{"id":32287,"date":"2023-05-13T11:44:48","date_gmt":"2023-05-13T04:44:48","guid":{"rendered":"http:\/\/noithathoaphat.in\/ctv\/?p=32287"},"modified":"2023-05-13T11:44:48","modified_gmt":"2023-05-13T04:44:48","slug":"tuong-tac-giua-mdma-voi-cac-loai-thuoc-than-kinh-khac","status":"publish","type":"post","link":"http:\/\/noithathoaphat.in\/ctv\/index.php\/2023\/05\/13\/tuong-tac-giua-mdma-voi-cac-loai-thuoc-than-kinh-khac\/","title":{"rendered":"T\u01b0\u01a1ng t\u00e1c gi\u1eefa MDMA v\u1edbi c\u00e1c lo\u1ea1i thu\u1ed1c th\u1ea7n kinh kh\u00e1c"},"content":{"rendered":"

MDMA (3,4-methylenedioxymethamphetamine) l\u00e0 m\u1ed9t ch\u1ea5t k\u00edch th\u00edch m\u1ea1nh \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng r\u1ed9ng r\u00e3i do t\u00e1c d\u1ee5ng khi\u1ebfn ng\u01b0\u1eddi d\u00f9ng c\u1ea3m th\u1ea5y ph\u1ea5n kh\u00edch v\u00e0 c\u00f3 tr\u1ea1ng th\u00e1i tinh th\u1ea7n t\u1ed1t h\u01a1n. Nh\u01b0ng kh\u00f4ng v\u00ec v\u1eady m\u00e0 b\u1ecf qua nhi\u1ec1u t\u00e1c d\u1ee5ng ph\u1ee5 v\u00e0 nguy hi\u1ec3m cho s\u1ee9c kh\u1ecfe khi d\u00f9ng c\u00f9ng l\u00fac v\u1edbi nhi\u1ec1u lo\u1ea1i thu\u1ed1c th\u1ea7n kinh kh\u00e1c. Trong b\u00e0i vi\u1ebft n\u00e0y, ch\u00fang ta s\u1ebd t\u00ecm hi\u1ec3u v\u1ec1 t\u01b0\u01a1ng t\u00e1c c\u1ee7a MDMA v\u1edbi c\u00e1c lo\u1ea1i thu\u1ed1c th\u1ea7n kinh kh\u00e1c v\u00e0 nh\u1eefng t\u00e1c \u0111\u1ed9ng c\u1ee7a s\u1ef1 k\u1ebft h\u1ee3p gi\u1eefa ch\u00fang<\/b><\/p>\n

1.T\u00ecm hi\u1ec3u v\u1ec1 thu\u1ed1c MDMA<\/b><\/h2>\n

Gi\u1edbi thi\u1ec7u: 3,4-methylenedioxy-methamphetamine (MDMA) l\u00e0 m\u1ed9t lo\u1ea1i ma t\u00fay t\u1ed5ng h\u1ee3p l\u00e0m thay \u0111\u1ed5i t\u00e2m tr\u1ea1ng v\u00e0 nh\u1eadn th\u1ee9c. MDMA c\u00f3 c\u1ea5u t\u1ea1o h\u00f3a h\u1ecdc t\u01b0\u01a1ng t\u1ef1 v\u1edbi c\u1ea3 ch\u1ea5t k\u00edch th\u00edch v\u00e0 ch\u1ea5t g\u00e2y \u1ea3o gi\u00e1c, t\u1eeb \u0111\u00f3 t\u1ea1o ra c\u1ea3m gi\u00e1c gia t\u0103ng n\u0103ng l\u01b0\u1ee3ng, kho\u00e1i c\u1ea3m, c\u1ea3m x\u00fac \u1ea5m \u00e1p v\u00e0 nh\u1eadn th\u1ee9c v\u1ec1 c\u1ea3m gi\u00e1c v\u00e0 th\u1eddi gian b\u1ecb sai. MDMA th\u01b0\u1eddng \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng v\u00e0 bi\u1ebft \u0111\u1ebfn r\u1ed9ng r\u00e3i v\u1edbi t\u00ean g\u1ecdi Ecstasy ho\u1eb7c Molly. MDMA th\u01b0\u1eddng \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng d\u01b0\u1edbi d\u1ea1ng vi\u00ean nang ho\u1eb7c vi\u00ean n\u00e9n ho\u1eb7c d\u1ea1ng l\u1ecfng, h\u00edt b\u1ed9t.\u00a0<\/span><\/p>\n

