{"id":30680,"date":"2023-05-03T18:13:10","date_gmt":"2023-05-03T11:13:10","guid":{"rendered":"http:\/\/noithathoaphat.in\/ctv\/?p=30680"},"modified":"2023-05-03T18:13:10","modified_gmt":"2023-05-03T11:13:10","slug":"tuong-tac-thuoc-giua-ondansetron-va-dofetilide","status":"publish","type":"post","link":"http:\/\/noithathoaphat.in\/ctv\/index.php\/2023\/05\/03\/tuong-tac-thuoc-giua-ondansetron-va-dofetilide\/","title":{"rendered":"T\u01b0\u01a1ng t\u00e1c thu\u1ed1c gi\u1eefa Ondansetron v\u00e0 Dofetilide"},"content":{"rendered":"<p><strong>T\u01b0\u01a1ng t\u00e1c thu\u1ed1c l\u00e0 hi\u1ec7n t\u01b0\u1ee3ng khi hai ho\u1eb7c nhi\u1ec1u lo\u1ea1i thu\u1ed1c \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng c\u00f9ng nhau v\u00e0 t\u00e1c \u0111\u1ed9ng l\u00ean nhau trong c\u01a1 th\u1ec3. T\u01b0\u01a1ng t\u00e1c n\u00e0y c\u00f3 th\u1ec3 \u1ea3nh h\u01b0\u1edfng \u0111\u1ebfn hi\u1ec7u qu\u1ea3 \u0111i\u1ec1u tr\u1ecb ho\u1eb7c g\u00e2y ra c\u00e1c t\u00e1c d\u1ee5ng ph\u1ee5 nghi\u00eam tr\u1ecdng. M\u1ed9t trong nh\u1eefng t\u01b0\u01a1ng t\u00e1c thu\u1ed1c ti\u1ec1m n\u0103ng l\u00e0 t\u01b0\u01a1ng t\u00e1c gi\u1eefa Ondansetron v\u00e0 Dofetilide. Ondansetron \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng \u0111\u1ec3 \u0111i\u1ec1u tr\u1ecb bu\u1ed3n n\u00f4n v\u00e0 n\u00f4n, trong khi Dofetilide \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng \u0111\u1ec3 \u0111i\u1ec1u tr\u1ecb nh\u1ecbp tim b\u1ea5t th\u01b0\u1eddng. Tuy nhi\u00ean, khi \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng c\u00f9ng nhau, ch\u00fang c\u00f3 th\u1ec3 l\u00e0m t\u0103ng nguy c\u01a1 nh\u1ecbp tim kh\u00f4ng \u0111\u1ec1u v\u00e0 c\u00f3 th\u1ec3 g\u00e2y \u0111e d\u1ecda t\u00ednh m\u1ea1ng.\u00a0 C\u00e1c chuy\u00ean gia y t\u1ebf c\u1ea7n hi\u1ec3u r\u00f5 t\u00ednh nghi\u00eam tr\u1ecdng c\u1ee7a t\u01b0\u01a1ng t\u00e1c n\u00e0y v\u00e0 c\u1ea3 b\u1ec7nh nh\u00e2n n\u00ean th\u1ea3o lu\u1eadn v\u1edbi b\u00e1c s\u0129 c\u1ee7a m\u00ecnh v\u1ec1 t\u00e1c d\u1ee5ng ph\u1ee5 c\u00f3 th\u1ec3 x\u1ea3y ra v\u00e0 t\u00ecm ki\u1ebfm s\u1ef1 ch\u0103m s\u00f3c y t\u1ebf ngay l\u1eadp t\u1ee9c n\u1ebfu c\u00f3 b\u1ea5t k\u1ef3 tri\u1ec7u ch\u1ee9ng n\u00e0o x\u1ea3y ra.<\/strong><\/p>\n<h2><strong>1.T\u00ecm hi\u1ec3u v\u1ec1 Ondansetron<\/strong><\/h2>\n<h3><span style=\"font-weight: 400;\">1.1 Gi\u1edbi thi\u1ec7u chung\u00a0<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">N\u0103m 1991, C\u01a1 quan Qu\u1ea3n l\u00fd Th\u1ef1c ph\u1ea9m v\u00e0 D\u01b0\u1ee3c ph\u1ea9m Hoa K\u1ef3 (FDA) \u0111\u00e3 ph\u00ea duy\u1ec7t <a href=\"https:\/\/www.vinmec.com\/vi\/thong-tin-duoc\/su-dung-thuoc-toan\/cong-dung-thuoc-zofran\/\">Zofran<\/a> (Ondansetron), \u0111\u00e2y l\u00e0 lo\u1ea1i thu\u1ed1c \u0111\u1ea7u ti\u00ean trong nh\u00f3m thu\u1ed1c