{"id":3257,"date":"2023-04-14T19:37:42","date_gmt":"2023-04-14T12:37:42","guid":{"rendered":"http:\/\/noithathoaphat.in\/ctv\/?p=3257"},"modified":"2023-04-17T15:51:20","modified_gmt":"2023-04-17T08:51:20","slug":"thang-diem-trong-danh-gia-chuoi-di-truyen","status":"publish","type":"post","link":"http:\/\/noithathoaphat.in\/ctv\/index.php\/2023\/04\/14\/thang-diem-trong-danh-gia-chuoi-di-truyen\/","title":{"rendered":"Thang \u0111i\u1ec3m trong \u0111\u00e1nh gi\u00e1 chu\u1ed7i di truy\u1ec1n"},"content":{"rendered":"<p><strong>Scoring Schemes l\u00e0 b\u1ed9 thang \u0111i\u1ec3m \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng \u0111\u1ec3 t\u00ednh to\u00e1n \u0111i\u1ec3m t\u01b0\u01a1ng \u0111\u1ed3ng gi\u1eefa c\u00e1c c\u1eb7p nucleotide ho\u1eb7c amino acid trong qu\u00e1 tr\u00ecnh alignment. BLOSUM l\u00e0 ma tr\u1eadn \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng trong pairwise alignment protein, c\u00f3 \u0111\u1ed9 ph\u00e2n gi\u1ea3i kh\u00e1c nhau nh\u01b0 BLOSUM30, BLOSUM62, BLOSUM80 t\u00f9y thu\u1ed9c v\u00e0o \u0111\u1ed9 t\u01b0\u01a1ng \u0111\u1ed3ng protein. PAM l\u00e0 thang \u0111i\u1ec3m s\u1eed d\u1ee5ng trong pairwise alignment nucleotide, \u0111\u00e1nh gi\u00e1 m\u1ee9c \u0111\u1ed9 t\u01b0\u01a1ng \u0111\u1ed3ng gi\u1eefa c\u00e1c c\u1eb7p nucleotide. S\u1eed d\u1ee5ng c\u00e1c thang \u0111i\u1ec3m ph\u00f9 h\u1ee3p s\u1ebd c\u1ea3i thi\u1ec7n t\u00ednh ch\u00ednh x\u00e1c v\u00e0 hi\u1ec7u qu\u1ea3 c\u1ee7a k\u1ebft qu\u1ea3 alignment trong nghi\u00ean c\u1ee9u di truy\u1ec1n v\u00e0 sinh h\u1ecdc ph\u00e2n t\u1eed.<\/strong><\/p>\n<h4>1. T\u1ed5ng quan v\u1ec1 Scoring Schemes<\/h4>\n<p><strong>Scoring Schemes<\/strong> l\u00e0 m\u1ed9t kh\u00e1i ni\u1ec7m trong nghi\u00ean c\u1ee9u di truy\u1ec1n v\u00e0 sinh h\u1ecdc ph\u00e2n t\u1eed, \u0111\u1ec1 c\u1eadp \u0111\u1ebfn m\u1ed9t b\u1ed9 c\u00e1c thang \u0111i\u1ec3m (scoring scheme) \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng \u0111\u1ec3 t\u00ednh to\u00e1n \u0111i\u1ec3m t\u01b0\u01a1ng \u0111\u1ed3ng gi\u1eefa c\u00e1c c\u1eb7p nucleotide ho\u1eb7c amino acid trong qu\u00e1 tr\u00ecnh alignment. Thang \u0111i\u1ec3m th\u01b0\u1eddng bao g\u1ed3m hai th\u00e0nh ph\u1ea7n ch\u00ednh l\u00e0 \u0111i\u1ec3m kh\u1edbp (match score) v\u00e0 \u0111i\u1ec3m kh\u00f4ng kh\u1edbp (mismatch penalty), \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng \u0111\u1ec3 \u0111\u00e1nh gi\u00e1 m\u1ee9c \u0111\u1ed9 t\u01b0\u01a1ng \u0111\u1ed3ng gi\u1eefa c\u00e1c c\u1eb7p nucleotide ho\u1eb7c amino acid trong c\u00e1c chu\u1ed7i d\u1eef li\u1ec7u.