\"Ecstasy
Ecstasy (MDMA)<\/figcaption><\/figure>\n

C\u01a1 ch\u1ebf ho\u1ea1t \u0111\u1ed9ng: MDMA l\u00e0m t\u0103ng ho\u1ea1t \u0111\u1ed9ng c\u1ee7a c\u00e1c ch\u1ea5t sau trong n\u00e3o<\/span><\/p>\n\n\n\n\n\n\n
\n

Hormone\u00a0<\/b><\/p>\n<\/td>\n

\n

T\u00e1c \u0111\u1ed9ng\u00a0<\/b><\/p>\n<\/td>\n<\/tr>\n

Dopamine<\/span><\/td>\nT\u1ea1o n\u0103ng l\u01b0\u1ee3ng\u00a0<\/span><\/td>\n<\/tr>\n
Norepinephrine\u00a0<\/span><\/td>\nT\u0103ng nh\u1ecbp tim v\u00e0 huy\u1ebft \u00e1p<\/span><\/p>\n

(\u0111\u1eb7c bi\u1ec7t nguy hi\u1ec3m \u0111\u1ed1i v\u1edbi nh\u1eefng ng\u01b0\u1eddi c\u00f3 v\u1ea5n \u0111\u1ec1 v\u1ec1 tim v\u00e0 m\u1ea1ch m\u00e1u)<\/span><\/td>\n<\/tr>\n

Serotonin<\/span><\/td>\n\u1ea2nh h\u01b0\u1edfng \u0111\u1ebfn t\u00e2m tr\u1ea1ng, s\u1ef1 th\u00e8m \u0103n, gi\u1ea5c ng\u1ee7 v\u00e0 c\u00e1c ch\u1ee9ng n\u0103ng kh\u00e1c<\/span><\/p>\n

K\u00edch ho\u1ea1t hormone \u1ea3nh h\u01b0\u1edfng \u0111\u1ebfn h\u01b0ng ph\u1ea5n v\u00e0 t\u00ecnh d\u1ee5c\u00a0<\/span><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

T\u00e1c d\u1ee5ng ph\u1ee5: T\u00e1c d\u1ee5ng c\u1ee7a MDMA k\u00e9o d\u00e0i kho\u1ea3ng 3 \u0111\u1ebfn 6 gi\u1edd. Trong su\u1ed1t th\u1eddi gian s\u1eed d\u1ee5ng, c\u00e1c t\u00e1c d\u1ee5ng ph\u1ee5 c\u00f3 th\u1ec3 g\u1eb7p bao g\u1ed3m c\u00e1u g\u1eaft, b\u1ed1c \u0111\u1ed3ng v\u00e0 hung h\u0103ng, tr\u1ea7m c\u1ea3m, c\u00e1c v\u1ea5n \u0111\u1ec1 v\u1ec1 gi\u1ea5c ng\u1ee7, lo l\u1eafng, c\u00e1c v\u1ea5n \u0111\u1ec1 v\u1ec1 tr\u00ed nh\u1edb v\u00e0 t\u1eadp trung, gi\u1ea3m s\u1ef1 th\u00e8m \u0103n, gi\u1ea3m h\u1ee9ng th\u00fa<\/span><\/p>\n

