{"id":32291,"date":"2023-06-22T15:05:09","date_gmt":"2023-06-22T08:05:09","guid":{"rendered":"http:\/\/noithathoaphat.in\/ctv\/?p=32291"},"modified":"2023-06-22T15:05:09","modified_gmt":"2023-06-22T08:05:09","slug":"reproxalap-ung-cu-vien-tiem-nang-cho-benh-kho-mat","status":"publish","type":"post","link":"http:\/\/noithathoaphat.in\/ctv\/index.php\/2023\/06\/22\/reproxalap-ung-cu-vien-tiem-nang-cho-benh-kho-mat\/","title":{"rendered":"Reproxalap: \u1ee9ng c\u1eed vi\u00ean ti\u1ec1m n\u0103ng cho b\u1ec7nh kh\u00f4 m\u1eaft"},"content":{"rendered":"<p><strong>Reproxalap \u0111\u01b0\u1ee3c nghi\u00ean c\u1ee9u v\u00e0 ph\u00e1t tri\u1ec3n b\u1edfi c\u00f4ng ty c\u00f4ng ngh\u1ec7 sinh h\u1ecdc Aldeyra. C\u00e1c nghi\u00ean c\u1ee9u \u0111\u00e3 cho th\u1ea5y r\u1eb1ng Reproxalap c\u00f3 th\u1ec3 gi\u00fap ng\u0103n ch\u1eb7n s\u1ef1 ph\u00e1t tri\u1ec3n c\u1ee7a b\u1ec7nh v\u00e0 t\u0103ng c\u01b0\u1eddng c\u1ea3i thi\u1ec7n tri\u1ec7u ch\u1ee9ng c\u1ee7a b\u1ec7nh kh\u00f4 m\u1eaft.\u00a0<\/strong><\/p>\n<h2><b>1. C\u00e1c th\u00f4ng tin v\u1ec1 b\u1ec7nh l\u00fd kh\u00f4 m\u1eaft<\/b><span style=\"font-weight: 400;\">\u00a0<\/span><\/h2>\n<h3><span style=\"font-weight: 400;\">1.1 C\u1ea5u t\u1ea1o v\u00e0 ho\u1ea1t \u0111\u1ed9ng c\u1ee7a n\u01b0\u1edbc m\u1eaft\u00a0<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">\u0110\u00f4i m\u1eaft c\u1ee7a con ng\u01b0\u1eddi c\u1ea7n \u0111\u01b0\u1ee3c gi\u1eef \u1ea9m \u0111\u1ec3 c\u00f3 th\u1ec3 ho\u1ea1t \u0111\u1ed9ng t\u1ed1t v\u00e0 c\u1ea3m th\u1ea5y tho\u1ea3i m\u00e1i. N\u01b0\u1edbc m\u1eaft l\u00e0 m\u1ed9t ch\u1ea5t l\u1ecfng \u0111\u01b0\u1ee3c t\u1ea1o ra b\u1edfi c\u00e1c tuy\u1ebfn l\u1ec7 \u1edf g\u00f3c n\u1ed9i b\u00ean c\u1ee7a m\u1eaft v\u00e0 \u0111\u01b0\u1ee3c l\u01b0u th\u00f4ng tr\u00ean b\u1ec1 m\u1eb7t m\u1eaft b\u1eb1ng c\u00e1ch nh\u1ea5p nh\u00e1y. N\u1ebfu m\u1eaft kh\u00f4ng s\u1ea3n xu\u1ea5t \u0111\u1ee7 n\u01b0\u1edbc m\u1eaft ho\u1eb7c s\u1ea3n xu\u1ea5t ra m\u1ed9t lo\u1ea1i n\u01b0\u1edbc m\u1eaft kh\u00f4ng \u0111\u00fang, m\u00e0ng n\u01b0\u1edbc m\u1eaft b\u1ecb thi\u1ebfu ho\u1eb7c kh\u00f4ng \u0111\u1ee7 \u0111\u1ec3 b\u1ea3o v\u1ec7 