{"id":32846,"date":"2023-05-09T12:39:11","date_gmt":"2023-05-09T05:39:11","guid":{"rendered":"http:\/\/noithathoaphat.in\/ctv\/?p=32846"},"modified":"2023-05-09T12:39:11","modified_gmt":"2023-05-09T05:39:11","slug":"xet-nghiem-egfr-trong-ung-thu-phoi-khong-te-bao-nho","status":"publish","type":"post","link":"http:\/\/noithathoaphat.in\/ctv\/index.php\/2023\/05\/09\/xet-nghiem-egfr-trong-ung-thu-phoi-khong-te-bao-nho\/","title":{"rendered":"X\u00e9t nghi\u1ec7m EGFR trong ung th\u01b0 ph\u1ed5i kh\u00f4ng t\u1ebf b\u00e0o nh\u1ecf"},"content":{"rendered":"

X\u00e9t nghi\u1ec7m EGFR l\u00e0 m\u1ed9t trong nh\u1eefng x\u00e9t nghi\u1ec7m ph\u1ed5 bi\u1ebfn \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng trong ch\u1ea9n \u0111o\u00e1n ung th\u01b0 ph\u1ed5i kh\u00f4ng t\u1ebf b\u00e0o nh\u1ecf. \u0110\u00e2y l\u00e0 m\u1ed9t lo\u1ea1i ung th\u01b0 ph\u1ed5i ph\u1ed5 bi\u1ebfn tr\u00ean to\u00e0n th\u1ebf gi\u1edbi.<\/strong><\/p>\n

1. Gi\u1edbi thi\u1ec7u<\/h2>\n

Ung th\u01b0 ph\u1ed5i kh\u00f4ng t\u1ebf b\u00e0o nh\u1ecf (non-small cell lung cancer – NSCLC) l\u00e0 m\u1ed9t lo\u1ea1i ung th\u01b0 ph\u1ed5i ph\u1ed5 bi\u1ebfn tr\u00ean to\u00e0n th\u1ebf gi\u1edbi. \u0110\u00e2y l\u00e0 lo\u1ea1i ung th\u01b0 ph\u1ed5i ph\u00e1t tri\u1ec3n t\u1eeb t\u1ebf b\u00e0o bi\u1ec3u m\u00f4 ph\u1ed5i. Ung th\u01b0 ph\u1ed5i kh\u00f4ng t\u1ebf b\u00e0o nh\u1ecf th\u01b0\u1eddng x\u1ea3y ra \u1edf nh\u1eefng ng\u01b0\u1eddi tr\u01b0\u1edfng th\u00e0nh, \u0111\u1eb7c bi\u1ec7t l\u00e0 nh\u1eefng ng\u01b0\u1eddi h\u00fat thu\u1ed1c v\u00e0 c\u00f3 ti\u1ec1n s\u1eed h\u00fat thu\u1ed1c. Ngo\u00e0i ra, c\u00e1c y\u1ebfu t\u1ed1 kh\u00e1c nh\u01b0 t\u00e1c \u0111\u1ed9ng c\u1ee7a c\u00e1c ch\u1ea5t \u0111\u1ed9c h\u1ea1i, \u00f4 nhi\u1ec5m m\u00f4i tr\u01b0\u1eddng, di truy\u1ec1n v\u00e0 tu\u1ed5i t\u00e1c c\u0169ng c\u00f3 th\u1ec3 \u0111\u00f3ng vai tr\u00f2 trong s\u1ef1 ph\u00e1t tri\u1ec3n c\u1ee7a b\u1ec7nh.<\/p>\n

EGFR (epidermal growth factor receptor) l\u00e0 m\u1ed9t lo\u1ea1i protein n\u1eb1m tr\u00ean b\u1ec1 m\u1eb7t c\u1ee7a t\u1ebf b\u00e0o ung th\u01b0 ph\u1ed5i kh\u00f4ng t\u1ebf b\u00e0o nh\u1ecf, n\u00f3 gi\u00fap t\u1ebf b\u00e0o ung th\u01b0 ph\u00e1t tri\u1ec3n v\u00e0 ph\u00e1t tri\u1ec3n m\u1ed9t c\u00e1ch kh\u00f4ng ki\u1ec3m so\u00e1t. EGFR \u0111\u01b0\u1ee3c k\u00edch ho\u1ea1t khi c\u00e1c ph\u00e2n t\u1eed ligand (nh\u01b0 EGF, TGF-\u03b1) k\u1ebft h\u1ee3p v\u1edbi n\u00f3, l\u00e0m cho EGFR t\u1ef1 k\u00edch ho\u1ea1t v\u00e0 k\u00edch ho\u1ea1t c\u00e1c t\u00edn hi\u1ec7u t\u1ebf b\u00e0o, g\u00f3p ph\u1ea7n v\u00e0o qu\u00e1 tr\u00ecnh t\u0103ng sinh v\u00e0 chuy\u1ec3n h\u00f3a t\u1ebf b\u00e0o ung th\u01b0.<\/p>\n

