{"id":31755,"date":"2023-05-06T17:17:30","date_gmt":"2023-05-06T10:17:30","guid":{"rendered":"http:\/\/noithathoaphat.in\/ctv\/?p=31755"},"modified":"2023-05-07T09:45:48","modified_gmt":"2023-05-07T02:45:48","slug":"dai-thuc-bao-vai-tro-trong-phan-ung-viem-man","status":"publish","type":"post","link":"http:\/\/noithathoaphat.in\/ctv\/index.php\/2023\/05\/06\/dai-thuc-bao-vai-tro-trong-phan-ung-viem-man\/","title":{"rendered":"\u0110\u1ea1i th\u1ef1c b\u00e0o: Vai tr\u00f2 trong ph\u1ea3n \u1ee9ng vi\u00eam m\u1ea1n"},"content":{"rendered":"

\u0110\u1ea1i th\u1ef1c b\u00e0o (Macrophages) l\u00e0 lo\u1ea1i t\u1ebf b\u00e0o mi\u1ec5n d\u1ecbch quan tr\u1ecdng trong qu\u00e1 tr\u00ecnh ph\u1ea3n \u1ee9ng vi\u00eam c\u1ea5p t\u00ednh. Trong tr\u01b0\u1eddng h\u1ee3p n\u00e0y, ch\u00fang ph\u1ea3n \u1ee9ng v\u1edbi c\u00e1c t\u00e1c nh\u00e2n g\u00e2y vi\u00eam b\u1eb1ng c\u00e1ch ti\u1ebft ra c\u00e1c ch\u1ea5t g\u00e2y vi\u00eam nh\u01b0 cytokines v\u00e0 chemokines, \u0111\u1ed3ng th\u1eddi k\u00edch ho\u1ea1t c\u00e1c t\u1ebf b\u00e0o kh\u00e1c \u0111\u1ec3 di chuy\u1ec3n \u0111\u1ebfn v\u00f9ng b\u1ecb t\u1ed5n th\u01b0\u01a1ng.<\/strong><\/p>\n

1. Gi\u1edbi thi\u1ec7u<\/h2>\n

\u0110\u1ea1i th\u1ef1c b\u00e0o, l\u00e0 m\u1ed9t lo\u1ea1i t\u1ebf b\u00e0o mi\u1ec5n d\u1ecbch quan tr\u1ecdng trong vi\u00eam c\u1ea5p v\u00e0 vi\u00eam m\u00e3n t\u00ednh. Trong b\u00e0i vi\u1ebft n\u00e0y, ch\u00fang ta s\u1ebd t\u1eadp trung v\u00e0o vai tr\u00f2 c\u1ee7a \u0111\u1ea1i th\u1ef1c b\u00e0o trong vi\u00eam m\u1ea1n, bao g\u1ed3m tr\u00ecnh di\u1ec7n kh\u00e1ng nguy\u00ean t\u1ea1i ch\u1ed7 (local antigen presentation), b\u00e0i ti\u1ebft cytokine v\u00e0 c\u00f3 th\u1ec3 h\u00ecnh th\u00e0nh u h\u1ea1t (granuloma formation).<\/p>\n

