{"id":33028,"date":"2023-05-13T11:42:35","date_gmt":"2023-05-13T04:42:35","guid":{"rendered":"http:\/\/noithathoaphat.in\/ctv\/?p=33028"},"modified":"2023-05-13T11:42:35","modified_gmt":"2023-05-13T04:42:35","slug":"altuviiio-buoc-tien-moi-trong-dieu-tri-mau-kho-dong-loai-a","status":"publish","type":"post","link":"http:\/\/noithathoaphat.in\/ctv\/index.php\/2023\/05\/13\/altuviiio-buoc-tien-moi-trong-dieu-tri-mau-kho-dong-loai-a\/","title":{"rendered":"Altuviiio: B\u01b0\u1edbc ti\u1ebfn m\u1edbi trong \u0111i\u1ec1u tr\u1ecb m\u00e1u kh\u00f3 \u0111\u00f4ng lo\u1ea1i A"},"content":{"rendered":"<p><b>B\u1ec7nh m\u00e1u kh\u00f3 \u0111\u00f4ng lo\u1ea1i A l\u00e0 m\u1ed9t b\u1ec7nh di truy\u1ec1n g\u00e2y ra s\u1ef1 thi\u1ebfu h\u1ee5t y\u1ebfu t\u1ed1 VIII trong h\u1ec7 th\u1ed1ng \u0111\u00f4ng m\u00e1u. Trong nhi\u1ec1u n\u0103m qua, \u0111i\u1ec1u tr\u1ecb b\u1ec7nh n\u00e0y ch\u1ee7 y\u1ebfu d\u1ef1a v\u00e0o vi\u1ec7c s\u1eed d\u1ee5ng y\u1ebfu t\u1ed1 VIII thay th\u1ebf. Tuy nhi\u00ean, ti\u1ebfn b\u1ed9 m\u1edbi \u0111\u00e3 \u0111\u1ea1t \u0111\u01b0\u1ee3c v\u1edbi s\u1ef1 ra \u0111\u1eddi c\u1ee7a Altuviiio &#8211; m\u1ed9t lo\u1ea1i dung h\u1ee3p protein c\u00f3 kh\u1ea3 n\u0103ng \u0111\u1ed9c l\u1eadp v\u1edbi y\u1ebfu t\u1ed1 von Willebrand v\u00e0 th\u1eddi gian b\u00e1n h\u1ee7y k\u00e9o d\u00e0i hi\u1ec7u qu\u1ea3 trong \u0111i\u1ec1u tr\u1ecb b\u1ec7nh m\u00e1u kh\u00f3 \u0111\u00f4ng. B\u00e0i vi\u1ebft n\u00e0y s\u1ebd t\u00ecm hi\u1ec3u v\u1ec1 Altuviiio v\u00e0 nh\u1eefng ti\u1ec1m n\u0103ng c\u1ee7a n\u00f3 trong vi\u1ec7c c\u1ea3i thi\u1ec7n ch\u1ea5t l\u01b0\u1ee3ng cu\u1ed9c s\u1ed1ng c\u1ee7a b\u1ec7nh nh\u00e2n<\/b><\/p>\n<h2><b>1.Gi\u1edbi thi\u1ec7u s\u01a1 l\u01b0\u1ee3c v\u1ec1 b\u1ec7nh m\u00e1u kh\u00f3 \u0111\u00f4ng (Hemophilia)<\/b><\/h2>\n<h3><span style=\"font-weight: 400;\">1.1 B\u1ec7nh m\u00e1u kh\u00f3 \u0111\u00f4ng (Hemophilia)<\/span><\/h3>\n<p><span style=\"font-weight: 400;\"><a href=\"https:\/\/www.vinmec.com\/vi\/benh\/mau-kho-dong-3219\/\">B\u1ec7nh m\u00e1u kh\u00f3 \u0111\u00f4ng<\/a> l\u00e0 m\u1ed9t nh\u00f3m b\u1ec7nh di truy\u1ec1n l\u00e0m thay \u0111\u1ed5i qu\u00e1 tr\u00ecnh \u0111\u00f4ng m\u00e1u b\u00ecnh th\u01b0\u1eddng c\u1ee7a c\u01a1 th\u1ec3 \u0111\u01b0\u1ee3c bi\u1ec3u hi\u1ec7n b\u1eb1ng ch\u1ea3y m\u00e1u k\u00e9o d\u00e0i v\u00e0 qu\u00e1 nhi\u1ec1u m\u1ed9t c\u00e1ch t\u1ef1 nhi\u00ean ho\u1eb7c sau ch\u1ea5n th\u01b0\u01a1ng nh\u1eb9.