{"id":32917,"date":"2023-05-13T14:43:09","date_gmt":"2023-05-13T07:43:09","guid":{"rendered":"http:\/\/noithathoaphat.in\/ctv\/?p=32917"},"modified":"2023-05-13T14:43:09","modified_gmt":"2023-05-13T07:43:09","slug":"viem-phoi-ke","status":"publish","type":"post","link":"http:\/\/noithathoaphat.in\/ctv\/index.php\/2023\/05\/13\/viem-phoi-ke\/","title":{"rendered":"Vi\u00eam ph\u1ed5i k\u1ebd: Ch\u1ea9n \u0111o\u00e1n v\u00e0 \u0111i\u1ec1u tr\u1ecb"},"content":{"rendered":"<p><strong>Vi\u00eam ph\u1ed5i k\u1ebd (Interstitial Lung Diseases) l\u00e0 t\u00ecnh tr\u1ea1ng b\u1ec7nh l\u00fd ph\u1ee9c t\u1ea1p, c\u00f3 th\u1ec3 g\u00e2y ra nhi\u1ec1u bi\u1ebfn ch\u1ee9ng nghi\u00eam tr\u1ecdng v\u00e0 \u1ea3nh h\u01b0\u1edfng \u0111\u1ebfn ch\u1ea5t l\u01b0\u1ee3ng cu\u1ed9c s\u1ed1ng c\u1ee7a ng\u01b0\u1eddi b\u1ec7nh. B\u1ec7nh l\u00fd n\u00e0y c\u00f3 th\u1ec3 x\u1ea3y ra \u1edf m\u1ecdi \u0111\u1ed9 tu\u1ed5i, nh\u01b0ng th\u01b0\u1eddng \u1ea3nh h\u01b0\u1edfng \u0111\u1ebfn ng\u01b0\u1eddi gi\u00e0, tr\u1ebb em v\u00e0 nh\u1eefng ng\u01b0\u1eddi c\u00f3 h\u1ec7 mi\u1ec5n d\u1ecbch y\u1ebfu.<\/strong><\/p>\n<h1><strong>1. \u0110\u1ea1i c\u01b0\u01a1ng<\/strong><\/h1>\n<p>Vi\u00eam ph\u1ed5i k\u1ebd l\u00e0 thu\u1eadt ng\u1eef ch\u1ec9 nh\u1eefng b\u1ec7nh ph\u1ed5i c\u00f3 t\u1ed5n th\u01b0\u01a1ng \u1edf kho\u1ea3ng k\u1ebd \u1edf ph\u1ed5i, b\u1ec7nh th\u01b0\u1eddng lan t\u1ecfa, t\u1ed5n th\u01b0\u01a1ng kh\u00f4ng \u0111\u1ed3ng nh\u1ea5t, tuy nhi\u00ean, \u0111\u01b0\u1ee3c x\u1ebfp chung v\u00e0o m\u1ed9t nh\u00f3m do c\u00f3 bi\u1ec3u hi\u1ec7n l\u00e2m s\u00e0ng, X-quang ph\u1ed5i, t\u1ed5n th\u01b0\u01a1ng m\u00f4 b\u1ec7nh h\u1ecdc g\u1ea7n t\u01b0\u01a1ng t\u1ef1 nhau.<\/p>\n<figure id=\"attachment_32918\" aria-describedby=\"caption-attachment-32918\" style=\"width: 700px\" class=\"wp-caption aligncenter\"><img decoding=\"async\" loading=\"lazy\" class=\"wp-image-32918\" src=\"http:\/\/noithathoaphat.in\/ctv\/wp-content\/uploads\/2023\/05\/1-5.jpg\" alt=\"\" width=\"700\" height=\"760\" srcset=\"http:\/\/noithathoaphat.in\/ctv\/wp-content\/uploads\/2023\/05\/1-5.jpg 475w, http:\/\/noithathoaphat.in\/ctv\/wp-content\/uploads\/2023\/05\/1-5-276x300.jpg 276w\" sizes=\"(max-width: 700px) 100vw, 700px\" \/><figcaption id=\"caption-attachment-32918\" class=\"wp-caption-text\"><strong>\u00a0 \u00a0 \u00a0 \u00a0 \u00a0Ngu\u1ed3n: What Are Interstitial Lung Diseases? &#8211; National Heart, Lung, and Blood Institute<\/strong><\/figcaption><\/figure>\n<h2><strong>2. Ch\u1ea9n \u0111o\u00e1n<\/strong><\/h2>\n<h3><strong>2.1. Tri\u1ec7u ch\u1ee9ng l\u00e2m s\u00e0ng<\/strong><\/h3>\n<p>H\u1ea7u h\u1ebft c\u00e1c tri\u1ec7u ch\u1ee9ng c\u1ee7a vi\u00eam ph\u1ed5i k\u1ebd kh\u00f4ng \u0111\u1eb7c hi\u1ec7u. Tuy nhi\u00ean, vi\u1ec7c khai th\u00e1c k\u1ef9 ti\u1ec1n s\u1eed ti\u1ebfp x\u00fac y\u1ebfu t\u1ed1 nguy c\u01a1, ti\u1ec1n s\u1eed b\u1ec7nh, c\u00e1c tri\u1ec7u ch\u1ee9ng l\u00e2m s\u00e0ng gi\u00fap kh\u1eb3ng \u0111\u1ecbnh ch\u1ea9n \u0111o\u00e1n. C\u1ea7n khai th\u00e1c chi ti\u1ebft v\u1ec1 kho\u1ea3ng th\u1eddi gian, m\u1ee9c \u0111\u1ed9 n\u1eb7ng v\u00e0 ti\u1ebfn tri\u1ec3n c\u1ee7a tri\u1ec7u ch\u1ee9ng.