EGFR c\u0169ng \u0111\u01b0\u1ee3c bi\u1ebft \u0111\u1ebfn nh\u01b0 l\u00e0 m\u1ed9t trong nh\u1eefng nh\u00e2n t\u1ed1 quan tr\u1ecdng trong qu\u00e1 tr\u00ecnh kh\u00e1ng thu\u1ed1c c\u1ee7a b\u1ec7nh ung th\u01b0 ph\u1ed5i kh\u00f4ng t\u1ebf b\u00e0o nh\u1ecf. Vi\u1ec7c s\u1eed d\u1ee5ng c\u00e1c lo\u1ea1i thu\u1ed1c \u1ee9c ch\u1ebf EGFR (EGFR inhibitors) nh\u01b0 gefitinib, erlotinib, afatinib v\u00e0 osimertinib \u0111\u00e3 \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng trong \u0111i\u1ec1u tr\u1ecb ung th\u01b0 ph\u1ed5i kh\u00f4ng t\u1ebf b\u00e0o nh\u1ecf v\u00e0 \u0111\u00e3 cho th\u1ea5y hi\u1ec7u qu\u1ea3 trong m\u1ed9t s\u1ed1 tr\u01b0\u1eddng h\u1ee3p. Tuy nhi\u00ean, c\u00e1c c\u01a1 ch\u1ebf kh\u00e1ng thu\u1ed1c c\u0169ng \u0111\u01b0\u1ee3c ghi nh\u1eadn \u0111\u1ed1i v\u1edbi c\u00e1c lo\u1ea1i thu\u1ed1c n\u00e0y, v\u00e0 vi\u1ec7c nghi\u00ean c\u1ee9u v\u00e0 ph\u00e1t tri\u1ec3n c\u00e1c ph\u01b0\u01a1ng ph\u00e1p kh\u00e1c nh\u1eb1m t\u0103ng c\u01b0\u1eddng hi\u1ec7u qu\u1ea3 \u0111i\u1ec1u tr\u1ecb l\u00e0 c\u1ea7n thi\u1ebft.<\/p>\n

\"hinh-anh-phan-tu-EGFR\"
H\u00ecnh \u1ea3nh ph\u00e2n t\u1eed EGFR<\/a><\/figcaption><\/figure>\n

2. C\u00e1c l\u1ee3i \u00edch c\u1ee7a x\u00e9t nghi\u1ec7m EGFR trong ung th\u01b0 ph\u1ed5i kh\u00f4ng t\u1ebf b\u00e0o nh\u1ecf<\/h2>\n

X\u00e9t nghi\u1ec7m EGFR l\u00e0 m\u1ed9t trong nh\u1eefng c\u00f4ng c\u1ee5 quan tr\u1ecdng trong ch\u1ea9n \u0111o\u00e1n v\u00e0 \u0111i\u1ec1u tr\u1ecb ung th\u01b0 ph\u1ed5i kh\u00f4ng t\u1ebf b\u00e0o nh\u1ecf. C\u00e1c bi\u1ebfn th\u1ec3 c\u1ee7a\u00a0EGFR\u00a0\u0111\u01b0\u1ee3c t\u00ecm th\u1ea5y trong kh\u1ed1i u ung th\u01b0 ph\u1ed5i c\u00f3 th\u1ec3 gi\u00fap x\u00e1c \u0111\u1ecbnh d\u1ea1ng ung th\u01b0 ph\u1ed5i v\u00e0 \u0111\u01b0a ra k\u1ebf ho\u1ea1ch \u0111i\u1ec1u tr\u1ecb ph\u00f9 h\u1ee3p nh\u1ea5t.<\/p>\n