m\u1edbi c\u00f3 t\u00ean l\u00e0 ch\u1ea5t \u0111\u1ed1i kh\u00e1ng th\u1ee5 th\u1ec3 5-HT3 v\u1edbi t\u00e1c d\u1ee5ng ch\u1ed1ng n\u00f4n d\u01b0\u1edbi d\u1ea1ng thu\u1ed1c ti\u00eam t\u0129nh m\u1ea1ch (IV). rong nh\u1eefng n\u0103m qua, FDA \u0111\u00e3 ph\u00ea duy\u1ec7t th\u00eam nhi\u1ec1u d\u1ea1ng thu\u1ed1c u\u1ed1ng kh\u00e1c nhau<\/span><\/p>\n<figure id=\"attachment_30972\" aria-describedby=\"caption-attachment-30972\" style=\"width: 300px\" class=\"wp-caption aligncenter\"><img decoding=\"async\" loading=\"lazy\" class=\"size-medium wp-image-30972\" src=\"http:\/\/noithathoaphat.in\/ctv\/wp-content\/uploads\/2023\/05\/Ondansetron-Zofran-300x300.webp\" alt=\"Ondansetron (Zofran)\" width=\"300\" height=\"300\" srcset=\"http:\/\/noithathoaphat.in\/ctv\/wp-content\/uploads\/2023\/05\/Ondansetron-Zofran-300x300.webp 300w, http:\/\/noithathoaphat.in\/ctv\/wp-content\/uploads\/2023\/05\/Ondansetron-Zofran-150x150.webp 150w, http:\/\/noithathoaphat.in\/ctv\/wp-content\/uploads\/2023\/05\/Ondansetron-Zofran.webp 500w\" sizes=\"(max-width: 300px) 100vw, 300px\" \/><figcaption id=\"caption-attachment-30972\" class=\"wp-caption-text\">Ondansetron (Zofran)<\/figcaption><\/figure>\n<h3><span style=\"font-weight: 400;\">1.2 Nh\u00f3m d\u01b0\u1ee3c l\u00fd v\u00e0 ch\u1ec9 \u0111\u1ecbnh s\u1eed d\u1ee5ng\u00a0<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">Zofran (Ondansetron) l\u00e0 ch\u1ea5t \u0111\u1ed1i kh\u00e1ng th\u1ee5 th\u1ec3 5-HT3 \u0111\u01b0\u1ee3c ch\u1ec9 \u0111\u1ecbnh trong nh\u1eefng tr\u01b0\u1eddng h\u1ee3p<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Ph\u00f2ng ng\u1eeba bu\u1ed3n n\u00f4n v\u00e0 n\u00f4n li\u00ean quan \u0111\u1ebfn b\u1ec7nh ung th\u01b0\u00a0<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Bu\u1ed3n n\u00f4n v\u00e0 n\u00f4n li\u00ean quan \u0111\u1ebfn c\u00e1c \u0111\u1ee3t h\u00f3a tr\u1ecb li\u1ec7u ung th\u01b0 g\u00e2y n\u00f4n v\u1eeba ph\u1ea3i <\/span>ban \u0111\u1ea7u v\u00e0 l\u1eb7p l\u1ea1i<\/li>\n<li><span style=\"font-weight: 400;\">Bu\u1ed3n n\u00f4n v\u00e0 n\u00f4n li\u00ean quan \u0111\u1ebfn x\u1ea1 tr\u1ecb \u1edf nh\u1eefng b\u1ec7nh nh\u00e2n \u0111\u01b0\u1ee3c \u0111i\u1ec1u tr\u1ecb ho\u1eb7c chi\u1ebfu x\u1ea1 to\u00e0n b\u1ed9 c\u01a1 th\u1ec3\u00a0<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Bu\u1ed3n n\u00f4n v\u00e0\/ho\u1eb7c n\u00f4n sau ph\u1eabu thu\u1eadt\u00a0<\/span><\/li>\n<\/ul>\n<p><span style=\"font-weight: 400;\">Ondansetron n\u1eb1m trong Danh s\u00e1ch Thu\u1ed1c thi\u1ebft y\u1ebfu c\u1ee7a T\u1ed5 ch\u1ee9c Y t\u1ebf Th\u1ebf gi\u1edbi (WHO), danh s\u00e1ch c\u00e1c lo\u1ea1i thu\u1ed1c \u0111\u01b0\u1ee3c coi l\u00e0 hi\u1ec7u qu\u1ea3 v\u00e0 an to\u00e0n trong vi\u1ec7c \u0111\u00e1p \u1ee9ng c\u00e1c nhu c\u1ea7u thi\u1ebft y\u1ebfu c\u1ee7a