<\/p>\n<p>C\u00e1c tri\u1ec7u ch\u1ee9ng c\u1ee7a b\u1ec7nh<\/p>\n<p>&#8211; Kh\u00f3 th\u1edf: th\u01b0\u1eddng b\u1eaft \u0111\u1ea7u t\u1eeb t\u1eeb, kh\u00f3 th\u1edf g\u1eafng s\u1ee9c, t\u0103ng d\u1ea7n. M\u1ed9t s\u1ed1 \u00edt tr\u01b0\u1eddng h\u1ee3p c\u00f3 kh\u1edfi ph\u00e1t c\u1ea5p t\u00ednh.<\/p>\n<p>&#8211; Ho: th\u01b0\u1eddng l\u00e0 ho khan. C\u00f3 th\u1ec3 g\u1eb7p ho m\u00e1u trong h\u1ed9i ch\u1ee9ng ch\u1ea3y m\u00e1u lan t\u1ecfa ph\u1ebf nang, b\u1ec7nh van hai l\u00e1.<\/p>\n<p>&#8211; C\u00e1c tri\u1ec7u ch\u1ee9ng hi\u1ebfm g\u1eb7p kh\u00e1c nh\u01b0: th\u1edf r\u00edt, \u0111au ng\u1ef1c<\/p>\n<p>&#8211; C\u00e1c tri\u1ec7u ch\u1ee9ng ngo\u00e0i ph\u1ed5i: l\u00e0 bi\u1ec3u hi\u1ec7n quan tr\u1ecdng gi\u00fap g\u1ee3i \u00fd ch\u1ea9n \u0111o\u00e1n b\u1ec7nh t\u1ed5 ch\u1ee9c li\u00ean k\u1ebft: \u0111au c\u01a1, x\u01b0\u01a1ng, m\u1ec7t m\u1ecfi, s\u1ed1t, \u0111au kh\u1edbp, ph\u00f9, da nh\u1ea1y c\u1ea3m v\u1edbi \u00e1nh s\u00e1ng, kh\u00f4 m\u1eaft, kh\u00f4 mi\u1ec7ng. Tuy nhi\u00ean, khi kh\u00f4ng c\u00f3 c\u00e1c tri\u1ec7u ch\u1ee9ng n\u00e0y c\u0169ng kh\u00f4ng lo\u1ea1i tr\u1eeb \u0111\u01b0\u1ee3c c\u00e1c b\u1ec7nh t\u1ed5 ch\u1ee9c li\u00ean k\u1ebft.<\/p>\n<p>&#8211; Khai th\u00e1c k\u1ef9 c\u00e1c y\u1ebfu t\u1ed1 nh\u01b0: ti\u1ec1n s\u1eed ngh\u1ec1 nghi\u1ec7p, b\u1ec7nh h\u1ec7 th\u1ed1ng, d\u00f9ng thu\u1ed1c, x\u1ea1 tr\u1ecb, h\u00fat thu\u1ed1c&#8230;<\/p>\n<p>&#8211; Kh\u00e1m b\u1ec7nh:<\/p>\n<p>+ C\u00e1c d\u1ea5u hi\u1ec7u t\u1ea1i ph\u1ed5i: ran n\u1ed5, \u1ea9m nh\u1ecf h\u1ea1t \u1edf \u0111\u00e1y ph\u1ed5i hai b\u00ean.<\/p>\n<p>+ C\u00e1c d\u1ea5u hi\u1ec7u ngo\u00e0i ph\u1ed5i: l\u00e0 c\u00e1c d\u1ea5u hi\u1ec7u c\u1ee7a c\u0103n nguy\u00ean g\u00e2y b\u1ec7nh nh\u01b0: ph\u00f9 ch\u00e2n, c\u00e1c d\u1ea5u hi\u1ec7u b\u1ec7nh l\u00fd tim m\u1ea1ch, c\u00e1c bi\u1ec3u hi\u1ec7n c\u01a1, x\u01b0\u01a1ng, kh\u1edbp, da. C\u00f3 th\u1ec3 th\u1ea5y c\u00e1c d\u1ea5u hi\u1ec7u kh\u00e1c g\u1ee3i \u00fd suy h\u00f4 h\u1ea5p nh\u01b0: t\u00edm m\u00f4i, \u0111\u1ea7u chi.. ho\u1eb7c ng\u00f3n d\u00f9i tr\u1ed1ng.<\/p>\n<h3><strong>2.2. Tri\u1ec7u ch\u1ee9ng c\u1eadn l\u00e2m s\u00e0ng<\/strong><\/h3>\n<p>T\u00f9y theo t\u1eebng b\u1ec7nh c\u1ea3nh l\u00e2m s\u00e0ng \u0111\u1ec3 ch\u1ec9 \u0111\u1ecbnh x\u00e9t nghi\u1ec7m cho ph\u00f9 h\u1ee3p, c\u00e1c x\u00e9t nghi\u1ec7m bao g\u1ed3m:<\/p>\n<p>&#8211; X\u00e9t nghi\u1ec7m m\u00e1u: CK, AST, ALT, creatinin, c\u00f4ng th\u1ee9c m\u00e1u, t\u1ed5ng ph\u00e2n t\u00edch n\u01b0\u1edbc ti\u1ec3u, HIV.<\/p>\n<p>&#8211; C\u00e1c x\u00e9t nghi\u1ec7m t\u00ecm c\u00e1c b\u1ec7nh t\u1ef1 mi\u1ec5n: kh\u00e1ng th\u1ec3 kh\u00e1ng nh\u00e2n (ANA), y\u1ebfu t\u1ed1 d\u1ea1ng th\u1ea5p (RF) kh\u00e1ng th\u1ec3 kh\u00e1ng topoisomerase (anti-Scl70), kh\u00e1ng b\u00e0o t\u01b0\u01a1ng b\u1ea1ch c\u1ea7u \u0111a nh\u00e2n trung t\u00ednh (ANCA), kh\u00e1ng th\u1ec3 kh\u00e1ng JO-1. Khi b\u1ec7nh nh\u00e2n c\u00f3 ANA d\u01b0\u01a1ng t\u00ednh: c\u00f3 th\u1ec3 l\u00e0m th\u00eam: kh\u00e1ng th\u1ec3 kh\u00e1ng DNA, kh\u00e1ng th\u1ec3 kh\u00e1ng nh\u00e2n t\u1ebf b\u00e0o (anti-Sm, anti-ribonucleoprotein). V\u1edbi b\u1ec7nh nh\u00e2n c\u00f3 ch\u1ea3y m\u00e1u nhu m\u00f4 ph\u1ed5i c\u1ea7n l\u00e0m th\u00eam: kh\u00e1ng th\u1ec3 kh\u00e1ng m\u00e0ng \u0111\u00e1y, ANCA, ANA, kh\u00e1ng th\u1ec3 kh\u00e1ng phospholipid v\u00e0 c\u00e1c kh\u00e1ng th\u1ec3 kh\u00e1ng streptococcus.