\u00a0<\/span><\/p>\n<figure id=\"attachment_33620\" aria-describedby=\"caption-attachment-33620\" style=\"width: 300px\" class=\"wp-caption aligncenter\"><img decoding=\"async\" loading=\"lazy\" class=\"size-medium wp-image-33620\" src=\"http:\/\/noithathoaphat.in\/ctv\/wp-content\/uploads\/2023\/05\/Benh-mau-kho-dong-loai-A-Hemophilia-A-300x199.png\" alt=\"B\u1ec7nh m\u00e1u kh\u00f3 \u0111\u00f4ng (Hemophilia)\" width=\"300\" height=\"199\" srcset=\"http:\/\/noithathoaphat.in\/ctv\/wp-content\/uploads\/2023\/05\/Benh-mau-kho-dong-loai-A-Hemophilia-A-300x199.png 300w, http:\/\/noithathoaphat.in\/ctv\/wp-content\/uploads\/2023\/05\/Benh-mau-kho-dong-loai-A-Hemophilia-A.png 411w\" sizes=\"(max-width: 300px) 100vw, 300px\" \/><figcaption id=\"caption-attachment-33620\" class=\"wp-caption-text\">B\u1ec7nh m\u00e1u kh\u00f3 \u0111\u00f4ng (Hemophilia)<\/figcaption><\/figure>\n<p><span style=\"font-weight: 400;\">B\u1ec7nh m\u00e1u kh\u00f3 \u0111\u00f4ng \u0111\u01b0\u1ee3c ph\u00e2n th\u00e0nh 3 d\u1ea1ng ch\u00ednh: Hemophilia A, B v\u00e0 C<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Hemophilia A: l\u00e0 lo\u1ea1i ph\u1ed5 bi\u1ebfn nh\u1ea5t chi\u1ebfm kho\u1ea3ng 80% ca b\u1ec7nh, \u0111\u01b0\u1ee3c g\u00e2y ra b\u1edfi s\u1ef1 thi\u1ebfu h\u1ee5t ho\u1eb7c kh\u00f4ng c\u00f3 y\u1ebfu t\u1ed1 \u0111\u00f4ng m\u00e1u VIII<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Hemophilia B: l\u00e0 lo\u1ea1i hi\u1ebfm h\u01a1n ch\u1ec9 chi\u1ebfm kho\u1ea3ng 20%\u00a0 v\u00e0 \u0111\u01b0\u1ee3c g\u00e2y ra b\u1edfi s\u1ef1 thi\u1ebfu h\u1ee5t ho\u1eb7c kh\u00f4ng c\u00f3 y\u1ebfu t\u1ed1 \u0111\u00f4ng m\u00e1u IX<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Hemophilia C: l\u00e0 d\u1ea1ng hi\u1ebfm h\u01a1n v\u00e0 do thi\u1ebfu h\u1ee5t ho\u1eb7c kh\u00f4ng c\u00f3 y\u1ebfu t\u1ed1 XI \u0111\u00f4ng m\u00e1u trong m\u00e1u, th\u01b0\u1eddng g\u1eb7p \u1edf ng\u01b0\u1eddi Do Th\u00e1i Ashkenazi v\u00e0 di truy\u1ec1n theo ki\u1ec3u ph\u1ea3n x\u1ea1 li\u00ean quan \u0111\u1ebfn Chromosome X<\/span><\/li>\n<\/ul>\n<p><span style=\"font-weight: 400;\">Nguy\u00ean nh\u00e2n c\u1ee7a b\u1ec7nh n\u00e0y l\u00e0 do thi\u1ebfu h\u1ee5t m\u1ed9t trong hai protein quan tr\u1ecdng trong qu\u00e1 tr\u00ecnh \u0111\u00f4ng m\u00e1u l\u00e0 Factor VIII v\u00e0 Factor IX, \u0111\u00e2y l\u00e0 hai protein \u0111\u00f3ng vai tr\u00f2 quan tr\u1ecdng trong qu\u00e1 tr\u00ecnh \u0111\u00f4ng m\u00e1u. Khi b\u1ecb ch\u1ea5n th\u01b0\u01a1ng ho\u1eb7c x\u1ea3y ra v\u1ebft c\u1eaft, m\u1ed9t chu\u1ed7i ph\u1ea3n \u1ee9ng h\u00f3a h\u1ecdc s\u1ebd x\u1ea3y ra \u0111\u1ec3 k\u00edch ho\u1ea1t c\u00e1c y\u1ebfu t\u1ed1 \u0111\u00f4ng m\u00e1u<\/span><\/p>\n<h3><span style=\"font-weight: 400;\">1.2 B\u1ec7nh m\u00e1u