Vi\u00eam c\u1ea5p t\u00ednh l\u00e0 ph\u1ea3n \u1ee9ng nhanh di\u1ec5n ra trong v\u00f2ng 2-3 ng\u00e0y c\u1ee7a c\u01a1 th\u1ec3 v\u1edbi ch\u1ea5n th\u01b0\u01a1ng ho\u1eb7c nhi\u1ec5m tr\u00f9ng. \u0110\u1ea1i th\u1ef1c b\u00e0o l\u00e0 m\u1ed9t trong nh\u1eefng t\u1ebf b\u00e0o mi\u1ec5n d\u1ecbch \u0111\u1ea7u ti\u00ean \u0111\u1ebfn \u0111\u1ecba \u0111i\u1ec3m vi\u00eam. Khi \u0111\u1ebfn \u0111\u00f3, ch\u00fang ti\u1ebfn h\u00e0nh th\u1ef1c b\u00e0o v\u00e0 ti\u00eau di\u1ec7t t\u00e1c nh\u00e2n g\u00e2y b\u1ec7nh, b\u1eb1ng c\u01a1 ch\u1ebf ti\u00eau di\u1ec7t kh\u00f4ng ph\u1ee5 thu\u1ed9c v\u00e0o O2 (O2-independent Killing). Ch\u00fang c\u0169ng b\u00e0i ti\u1ebft cytokine \u0111\u1ec3 k\u00edch ho\u1ea1t t\u1ebf b\u00e0o mi\u1ec5n d\u1ecbch kh\u00e1c \u0111\u1ebfn \u0111\u1ecba \u0111i\u1ec3m vi\u00eam. Trong m\u1ed9t s\u1ed1 tr\u01b0\u1eddng h\u1ee3p, h\u00ecnh th\u00e0nh \u00e1p xe (abscess formation) c\u00f3 th\u1ec3 x\u1ea3y ra, \u0111\u00f3 l\u00e0 s\u1ef1 t\u00edch t\u1ee5 c\u1ee7a nhi\u1ec5m tr\u00f9ng v\u00e0 neutrophils \u0111\u01b0\u1ee3c bao quanh b\u1edfi c\u00e1c nguy\u00ean b\u00e0o s\u1ee3i. C\u00e1c \u0111\u1ed9c gi\u1ea3 c\u00f3 th\u1ec3 truy c\u1eadp v\u00e0o trang web vinmecdr.com<\/a>, \u0111\u1ec3 tham kh\u1ea3o chi ti\u1ebft vai tr\u00f2 \u0111\u1ea1i th\u1ef1c b\u00e0o trong ph\u1ea3n \u1ee9ng vi\u00eam c\u1ea5p.<\/p>\n

Vi\u00eam m\u00e3n t\u00ednh l\u00e0 m\u1ed9t tr\u1ea1ng th\u00e1i vi\u00eam k\u00e9o d\u00e0i trong th\u1eddi gian d\u00e0i, th\u01b0\u1eddng l\u00e0 t\u1eeb v\u00e0i tu\u1ea7n \u0111\u1ebfn v\u00e0i th\u00e1ng ho\u1eb7c th\u1eadm ch\u00ed nhi\u1ec1u n\u0103m. Tr\u1ea1ng th\u00e1i n\u00e0y th\u01b0\u1eddng xu\u1ea5t hi\u1ec7n khi c\u01a1 th\u1ec3 kh\u00f4ng th\u1ec3 lo\u1ea1i b\u1ecf \u0111\u01b0\u1ee3c t\u00e1c nh\u00e2n g\u00e2y vi\u00eam ho\u1eb7c khi c\u00e1c t\u1ebf b\u00e0o mi\u1ec5n d\u1ecbch v\u00e0 ph\u1ea3n \u1ee9ng vi\u00eam kh\u00f4ng ho\u1ea1t \u0111\u1ed9ng \u0111\u00fang c\u00e1ch, d\u1eabn \u0111\u1ebfn s\u1ef1 t\u1ed5n th\u01b0\u01a1ng m\u00f4 v\u00e0 t\u1ebf b\u00e0o. Trong vi\u00eam m\u00e3n t\u00ednh, \u0111\u1ea1i th\u1ef1c b\u00e0o c\u00f3 vai tr\u00f2 quan tr\u1ecdng trong nhi\u1ec1u kh\u00eda c\u1ea1nh c\u1ee7a qu\u00e1 tr\u00ecnh vi\u00eam bao g\u1ed3m tr\u00ecnh b\u00e0y kh\u00e1ng nguy\u00ean t\u1ea1i ch\u1ed7, s\u1ea3n xu\u1ea5t cytokine v\u00e0 h\u00ecnh th\u00e0nh u h\u1ea1t. Ngo\u00e0i ra, c\u00e1c t\u1ebf b\u00e0o mi\u1ec5n d\u1ecbch kh\u00e1c nh\u01b0 lymphocyte c\u0169ng tham gia v\u00e0o qu\u00e1 tr\u00ecnh n\u00e0y.<\/p>\n

