{"id":30196,"date":"2023-05-01T23:12:19","date_gmt":"2023-05-01T16:12:19","guid":{"rendered":"http:\/\/noithathoaphat.in\/ctv\/?p=30196"},"modified":"2023-05-01T23:12:58","modified_gmt":"2023-05-01T16:12:58","slug":"phan-loai-va-bao-quan-insulin-bo-y-te","status":"publish","type":"post","link":"http:\/\/noithathoaphat.in\/ctv\/index.php\/2023\/05\/01\/phan-loai-va-bao-quan-insulin-bo-y-te\/","title":{"rendered":"Ph\u00e2n lo\u1ea1i v\u00e0 b\u1ea3o qu\u1ea3n insulin \u2013 B\u1ed9 Y t\u1ebf"},"content":{"rendered":"

C\u00e1c nh\u00f3m thu\u1ed1c \u0111i\u1ec1u tr\u1ecb \u0111\u00e1i th\u00e1o \u0111\u01b0\u1eddng \u0111\u01b0\u1ee3c\u00a0ph\u00e2n lo\u1ea1i<\/em>\u00a0th\u00e0nh hai nh\u00f3m ch\u00ednh: nh\u00f3m insulin<\/em><\/a> v\u00e0 nh\u00f3m h\u1ea1 \u0111\u01b0\u1eddng huy\u1ebft th\u00f4ng qua \u0111\u01b0\u1eddng u\u1ed1ng. R\u1ea5t nhi\u1ec1u d\u1ea1ng insulin<\/em> \u0111i\u1ec1u tr\u1ecb b\u1ec7nh ti\u1ec3u \u0111\u01b0\u1eddng. ph\u00e2n lo\u1ea1i Insulin d\u1ef1a v\u00e0o th\u1eddi gian ch\u00fang b\u1eaft \u0111\u1ea7u t\u00e1c d\u1ee5ng v\u00e0 th\u1eddi gian k\u00e9o d\u00e0i c\u1ee7a t\u00e1c d\u1ee5ng.<\/strong><\/p>\n

\"phan-loai-insulin\"<\/p>\n

1. Ph\u00e2n lo\u1ea1i insulin <\/strong>heo c\u1ea5u tr\u00fac ph\u00e2n t\u1eed:<\/strong><\/h2>\n

– Insulin ng\u01b0\u1edd human insulin\/insulin th\u01b0\u1eddng\/regular insulin: \u0111\u01b0\u1ee3c t\u1ed5ng h\u1ee3p b\u1eb1ng ph\u01b0\u01a1ng ph\u00e1p t\u00e1i t\u1ed5 h\u1ee3p DNA, r\u1ea5t tinh khi\u1ebft, \u00edt g\u00e2y d\u1ecb \u1ee9ng v\u00e0 \u0111\u1ec1 kh\u00e1ng do t\u1ef1 mi\u1ec5n v\u00e0 lo\u1ea1n d\u01b0\u1ee1ng m\u00f4 m\u1ee1 t\u1ea1i ch\u1ed7 ti\u00eam. Thu\u1ed1c c\u0169ng c\u00f3 th\u1ec3 b\u1ea3o qu\u1ea3n \u1edf nhi\u1ec7t \u0111\u1ed9 ph\u00f2ng <30 \u0111\u1ed9 C v\u00e0 c\u00f3 th\u1ec3 mang theo khi \u0111i du l\u1ecbch mi\u1ec5n l\u00e0 tr\u00e1nh nhi\u1ec7t \u0111\u1ed9 r\u1ea5t n\u00f3ng ho\u1eb7c r\u1ea5t l\u1ea1nh. Human insulin hi\u1ec7n c\u00f3 t\u1ea1i Vi\u1ec7t Nam g\u1ed3m insulin th\u01b0\u1eddng (regular insulin) v\u00e0 NPH (Neutral Protamine Hagedorn).<\/p>\n

–\u00a0Insulin analog \u0111\u01b0\u1ee3c t\u1ed5ng h\u1ee3p b\u1eb1ng k\u1ef9 thu\u1eadt t\u00e1i t\u1ed5 h\u1ee3p DNA, nh\u01b0ng c\u00f3 thay \u0111\u1ed5i c\u1ea5u tr\u00fac b\u1eb1ng c\u00e1ch thay th\u1ebf m\u1ed9t v\u00e0i acid amin ho\u1eb7c g\u1eafn th\u00eam chu\u1ed7i polypeptide \u0111\u1ec3 thay \u0111\u1ed5i d\u01b0\u1ee3c t\u00ednh.<\/p>\n