kh\u00f3 \u0111\u00f4ng lo\u1ea1i A (Hemophilia A)<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">B\u1ec7nh m\u00e1u kh\u00f3 \u0111\u00f4ng lo\u1ea1i A l\u00e0 m\u1ed9t lo\u1ea1i b\u1ec7nh di truy\u1ec1n khi\u1ebfn cho ng\u01b0\u1eddi b\u1ec7nh kh\u00f3 c\u00f3 th\u1ec3 \u0111\u00f4ng m\u00e1u b\u00ecnh th\u01b0\u1eddng sau khi b\u1ecb ch\u1ea5n th\u01b0\u01a1ng ho\u1eb7c c\u1eaft. \u0110\u00e2y l\u00e0 lo\u1ea1i b\u1ec7nh m\u00e1u kh\u00f3 \u0111\u00f4ng ph\u1ed5 bi\u1ebfn nh\u1ea5t, chi\u1ebfm kho\u1ea3ng 80% tr\u01b0\u1eddng h\u1ee3p b\u1ec7nh m\u00e1u kh\u00f3 \u0111\u00f4ng.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">B\u1ec7nh m\u00e1u kh\u00f3 \u0111\u00f4ng lo\u1ea1i A l\u00e0 r\u1ed1i lo\u1ea1n c\u1ea7m m\u00e1u di truy\u1ec1n ph\u1ed5 bi\u1ebfn nh\u1ea5t, x\u1ea3y ra \u1edf m\u1ed9t trong s\u1ed1 5000 nam gi\u1edbi v\u00e0 chi\u1ebfm 80% c\u00e1c tr\u01b0\u1eddng h\u1ee3p m\u1eafc b\u1ec7nh m\u00e1u kh\u00f3 \u0111\u00f4ng. Hemophilia A x\u1ea3y ra \u1edf h\u01a1n 400000 nam gi\u1edbi tr\u00ean to\u00e0n th\u1ebf gi\u1edbi nh\u01b0ng \u1edf c\u00e1c n\u01b0\u1edbc \u0111ang ph\u00e1t tri\u1ec3n nhi\u1ec1u ng\u01b0\u1eddi v\u1eabn ch\u01b0a \u0111\u01b0\u1ee3c ch\u1ea9n \u0111o\u00e1n m\u1eafc b\u1ec7nh<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Khi l\u1edbp n\u1ed9i m\u1ea1c m\u1ea1ch m\u00e1u b\u1ecb t\u1ed5n th\u01b0\u01a1ng, m\u1ed9t lo\u1ea1t c\u00e1c ph\u1ea3n \u1ee9ng sinh h\u00f3a x\u1ea3y ra \u0111\u1ec3 ng\u0103n ch\u1eb7n ch\u1ea3y m\u00e1u ti\u1ebfp theo, gi\u00fap kh\u00f4i ph\u1ee5c t\u00ednh to\u00e0n v\u1eb9n c\u1ee7a m\u1ea1ch m\u00e1u. Qu\u00e1 tr\u00ecnh n\u00e0y b\u1eaft \u0111\u1ea7u b\u1eb1ng vi\u1ec7c ho\u1ea1t h\u00f3a c\u00e1c ti\u1ec3u c\u1ea7u t\u1ea1i v\u1ecb tr\u00ed b\u1ecb t\u1ed5n th\u01b0\u01a1ng. C\u00e1c ti\u1ec3u c\u1ea7u s\u1ebd s\u1ea3n xu\u1ea5t c\u00e1c y\u1ebfu t\u1ed1 \u0111\u00f4ng m\u00e1u (y\u1ebfu t\u1ed1 VIII) v\u00e0 h\u00ecnh th\u00e0nh Fibrin \u0111\u1ec3 t\u1ea1o th\u00e0nh m\u1ed9t l\u01b0\u1edbi m\u1ea1ng d\u00e0y \u0111\u1eb7c (n\u00fat ti\u1ec3u c\u1ea7u \u2013 Fibrin) \u0111\u1ec3 ng\u0103n ch\u1eb7n d\u00f2ng m\u00e1u ch\u1ea3y ti\u1ebfp t\u1ee5c. Y\u1ebfu t\u1ed1 VIII t\u0103ng c\u01b0\u1eddng cho qu\u00e1 tr\u00ecnh t\u1ea1o Thrombin v\u00e0 th\u00fac \u0111\u1ea9y qu\u00e1 tr\u00ecnh h\u00ecnh th\u00e0nh Fibrin. \u0110\u1ed1i v\u1edbi b\u1ec7nh m\u00e1u kh\u00f3 \u0111\u00f4ng lo\u1ea1i A, thi\u1ebfu h\u1ee5t y\u1ebfu t\u1ed1 VIII kh\u00f4ng t\u1ea1o ra \u0111\u1ee7 Fibrin, d\u1eabn \u0111\u1ebfn qu\u00e1 tr\u00ecnh c\u1ea7m m\u00e1u th\u1ee9 ph\u00e1t kh\u00f4ng h\u00ecnh th\u00e0nh.