{"id":32002,"date":"2023-05-09T03:09:49","date_gmt":"2023-05-08T20:09:49","guid":{"rendered":"http:\/\/noithathoaphat.in\/ctv\/?p=32002"},"modified":"2023-05-09T03:09:49","modified_gmt":"2023-05-08T20:09:49","slug":"thuoc-khang-sinh-chong-ung-thu","status":"publish","type":"post","link":"http:\/\/noithathoaphat.in\/ctv\/index.php\/2023\/05\/09\/thuoc-khang-sinh-chong-ung-thu\/","title":{"rendered":"Thu\u1ed1c kh\u00e1ng sinh ch\u1ed1ng Ung th\u01b0"},"content":{"rendered":"

C\u00f3 h\u00e0ng tr\u0103m lo\u1ea1i thu\u1ed1c kh\u00e1ng sinh \u0111\u01b0\u1ee3c k\u00ea \u0111\u01a1n ng\u00e0y h\u00f4m nay. M\u1ed9t s\u1ed1 \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng \u0111\u1ec3 ch\u1ed1ng ung th\u01b0 k\u1ebft h\u1ee3p v\u1edbi c\u00e1c h\u00ecnh th\u1ee9c \u0111i\u1ec1u tr\u1ecb kh\u00e1c nh\u01b0 x\u1ea1 tr\u1ecb, tr\u1ecb li\u1ec7u mi\u1ec5n d\u1ecbch v\u00e0 h\u00f3a tr\u1ecb. M\u1eddi tham kh\u1ea3o b\u00e0i \u0111\u1ecdc b\u00ean d\u01b0\u1edbi \u0111\u1ec3 c\u00f3 th\u00eam th\u00f4ng tin v\u1ec1 c\u00e1c lo\u1ea1i thu\u1ed1c kh\u00e1ng sinh s\u1eed d\u1ee5ng \u0111i\u1ec1u tr\u1ecb Ung th\u01b0.<\/span><\/p>\n

1. Gi\u1edbi thi\u1ec7u<\/span><\/h2>\n

Kh\u00e1ng sinh ch\u1ed1ng ung th\u01b0 \u0111\u00e3 \u0111\u01b0\u1ee3c t\u00ecm th\u1ea5y trong c\u00e1c nghi\u00ean c\u1ee9u nh\u1eb1m th\u00fac \u0111\u1ea9y ch\u1ebft t\u1ebf b\u00e0o ung th\u01b0, c\u1ed9ng v\u1edbi vi\u1ec7c ng\u0103n ch\u1eb7n s\u1ef1 l\u00e2y lan c\u1ee7a c\u00e1c t\u1ebf b\u00e0o ung th\u01b0 tr\u00ean kh\u1eafp c\u01a1 th\u1ec3 (di c\u0103n). M\u1ed9t s\u1ed1 kh\u00e1ng sinh c\u0169ng \u0111\u00e3 \u0111\u01b0\u1ee3c ch\u1ee9ng minh l\u00e0 t\u0103ng c\u01b0\u1eddng h\u1ec7 th\u1ed1ng mi\u1ec5n d\u1ecbch, l\u00e0m cho c\u00e1c ph\u01b0\u01a1ng ph\u00e1p \u0111i\u1ec1u tr\u1ecb nh\u01b0 b\u1ee9c x\u1ea1 hi\u1ec7u qu\u1ea3 h\u01a1n. Nh\u1eefng ph\u00e1t hi\u1ec7n n\u00e0y r\u1ea5t t\u00edch c\u1ef1c.\u00a0<\/span><\/p>\n

