{"id":30800,"date":"2023-05-03T14:54:06","date_gmt":"2023-05-03T07:54:06","guid":{"rendered":"http:\/\/noithathoaphat.in\/ctv\/?p=30800"},"modified":"2023-05-03T14:54:17","modified_gmt":"2023-05-03T07:54:17","slug":"chan-doan-tang-lipid-mau-gia-dinh-esc-2019","status":"publish","type":"post","link":"http:\/\/noithathoaphat.in\/ctv\/index.php\/2023\/05\/03\/chan-doan-tang-lipid-mau-gia-dinh-esc-2019\/","title":{"rendered":"Ch\u1ea9n \u0111o\u00e1n t\u0103ng lipid m\u00e1u gia \u0111\u00ecnh \u2013 ESC 2019"},"content":{"rendered":"

B\u1ec7nh t\u0103ng lipid m\u00e1u gia \u0111\u00ecnh<\/a> ( Familial hypercholesterolemia, vi\u1ebft t\u1eaft: FH) l\u00e0 r\u1ed1i lo\u1ea1n chuy\u1ec3n h\u00f3a lipid m\u00e1u di truy\u1ec1n. Ng\u01b0\u1eddi ch\u1ee9ng t\u0103ng cholesterol m\u00e1u t\u00ednh ch\u1ea5t gia \u0111\u00ecnh \u0111\u1ed3ng h\u1ee3p t\u1eed c\u1ea7n ch\u1ebf \u0111\u1ed9 \u0103n u\u1ed1ng, thu\u1ed1c, v\u00e0 th\u01b0\u1eddng d\u00f9ng l\u1ecdc LDL huy\u1ebft t\u01b0\u01a1ng \u0111\u1ec3 ng\u0103n ng\u1eeba t\u1eed vong s\u1edbm; \u0111i\u1ec1u tr\u1ecb b\u1eaft \u0111\u1ea7u khi ch\u1ea9n \u0111o\u00e1n \u0111\u01b0\u1ee3c th\u1ef1c hi\u1ec7n.<\/strong><\/p>\n

1. R\u1ed1i lo\u1ea1n lipid m\u00e1u gia \u0111\u00ecnh<\/h2>\n

N\u1ed3ng \u0111\u1ed9 lipid huy\u1ebft t\u01b0\u01a1ng, \u1edf m\u1ed9t m\u1ee9c \u0111\u1ed9 r\u1ea5t l\u1edbn, \u0111\u01b0\u1ee3c quy\u1ebft \u0111\u1ecbnh b\u1edfi c\u00e1c y\u1ebfu t\u1ed1 di truy\u1ec1n. \u1ede nh\u1eefng d\u1ea1ng c\u1ef1c \u0111\u1ed9 h\u01a1n, n\u00f3 bi\u1ec3u hi\u1ec7n l\u00e0 ch\u1ee9ng r\u1ed1i lo\u1ea1n lipid m\u00e1u gia \u0111\u00ecnh. M\u1ed9t s\u1ed1 r\u1ed1i lo\u1ea1n lipid \u0111\u01a1n gen \u0111\u00e3 \u0111\u01b0\u1ee3c x\u00e1c \u0111\u1ecbnh; trong s\u1ed1 n\u00e0y, FH l\u00e0 th\u01b0\u1eddng g\u1eb7p nh\u1ea5t v\u00e0 li\u00ean quan ch\u1eb7t ch\u1ebd \u0111\u1ebfn CVD. N\u00f3i chung, \u1edf m\u1ed9t b\u1ec7nh nh\u00e2n r\u1ed1i lo\u1ea1n lipid m\u00e1u, ki\u1ec3u di truy\u1ec1n th\u01b0\u1eddng kh\u00f4ng g\u1ee3i \u00fd r\u1eb1ng c\u00f3 m\u1ed9t r\u1ed1i lo\u1ea1n gen \u0111\u01a1n l\u1edbn g\u00e2y ra s\u1ef1 b\u1ea5t th\u01b0\u1eddng n\u00e0y; thay v\u00e0o \u0111\u00f3, n\u00f3 b\u1eaft ngu\u1ed3n t\u1eeb s\u1ef1 di truy\u1ec1n c\u1ee7a h\u01a1n m\u1ed9t bi\u1ebfn th\u1ec3 gen \u1ea3nh h\u01b0\u1edfng \u0111\u1ebfn qu\u00e1 tr\u00ecnh chuy\u1ec3n h\u00f3a lipoprotein m\u00e0 b\u1ea3n th\u00e2n n\u00f3 c\u00f3 th\u1ec3 c\u00f3 \u1ea3nh h\u01b0\u1edfng t\u01b0\u01a1ng \u0111\u1ed1i \u00edt, nh\u01b0ng k\u1ebft h\u1ee3p v\u1edbi m\u1ed9t ho\u1eb7c nhi\u1ec1u bi\u1ebfn th\u1ec3 kh\u00e1c th\u00ec l\u1ea1i c\u00f3 \u1ea3nh h\u01b0\u1edfng l\u1edbn h\u01a1n \u0111\u1ebfn TC, TG ho\u1eb7c HDL-C. Ki\u1ec3u di truy\u1ec1n l\u00e0 \u0111a gen [357]. Ng\u01b0\u1eddi ta th\u01b0\u1eddng th\u1ea5y r\u1eb1ng m\u1ee9c LDL-C cao, TG cao ho\u1eb7c HDL-C th\u1ea5p \u1ea3nh h\u01b0\u1edfng \u0111\u1ebfn m\u1ed9t s\u1ed1 th\u00e0nh vi\u00ean c\u1ee7a gia \u0111\u00ecnh.<\/p>\n