\u1ea2nh h\u01b0\u1edfng \u0111\u1ebfn s\u1ee9c kh\u1ecfe: MDMA li\u1ec1u cao c\u00f3 th\u1ec3 \u1ea3nh h\u01b0\u1edfng \u0111\u1ebfn kh\u1ea3 n\u0103ng \u0111i\u1ec1u ch\u1ec9nh nhi\u1ec7t \u0111\u1ed9 c\u1ee7a c\u01a1 th\u1ec3, t\u1eeb \u0111\u00f3 d\u1eabn \u0111\u1ebfn nhi\u1ec7t \u0111\u1ed9 c\u01a1 th\u1ec3 t\u0103ng \u0111\u1ed9t bi\u1ebfn, \u0111\u00f4i khi c\u00f3 th\u1ec3 d\u1eabn \u0111\u1ebfn suy gan, th\u1eadn ho\u1eb7c tim ho\u1eb7c th\u1eadm ch\u00ed t\u1eed vong. M\u1ed9t s\u1ed1 nghi\u00ean c\u1ee9u ch\u1ec9 ra c\u00e1c d\u1ea5u hi\u1ec7u nghi\u1ec7n khi l\u1ea1m d\u1ee5ng thu\u1ed1c: m\u1ec7t m\u1ecfi, \u0103n m\u1ea5t ngon, tr\u1ea7m c\u1ea3m, kh\u00f3 t\u1eadp trung\u00a0<\/span><\/p>\n

Gi\u00e1 tr\u1ecb trong \u0111i\u1ec1u tr\u1ecb: MDMA l\u1ea7n \u0111\u1ea7u ti\u00ean \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng v\u00e0o nh\u1eefng n\u0103m 1970 nh\u01b0 m\u1ed9t c\u00f4ng c\u1ee5 h\u1ed7 tr\u1ee3 trong li\u1ec7u ph\u00e1p t\u00e2m l\u00fd. M\u1eb7c d\u00f9 thu\u1ed1c kh\u00f4ng c\u00f3 s\u1ef1 ch\u1ea5p thu\u1eadn c\u1ee7a C\u1ee5c Qu\u1ea3n l\u00fd Th\u1ef1c ph\u1ea9m v\u00e0 D\u01b0\u1ee3c ph\u1ea9m Hoa K\u1ef3 (FDA) nh\u01b0ng m\u1ed9t s\u1ed1 nh\u00e0 nghi\u00ean c\u1ee9u v\u1eabn quan t\u00e2m v\u00e0 \u0111\u00e1nh gi\u00e1 hi\u1ec7u qu\u1ea3 nh\u01b0 m\u1ed9t ph\u01b0\u01a1ng ph\u00e1p h\u1ed7 tr\u1ee3 \u0111i\u1ec1u tr\u1ecb kh\u1ea3 thi cho ch\u1ee9ng r\u1ed1i lo\u1ea1n c\u0103ng th\u1eb3ng sau ch\u1ea5n th\u01b0\u01a1ng (PTSD), cho s\u1ef1 lo l\u1eafng \u1edf nh\u1eefng b\u1ec7nh nh\u00e2n m\u1eafc b\u1ec7nh nan y; v\u00e0 lo l\u1eafng x\u00e3 h\u1ed9i \u1edf ng\u01b0\u1eddi l\u1edbn m\u1eafc ch\u1ee9ng t\u1ef1 k\u1ef7<\/span><\/p>\n