<\/p>\n<p><strong>B\u1ea3ng 1:<\/strong>\u00a0B\u1ea5t th\u01b0\u1eddng x\u00e9t nghi\u1ec7m v\u00e0 b\u1ec7nh ph\u1ed5i k\u1ebd<\/p>\n<table width=\"0\">\n<tbody>\n<tr>\n<td width=\"30%\"><strong>B\u1ea5t th\u01b0\u1eddng<\/strong><\/td>\n<td width=\"69%\"><strong>B\u1ec7nh li\u00ean quan<\/strong><\/td>\n<\/tr>\n<tr>\n<td width=\"30%\">Gi\u1ea3m b\u1ea1ch c\u1ea7u<\/td>\n<td width=\"69%\">B\u1ec7nh sacoit, b\u1ec7nh t\u1ed5 ch\u1ee9c li\u00ean k\u1ebft, u lympho, b\u1ec7nh ph\u1ed5i do thu\u1ed1c<\/td>\n<\/tr>\n<tr>\n<td width=\"30%\">T\u0103ng b\u1ea1ch c\u1ea7u<\/td>\n<td width=\"69%\">Vi\u00eam ph\u1ed5i t\u0103ng c\u1ea3m, u lympho, vi\u00eam m\u1ea1ch h\u1ec7 th\u1ed1ng<\/td>\n<\/tr>\n<tr>\n<td width=\"30%\">T\u0103ng b\u1ea1ch c\u1ea7u \u00e1i toan<\/td>\n<td width=\"69%\">Vi\u00eam ph\u1ed5i t\u0103ng b\u1ea1ch c\u1ea7u \u00e1i toan, b\u1ec7nh sacoit, vi\u00eam m\u1ea1ch h\u1ec7 th\u1ed1ng, b\u1ec7nh ph\u1ed5i do thu\u1ed1c (sulfasalazin, methotrexat)<\/td>\n<\/tr>\n<tr>\n<td width=\"30%\">Gi\u1ea3m ti\u1ec3u c\u1ea7u<\/td>\n<td width=\"69%\">B\u1ec7nh sacoit, b\u1ec7nh t\u1ed5 ch\u1ee9c li\u00ean k\u1ebft, b\u1ec7nh ph\u1ed5i do thu\u1ed1c, b\u1ec7nh Gaucher.<\/td>\n<\/tr>\n<tr>\n<td width=\"30%\">Thi\u1ebfu m\u00e1u tan huy\u1ebft<\/td>\n<td width=\"69%\">B\u1ec7nh t\u1ed5 ch\u1ee9c li\u00ean k\u1ebft<\/td>\n<\/tr>\n<tr>\n<td width=\"30%\">Thi\u1ebfu m\u00e1u<\/td>\n<td width=\"69%\">H\u1ed9i ch\u1ee9ng ch\u1ea3y m\u00e1u ph\u1ebf nang lan t\u1ecfa, b\u1ec7nh t\u1ed5 ch\u1ee9c li\u00ean k\u1ebft, ung th\u01b0 b\u1ea1ch m\u1ea1ch<\/td>\n<\/tr>\n<tr>\n<td width=\"30%\">T\u0103ng calci m\u00e1u<\/td>\n<td width=\"69%\">B\u1ec7nh sacoit, ung th\u01b0 b\u1ea1ch m\u1ea1ch<\/td>\n<\/tr>\n<tr>\n<td width=\"30%\">Gi\u1ea3m gammaglobulin m\u00e1u<\/td>\n<td width=\"69%\">Vi\u00eam ph\u1ed5i k\u1ebd b\u1ea1ch m\u1ea1ch<\/td>\n<\/tr>\n<tr>\n<td width=\"30%\">T\u0103ng gammaglobulin m\u00e1u<\/td>\n<td width=\"69%\">B\u1ec7nh t\u1ed5 ch\u1ee9c li\u00ean k\u1ebft, b\u1ec7nh sacoit, vi\u00eam m\u1ea1ch h\u1ec7 th\u1ed1ng, vi\u00eam ph\u1ed5i k\u1ebd b\u1ea1ch m\u1ea1ch, u lympho, b\u1ee5i ph\u1ed5i<\/td>\n<\/tr>\n<tr>\n<td width=\"30%\">Kh\u00e1ng th\u1ec3 kh\u00e1ng m\u00e0ng \u0111\u00e1y<\/td>\n<td width=\"69%\">H\u1ed9i ch\u1ee9ng Goodpasture<\/td>\n<\/tr>\n<tr>\n<td width=\"30%\">Kh\u00e1ng th\u1ec3 kh\u00e1ng t\u01b0\u01a1ng b\u00e0o b\u1ea1ch c\u1ea7u \u0111a nh\u00e2n trung t\u00ednh<\/td>\n<td width=\"69%\">U h\u1ea1t Wegener, h\u1ed9i ch\u1ee9ng Churg-Strauss<\/td>\n<\/tr>\n<tr>\n<td width=\"30%\">T\u0103ng LDH<\/td>\n<td width=\"69%\">B\u1ec7nh t\u00edch protein ph\u1ebf nang, x\u01a1 ph\u1ed5i t\u1ef1 ph\u00e1t<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p>&#8211; X-quang ph\u1ed5i: C\u00e1c bi\u1ec3u hi\u1ec7n th\u1ea5y bao g\u1ed3m: t\u1ed5n th\u01b0\u01a1ng d\u1ea1ng l\u01b0\u1edbi, n\u1ed1t, k\u00ednh m\u1edd, h\u00ecnh t\u1ed5 ong.