–\u00a0V\u00ed d\u1ee5 v\u1ec1 m\u1ed9t s\u1ed1 insulin analog g\u1ed3m insulin t\u00e1c d\u1ee5ng nhanh nh\u01b0 Aspart, Lispro, Glulisine v\u00e0 lo\u1ea1i t\u00e1c d\u1ee5ng k\u00e9o d\u00e0i nh\u01b0 Detemir, Glargine. Hi\u1ec7n nay, insulin Degludec t\u00e1c d\u1ee5ng d\u00e0i \u0111\u00e3 \u0111\u01b0\u1ee3c c\u1ea5p ph\u00e9p l\u01b0u h\u00e0nh \u1edf Vi\u1ec7t Nam.<\/p>\n

2. Ph\u00e2n lo\u1ea1i insulin <\/strong>theo c\u01a1 ch\u1ebf t\u00e1c d\u1ee5ng:<\/strong><\/h2>\n

2.1 Insulin t\u00e1c d\u1ee5ng nhanh, ng\u1eafn:<\/strong><\/p>\n

–\u00a0Insulin ng\u01b0\u1eddi (regular insulin) l\u00e0 lo\u1ea1i tinh th\u1ec3 insulin zinc h\u00f2a tan, t\u00e1c d\u1ee5ng 30 ph\u00fat sau khi ti\u00eam d\u01b0\u1edbi da, v\u00e0 k\u00e9o d\u00e0i 5- 7 gi\u1edd v\u1edbi li\u1ec1u th\u01b0\u1eddng d\u00f9ng, li\u1ec1u c\u00e0ng cao th\u1eddi gian t\u00e1c d\u1ee5ng c\u00e0ng k\u00e9o d\u00e0i. Thu\u1ed1c c\u00f3 th\u1ec3 truy\u1ec1n t\u0129nh m\u1ea1ch khi \u0111i\u1ec1u tr\u1ecb c\u1ea5p c\u1ee9u h\u00f4n m\u00ea do nhi\u1ec5m ceton acid, t\u0103ng \u00e1p l\u1ef1c th\u1ea9m th\u1ea5u m\u00e1u, khi ph\u1eabu thu\u1eadt.<\/p>\n

–\u00a0Insulin analog t\u00e1c d\u1ee5ng nhanh, ng\u1eafn. Hi\u1ec7n t\u1ea1i c\u00f3 3 lo\u1ea1i insulin analog t\u00e1c d\u1ee5ng nhanh, ng\u1eafn l\u00e0: Aspart, Lispro v\u00e0 Glulisine<\/p>\n

–\u00a0Insulin Aspart: Thay th\u1ebf proline \u1edf v\u1ecb tr\u00ed B28 b\u1eb1ng aspartic acid<\/p>\n

–\u00a0Insulin Lispro: proline \u1edf v\u1ecb tr\u00ed B28 \u0111\u1ed5i ch\u1ed7 v\u1edbi lysine \u1edf v\u1ecb tr\u00ed B29<\/p>\n

–\u00a0Insulin Glulisine: Asparagine \u1edf v\u1ecb tr\u00ed B3 \u0111\u01b0\u1ee3c thay th\u1ebf b\u1eb1ng lysine v\u00e0 lysine \u1edf v\u1ecb tr\u00ed B29 \u0111\u01b0\u1ee3c thay th\u1ebf b\u1eb1ng glutamic acid.<\/p>\n

03 lo\u1ea1i insulin n\u00e0y \u00edt c\u00f3 khuynh h\u01b0\u1edbng t\u1ea1o th\u00e0nh hexamer so v\u1edbi human insulin. Sau khi ti\u00eam d\u01b0\u1edbi da, thu\u1ed1c ph\u00e2n ly nhanh th\u00e0nh monomer v\u00e0 \u0111\u01b0\u1ee3c h\u1ea5p thu, \u0111\u1ea1t \u0111\u1ec9nh t\u00e1c d\u1ee5ng sau 1 gi\u1edd. S\u1ef1 thay \u0111\u1ed5i c\u1ea5u tr\u00fac n\u00e0y kh\u00f4ng \u1ea3nh h\u01b0\u1edfng \u0111\u1ebfn vi\u1ec7c g\u1eafn v\u00e0o th\u1ee5 th\u1ec3 insulin, ngo\u00e0i ra th\u1eddi gian k\u00e9o d\u00e0i t\u00e1c d\u1ee5ng kho\u1ea3ng 4 gi\u1edd, kh\u00f4ng thay \u0111\u1ed5i theo li\u1ec1u d\u00f9ng.<\/p>\n