m\u1eaft. Khi \u0111\u00f3, s\u1ebd x\u1ea3y ra t\u00ecnh tr\u1ea1ng kh\u00f4 m\u1eaft, c\u00f3 th\u1ec3 g\u00e2y ra c\u1ea3m gi\u00e1c kh\u00f3 ch\u1ecbu, ng\u1ee9a, \u0111au r\u00e1t, v\u00e0 \u1ea3nh h\u01b0\u1edfng t\u1edbi ch\u1ee9c n\u0103ng c\u1ee7a m\u1eaft. Do \u0111\u00f3, vi\u1ec7c gi\u1eef cho m\u1eaft lu\u00f4n \u0111\u1ee7 \u1ea9m l\u00e0 r\u1ea5t quan tr\u1ecdng \u0111\u1ec3 duy tr\u00ec s\u1ee9c kh\u1ecfe v\u00e0 ch\u1ee9c n\u0103ng c\u1ee7a m\u1eaft.<\/span><\/p>\n<figure id=\"attachment_32325\" aria-describedby=\"caption-attachment-32325\" style=\"width: 300px\" class=\"wp-caption aligncenter\"><img decoding=\"async\" loading=\"lazy\" class=\"size-medium wp-image-32325\" src=\"http:\/\/noithathoaphat.in\/ctv\/wp-content\/uploads\/2023\/05\/Mang-phim-nuoc-mat-300x165.png\" alt=\"M\u00e0ng phim n\u01b0\u1edbc m\u1eaft\" width=\"300\" height=\"165\" srcset=\"http:\/\/noithathoaphat.in\/ctv\/wp-content\/uploads\/2023\/05\/Mang-phim-nuoc-mat-300x165.png 300w, http:\/\/noithathoaphat.in\/ctv\/wp-content\/uploads\/2023\/05\/Mang-phim-nuoc-mat-768x422.png 768w, http:\/\/noithathoaphat.in\/ctv\/wp-content\/uploads\/2023\/05\/Mang-phim-nuoc-mat.png 869w\" sizes=\"(max-width: 300px) 100vw, 300px\" \/><figcaption id=\"caption-attachment-32325\" class=\"wp-caption-text\">M\u00e0ng phim n\u01b0\u1edbc m\u1eaft<\/figcaption><\/figure>\n<p><span style=\"font-weight: 400;\">Khi ch\u1edbp m\u1eaft, m<\/span><span style=\"font-weight: 400;\">\u00e0ng phim n\u01b0\u1edbc m\u1eaft lan tr\u00ean m\u1eaft gi\u00fap gi\u1eef cho b\u1ec1 m\u1eb7t c\u1ee7a m\u1eaft m\u1ecbn m\u00e0ng v\u00e0 r\u00f5 r\u00e0ng. Phim n\u01b0\u1edbc m\u1eaft l\u00e0 m\u1ed9t l\u1edbp m\u1ecfng c\u1ee7a ch\u1ea5t l\u1ecfng bao ph\u1ee7 b\u1ec1 m\u1eb7t m\u1eaft gi\u1eefa nh\u00e3n c\u1ea7u v\u00e0 mi m\u1eaft, bao g\u1ed3m n\u01b0\u1edbc m\u1eaft, ch\u1ea5t nh\u1ea7y v\u00e0 ch\u1ea5t b\u00e9o. Phim n\u01b0\u1edbc m\u1eaft gi\u1eef cho m\u1eaft \u1ea9m v\u00e0 m\u1ecbn m\u00e0ng b\u1ea3o v\u1ec7 m\u1eaft kh\u1ecfi s\u1ef1 c\u1ecd x\u00e1t v\u00e0 l\u00e2y nhi\u1ec5m, cung c\u1ea5p d\u01b0\u1ee1ng ch\u1ea5t cho c\u00e1c t\u1ebf b\u00e0o tr\u00ean b\u1ec1 m\u1eb7t m\u1eaft v\u00e0 gi\u00fap duy tr\u00ec th\u1ecb l\u1ef1c.