h\u1ec7 th\u1ed1ng ch\u0103m s\u00f3c s\u1ee9c kh\u1ecfe<\/span><\/p>\n<h3><span style=\"font-weight: 400;\">1.3 C\u01a1 ch\u1ebf ho\u1ea1t \u0111\u1ed9ng\u00a0<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">Ondansetron l\u00e0 m\u1ed9t ch\u1ea5t \u0111\u1ed1i kh\u00e1ng th\u1ee5 th\u1ec3 serotonin 5-HT3 ch\u1ecdn l\u1ecdc \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng cho c\u00e1c \u0111\u1eb7c t\u00ednh ch\u1ed1ng n\u00f4n. \u0110\u00e2y l\u00e0 m\u1ed9t trong b\u1ed1n ch\u1ea5t \u0111\u1ed1i kh\u00e1ng th\u1ee5 th\u1ec3 serotonin 5-HT3 \u0111\u01b0\u1ee3c FDA ch\u1ea5p thu\u1eadn s\u1eed d\u1ee5ng \u0111\u1ec3 ch\u1ed1ng bu\u1ed3n n\u00f4n v\u00e0 n\u00f4n (Granisetron, Dolasetron, Palonosetron)<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Ondansetron t\u00e1c \u0111\u1ed9ng c\u1ea3 \u1edf trung \u01b0\u01a1ng v\u00e0 ngo\u1ea1i bi\u00ean \u0111\u1ec3 ng\u0103n ng\u1eeba v\u00e0 \u0111i\u1ec1u tr\u1ecb bu\u1ed3n n\u00f4n v\u00e0 n\u00f4n. C\u00e1c hi\u1ec7u \u1ee9ng trung t\u00e2m \u0111\u01b0\u1ee3c trung gian b\u1edfi s\u1ef1 \u0111\u1ed1i kh\u00e1ng c\u1ee7a c\u00e1c th\u1ee5 th\u1ec3 serotonin 5-HT3 trong v\u00f9ng postrema. V\u00f9ng n\u00e0y n\u1eb1m tr\u00ean t\u1ea7ng t\u00e2m th\u1ea5t th\u1ee9 t\u01b0, ch\u1ee9a &#8220;v\u00f9ng k\u00edch ho\u1ea1t th\u1ee5 th\u1ec3 h\u00f3a h\u1ecdc&#8221;, c\u1ea3m nh\u1eadn c\u00e1c ch\u1ea5t d\u1eabn truy\u1ec1n th\u1ea7n kinh (serotonin, ch\u1ea5t \u0111\u1ed9c,&#8230;), \u0111\u1ed3ng th\u1eddi \u0111\u00f3ng vai tr\u00f2 l\u00e0m trung gian c\u1ea3m gi\u00e1c bu\u1ed3n n\u00f4n v\u00e0 n\u00f4n sau \u0111\u00f3. Ondansetron c\u0169ng c\u00f3 t\u00e1c d\u1ee5ng ngo\u1ea1i vi b\u1eb1ng c\u00e1ch t\u00e1c \u0111\u1ed9ng l\u00ean th\u1ee5 th\u1ec3 5-HT3 tr\u00ean \u0111\u1ea7u d\u00e2y th\u1ea7n kinh ph\u1ebf v\u1ecb.\u00a0<\/span><\/p>\n<h3><span style=\"font-weight: 400;\">1.4 D\u01b0\u1ee3c \u0111\u1ed9ng h\u1ecdc<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">H\u1ea5p thu: Ondansetron h\u1ea5p thu nhanh qua \u0111\u01b0\u1eddng ti\u00eau h\u00f3a v\u00e0 n\u1ed3ng \u0111\u1ed9 \u0111\u1ec9nh trong huy\u1ebft t\u01b0\u01a1ng (Tmax) \u0111\u1ea1t \u0111\u01b0\u1ee3c kho\u1ea3ng 1,5 gi\u1edd sau khi u\u1ed1ng li\u1ec1u \u0111\u01a1n 8 mg. Sinh kh\u1ea3 d\u1ee5ng tuy\u1ec7t \u0111\u1ed1i khi u\u1ed1ng l\u00e0 60%. Sinh kh\u1ea3 d\u1ee5ng \u1edf b\u1ec7nh nh\u00e2n ung th\u01b0 (85% \u2013 87%) cao h\u01a1n \u0111\u00e1ng k\u1ec3 so v\u1edbi \u1edf ng\u01b0\u1eddi kh\u1ecfe m\u1ea1nh (50% \u2013 70%)<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Ph\u00e2n b\u1ed1: Ondansetron v\u00e0 c\u00e1c ch\u1ea5t chuy\u1ec3n h\u00f3a ph\u00e2n b\u1ed1 r\u1ed9ng r\u00e3i trong c\u00e1c m\u00f4. Th\u1ec3 t\u00edch ph\u00e2n b\u1ed1 (Vd) l\u00e0 1,8L\/kg.