Do t\u00e1c d\u1ee5ng nhanh c\u1ee7a insulin analog, BN c\u1ea7n l\u01b0u \u00fd c\u00f3 \u0111\u1ee7 l\u01b0\u1ee3ng carbohydrat trong ph\u1ea7n \u0111\u1ea7u c\u1ee7a b\u1eefa \u0103n.<\/p>\n

2.2 \u00a0Insulin t\u00e1c d\u1ee5ng trung b\u00ecnh, trung gian:<\/strong><\/p>\n

NPH (Neutral Protamine Hagedorn ho\u1eb7c Isophane Insulin): thu\u1ed1c c\u00f3 t\u00e1c d\u1ee5ng k\u00e9o d\u00e0i nh\u1edd ph\u1ed1i h\u1ee3p 2 ph\u1ea7n insulin zinc h\u00f2a tan v\u1edbi 1 ph\u1ea7n protamine zinc insulin. Sau khi ti\u00eam d\u01b0\u1edbi da, thu\u1ed1c b\u1eaft d\u1ea7u t\u00e1c d\u1ee5ng sau 2-4 gi\u1edd, \u0111\u1ec9nh t\u00e1c d\u1ee5ng sau 6-7 gi\u1edd v\u00e0 th\u1eddi gian k\u00e9o d\u00e0i kho\u1ea3ng 10-20 gi\u1edd. Th\u01b0\u1eddng c\u1ea7n ti\u00eam 2 l\u1ea7n m\u1ed9t ng\u00e0y \u0111\u1ec3 \u0111\u1ea1t hi\u1ec7u qu\u1ea3 k\u00e9o d\u00e0i.<\/p>\n

2.3 \u00a0Insulin t\u00e1c d\u1ee5ng ch\u1eadm, k\u00e9o d\u00e0i:<\/strong><\/p>\n

Insulin glargine:\u00a0<\/em>Asparagine \u1edf v\u1ecb tr\u00ed A21 \u0111\u01b0\u1ee3c thay th\u1ebf b\u1eb1ng glycine v\u00e0 2 ph\u00e2n t\u1eed asparagine \u0111\u01b0\u1ee3c g\u1eafn th\u00eam v\u00e0o \u0111\u1ea7u t\u1eadn carboxyl c\u1ee7a chu\u1ed7i B. Insulin glargine l\u00e0 dung d\u1ecbch trong, pH acid. Khi ti\u00eam d\u01b0\u1edbi da, thu\u1ed1c s\u1ebd l\u1eafng \u0111\u1ecdng th\u00e0nh c\u00e1c ph\u00e2n t\u1eed nh\u1ecf \u0111\u01b0\u1ee3c ph\u00f3ng th\u00edch t\u1eeb t\u1eeb v\u00e0o m\u00e1u. Thu\u1ed1c k\u00e9o d\u00e0i t\u00e1c d\u1ee5ng 24 gi\u1edd, kh\u00f4ng c\u00f3 \u0111\u1ec9nh cao r\u00f5 r\u1ec7t trong m\u00e1u, khi ti\u00eam 1 l\u1ea7n trong ng\u00e0y s\u1ebd t\u1ea1o m\u1ed9t n\u1ed3ng \u0111\u1ed9 insulin n\u1ec1n. Thu\u1ed1c kh\u00f4ng \u0111\u01b0\u1ee3c tr\u1ed9n l\u1eabn v\u1edbi human insulin.<\/p>\n