<\/p>\n<p>C\u00e1c thang \u0111i\u1ec3m kh\u00e1c nhau c\u00f3 th\u1ec3 \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng t\u00f9y thu\u1ed9c v\u00e0o m\u1ee5c \u0111\u00edch c\u1ee7a nghi\u00ean c\u1ee9u v\u00e0 \u0111\u1eb7c t\u00ednh c\u1ee7a d\u1eef li\u1ec7u. V\u00ed d\u1ee5, thang \u0111i\u1ec3m BLOSUM \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng trong pairwise alignment protein, trong khi \u0111\u00f3 thang \u0111i\u1ec3m PAM \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng trong pairwise alignment nucleotide. C\u00e1c thang \u0111i\u1ec3m ph\u00f9 h\u1ee3p s\u1ebd gi\u00fap c\u1ea3i thi\u1ec7n t\u00ednh ch\u00ednh x\u00e1c v\u00e0 hi\u1ec7u qu\u1ea3 c\u1ee7a k\u1ebft qu\u1ea3 alignment v\u00e0 \u0111\u00f3ng vai tr\u00f2 quan tr\u1ecdng trong nghi\u00ean c\u1ee9u di truy\u1ec1n v\u00e0 sinh h\u1ecdc ph\u00e2n t\u1eed.<\/p>\n<h4>2. Thang \u0111i\u1ec3m BLOSUM<\/h4>\n<p><strong>BLOSUM (Blocks Substitution Matrix)<\/strong> \u0111\u01b0\u1ee3c d\u00f9ng \u0111\u1ec3 \u0111\u00e1nh gi\u00e1 m\u1ee9c \u0111\u1ed9 t\u01b0\u01a1ng \u0111\u1ed3ng gi\u1eefa c\u00e1c c\u1eb7p amino acid trong qu\u00e1 tr\u00ecnh alignment. K\u1ebft qu\u1ea3 thu \u0111\u01b0\u1ee3c t\u1eeb vi\u1ec7c s\u1eed d\u1ee5ng BLOSUM l\u00e0 m\u1ed9t ma tr\u1eadn thay th\u1ebf, cho bi\u1ebft \u0111i\u1ec3m t\u01b0\u01a1ng \u1ee9ng c\u1ee7a m\u1ed7i c\u1eb7p amino acid trong qu\u00e1 tr\u00ecnh alignment. C\u00e1c ma tr\u1eadn BLOSUM kh\u00e1c nhau (v\u00ed d\u1ee5: BLOSUM30, BLOSUM62, BLOSUM80) c\u00f3 \u0111\u1ed9 ph\u00e2n gi\u1ea3i kh\u00e1c nhau v\u00e0 ph\u00f9 h\u1ee3p v\u1edbi c\u00e1c m\u1ee5c \u0111\u00edch alignment kh\u00e1c nhau.<\/p>\n<ul>\n<li><strong>BLOSUM30<\/strong>: Thang \u0111i\u1ec3m c\u00f3 \u0111\u1ed9 ph\u00e2n gi\u1ea3i th\u1ea5p h\u01a1n, ph\u00f9 h\u1ee3p cho vi\u1ec7c alignment c\u00e1c protein c\u00f3 \u0111\u1ed9 t\u01b0\u01a1ng \u0111\u1ed3ng th\u1ea5p. BLOSUM30 \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng trong c\u00e1c nghi\u00ean c\u1ee9u so s\u00e1nh gi\u1eefa c\u00e1c protein c\u00f3 m\u1ee9c \u0111\u1ed9 t\u01b0\u01a1ng \u0111\u1ed3ng th\u1ea5p ho\u1eb7c trong vi\u1ec7c t\u00ecm ki\u1ebfm c\u00e1c \u0111\u1ecbnh d\u1ea1ng protein m\u1edbi.<\/li>\n<li><a href=\"https:\/\/www.labxchange.org\/library\/items\/lb:LabXchange:24d0ec21:lx_image:1\"><strong>BLOSUM62<\/strong><\/a>: Thang \u0111i\u1ec3m c\u00f3 \u0111\u1ed9 ph\u00e2n gi\u1ea3i trung b\u00ecnh, ph\u00f9 h\u1ee3p cho vi\u1ec7c alignment c\u00e1c protein c\u00f3 \u0111\u1ed9 t\u01b0\u01a1ng \u0111\u1ed3ng trung b\u00ecnh. BLOSUM62 l\u00e0 thang \u0111i\u1ec3m ph\u1ed5 bi\u1ebfn nh\u1ea5t v\u00e0 \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng r\u1ed9ng r\u00e3i trong c\u00e1c c\u00f4ng c\u1ee5 alignment protein.