X\u00e9t nghi\u1ec7m EGFR l\u00e0 m\u1ed9t ph\u01b0\u01a1ng ph\u00e1p \u0111\u01a1n gi\u1ea3n v\u00e0 kh\u00f4ng x\u00e2m l\u1ea5n \u0111\u1ec3 x\u00e1c \u0111\u1ecbnh vi\u1ec7c c\u00f3 bi\u1ebfn th\u1ec3 c\u1ee7a EGFR trong t\u1ebf b\u00e0o ung th\u01b0 hay kh\u00f4ng. Vi\u1ec7c ph\u00e1t hi\u1ec7n bi\u1ebfn th\u1ec3 n\u00e0y c\u00f3 th\u1ec3 gi\u00fap b\u00e1c s\u0129 v\u00e0 b\u1ec7nh nh\u00e2n l\u1ef1a ch\u1ecdn ph\u01b0\u01a1ng ph\u00e1p \u0111i\u1ec1u tr\u1ecb ph\u00f9 h\u1ee3p, nh\u01b0 s\u1eed d\u1ee5ng c\u00e1c lo\u1ea1i thu\u1ed1c ti\u1ebfp x\u00fac v\u1edbi EGFR (EGFR inhibitors) ho\u1eb7c c\u00e1c ph\u01b0\u01a1ng ph\u00e1p \u0111i\u1ec1u tr\u1ecb kh\u00e1c.<\/p>\n

C\u00e1c nghi\u00ean c\u1ee9u \u0111\u00e3 ch\u1ee9ng minh r\u1eb1ng x\u00e9t nghi\u1ec7m EGFR l\u00e0 m\u1ed9t c\u00f4ng c\u1ee5 quan tr\u1ecdng \u0111\u1ec3 x\u00e1c \u0111\u1ecbnh d\u1ea1ng ung th\u01b0 ph\u1ed5i kh\u00f4ng t\u1ebf b\u00e0o nh\u1ecf v\u00e0 \u0111\u01b0a ra k\u1ebf ho\u1ea1ch \u0111i\u1ec1u tr\u1ecb ph\u00f9 h\u1ee3p. N\u00f3 gi\u00fap t\u0103ng \u0111\u1ed9 ch\u00ednh x\u00e1c c\u1ee7a ch\u1ea9n \u0111o\u00e1n ung th\u01b0 ph\u1ed5i v\u00e0 gi\u1ea3m thi\u1ec3u t\u1ed1i \u0111a c\u00e1c sai s\u00f3t trong qu\u00e1 tr\u00ecnh ch\u1ea9n \u0111o\u00e1n. Vi\u1ec7c \u00e1p d\u1ee5ng x\u00e9t nghi\u1ec7m EGFR trong ch\u1ea9n \u0111o\u00e1n v\u00e0 \u0111i\u1ec1u tr\u1ecb ung th\u01b0 ph\u1ed5i kh\u00f4ng t\u1ebf b\u00e0o nh\u1ecf l\u00e0 m\u1ed9t b\u01b0\u1edbc ti\u1ebfn m\u1edbi trong vi\u1ec7c hi\u1ec3u bi\u1ebft v\u00e0 qu\u1ea3n l\u00fd ung th\u01b0 ph\u1ed5i, \u0111\u1eb7c bi\u1ec7t l\u00e0 trong b\u1ed1i c\u1ea3nh c\u00e1c ph\u01b0\u01a1ng ph\u00e1p ch\u1ea9n \u0111o\u00e1n v\u00e0 \u0111i\u1ec1u tr\u1ecb ung th\u01b0 ph\u1ed5i ng\u00e0y c\u00e0ng \u0111\u01b0\u1ee3c c\u00e1 nh\u00e2n h\u00f3a v\u00e0 t\u1ed1i \u01b0u h\u00f3a. Tuy nhi\u00ean, c\u1ea7n l\u01b0u \u00fd r\u1eb1ng x\u00e9t nghi\u1ec7m EGFR c\u1ea7n \u0111\u01b0\u1ee3c k\u1ebft h\u1ee3p v\u1edbi c\u00e1c ph\u01b0\u01a1ng ph\u00e1p ch\u1ea9n \u0111o\u00e1n kh\u00e1c \u0111\u1ec3 \u0111\u01b0a ra k\u1ebft lu\u1eadn ch\u1ea9n \u0111o\u00e1n ch\u00ednh x\u00e1c v\u00e0 \u0111\u01b0a ra k\u1ebf ho\u1ea1ch \u0111i\u1ec1u tr\u1ecb ph\u00f9 h\u1ee3p.<\/p>\n

3. Nh\u1eefng \u0111i\u1ec1u c\u1ea7n l\u01b0u \u00fd khi s\u1eed d\u1ee5ng x\u00e9t nghi\u1ec7m EGFR trong ung th\u01b0 ph\u1ed5i kh\u00f4ng t\u1ebf b\u00e0o nh\u1ecf<\/h2>\n