Tuy nhi\u00ean, kh\u00e1ng sinh c\u0169ng \u0111\u01b0\u1ee3c cho l\u00e0\u00a0 c\u00f3 t\u00e1c \u0111\u1ed9ng ti\u00eau c\u1ef1c \u0111\u1ebfn s\u1ef1 t\u0103ng tr\u01b0\u1edfng v\u00e0 \u1ea3nh h\u01b0\u1edfng \u0111\u1ebfn qu\u00e1 tr\u00ecnh \u0111i\u1ec1u tr\u1ecb ung th\u01b0. Tr\u00ean th\u1ef1c t\u1ebf, kh\u00e1ng sinh ph\u1ed5 r\u1ed9ng \u0111\u00e3 \u0111\u01b0\u1ee3c cho th\u1ea5y l\u00e0m gi\u1ea3m t\u1ef7 l\u1ec7 s\u1ed1ng s\u00f3t chung \u1edf m\u1ed9t s\u1ed1 b\u1ec7nh nh\u00e2n ung th\u01b0 \u0111\u01b0\u1ee3c \u0111i\u1ec1u tr\u1ecb b\u1eb1ng li\u1ec7u ph\u00e1p mi\u1ec5n d\u1ecbch. M\u1ed9t nghi\u00ean c\u1ee9u \u0111\u00e3 ph\u00e2n t\u00edch vi\u1ec7c s\u1eed d\u1ee5ng kh\u00e1ng sinh theo quy \u0111\u1ecbnh trong qu\u00e1 tr\u00ecnh h\u00f3a tr\u1ecb li\u1ec7u c\u0169ng cho k\u1ebft qu\u1ea3 t\u01b0\u01a1ng t\u1ef1. Kh\u00e1ng sinh l\u00e0m thay \u0111\u1ed5i h\u1ec7 vi sinh v\u1eadt \u0111\u01b0\u1eddng ru\u1ed9t b\u1eb1ng c\u00e1ch ti\u00eau di\u1ec7t vi khu\u1ea9n t\u1ed1t c\u0169ng nh\u01b0 x\u1ea5u. S\u1ef1 gi\u00e1n \u0111o\u1ea1n n\u00e0y c\u1ee7a h\u1ec7 vi sinh v\u1eadt \u0111\u01b0\u1eddng ru\u1ed9t c\u00f3 th\u1ec3 l\u00e0m gi\u1ea3m kh\u1ea3 n\u0103ng ch\u1ed1ng ung th\u01b0 c\u1ee7a c\u01a1 th\u1ec3, c\u1ed9ng v\u1edbi vi\u1ec7c t\u0103ng vi\u00eam. Vi\u00eam th\u01b0\u1eddng li\u00ean quan \u0111\u1ebfn s\u1ef1 ph\u00e1t tri\u1ec3n v\u00e0 ti\u1ebfn tri\u1ec3n ung th\u01b0. \u0110i\u1ec1u tr\u1ecb ung th\u01b0, c\u00f3 ho\u1eb7c kh\u00f4ng c\u00f3 kh\u00e1ng sinh, c\u00f3 th\u1ec3 ph\u1ee9c t\u1ea1p c\u00f2n ph\u1ea3i ph\u1ee5 thu\u1ed9c v\u00e0o lo\u1ea1i v\u00e0 giai \u0111o\u1ea1n ung th\u01b0 \u0111\u01b0\u1ee3c \u0111i\u1ec1u tr\u1ecb.<\/span><\/p>\n

2. C\u00e1c lo\u1ea1i thu\u1ed1c kh\u00e1ng sinh \u0111i\u1ec1u tr\u1ecb Ung th\u01b0<\/span><\/h2>\n

\u0110\u00e2y l\u00e0 m\u1ed9t s\u1ed1 lo\u1ea1i kh\u00e1ng sinh m\u00e0 b\u00e1c s\u0129 c\u00f3 th\u1ec3 c\u00e2n nh\u1eafc b\u1ed5 sung trong qu\u00e1 tr\u00ecnh \u0111i\u1ec1u tr\u1ecb b\u1ec7nh nh\u00e2n.<\/span><\/p>\n