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Phim n\u01b0\u1edbc m\u1eaft \u0111\u01b0\u1ee3c l\u00e0m b\u1eb1ng ba l\u1edbp:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">L\u1edbp nh\u1eddn\u00a0<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">L\u1edbp n\u01b0\u1edbc\u00a0<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">L\u1edbp nh\u1ea7y\u00a0<\/span><\/li>\n<\/ul>\n<p><span style=\"font-weight: 400;\">M\u1ed7i l\u1edbp c\u1ee7a phim n\u01b0\u1edbc m\u1eaft \u0111\u1ec1u \u0111\u00f3ng vai tr\u00f2 quan tr\u1ecdng: (1) L\u1edbp d\u1ea7u l\u00e0 b\u00ean ngo\u00e0i c\u1ee7a m\u00e0ng n\u01b0\u1edbc m\u1eaft. N\u00f3 l\u00e0m cho b\u1ec1 m\u1eb7t n\u01b0\u1edbc m\u1eaft m\u1ecbn m\u00e0ng v\u00e0 gi\u1eef cho n\u01b0\u1edbc m\u1eaft kh\u00f4ng b\u1ecb kh\u00f4 qu\u00e1 nhanh. L\u1edbp n\u00e0y \u0111\u01b0\u1ee3c t\u1ea1o ra trong c\u00e1c tuy\u1ebfn meibomian c\u1ee7a m\u1eaft.(2) L\u1edbp n\u01b0\u1edbc m\u1eaft l\u00e0 l\u1edbp gi\u1eefa c\u1ee7a m\u00e0ng n\u01b0\u1edbc m\u1eaft. L\u1edbp n\u00e0y \u0111\u01b0\u1ee3c h\u00ecnh th\u00e0nh t\u1eeb c\u00e1c tuy\u1ebfn l\u1ec7 trong m\u00ed m\u1eaft v\u00e0 gi\u00fap l\u00e0m s\u1ea1ch m\u1eaft, r\u1eeda s\u1ea1ch c\u00e1c h\u1ea1t kh\u00f4ng thu\u1ed9c v\u1ec1 m\u1eaft.(3) L\u1edbp ch\u1ea5t nh\u1ea7y l\u00e0 l\u1edbp b\u00ean trong c\u1ee7a m\u00e0ng n\u01b0\u1edbc m\u1eaft, do \u0111\u00f3 gi\u00fap tr\u1ea3i l\u1edbp n\u01b0\u1edbc tr\u00ean b\u1ec1 m\u1eb7t m\u1eaft, gi\u1eef \u1ea9m. N\u1ebfu kh\u00f4ng c\u00f3 ch\u1ea5t nh\u1ea7y, n\u01b0\u1edbc m\u1eaft s\u1ebd kh\u00f4ng d\u00ednh v\u00e0o m\u1eaft. Ch\u1ea5t nh\u1ea7y \u0111\u01b0\u1ee3c t\u1ea1o ra trong k\u1ebft m\u1ea1c v\u00e0 l\u00e0 l\u1edbp m\u00f4 trong su\u1ed1t bao ph\u1ee7 l\u00f2ng tr\u1eafng m\u1eaft v\u00e0 b\u00ean trong m\u00ed m\u1eaft<\/span><\/p>\n<h3><span style=\"font-weight: 400;\">1.2 B\u1ec7nh l\u00fd kh\u00f4 m\u1eaft\u00a0<\/span><\/h3>\n<p><span style=\"font-weight: 400;\"><a href=\"https:\/\/www.vinmec.com\/vi\/benh\/kho-mat-3081\/\">B\u1ec7nh l\u00fd kh\u00f4 m\u1eaft<\/a> l\u00e0 m\u1ed9t