<\/li>\n<li><strong>BLOSUM80<\/strong>: Thang \u0111i\u1ec3m c\u00f3 \u0111\u1ed9 ph\u00e2n gi\u1ea3i cao, ph\u00f9 h\u1ee3p cho vi\u1ec7c alignment c\u00e1c protein c\u00f3 \u0111\u1ed9 t\u01b0\u01a1ng \u0111\u1ed3ng cao. BLOSUM80 \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng trong c\u00e1c nghi\u00ean c\u1ee9u so s\u00e1nh gi\u1eefa c\u00e1c protein c\u00f3 m\u1ee9c \u0111\u1ed9 t\u01b0\u01a1ng \u0111\u1ed3ng cao.<\/li>\n<\/ul>\n<figure id=\"attachment_3262\" aria-describedby=\"caption-attachment-3262\" style=\"width: 1726px\" class=\"wp-caption alignnone\"><img decoding=\"async\" loading=\"lazy\" class=\"size-full wp-image-3262\" src=\"http:\/\/noithathoaphat.in\/ctv\/wp-content\/uploads\/2023\/04\/BLOSUM.png\" alt=\"Thang \u0111i\u1ec3m BLOSUM62\" width=\"1726\" height=\"1190\" srcset=\"http:\/\/noithathoaphat.in\/ctv\/wp-content\/uploads\/2023\/04\/BLOSUM.png 1726w, http:\/\/noithathoaphat.in\/ctv\/wp-content\/uploads\/2023\/04\/BLOSUM-300x207.png 300w, http:\/\/noithathoaphat.in\/ctv\/wp-content\/uploads\/2023\/04\/BLOSUM-1024x706.png 1024w, http:\/\/noithathoaphat.in\/ctv\/wp-content\/uploads\/2023\/04\/BLOSUM-768x530.png 768w, http:\/\/noithathoaphat.in\/ctv\/wp-content\/uploads\/2023\/04\/BLOSUM-1536x1059.png 1536w\" sizes=\"(max-width: 1726px) 100vw, 1726px\" \/><figcaption id=\"caption-attachment-3262\" class=\"wp-caption-text\">Thang \u0111i\u1ec3m BLOSUM62<\/figcaption><\/figure>\n<p>Khi s\u1eed d\u1ee5ng BLOSUM trong qu\u00e1 tr\u00ecnh pairwise alignment protein, m\u1ed7i c\u1eb7p amino acid trong hai chu\u1ed7i protein s\u1ebd \u0111\u01b0\u1ee3c so s\u00e1nh v\u1edbi nhau v\u00e0 \u0111\u00e1nh gi\u00e1 b\u1eb1ng \u0111i\u1ec3m t\u01b0\u01a1ng \u1ee9ng trong ma tr\u1eadn thay th\u1ebf BLOSUM. C\u00e1c amino acid kh\u1edbp s\u1ebd \u0111\u01b0\u1ee3c ghi nh\u1eadn v\u1edbi \u0111i\u1ec3m t\u01b0\u01a1ng \u1ee9ng trong ma tr\u1eadn thay th\u1ebf, trong khi c\u00e1c amino acid kh\u00f4ng kh\u1edbp s\u1ebd b\u1ecb tr\u1eeb \u0111i\u1ec3m. \u0110i\u1ec3m alignment cu\u1ed1i c\u00f9ng s\u1ebd \u0111\u01b0\u1ee3c t\u00ednh d\u1ef1a tr\u00ean t\u1ed5ng \u0111i\u1ec3m c\u1ee7a c\u00e1c c\u1eb7p amino acid trong qu\u00e1 tr\u00ecnh alignment.