{"id":32178,"date":"2023-05-10T03:46:44","date_gmt":"2023-05-09T20:46:44","guid":{"rendered":"http:\/\/noithathoaphat.in\/ctv\/?p=32178"},"modified":"2023-05-10T03:46:44","modified_gmt":"2023-05-09T20:46:44","slug":"lumryz-thuoc-moi-dieu-tri-chung-ngu-ru-duoc-fda-chap-thuan","status":"publish","type":"post","link":"http:\/\/noithathoaphat.in\/ctv\/index.php\/2023\/05\/10\/lumryz-thuoc-moi-dieu-tri-chung-ngu-ru-duoc-fda-chap-thuan\/","title":{"rendered":"Thu\u1ed1c m\u1edbi \u0111i\u1ec1u tr\u1ecb ch\u1ee9ng ng\u1ee7 r\u0169 – Lumryz \u0111\u01b0\u1ee3c FDA ch\u1ea5p thu\u1eadn"},"content":{"rendered":"

Ch\u1ee9ng ng\u1ee7 r\u0169 l\u00e0 m\u1ed9t r\u1ed1i lo\u1ea1n gi\u1ea5c ng\u1ee7 g\u00e2y ra s\u1ef1 m\u1ea5t ki\u1ec3m so\u00e1t gi\u1ea5c ng\u1ee7 v\u00e0o ban ng\u00e0y v\u00e0 c\u00e1c c\u01a1n m\u1ed9ng kinh hoang t\u01b0\u1edfng v\u00e0o ban \u0111\u00eam. \u0110\u00e2y l\u00e0 m\u1ed9t b\u1ec7nh r\u1ea5t kh\u00f3 ch\u1ecbu v\u00e0 \u1ea3nh h\u01b0\u1edfng \u0111\u1ebfn ch\u1ea5t l\u01b0\u1ee3ng cu\u1ed9c s\u1ed1ng c\u1ee7a ng\u01b0\u1eddi b\u1ec7nh. Natri oxybate l\u00e0 m\u1ed9t trong nh\u1eefng ho\u1ea1t ch\u1ea5t \u0111\u01b0\u1ee3c d\u00f9ng \u0111\u1ec3 tr\u1ecb b\u1ec7nh, d\u00f9ng 2 l\u1ea7n m\u1ed9t ng\u00e0y. V\u1edbi c\u00f4ng th\u1ee9c thu\u1ed1c ph\u00f3ng th\u00edch k\u00e9o d\u00e0i m\u1edbi, bi\u1ec7t d\u01b0\u1ee3c Lumryz, ng\u01b0\u1eddi b\u1ec7nh ch\u1ec9 c\u1ea7n d\u00f9ng thu\u1ed1c 1 l\u1ea7n m\u1ed9t ng\u00e0y.<\/p>\n

1. Gi\u1edbi thi\u1ec7u v\u1ec1 ch\u1ee9ng ng\u1ee7 r\u0169<\/h2>\n

1.1. Ch\u1ee9ng ng\u1ee7 r\u0169 l\u00e0 g\u00ec?<\/h3>\n

Ch\u1ee9ng ng\u1ee7 r\u0169 (narcolepsy)<\/a> l\u00e0 m\u1ed9t r\u1ed1i lo\u1ea1n gi\u1ea5c ng\u1ee7 m\u00e0 trong \u0111\u00f3 ng\u01b0\u1eddi b\u1ec7nh c\u00f3 xu h\u01b0\u1edbng \u0111\u1ed9t ng\u1ed9t ng\u1ee7 v\u00e0o ban ng\u00e0y m\u00e0 kh\u00f4ng th\u1ec3 ki\u1ec3m so\u00e1t \u0111\u01b0\u1ee3c, th\u1eadm ch\u00ed \u0111\u1ebfn m\u1ee9c ng\u1ee7 g\u1eadt ngay c\u1ea3 khi \u0111ang l\u00e0m vi\u1ec7c ho\u1eb7c n\u00f3i chuy\u1ec7n. B\u00ean c\u1ea1nh \u0111\u00f3, ng\u01b0\u1eddi b\u1ec7nh c\u00f2n c\u00f3 th\u1ec3 tr\u1ea3i qua c\u00e1c c\u01a1n m\u1ed9ng kinh hoang t\u01b0\u1edfng v\u00e0o ban \u0111\u00eam v\u00e0 b\u1ecb t\u00ecnh tr\u1ea1ng m\u1ea5t c\u1ea3m gi\u00e1c v\u00e0 b\u1ea5t \u0111\u1ed9ng ng\u1eafn h\u1ea1n khi g\u1eb7p t\u00ecnh hu\u1ed1ng x\u00fac \u0111\u1ed9ng ho\u1eb7c c\u0103ng th\u1eb3ng.<\/p>\n

