{"id":30343,"date":"2023-05-02T11:44:24","date_gmt":"2023-05-02T04:44:24","guid":{"rendered":"http:\/\/noithathoaphat.in\/ctv\/?p=30343"},"modified":"2023-05-02T11:44:24","modified_gmt":"2023-05-02T04:44:24","slug":"phuong-phap-dung-thuoc-dieu-tri-soi-mat","status":"publish","type":"post","link":"http:\/\/noithathoaphat.in\/ctv\/index.php\/2023\/05\/02\/phuong-phap-dung-thuoc-dieu-tri-soi-mat\/","title":{"rendered":"Ph\u01b0\u01a1ng ph\u00e1p d\u00f9ng thu\u1ed1c \u0111i\u1ec1u tr\u1ecb s\u1ecfi m\u1eadt"},"content":{"rendered":"

S\u1ecfi m\u1eadt l\u00e0 m\u1ed9t c\u0103n b\u1ec7nh kh\u00e1 ph\u1ed5 bi\u1ebfn v\u00e0 c\u00f3 th\u1ec3 g\u00e2y ra nhi\u1ec1u bi\u1ebfn ch\u1ee9ng n\u1ebfu kh\u00f4ng \u0111\u01b0\u1ee3c \u0111i\u1ec1u tr\u1ecb k\u1ecbp th\u1eddi v\u00e0 hi\u1ec7u qu\u1ea3. Hi\u1ec7n nay, \u0111\u00e3 c\u00f3 nhi\u1ec1u ph\u01b0\u01a1ng ph\u00e1p \u0111i\u1ec1u tr\u1ecb s\u1ecfi m\u1eadt, trong \u0111\u00f3 ph\u01b0\u01a1ng ph\u00e1p d\u00f9ng thu\u1ed1c l\u00e0 m\u1ed9t trong nh\u1eefng thu\u1ed1c \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng ph\u1ed5 bi\u1ebfn<\/strong><\/p>\n

1.T\u00ecm hi\u1ec3u v\u1ec1 s\u1ecfi m\u1eadt<\/strong><\/h2>\n

S\u1ecfi m\u1eadt<\/a> h\u00ecnh th\u00e0nh khi m\u1eadt \u0111\u01b0\u1ee3c l\u01b0u tr\u1eef trong t\u00fai m\u1eadt c\u1ee9ng l\u1ea1i nh\u01b0 \u0111\u00e1. Qu\u00e1 nhi\u1ec1u cholesterol, mu\u1ed1i m\u1eadt ho\u1eb7c bilirubin (s\u1eafc t\u1ed1 m\u1eadt) c\u00f3 th\u1ec3 t\u1ea1o ra s\u1ecfi. Khi s\u1ecfi n\u1eb1m trong t\u00fai m\u1eadt, g\u1ecdi l\u00e0 s\u1ecfi m\u1eadt. Khi s\u1ecfi c\u00f3 trong \u1ed1ng d\u1eabn m\u1eadt, n\u00f3 \u0111\u01b0\u1ee3c g\u1ecdi l\u00e0 s\u1ecfi t\u00fai m\u1eadt. S\u1ecfi m\u1eadt l\u00e0m t\u1eafc ngh\u1ebdn \u1ed1ng d\u1eabn m\u1eadt c\u00f3 th\u1ec3 d\u1eabn \u0111\u1ebfn nhi\u1ec5m tr\u00f9ng n\u1eb7ng ho\u1eb7c nhi\u1ec5m tr\u00f9ng tuy\u1ebfn t\u1ee5y ho\u1eb7c gan<\/span><\/p>\n