Khi s\u1eed d\u1ee5ng x\u00e9t nghi\u1ec7m n\u00e0y, c\u1ea7n l\u01b0u \u00fd m\u1ed9t s\u1ed1 \u0111i\u1ec1u d\u01b0\u1edbi \u0111\u00e2y \u0111\u1ec3 \u0111\u1ea3m b\u1ea3o \u0111\u1ed9 ch\u00ednh x\u00e1c v\u00e0 hi\u1ec7u qu\u1ea3 c\u1ee7a ph\u01b0\u01a1ng ph\u00e1p.<\/p>\n

Th\u1ee9 nh\u1ea5t, x\u00e9t nghi\u1ec7m EGFR c\u1ea7n \u0111\u01b0\u1ee3c th\u1ef1c hi\u1ec7n trong m\u1ed9t ph\u00f2ng th\u00ed nghi\u1ec7m \u0111\u1ea7y \u0111\u1ee7 trang thi\u1ebft b\u1ecb v\u00e0 \u0111\u01b0\u1ee3c th\u1ef1c hi\u1ec7n b\u1edfi c\u00e1c chuy\u00ean gia. \u0110i\u1ec1u n\u00e0y s\u1ebd gi\u00fap \u0111\u1ea3m b\u1ea3o \u0111\u1ed9 ch\u00ednh x\u00e1c c\u1ee7a k\u1ebft qu\u1ea3 x\u00e9t nghi\u1ec7m.<\/p>\n

Th\u1ee9 hai, c\u1ea7n l\u01b0u \u00fd r\u1eb1ng vi\u1ec7c s\u1eed d\u1ee5ng x\u00e9t nghi\u1ec7m EGFR kh\u00f4ng ph\u1ea3i l\u00e0 ph\u01b0\u01a1ng ph\u00e1p ch\u1ea9n \u0111o\u00e1n ch\u00ednh x\u00e1c. X\u00e9t nghi\u1ec7m n\u00e0y ch\u1ec9 gi\u00fap ph\u00e1t hi\u1ec7n bi\u1ebfn th\u1ec3 c\u1ee7a EGFR trong t\u1ebf b\u00e0o ung th\u01b0 ph\u1ed5i, v\u00e0 k\u1ebft qu\u1ea3 x\u00e9t nghi\u1ec7m n\u00e0y c\u1ea7n \u0111\u01b0\u1ee3c k\u1ebft h\u1ee3p v\u1edbi k\u1ebft qu\u1ea3 c\u1ee7a c\u00e1c ph\u01b0\u01a1ng ph\u00e1p ch\u1ea9n \u0111o\u00e1n kh\u00e1c \u0111\u1ec3 \u0111\u01b0a ra k\u1ebft lu\u1eadn ch\u1ea9n \u0111o\u00e1n ch\u00ednh x\u00e1c.<\/p>\n

Th\u1ee9 ba, c\u1ea7n l\u01b0u \u00fd r\u1eb1ng vi\u1ec7c s\u1eed d\u1ee5ng x\u00e9t nghi\u1ec7m EGFR kh\u00f4ng ph\u1ea3i l\u00e0 ph\u01b0\u01a1ng ph\u00e1p \u0111i\u1ec1u tr\u1ecb. X\u00e9t nghi\u1ec7m n\u00e0y ch\u1ec9 gi\u00fap \u0111\u01b0a ra quy\u1ebft \u0111\u1ecbnh v\u1ec1 c\u00e1c ph\u01b0\u01a1ng ph\u00e1p \u0111i\u1ec1u tr\u1ecb ph\u00f9 h\u1ee3p. Vi\u1ec7c l\u1ef1a ch\u1ecdn ph\u01b0\u01a1ng ph\u00e1p \u0111i\u1ec1u tr\u1ecb cu\u1ed1i c\u00f9ng c\u1ea7n \u0111\u01b0\u1ee3c \u0111\u01b0a ra b\u1edfi b\u00e1c s\u0129 chuy\u00ean khoa v\u00e0 d\u1ef1a tr\u00ean c\u00e1c th\u00f4ng tin ch\u1ea9n \u0111o\u00e1n v\u00e0 l\u00e2m s\u00e0ng kh\u00e1c.<\/p>\n

