{"id":33327,"date":"2023-05-13T20:05:58","date_gmt":"2023-05-13T13:05:58","guid":{"rendered":"http:\/\/noithathoaphat.in\/ctv\/?p=33327"},"modified":"2023-05-13T20:05:58","modified_gmt":"2023-05-13T13:05:58","slug":"he-thong-giai-doc-thioredoxin","status":"publish","type":"post","link":"http:\/\/noithathoaphat.in\/ctv\/index.php\/2023\/05\/13\/he-thong-giai-doc-thioredoxin\/","title":{"rendered":"H\u1ec7 th\u1ed1ng gi\u1ea3i \u0111\u1ed9c Thioredoxin"},"content":{"rendered":"

Ung th\u01b0, m\u1ed9t v\u1ea5n \u0111\u1ec1 s\u1ee9c kh\u1ecfe c\u1ed9ng \u0111\u1ed3ng l\u1edbn, th\u1ec3 hi\u1ec7n s\u1ef1 thay \u0111\u1ed5i oxi h\u00f3a kh\u1eed \u0111\u00e1ng k\u1ec3. H\u1ec7 th\u1ed1ng thioredoxin (Trx), bao g\u1ed3m Trx v\u00e0 Trx reductase (TrxR), c\u0169ng nh\u01b0 protein t\u01b0\u01a1ng t\u00e1c Trx (TXNIP) \u0111\u00f3ng vai tr\u00f2 quan tr\u1ecdng trong vi\u1ec7c ki\u1ec3m so\u00e1t s\u1ef1 c\u00e2n b\u1eb1ng oxi h\u00f3a kh\u1eed c\u1ee7a t\u1ebf b\u00e0o trong t\u1ebf b\u00e0o ung th\u01b0.<\/span><\/p>\n

Gi\u1edbi thi\u1ec7u h\u1ec7 th\u1ed1ng Thioredoxin<\/span><\/h2>\n

H\u1ec7 th\u1ed1ng gi\u1ea3i \u0111\u1ed9c Thioredoxin l\u00e0 m\u1ed9t h\u1ec7 th\u1ed1ng quan tr\u1ecdng trong qu\u00e1 tr\u00ecnh gi\u1ea3i \u0111\u1ed9c c\u01a1 th\u1ec3. N\u00f3 bao g\u1ed3m m\u1ed9t s\u1ed1 enzym v\u00e0 protein ch\u1ee9a selenocysteine, m\u1ed9t amino acid \u0111\u1eb7c bi\u1ec7t ch\u1ee9a selenium. H\u1ec7 th\u1ed1ng n\u00e0y c\u0169ng \u0111\u01b0\u1ee3c g\u1ecdi l\u00e0 h\u1ec7 th\u1ed1ng thioredoxin\/peroxiredoxin hay h\u1ec7 th\u1ed1ng gi\u1ea3i \u0111\u1ed9c selenoprotein.<\/span><\/p>\n

H\u1ec7 th\u1ed1ng bao g\u1ed3m hai enzym ch\u00ednh l\u00e0 Thioredoxin (Trx) v\u00e0 Peroxiredoxin (Prx). Trx l\u00e0 m\u1ed9t protein chuy\u1ec3n h\u00f3a disulfide (thiols) v\u00e0 c\u00f3 kh\u1ea3 n\u0103ng gi\u1ea3m c\u00e1c protein v\u00e0 enzym kh\u00e1c b\u1eb1ng c\u00e1ch trao \u0111\u1ed5i disulfide (thiols) gi\u1eefa ch\u00fang. Trx c\u0169ng c\u00f3 kh\u1ea3 n\u0103ng gi\u1ea3m c\u00e1c radical t\u1ef1 do v\u00e0 c\u00e1c ch\u1ea5t oxy h\u00f3a kh\u00e1c. Prx l\u00e0 m\u1ed9t enzym selenoprotein kh\u00e1c, c\u00f3 kh\u1ea3 n\u0103ng gi\u1ea3m c\u00e1c ch\u1ea5t oxy h\u00f3a b\u1eb1ng c\u00e1ch s\u1eed d\u1ee5ng selenocysteine \u0111\u1ec3 gi\u1ea3m c\u00e1c peroxide.<\/span><\/p>\n