t\u00ecnh tr\u1ea1ng m\u1eaft th\u01b0\u1eddng g\u1eb7p khi m\u1eaft kh\u00f4ng s\u1ea3n xu\u1ea5t \u0111\u1ee7 n\u01b0\u1edbc m\u1eaft ho\u1eb7c n\u01b0\u1edbc m\u1eaft kh\u00f4ng \u0111\u1ee7 ch\u1ea5t l\u01b0\u1ee3ng \u0111\u1ec3 b\u1ea3o v\u1ec7 v\u00e0 gi\u1eef \u1ea9m cho m\u1eaft. \u0110\u00e2y l\u00e0 m\u1ed9t v\u1ea5n \u0111\u1ec1 kh\u00e1 ph\u1ed5 bi\u1ebfn, \u0111\u1eb7c bi\u1ec7t \u1edf nh\u1eefng ng\u01b0\u1eddi tr\u00ean 50 tu\u1ed5i v\u00e0 nh\u1eefng ng\u01b0\u1eddi s\u1eed d\u1ee5ng m\u00e1y t\u00ednh nhi\u1ec1u.<\/span><\/p>\n<figure id=\"attachment_32326\" aria-describedby=\"caption-attachment-32326\" style=\"width: 300px\" class=\"wp-caption aligncenter\"><img decoding=\"async\" loading=\"lazy\" class=\"size-medium wp-image-32326\" src=\"http:\/\/noithathoaphat.in\/ctv\/wp-content\/uploads\/2023\/05\/Benh-ly-kho-mat-300x222.webp\" alt=\"B\u1ec7nh l\u00fd kh\u00f4 m\u1eaft\" width=\"300\" height=\"222\" srcset=\"http:\/\/noithathoaphat.in\/ctv\/wp-content\/uploads\/2023\/05\/Benh-ly-kho-mat-300x222.webp 300w, http:\/\/noithathoaphat.in\/ctv\/wp-content\/uploads\/2023\/05\/Benh-ly-kho-mat.webp 632w\" sizes=\"(max-width: 300px) 100vw, 300px\" \/><figcaption id=\"caption-attachment-32326\" class=\"wp-caption-text\">B\u1ec7nh l\u00fd kh\u00f4 m\u1eaft<\/figcaption><\/figure>\n<p><span style=\"font-weight: 400;\">C\u00e1c tri\u1ec7u ch\u1ee9ng c\u1ee7a b\u1ec7nh l\u00fd kh\u00f4 m\u1eaft bao g\u1ed3m c\u1ea3m gi\u00e1c kh\u00f4, \u0111\u1ecf v\u00e0 ng\u1ee9a trong m\u1eaft, c\u1ea3m gi\u00e1c \u0111au r\u00e1t ho\u1eb7c nh\u1ee9c m\u1eaft, m\u1edd m\u1eaft v\u00e0 kh\u00f3 nh\u00ecn ban \u0111\u00eam. Nh\u1eefng tri\u1ec7u ch\u1ee9ng n\u00e0y c\u00f3 th\u1ec3 tr\u1ea7m tr\u1ecdng h\u01a1n v\u00e0o bu\u1ed5i t\u1ed1i ho\u1eb7c khi l\u00e0m vi\u1ec7c tr\u00ean m\u00e1y t\u00ednh ho\u1eb7c \u0111\u1ecdc s\u00e1ch trong th\u1eddi gian d\u00e0i. B\u1ec7nh l\u00fd kh\u00f4 m\u1eaft c\u00f3 th\u1ec3 g\u00e2y ra s\u1ef1 kh\u00f3 ch\u1ecbu v\u00e0 \u1ea3nh h\u01b0\u1edfng t\u1edbi ch\u1ee9c n\u0103ng l\u1eabn s\u1ee9c kh\u1ecfe c\u1ee7a m\u1eaft<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Nguy\u00ean nh\u00e2n c\u1ee7a