1.2. C\u01a1 ch\u1ebf b\u1ec7nh ch\u1ee9ng ng\u1ee7 r\u0169<\/h3>\n

C\u01a1 ch\u1ebf ch\u1ee9ng ng\u1ee7 r\u0169 (narcolepsy) ch\u01b0a \u0111\u01b0\u1ee3c hi\u1ec3u r\u00f5 ho\u00e0n to\u00e0n, nh\u01b0ng c\u00f3 m\u1ed9t s\u1ed1 nghi\u00ean c\u1ee9u cho th\u1ea5y r\u1eb1ng b\u1ec7nh n\u00e0y c\u00f3 th\u1ec3 li\u00ean quan \u0111\u1ebfn s\u1ef1 gi\u1ea3m b\u1edbt m\u1ed9t ch\u1ea5t g\u1ecdi l\u00e0 orexin (hay c\u00f2n g\u1ecdi l\u00e0 hypocretin).<\/p>\n

Orexin l\u00e0 m\u1ed9t ch\u1ea5t t\u1ea1o ra t\u1ea1i c\u00e1c t\u1ebf b\u00e0o th\u1ea7n kinh trong v\u00f9ng n\u00e3o g\u1ecdi l\u00e0 nucleus hypothalamicus. Ch\u1ea5t n\u00e0y c\u00f3 vai tr\u00f2 quan tr\u1ecdng trong vi\u1ec7c t\u0103ng c\u01b0\u1eddng s\u1ef1 t\u1ec9nh t\u00e1o v\u00e0 gi\u00fap duy tr\u00ec s\u1ef1 th\u1ee9c gi\u1ea5c. \u1ede nh\u1eefng ng\u01b0\u1eddi b\u1ecb ch\u1ee9ng ng\u1ee7 r\u0169, h\u1ecd c\u00f3 xu\u1ea5t hi\u1ec7n s\u1ef1 gi\u1ea3m b\u1edbt orexin, d\u1eabn \u0111\u1ebfn vi\u1ec7c gi\u1ea3m kh\u1ea3 n\u0103ng ki\u1ec3m so\u00e1t gi\u1ea5c ng\u1ee7 v\u00e0 th\u1ee9c gi\u1ea5c.<\/p>\n

Ngo\u00e0i ra, ch\u1ee9ng ng\u1ee7 r\u0169 c\u0169ng c\u00f3 th\u1ec3 li\u00ean quan \u0111\u1ebfn c\u00e1c v\u1ea5n \u0111\u1ec1 v\u1ec1 h\u1ec7 th\u1ed1ng th\u1ea7n kinh trung \u01b0\u01a1ng, bao g\u1ed3m c\u00e1c t\u1ebf b\u00e0o th\u1ea7n kinh v\u00e0 c\u00e1c ch\u1ea5t giao ti\u1ebfp th\u1ea7n kinh kh\u00e1c nh\u01b0 dopamine, serotonin v\u00e0 norepinephrine.<\/p>\n

Tuy nhi\u00ean, v\u1eabn c\u00f2n nhi\u1ec1u y\u1ebfu t\u1ed1 kh\u00e1c c\u00f3 th\u1ec3 g\u00f3p ph\u1ea7n v\u00e0o c\u01a1 ch\u1ebf c\u1ee7a ch\u1ee9ng ng\u1ee7 r\u0169 v\u00e0 c\u00e1c nh\u00e0 nghi\u00ean c\u1ee9u \u0111ang ti\u1ebfp t\u1ee5c nghi\u00ean c\u1ee9u \u0111\u1ec3 hi\u1ec3u r\u00f5 h\u01a1n v\u1ec1 b\u1ec7nh n\u00e0y.<\/p>\n