2. T\u01b0\u01a1ng t\u00e1c thu\u1ed1c khi s\u1eed d\u1ee5ng \u0111\u1ed3ng th\u1eddi v\u1edbi MDMA<\/b><\/h2>\n

2.1 T\u01b0\u01a1ng t\u00e1c gi\u1eefa MDMA v\u00e0 Ethanol (EtOH)<\/span><\/h3>\n

\u1ede ng\u01b0\u1eddi, EtOH k\u00e9o d\u00e0i t\u00e1c d\u1ee5ng h\u01b0ng ph\u1ea5n v\u00e0 c\u1ea3m gi\u00e1c h\u1ea1nh ph\u00fac c\u1ee7a MDMA. M\u1ed9t s\u1ed1 nghi\u00ean c\u1ee9u \u0111\u00e3 ch\u1ec9 ra r\u1eb1ng s\u1ef1 k\u1ebft h\u1ee3p n\u00e0y c\u00f3 th\u1ec3 l\u00e0m t\u0103ng t\u1ea7n su\u1ea5t nh\u1ecbp tim v\u00e0 huy\u1ebft \u00e1p, g\u00e2y ra c\u1ea3m gi\u00e1c lo l\u1eafng v\u00e0 kh\u00f3 ch\u1ecbu, c\u0169ng nh\u01b0 l\u00e0m gi\u1ea3m kh\u1ea3 n\u0103ng ki\u1ec3m so\u00e1t \u0111\u1ed9ng t\u00e1c v\u00e0 n\u00f3i chuy\u1ec7n. Ngo\u00e0i ra, s\u1ef1 k\u1ebft h\u1ee3p gi\u1eefa MDMA v\u00e0 EtOH c\u0169ng c\u00f3 th\u1ec3 g\u00e2y ra c\u00e1c v\u1ea5n \u0111\u1ec1 v\u1ec1 gan v\u00e0 th\u1eadn, t\u0103ng nguy c\u01a1 r\u1ed1i lo\u1ea1n t\u00e2m l\u00fd v\u00e0 g\u00e2y ra c\u00e1c t\u00e1c d\u1ee5ng ph\u1ee5 nguy hi\u1ec3m kh\u00e1c nh\u01b0 co gi\u1eadt, m\u1ea5t tr\u00ed nh\u1edb v\u00e0 \u0111\u1ed9t qu\u1ef5. Do \u0111\u00f3, khi s\u1eed d\u1ee5ng MDMA ho\u1eb7c EtOH, c\u1ea7n tu\u00e2n th\u1ee7 c\u00e1c h\u01b0\u1edbng d\u1eabn s\u1eed d\u1ee5ng an to\u00e0n v\u00e0 h\u1ea1n ch\u1ebf s\u1eed d\u1ee5ng \u0111\u1ed3ng th\u1eddi hai ch\u1ea5t n\u00e0y \u0111\u1ec3 tr\u00e1nh c\u00e1c t\u00e1c d\u1ee5ng kh\u00f4ng mong mu\u1ed1n v\u00e0 nguy hi\u1ec3m cho s\u1ee9c kh\u1ecfe<\/span><\/p>\n