\"tang-lipid-mau-gia-dinh\"<\/p>\n

2.\u00a0 T\u0103ng lipid m\u00e1u k\u1ebft h\u1ee3p gia \u0111\u00ecnh<\/h2>\n

T\u0103ng lipid m\u00e1u k\u1ebft h\u1ee3p gia \u0111\u00ecnh (FCH) l\u00e0 m\u1ed9t r\u1ed1i lo\u1ea1n lipid m\u00e1u h\u1ed7n h\u1ee3p r\u1ea5t ph\u1ed5 bi\u1ebfn (1 : 100-200) \u0111\u01b0\u1ee3c \u0111\u1eb7c tr\u01b0ng b\u1edfi n\u1ed3ng \u0111\u1ed9 LDL-C, TG, ho\u1eb7c c\u1ea3 hai \u0111\u1ec1u cao, v\u00e0 l\u00e0 m\u1ed9t nguy\u00ean nh\u00e2n quan tr\u1ecdng c\u1ee7a CAD s\u1edbm. FCH l\u00e0 m\u1ed9t b\u1ec7nh l\u00fd ph\u1ee9c t\u1ea1p v\u00e0 ki\u1ec3u h\u00ecnh \u0111\u01b0\u1ee3c quy\u1ebft \u0111\u1ecbnh b\u1edfi s\u1ef1 t\u01b0\u01a1ng t\u00e1c c\u1ee7a nhi\u1ec1u gen nh\u1ea1y c\u1ea3m v\u00e0 m\u00f4i tr\u01b0\u1eddng. N\u00f3 c\u00f3 s\u1ef1 tr\u00f9ng l\u1eb7p \u0111\u00e1ng k\u1ec3 v\u1edbi c\u00e1c ki\u1ec3u h\u00ecnh r\u1ed1i lo\u1ea1n lipid m\u00e1u c\u1ee7a T2DM v\u00e0 MetS. Ngay c\u1ea3 trong m\u1ed9t gia \u0111\u00ecnh, ki\u1ec3u h\u00ecnh c\u0169ng kh\u00e1c nhau r\u1ea5t nhi\u1ec1u gi\u1eefa nh\u1eefng c\u00e1 th\u1ec3 v\u00e0 trong c\u00f9ng c\u00e1 th\u1ec3 d\u1ef1a tr\u00ean c\u00e1c gi\u00e1 tr\u1ecb lipid (TG, LDL-C, HDL-C v\u00e0 ApoB). FCH kh\u00f4ng c\u00f3 th\u00e0nh ph\u1ea7n \u0111\u01a1n gen g\u00e2y b\u1ec7nh v\u00e0 kh\u00f4ng li\u00ean k\u1ebft v\u1edbi m\u1ed9t nguy\u00ean nh\u00e2n di truy\u1ec1n \u0111\u01a1n \u0111\u1ed9c, nh\u01b0ng ki\u1ec3u h\u00ecnh l\u00e0 LDL-C cao v\u00e0\/ho\u1eb7c TG cao [358,359]. Do \u0111\u00f3, ch\u1ea9n \u0111o\u00e1n th\u01b0\u1eddng b\u1ecb b\u1ecf qua trong th\u1ef1c h\u00e0nh l\u00e2m s\u00e0ng; s\u1ef1 k\u1ebft h\u1ee3p c\u1ee7a ApoB >120 mg\/dL v\u00e0 TG >1.5 mmol\/L (>133 mg\/dL) v\u1edbi ti\u1ec1n s\u1eed gia \u0111\u00ecnh CVD s\u1edbm c\u00f3 th\u1ec3 \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng \u0111\u1ec3 x\u00e1c \u0111\u1ecbnh nh\u1eefng ng\u01b0\u1eddi c\u00f3 kh\u1ea3 n\u0103ng m\u1eafc FCH [360].
\nB\u1ea3ng. C\u00e1c r\u1ed1i lo\u1ea1n di truy\u1ec1n chuy\u1ec3n h\u00f3a lipoprotein<\/p>\n\n\n\n\n\n\n\n\n\n\n
R\u1ed1i lo\u1ea1n\u00a0<\/strong><\/td>\nT\u1ea7n su\u1ea5t\u00a0<\/strong><\/td>\nGen\u00a0<\/strong><\/td>\n\u1ea2nh h\u01b0\u01a1ng \u0111\u1ebfn<\/strong>\u00a0 lipoprotein<\/strong><\/td>\n<\/tr>\n
HeFH<\/td>\n1 trong 200- 250<\/td>\nLDLR<\/p>\n