<\/p>\n<p>&#8211; C\u1eaft l\u1edbp vi t\u00ednh ng\u1ef1c (CLVT): Ch\u1ee5p l\u1edbp m\u1ecfng, \u0111\u1ed9 ph\u00e2n gi\u1ea3i cao (HRCT), c\u00e1c h\u00ecnh \u1ea3nh c\u00f3 th\u1ec3 g\u1eb7p tr\u00ean CLVT ng\u1ef1c bao g\u1ed3m:<\/p>\n<p><strong><em>\u2666 \u0110\u1eb7c \u0111i\u1ec3m ch\u1ee5p CLVT \u0111\u1ed9 ph\u00e2n gi\u1ea3i cao trong b\u1ec7nh ph\u1ed5i k\u1ebd<\/em><\/strong><\/p>\n<p>* Ph\u00e2n b\u1ed1 t\u1ed5n th\u01b0\u01a1ng trong ph\u1ed5i<\/p>\n<p>+ Ngo\u1ea1i vi<\/p>\n<ul>\n<li>X\u01a1 ph\u1ed5i k\u1ebd t\u1ef1 ph\u00e1t<\/li>\n<li>B\u1ec7nh ph\u1ed5i nhi\u1ec5m amiang<\/li>\n<li>B\u1ec7nh t\u1ed5 ch\u1ee9c li\u00ean k\u1ebft<\/li>\n<li>Vi\u00eam ph\u1ed5i t\u1ed5 ch\u1ee9c h\u00f3a t\u1eafc ngh\u1ebdn ti\u1ec3u ph\u1ebf qu\u1ea3n<\/li>\n<li>Vi\u00eam ph\u1ed5i t\u0103ng b\u1ea1ch c\u1ea7u \u00e1i toan<\/li>\n<\/ul>\n<p>+ Trung t\u00e2m (t\u0103ng \u0111\u1eadm m\u1ea1ch m\u00e1u ph\u1ebf qu\u1ea3n)<\/p>\n<ul>\n<li>B\u1ec7nh sacoit<\/li>\n<li>Ung th\u01b0 b\u1ea1ch m\u1ea1ch<\/li>\n<\/ul>\n<p>+ Ph\u00eda tr\u00ean c\u1ee7a ph\u1ed5i<\/p>\n<ul>\n<li>B\u1ec7nh u h\u1ea1t ph\u1ed5i: B\u1ec7nh sacoit, vi\u00eam ph\u1ed5i t\u0103ng c\u1ea3m m\u1ea1n t\u00ednh, lao ph\u1ed5i, histoplasmosis.<\/li>\n<li>B\u1ec7nh b\u1ee5i ph\u1ed5i<\/li>\n<\/ul>\n<p>+ Ph\u00eda d\u01b0\u1edbi c\u1ee7a ph\u1ed5i<\/p>\n<ul>\n<li>X\u01a1 ph\u1ed5i k\u1ebd t\u1ef1 ph\u00e1t<\/li>\n<li>Vi\u00eam ph\u1ed5i trong vi\u00eam kh\u1edbp d\u1ea1ng th\u1ea5p<\/li>\n<li>B\u1ec7nh nhi\u1ec5m amiang ph\u1ed5i<\/li>\n<\/ul>\n<p>* C\u00e1c d\u1ea1ng t\u1ed5n th\u01b0\u01a1ng trong ph\u1ed5i.<\/p>\n<p>&#8211; T\u1ed5n th\u01b0\u01a1ng m\u1edd ph\u1ebf nang<\/p>\n<p>+ H\u00ecnh k\u00ednh m\u1edd<\/p>\n<ul>\n<li>Vi\u00eam ph\u1ed5i t\u0103ng c\u1ea3m<\/li>\n<li>Vi\u00eam ph\u1ed5i k\u1ebd bong v\u1ea3y<\/li>\n<li>Vi\u00eam ph\u1ed5i do thu\u1ed1c<\/li>\n<li>Ch\u1ea3y m\u00e1u ph\u1ed5i<\/li>\n<\/ul>\n<p>+ \u0110\u00f4ng \u0111\u1eb7c ph\u1ed5i<\/p>\n<ul>\n<li>Vi\u00eam ph\u1ed5i t\u0103ng b\u1ea1ch c\u1ea7u \u00e1i toan c\u1ea5p ho\u1eb7c m\u1ea1n t\u00ednh<\/li>\n<li>Vi\u00eam ph\u1ed5i t\u1ed5 ch\u1ee9c h\u00f3a t\u1eafc ngh\u1ebdn ti\u1ec3u ph\u1ebf qu\u1ea3n<\/li>\n<li>Vi\u00eam ph\u1ed5i h\u00edt ph\u1ea3i<\/li>\n<li>Ung th\u01b0 ph\u1ebf nang<\/li>\n<li>U lympho<\/li>\n<li>B\u1ec7nh t\u00edch protein ph\u1ebf nang<\/li>\n<\/ul>\n<p>&#8211; T\u1ed5n th\u01b0\u01a1ng l\u01b0\u1edbi<\/p>\n<ul>\n<li>X\u01a1 ph\u1ed5i k\u1ebd t\u1ef1 ph\u00e1t<\/li>\n<li>Nhi\u1ec5m amiang ph\u1ed5i<\/li>\n<li>B\u1ec7nh t\u1ed5 ch\u1ee9c li\u00ean k\u1ebft<\/li>\n<li>Vi\u00eam ph\u1ed5i t\u0103ng c\u1ea3m<\/li>\n<\/ul>\n<p>&#8211; T\u1ed5n th\u01b0\u01a1ng n\u1ed1t<\/p>\n<p>+ Vi\u00eam ph\u1ed5i t\u0103ng c\u1ea3m<\/p>\n<ul>\n<li>B\u1ec7nh sacoit<\/li>\n<li>B\u1ec7nh m\u00f4 b\u00e0o Langerhan ph\u1ed5i<\/li>\n<li>B\u1ee5i ph\u1ed5i<\/li>\n<li>Ung th\u01b0 di c\u0103n ph\u1ed5i<\/li>\n<\/ul>\n<p>&#8211; \u0110\u00e1nh gi\u00e1 b\u1ec7nh tim m\u1ea1ch: \u0110i\u1ec7n tim, si\u00eau \u00e2m tim, ProBNP.