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">C\u00e1c tri\u1ec7u ch\u1ee9ng c\u1ee7a b\u1ec7nh m\u00e1u kh\u00f3 \u0111\u00f4ng lo\u1ea1i A c\u00f3 th\u1ec3 bi\u1ec3u hi\u1ec7n kh\u00e1c nhau t\u00f9y thu\u1ed9c v\u00e0o m\u1ee9c \u0111\u1ed9 nghi\u00eam tr\u1ecdng c\u1ee7a b\u1ec7nh. Tuy nhi\u00ean, c\u00e1c tri\u1ec7u ch\u1ee9ng ch\u00ednh bao g\u1ed3m:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Ch\u1ea3y m\u00e1u n\u1ed9i s\u1ecd t\u1ef1 ph\u00e1t \u1edf tr\u1ebb s\u01a1 sinh: \u0111\u00e2y l\u00e0 bi\u1ec3u hi\u1ec7n \u0111e d\u1ecda t\u00ednh m\u1ea1ng di\u1ec5n ra trong th\u1eddi gian ng\u1eafn v\u00e0 c\u00f3 kh\u1ea3 n\u0103ng g\u00e2y khuy\u1ebft t\u1eadt th\u1ea7n kinh m\u1ea1n t\u00ednh v\u00e0 di ch\u1ee9ng th\u1ea7n kinh l\u00e2u d\u00e0i<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Ch\u1ea3y m\u00e1u qu\u00e1 nhi\u1ec1u sau ph\u1eabu thu\u1eadt ho\u1eb7c sau khi c\u1eaft bao quy \u0111\u1ea7u: \u0111\u00e2y l\u00e0 bi\u1ec3u hi\u1ec7n c\u1ee7a qu\u00e1 tr\u00ecnh kh\u00f4ng \u0111\u00f4ng m\u00e1u trong qu\u00e1 tr\u00ecnh ph\u1eabu thu\u1eadt ho\u1eb7c khi c\u1eaft bao quy \u0111\u1ea7u\u00a0<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Xu\u1ea5t huy\u1ebft kh\u1edbp g\u00e2y \u0111au \u0111\u1edbn do ch\u1ea5n th\u01b0\u01a1ng: \u0111\u00e2y l\u00e0 tri\u1ec7u ch\u1ee9ng ph\u1ed5 bi\u1ebfn \u1edf thanh thi\u1ebfu ni\u00ean v\u00e0 ng\u01b0\u1eddi l\u1edbn, n\u1ebfu t\u00e1i ph\u00e1t g\u00e2y d\u1ec5 g\u00e2y x\u00f3i m\u00f2n s\u1ee5n kh\u1edbp v\u00e0 \u0111au kh\u1edbp Charcot (bi\u1ebfn ch\u1ee9ng c\u1ee7a b\u1ec7nh \u01b0a kh\u1edbp ch\u1ea3y m\u00e1u)<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">V\u1ebft b\u1ea7m t\u00edm xu\u1ea5t hi\u1ec7n do vi\u1ec7c xu\u1ea5t huy\u1ebft c\u01a1 da b\u1ea5t th\u01b0\u1eddng sau khi c\u00e1c m\u00f4 v\u00e0 kh\u1edbp b\u1ecb t\u1ed5n th\u01b0\u01a1ng do c\u00e1c ho\u1ea1t \u0111\u1ed9ng nh\u01b0 b\u00f2 ho\u1eb7c \u0111i<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">V\u1ebft gi\u1eadp m\u00f4 m\u1ec1m v\u00e0 xu\u1ea5t huy\u1ebft<\/span><\/li>\n<\/ul>\n<p><span style=\"font-weight: 400;\">C\u00e1c li\u1ec7u ph\u00e1p b\u1ed5 sung d\u01b0\u1ee3c ph\u1ea9m \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng \u0111\u1ec3 \u0111i\u1ec1u tr\u1ecb b\u1ec7nh m\u00e1u kh\u00f3 \u0111\u00f4ng lo\u1ea1i A bao g\u1ed3m: (1) Desmopressin k\u00edch ho\u1ea1t gi\u1ea3i ph\u00f3ng ph\u1ee9c h\u1ee3p y\u1ebfu t\u1ed1 von Willebrand v\u00e0 y\u1ebfu t\u1ed1 VIII t\u1eeb c\u00e1c t\u1ebf b\u00e0o n\u1ed9i m\u00f4 m\u1ea1ch m\u00e1u \u0111\u1ec3 \u0111i\u1ec1u tr\u1ecb xu\u1ea5t huy\u1ebft \u1edf b\u1ec7nh nh\u00e2n Hemophilia A nh\u1eb9 \u0111\u1ebfn trung b\u00ecnh, (2) Acid tranexamic v\u00e0 Acid epsilon aminocaproic l\u00e0 c\u00e1c thu\u1ed1c \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng \u0111\u1ec3 gi\u1ea3m thi\u1ec3u xu\u1ea5t huy\u1ebft, (3) Truy\u1ec1n \u0111\u1ecbnh k\u1ef3 y\u1ebfu t\u1ed1 VIII c\u00f4 \u0111\u1eb7c c\u0169ng l\u00e0 m\u1ed9t ph\u01b0\u01a1ng ph\u00e1p \u0111i\u1ec1u tr\u1ecb d\u1ef1 ph\u00f2ng cho b\u1ec7nh nh\u00e2n Hemophilia A n\u1eb7ng<\/span><\/p>\n<h2><b>2.T\u1ed5ng quan v\u1ec1 thu\u1ed1c Altuviiio\u00a0<\/b><\/h2>\n<h3><span style=\"font-weight: 400;\">2.1 Gi\u1edbi thi\u1ec7u s\u01a1 l\u01b0\u1ee3c<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">C\u1ee5c Qu\u1ea3n l\u00fd Th\u1ef1c ph\u1ea9m v\u00e0 D\u01b0\u1ee3c ph\u1ea9m Hoa K\u1ef3 (FDA) \u0111\u00e3 ph\u00ea duy\u1ec7t Altuviiio \u0111\u1ec3 \u0111i\u1ec1u tr\u1ecb d\u1ef1 ph\u00f2ng \u0111\u1ecbnh k\u1ef3 v\u00e0 \u0111i\u1ec1u tr\u1ecb theo y\u00eau c\u1ea7u nh\u1eb1m ki\u1ec3m so\u00e1t c\u00e1c \u0111\u1ee3t xu\u1ea5t huy\u1ebft, c\u0169ng nh\u01b0 \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng trong ph\u1eabu thu\u1eadt ho ng\u01b0\u1eddi l\u1edbn v\u00e0 tr\u1ebb em m\u1eafc b\u1ec7nh \u01b0a ch\u1ea3y m\u00e1u lo\u1ea1i A. S\u1ef1 ch\u1ea5p thu\u1eadn c\u1ee7a FDA d\u1ef1a tr\u00ean d\u1eef li\u1ec7u t\u1eeb nghi\u00ean c\u1ee9u l\u00e2m s\u00e0ng XTEND-1 Giai \u0111o\u1ea1n 3 \u0111\u01b0\u1ee3c c\u00f4ng b\u1ed1 g\u1ea7n \u0111\u00e2y tr\u00ean T\u1ea1p ch\u00ed Y h\u1ecdc New England. K\u1ebft qu\u1ea3 cho th\u1ea5y r\u1eb1ng \u0111i\u1ec1u tr\u1ecb d\u1ef1 ph\u00f2ng b\u1eb1ng Altuviiio m\u1ed7i tu\u1ea7n m\u1ed9t l\u1ea7n gi\u00fap mang l\u1ea1i \u201cs\u1ef1 b\u1ea3o v\u1ec7 ch\u1ed1ng ch\u1ea3y m\u00e1u \u0111\u00e1ng k\u1ec3\u201d cho nh\u1eefng ng\u01b0\u1eddi m\u1eafc b\u1ec7nh m\u00e1u kh\u00f3 \u0111\u00f4ng lo\u1ea1i A n\u1eb7ng v\u1edbi t\u1ef7 l\u1ec7 ch\u1ea3y m\u00e1u trung b\u00ecnh h\u00e0ng n\u0103m (ABR) l\u00e0 0,70<\/span><\/p>\n<figure id=\"attachment_33621\" aria-describedby=\"caption-attachment-33621\" style=\"width: 237px\" class=\"wp-caption aligncenter\"><img decoding=\"async\" loading=\"lazy\" class=\"size-medium wp-image-33621\" src=\"http:\/\/noithathoaphat.in\/ctv\/wp-content\/uploads\/2023\/05\/Altuviiio-237x300.png\" alt=\"Altuviiio\" width=\"237\" height=\"300\" srcset=\"http:\/\/noithathoaphat.in\/ctv\/wp-content\/uploads\/2023\/05\/Altuviiio-237x300.png 237w, http:\/\/noithathoaphat.in\/ctv\/wp-content\/uploads\/2023\/05\/Altuviiio.png 