H\u1ec7 th\u1ed1ng gi\u1ea3i \u0111\u1ed9c Thioredoxin ch\u1ee7 y\u1ebfu ho\u1ea1t \u0111\u1ed9ng trong c\u00e1c t\u1ebf b\u00e0o, n\u01a1i m\u00e0 c\u00e1c protein v\u00e0 enzym c\u1ea7n \u0111\u01b0\u1ee3c gi\u1ea3m \u0111\u1ec3 duy tr\u00ec ho\u1ea1t \u0111\u1ed9ng. N\u00f3 c\u0169ng c\u00f3 th\u1ec3 gi\u00fap gi\u1ea3m c\u00e1c ch\u1ea5t \u0111\u1ed9c h\u1ea1i nh\u01b0 hydroperoxide v\u00e0 c\u00e1c ch\u1ea5t oxy h\u00f3a kh\u00e1c. H\u1ec7 th\u1ed1ng n\u00e0y c\u0169ng \u0111\u01b0\u1ee3c li\u00ean k\u1ebft v\u1edbi qu\u00e1 tr\u00ecnh gi\u1ea3m stress oxy h\u00f3a v\u00e0 gi\u1ea3m vi\u00eam.<\/span><\/p>\n

Trong qu\u00e1 tr\u00ecnh gi\u1ea3i \u0111\u1ed9c, h\u1ec7 th\u1ed1ng gi\u1ea3i \u0111\u1ed9c c\u00f3 th\u1ec3 b\u1ecb \u1ea3nh h\u01b0\u1edfng b\u1edfi m\u1ed9t s\u1ed1 ch\u1ea5t \u0111\u1ed9c h\u1ea1i, ch\u1eb3ng h\u1ea1n nh\u01b0 thu\u1ed1c l\u00e1, c\u00e1c ch\u1ea5t \u0111\u1ed9c h\u1ea1i trong m\u00f4i tr\u01b0\u1eddng, ho\u1eb7c c\u00e1c ch\u1ea5t \u0111\u1ed9c h\u1ea1i \u0111\u01b0\u1ee3c s\u1ea3n xu\u1ea5t b\u1edfi c\u00e1c vi khu\u1ea9n ho\u1eb7c virus. Khi h\u1ec7 th\u1ed1ng n\u00e0y b\u1ecb \u1ea3nh h\u01b0\u1edfng, n\u00f3 c\u00f3 th\u1ec3 d\u1eabn \u0111\u1ebfn t\u1ed5n th\u01b0\u01a1ng t\u1ebf b\u00e0o v\u00e0 c\u00e1c t\u00e1c d\u1ee5ng ph\u1ee5 kh\u00e1c.<\/span><\/p>\n

\"he
H\u1ec7 th\u1ed1ng gi\u1ea3i \u0111\u1ed9c Thioredoxin<\/figcaption><\/figure>\n

Thioredoxin trong ung th\u01b0<\/span><\/h2>\n

Thioredoxin \u0111\u01b0\u1ee3c bi\u1ebft \u0111\u1ebfn l\u00e0 m\u1ed9t ch\u1ea5t ch\u1ed1ng oxy h\u00f3a quan tr\u1ecdng trong t\u1ebf b\u00e0o, v\u00e0 n\u00f3 c\u00f3 th\u1ec3 \u0111\u00f3ng vai tr\u00f2 quan tr\u1ecdng trong s\u1ef1 ph\u00e1t tri\u1ec3n v\u00e0 di\u1ec5n ti\u1ebfn c\u1ee7a ung th\u01b0. Nhi\u1ec1u nghi\u00ean c\u1ee9u \u0111\u00e3 ch\u1ec9 ra r\u1eb1ng ho\u1ea1t \u0111\u1ed9ng c\u1ee7a h\u1ec7 th\u1ed1ng gi\u1ea3i \u0111\u1ed9c Thioredoxin c\u00f3 li\u00ean quan ch\u1eb7t ch\u1ebd \u0111\u1ebfn s\u1ef1 ph\u00e1t tri\u1ec3n c\u1ee7a ung th\u01b0.<\/span><\/p>\n

