh th\u1ea7n kinh c\u01a1<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">Lodoco c\u00f3 th\u1ec3 g\u00e2y ng\u1ed9 \u0111\u1ed9c th\u1ea7n kinh c\u01a1 v\u00e0 ti\u00eau c\u01a1 v\u00e2n. Vi\u1ec7c s\u1eed d\u1ee5ng \u0111\u1ed3ng th\u1eddi c\u00e1c thu\u1ed1c l\u00e0m gi\u1ea3m chuy\u1ec3n h\u00f3a Colchicine ho\u1eb7c suy gan ho\u1eb7c suy th\u1eadn l\u00e0m t\u0103ng nguy c\u01a1 ph\u00e1t tri\u1ec3n \u0111\u1ed9c t\u00ednh th\u1ea7n kinh c\u01a1. N\u1ebfu b\u1ec7nh nh\u00e2n xu\u1ea5t hi\u1ec7n c\u00e1c d\u1ea5u hi\u1ec7u nhi\u1ec5m \u0111\u1ed9c th\u1ea7n kinh c\u01a1, h\u00e3y ng\u1eebng s\u1eed d\u1ee5ng thu\u1ed1c \u0111\u1ec3 t\u00ecm hi\u1ec3u c\u00e1c nguy\u00ean nh\u00e2n kh\u00e1c v\u00e0 ph\u01b0\u01a1ng ph\u00e1p \u0111i\u1ec1u tr\u1ecb th\u00edch h\u1ee3p\u00a0<\/span><\/p>\n<h2><b>4. T\u01b0\u01a1ng t\u00e1c thu\u1ed1c\u00a0<\/b><\/h2>\n<p><span style=\"font-weight: 400;\">Colchicine l\u00e0 ch\u1ea5t n\u1ec1n cho ch\u1ea5t v\u1eadn chuy\u1ec3n P-glycoprotein (P-gp). CYP3A4 l\u00e0 enzyme ch\u00ednh tham gia v\u00e0o qu\u00e1 tr\u00ecnh chuy\u1ec3n h\u00f3a Colchicine. N\u1ebfu Lodoco \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng c\u00f9ng v\u1edbi thu\u1ed1c \u1ee9c ch\u1ebf P-gp (h\u1ea7u h\u1ebft l\u00e0 ch\u1ea5t \u1ee9c ch\u1ebf CYP3A4) l\u00e0m t\u0103ng n\u1ed3ng \u0111\u1ed9 Colchicine<\/span><\/p>\n<table>\n<tbody>\n<tr>\n<td colspan=\"2\"><b>Lo\u1ea1i thu\u1ed1c\u00a0<\/b><\/td>\n<td><b>K\u1ebft qu\u1ea3 \/ H\u1eadu qu\u1ea3<\/b><\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">Ch\u1ea5t \u1ee9c ch\u1ebf m\u1ea1nh CYP3A4<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Atazanavir<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Clarithromycin\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Darunavir + Ritonavir\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Indinavir\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Itraconazole<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Ketoconazole<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Lopinavir + Ritonavir\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Nelfinavir\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Saquinavir\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Telithromycin\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Tipranavir + Ritonavir\u00a0<\/span><\/td>\n<td><span style=\"font-weight: 400;\">T\u0103ng \u0111\u00e1ng k\u1ec3 n\u1ed3ng \u0111\u1ed9 colchicine trong<\/span><\/p>\n<p><span style=\"font-weight: 400;\">huy\u1ebft t\u01b0\u01a1ng<\/span><\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">Ch\u1ea5t \u1ee9c ch\u1ebf v\u1eeba ph\u1ea3i CYP3A4<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Amprenavir<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Aprepitant<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Diltiazem<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Erythromycin\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Fluconazole\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Fosamprenavir\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Verapamil<\/span><\/td>\n<td><span style=\"font-weight: 400;\">S\u1ef1 gia t\u0103ng \u0111\u00e1ng k\u1ec3 n\u1ed3ng \u0111\u1ed9 Colchicine trong huy\u1ebft t\u01b0\u01a1ng<\/span><\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">Digitalis Glycosid<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Digoxin\u00a0<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Ti\u00eau c\u01a1 v\u00e2n\u00a0<\/span><\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">Thu\u1ed1c tr\u00e1nh thai\u00a0<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Ethinyl estradiol\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Norethindrone\u00a0<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Ti\u00eau ch\u1ea3y\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Bu\u1ed3n n\u00f4n\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">\u0110au b\u1ee5ng tr\u00ean\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">\u0110\u1ed5 m\u1ed3 h\u00f4i l\u1ea1nh\u00a0<\/span><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>T\u1eeb tr\u01b0\u1edbc \u0111\u1ebfn nay, b\u1ec7nh tim m\u1ea1ch \u0111\u00e3 tr\u1edf th\u00e0nh m\u1ed9t trong nh\u1eefng nguy\u00ean nh\u00e2n ch\u00ednh g\u00e2y t\u1eed vong tr\u00ean to\u00e0n th\u1ebf gi\u1edbi. V\u00e0 m\u1edbi \u0111\u00e2y, m\u1ed9t tin vui \u0111\u00e3 \u0111\u1ebfn v\u1edbi ng\u00e0nh y t\u1ebf khi C\u01a1 quan Qu\u1ea3n l\u00fd Th\u1ef1c ph\u1ea9m v\u00e0 D\u01b0\u1ee3c ph\u1ea9m Hoa K\u1ef3 (FDA) \u0111\u00e3 ph\u00ea duy\u1ec7t Lodoco &#8211; thu\u1ed1c kh\u00e1ng [&hellip;]<\/p>\n","protected":false},"author":54,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[12],"tags":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v20.4 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Lodoco \u2013 Thu\u1ed1c kh\u00e1ng vi\u00eam \u0111\u1ea7u ti\u00ean gi\u1ea3m nguy c\u01a1 tim m\u1ea1ch<\/title>\n<meta name=\"description\" content=\"B\u00e0i vi\u1ebft n\u00e0y gi\u1edbi thi\u1ec7u v\u1ec1 Lodoco - thu\u1ed1c kh\u00e1ng vi\u00eam \u0111\u1ea7u ti\u00ean \u0111\u01b0\u1ee3c FDA ph\u00ea duy\u1ec7t c\u00f3 kh\u1ea3 n\u0103ng gi\u1ea3m nguy c\u01a1 tim m\u1ea1ch cho b\u1ec7nh nh\u00e2n\" \/>\n<meta name=\"robots\" content=\"noindex, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Lodoco \u2013 Thu\u1ed1c kh\u00e1ng vi\u00eam \u0111\u1ea7u ti\u00ean gi\u1ea3m nguy c\u01a1 tim m\u1ea1ch\" \/>\n<meta property=\"og:description\" content=\"B\u00e0i vi\u1ebft n\u00e0y gi\u1edbi thi\u1ec7u v\u1ec1 Lodoco - 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