<\/p>\n<p>K\u1ebft qu\u1ea3 thu \u0111\u01b0\u1ee3c t\u1eeb vi\u1ec7c s\u1eed d\u1ee5ng BLOSUM l\u00e0 m\u1ed9t alignment protein ch\u00ednh x\u00e1c h\u01a1n v\u00e0 hi\u1ec7u qu\u1ea3 h\u01a1n, gi\u00fap cung c\u1ea5p th\u00f4ng tin h\u1eefu \u00edch cho nghi\u00ean c\u1ee9u v\u1ec1 c\u1ea5u tr\u00fac v\u00e0 ch\u1ee9c n\u0103ng c\u1ee7a protein. BLOSUM l\u00e0 m\u1ed9t trong nh\u1eefng thang \u0111i\u1ec3m ph\u1ed5 bi\u1ebfn nh\u1ea5t \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng trong qu\u00e1 tr\u00ecnh pairwise alignment protein.<\/p>\n<h4>3. Thang \u0111i\u1ec3m PAM<\/h4>\n<p><strong>PAM (Point Accepted Mutation)<\/strong> l\u00e0 m\u1ed9t thang \u0111i\u1ec3m (scoring scheme) \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng trong pairwise alignment nucleotide, \u0111\u1ec3 \u0111\u00e1nh gi\u00e1 m\u1ee9c \u0111\u1ed9 t\u01b0\u01a1ng \u0111\u1ed3ng gi\u1eefa c\u00e1c c\u1eb7p nucleotide trong qu\u00e1 tr\u00ecnh alignment. PAM \u0111\u01b0\u1ee3c t\u00ednh to\u00e1n d\u1ef1a tr\u00ean c\u00e1c m\u00f4 h\u00ecnh ti\u1ebfn h\u00f3a nucleotide v\u00e0 c\u00f3 \u0111\u1ed9 ph\u00e2n gi\u1ea3i kh\u00e1c nhau (v\u00ed d\u1ee5: PAM30, PAM70, PAM250). \u00dd ngh\u0129a c\u1ee7a c\u00e1c thang \u0111i\u1ec3m PAM l\u00e0:<\/p>\n<ul>\n<li><strong>PAM30:<\/strong> Thang \u0111i\u1ec3m c\u00f3 \u0111\u1ed9 ph\u00e2n gi\u1ea3i th\u1ea5p h\u01a1n, ph\u00f9 h\u1ee3p cho vi\u1ec7c alignment c\u00e1c chu\u1ed7i nucleotide c\u00f3 \u0111\u1ed9 t\u01b0\u01a1ng \u0111\u1ed3ng th\u1ea5p. PAM30 \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng trong c\u00e1c nghi\u00ean c\u1ee9u so s\u00e1nh gi\u1eefa c\u00e1c chu\u1ed7i nucleotide c\u00f3 m\u1ee9c \u0111\u1ed9 t\u01b0\u01a1ng \u0111\u1ed3ng th\u1ea5p ho\u1eb7c trong vi\u1ec7c t\u00ecm ki\u1ebfm c\u00e1c chu\u1ed7i nucleotide m\u1edbi.<\/li>\n<li><strong>PAM70:<\/strong> Thang \u0111i\u1ec3m c\u00f3 \u0111\u1ed9 ph\u00e2n gi\u1ea3i trung b\u00ecnh, ph\u00f9 h\u1ee3p cho vi\u1ec7c alignment c\u00e1c chu\u1ed7i nucleotide c\u00f3 \u0111\u1ed9 t\u01b0\u01a1ng \u0111\u1ed3ng trung b\u00ecnh. PAM70 l\u00e0 thang \u0111i\u1ec3m ph\u1ed5 bi\u1ebfn nh\u1ea5t v\u00e0 \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng r\u1ed9ng r\u00e3i trong c\u00e1c c\u00f4ng c\u1ee5 alignment nucleotide.<\/li>\n<li><strong>PAM250:<\/strong> Thang \u0111i\u1ec3m c\u00f3 \u0111\u1ed9 ph\u00e2n gi\u1ea3i cao, ph\u00f9 h\u1ee3p cho vi\u1ec7c alignment c\u00e1c chu\u1ed7i nucleotide c\u00f3 \u0111\u1ed9 t\u01b0\u01a1ng \u0111\u1ed3ng cao. PAM250 \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng trong c\u00e1c nghi\u00ean c\u1ee9u so s\u00e1nh gi\u1eefa c\u00e1c chu\u1ed7i nucleotide c\u00f3 m\u1ee9c \u0111\u1ed9 t\u01b0\u01a1ng \u0111\u1ed3ng cao.