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Chuy\u1ec3n h\u00f3a: Gan l\u00e0 n\u01a1i chuy\u1ec3n h\u00f3a ch\u00ednh v\u1edbi c\u01a1 ch\u1ebf oxy h\u00f3a l\u00e0 ch\u1ee7 y\u1ebfu v\u00e0 c\u00f3 s\u1ef1 tham gia c\u1ee7a c\u00e1c enzyme chuy\u1ec3n h\u00f3a CYP1A2 quan tr\u1ecdng nh\u1ea5t c\u00f9ng v\u1edbi CYP2D6 \u0111\u00f3ng vai tr\u00f2 th\u1ee9 y\u1ebfu<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Th\u1ea3i tr\u1eeb: Chuy\u1ec3n h\u00f3a \u1edf gan chi\u1ebfm g\u1ea7n 95% \u0111\u1ed9 thanh th\u1ea3i v\u00e0 d\u01b0\u1edbi 5% \u0111\u01b0\u1ee3c b\u00e0i ti\u1ebft d\u01b0\u1edbi d\u1ea1ng kh\u00f4ng \u0111\u1ed5i qua n\u01b0\u1edbc ti\u1ec3u v\u1edbi th\u1eddi gian b\u00e1n th\u1ea3i sau khi d\u00f9ng li\u1ec1u 8mg u\u1ed1ng ho\u1eb7c ti\u00eam t\u0129nh m\u1ea1ch l\u00e0 kho\u1ea3ng 3-4 gi\u1edd. \u1ede ng\u01b0\u1eddi l\u1edbn, \u0111\u1ed9 thanh th\u1ea3i l\u00e0 0,3515L\/h\/kg<\/span><\/p>\n<h3><span style=\"font-weight: 400;\">1.5 T\u00e1c d\u1ee5ng ph\u1ee5\u00a0<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">C\u00e1c t\u00e1c d\u1ee5ng ph\u1ee5 \u0111\u01b0\u1ee3c b\u00e1o c\u00e1o ph\u1ed5 bi\u1ebfn nh\u1ea5t (x\u1ea3y ra \u1edf h\u01a1n 10% ng\u01b0\u1eddi l\u1edbn) bao g\u1ed3m nh\u1ee9c \u0111\u1ea7u, m\u1ec7t m\u1ecfi, kh\u00f4 mi\u1ec7ng, kh\u00f3 ch\u1ecbu v\u00e0 t\u00e1o b\u00f3n. M\u1ed9t s\u1ed1 t\u00e1c d\u1ee5ng \u00edt ph\u1ed5 bi\u1ebfn h\u01a1n bao g\u1ed3m t\u1eeb bi\u1ec3u hi\u1ec7n c\u1ee7a h\u1ec7 th\u1ea7n kinh trung \u01b0\u01a1ng (CNS), ch\u1eb3ng h\u1ea1n nh\u01b0 bu\u1ed3n ng\u1ee7 v\u00e0 an th\u1ea7n, \u0111\u1ebfn ph\u1ea3n \u1ee9ng t\u1ea1i ch\u1ed7 ti\u00eam v\u00e0 ng\u1ee9a<\/span><\/p>\n<h3><span style=\"font-weight: 400;\">1.6 Ch\u1ed1ng ch\u1ec9 \u0111\u1ecbnh\u00a0<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">Ondansetron ch\u1ed1ng ch\u1ec9 \u0111\u1ecbnh \u1edf nh\u1eefng b\u1ec7nh nh\u00e2n qu\u00e1 m\u1eabn c\u1ea3m v\u1edbi thu\u1ed1c ho\u1eb7c b\u1ea5t k\u1ef3 th\u00e0nh ph\u1ea7n n\u00e0o c\u1ee7a thu\u1ed1c, b\u1ec7nh nh\u00e2n hi\u1ec7n \u0111ang d\u00f9ng Apomorphine, b\u1ec7nh nh\u00e2n b\u1ecb phenylceton ni\u1ec7u (PKU)<\/span><\/p>\n<h2><strong>2.T\u00ecm hi\u1ec3u v\u1ec1 Dofetilide<\/strong><\/h2>\n<h3><span style=\"font-weight: 400;\">2.1 Gi\u1edbi thi\u1ec7u chung\u00a0<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">V\u00e0o th\u00e1ng 1 n\u0103m 2016, FDA \u0111\u00e3 x\u00e1c \u0111\u1ecbnh r\u1eb1ng m\u1eb7c d\u00f9 c\u00e1c r\u1ee7i ro v\u1ec1 an to\u00e0n \u0111\u1ed1i v\u1edbi Tikosyn (Dofetilide) v\u1eabn c\u00f2n t\u1ed3n t\u1ea1i nh\u01b0ng v\u1eabn hi\u1ec7u qu\u1ea3 trong \u0111i\u1ec1u tr\u1ecb r\u1ed1i lo\u1ea1n nh\u1ecbp tim\u00a0<\/span><\/p>\n<figure id=\"attachment_30973\" aria-describedby=\"caption-attachment-30973\" style=\"width: 300px\" class=\"wp-caption aligncenter\"><img