1.3. Ch\u1ee9ng ng\u1ee7 r\u0169 c\u00f3 \u0111i\u1ec1u tr\u1ecb ho\u00e0n to\u00e0n kh\u00f4ng?<\/h3>\n

\u0110\u1ec3 ch\u1ea9n \u0111o\u00e1n ch\u1ee9ng ng\u1ee7 r\u0169, b\u00e1c s\u0129 s\u1ebd th\u1ef1c hi\u1ec7n m\u1ed9t lo\u1ea1t c\u00e1c x\u00e9t nghi\u1ec7m gi\u1ea5c ng\u1ee7, bao g\u1ed3m th\u1eed nghi\u1ec7m gi\u1ea5c ng\u1ee7 ban ng\u00e0y v\u00e0 x\u00e9t nghi\u1ec7m gi\u1ea5c ng\u1ee7 qua \u0111\u00eam.<\/p>\n

Ch\u1ee9ng ng\u1ee7 r\u0169 kh\u00f4ng c\u00f3 ph\u01b0\u01a1ng ph\u00e1p \u0111i\u1ec1u tr\u1ecb ho\u00e0n to\u00e0n, nh\u01b0ng c\u00e1c bi\u1ec7n ph\u00e1p h\u1ed7 tr\u1ee3 nh\u01b0 s\u1eed d\u1ee5ng thu\u1ed1c gi\u00fap ng\u1ee7, thay \u0111\u1ed5i l\u1ed1i s\u1ed1ng, t\u1eadp luy\u1ec7n th\u1ec3 d\u1ee5c v\u00e0 t\u00e2m l\u00fd h\u1ecdc c\u00f3 th\u1ec3 gi\u00fap gi\u1ea3m thi\u1ec3u c\u00e1c tri\u1ec7u ch\u1ee9ng c\u1ee7a b\u1ec7nh. N\u1ebfu c\u1ea7n thi\u1ebft, b\u00e1c s\u0129 c\u00f3 th\u1ec3 k\u00ea \u0111\u01a1n thu\u1ed1c k\u00edch th\u00edch \u0111\u1ec3 gi\u00fap ng\u01b0\u1eddi b\u1ec7nh t\u1eadp trung v\u00e0 gi\u1eef t\u1ec9nh t\u00e1o trong su\u1ed1t ng\u00e0y.<\/p>\n

2. C\u00e1c thu\u1ed1c \u0111\u01b0\u1ee3c d\u00f9ng \u0111\u1ec3 tr\u1ecb ch\u1ee9ng ng\u1ee7 r\u0169<\/h2>\n

Hi\u1ec7n nay, c\u00f3 m\u1ed9t s\u1ed1 lo\u1ea1i thu\u1ed1c \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng \u0111\u1ec3 \u0111i\u1ec1u tr\u1ecb ch\u1ee9ng ng\u1ee7 r\u0169, c\u00e1c ho\u1ea1t ch\u1ea5t ph\u1ed5 bi\u1ebfn \u0111\u01b0\u1ee3c li\u1ec7t k\u00ea b\u00ean d\u01b0\u1edbi:<\/p>\n