Cu\u1ed1i c\u00f9ng, c\u1ea7n l\u01b0u \u00fd r\u1eb1ng vi\u1ec7c s\u1eed d\u1ee5ng x\u00e9t nghi\u1ec7m EGFR trong ch\u1ea9n \u0111o\u00e1n v\u00e0 \u0111i\u1ec1u tr\u1ecb ung th\u01b0 ph\u1ed5i kh\u00f4ng t\u1ebf b\u00e0o nh\u1ecf l\u00e0 m\u1ed9t c\u00f4ng c\u1ee5 quan tr\u1ecdng, nh\u01b0ng kh\u00f4ng \u0111\u1ee7 \u0111\u1ec3 \u0111\u01b0a ra quy\u1ebft \u0111\u1ecbnh \u0111i\u1ec1u tr\u1ecb. Vi\u1ec7c \u0111\u01b0a ra quy\u1ebft \u0111\u1ecbnh \u0111i\u1ec1u tr\u1ecb c\u1ea7n \u0111\u01b0\u1ee3c d\u1ef1a tr\u00ean m\u1ed9t k\u1ebf ho\u1ea1ch \u0111i\u1ec1u tr\u1ecb to\u00e0n di\u1ec7n, bao g\u1ed3m c\u00e1c ph\u01b0\u01a1ng ph\u00e1p \u0111i\u1ec1u tr\u1ecb kh\u00e1c nh\u01b0 ph\u1eabu thu\u1eadt, h\u00f3a tr\u1ecb, b\u1ee9c x\u1ea1 v\u00e0 c\u00e1c ph\u01b0\u01a1ng ph\u00e1p \u0111i\u1ec1u tr\u1ecb kh\u00e1c ph\u00f9 h\u1ee3p.<\/p>\n

4. K\u1ebft lu\u1eadn<\/h2>\n

Vi\u1ec7c s\u1eed d\u1ee5ng x\u00e9t nghi\u1ec7m EGFR trong ch\u1ea9n \u0111o\u00e1n v\u00e0 \u0111i\u1ec1u tr\u1ecb ung th\u01b0 ph\u1ed5i kh\u00f4ng t\u1ebf b\u00e0o nh\u1ecf l\u00e0 m\u1ed9t c\u00f4ng c\u1ee5 quan tr\u1ecdng v\u00e0 c\u1ea7n thi\u1ebft. Tuy nhi\u00ean, vi\u1ec7c \u0111\u01b0a ra quy\u1ebft \u0111\u1ecbnh \u0111i\u1ec1u tr\u1ecb cu\u1ed1i c\u00f9ng c\u1ea7n d\u1ef1a tr\u00ean m\u1ed9t k\u1ebf ho\u1ea1ch \u0111i\u1ec1u tr\u1ecb to\u00e0n di\u1ec7n v\u00e0 \u0111\u01b0\u1ee3c \u0111\u01b0a ra b\u1edfi b\u00e1c s\u0129 chuy\u00ean khoa d\u1ef1a tr\u00ean c\u00e1c th\u00f4ng tin ch\u1ea9n \u0111o\u00e1n v\u00e0 l\u00e2m s\u00e0ng kh\u00e1c.<\/p>\n","protected":false},"excerpt":{"rendered":"

X\u00e9t nghi\u1ec7m EGFR l\u00e0 m\u1ed9t trong nh\u1eefng x\u00e9t nghi\u1ec7m ph\u1ed5 bi\u1ebfn \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng trong ch\u1ea9n \u0111o\u00e1n ung th\u01b0 ph\u1ed5i kh\u00f4ng t\u1ebf b\u00e0o nh\u1ecf. \u0110\u00e2y l\u00e0 m\u1ed9t lo\u1ea1i ung th\u01b0 ph\u1ed5i ph\u1ed5 bi\u1ebfn tr\u00ean to\u00e0n th\u1ebf gi\u1edbi. 1. Gi\u1edbi thi\u1ec7u Ung th\u01b0 ph\u1ed5i kh\u00f4ng t\u1ebf b\u00e0o nh\u1ecf (non-small cell lung cancer – NSCLC) l\u00e0 m\u1ed9t […]<\/p>\n","protected":false},"author":70,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[6,33],"tags":[],"yoast_head":"\nX\u00e9t nghi\u1ec7m EGFR trong ung th\u01b0 ph\u1ed5i kh\u00f4ng t\u1ebf b\u00e0o nh\u1ecf - Vinmec<\/title>\n<meta name=\"description\" content=\"X\u00e9t nghi\u1ec7m EGFR l\u00e0 m\u1ed9t trong nh\u1eefng x\u00e9t nghi\u1ec7m ph\u1ed5 bi\u1ebfn \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng trong ch\u1ea9n \u0111o\u00e1n ung th\u01b0 ph\u1ed5i kh\u00f4ng t\u1ebf b\u00e0o nh\u1ecf\" \/>\n<meta name=\"robots\" content=\"noindex, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"X\u00e9t nghi\u1ec7m EGFR trong ung th\u01b0 ph\u1ed5i kh\u00f4ng t\u1ebf b\u00e0o nh\u1ecf - 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