Trong c\u00e1c t\u1ebf b\u00e0o ung th\u01b0, ho\u1ea1t \u0111\u1ed9ng c\u1ee7a h\u1ec7 th\u1ed1ng gi\u1ea3i \u0111\u1ed9c Thioredoxin \u0111\u01b0\u1ee3c t\u0103ng c\u01b0\u1eddng, gi\u00fap t\u1ebf b\u00e0o ung th\u01b0 ch\u1ed1ng l\u1ea1i s\u1ef1 t\u1ed5n th\u01b0\u01a1ng do c\u00e1c t\u00e1c nh\u00e2n g\u00e2y oxy h\u00f3a. \u0110i\u1ec1u n\u00e0y c\u00f3 th\u1ec3 l\u00e0m t\u0103ng kh\u1ea3 n\u0103ng s\u1ed1ng s\u00f3t c\u1ee7a t\u1ebf b\u00e0o ung th\u01b0 v\u00e0 gi\u00fap ch\u00fang ph\u00e1t tri\u1ec3n nhanh ch\u00f3ng.<\/span><\/p>\n

Ngo\u00e0i ra, m\u1ed9t s\u1ed1 nghi\u00ean c\u1ee9u \u0111\u00e3 ch\u1ec9 ra r\u1eb1ng vi\u1ec7c \u1ee9c ch\u1ebf ho\u1ea1t \u0111\u1ed9ng c\u1ee7a h\u1ec7 th\u1ed1ng gi\u1ea3i \u0111\u1ed9c Thioredoxin c\u00f3 th\u1ec3 l\u00e0 m\u1ed9t c\u00e1ch ti\u1ebfp c\u1eadn hi\u1ec7u qu\u1ea3 trong \u0111i\u1ec1u tr\u1ecb ung th\u01b0. M\u1ed9t s\u1ed1 ch\u1ea5t \u1ee9c ch\u1ebf ho\u1ea1t \u0111\u1ed9ng c\u1ee7a h\u1ec7 th\u1ed1ng n\u00e0y \u0111\u00e3 \u0111\u01b0\u1ee3c ph\u00e1t tri\u1ec3n v\u00e0 \u0111ang \u0111\u01b0\u1ee3c nghi\u00ean c\u1ee9u nh\u01b0 l\u00e0 c\u00e1c ti\u1ec1m n\u0103ng ch\u1ea5t \u0111i\u1ec1u tr\u1ecb ung th\u01b0.<\/span><\/p>\n

V\u00ed d\u1ee5, m\u1ed9t s\u1ed1 ch\u1ea5t \u1ee9c ch\u1ebf h\u1ec7 th\u1ed1ng gi\u1ea3i \u0111\u1ed9c Thioredoxin nh\u01b0 PX-12 v\u00e0 TRx008 \u0111\u00e3 \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng trong c\u00e1c nghi\u00ean c\u1ee9u v\u00e0 th\u1eed nghi\u1ec7m \u0111i\u1ec1u tr\u1ecb ung th\u01b0 t\u1ea1i Trung Qu\u1ed1c v\u00e0 H\u00e0n Qu\u1ed1c. Nghi\u00ean c\u1ee9u ch\u1ec9 ra r\u1eb1ng vi\u1ec7c s\u1eed d\u1ee5ng c\u00e1c ch\u1ea5t \u1ee9c ch\u1ebf h\u1ec7 th\u1ed1ng gi\u1ea3i \u0111\u1ed9c Thioredoxin c\u00f3 th\u1ec3 gi\u00fap t\u0103ng hi\u1ec7u qu\u1ea3 c\u1ee7a c\u00e1c ph\u01b0\u01a1ng ph\u00e1p \u0111i\u1ec1u tr\u1ecb kh\u00e1c, ch\u1eb3ng h\u1ea1n nh\u01b0 ph\u01b0\u01a1ng ph\u00e1p h\u00f3a tr\u1ecb.<\/span><\/p>\n