decoding=\"async\" loading=\"lazy\" class=\"size-medium wp-image-30973\" src=\"http:\/\/noithathoaphat.in\/ctv\/wp-content\/uploads\/2023\/05\/Dofetilide-Tikosyn-300x254.jpg\" alt=\"Dofetilide (Tikosyn)\" width=\"300\" height=\"254\" srcset=\"http:\/\/noithathoaphat.in\/ctv\/wp-content\/uploads\/2023\/05\/Dofetilide-Tikosyn-300x254.jpg 300w, http:\/\/noithathoaphat.in\/ctv\/wp-content\/uploads\/2023\/05\/Dofetilide-Tikosyn.jpg 696w\" sizes=\"(max-width: 300px) 100vw, 300px\" \/><figcaption id=\"caption-attachment-30973\" class=\"wp-caption-text\">Dofetilide (Tikosyn)<\/figcaption><\/figure>\n<h3><span style=\"font-weight: 400;\">2.2 Nh\u00f3m d\u01b0\u1ee3c l\u00fd v\u00e0 ch\u1ec9 \u0111\u1ecbnh s\u1eed d\u1ee5ng\u00a0<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">Tikosyn (<a href=\"https:\/\/www.vinmec.com\/vi\/thong-tin-duoc\/su-dung-thuoc-toan\/tac-dung-cua-thuoc-dofetilide\/\">Dofetilide<\/a>) l\u00e0 thu\u1ed1c ch\u1ed1ng lo\u1ea1n nh\u1ecbp tim lo\u1ea1i III \u0111\u01b0\u1ee3c ch\u1ec9 \u0111\u1ecbnh \u0111\u1ec3 duy tr\u00ec nh\u1ecbp xoang b\u00ecnh th\u01b0\u1eddng (l\u00e0m ch\u1eadm th\u1eddi gian t\u00e1i ph\u00e1t rung nh\u0129 \/ cu\u1ed3ng nh\u0129) \u1edf b\u1ec7nh nh\u00e2n rung nh\u0129\/cu\u1ed3ng nh\u0129 k\u00e9o d\u00e0i h\u01a1n m\u1ed9t tu\u1ea7n \u0111\u00e3 \u0111\u01b0\u1ee3c chuy\u1ec3n v\u1ec1 nh\u1ecbp xoang b\u00ecnh th\u01b0\u1eddng v\u00e0 \u0111\u01b0\u1ee3c ch\u1ec9 \u0111\u1ecbnh \u0111\u1ec3 chuy\u1ec3n rung nh\u0129 v\u00e0 cu\u1ed3ng nh\u0129 v\u1ec1 nh\u1ecbp xoang b\u00ecnh th\u01b0\u1eddng.<\/span><\/p>\n<h3><span style=\"font-weight: 400;\">2.3 C\u01a1 ch\u1ebf ho\u1ea1t \u0111\u1ed9ng\u00a0<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">Dofetilide ng\u0103n ch\u1eb7n c\u00e1c k\u00eanh Kali trong giai \u0111o\u1ea1n 3 c\u1ee7a \u0111i\u1ec7n th\u1ebf ho\u1ea1t \u0111\u1ed9ng v\u00e0 l\u00e0m ch\u1eadm d\u00f2ng K+ tho\u00e1t ra kh\u1ecfi t\u1ebf b\u00e0o c\u01a1 l\u00e0m ch\u1eadm t\u1ed1c \u0111\u1ed9 t\u00e1i c\u1ef1c c\u1ee7a t\u1ebf b\u00e0o v\u00e0 k\u00e9o d\u00e0i giai \u0111o\u1ea1n \u1ed5n \u0111\u1ecbnh c\u1ee7a \u0111i\u1ec7n th\u1ebf ho\u1ea1t \u0111\u1ed9ng. Giai \u0111o\u1ea1n tr\u01a1 c\u1ee7a t\u00e2m nh\u0129, t\u00e2m th\u1ea5t v\u00e0 t\u1ebf b\u00e0o Purkinje t\u0103ng l\u00ean, d\u1eabn \u0111\u1ebfn k\u00e9o d\u00e0i kho\u1ea3ng QT tr\u00ean ECG. Do \u0111\u00f3, Dofetilide l\u00e0m t\u0103ng th\u1eddi gian tr\u01a1 hi\u1ec7u qu\u1ea3 v\u00e0 \u0111i\u1ec7n th\u1ebf ho\u1ea1t \u0111\u1ed9ng m\u00e0 kh\u00f4ng \u1ea3nh h\u01b0\u1edfng \u0111\u1ebfn t\u1ed1c \u0111\u1ed9 d\u1eabn truy\u1ec1n<\/span><\/p>\n<h3><span style=\"font-weight: 400;\">2.4 D\u01b0\u1ee3c \u0111\u1ed9ng h\u1ecdc\u00a0<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">H\u1ea5p thu: Dofetilide h\u1ea5p thu g\u1ea7n