\"S\u1ecfi
S\u1ecfi m\u1eadt<\/figcaption><\/figure>\n

Nguy\u00ean nh\u00e2n g\u00e2y ra s\u1ecfi m\u1eadt: S\u1ecfi cholesterol \u0111\u01b0\u1ee3c cho l\u00e0 h\u00ecnh th\u00e0nh khi m\u1eadt ch\u1ee9a qu\u00e1 nhi\u1ec1u cholesterol, qu\u00e1 nhi\u1ec1u bilirubin, kh\u00f4ng \u0111\u1ee7 mu\u1ed1i m\u1eadt ho\u1eb7c khi t\u00fai m\u1eadt kh\u00f4ng r\u1ed7ng nh\u01b0 b\u00ecnh th\u01b0\u1eddng. S\u1ecfi s\u1eafc t\u1ed1 c\u00f3 xu h\u01b0\u1edbng ph\u00e1t tri\u1ec3n \u1edf nh\u1eefng ng\u01b0\u1eddi b\u1ecb x\u01a1 gan, nhi\u1ec5m tr\u00f9ng \u0111\u01b0\u1eddng m\u1eadt v\u00e0 r\u1ed1i lo\u1ea1n m\u00e1u di truy\u1ec1n nh\u01b0 thi\u1ebfu m\u00e1u h\u1ed3ng c\u1ea7u h\u00ecnh li\u1ec1m.<\/span><\/p>\n

L\u00fac \u0111\u1ea7u, h\u1ea7u h\u1ebft s\u1ecfi m\u1eadt kh\u00f4ng g\u00e2y ra tri\u1ec7u ch\u1ee9ng. Tuy nhi\u00ean, khi s\u1ecfi m\u1eadt tr\u1edf n\u00ean l\u1edbn h\u01a1n ho\u1eb7c khi ch\u00fang b\u1eaft \u0111\u1ea7u l\u00e0m t\u1eafc ngh\u1ebdn \u1ed1ng d\u1eabn m\u1eadt, c\u00e1c tri\u1ec7u ch\u1ee9ng b\u1eaft \u0111\u1ea7u xu\u1ea5t hi\u1ec7n. C\u00e1c bi\u1ec3u hi\u1ec7n r\u00f5 r\u00e0ng h\u01a1n sau b\u1eefa \u0103n nhi\u1ec1u ch\u1ea5t b\u00e9o v\u00e0 v\u00e0o ban \u0111\u00eam. C\u00e1c tri\u1ec7u ch\u1ee9ng c\u00f3 th\u1ec3 bao g\u1ed3m: c\u01a1n \u0111au d\u1eef d\u1ed9i, dai d\u1eb3ng \u1edf v\u00f9ng b\u1ee5ng tr\u00ean t\u0103ng nhanh v\u00e0 c\u00f3 th\u1ec3 k\u00e9o d\u00e0i t\u1eeb 30 ph\u00fat \u0111\u1ebfn v\u00e0i gi\u1edd, \u0111au l\u01b0ng gi\u1eefa hai b\u1ea3 vai, \u0111au \u1edf vai ph\u1ea3i, bu\u1ed3n n\u00f4n, n\u00f4n m\u1eeda, s\u1ed1t, \u1edbn l\u1ea1nh, v\u00e0ng da, \u0111\u1ea7y b\u1ee5ng, \u1ee3 h\u01a1i ho\u1eb7c \u0111\u1ea7y h\u01a1i, kh\u00f3 ti\u00eau, \u0111\u1ed5 m\u1ed3 h\u00f4i. M\u1ed9t s\u1ed1 ng\u01b0\u1eddi b\u1ecb s\u1ecfi m\u1eadt kh\u00f4ng c\u00f3 b\u1ea5t k\u1ef3 tri\u1ec7u ch\u1ee9ng n\u00e0o.\u00a0<\/span><\/p>\n