2. Vai tr\u00f2 \u0111\u1ea1i th\u1ef1c b\u00e0o trong ph\u1ea3n \u1ee9ng vi\u00eam m\u1ea1n<\/h2>\n

2.1. Tr\u00ecnh di\u1ec7n kh\u00e1ng nguy\u00ean t\u1ea1i ch\u1ed7<\/h3>\n

M\u1ed9t kh\u00eda c\u1ea1nh quan tr\u1ecdng c\u1ee7a vi\u1ec7c vi\u00eam l\u00e0 s\u1ef1 tr\u00ecnh di\u1ec7n kh\u00e1ng nguy\u00ean, l\u00e0 qu\u00e1 tr\u00ecnh m\u00e0 c\u00e1c t\u1ebf b\u00e0o mi\u1ec5n d\u1ecbch tr\u00ecnh di\u1ec7n kh\u00e1ng nguy\u00ean ngo\u1ea1i lai cho c\u00e1c t\u1ebf b\u00e0o mi\u1ec5n d\u1ecbch kh\u00e1c. Qu\u00e1 tr\u00ecnh n\u00e0y gi\u00fap k\u00edch ho\u1ea1t v\u00e0 \u0111i\u1ec1u ho\u00e0 c\u00e1c ph\u1ea3n \u1ee9ng mi\u1ec5n d\u1ecbch. C\u00f3 m\u1ed9t s\u1ed1 protein b\u1ec1 m\u1eb7t tham gia v\u00e0o vi\u1ec7c tr\u00ecnh di\u1ec7n kh\u00e1ng nguy\u00ean c\u1ee7a \u0111\u1ea1i th\u1ef1c b\u00e0o, bao g\u1ed3m MHC II v\u00e0 B7 (CD80\/86), MHC I v\u00e0 B7 (CD80\/86), v\u00e0 CD40.<\/p>\n

    \n
  • C\u00e1c protein MHC II v\u00e0 B7 l\u00e0 c\u1ea7n thi\u1ebft \u0111\u1ec3 k\u00edch ho\u1ea1t l\u1ea1i t\u1ebf b\u00e0o T gi\u00fap \u0111\u1ee1 (T-helper), \u0111i\u1ec1u c\u1ea7n thi\u1ebft cho vi\u1ec7c k\u00edch ho\u1ea1t ph\u1ea3n \u1ee9ng mi\u1ec5n d\u1ecbch th\u00edch nghi (adaptive immune system).<\/li>\n
  • C\u00e1c protein MHC I v\u00e0 B7 l\u00e0 c\u1ea7n thi\u1ebft \u0111\u1ec3 k\u00edch ho\u1ea1t l\u1ea1i t\u1ebf b\u00e0o T \u0111\u1ed9c (T-cytotoxic), \u0111i\u1ec1u c\u1ea7n thi\u1ebft cho vi\u1ec7c ti\u00eau di\u1ec7t t\u1ebf b\u00e0o b\u1ea5t th\u01b0\u1eddng ho\u1eb7c b\u1ecb nhi\u1ec5m virus.<\/li>\n
  • CD40 tham gia v\u00e0o k\u00edch th\u00edch \u0111\u1ea1i th\u1ef1c b\u00e0o, d\u1eabn \u0111\u1ebfn qu\u00e1 tr\u00ecnh “nu\u1ed1t” t\u1ebf b\u00e0o, ti\u00eau di\u1ec7t t\u00e1c nh\u00e2n g\u00e2y b\u1ec7nh kh\u00f4ng ph\u1ee5 thu\u1ed9c v\u00e0o O2, v\u00e0 tr\u00ecnh di\u1ec7n kh\u00e1ng nguy\u00ean.<\/li>\n<\/ul>\n