nh\u01b0 100% qua \u0111\u01b0\u1eddng u\u1ed1ng. Sinh kh\u1ea3 d\u1ee5ng \u0111\u01b0\u1eddng u\u1ed1ng kh\u00f4ng b\u1ecb \u1ea3nh h\u01b0\u1edfng b\u1edfi th\u1ee9c \u0103n ho\u1eb7c thu\u1ed1c kh\u00e1ng acid. N\u1ed3ng \u0111\u1ed9 trong huy\u1ebft t\u01b0\u01a1ng \u1edf tr\u1ea1ng th\u00e1i \u1ed5n \u0111\u1ecbnh c\u00f3 th\u1ec3 \u0111\u1ea1t \u0111\u01b0\u1ee3c trong v\u00f2ng 2 \u0111\u1ebfn 3 ng\u00e0y v\u00e0 t\u1ec9 l\u1ec7 thu\u1eadn v\u1edbi li\u1ec1u d\u00f9ng<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Ph\u00e2n b\u1ed1: Th\u1ec3 t\u00edch ph\u00e2n b\u1ed1 (Vd) n\u1eb1m trong kho\u1ea3ng 3,1L\/kg \u0111\u1ebfn 4,0L\/kg. S\u1ef1 g\u1eafn k\u1ebft v\u1edbi protein huy\u1ebft t\u01b0\u01a1ng c\u1ee7a Dofetilide l\u00e0 60% \u0111\u1ebfn 70%, kh\u00f4ng ph\u1ee5 thu\u1ed9c v\u00e0o n\u1ed3ng \u0111\u1ed9 trong huy\u1ebft t\u01b0\u01a1ng v\u00e0 kh\u00f4ng b\u1ecb \u1ea3nh h\u01b0\u1edfng b\u1edfi suy th\u1eadn<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Chuy\u1ec3n h\u00f3a: 50% Dofetilide \u0111\u01b0\u1ee3c chuy\u1ec3n h\u00f3a \u1edf gan th\u00e0nh c\u00e1c ch\u1ea5t kh\u00f4ng ho\u1ea1t \u0111\u1ed9ng. Dofetilide \u0111\u01b0\u1ee3c chuy\u1ec3n h\u00f3a 1 ph\u1ea7n b\u1edfi enzyme CYP3A4 c\u1ee7a h\u1ec7 th\u1ed1ng cytochrom P450<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Th\u1ea3i tr\u1eeb: Kho\u1ea3ng 80% li\u1ec1u \u0111\u01a1n thu\u1ed1c Dofetilide \u0111\u01b0\u1ee3c b\u00e0i ti\u1ebft qua n\u01b0\u1edbc ti\u1ec3u b\u1eb1ng c\u00e1ch b\u00e0i ti\u1ebft cation v\u1edbi th\u1eddi gian b\u00e1n th\u1ea3i t\u1eeb 4,8 \u0111\u1ebfn 13,5 gi\u1edd<\/span><\/p>\n<h3><span style=\"font-weight: 400;\">2.5 T\u00e1c d\u1ee5ng ph\u1ee5\u00a0<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">Dofetilide c\u00f3 th\u1ec3 g\u00e2y ra ho\u1eb7c l\u00e0m tr\u1ea7m tr\u1ecdng th\u00eam ch\u1ee9ng lo\u1ea1n nh\u1ecbp th\u1ea5t khi s\u1eed d\u1ee5ng trong \u0111i\u1ec1u tr\u1ecb, t\u1ea1o ra nh\u1ecbp nhanh th\u1ea5t \u0111e d\u1ecda t\u00ednh m\u1ea1ng. C\u00e1c t\u00e1c d\u1ee5ng ph\u1ee5 ti\u1ec1m \u1ea9n kh\u00e1c bao g\u1ed3m \u0111au ng\u1ef1c, bu\u1ed3n n\u00f4n, \u0111au b\u1ee5ng, \u0111\u1ea7y h\u01a1i, ti\u00eau ch\u1ea3y, nh\u1ee9c \u0111\u1ea7u, ch\u00f3ng m\u1eb7t, m\u1ec7t m\u1ecfi, k\u00e9o d\u00e0i kho\u1ea3ng QT, xo\u1eafn \u0111\u1ec9nh v\u00e0 block tim ho\u00e0n to\u00e0n. Trong \u0111\u00f3, c\u00e1c t\u00e1c d\u1ee5ng ph\u1ee5 ph\u1ed5 bi\u1ebfn nh\u1ea5t l\u00e0 \u0111au \u0111\u1ea7u, \u0111au ng\u1ef1c v\u00e0 ch\u00f3ng m\u1eb7t<\/span><\/p>\n<h3><span style=\"font-weight: 400;\">2.6 Ch\u1ed1ng ch\u1ec9 \u0111\u1ecbnh\u00a0<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">Dofetilide ch\u1ed1ng ch\u1ec9 \u0111\u1ecbnh \u1edf b\u1ec7nh nh\u00e2n m\u1eafc h\u1ed9i ch\u1ee9ng QT d\u00e0i, c\u00f3 n\u1ed3ng \u0111\u1ed9 Kali th\u1ea5p trong m\u00e1u, n\u00f4n m\u1eeda v\u00e0\/ho\u1eb7c ti\u00eau ch\u1ea3y, \u0111\u1ed5 m\u1ed3 h\u00f4i, ch\u00e1n \u0103n, t\u1eebng m\u1eafc b\u1ec7nh tim ho\u1eb7c gan, d\u1ef1 \u0111\u1ecbnh c\u00f3 thai, \u0111ang mang thai, ho\u1eb7c \u0111ang cho con b\u00fa<\/span><\/p>\n<h2><strong>3.T\u01b0\u01a1ng t\u00e1c gi\u1eefa Ondansetron v\u00e0 Dofetilide\u00a0<\/strong><\/h2>\n<h3><span style=\"font-weight: 400;\">3.1 M\u1ee9c \u0111\u1ed9 t\u01b0\u01a1ng t\u00e1c t\u1eeb nhi\u1ec1u ngu\u1ed3n kh\u00e1c nhau\u00a0<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">Medscape interaction checker: Nghi\u00eam tr\u1ecdng\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Drugs.com: Nghi\u00eam tr\u1ecdng\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Lexicomp: Nghi\u00eam tr\u1ecdng\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Micromedex interaction: Nghi\u00eam tr\u1ecdng\u00a0<\/span><\/p>\n<h3><span style=\"font-weight: 400;\">3.2 C\u01a1 ch\u1ebf t\u01b0\u01a1ng t\u00e1c\u00a0<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">C\u01a1 ch\u1ebf t\u01b0\u01a1ng t\u00e1c gi\u1eefa Dofetilide v\u00e0 Ondansetron l\u00e0 m\u1ed9t t\u01b0\u01a1ng t\u00e1c d\u01b0\u1ee3c l\u1ef1c h\u1ecdc. C\u1ea3 hai lo\u1ea1i thu\u1ed1c \u0111\u1ec1u c\u00f3 t\u00e1c d\u1ee5ng \u1ee9c ch\u1ebf k\u00eanh ion Kali trong tim, v\u00e0 khi \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng c\u00f9ng nhau, ch\u00fang c\u00f3 th\u1ec3 l\u00e0m t\u0103ng nguy c\u01a1 nh\u1ecbp tim kh\u00f4ng \u0111\u1ec1u v\u00e0 c\u00f3 th\u1ec3 nghi\u00eam tr\u1ecdng, g\u00e2y \u0111e d\u1ecda t\u00ednh m\u1ea1ng<\/span><\/p>\n<h3><span style=\"font-weight: 400;\">3.3 H\u1eadu qu\u1ea3 v\u00e0 h\u01b0\u1edbng x\u1eed tr\u00ed\u00a0<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">T\u01b0\u01a1ng t\u00e1c gi\u1eefa Dofetilide v\u00e0 Ondansetron c\u00f3 th\u1ec3 g\u00e2y ra c\u00e1c t\u00e1c d\u1ee5ng ph\u1ee5 nghi\u00eam tr\u1ecdng, bao g\u1ed3m:<\/span><\/p>\n<p><span style=\"font-weight: 400;\">(1) T\u0103ng nguy c\u01a1 nh\u1ecbp tim kh\u00f4ng \u0111\u1ec1u: C\u1ea3 Dofetilide v\u00e0 Ondansetron \u0111\u1ec1u c\u00f3 t\u00e1c d\u1ee5ng \u1ee9c ch\u1ebf k\u00eanh ion kali trong tim. Khi \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng c\u00f9ng nhau, ch\u00fang c\u00f3 th\u1ec3 l\u00e0m t\u0103ng nguy c\u01a1 nh\u1ecbp tim kh\u00f4ng \u0111\u1ec1u, nh\u1ea5t l\u00e0 \u1edf nh\u1eefng ng\u01b0\u1eddi c\u00f3 b\u1ec7nh tim li\u00ean quan. C\u00e1c tri\u1ec7u ch\u1ee9ng bao g\u1ed3m tim \u0111\u1eadp nhanh, ch\u00f3ng m\u1eb7t, ch\u00f3ng m\u1eb7t, ho\u1eb7c ng\u1ea5t x\u1ec9u.