2.2 T\u01b0\u01a1ng t\u00e1c gi\u1eefa c\u1ea7n sa v\u00e0 MDMA<\/span><\/h3>\n

Trong s\u1ed1 nhi\u1ec1u h\u00f3a ch\u1ea5t th\u1ea7n kinh c\u00f3 trong c\u1ea7n sa<\/a>, ho\u1ea1t ch\u1ea5t m\u1ea1nh nh\u1ea5t l\u00e0 \u03949-trans-tetrahydrocannabinol. C\u1ea7n sa l\u00e0 m\u1ed9t trong nh\u1eefng lo\u1ea1i thu\u1ed1c \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng ph\u1ed5 bi\u1ebfn nh\u1ea5t v\u1edbi MDMA. Vi\u1ec7c s\u1eed d\u1ee5ng s\u1ef1 k\u1ebft h\u1ee3p n\u00e0y tr\u00ean to\u00e0n th\u1ebf gi\u1edbi \u0111\u01b0\u1ee3c \u01b0\u1edbc t\u00ednh l\u00e0 t\u1eeb 73% \u0111\u1ebfn 100% trong s\u1ed1 nh\u1eefng ng\u01b0\u1eddi tr\u1ebb tu\u1ed5i. Khi d\u00f9ng chung c\u1ea7n sa v\u00e0 MDMA l\u00e0m gi\u1ea3m b\u1edbt c\u00e1c t\u00e1c \u0111\u1ed9ng kh\u00f3 ch\u1ecbu m\u00e0 MDMA g\u00e2y ra, ch\u1eb3ng h\u1ea1n nh\u01b0 suy gi\u1ea3m c\u1ea3m x\u00fac, ch\u1ee9ng kh\u00f3 nu\u1ed1t v\u00e0 tr\u1ea7m c\u1ea3m, l\u00e0m gi\u1ea3m c\u00e1c tri\u1ec7u ch\u1ee9ng soma. Tuy nhi\u00ean, s\u1ef1 k\u1ebft h\u1ee3p n\u00e0y c\u00f3 th\u1ec3 ti\u1ec1m \u1ea9n nhi\u1ec1u m\u1ed1i nguy h\u1ea1i cho s\u1ee9c kh\u1ecfe: r\u1ed1i lo\u1ea1n t\u00e2m l\u00fd (b\u1ed1c \u0111\u1ed3ng, lo l\u1eafng, ph\u00e0n n\u00e0n v\u1ec1 c\u01a1 th\u1ec3, c\u00e1c ki\u1ec3u \u00e1m \u1ea3nh c\u01b0\u1ee1ng ch\u1ebf), h\u00e0nh vi lo\u1ea1n th\u1ea7n. Ng\u01b0\u1eddi s\u1eed d\u1ee5ng MDMA+c\u1ea7n sa c\u0169ng \u0111\u01b0\u1ee3c b\u00e1o c\u00e1o gi\u1ea3m tr\u00ed nh\u1edb, gi\u1ea3m kh\u1ea3 n\u0103ng ti\u1ebfp thu, t\u1ed1c \u0111\u1ed9 x\u1eed l\u00fd th\u00f4ng tin gi\u1ea3m \u0111\u1ed3ng th\u1eddi suy gi\u1ea3m nh\u1eadn th\u1ee9c. Ngo\u00e0i ra, ng\u01b0\u1eddi ta \u0111\u00e3 ch\u1ee9ng minh r\u1eb1ng s\u1ef1 k\u1ebft h\u1ee3p c\u1ee7a hai ch\u1ea5t n\u00e0y t\u1ea1o ra hi\u1ec7u \u1ee9ng ph\u1ee5 l\u00e0m gi\u1ea3m nh\u1eadn th\u1ee9c th\u1ecb gi\u00e1c v\u00e0 nh\u1eadn th\u1ee9c chuy\u1ec3n \u0111\u1ed9ng. C\u00f3 b\u1eb1ng ch\u1ee9ng cho th\u1ea5y vi\u1ec7c s\u1eed d\u1ee5ng k\u00e9o d\u00e0i c\u00f3 li\u00ean quan \u0111\u1ebfn s\u1ef1 thay \u0111\u1ed5i l\u00e2u d\u00e0i ch\u1ee9c n\u0103ng mi\u1ec5n d\u1ecbch, d\u1eabn \u0111\u1ebfn t\u0103ng kh\u1ea3 n\u0103ng nhi\u1ec5m tr\u00f9ng nh\u1eb9 v\u00e0 c\u00e1c r\u1ed1i lo\u1ea1n li\u00ean quan \u0111\u1ebfn mi\u1ec5n d\u1ecbch kh\u00e1c nhau. H\u01a1n n\u1eefa duy tr\u00ec s\u1eed d\u1ee5ng k\u1ebft h\u1ee3p gi\u1eefa hai ch\u1ea5t c\u00f3 th\u1ec3 l\u00e0m t\u0103ng ho\u1ea1t \u0111\u1ed9ng n\u1ed9i ti\u1ebft do MDMA g\u00e2y ra bao g\u1ed3m t\u0103ng gi\u1ea3i ph\u00f3ng Vasopressin, t\u0103ng Oxytocin huy\u1ebft t\u01b0\u01a1ng v\u00e0 gi\u1ea3m ph\u1ea3n \u1ee9ng Prolactin v\u00e0 Cortisol \u0111\u1ed1i v\u1edbi ch\u1ea5t ch\u1ee7 v\u1eadn Serotonergic, D\u2013 fenfluramine. Nghi\u00ean c\u1ee9u v\u00e0o n\u0103m 2009 c\u0169ng \u0111\u00e3 b\u00e1o c\u00e1o r\u1eb1ng THC v\u00e0 MDMA t\u1ea1o ra t\u00e1c d\u1ee5ng ph\u1ee5 trong vi\u1ec7c t\u0103ng nh\u1ecbp tim<\/span><\/p>\n