<\/p>\n<p>&#8211; Ch\u1ee9c n\u0103ng h\u00f4 h\u1ea5p: Th\u01b0\u1eddng g\u1eb7p r\u1ed1i lo\u1ea1n th\u00f4ng kh\u00ed h\u1ea1n ch\u1ebf, tuy nhi\u00ean, c\u0169ng c\u00f3 th\u1ec3 g\u1eb7p r\u1ed1i lo\u1ea1n th\u00f4ng kh\u00ed t\u1eafc ngh\u1ebdn trong m\u1ed9t s\u1ed1 tr\u01b0\u1eddng h\u1ee3p nh\u01b0: b\u1ec7nh sacoit, Lymphangioleiomyomatosis, vi\u00eam ph\u1ed5i t\u0103ng c\u1ea3m, b\u1ec7nh m\u00f4 b\u00e0o Langerhans ph\u1ed5i, c\u00e1c tr\u01b0\u1eddng h\u1ee3p c\u00f3 BPTNMT k\u00e8m theo.<\/p>\n<p>&#8211; Kh\u00ed m\u00e1u \u0111\u1ed9ng m\u1ea1ch v\u00e0 DLCO: C\u00f3 gi\u00e1 tr\u1ecb g\u00f3p ph\u1ea7n ti\u00ean l\u01b0\u1ee3ng b\u1ec7nh.<\/p>\n<p>&#8211; R\u1eeda ph\u1ebf qu\u1ea3n ph\u1ebf nang qua n\u1ed9i soi ph\u1ebf qu\u1ea3n l\u1ea5y d\u1ecbch l\u00e0m c\u00e1c x\u00e9t nghi\u1ec7m: T\u1ebf b\u00e0o, c\u1ea5y t\u00ecm tr\u1ef1c khu\u1ea9n lao, vi khu\u1ea9n th\u01b0\u1eddng, n\u1ea5m, virus, \u0111\u1ecbnh l\u01b0\u1ee3ng protein (trong b\u1ec7nh t\u00edch protein ph\u1ebf nang).<\/p>\n<p>&#8211; Sinh thi\u1ebft ph\u1ed5i: C\u00e1c ph\u01b0\u01a1ng ph\u00e1p sinh thi\u1ebft ph\u1ed5i th\u01b0\u1eddng \u0111\u01b0\u1ee3c ch\u1ec9 \u0111\u1ecbnh: sinh thi\u1ebft ph\u1ed5i qua n\u1ed9i soi ph\u1ebf qu\u1ea3n, n\u1ed9i soi l\u1ed3ng ng\u1ef1c ho\u1eb7c sinh thi\u1ebft ph\u1ed5i m\u1edf. Nh\u00ecn chung, sinh thi\u1ebft ph\u1ed5i qua n\u1ed9i soi l\u1ed3ng ng\u1ef1c ho\u1eb7c sinh thi\u1ebft ph\u1ed5i m\u1edf c\u00f3 gi\u00e1 tr\u1ecb h\u01a1n trong ch\u1ea9n \u0111o\u00e1n.<\/p>\n<figure id=\"attachment_32920\" aria-describedby=\"caption-attachment-32920\" style=\"width: 700px\" class=\"wp-caption aligncenter\"><img decoding=\"async\" loading=\"lazy\" class=\"wp-image-32920\" src=\"http:\/\/noithathoaphat.in\/ctv\/wp-content\/uploads\/2023\/05\/3-2.jpg\" alt=\"\" width=\"700\" height=\"487\" srcset=\"http:\/\/noithathoaphat.in\/ctv\/wp-content\/uploads\/2023\/05\/3-2.jpg 467w, http:\/\/noithathoaphat.in\/ctv\/wp-content\/uploads\/2023\/05\/3-2-300x209.jpg 300w\" sizes=\"(max-width: 700px) 100vw, 700px\" \/><figcaption id=\"caption-attachment-32920\" class=\"wp-caption-text\"><strong>\u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0Ngu\u1ed3n: Interstitial lung disease research &#8211; University Bristol<\/strong><\/figcaption><\/figure>\n<p><strong>2.3. Ch\u1ea9n \u0111o\u00e1n nguy\u00ean nh\u00e2n vi\u00eam ph\u1ed5i k\u1ebd<\/strong><\/p>\n<p><strong><em>\u2666 B\u1ec7nh t\u1ed5 ch\u1ee9c li\u00ean k\u1ebft<\/em><\/strong><\/p>\n<p>&#8211; X\u01a1 c\u1ee9ng b\u00ec.<\/p>\n<p>&#8211; Vi\u00eam da c\u01a1 &#8211; vi\u00eam \u0111a c\u01a1.<\/p>\n<p>&#8211; Luput ban \u0111\u1ecf h\u1ec7 th\u1ed1ng.<\/p>\n<p>&#8211; Vi\u00eam kh\u1edbp d\u1ea1ng th\u1ea5p.<\/p>\n<p>&#8211; B\u1ec7nh t\u1ed5 ch\u1ee9c li\u00ean k\u1ebft h\u1ed7n h\u1ee3p.<\/p>\n<p><strong><em>\u2666 Do thu\u1ed1c<\/em><\/strong><\/p>\n<p>&#8211; Thu\u1ed1c kh\u00e1ng sinh: nitrofurantoin, sulfasalazin.<\/p>\n<p>&#8211; Thu\u1ed1c ch\u1ed1ng lo\u1ea1n nh\u1ecbp tim: amiodaron, tocainid, propranolol.<\/p>\n<p>&#8211; Thu\u1ed1c kh\u00e1ng vi\u00eam: gold, penicillamin.<\/p>\n<p>&#8211; Thu\u1ed1c ch\u1ed1ng co gi\u1eadt: dilantin.<\/p>\n<p>&#8211; H\u00f3a ch\u1ea5t ch\u1ed1ng ung th\u01b0: mitomycin C, bleomycin, busulfan, cyclophosphamid, chlorambucil, methotrexat, azathioprin, carmustin, procarbazin.