Doxorubicin<\/strong><\/p>\n

\"Doxorubicin\"
Doxorubicin<\/figcaption><\/figure>\n

Doxorubicin c\u0169ng \u0111\u01b0\u1ee3c g\u1ecdi l\u00e0 adriamycin –\u00a0 m\u1ed9t lo\u1ea1i kh\u00e1ng sinh ch\u1ed1ng ung th\u01b0 anthracycline \u0111\u1ebfn t\u1eeb vi khu\u1ea9n Streptomyces Peucetius. N\u00f3 ho\u1ea1t \u0111\u1ed9ng b\u1eb1ng c\u00e1ch l\u00e0m h\u1ecfng DNA t\u1ebf b\u00e0o v\u00e0 ti\u00eau di\u1ec7t c\u00e1c t\u1ebf b\u00e0o ung th\u01b0 \u0111\u1ed3ng th\u1eddi ng\u0103n ch\u1eb7n m\u1ed9t s\u1ed1 enzyme c\u1ea7n thi\u1ebft \u0111\u1ec3 s\u1eeda ch\u1eefa v\u00e0 ph\u00e2n chia t\u1ebf b\u00e0o.\u00a0<\/span><\/p>\n

Doxorubicin c\u00f3 m\u1ed9t s\u1ed1 t\u00ean bi\u1ec7t d\u01b0\u1ee3c th\u01b0\u1eddng g\u1eb7p nh\u01b0 Lipodox v\u00e0 Doxil.<\/span><\/p>\n

Thu\u1ed1c n\u00e0y \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng \u0111\u1ec3 \u0111i\u1ec1u tr\u1ecb m\u1ed9t s\u1ed1 lo\u1ea1i ung th\u01b0:\u00a0<\/span><\/p>\n

    \n
  • Ung th\u01b0 h\u1ea1ch<\/span><\/li>\n
  • Ung th\u01b0 h\u1ea1ch b\u1ea1ch huy\u1ebft<\/span><\/li>\n
  • Ung th\u01b0 v\u00fa ung th\u01b0 v\u00fa\u00a0<\/span><\/li>\n<\/ul>\n

    Bleomycin<\/strong><\/p>\n

    \"Bleomycin\u00a0\"
    Bleomycin<\/figcaption><\/figure>\n

    Bleomycin l\u00e0 m\u1ed9t lo\u1ea1i kh\u00e1ng sinh \u0111\u01b0\u1ee3c FDA ch\u1ea5p thu\u1eadn \u0111\u1ec3 \u0111i\u1ec1u tr\u1ecb m\u1ed9t s\u1ed1 lo\u1ea1i ung th\u01b0 v\u00e0o n\u0103m 1975, lo\u1ea1i thu\u1ed1c n\u00e0y \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng trong h\u00f3a tr\u1ecb. Bleomycin \u0111\u01b0\u1ee3c ch\u1ee9ng minh l\u00e0 c\u00f3 hi\u1ec7u qu\u1ea3 cao \u0111\u1ec3 \u0111i\u1ec1u tr\u1ecb ung th\u01b0 \u0111\u1ea7u v\u00e0 c\u1ed5 kh\u00f4ng ph\u1ea3i l\u00e0 ung th\u01b0 t\u1ebf b\u00e0o h\u1eafc t\u1ed1.\u00a0<\/span><\/p>\n

    Bleomycin \u0111\u1ebfn t\u1eeb vi khu\u1ea9n streptomyces verticillus. Bleomycin ng\u0103n ch\u1eb7n s\u1ef1 ph\u00e1t tri\u1ec3n c\u1ee7a t\u1ebf b\u00e0o ung th\u01b0 b\u1eb1ng c\u00e1ch li\u00ean k\u1ebft v\u1edbi DNA v\u00e0 ph\u00e1 v\u1ee1 c\u00e1c chu\u1ed7i c\u1ee7a n\u00f3.\u00a0<\/span><\/p>\n

    T\u00ean bi\u1ec7t d\u01b0\u1ee3c c\u1ee7a Bleomycin l\u00e0 Blenoxane.\u00a0<\/span><\/p>\n

    Bleomycin \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng \u0111\u1ec3 \u0111i\u1ec1u tr\u1ecb:<\/span><\/p>\n

      \n
    • Ung th\u01b0 bi\u1ec3u m\u00f4 t\u1ebf b\u00e0o v\u1ea3y<\/span><\/li>\n
    • Ung th\u01b0 tinh ho\u00e0n<\/span><\/li>\n
    • Ung th\u01b0 gan<\/span><\/li>\n<\/ul>\n