C\u00e1c y\u1ebfu t\u1ed1 nguy c\u01a1 cho di\u1ec5n ti\u1ebfn nhanh cho t\u00ecnh tr\u1ea1ng s\u1ecfi m\u1eadt: (1) b\u00e9o ph\u00ec l\u00e0 m\u1ed9t y\u1ebfu t\u1ed1 nguy c\u01a1 ch\u00ednh g\u00e2y s\u1ecfi m\u1eadt, \u0111\u1eb7c bi\u1ec7t l\u00e0 \u1edf ph\u1ee5 n\u1eef, (2) d\u01b0 th\u1eeba Estrogen do mang thai l\u00e0m t\u0103ng m\u1ee9c cholesterol trong m\u1eadt v\u00e0 gi\u1ea3m chuy\u1ec3n \u0111\u1ed9ng c\u1ee7a t\u00fai m\u1eadt, (3) ng\u01b0\u1eddi M\u1ef9 b\u1ea3n \u0111\u1ecba c\u00f3 t\u1ef7 l\u1ec7 s\u1ecfi m\u1eadt cao nh\u1ea5t, (4) ph\u1ee5 n\u1eef c\u00f3 kh\u1ea3 n\u0103ng ph\u00e1t tri\u1ec3n s\u1ecfi m\u1eadt cao g\u1ea5p \u0111\u00f4i so v\u1edbi nam gi\u1edbi, (5) nh\u1eefng ng\u01b0\u1eddi tr\u00ean 60 tu\u1ed5i c\u00f3 nhi\u1ec1u kh\u1ea3 n\u0103ng b\u1ecb s\u1ecfi m\u1eadt h\u01a1n nh\u1eefng ng\u01b0\u1eddi tr\u1ebb tu\u1ed5i, (6) nh\u1eefng ng\u01b0\u1eddi m\u1eafc b\u1ec7nh ti\u1ec3u \u0111\u01b0\u1eddng th\u01b0\u1eddng c\u00f3 h\u00e0m l\u01b0\u1ee3ng acid b\u00e9o cao, \u0111\u01b0\u1ee3c g\u1ecdi l\u00e0 ch\u1ea5t b\u00e9o trung t\u00ednh, l\u00e0m t\u0103ng nguy c\u01a1 s\u1ecfi m\u1eadt, (7) nh\u1ecbn \u0103n l\u00e0m gi\u1ea3m chuy\u1ec3n \u0111\u1ed9ng c\u1ee7a t\u00fai m\u1eadt, khi\u1ebfn m\u1eadt tr\u1edf n\u00ean c\u00f4 \u0111\u1eb7c qu\u00e1 m\u1ee9c v\u1edbi Cholesterol, (8) khi c\u01a1 th\u1ec3 chuy\u1ec3n h\u00f3a ch\u1ea5t b\u00e9o trong qu\u00e1 tr\u00ecnh gi\u1ea3m c\u00e2n nhanh ch\u00f3ng khi\u1ebfn gan ti\u1ebft th\u00eam Cholesterol v\u00e0o m\u1eadt g\u00e2y s\u1ecfi m\u1eadt\u00a0<\/span><\/p>\n

Trong m\u1ed9t s\u1ed1 tr\u01b0\u1eddng h\u1ee3p, s\u1ecfi m\u1eadt kh\u00f4ng c\u00f3 tri\u1ec7u ch\u1ee9ng \u0111\u01b0\u1ee3c ph\u00e1t hi\u1ec7n trong qu\u00e1 tr\u00ecnh x\u00e9t nghi\u1ec7m. Tuy nhi\u00ean, khi c\u01a1n \u0111au k\u00e9o d\u00e0i ho\u1eb7c x\u1ea3y ra l\u1eb7p \u0111i l\u1eb7p l\u1ea1i c\u00f3 th\u1ec3 ki\u1ec3m tra s\u1ee9c kh\u1ecfe v\u00e0 th\u1ef1c hi\u1ec7n c\u00e1c th\u1ee7 t\u1ee5c ch\u1ea9n \u0111o\u00e1n s\u1ecfi m\u1eadt bao g\u1ed3m: si\u00eau \u00e2m, ch\u1ee5p X-quang, x\u00e9t nghi\u1ec7m m\u00e1u, ch\u1ee5p CT ho\u1eb7c CAT, n\u1ed9i soi m\u1eadt t\u1ee5y ng\u01b0\u1ee3c d\u00f2ng, c\u1eaft c\u01a1 v\u00f2ng<\/span><\/p>\n