<\/p>\n<p>&#8211; X\u1ea1 tr\u1ecb.<\/p>\n<p>&#8211; Ng\u1ed9 \u0111\u1ed9c oxy.<\/p>\n<p>&#8211; Thu\u1ed1c an th\u1ea7n.<\/p>\n<p><strong><em>\u2666 C\u00e1c b\u1ec7nh nguy\u00ean ph\u00e1t<\/em><\/strong><\/p>\n<p>&#8211; B\u1ec7nh sacoit.<\/p>\n<p>&#8211; B\u1ec7nh m\u00f4 b\u00e0o Langerhans ph\u1ed5i.<\/p>\n<p>&#8211; B\u1ec7nh amyloid.<\/p>\n<p>&#8211; Vi\u00eam m\u1ea1ch ph\u1ed5i.<\/p>\n<p>&#8211; Vi\u00eam ph\u1ed5i lipoid.<\/p>\n<p>&#8211; Ung th\u01b0 b\u1ea1ch m\u1ea1ch.<\/p>\n<p>&#8211; Ung th\u01b0 ph\u1ebf qu\u1ea3n ph\u1ebf nang.<\/p>\n<p>&#8211; B\u1ec7nh Gaucher.<\/p>\n<p>&#8211; B\u1ec7nh Niemann-Pick.<\/p>\n<p>&#8211; H\u1ed9i ch\u1ee9ng Hermansky-Pudlak.<\/p>\n<p>&#8211; Lymphangioleiomyomatosis.<\/p>\n<p>&#8211; H\u1ed9i ch\u1ee9ng tr\u1ee5y h\u00f4 h\u1ea5p c\u1ea5p t\u00ednh.<\/p>\n<p>&#8211; H\u1ed9i ch\u1ee9ng suy gi\u1ea3m mi\u1ec5n d\u1ecbch m\u1eafc ph\u1ea3i.<\/p>\n<p>&#8211; Vi\u00eam ph\u1ed5i t\u0103ng b\u1ea1ch c\u1ea7u \u00e1i toan.<\/p>\n<p>&#8211; H\u1ed9i ch\u1ee9ng xu\u1ea5t huy\u1ebft ph\u1ed5i lan t\u1ecfa.<\/p>\n<p>&#8211; B\u1ec7nh vi s\u1ecfi ph\u1ebf nang.<\/p>\n<p>&#8211; Ung th\u01b0 ph\u1ed5i th\u1ee9 ph\u00e1t.<\/p>\n<p>&#8211; B\u1ec7nh ph\u1ed5i m\u00f4i tr\u01b0\u1eddng v\u00e0 ngh\u1ec1 nghi\u1ec7p.<\/p>\n<p><strong><em>\u2666 B\u1ec7nh ph\u1ed5i m\u00f4i tr\u01b0\u1eddng v\u00e0 ngh\u1ec1 nghi\u1ec7p<\/em><\/strong><\/p>\n<p>&#8211; B\u1ee5i v\u00f4 c\u01a1.<\/p>\n<p>+ B\u1ee5i ph\u1ed5i.<\/p>\n<p>+ Nhi\u1ec5m amiang ph\u1ed5i.<\/p>\n<p>+ B\u1ec7nh ph\u1ed5i kim lo\u1ea1i n\u1eb7ng.<\/p>\n<p>+ B\u1ee5i than ph\u1ed5i.<\/p>\n<p>&#8211; B\u1ee5i h\u1eefu c\u01a1: vi\u00eam ph\u1ed5i t\u0103ng c\u1ea3m.<\/p>\n<p>\u2666\u00a0<strong><em>B\u1ec7nh ph\u1ed5i x\u01a1 h\u00f3a t\u1ef1 ph\u00e1t:<\/em><\/strong>\u00a0Trong \u0111\u00f3 ch\u1ee7 y\u1ebfu l\u00e0 x\u01a1 ph\u1ed5i t\u1ef1 ph\u00e1t v\u00e0 vi\u00eam ph\u1ed5i k\u1ebd kh\u00f4ng \u0111\u1eb7c hi\u1ec7u.<\/p>\n<p>&#8211; Vi\u00eam ph\u1ed5i k\u1ebd c\u1ea5p t\u00ednh: H\u1ed9i ch\u1ee9ng Hamman-Rich.<\/p>\n<p>&#8211; X\u01a1 ph\u1ed5i t\u1ef1 ph\u00e1t (vi\u00eam ph\u1ed5i k\u1ebd th\u00f4ng th\u01b0\u1eddng).<\/p>\n<p>&#8211; X\u01a1 ph\u1ed5i gia \u0111\u00ecnh.<\/p>\n<p>&#8211; Vi\u00eam ti\u1ec3u ph\u1ebf qu\u1ea3n h\u00f4 h\u1ea5p (vi\u00eam ph\u1ed5i k\u1ebd bong v\u1ea3y).<\/p>\n<p>&#8211; Vi\u00eam ph\u1ed5i t\u1ed5 ch\u1ee9c h\u00f3a t\u1eafc ngh\u1ebdn ti\u1ec3u ph\u1ebf qu\u1ea3n (BOOP).<\/p>\n<p>&#8211; Vi\u00eam ph\u1ed5i k\u1ebd kh\u00f4ng \u0111\u1eb7c hi\u1ec7u.<\/p>\n<p>&#8211; Vi\u00eam ph\u1ed5i k\u1ebd b\u1ea1ch m\u1ea1ch (H\u1ed9i ch\u1ee9ng Sjogren, b\u1ec7nh t\u1ed5 ch\u1ee9c li\u00ean k\u1ebft, h\u1ed9i ch\u1ee9ng suy gi\u1ea3m mi\u1ec5n d\u1ecbch m\u1eafc ph\u1ea3i do HIV, vi\u00eam tuy\u1ebfn gi\u00e1p Hashimoto).<\/p>\n<p>&#8211; X\u01a1 ph\u1ed5i t\u1ef1 mi\u1ec5n: b\u1ec7nh vi\u00eam ru\u1ed9t, x\u01a1 gan m\u1eadt nguy\u00ean ph\u00e1t, ban xu\u1ea5t huy\u1ebft gi\u1ea3m ti\u1ec3u c\u1ea7u t\u1ef1 ph\u00e1t, thi\u1ebfu m\u00e1u tan m\u00e1u t\u1ef1 mi\u1ec5n.