      Daunorubicin<\/strong><\/p>\n

      \"Daunorubicin\u00a0\"
      Daunorubicin<\/figcaption><\/figure>\n

      Daunorubicin l\u00e0 m\u1ed9t lo\u1ea1i kh\u00e1ng sinh anthracycline \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng c\u00f9ng v\u1edbi c\u00e1c lo\u1ea1i thu\u1ed1c kh\u00e1c nh\u01b0 m\u1ed9t lo\u1ea1i thu\u1ed1c ch\u1ed1ng ung th\u01b0 \u0111\u1ea7u ti\u00ean trong qu\u00e1 tr\u00ecnh \u0111i\u1ec1u tr\u1ecb c\u1ea3m \u1ee9ng thuy\u00ean gi\u1ea3m.\u00a0<\/span><\/p>\n

      Daunorubicin \u0111\u1ebfn t\u1eeb vi khu\u1ea9n Streptomyces coeruleorubidus. Kh\u00e1ng sinh n\u00e0y \u1ee9c ch\u1ebf ti\u00eau di\u1ec7t c\u00e1c t\u1ebf b\u00e0o ung th\u01b0 b\u1eb1ng c\u00e1ch ch\u1eb7n m\u1ed9t enzyme c\u1ea7n thi\u1ebft \u0111\u1ec3 ph\u00e2n chia t\u1ebf b\u00e0o v\u00e0 s\u1eeda ch\u1eefa DNA.\u00a0<\/span><\/p>\n

      T\u00ean bi\u1ec7t d\u01b0\u1ee3c c\u1ee7a Daunorubicin l\u00e0 Cerubidine.\u00a0<\/span><\/p>\n

      Thu\u1ed1c n\u00e0y \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng \u0111\u1ec3 \u0111i\u1ec1u tr\u1ecb\u00a0<\/span><\/p>\n

        \n
      • Ung th\u01b0 b\u1ea1ch c\u1ea7u c\u1ea5p t\u00ednh\u00a0<\/span><\/li>\n
      • Ung th\u01b0 b\u1ea1ch c\u1ea7u lymphocytic<\/span><\/li>\n<\/ul>\n

        Mitomycin<\/strong><\/p>\n

        \"Mitomycin\u00a0\"
        Mitomycin<\/figcaption><\/figure>\n

        Mitomycin l\u00e0 m\u1ed9t lo\u1ea1i kh\u00e1ng sinh ch\u1ed1ng ung th\u01b0. Lo\u1ea1i kh\u00e1ng sinh ch\u1ed1ng ung th\u01b0 n\u00e0y ho\u1ea1t \u0111\u1ed9ng b\u1eb1ng c\u00e1ch can thi\u1ec7p v\u00e0o ADN t\u1ebf b\u00e0o v\u00e0 ng\u0103n ch\u1eb7n s\u1ef1 ph\u00e1t tri\u1ec3n c\u1ee7a t\u1ebf b\u00e0o. Mitomycin c\u0169ng l\u00e0 m\u1ed9t t\u00e1c nh\u00e2n ki\u1ec1m h\u00f3a. C\u00e1c t\u00e1c nh\u00e2n ki\u1ec1m h\u00f3a ng\u0103n ch\u1eb7n c\u00e1c chu\u1ed7i DNA li\u00ean k\u1ebft v\u1edbi nhau d\u1eabn \u0111\u1ebfn ph\u00e1 v\u1ee1 c\u00e1c chu\u1ed7i DNA v\u00e0 ng\u0103n ch\u1eb7n c\u00e1c t\u1ebf b\u00e0o ung th\u01b0 ph\u00e1t tri\u1ec3n. Mitomycin \u0111\u1ebfn t\u1eeb vi khu\u1ea9n streptomyces.\u00a0<\/span><\/p>\n

        T\u00ean bi\u1ec7t d\u01b0\u1ee3c c\u1ee7a Mitomycin l\u00e0 Jelmyto.\u00a0<\/span><\/p>\n

        Thu\u1ed1c n\u00e0y \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng \u0111\u1ec3 \u0111i\u1ec1u tr\u1ecb\u00a0<\/span><\/p>\n