APO B<\/p>\n

PCSK9<\/td>\n

\u2191 LDL-C<\/td>\n<\/tr>\n
HoFH<\/td>\n1 trong<\/p>\n

160,000-<\/p>\n

320,000<\/td>\n

LDLR<\/p>\n

APO B<\/p>\n

PCSK9<\/td>\n

\u2191\u2191 LDL-C<\/td>\n<\/tr>\n
FCH<\/td>\n1 trong 100- 200<\/td>\nUSF1 + gen \u00a0\u0111i\u1ec1u ch\u1ec9nh<\/td>\n\u2191 LDL-C, \u2191 VLDL-C, \u00a0\u2191 ApoB<\/td>\n<\/tr>\n
R\u1ed1i lo\u1ea1n betalipoprotein m\u00e1u gia \u0111\u00ecnh<\/td>\n1 trong<\/p>\n

5000<\/td>\n

APO E<\/td>\n\u2191\u2191 IDL v\u00e0 chylomicron \u00a0c\u00f2n s\u00f3t l\u1ea1i (bVLDL)<\/td>\n<\/tr>\n
Familial lipoprotein lipase \u00a0deficiency (familial<\/p>\n

chylomicron syndrome)<\/td>\n

2 trong 106\u00a0<\/sup><\/td>\nLPL<\/p>\n

APO C2<\/p>\n

ApoAV,<\/p>\n

GPIHBP1<\/p>\n

LMF1<\/td>\n

\u2191\u2191 chylomicron v\u00e0 \u00a0VLDL-C<\/td>\n<\/tr>\n
Tangier disease<\/p>\n

(analphalipoproteinaemia)<\/td>\n

1 trong 106\u00a0<\/sup><\/td>\nABCA1<\/td>\n\u2193\u2193 HDL-C<\/td>\n<\/tr>\n
Thi\u1ebfu LCAT gia \u0111\u00ecnh<\/td>\n1 trong 106\u00a0<\/sup><\/td>\nLCAT<\/td>\n\u2193 HDL-C<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