    \n
  1. Modafinil: \u0110\u00e2y l\u00e0 m\u1ed9t lo\u1ea1i thu\u1ed1c k\u00edch th\u00edch \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng \u0111\u1ec3 gi\u00fap c\u1ea3i thi\u1ec7n s\u1ef1 t\u1ec9nh t\u00e1o v\u00e0 gi\u1ea3m c\u00e1c tri\u1ec7u ch\u1ee9ng c\u1ee7a ch\u1ee9ng ng\u1ee7 r\u0169. Modafinil t\u00e1c \u0111\u1ed9ng l\u00ean c\u00e1c h\u1ec7 th\u1ed1ng th\u1ea7n kinh trung \u01b0\u01a1ng v\u00e0 t\u0103ng s\u1ea3n xu\u1ea5t c\u00e1c ch\u1ea5t giao ti\u1ebfp th\u1ea7n kinh nh\u01b0 dopamine v\u00e0 norepinephrine.<\/li>\n
  2. Methylphenidate: \u0110\u00e2y l\u00e0 m\u1ed9t lo\u1ea1i thu\u1ed1c k\u00edch th\u00edch \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng \u0111\u1ec3 \u0111i\u1ec1u tr\u1ecb ch\u1ee9ng t\u0103ng \u0111\u1ed9ng gi\u1ea3m ch\u00fa \u00fd (ADHD), nh\u01b0ng c\u0169ng \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng \u0111\u1ec3 gi\u00fap ki\u1ec3m so\u00e1t c\u00e1c tri\u1ec7u ch\u1ee9ng c\u1ee7a ch\u1ee9ng ng\u1ee7 r\u0169. Methylphenidate t\u00e1c \u0111\u1ed9ng l\u00ean c\u00e1c h\u1ec7 th\u1ed1ng th\u1ea7n kinh trung \u01b0\u01a1ng v\u00e0 t\u0103ng s\u1ea3n xu\u1ea5t c\u00e1c ch\u1ea5t giao ti\u1ebfp th\u1ea7n kinh nh\u01b0 dopamine v\u00e0 norepinephrine.<\/li>\n
  3. Sodium oxybate: \u0110\u00e2y l\u00e0 m\u1ed9t lo\u1ea1i thu\u1ed1c \u0111\u01b0\u1ee3c ch\u1ec9 \u0111\u1ecbnh \u0111\u1ec3 \u0111i\u1ec1u tr\u1ecb ch\u1ee9ng ng\u1ee7 r\u0169. Thu\u1ed1c n\u00e0y t\u00e1c \u0111\u1ed9ng l\u00ean h\u1ec7 th\u1ea7n kinh trung \u01b0\u01a1ng v\u00e0 gi\u00fap c\u1ea3i thi\u1ec7n gi\u1ea5c ng\u1ee7 qua \u0111\u00eam, gi\u1ea3m b\u1edbt c\u00e1c c\u01a1n m\u1ed9ng kinh hoang t\u01b0\u1edfng v\u00e0 t\u0103ng c\u01b0\u1eddng s\u1ef1 t\u1ec9nh t\u00e1o v\u00e0o ban ng\u00e0y.<\/li>\n
  4. Antidepressants: M\u1ed9t s\u1ed1 lo\u1ea1i thu\u1ed1c antidepressants nh\u01b0 tricyclic antidepressants v\u00e0 selective serotonin reuptake inhibitors (SSRIs) c\u0169ng \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng \u0111\u1ec3 gi\u00fap gi\u1ea3m c\u00e1c tri\u1ec7u ch\u1ee9ng c\u1ee7a ch\u1ee9ng ng\u1ee7 r\u0169.<\/li>\n<\/ol>\n

    Tuy nhi\u00ean, vi\u1ec7c s\u1eed d\u1ee5ng c\u00e1c lo\u1ea1i thu\u1ed1c n\u00e0y ph\u1ea3i \u0111\u01b0\u1ee3c ch\u1ec9 \u0111\u1ecbnh v\u00e0 gi\u00e1m s\u00e1t ch\u1eb7t ch\u1ebd b\u1edfi b\u00e1c s\u0129 chuy\u00ean khoa \u0111\u1ec3 \u0111\u1ea3m b\u1ea3o hi\u1ec7u qu\u1ea3 \u0111i\u1ec1u tr\u1ecb v\u00e0 gi\u1ea3m thi\u1ec3u t\u00e1c d\u1ee5ng ph\u1ee5 c\u00f3 th\u1ec3 x\u1ea3y ra.<\/p>\n

    3. Lumryz – thu\u1ed1c m\u1edbi \u0111i\u1ec1u tr\u1ecb ch\u1ee9ng ng\u1ee7 r\u0169 \u0111\u01b0\u1ee3c FDA ch\u1ea5p thu\u1eadn<\/h2>\n

    C\u1ee5c Qu\u1ea3n l\u00fd Th\u1ef1c ph\u1ea9m & D\u01b0\u1ee3c ph\u1ea9m Hoa K\u1ef3 \u0111\u00e3 ph\u00ea duy\u1ec7t Lumryz \u0111\u1ec3 \u0111i\u1ec1u tr\u1ecb ch\u1ee9ng cataplexy ho\u1eb7c bu\u1ed3n ng\u1ee7 ban ng\u00e0y qu\u00e1 m\u1ee9c \u1edf ng\u01b0\u1eddi l\u1edbn m\u1eafc ch\u1ee9ng ng\u1ee7 r\u0169. Lumryz l\u00e0 m\u1ed9t c\u00f4ng th\u1ee9c gi\u1ea3i ph\u00f3ng k\u00e9o d\u00e0i c\u1ee7a natri oxybate \u0111\u01b0\u1ee3c u\u1ed1ng m\u1ed9t l\u1ea7n tr\u01b0\u1edbc khi \u0111i ng\u1ee7.<\/p>\n