          \n
        • Ung th\u01b0 d\u1ea1 d\u00e0y\u00a0<\/span><\/li>\n
        • Ung th\u01b0 tuy\u1ebfn t\u1ee5y\u00a0<\/span><\/li>\n
        • Ung th\u01b0 \u0111\u01b0\u1eddng ti\u1ebft ni\u1ec7u tr\u00ean m\u1ee9c \u0111\u1ed9 th\u1ea5p<\/span><\/li>\n<\/ul>\n

          Plicamycin<\/strong><\/p>\n

          \"Plicamycin\"
          Plicamycin<\/figcaption><\/figure>\n

          Plicamycin l\u00e0 m\u1ed9t lo\u1ea1i kh\u00e1ng sinh ch\u1ed1ng ung th\u01b0 \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng trong c\u00e1c b\u1ec7nh nh\u00e2n ung th\u01b0 nh\u1eadp vi\u1ec7n \u0111\u01b0\u1ee3c c\u00e2n nh\u1eafc kh\u00f4ng c\u1ea7n ph\u1eabu thu\u1eadt ho\u1eb7c ph\u00f3ng x\u1ea1.\u00a0<\/span><\/p>\n

          Plicamycin \u0111\u1ebfn t\u1eeb vi khu\u1ea9n streptomyces plicatus. N\u00f3 ho\u1ea1t \u0111\u1ed9ng b\u1eb1ng c\u00e1ch li\u00ean k\u1ebft v\u1edbi DNA t\u1ebf b\u00e0o, ng\u0103n ch\u00fang t\u1ea1o ra protein v\u00e0 RNA. Thu\u1ed1c n\u00e0y c\u00f3 th\u1ec3 g\u00e2y ra t\u00e1c d\u1ee5ng ph\u1ee5 nghi\u00eam tr\u1ecdng v\u00e0 kh\u00f4ng \u0111\u01b0\u1ee3c thi\u1ebft k\u1ebf \u0111\u1ec3 \u0111i\u1ec1u tr\u1ecb ung th\u01b0 di\u1ec7n r\u1ed9ng.\u00a0<\/span><\/p>\n

          T\u00ean bi\u1ec7t d\u01b0\u1ee3c c\u1ee7a Plicamycin l\u00e0 Mithracin.\u00a0<\/span><\/p>\n

          Thu\u1ed1c n\u00e0y \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng \u0111\u1ec3 \u0111i\u1ec1u tr\u1ecb:<\/span><\/p>\n

            \n
          • Ung th\u01b0 tinh ho\u00e0n\u00a0<\/span><\/li>\n<\/ul>\n

            3. K\u1ebft lu\u1eadn<\/span><\/h2>\n

            Thu\u1ed1c kh\u00e1ng sinh \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng trong \u0111i\u1ec1u tr\u1ecb ung th\u01b0 v\u00e0 th\u01b0\u1eddng \u0111\u01b0\u1ee3c k\u1ebft h\u1ee3p v\u1edbi c\u00e1c ph\u01b0\u01a1ng ph\u00e1p \u0111i\u1ec1u tr\u1ecb kh\u00e1c nh\u01b0 (h\u00f3a tr\u1ecb li\u1ec7u mi\u1ec5n d\u1ecbch x\u1ea1 tr\u1ecb,..). Ngo\u00e0i m\u1ed9t s\u1ed1 lo\u1ea1i thu\u1ed1c k\u1ec3 tr\u00ean, c\u00f2n nhi\u1ec1u lo\u1ea1i thu\u1ed1c kh\u00e1ng sinh kh\u00e1c c\u00f3 th\u1ec3 \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng trong qu\u00e1 tr\u00ecnh \u0111i\u1ec1u tr\u1ecb b\u1ec7nh. N\u00ean c\u00e2n nh\u1eafc s\u1eed d\u1ee5ng kh\u00e1ng sinh b\u1edfi n\u1ebfu s\u1eed d\u1ee5ng\u00a0 kh\u00f4ng h\u1ee3p l\u00fd v\u00e0 qu\u00e1 m\u1ee9c c\u00f3 th\u1ec3 d\u1eabn \u0111\u1ebfn nhi\u1ec1u t\u00e1c \u0111\u1ed9ng kh\u00f4ng mong mu\u1ed1n, bao g\u1ed3m c\u1ea3 vi\u1ec7c t\u0103ng s\u1ef1 kh\u00e1ng c\u1ef1 c\u1ee7a vi khu\u1ea9n v\u1edbi kh\u00e1ng sinh. \u0110i\u1ec1u n\u00e0y d\u1eabn \u0111\u1ebfn nguy c\u01a1 cao v\u1ec1 s\u1ef1 ph\u00e1t tri\u1ec3n c\u1ee7a c\u00e1c ch\u1ee7ng vi khu\u1ea9n kh\u00e1ng kh\u00e1ng sinh.<\/span><\/p>\n