* Apo = apolipoprotein; FCH = t\u0103ng lipid m\u00e1u k\u1ebft h\u1ee3p gia \u0111\u00ecnh; HDL-C = cholesterol lipoprotein m\u1eadt \u0111\u1ed9 cao; HeFH = t\u0103ng cholesterol m\u00e1u gia \u0111\u00ecnh d\u1ecb h\u1ee3p t\u1eed; HoFH = t\u0103ng cholesterol m\u00e1u gia \u0111\u00ecnh \u0111\u1ed3ng h\u1ee3p t\u1eed; IDL = lipoprotein m\u1eadt \u0111\u1ed9 trung gian; LCAT = lecithin cholesterol acyltransferase; LDL-C = cholesterol lipoprotein m\u1eadt \u0111\u1ed9 th\u1ea5p; VLDL = cholesterol lipoprotein m\u1eadt \u0111\u1ed9 r\u1ea5t th\u1ea5p.
\nKh\u00e1i ni\u1ec7m v\u1ec1 r\u1ed1i lo\u1ea1n lipid m\u00e1u h\u1ed7n h\u1ee3p c\u0169ng c\u00f3 gi\u00e1 tr\u1ecb l\u00e2m s\u00e0ng trong vi\u1ec7c \u0111\u00e1nh gi\u00e1 nguy c\u01a1 CV. N\u00f3 nh\u1ea5n m\u1ea1nh t\u1ea7m quan tr\u1ecdng c\u1ee7a vi\u1ec7c xem x\u00e9t l\u1ecbch s\u1eed gia \u0111\u00ecnh trong vi\u1ec7c quy\u1ebft \u0111\u1ecbnh m\u1ee9c \u0111\u1ed9 nghi\u00eam ng\u1eb7t c\u1ee7a vi\u1ec7c \u0111i\u1ec1u tr\u1ecb r\u1ed1i lo\u1ea1n lipid m\u00e1u v\u00e0 m\u1ee9c LDL-C cao b\u00e1o hi\u1ec7u nguy c\u01a1 cao h\u01a1n khi HTG c\u0169ng cao. \u0110i\u1ec1u tr\u1ecb statin \u1edf ng\u01b0\u1eddi b\u1ecb HTG l\u00e0m gi\u1ea3m nguy c\u01a1 CV g\u1ea7n t\u01b0\u01a1ng t\u1ef1 nh\u01b0 \u1edf nh\u1eefng ng\u01b0\u1eddi kh\u00f4ng HTG. B\u1edfi v\u00ec nguy c\u01a1 tuy\u1ec7t \u0111\u1ed1i th\u01b0\u1eddng l\u1edbn h\u01a1n \u1edf nh\u1eefng ng\u01b0\u1eddi n\u00e0y, do \u0111\u00f3 h\u1ecd c\u00f3 th\u1ec3 h\u01b0\u1edfng l\u1ee3i r\u1ea5t nhi\u1ec1u t\u1eeb li\u1ec7u ph\u00e1p h\u1ea1 LDL.
\nB\u1ea3ng. Ti\u00eau chu\u1ea9n Dutch Lipid Clinic Network \u0111\u1ec3 ch\u1ea9n \u0111o\u00e1n t\u0103ng cholesterol m\u00e1u gia \u0111\u00ecnh<\/p>\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n
Ti\u00eau ch\u00ed \u0110i\u1ec3m<\/strong><\/td>\n<\/tr>\n
1) Ti\u1ec1n s\u1eed gia \u0111\u00ecnh<\/strong><\/td>\n<\/tr>\n
H\u1ecd h\u00e0ng m\u1ed9t \u0111\u1eddi m\u1eafc b\u1ec7nh m\u1ea1ch m\u00e1u ho\u1eb7c m\u1ea1ch v\u00e0nh s\u1edbm (nam <55 tu\u1ed5i; \u00a0n\u1eef <60 tu\u1ed5i), ho\u1eb7c h\u1ecd h\u00e0ng m\u1ed9t \u0111\u1eddi c\u00f3 LDL-C tr\u00ean b\u00e1ch ph\u00e2n v\u1ecb th\u1ee9 95<\/td>\n1<\/td>\n<\/tr>\n
H\u1ecd h\u00e0ng m\u1ed9t \u0111\u1eddi b\u1ecb u v\u00e0ng g\u00e2n v\u00e0\/ho\u1eb7c \u0111\u1ee5c r\u00eca gi\u00e1c m\u1ea1c, ho\u1eb7c tr\u1ebb em d\u01b0\u1edbi \u00a018 tu\u1ed5i c\u00f3 LDL-C tr\u00ean b\u00e1ch ph\u00e2n v\u1ecb th\u1ee9 95<\/td>\n2<\/td>\n<\/tr>\n
2) B\u1ec7nh s\u1eed l\u00e2m s\u00e0ng<\/strong><\/td>\n<\/tr>\n
B\u1ec7nh nh\u00e2n b\u1ecb CAD s\u1edbm (nam <55 tu\u1ed5i; n\u1eef <60 tu\u1ed5i)<\/td>\n2<\/td>\n<\/tr>\n
B\u1ec7nh nh\u00e2n b\u1ecb b\u1ec7nh m\u1ea1ch m\u00e1u n\u00e3o ho\u1eb7c ngo\u1ea1i bi\u00ean s\u1edbm (nam <55 tu\u1ed5i; n\u1eef <60 tu\u1ed5i)<\/td>\n1<\/td>\n<\/tr>\n
3) Kh\u00e1m th\u1ef1c th\u1ec3<\/strong>a<\/sup><\/strong><\/td>\n<\/tr>\n
U v\u00e0ng g\u00e2n<\/td>\n6<\/td>\n<\/tr>\n
\u0110\u1ee5c r\u00eca gi\u00e1c m\u1ea1c tr\u01b0\u1edbc 45 tu\u1ed5i<\/td>\n4<\/td>\n<\/tr>\n
4) N\u1ed3ng \u0111\u1ed9 LDL-C (ch\u01b0a \u0111i\u1ec1u tr\u1ecb)<\/strong><\/td>\n<\/tr>\n
LDL-C \u22658.5 mmol\/L (\u2265325 mg\/dL)<\/td>\n8<\/td>\n<\/tr>\n
LDL-C 6.5-8.4 mmol\/L (251-325 mg\/dL)<\/td>\n5<\/td>\n<\/tr>\n
LDL-C 5.0-6.4 mmol\/L (191-250 mg\/dL)<\/td>\n3<\/td>\n<\/tr>\n
LDL-C 4.0-4.9 mmol\/L (155-190 mg\/dL)<\/td>\n1<\/td>\n<\/tr>\n
5) Ph\u00e2n t\u00edch DNA<\/strong><\/td>\n<\/tr>\n
\u0110\u1ed9t bi\u1ebfn ch\u1ee9c n\u0103ng trong c\u00e1c gen LDLR, apoB ho\u1eb7c PCSK9<\/td>\n8<\/td>\n<\/tr>\n
Ch\u1ec9 ch\u1ecdn m\u1ed9t \u0111i\u1ec3m cho m\u1ed7i nh\u00f3m, m\u1ee9c \u00e1p d\u1ee5ng cao nh\u1ea5t; ch\u1ea9n \u0111o\u00e1n d\u1ef1a tr\u00ean \u00a0t\u1ed5ng s\u1ed1 \u0111i\u1ec3m thu \u0111\u01b0\u1ee3c<\/p>\n