b\u1ec7nh l\u00fd kh\u00f4 m\u1eaft c\u00f3 th\u1ec3 do nhi\u1ec1u y\u1ebfu t\u1ed1 bao g\u1ed3m tu\u1ed5i t\u00e1c, thay \u0111\u1ed5i n\u1ed9i ti\u1ebft t\u1ed1. C\u1ea3 nam v\u00e0 n\u1eef \u0111\u1ec1u c\u00f3 th\u1ec3 b\u1ecb kh\u00f4 m\u1eaft. Tuy nhi\u00ean, n\u00f3 ph\u1ed5 bi\u1ebfn h\u01a1n \u1edf ph\u1ee5 n\u1eef, \u0111\u1eb7c bi\u1ec7t l\u00e0 nh\u1eefng ng\u01b0\u1eddi \u0111\u00e3 tr\u1ea3i qua th\u1eddi k\u1ef3 m\u00e3n kinh. Ngo\u00e0i ra c\u00f2n c\u00f3 nhi\u1ec1u nguy\u00ean nh\u00e2n kh\u00e1c g\u00e2y kh\u00f4 m\u1eaft: m\u1ed9t s\u1ed1 b\u1ec7nh (vi\u00eam kh\u1edbp d\u1ea1ng th\u1ea5p, b\u1ec7nh tuy\u1ebfn gi\u00e1p, b\u1ec7nh lupus ban \u0111\u1ecf,&#8230;), s\u1eed d\u1ee5ng m\u00e1y t\u00ednh ho\u1eb7c thi\u1ebft b\u1ecb \u0111i\u1ec7n t\u1eed trong th\u1eddi gian d\u00e0i, s\u1eed d\u1ee5ng k\u00ednh \u00e1p tr\u00f2ng trong m\u1ed9t th\u1eddi gian d\u00e0i, ph\u1eabu thu\u1eadt kh\u00fac x\u1ea1 m\u1eaft, d\u00f9ng m\u1ed9t s\u1ed1 lo\u1ea1i thu\u1ed1c (thu\u1ed1c l\u1ee3i ti\u1ec3u, thu\u1ed1c ch\u1eb9n beta, thu\u1ed1c d\u1ecb \u1ee9ng, thu\u1ed1c ng\u1ee7, thu\u1ed1c ch\u1ed1ng tr\u1ea7m c\u1ea3m, thu\u1ed1c tr\u1ecb \u1ee3 n\u00f3ng)<\/span><\/p>\n<p><span style=\"font-weight: 400;\">\u0110\u1ec3 \u0111i\u1ec1u tr\u1ecb b\u1ec7nh l\u00fd kh\u00f4 m\u1eaft, c\u00e1c bi\u1ec7n ph\u00e1p kh\u00e1c nhau c\u00f3 th\u1ec3 \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng, bao g\u1ed3m s\u1eed d\u1ee5ng thu\u1ed1c nh\u01b0 nh\u1ecf m\u1eaft v\u00e0 thu\u1ed1c gi\u1ea3m \u0111au, thay \u0111\u1ed5i th\u00f3i quen s\u1eed d\u1ee5ng m\u00e1y t\u00ednh, s\u1eed d\u1ee5ng k\u00ednh \u00e1p tr\u00f2ng v\u00e0 \u00e1p d\u1ee5ng ph\u01b0\u01a1ng ph\u00e1p th\u1ee7 c\u00f4ng \u0111\u1ec3 k\u00edch th\u00edch s\u1ea3n xu\u1ea5t n\u01b0\u1edbc m\u1eaft. Trong tr\u01b0\u1eddng h\u1ee3p nghi\u00eam tr\u1ecdng, ph\u1eabu thu\u1eadt c\u00f3 th\u1ec3 \u0111\u01b0\u1ee3c th\u1ef1c hi\u1ec7n.