N\u1ebfu s\u1ecfi m\u1eadt kh\u00f4ng g\u00e2y tri\u1ec7u ch\u1ee9ng th\u00ec th\u01b0\u1eddng kh\u00f4ng c\u1ea7n \u0111i\u1ec1u tr\u1ecb. Tuy nhi\u00ean, n\u1ebfu c\u01a1n \u0111au k\u00e9o d\u00e0i, ph\u01b0\u01a1ng ph\u00e1p \u0111i\u1ec1u tr\u1ecb g\u1ed3m: c\u1eaft b\u1ecf t\u00fai m\u1eadt (sau khi lo\u1ea1i b\u1ecf, m\u1eadt ch\u1ea3y tr\u1ef1c ti\u1ebfp t\u1eeb gan \u0111\u1ebfn ru\u1ed9t non), li\u1ec7u ph\u00e1p h\u00f2a tan b\u1eb1ng mi\u1ec7ng (thu\u1ed1c l\u00e0m t\u1eeb acid m\u1eadt l\u00e0m tan s\u1ecfi), ti\u00eam dung d\u1ecbch Metyl-tert-butyl ete v\u00e0o t\u00fai m\u1eadt l\u00e0m tan s\u1ecfi, t\u00e1n s\u1ecfi ngo\u00e0i c\u01a1 th\u1ec3 b\u1eb1ng s\u00f3ng xung k\u00edch (ESWL)<\/span><\/p>\n

2.C\u00e1c thu\u1ed1c s\u1eed d\u1ee5ng \u0111i\u1ec1u tr\u1ecb s\u1ecfi m\u1eadt<\/strong><\/h2>\n

2.1 Th\u00f4ng\u00a0 <\/span>tin v\u1ec1 thu\u1ed1c Actigall (Ursodiol)<\/a><\/span><\/h3>\n

Ursodiol l\u1ea7n \u0111\u1ea7u ti\u00ean \u0111\u01b0\u1ee3c FDA ch\u1ea5p thu\u1eadn v\u00e0o n\u0103m 1987 \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng \u0111\u1ec3 h\u00f2a tan m\u1ed9t s\u1ed1 lo\u1ea1i s\u1ecfi m\u1eadt , \u0111\u1ec3 ng\u0103n ng\u1eeba s\u1ecfi m\u1eadt h\u00ecnh th\u00e0nh \u1edf nh\u1eefng b\u1ec7nh nh\u00e2n b\u00e9o ph\u00ec \u0111ang gi\u1ea3m c\u00e2n nhanh ch\u00f3ng v\u00e0 \u0111\u1ec3 \u0111i\u1ec1u tr\u1ecb m\u1ed9t s\u1ed1 lo\u1ea1i b\u1ec7nh gan (vi\u00eam \u0111\u01b0\u1eddng m\u1eadt nguy\u00ean ph\u00e1t).<\/p>\n