    \"thuoc-lumryz-dieu-tri-chung-ngu-ru\"
    Thu\u1ed1c Lumryz \u0111i\u1ec1u tr\u1ecb ch\u1ee9ng ng\u1ee7 r\u0169 c\u00f3 ho\u1ea1t ch\u1ea5t Natri oxybate<\/figcaption><\/figure>\n

    3.1. Ho\u1ea1t ch\u1ea5t v\u00e0 c\u01a1 ch\u1ebf c\u1ee7a thu\u1ed1c Lumryz<\/h3>\n

    Lumryz ch\u1ee9a thu\u1ed1c \u1ee9c ch\u1ebf th\u1ea7n kinh trung \u01b0\u01a1ng natri oxybate, mu\u1ed1i natri c\u1ee7a gamma hydroxybutyrate (GHB) \u0111\u01b0\u1ee3c cho l\u00e0 c\u00f3 t\u00e1c d\u1ee5ng \u0111i\u1ec1u tr\u1ecb ch\u1ee9ng ng\u1ee7 r\u0169 th\u00f4ng qua c\u00e1c ho\u1ea1t \u0111\u1ed9ng c\u1ee7a GABAB t\u1ea1i c\u00e1c t\u1ebf b\u00e0o th\u1ea7n kinh noradrenergic v\u00e0 dopaminergic, c\u0169ng nh\u01b0 t\u1ea1i c\u00e1c t\u1ebf b\u00e0o th\u1ea7n kinh v\u00f9ng \u0111\u1ed3i th\u1ecb.<\/p>\n

    Natri oxybate l\u1ea7n \u0111\u1ea7u ti\u00ean \u0111\u01b0\u1ee3c ch\u1ea5p thu\u1eadn \u1edf d\u1ea1ng dung d\u1ecbch u\u1ed1ng d\u01b0\u1edbi t\u00ean th\u01b0\u01a1ng hi\u1ec7u Xyrem<\/a> v\u00e0o n\u0103m 2002. Xyrem \u0111\u01b0\u1ee3c d\u00f9ng l\u00e0m hai li\u1ec1u v\u00e0o ban \u0111\u00eam – li\u1ec1u \u0111\u1ea7u ti\u00ean tr\u01b0\u1edbc khi \u0111i ng\u1ee7 (hai gi\u1edd sau khi \u0103n) v\u00e0 li\u1ec1u th\u1ee9 hai sau \u0111\u00f3 2,5 \u0111\u1ebfn 4 gi\u1edd.<\/p>\n

    Lumryz l\u00e0 m\u1ed9t c\u00f4ng th\u1ee9c gi\u1ea3i ph\u00f3ng k\u00e9o d\u00e0i c\u1ee7a natri oxybate \u0111\u01b0\u1ee3c d\u00f9ng m\u1ed9t l\u1ea7n v\u00e0o ban \u0111\u00eam, hai gi\u1edd sau khi \u0103n.<\/p>\n

    Lumryz l\u00e0 ch\u1ea5t \u0111\u01b0\u1ee3c ki\u1ec3m so\u00e1t theo B\u1ea3ng III (nh\u1eefng thu\u1ed1c c\u00f3 kh\u1ea3 n\u0103ng l\u00e0m ng\u01b0\u1eddi b\u1ec7nh ph\u1ee5 thu\u1ed9c t\u1eeb m\u1ee9c \u0111\u1ed9 nh\u1eb9 \u0111\u1ebfn trung b\u00ecnh). Nh\u00e3n s\u1ea3n ph\u1ea9m cho Lumryz c\u00f3 c\u1ea3nh b\u00e1o v\u1ec1 suy nh\u01b0\u1ee3c h\u1ec7 th\u1ea7n kinh trung \u01b0\u01a1ng, l\u1ea1m d\u1ee5ng v\u00e0 s\u1eed d\u1ee5ng sai m\u1ee5c \u0111\u00edch \u0111i\u1ec1u tr\u1ecb ch\u1ee9ng ng\u1ee7 r\u0169.<\/p>\n