<\/li>\n<\/ul>\n<figure id=\"attachment_3265\" aria-describedby=\"caption-attachment-3265\" style=\"width: 813px\" class=\"wp-caption alignnone\"><img decoding=\"async\" loading=\"lazy\" class=\"size-full wp-image-3265\" src=\"http:\/\/noithathoaphat.in\/ctv\/wp-content\/uploads\/2023\/04\/PAM-250.png\" alt=\"Thang \u0111i\u1ec3m PAM250\" width=\"813\" height=\"525\" srcset=\"http:\/\/noithathoaphat.in\/ctv\/wp-content\/uploads\/2023\/04\/PAM-250.png 813w, http:\/\/noithathoaphat.in\/ctv\/wp-content\/uploads\/2023\/04\/PAM-250-300x194.png 300w, http:\/\/noithathoaphat.in\/ctv\/wp-content\/uploads\/2023\/04\/PAM-250-768x496.png 768w\" sizes=\"(max-width: 813px) 100vw, 813px\" \/><figcaption id=\"caption-attachment-3265\" class=\"wp-caption-text\">Thang \u0111i\u1ec3m PAM250<\/figcaption><\/figure>\n<h4>4. C\u00e1c thang \u0111i\u1ec3m kh\u00e1c<\/h4>\n<p>Ngo\u00e0i BLOSUM v\u00e0 PAM, c\u00f2n c\u00f3 m\u1ed9t s\u1ed1 b\u1ed9 thang \u0111i\u1ec3m kh\u00e1c \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng trong pairwise alignment nh\u01b0ng \u00edt ph\u1ed5 bi\u1ebfn h\u01a1n. V\u00ed d\u1ee5 nh\u01b0 thang \u0111i\u1ec3m VTML (Variable Time-delay Multivariate Linear regression), \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng cho vi\u1ec7c align c\u00e1c h\u1ecd protein c\u00f3 s\u1ef1 kh\u00e1c bi\u1ec7t trong v\u00f9ng gi\u1eefa c\u00e1c domain. Thang \u0111i\u1ec3m GONNET c\u0169ng \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng trong protein alignment, v\u1edbi \u0111\u1ed9 ph\u00e2n gi\u1ea3i cao h\u01a1n so v\u1edbi BLOSUM v\u00e0 PAM. Tuy nhi\u00ean, GONNET c\u00f3 k\u00edch th\u01b0\u1edbc ma tr\u1eadn l\u1edbn h\u01a1n, do \u0111\u00f3 c\u1ea7n nhi\u1ec1u t\u00e0i nguy\u00ean t\u00ednh to\u00e1n h\u01a1n. C\u00e1c b\u1ed9 thang \u0111i\u1ec3m kh\u00e1c nh\u01b0 JTT v\u00e0 WAG \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng cho vi\u1ec7c align c\u00e1c sequence protein d\u00e0i v\u00e0 c\u00f3 s\u1ef1 \u0111a d\u1ea1ng cao. T\u00f9y thu\u1ed9c v\u00e0o m\u1ee5c \u0111\u00edch c\u1ee7a alignment v\u00e0 \u0111\u1eb7c \u0111i\u1ec3m c\u1ee7a c\u00e1c chu\u1ed7i c\u1ea7n ph\u00e2n t\u00edch, ng\u01b0\u1eddi s\u1eed d\u1ee5ng c\u00f3 th\u1ec3 l\u1ef1a ch\u1ecdn b\u1ed9 thang \u0111i\u1ec3m ph\u00f9 h\u1ee3p \u0111\u1ec3 \u0111\u1ea1t \u0111\u01b0\u1ee3c k\u1ebft qu\u1ea3 alignment ch\u00ednh x\u00e1c v\u00e0 hi\u1ec7u qu\u1ea3 nh\u1ea5t.