2.3 T\u01b0\u01a1ng t\u00e1c gi\u1eefa MDMA v\u00e0 Cocaine<\/span><\/h3>\n

C\u00e1c nghi\u00ean c\u1ee9u kh\u1ea3o s\u00e1t ch\u1ec9 ra r\u1eb1ng 46% ng\u01b0\u1eddi d\u00f9ng MDMA c\u0169ng s\u1eed d\u1ee5ng Cocaine<\/a>. Khi s\u1eed d\u1ee5ng c\u00f9ng l\u00fac MDMA v\u00e0 Cocaine, t\u01b0\u01a1ng t\u00e1c gi\u1eefa hai ch\u1ea5t n\u00e0y c\u00f3 th\u1ec3 t\u0103ng c\u01b0\u1eddng c\u00e1c t\u00e1c d\u1ee5ng k\u00edch th\u00edch v\u00e0 c\u1ea3m gi\u00e1c ph\u1ea5n kh\u00edch, tuy nhi\u00ean, \u0111\u1ed3ng th\u1eddi c\u0169ng t\u0103ng nguy c\u01a1 c\u00e1c t\u00e1c d\u1ee5ng ph\u1ee5 v\u00e0 nguy hi\u1ec3m cho s\u1ee9c kh\u1ecfe nh\u01b0: (1) T\u0103ng huy\u1ebft \u00e1p v\u00e0 nh\u1ecbp tim, g\u00e2y nguy hi\u1ec3m \u0111\u1ebfn s\u1ee9c kh\u1ecfe tim m\u1ea1ch v\u00e0 g\u00e2y ra r\u1ed1i lo\u1ea1n nh\u1ecbp tim, (2) G\u00e2y ra stress v\u00e0 n\u1ed7i lo l\u1eafng, t\u0103ng nguy c\u01a1 r\u1ed1i lo\u1ea1n t\u00e2m l\u00fd v\u00e0 suy gi\u1ea3m ch\u1ee9c n\u0103ng t\u00e2m l\u00fd, (3) G\u00e2y ra c\u00e1c tri\u1ec7u ch\u1ee9ng nh\u01b0 ch\u00f3ng m\u1eb7t, bu\u1ed3n n\u00f4n v\u00e0 m\u1ea5t ng\u1ee7, (4) T\u0103ng nguy c\u01a1 \u0111\u1ed9t qu\u1ef5 v\u00e0 c\u00e1c v\u1ea5n \u0111\u1ec1 v\u1ec1 gan v\u00e0 th\u1eadn<\/span><\/p>\n

2.4 T\u01b0\u01a1ng t\u00e1c gi\u1eefa MDMA v\u00e0 c\u00e1c ch\u1ea5t d\u1eabn xu\u1ea5t Amphetamine kh\u00e1c<\/span><\/h3>\n

Methamphetamine (METH) l\u00e0 m\u1ed9t ch\u1ea5t k\u00edch th\u00edch m\u1ea1nh. Vi\u1ec7c s\u1eed d\u1ee5ng MDMA+METH th\u01b0\u1eddng xuy\u00ean \u0111\u00e3 \u0111\u01b0\u1ee3c b\u00e1o c\u00e1o l\u00e0 g\u00e2y ra nh\u1eefng thay \u0111\u1ed5i nghi\u00eam tr\u1ecdng v\u1ec1 l\u00e2u d\u00e0i v\u1ec1 nh\u1eadn th\u1ee9c, h\u00e0nh vi v\u00e0 th\u1ea7n kinh. C\u1ee5 th\u1ec3, l\u00e0m gi\u1ea3m m\u1eadt \u0111\u1ed9 DAT trong giai \u0111o\u1ea1n \u0111\u1ea7u s\u1eed d\u1ee5ng thu\u1ed1c. \u0110\u1ed9c t\u00ednh th\u1ea7n kinh MDMA+METH c\u00f3 th\u1ec3 \u0111\u01b0\u1ee3c g\u00e2y ra b\u1edfi stress oxy h\u00f3a v\u00e0 s\u1ea3n xu\u1ea5t g\u1ed1c t\u1ef1 do. B\u00ean c\u1ea1nh \u0111\u00f3, Para-Methoxyamphetamine (PMA) c\u0169ng l\u00e0 m\u1ed9t trong nh\u1eefng lo\u1ea1i Amphetamine \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng r\u1ed9ng r\u00e3i nh\u1ea5t. C\u00e1c d\u1ea5u hi\u1ec7u l\u00e2m s\u00e0ng c\u1ee7a ng\u1ed9 \u0111\u1ed9c PMA c\u0169ng t\u01b0\u01a1ng t\u1ef1 nh\u01b0 c\u1ee7a MDMA. Do \u0111\u00f3, c\u00f3 b\u1eb1ng ch\u1ee9ng cho th\u1ea5y r\u1eb1ng MDMA + PMA c\u00f3 \u0111\u1ed9c t\u00ednh cao th\u1eadm ch\u00ed nhi\u1ec1u tr\u01b0\u1eddng h\u1ee3p t\u1eed vong.\u00a0<\/span><\/p>\n