M\u1ed9t s\u1ed1 lo\u1ea1i ung th\u01b0 m\u00e0 h\u1ec7 th\u1ed1ng gi\u1ea3i \u0111\u1ed9c Thioredoxin c\u00f3 th\u1ec3 \u0111\u01b0\u1ee3c \u00e1p d\u1ee5ng trong \u0111i\u1ec1u tr\u1ecb bao g\u1ed3m:<\/span><\/p>\n

    \n
  • Ung th\u01b0 ph\u1ed5i<\/span><\/li>\n
  • Ung th\u01b0 gan<\/span><\/li>\n
  • Ung th\u01b0 v\u00fa<\/span><\/li>\n
  • Ung th\u01b0 \u0111\u1ea1i tr\u1ef1c tr\u00e0ng<\/span><\/li>\n<\/ul>\n

    T\u00e1c d\u1ee5ng ph\u1ee5<\/span><\/h2>\n

    T\u00e1c d\u1ee5ng ph\u1ee5 c\u00f3 th\u1ec3 g\u1eb7p ph\u1ea3i khi s\u1eed d\u1ee5ng c\u00e1c ch\u1ea5t n\u00e0y bao g\u1ed3m:<\/span><\/p>\n

      \n
    • Gi\u1ea3m mi\u1ec5n d\u1ecbch: C\u00e1c ch\u1ea5t \u1ee9c ch\u1ebf h\u1ec7 th\u1ed1ng gi\u1ea3i \u0111\u1ed9c Thioredoxin c\u00f3 th\u1ec3 \u1ea3nh h\u01b0\u1edfng \u0111\u1ebfn h\u1ec7 th\u1ed1ng mi\u1ec5n d\u1ecbch, g\u00e2y ra gi\u1ea3m mi\u1ec5n d\u1ecbch v\u00e0 t\u0103ng nguy c\u01a1 nhi\u1ec5m tr\u00f9ng.<\/span><\/li>\n
    • T\u00e1c \u0111\u1ed9ng \u0111\u1ebfn s\u1ef1 ph\u00e1t tri\u1ec3n c\u1ee7a c\u00e1c t\u1ebf b\u00e0o kh\u00e1c trong c\u01a1 th\u1ec3: C\u00e1c ch\u1ea5t \u1ee9c ch\u1ebf h\u1ec7 th\u1ed1ng gi\u1ea3i \u0111\u1ed9c Thioredoxin c\u00f3 th\u1ec3 t\u00e1c \u0111\u1ed9ng \u0111\u1ebfn s\u1ef1 ph\u00e1t tri\u1ec3n c\u1ee7a c\u00e1c t\u1ebf b\u00e0o kh\u00e1c trong c\u01a1 th\u1ec3, g\u00e2y ra c\u00e1c t\u00e1c d\u1ee5ng ph\u1ee5 kh\u00f4ng mong mu\u1ed1n.<\/span><\/li>\n
    • T\u00e1c d\u1ee5ng \u0111\u1ed9c t\u00ednh: M\u1ed9t s\u1ed1 ch\u1ea5t \u1ee9c ch\u1ebf h\u1ec7 th\u1ed1ng gi\u1ea3i \u0111\u1ed9c Thioredoxin c\u00f3 th\u1ec3 g\u00e2y ra t\u00e1c d\u1ee5ng \u0111\u1ed9c t\u00ednh, g\u00e2y ra c\u00e1c v\u1ea5n \u0111\u1ec1 v\u1ec1 gan, th\u1eadn, tim m\u1ea1ch v\u00e0 th\u1ea7n kinh.<\/span><\/li>\n
    • T\u00e1c \u0111\u1ed9ng \u0111\u1ebfn s\u1ef1 ph\u00e1t tri\u1ec3n c\u1ee7a t\u1ebf b\u00e0o: C\u00e1c ch\u1ea5t \u1ee9c ch\u1ebf h\u1ec7 th\u1ed1ng gi\u1ea3i \u0111\u1ed9c Thioredoxin c\u00f3 th\u1ec3 \u1ea3nh h\u01b0\u1edfng \u0111\u1ebfn s\u1ef1 ph\u00e1t tri\u1ec3n c\u1ee7a t\u1ebf b\u00e0o, g\u00e2y ra c\u00e1c t\u00e1c d\u1ee5ng ph\u1ee5 nh\u01b0 s\u1ea9y thai ho\u1eb7c \u0111\u1ed9c h\u1ea1i cho thai nhi.<\/span><\/li>\n<\/ul>\n