<\/p>\n<h2><strong>3. \u0110i\u1ec1u tr\u1ecb<\/strong><\/h2>\n<p>Nguy\u00ean t\u1eafc chung:<\/p>\n<p>&#8211; Lo\u1ea1i b\u1ecf c\u00e1c t\u00e1c nh\u00e2n nh\u01b0 thu\u1ed1c, h\u00f3a ch\u1ea5t \u0111\u01b0\u1ee3c xem l\u00e0 c\u0103n nguy\u00ean g\u00e2y vi\u00eam ph\u1ed5i k\u1ebd.<\/p>\n<p>&#8211; \u0110i\u1ec1u tr\u1ecb c\u00e1c b\u1ec7nh l\u00fd c\u0103n nguy\u00ean c\u1ee7a vi\u00eam ph\u1ed5i k\u1ebd nh\u01b0: lupus ban \u0111\u1ecf h\u1ec7 th\u1ed1ng, x\u01a1 c\u1ee9ng b\u00ec, vi\u00eam kh\u1edbp d\u1ea1ng th\u1ea5p, vi\u00eam da c\u01a1 &#8211; vi\u00eam \u0111a c\u01a1.<\/p>\n<p>&#8211; Th\u1edf oxy khi b\u1ec7nh nh\u00e2n c\u00f3 bi\u1ec3u hi\u1ec7n suy h\u00f4 h\u1ea5p.<\/p>\n<h3><strong>3.1. Vi\u00eam ph\u1ed5i k\u1ebd kh\u00f4ng \u0111\u1eb7c hi\u1ec7u<\/strong><\/h3>\n<p>&#8211; Corticoid: kh\u1edfi \u0111\u1ea7u li\u1ec1u 1 mg\/kg\/ng\u00e0y trong 1 th\u00e1ng, sau \u0111\u00f3 gi\u1ea3m li\u1ec1u c\u00f2n 30-40 mg\/ng\u00e0y trong 2 th\u00e1ng. V\u1edbi nh\u1eefng tr\u01b0\u1eddng h\u1ee3p b\u1ec7nh n\u1eb7ng, c\u1ea7n nh\u1eadp vi\u1ec7n, c\u00f3 th\u1ec3 d\u00f9ng li\u1ec1u cao methylprednisolon 1000 mg\/ng\u00e0y x 3 ng\u00e0y, sau \u0111\u00f3 d\u00f9ng li\u1ec1u t\u01b0\u01a1ng t\u1ef1 nh\u01b0 tr\u00ean. V\u1edbi nh\u1eefng tr\u01b0\u1eddng h\u1ee3p \u0111\u00e1p \u1ee9ng, li\u1ec1u corticoid \u0111\u01b0\u1ee3c gi\u1ea3m d\u1ea7n v\u00e0 duy tr\u00ec li\u1ec1u 5-10 mg\/ng\u00e0y. T\u1ed5ng th\u1eddi gian \u0111i\u1ec1u tr\u1ecb corticoid k\u00e9o d\u00e0i \u00edt nh\u1ea5t 1 n\u0103m, li\u1ec1u corticoid gi\u1ea3m d\u1ea7n.<\/p>\n<p>&#8211; C\u00f3 th\u1ec3 d\u00f9ng m\u1ed9t s\u1ed1 thu\u1ed1c \u1ee9c ch\u1ebf mi\u1ec5n d\u1ecbch kh\u00e1c nh\u01b0: Azathioprine (kh\u1edfi li\u1ec1u 50 mg\/ng\u00e0y, sau \u0111\u00f3 t\u0103ng m\u1ed7i 25 mg\/ng\u00e0y trong 7- 14 ng\u00e0y \u0111\u1ec3 \u0111\u1ea1t li\u1ec1u 1,5-2 mg\/kg\/ng\u00e0y); cyclophosphamid (li\u1ec1u 1,5-2 mg\/kg\/ng\u00e0y. Li\u1ec1u \u0111\u01b0\u1ee3c \u0111i\u1ec1u ch\u1ec9nh \u0111\u1ec3 duy tr\u00ec s\u1ed1 l\u01b0\u1ee3ng b\u1ea1ch c\u1ea7u &gt; 4 G\/L).<\/p>\n<h3><strong>3.2. X\u01a1 ph\u1ed5i t\u1ef1 ph\u00e1t<\/strong><\/h3>\n<p>&#8211; Kh\u00f4ng d\u00f9ng c\u00e1c thu\u1ed1c corticoid v\u00e0 thu\u1ed1c \u1ee9c ch\u1ebf mi\u1ec5n d\u1ecbch do kh\u00f4ng c\u00f3 b\u1eb1ng ch\u1ee9ng cho th\u1ea5y c\u00e1c thu\u1ed1c n\u00e0y c\u00f3 hi\u1ec7u qu\u1ea3.<\/p>\n<p>&#8211; Khi c\u00f3 \u0111\u1ee3t b\u1ed9i nhi\u1ec5m: kh\u00e1ng sinh ph\u1ed5 r\u1ed9ng, th\u1edf oxy, c\u00f3 th\u1ec3 c\u00e2n nh\u1eafc th\u1edf m\u00e1y (khi c\u1ea7n) \u0111\u1ec3 duy tr\u00ec SpO<sub>2<\/sub>\u00a0&gt; 90%.<\/p>\n<p>&#8211; Ti\u00eam vaccin ph\u00f2ng c\u00fam h\u00e0ng n\u0103m v\u00e0 vaccin ph\u00f2ng ph\u1ebf c\u1ea7u m\u1ed7i 4 n\u0103m.<\/p>\n<h3><strong>3.3. Vi\u00eam ph\u1ed5i k\u1ebd t\u0103ng b\u1ea1ch c\u1ea7u \u00e1i toan<\/strong><\/h3>\n<p>&#8211; Khi kh\u00f4ng c\u00f3 suy h\u00f4 h\u1ea5p: corticoid \u0111\u01b0\u1eddng u\u1ed1ng, li\u1ec1u 40 &#8211; 60 mg\/ng\u00e0y.<\/p>\n<p>&#8211; Khi c\u00f3 suy h\u00f4 h\u1ea5p: methylprednisolon 60-125 mg m\u1ed7i 6 gi\u1edd, cho \u0111\u1ebfn khi tri\u1ec7u ch\u1ee9ng suy h\u00f4 h\u1ea5p \u0111\u01b0\u1ee3c c\u1ea3i thi\u1ec7n (th\u01b0\u1eddng 1-3 ng\u00e0y).