Ch\u1ea9n \u0111o\u00e1n ‘x\u00e1c \u0111\u1ecbnh’ FH y\u00eau c\u1ea7u >8 \u0111i\u1ec3m<\/p>\n

Ch\u1ea9n \u0111o\u00e1n ‘c\u00f3 kh\u1ea3 n\u0103ng’ FH y\u00eau c\u1ea7u 6-8 \u0111i\u1ec3m<\/p>\n

Ch\u1ea9n \u0111o\u00e1n ‘c\u00f3 th\u1ec3’ FH y\u00eau c\u1ea7u 3-5 \u0111i\u1ec3m<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

* CAD = b\u1ec7nh \u0111\u1ed9ng m\u1ea1ch v\u00e0nh; FH = t\u0103ng cholesterol m\u00e1u gia \u0111\u00ecnh; LDL-C = cholesterol lipoprotein m\u1eadt \u0111\u1ed9 th\u1ea5p; PCSK9 = proprotein convertase subtilisin\/kexin lo\u1ea1i 9.<\/p>\n

3. Ph\u00e2n lo\u1ea1i<\/h2>\n

T\u0103ng cholesterol m\u00e1u gia \u0111\u00ecnh d\u1ecb h\u1ee3p t\u1eed\u00a0 (HeFH)<\/i><\/strong><\/p>\n