    Qu\u00e1 tr\u00ecnh ti\u1ebft ra cytokine l\u00e0 m\u1ed9t ph\u1ea7n quan tr\u1ecdng c\u1ee7a ph\u1ea3n \u1ee9ng mi\u1ec5n d\u1ecbch v\u00e0 ph\u1ee5 thu\u1ed9c v\u00e0o lo\u1ea1i t\u1ebf b\u00e0o T gi\u00fap \u0111\u1ee1. V\u00ed d\u1ee5, c\u00e1c t\u1ebf b\u00e0o Th1 \u0111\u01b0\u1ee3c k\u00edch th\u00edch s\u1ebd ti\u1ebft ra IFN-\u03b3, sau \u0111\u00f3 k\u00edch th\u00edch c\u00e1c \u0111\u1ea1i th\u1ef1c b\u00e0o ti\u1ebft ra nhi\u1ec1u IL-12 h\u01a1n. Qu\u00e1 tr\u00ecnh n\u00e0y gi\u00fap \u0111i\u1ec1u ho\u00e0 c\u00e1c ph\u1ea3n \u1ee9ng mi\u1ec5n d\u1ecbch v\u00e0 \u0111\u1ea3m b\u1ea3o r\u1eb1ng n\u00f3 c\u00f3 hi\u1ec7u qu\u1ea3 trong vi\u1ec7c ch\u1ed1ng l\u1ea1i c\u00e1c nhi\u1ec5m tr\u00f9ng.<\/p>\n

    B\u00ean c\u1ea1nh \u0111\u00f3, b\u1ec1 m\u1eb7t \u0111\u1ea1i th\u1ef1c b\u00e0o c\u0169ng c\u00f3 CCR5 l\u00e0 m\u1ed9t th\u1ee5 th\u1ec3 chemokine, virus HIV c\u0169ng s\u1eed d\u1ee5ng CCR5 nh\u01b0 m\u1ed9t th\u1ee5 th\u1ec3 \u0111\u1ec3 x\u00e2m nh\u1eadp v\u00e0o t\u1ebf b\u00e0o.<\/p>\n

    2.2. B\u00e0i ti\u1ebft cytokine t\u1eeb \u0111\u1ea1i th\u1ef1c b\u00e0o<\/h3>\n

    Cytokine l\u00e0 m\u1ed9t nh\u00f3m protein “giao ti\u1ebfp” \u0111\u01b0\u1ee3c s\u1ea3n xu\u1ea5t b\u1edfi c\u00e1c t\u1ebf b\u00e0o mi\u1ec5n d\u1ecbch gi\u00fap c\u01a1 th\u1ec3 v\u1eadn h\u00e0nh h\u1ec7 mi\u1ec5n d\u1ecbch. Trong s\u1ed1 \u0111\u00f3, IL-1, TNF, IL-6, IL-8 v\u00e0 IL-12 \u0111\u01b0\u1ee3c s\u1ea3n xu\u1ea5t b\u1edfi \u0111\u1ea1i th\u1ef1c b\u00e0o.<\/p>\n