481w\" sizes=\"(max-width: 237px) 100vw, 237px\" \/><figcaption id=\"caption-attachment-33621\" class=\"wp-caption-text\">Altuviiio<\/figcaption><\/figure>\n<h3><span style=\"font-weight: 400;\">2.2 Ch\u1ec9 \u0111\u1ecbnh\u00a0<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">Altuviiio l\u00e0 li\u1ec7u ph\u00e1p thay th\u1ebf <a href=\"http:\/\/noithathoaphat.in\/ctv\/wp-admin\/post.php?post=33028&amp;action=edit\">y\u1ebfu t\u1ed1 VIII<\/a> t\u00e1i t\u1ed5 h\u1ee3p d\u00f9ng m\u1ed9t l\u1ea7n m\u1ed7i tu\u1ea7n, c\u00f3 th\u1ec3 \u0111\u01b0\u1ee3c b\u1ec7nh nh\u00e2n Hemophilia A s\u1eed d\u1ee5ng th\u01b0\u1eddng xuy\u00ean \u0111\u1ec3 ng\u0103n ch\u1ea3y m\u00e1u ho\u1eb7c s\u1eed d\u1ee5ng theo y\u00eau c\u1ea7u \u0111\u1ec3 \u0111i\u1ec1u tr\u1ecb ch\u1ea3y m\u00e1u c\u1ea5p t\u00ednh. Altuviiio \u0111\u01b0\u1ee3c FDA ch\u1ea5p thu\u1eadn s\u1eed d\u1ee5ng cho ng\u01b0\u1eddi l\u1edbn v\u00e0 tr\u1ebb em m\u1eafc b\u1ec7nh m\u00e1u kh\u00f3 \u0111\u00f4ng A (thi\u1ebfu h\u1ee5t y\u1ebfu t\u1ed1 VIII b\u1ea9m sinh) trong c\u00e1c tr\u01b0\u1eddng h\u1ee3p:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">D\u1ef1 ph\u00f2ng th\u01b0\u1eddng quy \u0111\u1ec3 gi\u1ea3m t\u1ea7n su\u1ea5t ch\u1ea3y m\u00e1u<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">\u0110i\u1ec1u tr\u1ecb theo y\u00eau c\u1ea7u v\u00e0 ki\u1ec3m so\u00e1t c\u00e1c \u0111\u1ee3t ch\u1ea3y m\u00e1u<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">X\u1eed tr\u00ed ch\u1ea3y m\u00e1u chu ph\u1eabu<\/span><\/li>\n<\/ul>\n<p><span style=\"font-weight: 400;\">Altuviiio kh\u00f4ng \u0111\u01b0\u1ee3c ch\u1ec9 \u0111\u1ecbnh \u0111\u1ec3 \u0111i\u1ec1u tr\u1ecb b\u1ec7nh von Willebrand.<\/span><\/p>\n<h3><span style=\"font-weight: 400;\">2.3 C\u01a1 ch\u1ebf ho\u1ea1t \u0111\u1ed9ng c\u1ee7a Altuviiio trong b\u1ec7nh m\u00e1u kh\u00f3 \u0111\u00f4ng<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">Altuviiio l\u00e0 m\u1ed9t lo\u1ea1i dung h\u1ee3p protein \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng nh\u01b0 m\u1ed9t li\u1ec7u ph\u00e1p thay th\u1ebf y\u1ebfu t\u1ed1 VIII t\u00e1i t\u1ed5 h\u1ee3p ho\u1eb7c nh\u00e2n t\u1ea1o \u0111\u1ed9c l\u1eadp v\u1edbi y\u1ebfu t\u1ed1 von Willebrand (VWF). Altuviiio c\u00f3 ch\u1ee9a Fc-VWF-XTEN, l\u00e0 m\u1ed9t ph\u1ea7n c\u1ee7a y\u1ebfu t\u1ed1 von Willebrand, v\u00e0 c\u00f3 kh\u1ea3 n\u0103ng k\u00edch ho\u1ea1t h\u1ec7 th\u1ed1ng \u0111\u00f4ng m\u00e1u.