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Scoring Schemes l\u00e0 b\u1ed9 thang \u0111i\u1ec3m \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng \u0111\u1ec3 t\u00ednh to\u00e1n \u0111i\u1ec3m t\u01b0\u01a1ng \u0111\u1ed3ng gi\u1eefa c\u00e1c c\u1eb7p nucleotide ho\u1eb7c amino acid trong qu\u00e1 tr\u00ecnh alignment. BLOSUM l\u00e0 ma tr\u1eadn \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng trong pairwise alignment protein, c\u00f3 \u0111\u1ed9 ph\u00e2n gi\u1ea3i kh\u00e1c nhau nh\u01b0 BLOSUM30, BLOSUM62, BLOSUM80 t\u00f9y thu\u1ed9c v\u00e0o \u0111\u1ed9 t\u01b0\u01a1ng \u0111\u1ed3ng protein. PAM [&hellip;]<\/p>\n","protected":false},"author":13,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[33,14],"tags":[3],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v20.4 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Thang \u0111i\u1ec3m trong \u0111\u00e1nh gi\u00e1 chu\u1ed7i di truy\u1ec1n - Vinmec<\/title>\n<meta name=\"description\" content=\"C\u00e1c thang \u0111i\u1ec3m BLOSUM v\u00e0 PAM \u0111\u01b0\u1ee3c d\u00f9ng \u0111\u1ec3 t\u00ednh to\u00e1n \u0111i\u1ec3m t\u01b0\u01a1ng \u0111\u1ed3ng gi\u1eefa c\u00e1c c\u1eb7p nucleotide ho\u1eb7c amino acid trong qu\u00e1 tr\u00ecnh alignment.\" \/>\n<meta name=\"robots\" content=\"noindex, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Thang \u0111i\u1ec3m trong \u0111\u00e1nh gi\u00e1 chu\u1ed7i di truy\u1ec1n - Vinmec\" \/>\n<meta property=\"og:description\" content=\"C\u00e1c thang \u0111i\u1ec3m BLOSUM v\u00e0 PAM \u0111\u01b0\u1ee3c d\u00f9ng \u0111\u1ec3 t\u00ednh to\u00e1n \u0111i\u1ec3m t\u01b0\u01a1ng \u0111\u1ed3ng gi\u1eefa c\u00e1c c\u1eb7p nucleotide ho\u1eb7c amino acid trong qu\u00e1 tr\u00ecnh alignment.\" \/>\n<meta property=\"og:url\" content=\"http:\/\/noithathoaphat.in\/ctv\/index.php\/2023\/04\/14\/thang-diem-trong-danh-gia-chuoi-di-truyen\/\" \/>\n<meta property=\"og:site_name\" content=\"Vinmec\" \/>\n<meta property=\"article:published_time\" content=\"2023-04-14T12:37:42+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2023-04-17T08:51:20+00:00\" \/>\n<meta property=\"og:image\" content=\"http:\/\/noithathoaphat.in\/ctv\/wp-content\/uploads\/2023\/04\/BLOSUM.png\" \/>\n<meta name=\"author\" content=\"Son Hoang\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Son Hoang\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"5 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"http:\/\/noithathoaphat.in\/ctv\/index.php\/2023\/04\/14\/thang-diem-trong-danh-gia-chuoi-di-truyen\/\",\"url\":\"http:\/\/noithathoaphat.in\/ctv\/index.php\/2023\/04\/14\/thang-diem-trong-danh-gia-chuoi-di-truyen\/\",\"name\":\"Thang \u0111i\u1ec3m trong \u0111\u00e1nh gi\u00e1 chu\u1ed7i di truy\u1ec1n - 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