2.5 T\u01b0\u01a1ng t\u00e1c gi\u1eefa MDMA v\u00e0 Caffein<\/span><\/h3>\n

Caffeine (m\u1ed9t xanthine \u0111\u00e3 methyl h\u00f3a) l\u00e0 m\u1ed9t ch\u1ea5t k\u00edch th\u00edch th\u1ea7n kinh \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng tr\u00ean to\u00e0n th\u1ebf gi\u1edbi. Caffein ph\u1ed1i h\u1ee3p v\u1edbi MDMA l\u00e0m t\u0103ng th\u00e2n nhi\u1ec7t, l\u00e0m gi\u1ea3m l\u00e2u d\u00e0i 5-HT v\u00e0 ch\u1ea5t chuy\u1ec3n h\u00f3a c\u1ee7a n\u00f3 (Acid 5-hydroxyindoleacetic) \u1edf nhi\u1ec1u v\u00f9ng c\u1ee7a n\u00e3o. Do \u0111\u00f3, Caffein t\u1ea1o \u0111i\u1ec1u ki\u1ec7n cho \u0111\u1ed9c t\u00ednh c\u1ea5p t\u00ednh v\u00e0 l\u00e2u d\u00e0i li\u00ean quan \u0111\u1ebfn MDMA. M\u1ed9t s\u1ed1 nghi\u00ean c\u1ee9u cho th\u1ea5y Caffein l\u00e0m t\u0103ng \u0111\u1ed9c t\u00ednh MDMA ch\u1ee7 y\u1ebfu th\u00f4ng qua ho\u1ea1t \u0111\u1ed9ng c\u1ee7a Dopamine D1. Ngo\u00e0i ra, Caffein ng\u0103n ch\u1eb7n c\u1ea3 th\u1ee5 th\u1ec3 Adenosine A1 v\u00e0 A2 n\u00ean l\u00e0m t\u0103ng kh\u1ea3 n\u0103ng gi\u1ea3i ph\u00f3ng DA<\/span><\/p>\n

2.6 T\u01b0\u01a1ng t\u00e1c gi\u1eefa MDMA v\u00e0 c\u00e1c lo\u1ea1i thu\u1ed1c k\u00edch th\u00edch kh\u00e1c\u00a0<\/span><\/h3>\n

MDMA th\u01b0\u1eddng \u0111\u01b0\u1ee3c k\u1ebft h\u1ee3p v\u1edbi c\u00e1c lo\u1ea1i thu\u1ed1c t\u00e1c d\u1ee5ng k\u00edch th\u00edch kh\u00e1c: LSD (60%), Psilocybin (56%), Barbiturat-Benzodiazepin (38%) v\u00e0 thu\u1ed1c phi\u1ec7n (23%). Trong \u0111\u00f3, GHB l\u00e0 m\u1ed9t ch\u1ea5t d\u1eabn truy\u1ec1n th\u1ea7n kinh \u1ee9c ch\u1ebf n\u1ed9i sinh \u0111\u01b0\u1ee3c t\u1ed5ng h\u1ee3p t\u1eeb acid gamma-aminobutyric (GABA). GHB \u0111\u00f4i khi \u0111\u01b0\u1ee3c k\u1ebft h\u1ee3p v\u1edbi MDMA v\u00e0 t\u01b0\u01a1ng t\u00e1c gi\u1eefa GHB v\u00e0 MDMA c\u00f3 th\u1ec3 d\u1eabn \u0111\u1ebfn s\u1ef1 c\u1ea1nh tranh v\u1ec1 \u0111\u1ecba \u0111i\u1ec3m k\u1ebft n\u1ed1i tr\u00ean c\u00e1c t\u1ebf b\u00e0o th\u1ea7n kinh l\u00e0m t\u0103ng h\u00e0m l\u01b0\u1ee3ng Dopamine v\u00e0 Serotonin trong n\u00e3o g\u00e2y ra c\u00e1c t\u00e1c d\u1ee5ng ph\u1ee5 nh\u01b0 r\u1ed1i lo\u1ea1n t\u00e2m l\u00fd, t\u0103ng nguy c\u01a1 tai n\u1ea1n v\u00e0 nguy c\u01a1 r\u1ed1i lo\u1ea1n nh\u1ecbp tim.\u00a0<\/span><\/p>\n