      \n
    • IL-1 c\u00f3 kh\u1ea3 n\u0103ng k\u00edch th\u00edch s\u1ea3n xu\u1ea5t prostaglandin, g\u00e2y ra c\u00e1c tri\u1ec7u ch\u1ee9ng s\u01b0ng, n\u00f3ng, \u0111\u1ecf v\u00e0 \u0111au. N\u00f3 c\u0169ng t\u0103ng s\u1ef1 b\u1ed9c l\u1ed9 E-selectins, ICAM v\u00e0 VCAM tr\u00ean t\u1ebf b\u00e0o n\u1ed9i m\u00f4 m\u1ea1ch m\u00e1u, \u0111\u1ed3ng th\u1eddi k\u00edch ho\u1ea1t c\u00e1c t\u1ebf b\u00e0o Th17 tham gia v\u00e0o ph\u1ea3n \u1ee9ng mi\u1ec5n d\u1ecbch th\u00edch nghi c\u1ee7a c\u01a1 th\u1ec3.<\/li>\n
    • TNF c\u0169ng c\u00f3 kh\u1ea3 n\u0103ng k\u00edch th\u00edch s\u1ea3n xu\u1ea5t prostaglandin v\u00e0 s\u1ef1 b\u1ed9c l\u1ed9 E-selectins, ICAM v\u00e0 VCAM. Ngo\u00e0i ra, n\u00f3 c\u00f2n k\u00edch ho\u1ea1t c\u00e1c t\u1ebf b\u00e0o tua (Dendritic cells) t\u1edbi khu v\u1ef1c vi\u00eam v\u00e0 t\u0103ng c\u01b0\u1eddng s\u1ef1 ph\u00e1t tri\u1ec3n c\u1ee7a c\u00e1c t\u1ebf b\u00e0o B.<\/li>\n
    • IL-6 t\u0103ng s\u1ef1 s\u1ea3n xu\u1ea5t prostaglandin \u1edf v\u00f9ng h\u1ea1 \u0111\u1ed3i g\u00e2y s\u1ed1t, t\u0103ng ti\u1ebft c\u00e1c proteins \u1edf giai \u0111o\u1ea1n c\u1ea5p. N\u00f3 c\u0169ng ho\u1ea1t \u0111\u1ed9ng nh\u01b0 m\u1ed9t t\u00edn hi\u1ec7u k\u00edch th\u00edch cho c\u00e1c t\u1ebf b\u00e0o Th17 v\u00e0 \u1ee9c ch\u1ebf s\u1ef1 ph\u00e1t tri\u1ec3n c\u1ee7a c\u00e1c t\u1ebf b\u00e0o Treg (Regulatory T cells).<\/li>\n
    • IL-8 k\u00edch th\u00edch ho\u1ea1t h\u01b0\u1edbng \u0111\u1ed9ng c\u1ee7a neutrophil, m\u1ed9t lo\u1ea1i t\u1ebf b\u00e0o mi\u1ec5n d\u1ecbch tham gia v\u00e0o qu\u00e1 tr\u00ecnh ph\u1ea3n \u1ee9ng vi\u00eam.<\/li>\n
    • IL-12 ho\u1ea1t \u0111\u1ed9ng nh\u01b0 m\u1ed9t t\u00edn hi\u1ec7u k\u00edch th\u00edch cho c\u00e1c t\u1ebf b\u00e0o NK (natural killer cells) v\u00e0 c\u00e1c t\u1ebf b\u00e0o Th1 tham gia v\u00e0o ph\u1ea3n \u1ee9ng mi\u1ec5n d\u1ecbch ch\u1ed1ng l\u1ea1i c\u00e1c vi khu\u1ea9n v\u00e0 virus.<\/li>\n<\/ul>\n

      2.3 H\u00ecnh th\u00e0nh u h\u1ea1t<\/h3>\n

      U h\u1ea1t (granuloma) l\u00e0 m\u1ed9t d\u1ea1ng vi\u00eam m\u1ea1n t\u00ednh c\u00f3 th\u1ec3 \u0111\u01b0\u1ee3c chia th\u00e0nh hai lo\u1ea1i: vi\u00eam kh\u00f4ng h\u1ea1t (nongranulomatous) v\u00e0 vi\u00eam h\u1ea1t (granulomatous). Trong \u0111\u00f3 vi\u00eam h\u1ea1t \u0111\u01b0\u1ee3c chia l\u00e0m hai lo\u1ea1i:<\/p>\n