\"Actigall
Actigall (Ursodiol)<\/figcaption><\/figure>\n

V\u1ecb tr\u00ed t\u00e1c d\u1ee5ng \u0111i\u1ec1u tr\u1ecb c\u1ee7a Ursodiol l\u00e0 \u1edf gan, m\u1eadt v\u00e0 l\u00f2ng ru\u1ed9t. \u1ede li\u1ec1u k\u00e9o d\u00e0i 13\u201315 mg\/kg\/ng\u00e0y, Ursodiol chi\u1ebfm kho\u1ea3ng 30\u201350% t\u1ed5ng l\u01b0\u1ee3ng axit m\u1eadt trong m\u1eadt v\u00e0 huy\u1ebft t\u01b0\u01a1ng.C\u01a1 ch\u1ebf h\u00f2a tan s\u1ecfi m\u1eadt: Ursodiol l\u00e0m gi\u1ea3m h\u00e0m l\u01b0\u1ee3ng Cholesterol trong m\u1eadt v\u00e0 s\u1ecfi m\u1eadt li\u00ean quan b\u1eb1ng c\u00e1ch gi\u1ea3m t\u1ed5ng h\u1ee3p v\u00e0 b\u00e0i ti\u1ebft Cholesterol \u1edf gan v\u00e0 gi\u1ea3m t\u00e1i h\u1ea5p thu m\u1ed9t ph\u1ea7n Cholesterol \u1edf ru\u1ed9t. Ursodiol kh\u00f4ng \u1ee9c ch\u1ebf s\u1ef1 t\u1ed5ng h\u1ee3p v\u00e0 b\u00e0i ti\u1ebft axit m\u1eadt ho\u1eb7c phospholipid n\u1ed9i sinh v\u00e0o m\u1eadt. Ngo\u00e0i vi\u1ec7c h\u00f2a tan Cholesterol trong mixen, Ursodiol g\u00e2y ra s\u1ef1 ph\u00e2n t\u00e1n cholesterol d\u01b0\u1edbi d\u1ea1ng tinh th\u1ec3 l\u1ecfng trong m\u00f4i tr\u01b0\u1eddng n\u01b0\u1edbc v\u00e0 l\u00e0m thay \u0111\u1ed5i b\u1ea3n ch\u1ea5t c\u1ee7a m\u1eadt t\u1eeb k\u1ebft t\u1ee7a Cholesterol sang h\u00f2a tan Cholesterol t\u1ea1o thu\u1eadn l\u1ee3i cho vi\u1ec7c h\u00f2a tan s\u1ecfi m\u1eadt.\u00a0<\/span><\/p>\n

Ursodiol \u0111\u01b0\u1ee3c d\u00f9ng b\u1eb1ng \u0111\u01b0\u1eddng u\u1ed1ng. Sau khi u\u1ed1ng, ph\u1ea7n l\u1edbn Ursodiol \u0111\u01b0\u1ee3c h\u1ea5p thu b\u1eb1ng c\u00e1ch khu\u1ebfch t\u00e1n th\u1ee5 \u0111\u1ed9ng v\u00e0 h\u1ea5p thu ho\u00e0n to\u00e0n. Trong qu\u00e1 tr\u00ecnh s\u1eed d\u1ee5ng l\u00e2u d\u00e0i Ursodiol, thu\u1ed1c tr\u1edf th\u00e0nh acid m\u1eadt ch\u1ee7 y\u1ebfu trong m\u1eadt v\u00e0 huy\u1ebft t\u01b0\u01a1ng v\u1edbi li\u1ec1u k\u00e9o d\u00e0i t\u1eeb 13 \u2013 15 mg\/kg\/ng\u00e0y, Ursodiol chi\u1ebfm 30 \u2013 50% acid m\u1eadt trong m\u1eadt v\u00e0 huy\u1ebft t\u01b0\u01a1ng. Th\u1ec3 t\u00edch ph\u00e2n b\u1ed1 (Vd) c\u1ee7a Ursodiol nh\u1ecf v\u00ec thu\u1ed1c ch\u1ee7 y\u1ebfu \u0111\u01b0\u1ee3c ph\u00e2n b\u1ed1 trong m\u1eadt \u1edf t\u00fai m\u1eadt v\u00e0 ru\u1ed9t non. Ursodiol kh\u00f4ng li\u00ean quan \u0111\u1ebfn s\u1ef1 g\u1eafn k\u1ebft v\u1edbi protein huy\u1ebft t\u01b0\u01a1ng. Ursodiol \u0111\u01b0\u1ee3c b\u00e0i ti\u1ebft ch\u1ee7 y\u1ebfu qua \u0111\u01b0\u1eddng ph\u00e2n v\u00e0 m\u1ed9t ph\u1ea7n qua \u0111\u01b0\u1eddng ni\u1ec7u v\u1edbi th\u1eddi gian b\u00e1n th\u1ea3i (T1\/2) \u01b0\u1edbc t\u00ednh n\u1eb1m trong kho\u1ea3ng 3,5 \u2013 5,8 ng\u00e0y.\u00a0<\/span><\/p>\n