            V\u00ec \u0111i\u1ec1u n\u00e0y, s\u1eed d\u1ee5ng kh\u00e1ng sinh \u0111\u1ec3 ch\u1ed1ng ung th\u01b0 c\u1ea7n \u0111\u01b0\u1ee3c th\u1ef1c hi\u1ec7n m\u1ed9t c\u00e1ch c\u00e2n nh\u1eafc v\u00e0 ch\u1ec9 \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng khi c\u1ea7n thi\u1ebft v\u00e0 \u0111\u01b0\u1ee3c ch\u1ec9 \u0111\u1ecbnh b\u1edfi b\u00e1c s\u0129 chuy\u00ean m\u00f4n \u0111\u1ec3 t\u00ecm ra lo\u1ea1i thu\u1ed1c h\u1ee3p l\u00fd, ph\u00f9 h\u1ee3p v\u1edbi lo\u1ea1i v\u00e0 giai \u0111o\u1ea1n b\u1ec7nh Ung th\u01b0.<\/span><\/p>\n

            Ngu\u1ed3n Healthline<\/span><\/p>\n","protected":false},"excerpt":{"rendered":"

            C\u00f3 h\u00e0ng tr\u0103m lo\u1ea1i thu\u1ed1c kh\u00e1ng sinh \u0111\u01b0\u1ee3c k\u00ea \u0111\u01a1n ng\u00e0y h\u00f4m nay. M\u1ed9t s\u1ed1 \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng \u0111\u1ec3 ch\u1ed1ng ung th\u01b0 k\u1ebft h\u1ee3p v\u1edbi c\u00e1c h\u00ecnh th\u1ee9c \u0111i\u1ec1u tr\u1ecb kh\u00e1c nh\u01b0 x\u1ea1 tr\u1ecb, tr\u1ecb li\u1ec7u mi\u1ec5n d\u1ecbch v\u00e0 h\u00f3a tr\u1ecb. M\u1eddi tham kh\u1ea3o b\u00e0i \u0111\u1ecdc b\u00ean d\u01b0\u1edbi \u0111\u1ec3 c\u00f3 th\u00eam th\u00f4ng tin v\u1ec1 c\u00e1c […]<\/p>\n","protected":false},"author":57,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[6,33],"tags":[],"yoast_head":"\nThu\u1ed1c kh\u00e1ng sinh ch\u1ed1ng Ung th\u01b0 - Vinmec<\/title>\n<meta name=\"description\" content=\"thu\u1ed1c kh\u00e1ng sinh \u0111i\u1ec1u tr\u1ecb ung th\u01b0 c\u00f3 th\u1ec3 k\u1ebft h\u1ee3p v\u1edbi c\u00e1c h\u00ecnh th\u1ee9c \u0111i\u1ec1u tr\u1ecb kh\u00e1c nh\u01b0 x\u1ea1 tr\u1ecb, tr\u1ecb li\u1ec7u mi\u1ec5n d\u1ecbch v\u00e0 h\u00f3a tr\u1ecb\" \/>\n<meta name=\"robots\" content=\"noindex, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Thu\u1ed1c kh\u00e1ng sinh ch\u1ed1ng Ung th\u01b0 - 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