FH l\u00e0 m\u1ed9t r\u1ed1i lo\u1ea1n lipid m\u00e1u \u0111\u01a1n gen \u0111\u1ed3ng tr\u1ed9i th\u01b0\u1eddng g\u1eb7p g\u00e2y ra CVD s\u1edbm do t\u0103ng\u00a0 LDL-C huy\u1ebft t\u01b0\u01a1ng su\u1ed1t \u0111\u1eddi. N\u1ebfu kh\u00f4ng \u0111\u01b0\u1ee3c \u0111i\u1ec1u tr\u1ecb, nam gi\u1edbi v\u00e0 ph\u1ee5 n\u1eef m\u1eafc\u00a0 HeFH th\u01b0\u1eddng ph\u00e1t tri\u1ec3n CAD s\u1edbm l\u1ea7n l\u01b0\u1ee3t tr\u01b0\u1edbc tu\u1ed5i 55 v\u00e0 60.<\/span><\/p>\n

T\u0103ng cholesterol m\u00e1u gia \u0111\u00ecnh \u0111\u1ed3ng h\u1ee3p t\u1eed (HoFH)<\/strong><\/i><\/strong><\/p>\n

HoFH l\u00e0 m\u1ed9t b\u1ec7nh hi\u1ebfm g\u1eb7p v\u00e0 \u0111e d\u1ecda t\u00ednh m\u1ea1ng. H\u00ecnh \u1ea3nh l\u00e2m s\u00e0ng \u0111\u01b0\u1ee3c \u0111\u1eb7c tr\u01b0ng\u00a0 b\u1edfi c\u00e1c u v\u00e0ng nhi\u1ec1u n\u01a1i, CVD s\u1edbm v\u00e0 ti\u1ebfn tri\u1ec3n r\u00f5 r\u1ec7t, TC >13 mmol\/L (>500\u00a0 mg\/dL). H\u1ea7u h\u1ebft b\u1ec7nh nh\u00e2n ph\u00e1t tri\u1ec3n CAD v\u00e0 h\u1eb9p \u0111\u1ed9ng m\u1ea1ch ch\u1ee7 tr\u01b0\u1edbc 20 tu\u1ed5i v\u00e0\u00a0 ch\u1ebft tr\u01b0\u1edbc 30 tu\u1ed5i.<\/span><\/p>\n

T\u00c0I LI\u1ec6U THAM KH\u1ea2O:<\/strong> H\u01b0\u1edbng d\u1eabn ESC\/EAS 2019 v\u1ec1 qu\u1ea3n l\u00fd r\u1ed1i lo\u1ea1n lipid m\u00e1u: \u0111i\u1ec1u ch\u1ec9nh lipid \u0111\u1ec3 gi\u1ea3m nguy c\u01a1 tim m\u1ea1ch<\/p>\n","protected":false},"excerpt":{"rendered":"

B\u1ec7nh t\u0103ng lipid m\u00e1u gia \u0111\u00ecnh ( Familial hypercholesterolemia, vi\u1ebft t\u1eaft: FH) l\u00e0 r\u1ed1i lo\u1ea1n chuy\u1ec3n h\u00f3a lipid m\u00e1u di truy\u1ec1n. Ng\u01b0\u1eddi ch\u1ee9ng t\u0103ng cholesterol m\u00e1u t\u00ednh ch\u1ea5t gia \u0111\u00ecnh \u0111\u1ed3ng h\u1ee3p t\u1eed c\u1ea7n ch\u1ebf \u0111\u1ed9 \u0103n u\u1ed1ng, thu\u1ed1c, v\u00e0 th\u01b0\u1eddng d\u00f9ng l\u1ecdc LDL huy\u1ebft t\u01b0\u01a1ng \u0111\u1ec3 ng\u0103n ng\u1eeba t\u1eed vong s\u1edbm; \u0111i\u1ec1u tr\u1ecb b\u1eaft […]<\/p>\n","protected":false},"author":16,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[7,33],"tags":[],"yoast_head":"\nCh\u1ea9n \u0111o\u00e1n t\u0103ng lipid m\u00e1u gia \u0111\u00ecnh \u2013 ESC 2019 - Vinmec<\/title>\n<meta name=\"description\" content=\"B\u1ec7nh t\u0103ng lipid m\u00e1u gia \u0111\u00ecnh ( Familial hypercholesterolemia, vi\u1ebft t\u1eaft: FH) l\u00e0 r\u1ed1i lo\u1ea1n chuy\u1ec3n h\u00f3a lipid m\u00e1u di truy\u1ec1n.\" \/>\n<meta name=\"robots\" content=\"noindex, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Ch\u1ea9n \u0111o\u00e1n t\u0103ng lipid m\u00e1u gia \u0111\u00ecnh \u2013 ESC 2019 - 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