Ursodiol khi \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng c\u00f3 nh\u1eefng t\u00e1c d\u1ee5ng ph\u1ee5 x\u1ea3y ra nh\u01b0 \u0111au d\u1ea1 d\u00e0y, bu\u1ed3n n\u00f4n, ti\u00eau ch\u1ea3y, ch\u00f3ng m\u1eb7t, \u0111au l\u01b0ng, r\u1ee5ng t\u00f3c ho\u1eb7c ho<\/span><\/p>\n

Ursodiol ch\u1ed1ng ch\u1ec9 \u0111\u1ecbnh s\u1eed d\u1ee5ng \u1edf nh\u1eefng b\u1ec7nh nh\u00e2n c\u00f3 s\u1ecfi s\u1eafc t\u1ed1 m\u1eadt c\u1ea3n quang ho\u1eb7c s\u1ecfi Cholesterol b\u1ecb v\u00f4i h\u00f3a, ph\u1ea3i c\u1eaft b\u1ecf t\u00fai m\u1eadt v\u00ec vi\u00eam t\u00fai m\u1eadt c\u1ea5p, vi\u00eam \u0111\u01b0\u1eddng m\u1eadt ho\u1eb7c r\u00f2 r\u1ec9 m\u1eadt \u0111\u01b0\u1eddng ni\u1ec7u v\u00e0 d\u1ecb \u1ee9ng v\u1edbi acid m\u1eadt<\/span><\/p>\n

2.2 Th\u00f4ng tin v\u1ec1 thu\u1ed1c Chenix (Chenodiol)<\/span><\/h3>\n

Chenodiol \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng \u0111\u1ec3 h\u00f2a tan m\u1ed9t s\u1ed1 lo\u1ea1i s\u1ecfi m\u1eadt (kh\u00f4ng b\u1ecb v\u00f4i h\u00f3a). Chenodiol c\u00f3 th\u1ec3 \u0111\u01b0\u1ee3c th\u1eed tr\u01b0\u1edbc khi ph\u1eabu thu\u1eadt \u1edf nh\u1eefng b\u1ec7nh nh\u00e2n c\u00f3 nguy c\u01a1 cao b\u1ecb bi\u1ebfn ch\u1ee9ng do ph\u1eabu thu\u1eadt s\u1ecfi m\u1eadt<\/span><\/p>\n

C\u00e1c v\u1ecb tr\u00ed t\u00e1c d\u1ee5ng c\u1ee7a Chenodiol l\u00e0 gan, m\u1eadt v\u00e0 ru\u1ed9t k\u1ebft. \u1ede li\u1ec1u \u0111i\u1ec1u tr\u1ecb, Chenodiol ng\u0103n ch\u1eb7n s\u1ef1 t\u1ed5ng h\u1ee3p \u1edf gan c\u1ee7a c\u1ea3 Cholesterol v\u00e0 Acid cholic, d\u1ea7n d\u1ea7n thay th\u1ebf ch\u1ea5t sau v\u00e0 ch\u1ea5t chuy\u1ec3n h\u00f3a c\u1ee7a Acid deoxycholic, g\u00f3p ph\u1ea7n kh\u1eed b\u00e3o h\u00f2a Cholesterol trong m\u1eadt v\u00e0 d\u1ea7n l\u00e0m tan s\u1ecfi m\u1eadt Cholesterol ph\u00e1t quang.\u00a0<\/span><\/p>\n

\"Chenix
Chenix (Chenodiol)<\/figcaption><\/figure>\n

Chenodiol \u0111\u01b0\u1ee3c h\u1ea5p thu t\u1ed1t trong ru\u1ed9t non v\u00e0 \u0111\u01b0\u1ee3c gan h\u1ea5p thu, t\u1ea1i \u0111\u00e2y thu\u1ed1c \u0111\u01b0\u1ee3c chuy\u1ec3n \u0111\u1ed5i th\u00e0nh d\u1ea1ng li\u00ean h\u1ee3p taurine v\u00e0 glycine \u0111\u01b0\u1ee3c ti\u1ebft v\u00e0 m\u1eadt. \u1ede tr\u1ea1ng th\u00e1i \u1ed5n \u0111\u1ecbnh, m\u1ed9t l\u01b0\u1ee3ng Chenodiol \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng h\u00e0ng ng\u00e0y \u0111\u01b0\u1ee3c vi khu\u1ea9n chuy\u1ec3n h\u00f3a th\u00e0nh Acid lithocholic. Kho\u1ea3ng 80% Acid lithocholic \u0111\u01b0\u1ee3c b\u00e0i ti\u1ebft qua ph\u00e2n, ph\u1ea7n c\u00f2n l\u1ea1i \u0111\u01b0\u1ee3c h\u1ea5p thu v\u00e0 chuy\u1ec3n h\u00f3a \u1edf gan th\u00e0nh d\u1ea1ng li\u00ean h\u1ee3p Sulfolithocholyl k\u00e9m h\u1ea5p thu.\u00a0<\/span><\/p>\n