        \n
      • Noncaseating Granulomas: \u0111\u01b0\u1ee3c h\u00ecnh th\u00e0nh nh\u1edd Th1 ti\u1ebft IFN-\u03b3 bi\u1ebfn c\u00e1c \u0111\u1ea1i th\u1ef1c b\u00e0o th\u00e0nh c\u00e1c epithelioid cells<\/em> (thon d\u00e0i, h\u00ecnh kh\u1ed1i gi\u1ed1ng v\u1edbi c\u00e1c t\u1ebf b\u00e0o n\u1ed9i m\u00f4 – epithelium cells). Nh\u1eefng t\u1ebf b\u00e0o n\u00e0y h\u1ee3p l\u1ea1i v\u1edbi nhau t\u1ea1o th\u00e0nh t\u1ebf b\u00e0o kh\u1ed5ng l\u1ed3 \u0111a nh\u00e2n (multinucleated giant cells). C\u1ea3 hai lo\u1ea1i n\u00e0y bao quanh v\u1ecb tr\u00ed vi\u00eam t\u1ea1o th\u00e0nh u h\u1ea1t (granuloma). Bi\u1ec3u hi\u1ec7n tr\u00ean k\u00ednh hi\u1ec3u vi l\u00e0 m\u1ed9t c\u1ee5m t\u1ebf b\u00e0o c\u00f3 nh\u00e2n h\u00ecnh oval\u00a0 v\u1edbi b\u00e0o t\u01b0\u01a1ng m\u00e0u h\u1ed3ng, bao xung quanh b\u1edfi c\u00e1c t\u1ebf b\u00e0o Th1.<\/li>\n
      • Caseating Granulomas: c\u00f3 c\u00f9ng qu\u00e1 tr\u00ecnh h\u00ecnh th\u00e0nh nh\u01b0 Noncaseating Granulomas, nh\u01b0ng c\u00f2n c\u00f3 s\u1ef1 ph\u00e2n h\u1ee7y trung t\u00e2m (c\u00e1c t\u1ebf b\u00e0o kh\u00f4ng c\u00f3 h\u1ea1t nh\u00e2n), \u0111i\u1ec1u n\u00e0y c\u00f3 th\u1ec3 ch\u1ec9 \u0111i\u1ec3m lao ph\u1ed5i (tuberculosis) ho\u1eb7c c\u00e1c b\u1ec7nh n\u1ea5m khu\u1ea9n h\u1ec7 th\u1ed1ng nh\u01b0 Histoplasmosis, Blastomycosis, Coccidiomycosis, ho\u1eb7c Paracoccidioidomycosis.<\/li>\n<\/ul>\n

        Qu\u00e1 tr\u00ecnh h\u00ecnh th\u00e0nh u h\u1ea1t \u0111\u01b0\u1ee3c gi\u1eef v\u1eefng nh\u1edd c\u00e1c t\u1ebf b\u00e0o epithelioid ti\u1ebft ra TNF gi\u00fap c\u00e1c u h\u1ea1t kh\u00f4ng b\u1ecb ph\u00e1 hu\u1ef7.<\/p>\n

        \"Mo-benh-hoc-cua-noncaseating-granuloma\"
        M\u00f4 b\u1ec7nh h\u1ecdc c\u1ee7a noncaseating granuloma<\/figcaption><\/figure>\n
        \"Mo-benh-hoc-Caseating-Granuloma
        M\u00f4 b\u1ec7nh h\u1ecdc Caseating Granuloma<\/figcaption><\/figure>\n