<\/p>\n<p>&#8211; Li\u1ec1u corticoid 40-60 mg\/ng\u00e0y k\u00e9o d\u00e0i trong 2-4 tu\u1ea7n cho \u0111\u1ebfn khi h\u1ebft c\u00e1c tri\u1ec7u ch\u1ee9ng l\u00e2m s\u00e0ng v\u00e0 X-quang, sau \u0111\u00f3 gi\u1ea3m li\u1ec1u m\u1ed7i 5 mg\/tu\u1ea7n cho \u0111\u1ebfn khi h\u1ebft thu\u1ed1c.<\/p>\n<h3><strong>3.4. Vi\u00eam ph\u1ed5i t\u0103ng c\u1ea3m<\/strong><\/h3>\n<p>&#8211; Tr\u00e1nh ti\u1ebfp x\u00fac y\u1ebfu t\u1ed1 c\u0103n nguy\u00ean g\u00e2y b\u1ec7nh<\/p>\n<p>&#8211; Corticoid 40-60 mg\/ng\u00e0y trong 1-2 tu\u1ea7n. Sau \u0111\u00f3 gi\u1ea3m d\u1ea7n li\u1ec1u trong 2-4 tu\u1ea7n ti\u1ebfp theo. N\u1ebfu b\u1ec7nh t\u00e1i ph\u00e1t, c\u00f3 th\u1ec3 s\u1eed d\u1ee5ng li\u1ec7u ph\u00e1p kh\u00ed dung corticoid.<\/p>\n<h3><strong>3.5. Vi\u00eam ph\u1ed5i k\u1ebd\/Vi\u00eam kh\u1edbp d\u1ea1ng th\u1ea5p<\/strong><\/h3>\n<p>&#8211; C\u00e1c \u0111i\u1ec1u tr\u1ecb kh\u00e1c nh\u01b0 \u0111i\u1ec1u tr\u1ecb vi\u00eam kh\u1edbp d\u1ea1ng th\u1ea5p. N\u00ean d\u00f9ng corticoid ngay t\u1eeb \u0111\u1ea7u, li\u1ec1u 0,5 mg\/kg\/ng\u00e0y. Kh\u00f4ng d\u00f9ng li\u1ec1u v\u01b0\u1ee3t qu\u00e1 100 mg\/ng\u00e0y. Hi\u1ec7u qu\u1ea3 th\u01b0\u1eddng th\u1ea5y trong 1-3 tu\u1ea7n. Sau \u0111\u00f3 gi\u1ea3m d\u1ea7n li\u1ec1u corticoid.<\/p>\n<h3><strong>3.6. Vi\u00eam ph\u1ed5i k\u1ebd \u1edf b\u1ec7nh nh\u00e2n x\u01a1 c\u1ee9ng b\u00ec to\u00e0n th\u1ec3<\/strong><\/h3>\n<p>&#8211; Truy\u1ec1n t\u0129nh m\u1ea1ch cyclophosphamid (750-1000 mg\/m<sup>2<\/sup>da\/l\u1ea7n), kho\u1ea3ng c\u00e1ch 2 l\u1ea7n truy\u1ec1n: 4 tu\u1ea7n; k\u1ebft h\u1ee3p li\u1ec1u th\u1ea5p corticoid (\u2264 10 mg\/ng\u00e0y). Th\u1eddi gian \u0111i\u1ec1u tr\u1ecb: 12 th\u00e1ng.<\/p>\n<h3><strong>3.7. Vi\u00eam ph\u1ed5i k\u1ebd sau x\u1ea1 tr\u1ecb<\/strong><\/h3>\n<p>&#8211; D\u1eebng x\u1ea1 tr\u1ecb<\/p>\n<p>&#8211; Khi ch\u01b0a c\u00f3 x\u01a1 ph\u1ed5i (h\u00ecnh \u1ea3nh k\u00ednh m\u1edd l\u00e0 t\u1ed5n th\u01b0\u01a1ng n\u1ed5i b\u1eadt tr\u00ean X- quang): d\u00f9ng corticoid li\u1ec1u 1-2 mg\/kg\/ng\u00e0y.<\/p>\n<p>&#8211; Khi \u0111\u00e3 c\u00f3 x\u01a1 ph\u1ed5i: th\u1edf oxy, \u0111i\u1ec1u tr\u1ecb c\u00e1c \u0111\u1ee3t b\u1ed9i nhi\u1ec5m n\u1ebfu c\u00f3.<\/p>\n<p><strong>Ngu\u1ed3n tham kh\u1ea3o<\/strong>:<\/p>\n<ul>\n<li>H\u01b0\u1edbng d\u1eabn ch\u1ea9n \u0111o\u00e1n v\u00e0 \u0111i\u1ec1u tr\u1ecb b\u1ec7nh h\u00f4 h\u1ea5p theo B\u1ed9 Y t\u1ebf 2015.<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<div id=\"USE_CHAT_GPT_AI_ROOT\" style=\"display: none; z-index: -1; position: absolute; top: -10000px; left: -10000px; width: 1px; height: 1px; overflow: hidden; opacity: 0; pointer-events: none;\">usechatgpt init success<\/div>\n","protected":false},"excerpt":{"rendered":"<p>Vi\u00eam ph\u1ed5i k\u1ebd (Interstitial Lung Diseases) l\u00e0 t\u00ecnh tr\u1ea1ng b\u1ec7nh l\u00fd ph\u1ee9c t\u1ea1p, c\u00f3 th\u1ec3 g\u00e2y ra nhi\u1ec1u bi\u1ebfn ch\u1ee9ng nghi\u00eam tr\u1ecdng v\u00e0 \u1ea3nh h\u01b0\u1edfng \u0111\u1ebfn ch\u1ea5t l\u01b0\u1ee3ng cu\u1ed9c s\u1ed1ng c\u1ee7a ng\u01b0\u1eddi b\u1ec7nh. 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