      Ngo\u00e0i ra, c\u00e1c t\u00e1c d\u1ee5ng ph\u1ee5 kh\u00e1c c\u0169ng c\u00f3 th\u1ec3 x\u1ea3y ra t\u00f9y thu\u1ed9c v\u00e0o t\u1eebng lo\u1ea1i ch\u1ea5t \u1ee9c ch\u1ebf h\u1ec7 th\u1ed1ng gi\u1ea3i \u0111\u1ed9c Thioredoxin c\u1ee5 th\u1ec3 v\u00e0 li\u1ec1u l\u01b0\u1ee3ng s\u1eed d\u1ee5ng.<\/span><\/p>\n

      K\u1ebft lu\u1eadn<\/span><\/h2>\n

      Hi\u1ec7n nay, h\u1ec7 th\u1ed1ng gi\u1ea3i \u0111\u1ed9c Thioredoxin v\u1eabn \u0111ang trong qu\u00e1 tr\u00ecnh nghi\u00ean c\u1ee9u v\u00e0 ch\u01b0a \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng r\u1ed9ng r\u00e3i trong \u0111i\u1ec1u tr\u1ecb ung th\u01b0 t\u1ea1i c\u00e1c n\u01b0\u1edbc ph\u00e1t tri\u1ec3n. Tuy nhi\u00ean, c\u00e1c nghi\u00ean c\u1ee9u tr\u00ean t\u1ebf b\u00e0o ung th\u01b0 v\u00e0 tr\u00ean \u0111\u1ed9ng v\u1eadt \u0111\u00e3 cho th\u1ea5y ti\u1ec1m n\u0103ng c\u1ee7a h\u1ec7 th\u1ed1ng gi\u1ea3i \u0111\u1ed9c Thioredoxin trong \u0111i\u1ec1u tr\u1ecb ung th\u01b0.<\/span><\/p>\n

      \u0110i\u1ec1u quan tr\u1ecdng c\u1ea7n l\u01b0u \u00fd l\u00e0, vi\u1ec7c \u0111i\u1ec1u tr\u1ecb ung th\u01b0 l\u00e0 m\u1ed9t qu\u00e1 tr\u00ecnh ph\u1ee9c t\u1ea1p v\u00e0 \u0111\u00f2i h\u1ecfi s\u1ef1 k\u1ebft h\u1ee3p c\u1ee7a nhi\u1ec1u ph\u01b0\u01a1ng ph\u00e1p \u0111i\u1ec1u tr\u1ecb kh\u00e1c nhau. H\u1ec7 th\u1ed1ng gi\u1ea3i \u0111\u1ed9c Thioredoxin c\u00f3 th\u1ec3 l\u00e0 m\u1ed9t ph\u01b0\u01a1ng ph\u00e1p ti\u1ec1m n\u0103ng trong \u0111i\u1ec1u tr\u1ecb ung th\u01b0, nh\u01b0ng c\u1ea7n \u0111\u01b0\u1ee3c \u0111\u00e1nh gi\u00e1 k\u1ef9 l\u01b0\u1ee1ng v\u00e0 ph\u1ed1i h\u1ee3p v\u1edbi c\u00e1c ph\u01b0\u01a1ng ph\u00e1p \u0111i\u1ec1u tr\u1ecb kh\u00e1c \u0111\u1ec3 \u0111\u1ea1t hi\u1ec7u qu\u1ea3 t\u1ed1t nh\u1ea5t trong \u0111i\u1ec1u tr\u1ecb ung th\u01b0.<\/span><\/p>\n