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        <\/h2>\n

        3. K\u1ebft Lu\u1eadn:<\/h2>\n

        \u0110\u1ea1i th\u1ef1c b\u00e0o \u0111\u00f3ng vai tr\u00f2 quan tr\u1ecdng trong qu\u00e1 tr\u00ecnh vi\u00eam m\u1ea1n bao g\u1ed3m tr\u00ecnh di\u1ec7n kh\u00e1ng nguy\u00ean t\u1ea1i ch\u1ed7, b\u1eb1ng c\u00e1ch b\u00e0i ti\u1ebft cytokine v\u00e0 h\u00ecnh th\u00e0nh u t\u1ebf b\u00e0o. C\u00e1c t\u1ebf b\u00e0o mi\u1ec5n d\u1ecbch n\u00e0y c\u0169ng tham gia v\u00e0o qu\u00e1 tr\u00ecnh ph\u00e1t tri\u1ec3n c\u1ee7a vi\u00eam c\u1ea5p t\u00ednh b\u1eb1ng c\u00e1ch th\u1ef1c hi\u1ec7n qu\u00e1 tr\u00ecnh th\u1ef1c b\u00e0o, b\u00e0i ti\u1ebft cytokine v\u00e0 c\u00f3 kh\u1ea3 n\u0103ng h\u00ecnh th\u00e0nh \u00e1p xe. Hi\u1ec3u r\u00f5 h\u01a1n v\u1ec1 vai tr\u00f2 c\u1ee7a \u0111\u1ea1i th\u1ef1c b\u00e0o trong ph\u1ea3n \u1ee9ng vi\u00eam c\u00f3 th\u1ec3 gi\u00fap ch\u00fang ta c\u00f3 th\u00e1i \u0111\u1ed9 \u0111\u00fang \u0111\u1eafn trong vi\u1ec7c \u0111i\u1ec1u tr\u1ecb c\u00e1c b\u1ec7nh vi\u00eam c\u1ea5p v\u00e0 m\u00e3n t\u00ednh.<\/p>\n

        T\u00e0i li\u1ec7u tham kh\u1ea3o<\/strong>
        \nAbul K Abbas, Andrew H. Lichtman, and Shiv Oillai. 2021. Cellular and Molecular Immunology. 10th ed.
        \nPhyseo Immunology AFT 2021<\/p>\n

         <\/p>\n","protected":false},"excerpt":{"rendered":"

        \u0110\u1ea1i th\u1ef1c b\u00e0o (Macrophages) l\u00e0 lo\u1ea1i t\u1ebf b\u00e0o mi\u1ec5n d\u1ecbch quan tr\u1ecdng trong qu\u00e1 tr\u00ecnh ph\u1ea3n \u1ee9ng vi\u00eam c\u1ea5p t\u00ednh. Trong tr\u01b0\u1eddng h\u1ee3p n\u00e0y, ch\u00fang ph\u1ea3n \u1ee9ng v\u1edbi c\u00e1c t\u00e1c nh\u00e2n g\u00e2y vi\u00eam b\u1eb1ng c\u00e1ch ti\u1ebft ra c\u00e1c ch\u1ea5t g\u00e2y vi\u00eam nh\u01b0 cytokines v\u00e0 chemokines, \u0111\u1ed3ng th\u1eddi k\u00edch ho\u1ea1t c\u00e1c t\u1ebf b\u00e0o kh\u00e1c \u0111\u1ec3 di […]<\/p>\n","protected":false},"author":55,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[73,33],"tags":[],"yoast_head":"\n\u0110\u1ea1i th\u1ef1c b\u00e0o: Vai tr\u00f2 trong ph\u1ea3n \u1ee9ng vi\u00eam m\u1ea1n - Vinmec<\/title>\n<meta name=\"description\" content=\"Vai tr\u00f2 \u0111\u1ea1i th\u1ef1c b\u00e0o trong qu\u00e1 tr\u00ecnh vi\u00eam m\u1ea1n: tr\u00ecnh di\u1ec7n kh\u00e1ng nguy\u00ean t\u1ea1i ch\u1ed7, b\u1eb1ng c\u00e1ch b\u00e0i ti\u1ebft cytokine v\u00e0 h\u00ecnh th\u00e0nh u t\u1ebf b\u00e0o.\" \/>\n<meta name=\"robots\" content=\"noindex, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"\u0110\u1ea1i th\u1ef1c b\u00e0o: Vai tr\u00f2 trong ph\u1ea3n \u1ee9ng vi\u00eam m\u1ea1n - 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