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">(2) R\u1ed1i lo\u1ea1n \u0111i\u1ec7n gi\u1ea3i: T\u01b0\u01a1ng t\u00e1c gi\u1eefa Dofetilide v\u00e0 Ondansetron c\u0169ng c\u00f3 th\u1ec3 g\u00e2y ra r\u1ed1i lo\u1ea1n \u0111i\u1ec7n gi\u1ea3i trong tim, d\u1eabn \u0111\u1ebfn c\u00e1c tri\u1ec7u ch\u1ee9ng nh\u01b0 tim \u0111\u1eadp nhanh, ch\u00f3ng m\u1eb7t, ho\u1eb7c ng\u1ea5t x\u1ec9u.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">(3) T\u00e1c d\u1ee5ng ph\u1ee5 kh\u00e1c: Ngo\u00e0i ra, Dofetilide v\u00e0 Ondansetron c\u0169ng c\u00f3 th\u1ec3 g\u00e2y ra c\u00e1c t\u00e1c d\u1ee5ng ph\u1ee5 kh\u00e1c nh\u01b0 bu\u1ed3n n\u00f4n, \u0111au \u0111\u1ea7u, ch\u00f3ng m\u1eb7t, kh\u00f3 th\u1edf, ho\u1eb7c gi\u1ea3m \u00e1p l\u1ef1c m\u00e1u<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Do \u0111\u00f3, n\u1ebfu b\u1ec7nh nh\u00e2n \u0111\u01b0\u1ee3c ch\u1ec9 \u0111\u1ecbnh s\u1eed d\u1ee5ng c\u1ea3 Dofetilide v\u00e0 Ondansetron, b\u00e1c s\u0129 c\u1ea7n c\u00e2n nh\u1eafc v\u00e0 \u0111\u00e1nh gi\u00e1 r\u1ee7i ro v\u00e0 l\u1ee3i \u00edch c\u1ee7a vi\u1ec7c s\u1eed d\u1ee5ng c\u1ea3 hai lo\u1ea1i thu\u1ed1c. B\u00e1c s\u0129 c\u0169ng c\u1ea7n th\u1ef1c hi\u1ec7n c\u00e1c bi\u1ec7n ph\u00e1p ph\u00f2ng ng\u1eeba th\u00edch h\u1ee3p v\u00e0 theo d\u00f5i b\u1ec7nh nh\u00e2n ch\u1eb7t ch\u1ebd \u0111\u1ec3 ph\u00e1t hi\u1ec7n k\u1ecbp th\u1eddi b\u1ea5t k\u1ef3 bi\u1ebfn ch\u1ee9ng n\u00e0o c\u00f3 th\u1ec3 x\u1ea3y ra<\/span><\/p>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>T\u01b0\u01a1ng t\u00e1c thu\u1ed1c l\u00e0 hi\u1ec7n t\u01b0\u1ee3ng khi hai ho\u1eb7c nhi\u1ec1u lo\u1ea1i thu\u1ed1c \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng c\u00f9ng nhau v\u00e0 t\u00e1c \u0111\u1ed9ng l\u00ean nhau trong c\u01a1 th\u1ec3. T\u01b0\u01a1ng t\u00e1c n\u00e0y c\u00f3 th\u1ec3 \u1ea3nh h\u01b0\u1edfng \u0111\u1ebfn hi\u1ec7u qu\u1ea3 \u0111i\u1ec1u tr\u1ecb ho\u1eb7c g\u00e2y ra c\u00e1c t\u00e1c d\u1ee5ng ph\u1ee5 nghi\u00eam tr\u1ecdng. M\u1ed9t trong nh\u1eefng t\u01b0\u01a1ng t\u00e1c thu\u1ed1c ti\u1ec1m n\u0103ng l\u00e0 [&hellip;]<\/p>\n","protected":false},"author":54,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[12],"tags":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v20.4 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>T\u01b0\u01a1ng t\u00e1c thu\u1ed1c gi\u1eefa Ondansetron v\u00e0 Dofetilide - Vinmec<\/title>\n<meta name=\"description\" content=\"Ondansetron v\u00e0 Dofetilide khi \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng chung c\u00f9ng l\u00fac v\u1edbi nhau l\u00e0m t\u0103ng nguy c\u01a1 x\u1ea3y ra t\u00e1c d\u1ee5ng ph\u1ee5 \u1ea3nh h\u01b0\u1edfng nghi\u00eam tr\u1ecdng \u0111\u1ebfn b\u1ec7nh nh\u00e2n\" \/>\n<meta name=\"robots\" content=\"noindex, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"T\u01b0\u01a1ng t\u00e1c thu\u1ed1c gi\u1eefa Ondansetron v\u00e0 Dofetilide - 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