3. K\u1ebft lu\u1eadn\u00a0<\/b><\/h2>\n

MDMA l\u00e0 m\u1ed9t ch\u1ea5t k\u00edch th\u00edch m\u1ea1nh c\u00f3 t\u00e1c d\u1ee5ng t\u00e2m l\u00fd v\u00e0 l\u00e0m t\u0103ng n\u1ed3ng \u0111\u1ed9 Serotonin trong n\u00e3o, khi\u1ebfn ng\u01b0\u1eddi d\u00f9ng c\u1ea3m th\u1ea5y ph\u1ea5n kh\u00edch v\u00e0 c\u00f3 tr\u1ea1ng th\u00e1i tinh th\u1ea7n t\u1ed1t h\u01a1n. Tuy nhi\u00ean, khi s\u1eed d\u1ee5ng c\u00f9ng l\u00fac v\u1edbi c\u00e1c lo\u1ea1i thu\u1ed1c th\u1ea7n kinh kh\u00e1c, t\u01b0\u01a1ng t\u00e1c gi\u1eefa hai lo\u1ea1i thu\u1ed1c c\u00f3 th\u1ec3 g\u00e2y ra c\u00e1c t\u00e1c d\u1ee5ng ph\u1ee5 v\u00e0 nguy hi\u1ec3m cho s\u1ee9c kh\u1ecfe ng\u01b0\u1eddi d\u00f9ng. Do \u0111\u00f3, vi\u1ec7c s\u1eed d\u1ee5ng MDMA c\u1ea7n \u0111\u01b0\u1ee3c th\u1ef1c hi\u1ec7n c\u1ea9n th\u1eadn v\u00e0 ch\u1ec9 d\u01b0\u1edbi s\u1ef1 gi\u00e1m s\u00e1t c\u1ee7a c\u00e1c chuy\u00ean gia y t\u1ebf.<\/span><\/p>\n

 <\/p>\n","protected":false},"excerpt":{"rendered":"

MDMA (3,4-methylenedioxymethamphetamine) l\u00e0 m\u1ed9t ch\u1ea5t k\u00edch th\u00edch m\u1ea1nh \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng r\u1ed9ng r\u00e3i do t\u00e1c d\u1ee5ng khi\u1ebfn ng\u01b0\u1eddi d\u00f9ng c\u1ea3m th\u1ea5y ph\u1ea5n kh\u00edch v\u00e0 c\u00f3 tr\u1ea1ng th\u00e1i tinh th\u1ea7n t\u1ed1t h\u01a1n. Nh\u01b0ng kh\u00f4ng v\u00ec v\u1eady m\u00e0 b\u1ecf qua nhi\u1ec1u t\u00e1c d\u1ee5ng ph\u1ee5 v\u00e0 nguy hi\u1ec3m cho s\u1ee9c kh\u1ecfe khi d\u00f9ng c\u00f9ng l\u00fac v\u1edbi nhi\u1ec1u lo\u1ea1i […]<\/p>\n","protected":false},"author":54,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[12],"tags":[],"yoast_head":"\nT\u01b0\u01a1ng t\u00e1c gi\u1eefa MDMA v\u1edbi c\u00e1c lo\u1ea1i thu\u1ed1c th\u1ea7n kinh kh\u00e1c<\/title>\n<meta name=\"description\" content=\"T\u01b0\u01a1ng t\u00e1c c\u1ee7a MDMA v\u1edbi c\u00e1c lo\u1ea1i thu\u1ed1c th\u1ea7n kinh kh\u00e1c c\u1ea7n \u0111\u01b0\u1ee3c ki\u1ec3m so\u00e1t khi s\u1eed d\u1ee5ng \u0111\u1ec3 tr\u00e1nh g\u00e2y nhi\u1ec1u t\u00e1c d\u1ee5ng ph\u1ee5 nghi\u00eam tr\u1ecdng\" \/>\n<meta name=\"robots\" content=\"noindex, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<meta property=\"og:locale\" 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