B\u00ean c\u1ea1nh t\u00e1c d\u1ee5ng hi\u1ec7u qu\u1ea3 trong \u0111i\u1ec1u tr\u1ecb, thu\u1ed1c g\u00e2y ra m\u1ed9t s\u1ed1 t\u00e1c d\u1ee5ng kh\u00f4ng mong mu\u1ed1n. C\u00e1c t\u00e1c d\u1ee5ng ph\u1ee5 r\u00f5 r\u00e0ng v\u00e0 ph\u1ed5 bi\u1ebfn: \u0111au ng\u1ef1c, \u1edbn l\u1ea1nh, ho, s\u1ed1t, h\u1ee5t h\u01a1i, \u0111au h\u1ecdng, lo\u00e9t, xu\u1ea5t huy\u1ebft ho\u1eb7c b\u1ea7m t\u00edm b\u1ea5t th\u01b0\u1eddng, m\u1ec7t m\u1ecfi ho\u1eb7c suy nh\u01b0\u1ee3c, ti\u00eau ch\u1ea3y. M\u1ed9t s\u1ed1 t\u00e1c d\u1ee5ng ph\u1ee5 \u00edt ph\u1ed5 bi\u1ebfn h\u01a1n: \u0111au b\u1ee5ng, \u0111au d\u1ea1 d\u00e0y, \u1ee3 chua, \u0111\u1ea7y h\u01a1i, kh\u00f3 ti\u00eau, m\u1ea5t v\u1ecb gi\u00e1c.<\/span><\/p>\n

Chenodiol ch\u1ed1ng ch\u1ec9 \u0111\u1ecbnh khi c\u00f3 r\u1ed1i lo\u1ea1n ch\u1ee9c n\u0103ng t\u1ebf b\u00e0o gan ho\u1eb7c b\u1ea5t th\u01b0\u1eddng \u1ed1ng m\u1eadt nh\u01b0 \u1ee9 m\u1eadt trong gan, x\u01a1 gan m\u1eadt nguy\u00ean ph\u00e1t ho\u1eb7c x\u01a1 c\u1ee9ng \u0111\u01b0\u1eddng m\u1eadt<\/span><\/p>\n

3.K\u1ebft lu\u1eadn\u00a0<\/strong><\/h2>\n

T\u1ed5ng k\u1ebft l\u1ea1i, s\u1ecfi m\u1eadt l\u00e0 m\u1ed9t c\u0103n b\u1ec7nh kh\u00e1 ph\u1ed5 bi\u1ebfn v\u00e0 c\u00f3 th\u1ec3 g\u00e2y ra nhi\u1ec1u bi\u1ebfn ch\u1ee9ng n\u1ebfu kh\u00f4ng \u0111\u01b0\u1ee3c \u0111i\u1ec1u tr\u1ecb k\u1ecbp th\u1eddi v\u00e0 hi\u1ec7u qu\u1ea3. May m\u1eafn thay, hi\u1ec7n nay \u0111\u00e3 c\u00f3 nhi\u1ec1u ph\u01b0\u01a1ng ph\u00e1p \u0111i\u1ec1u tr\u1ecb s\u1ecfi m\u1eadt, trong \u0111\u00f3 ph\u01b0\u01a1ng ph\u00e1p d\u00f9ng thu\u1ed1c l\u00e0 m\u1ed9t trong nh\u1eefng ph\u01b0\u01a1ng ph\u00e1p \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng ph\u1ed5 bi\u1ebfn.<\/span><\/p>\n