      T\u00f3m l\u1ea1i, hi\u1ec7n nay, h\u1ec7 th\u1ed1ng gi\u1ea3i \u0111\u1ed9c Thioredoxin v\u1eabn \u0111ang trong giai \u0111o\u1ea1n nghi\u00ean c\u1ee9u v\u00e0 ch\u01b0a \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng r\u1ed9ng r\u00e3i trong \u0111i\u1ec1u tr\u1ecb ung th\u01b0 t\u1ea1i c\u00e1c n\u01b0\u1edbc ph\u00e1t tri\u1ec3n. Vi\u1ec7c s\u1eed d\u1ee5ng c\u00e1c ch\u1ea5t \u1ee9c ch\u1ebf h\u1ec7 th\u1ed1ng gi\u1ea3i \u0111\u1ed9c Thioredoxin trong \u0111i\u1ec1u tr\u1ecb ung th\u01b0 c\u1ea7n \u0111\u01b0\u1ee3c th\u1ef1c hi\u1ec7n d\u01b0\u1edbi s\u1ef1 gi\u00e1m s\u00e1t c\u1ee7a c\u00e1c chuy\u00ean gia y t\u1ebf v\u00e0 c\u1ea7n \u0111\u01b0\u1ee3c \u0111\u00e1nh gi\u00e1 k\u1ef9 l\u01b0\u1ee1ng v\u1ec1 m\u1eb7t an to\u00e0n v\u00e0 hi\u1ec7u qu\u1ea3.<\/span><\/p>\n

      Ngu\u1ed3n: Springer Link, Pubmed<\/span><\/p>\n","protected":false},"excerpt":{"rendered":"

      Ung th\u01b0, m\u1ed9t v\u1ea5n \u0111\u1ec1 s\u1ee9c kh\u1ecfe c\u1ed9ng \u0111\u1ed3ng l\u1edbn, th\u1ec3 hi\u1ec7n s\u1ef1 thay \u0111\u1ed5i oxi h\u00f3a kh\u1eed \u0111\u00e1ng k\u1ec3. H\u1ec7 th\u1ed1ng thioredoxin (Trx), bao g\u1ed3m Trx v\u00e0 Trx reductase (TrxR), c\u0169ng nh\u01b0 protein t\u01b0\u01a1ng t\u00e1c Trx (TXNIP) \u0111\u00f3ng vai tr\u00f2 quan tr\u1ecdng trong vi\u1ec7c ki\u1ec3m so\u00e1t s\u1ef1 c\u00e2n b\u1eb1ng oxi h\u00f3a kh\u1eed c\u1ee7a t\u1ebf […]<\/p>\n","protected":false},"author":57,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[6,33],"tags":[],"yoast_head":"\nH\u1ec7 th\u1ed1ng gi\u1ea3i \u0111\u1ed9c Thioredoxin - Vinmec<\/title>\n<meta name=\"description\" content=\"H\u1ec7 th\u1ed1ng thioredoxin (Trx) g\u1ed3m Trx v\u00e0 Trx reductase (TrxR), protein t\u01b0\u01a1ng t\u00e1c Trx (TXNIP) ki\u1ec3m so\u00e1t c\u00e2n b\u1eb1ng oxi h\u00f3a kh\u1eed c\u1ee7a t\u1ebf b\u00e0o ung th\u01b0.\" \/>\n<meta name=\"robots\" content=\"noindex, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"H\u1ec7 th\u1ed1ng gi\u1ea3i \u0111\u1ed9c Thioredoxin - 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