<\/span><\/p>\n<h3><span style=\"font-weight: 400;\">2.4 Li\u1ec1u l\u01b0\u1ee3ng\u00a0<\/span><\/h3>\n<table>\n<tbody>\n<tr>\n<td>\n<p style=\"text-align: center;\"><b>M\u1ee5c \u0111\u00edch tr\u1ecb li\u1ec7u\u00a0<\/b><\/p>\n<\/td>\n<td>\n<p style=\"text-align: center;\"><b>Li\u1ec1u khuy\u1ebfn c\u00e1o<\/b><\/p>\n<\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">D\u1ef1 ph\u00f2ng \u0111\u1ecbnh k\u1ef3 (ng\u01b0\u1eddi l\u1edbn, tr\u1ebb em)<\/span><\/td>\n<td><span style=\"font-weight: 400;\">1 tu\u1ea7n \/ 1 l\u1ea7n<\/span><\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">\u0110i\u1ec1u tr\u1ecb theo y\u00eau c\u1ea7u v\u00e0 ki\u1ec3m so\u00e1t c\u00e1c \u0111\u1ee3t ch\u1ea3y m\u00e1u<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Li\u1ec1u ph\u1ee5 thu\u1ed9c v\u00e0o lo\u1ea1i ch\u1ea3y m\u00e1u (nh\u1eb9, trung b\u00ecnh ho\u1eb7c n\u1eb7ng)<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Ban \u0111\u1ea7u: c\u00e2n nh\u1eafc li\u1ec1u duy nh\u1ea5t\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Sau 2 \u2013 3 ng\u00e0y: li\u1ec1u b\u1ed5 sung\u00a0<\/span><\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">X\u1eed tr\u00ed ch\u1ea3y m\u00e1u chu ph\u1eabu\u00a0<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Li\u1ec1u l\u01b0\u1ee3ng ph\u1ee5 thu\u1ed9c v\u00e0o lo\u1ea1i ph\u1eabu thu\u1eadt<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Ban \u0111\u1ea7u: c\u00e2n nh\u1eafc li\u1ec1u duy nh\u1ea5t\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Sau 2 \u2013 3 ng\u00e0y: li\u1ec1u b\u1ed5 sung\u00a0<\/span><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p>&nbsp;<\/p>\n<h3><span style=\"font-weight: 400;\">2.5 T\u00e1c d\u1ee5ng ph\u1ee5\u00a0<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">C\u00e1c t\u00e1c d\u1ee5ng ph\u1ee5 ph\u1ed5 bi\u1ebfn khi s\u1eed d\u1ee5ng Altuviiio: s\u1ed1t, \u0111au \u0111\u1ea7u. M\u1ed9t s\u1ed1 t\u00e1c d\u1ee5ng ph\u1ee5 \u00edt ph\u1ed5 bi\u1ebfn h\u01a1n bao g\u1ed3m \u1edbn l\u1ea1nh, th\u1edf nhanh ho\u1eb7c kh\u00f4ng \u0111\u1ec1u, bu\u1ed3n n\u00f4n, b\u1ecdng m\u1eaft ho\u1eb7c s\u01b0ng m\u00ed m\u1eaft ho\u1eb7c quanh m\u1eaft, c\u1ea3m gi\u00e1c b\u1ecfng, \u1ea5m, n\u00f3ng, t\u00ea, c\u0103ng ho\u1eb7c ng\u1ee9a ran, ti\u00eau ch\u1ea3y, ch\u1ea3y m\u00e1u m\u0169i, \u0111\u1ecf m\u1eaft.<\/span><\/p>\n<h3><span style=\"font-weight: 400;\">2.6 C\u1ea3nh b\u00e1o\u00a0<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">Ph\u1ea3n \u1ee9ng qu\u00e1 m\u1eabn: C\u00e1c ph\u1ea3n \u1ee9ng qu\u00e1 m\u1eabn ki\u1ec3u d\u1ecb \u1ee9ng, bao g\u1ed3m c\u1ea3 s\u1ed1c ph\u1ea3n v\u1ec7, c\u00f3 th\u1ec3 x\u1ea3y ra khi s\u1eed d\u1ee5ng Altuviiio<\/span><\/p>\n<h2><b>3. K\u1ebft