C\u00e1c lo\u1ea1i thu\u1ed1c nh\u01b0 Ursodiol, Chenodiol c\u00f3 th\u1ec3 gi\u00fap tan s\u1ecfi m\u1eadt v\u00e0 ng\u0103n ng\u1eeba t\u00e1i ph\u00e1t. Ngo\u00e0i ra, c\u00e1c thu\u1ed1c gi\u1ea3m \u0111au v\u00e0 kh\u00e1ng vi\u00eam c\u0169ng \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng \u0111\u1ec3 gi\u1ea3m c\u00e1c tri\u1ec7u ch\u1ee9ng li\u00ean quan \u0111\u1ebfn s\u1ecfi m\u1eadt.<\/span><\/p>\n

Tuy nhi\u00ean, vi\u1ec7c s\u1eed d\u1ee5ng thu\u1ed1c \u0111\u1ec3 \u0111i\u1ec1u tr\u1ecb s\u1ecfi m\u1eadt c\u1ea7n \u0111\u01b0\u1ee3c th\u1ef1c hi\u1ec7n d\u01b0\u1edbi s\u1ef1 gi\u00e1m s\u00e1t c\u1ee7a b\u00e1c s\u0129 v\u00e0 theo ch\u1ec9 \u0111\u1ecbnh c\u1ee5 th\u1ec3. N\u1ebfu kh\u00f4ng \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng \u0111\u00fang c\u00e1ch, thu\u1ed1c c\u00f3 th\u1ec3 g\u00e2y ra<\/span><\/p>\n","protected":false},"excerpt":{"rendered":"

S\u1ecfi m\u1eadt l\u00e0 m\u1ed9t c\u0103n b\u1ec7nh kh\u00e1 ph\u1ed5 bi\u1ebfn v\u00e0 c\u00f3 th\u1ec3 g\u00e2y ra nhi\u1ec1u bi\u1ebfn ch\u1ee9ng n\u1ebfu kh\u00f4ng \u0111\u01b0\u1ee3c \u0111i\u1ec1u tr\u1ecb k\u1ecbp th\u1eddi v\u00e0 hi\u1ec7u qu\u1ea3. Hi\u1ec7n nay, \u0111\u00e3 c\u00f3 nhi\u1ec1u ph\u01b0\u01a1ng ph\u00e1p \u0111i\u1ec1u tr\u1ecb s\u1ecfi m\u1eadt, trong \u0111\u00f3 ph\u01b0\u01a1ng ph\u00e1p d\u00f9ng thu\u1ed1c l\u00e0 m\u1ed9t trong nh\u1eefng thu\u1ed1c \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng ph\u1ed5 bi\u1ebfn 1.T\u00ecm […]<\/p>\n","protected":false},"author":54,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[12],"tags":[],"yoast_head":"\nPh\u01b0\u01a1ng ph\u00e1p d\u00f9ng thu\u1ed1c \u0111i\u1ec1u tr\u1ecb s\u1ecfi m\u1eadt - Vinmec<\/title>\n<meta name=\"description\" content=\"Hi\u1ec7n nay, \u0111\u00e3 c\u00f3 nhi\u1ec1u ph\u01b0\u01a1ng ph\u00e1p \u0111i\u1ec1u tr\u1ecb s\u1ecfi m\u1eadt, trong \u0111\u00f3 ph\u01b0\u01a1ng ph\u00e1p d\u00f9ng thu\u1ed1c l\u00e0 m\u1ed9t trong nh\u1eefng thu\u1ed1c \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng hi\u1ec7u qu\u1ea3\" \/>\n<meta name=\"robots\" content=\"noindex, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Ph\u01b0\u01a1ng ph\u00e1p d\u00f9ng thu\u1ed1c \u0111i\u1ec1u tr\u1ecb s\u1ecfi m\u1eadt - 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