<\/span><\/p>\n<h2><b>2. S\u01a1 l\u01b0\u1ee3c v\u1ec1 Reproxalap<\/b><\/h2>\n<p><span style=\"font-weight: 400;\">FDA \u0111\u00e3 ch\u1ea5p nh\u1eadn \u0111\u01a1n thu\u1ed1c m\u1edbi (NDA) cho thu\u1ed1c b\u00f4i ngo\u00e0i da Reproxalap, m\u1ed9t lo\u1ea1i thu\u1ed1c m\u1edbi \u0111ang \u0111\u01b0\u1ee3c nghi\u00ean c\u1ee9u \u1ee9ng c\u1eed vi\u00ean \u0111\u1ea7u ti\u00ean trong h\u1ea1ng m\u1ee5c \u0111i\u1ec1u tr\u1ecb c\u00e1c d\u1ea5u hi\u1ec7u v\u00e0 tri\u1ec7u ch\u1ee9ng c\u1ee7a b\u1ec7nh kh\u00f4 m\u1eaft. D\u1ef1a tr\u00ean d\u1eef li\u1ec7u t\u1eeb m\u1ed9t s\u1ed1 th\u1eed nghi\u1ec7m l\u00e2m s\u00e0ng \u1edf giai \u0111o\u1ea1n cu\u1ed1i, Reproxalap c\u00f3 kh\u1ea3 n\u0103ng l\u00e0 m\u1ed9t li\u1ec7u ph\u00e1p nh\u00e3n khoa nhanh ch\u00f3ng v\u00e0 l\u00e2u d\u00e0i cho h\u00e0ng tri\u1ec7u b\u1ec7nh nh\u00e2n m\u1eafc b\u1ec7nh kh\u00f4 m\u1eaft khi c\u00e1c ph\u01b0\u01a1ng ph\u00e1p \u0111i\u1ec1u tr\u1ecb hi\u1ec7n t\u1ea1i kh\u00f4ng kh\u1ea3 quan. C\u1ee5 th\u1ec3, NDA \u0111\u01b0\u1ee3c h\u1ed7 tr\u1ee3 b\u1edfi c\u00e1c k\u1ebft qu\u1ea3 v\u1ec1 t\u00ednh hi\u1ec7u qu\u1ea3 v\u00e0 an to\u00e0n \u0111\u00e3 \u0111\u01b0\u1ee3c c\u00f4ng b\u1ed1 tr\u01b0\u1edbc \u0111\u00e2y t\u1eeb n\u0103m th\u1eed nghi\u1ec7m l\u00e2m s\u00e0ng bao g\u1ed3m d\u1eef li\u1ec7u v\u1ec1 \u0111i\u1ec3m tri\u1ec7u ch\u1ee9ng kh\u00f4 m\u1eaft, \u0111\u1ecf m\u1eaft, x\u00e9t nghi\u1ec7m Schirmer v\u00e0 ph\u00e2n t\u00edch ph\u1ea3n \u1ee9ng \u226510mm c\u1ee7a x\u00e9t nghi\u1ec7m Schirmer. \u0110\u1ec3 \u0111\u00e1nh gi\u00e1 hi\u1ec7u qu\u1ea3 v\u00e0 an to\u00e0n c\u1ee7a thu\u1ed1c, NDA c\u0169ng bao g\u1ed3m c\u00e1c ho\u1ea1t \u0111\u1ed9ng t\u1eeb trong v\u00f2ng v\u00e0i ph\u00fat d\u00f9ng thu\u1ed1c cho \u0111\u1ebfn 12 tu\u1ea7n \u0111i\u1ec1u tr\u1ecb, thi\u1ebft k\u1ebf th\u1eed nghi\u1ec7m l\u00e2m s\u00e0ng nh\u00f3m song song v\u00e0 nh\u00f3m ch\u00e9o, c\u0169ng nh\u01b0 \u0111\u00e1nh gi\u00e1 trong c\u00e1c test kh\u00f4 m\u1eaft v\u00e0 m\u00f4i tr\u01b0\u1eddng t\u1ef1 nhi\u00ean.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Reproxalap, m\u1ed9t \u1ee9ng c\u1eed vi\u00ean thu\u1ed1c m\u1edbi \u0111ang \u0111\u01b0\u1ee3c nghi\u00ean c\u1ee9u b\u1edfi Aldeyra Therapeutics ho\u1ea1t \u0111\u1ed9ng nh\u01b0 ch\u1ea5t \u1ee9c ch\u1ebf c\u00e1c lo\u1ea1i Aldehyde ph\u1ea3n \u1ee9ng (RASP). Trong \u0111\u00f3, . C\u01a1 ch\u1ebf ho\u1ea1t \u0111\u1ed9ng c\u1ee7a Reproxalap \u0111\u00e3 \u0111\u01b0\u1ee3c h\u1ed7 tr\u1ee3 b\u1edfi vi\u1ec7c ch\u1ee9ng minh ho\u1ea1t \u0111\u1ed9ng c\u00f3 li\u00ean quan \u0111\u1ebfn l\u00e2m s\u00e0ng v\u00e0 c\u00f3 \u00fd ngh\u0129a th\u1ed1ng k\u00ea trong nhi\u1ec1u ch\u1ec9 \u0111\u1ecbnh l\u00e2m s\u00e0ng giai \u0111o\u1ea1n cu\u1ed1i kh\u00e1c bi\u1ec7t v\u1ec1 m\u1eb7t sinh l\u00fd. C\u00e1c ph\u00e2n t\u1eed RASP c\u00f3 vai tr\u00f2 ng\u0103n ch\u1eb7n vi\u00eam \u1edf \u0111\u1ea7u nh\u00e1nh c\u1ee7a c\u00e1c m\u1ea1ch m\u00e1u nh\u1ecf \u1edf c\u1ea5p \u0111\u1ed9 t\u1ebf b\u00e0o v\u00e0 \u0111\u01b0\u1ee3c t\u1ea1o ra t\u1eeb qu\u00e1 tr\u00ecnh glycation, oxy h\u00f3a axit amin v\u00e0 peroxy h\u00f3a lipid. Tuy nhi\u00ean, s\u1ed1 l\u01b0\u1ee3ng RASP qu\u00e1 nhi\u1ec1u c\u00f3 th\u1ec3 g\u00e2y ra nh\u1eefng thay \u0111\u1ed5i trong enzym v\u00e0 c\u00e1c k\u00eanh ion, t\u1ea1o ra c\u00e1c ch\u1ea5t n\u1ec1n g\u00e2y vi\u00eam. C\u00e1c ch\u1ea5t \u1ee9c ch\u1ebf RASP \u0111\u01b0\u1ee3c cho l\u00e0 ng\u0103n ch\u1eb7n s\u1ef1 chuy\u1ec3n v\u1ecb NF- kB, k\u00edch ho\u1ea1t h\u1ed3ng c\u1ea7u, t\u1eeb \u0111\u00f3 l\u00e0m ng\u0103n ch\u1eb7n s\u1ef1 gi\u1ea3i ph\u00f3ng Cytokine v\u00e0 gi\u1ea3m m\u1ee9c \u0111\u1ed9 Cytokine v\u00e0 Histamine g\u00e2y vi\u00eam. Ngo\u00e0i ra, gen ALDH2 ch\u1ecbu tr\u00e1ch nhi\u1ec7m chuy\u1ec3n h\u00f3a Aldehyde, \u0111\u01b0\u1ee3c nghi\u00ean c\u1ee9u \u0111\u1ec3 ki\u1ec3m so\u00e1t c\u01a1n \u0111au<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Reproxalap nh\u1ecf m\u1eaft t\u1ea1i ch\u1ed7 \u0111\u00e3 \u0111\u01b0\u1ee3c nghi\u00ean c\u1ee9u tr\u00ean h\u01a1n 2.000 b\u1ec7nh nh\u00e2n m\u00e0 kh\u00f4ng quan s\u00e1t th\u1ea5y m\u1ed1i lo ng\u1ea1i n\u00e0o v\u1ec1 t\u00ednh an to\u00e0n \u0111\u00e1ng k\u1ec3 v\u1ec1 m\u1eb7t l\u00e2m s\u00e0ng; k\u00edch \u1ee9ng nh\u1eb9 v\u00e0 tho\u00e1ng qua t\u1ea1i v\u1ecb tr\u00ed nh\u1ecf thu\u1ed1c l\u00e0 t\u00e1c d\u1ee5ng ph\u1ee5 \u0111\u01b0\u1ee3c b\u00e1o c\u00e1o ph\u1ed5 bi\u1ebfn nh\u1ea5t trong c\u00e1c th\u1eed nghi\u1ec7m l\u00e2m s\u00e0ng.