lu\u1eadn\u00a0<\/b><\/h2>\n<p><span style=\"font-weight: 400;\">T\u00f3m l\u1ea1i, Altuviiio l\u00e0 m\u1ed9t s\u1ef1 ti\u1ebfn b\u1ed9 m\u1edbi trong \u0111i\u1ec1u tr\u1ecb b\u1ec7nh m\u00e1u kh\u00f3 \u0111\u00f4ng lo\u1ea1i A. V\u1edbi kh\u1ea3 n\u0103ng \u0111\u1ed9c l\u1eadp v\u1edbi y\u1ebfu t\u1ed1 von Willebrand v\u00e0 th\u1eddi gian b\u00e1n h\u1ee7y k\u00e9o d\u00e0i, Altuviiio c\u00f3 th\u1ec3 gi\u00fap gi\u1ea3m thi\u1ec3u s\u1ed1 l\u01b0\u1ee3ng li\u1ec1u ti\u00eam v\u00e0 mang l\u1ea1i s\u1ef1 thu\u1eadn ti\u1ec7n cho b\u1ec7nh nh\u00e2n. C\u00e1c \u01b0u \u0111i\u1ec3m c\u1ee7a Altuviiio n\u00e0y cho th\u1ea5y ti\u1ec1m n\u0103ng l\u1edbn trong vi\u1ec7c c\u1ea3i thi\u1ec7n ch\u1ea5t l\u01b0\u1ee3ng cu\u1ed9c s\u1ed1ng c\u1ee7a b\u1ec7nh nh\u00e2n v\u00e0 n\u00e2ng cao hi\u1ec7u qu\u1ea3 \u0111i\u1ec1u tr\u1ecb b\u1ec7nh kh\u1edbp \u01b0a ch\u1ea3y m\u00e1u lo\u1ea1i A.<\/span><\/p>\n","protected":false},"excerpt":{"rendered":"<p>B\u1ec7nh m\u00e1u kh\u00f3 \u0111\u00f4ng lo\u1ea1i A l\u00e0 m\u1ed9t b\u1ec7nh di truy\u1ec1n g\u00e2y ra s\u1ef1 thi\u1ebfu h\u1ee5t y\u1ebfu t\u1ed1 VIII trong h\u1ec7 th\u1ed1ng \u0111\u00f4ng m\u00e1u. Trong nhi\u1ec1u n\u0103m qua, \u0111i\u1ec1u tr\u1ecb b\u1ec7nh n\u00e0y ch\u1ee7 y\u1ebfu d\u1ef1a v\u00e0o vi\u1ec7c s\u1eed d\u1ee5ng y\u1ebfu t\u1ed1 VIII thay th\u1ebf. Tuy nhi\u00ean, ti\u1ebfn b\u1ed9 m\u1edbi \u0111\u00e3 \u0111\u1ea1t \u0111\u01b0\u1ee3c v\u1edbi s\u1ef1 ra [&hellip;]<\/p>\n","protected":false},"author":54,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[12],"tags":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v20.4 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Altuviiio: B\u01b0\u1edbc ti\u1ebfn m\u1edbi trong \u0111i\u1ec1u tr\u1ecb m\u00e1u kh\u00f3 \u0111\u00f4ng lo\u1ea1i A - Vinmec<\/title>\n<meta name=\"description\" content=\"Altuviiio l\u00e0 m\u1ed9t s\u1ef1 ti\u1ebfn b\u1ed9 m\u1edbi trong \u0111i\u1ec1u tr\u1ecb b\u1ec7nh m\u00e1u kh\u00f3 \u0111\u00f4ng lo\u1ea1i A. H\u01a1n n\u1eefa thu\u1ed1c c\u00f3 th\u1eddi gian k\u00e9o d\u00e0i n\u00ean r\u1ea5t ti\u1ec7n l\u1ee3i khi s\u1eed d\u1ee5ng\" \/>\n<meta name=\"robots\" content=\"noindex, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Altuviiio: B\u01b0\u1edbc ti\u1ebfn m\u1edbi trong \u0111i\u1ec1u tr\u1ecb m\u00e1u kh\u00f3 \u0111\u00f4ng lo\u1ea1i A - Vinmec\" \/>\n<meta property=\"og:description\" content=\"Altuviiio l\u00e0 m\u1ed9t s\u1ef1 ti\u1ebfn b\u1ed9 m\u1edbi trong \u0111i\u1ec1u tr\u1ecb b\u1ec7nh m\u00e1u kh\u00f3 \u0111\u00f4ng lo\u1ea1i A. 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