    3.2. T\u00e1c d\u1ee5ng ph\u1ee5 c\u1ee7a Lumryz<\/h3>\n

    Lumryz ch\u1ec9 kh\u1ea3 d\u1ee5ng th\u00f4ng qua m\u1ed9t ch\u01b0\u01a1ng tr\u00ecnh h\u1ea1n ch\u1ebf c\u00f3 t\u00ean l\u00e0 Lumryz REMS.
    \nC\u00e1c c\u1ea3nh b\u00e1o v\u00e0 bi\u1ec7n ph\u00e1p ph\u00f2ng ng\u1eeba li\u00ean quan \u0111\u1ebfn Lumryz bao g\u1ed3m suy nh\u01b0\u1ee3c h\u1ec7 th\u1ed1ng th\u1ea7n kinh trung \u01b0\u01a1ng; tr\u1ea7m c\u1ea3m v\u00e0 t\u1ef1 t\u1eed; nh\u1ea7m l\u1eabn \/ lo l\u1eafng; v\u00e0 c\u00e1c r\u1ed1i lo\u1ea1n li\u00ean quan \u0111\u1ebfn gi\u1ea5c ng\u1ee7 g\u00e2y r\u1ed1i. Lumryz c\u0169ng c\u00f3 h\u00e0m l\u01b0\u1ee3ng natri cao.<\/p>\n

    C\u00e1c ph\u1ea3n \u1ee9ng b\u1ea5t l\u1ee3i th\u01b0\u1eddng g\u1eb7p bao g\u1ed3m bu\u1ed3n n\u00f4n, ch\u00f3ng m\u1eb7t, \u0111\u00e1i d\u1ea7m, nh\u1ee9c \u0111\u1ea7u v\u00e0 n\u00f4n<\/p>\n","protected":false},"excerpt":{"rendered":"

    Ch\u1ee9ng ng\u1ee7 r\u0169 l\u00e0 m\u1ed9t r\u1ed1i lo\u1ea1n gi\u1ea5c ng\u1ee7 g\u00e2y ra s\u1ef1 m\u1ea5t ki\u1ec3m so\u00e1t gi\u1ea5c ng\u1ee7 v\u00e0o ban ng\u00e0y v\u00e0 c\u00e1c c\u01a1n m\u1ed9ng kinh hoang t\u01b0\u1edfng v\u00e0o ban \u0111\u00eam. \u0110\u00e2y l\u00e0 m\u1ed9t b\u1ec7nh r\u1ea5t kh\u00f3 ch\u1ecbu v\u00e0 \u1ea3nh h\u01b0\u1edfng \u0111\u1ebfn ch\u1ea5t l\u01b0\u1ee3ng cu\u1ed9c s\u1ed1ng c\u1ee7a ng\u01b0\u1eddi b\u1ec7nh. Natri oxybate l\u00e0 m\u1ed9t trong nh\u1eefng ho\u1ea1t […]<\/p>\n","protected":false},"author":56,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[12],"tags":[],"yoast_head":"\nThu\u1ed1c m\u1edbi \u0111i\u1ec1u tr\u1ecb ch\u1ee9ng ng\u1ee7 r\u0169 - Lumryz \u0111\u01b0\u1ee3c FDA ch\u1ea5p thu\u1eadn - Vinmec<\/title>\n<meta name=\"description\" content=\"Lumryz l\u00e0 thu\u1ed1c m\u1edbi v\u1edbi ti\u1ec7n \u00edch gi\u1ea3m s\u1ed1 l\u1ea7n d\u00f9ng xu\u1ed1ng 1 l\u1ea7n m\u1ed7i ng\u00e0y, gi\u00fap c\u1ea3i thi\u1ec7n ch\u1ea5t l\u01b0\u1ee3ng cu\u1ed9c s\u1ed1ng c\u1ee7a b\u1ec7nh nh\u00e2n ch\u1ee9ng ng\u1ee7 r\u0169.\" \/>\n<meta name=\"robots\" content=\"noindex, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Thu\u1ed1c m\u1edbi \u0111i\u1ec1u tr\u1ecb ch\u1ee9ng ng\u1ee7 r\u0169 - 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