\u00a0<\/span><\/p>\n<h2><strong>3. K\u1ebft lu\u1eadn\u00a0<\/strong><\/h2>\n<p>Nh\u1eefng nghi\u00ean c\u1ee9u v\u1ec1 Reproxalap cho th\u1ea5y r\u1eb1ng n\u00f3 c\u00f3 th\u1ec3 l\u00e0 m\u1ed9t \u1ee9ng c\u1eed vi\u00ean ti\u1ec1m n\u0103ng cho b\u1ec7nh kh\u00f4 m\u1eaft. N\u00f3 c\u00f3 th\u1ec3 gi\u00fap ng\u0103n ch\u1eb7n s\u1ef1 ph\u00e1t tri\u1ec3n c\u1ee7a b\u1ec7nh v\u00e0 t\u0103ng c\u01b0\u1eddng c\u00e1c t\u00e1c d\u1ee5ng l\u00e0m gi\u1ea3m c\u1ee7a b\u1ec7nh. Tuy nhi\u00ean, c\u1ea7n c\u00f3 nh\u1eefng nghi\u00ean c\u1ee9u th\u1ef1c nghi\u1ec7m h\u01a1n \u0111\u1ec3 x\u00e1c \u0111\u1ecbnh hi\u1ec7u qu\u1ea3 c\u1ee7a Reproxalap trong \u0111i\u1ec1u tr\u1ecb b\u1ec7nh kh\u00f4 m\u1eaft.<\/p>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Reproxalap \u0111\u01b0\u1ee3c nghi\u00ean c\u1ee9u v\u00e0 ph\u00e1t tri\u1ec3n b\u1edfi c\u00f4ng ty c\u00f4ng ngh\u1ec7 sinh h\u1ecdc Aldeyra. C\u00e1c nghi\u00ean c\u1ee9u \u0111\u00e3 cho th\u1ea5y r\u1eb1ng Reproxalap c\u00f3 th\u1ec3 gi\u00fap ng\u0103n ch\u1eb7n s\u1ef1 ph\u00e1t tri\u1ec3n c\u1ee7a b\u1ec7nh v\u00e0 t\u0103ng c\u01b0\u1eddng c\u1ea3i thi\u1ec7n tri\u1ec7u ch\u1ee9ng c\u1ee7a b\u1ec7nh kh\u00f4 m\u1eaft.\u00a0 1. C\u00e1c th\u00f4ng tin v\u1ec1 b\u1ec7nh l\u00fd kh\u00f4 m\u1eaft\u00a0 1.1 C\u1ea5u [&hellip;]<\/p>\n","protected":false},"author":54,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[12],"tags":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v20.4 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Reproxalap: \u1ee9ng c\u1eed vi\u00ean ti\u1ec1m n\u0103ng cho b\u1ec7nh kh\u00f4 m\u1eaft - Vinmec<\/title>\n<meta name=\"description\" content=\"C\u00e1c nghi\u00ean c\u1ee9u cho th\u1ea5y r\u1eb1ng ti\u1ec1m n\u0103ng c\u1ee7a Reproxalap gi\u00fap ng\u0103n ch\u1eb7n s\u1ef1 ph\u00e1t tri\u1ec3n v\u00e0 t\u0103ng c\u01b0\u1eddng c\u1ea3i thi\u1ec7n tri\u1ec7u ch\u1ee9ng c\u1ee7a b\u1ec7nh kh\u00f4 m\u1eaft.\u00a0\" \/>\n<meta name=\"robots\" content=\"noindex, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Reproxalap: \u1ee9ng c\u1eed vi\u00ean ti\u1ec1m n\u0103ng cho b\u1ec7nh kh\u00f4 m\u1eaft - 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