Insulin analog detemir<\/em>: threonine \u1edf v\u1ecb tr\u00ed B30 \u0111\u01b0\u1ee3c l\u1ea5y \u0111i v\u00e0 chu\u1ed7i acid b\u00e9o C14 (tetradecanoic acid) \u0111\u01b0\u1ee3c g\u1eafn v\u1edbi lysine \u1edf v\u1ecb tr\u00ed B29 b\u1eb1ng ph\u1ea3n \u1ee9ng acyl h\u00f3a. Thu\u1ed1c k\u00e9o d\u00e0i t\u00e1c d\u1ee5ng 24 gi\u1edd v\u00e0 c\u00f3 th\u1ec3 ti\u00eam d\u01b0\u1edbi da 1-2 l\u1ea7n\/ng\u00e0y \u0111\u1ec3 t\u1ea1o n\u1ed3ng \u0111\u1ed9 insulin n\u1ec1n.\u00a0Thu\u1ed1c s\u1eed d\u1ee5ng \u0111\u01b0\u1ee3c cho ph\u1ee5 n\u1eef c\u00f3 thai.<\/em><\/p>\n

Insulin Degludec:\u00a0<\/em>l\u00e0 insulin analog, threonine \u1edf v\u1ecb tr\u00ed B30 b\u1ecb c\u1eaft b\u1ecf v\u00e0 lysine \u1edf v\u1ecb tr\u00ed B29 \u0111\u01b0\u1ee3c g\u1eafn k\u1ebft v\u1edbi hexdecanoic acid th\u00f4ng qua gamma-L-glutamyl. Trong d\u1ecbch ch\u1ee9a c\u00f3 phenol v\u00e0 k\u1ebdm, insulin Degludec \u1edf d\u1ea1ng dihexamer, nh\u01b0ng khi ti\u00eam d\u01b0\u1edbi da, ch\u00fang k\u1ebft h\u1ee3p th\u00e0nh nh\u1eefng chu\u1ed7i multihexamer r\u1ea5t l\u1edbn, g\u1ed3m h\u00e0ng ng\u00e0n dihexamer. C\u00e1c chu\u1ed7i n\u00e0y ph\u00e2n t\u00e1n r\u1ea5t ch\u1eadm \u1edf m\u00f4 d\u01b0\u1edbi ra v\u00e0 c\u00e1c ph\u00e2n t\u1eed insulin monomer \u0111\u01b0\u1ee3c ph\u00f3ng th\u00edch t\u1eeb t\u1eeb v\u00e0o m\u00e1u v\u1edbi n\u1ed3ng \u0111\u1ed9 \u1ed5n \u0111\u1ecbnh. Th\u1eddi gian b\u00e1n h\u1ee7y c\u1ee7a thu\u1ed1c l\u00e0 25 gi\u1edd. Thu\u1ed1c b\u1eaft \u0111\u1ea7u t\u00e1c d\u1ee5ng 30-90 ph\u00fat sau khi ti\u00eam d\u01b0\u1edbi da v\u00e0 k\u00e9o d\u00e0i t\u00e1c d\u1ee5ng h\u01a1n 42 gi\u1edd. Tr\u1ea1ng th\u00e1i \u1ed5n \u0111\u1ecbnh \u0111\u1ea1t \u0111\u01b0\u1ee3c sau 2 – 3 ng\u00e0y d\u00f9ng thu\u1ed1c v\u00e0 t\u00e1c d\u1ee5ng l\u00e0m gi\u1ea3m glucose c\u1ee7a insulin Degludec \u1edf tr\u1ea1ng th\u00e1i \u1ed5n \u0111\u1ecbnh cho th\u1ea5y s\u1ef1 bi\u1ebfn \u0111\u1ed5i v\u1ec1 h\u1ec7 s\u1ed1 bi\u1ebfn thi\u00ean t\u1eeb ng\u00e0y n\u00e0y qua ng\u00e0y kh\u00e1c th\u1ea5p h\u01a1n 4 l\u1ea7n khi so v\u1edbi insulin glargine U 100. B\u00ean c\u1ea1nh \u0111\u00f3, Degludec cho ph\u00e9p linh ho\u1ea1t v\u1ec1 th\u1eddi gian s\u1eed d\u1ee5ng (kh\u00f4ng b\u1eaft bu\u1ed9c ph\u1ea3i ti\u1ec7m c\u00f9ng th\u1eddi \u0111i\u1ec3m trong ng\u00e0y, ch\u1ec9 c\u1ea7n \u0111\u1ea3m b\u1ea3o t\u1ed1i thi\u1ec3u 08 gi\u1edd gi\u1eefa c\u00e1c l\u1ea7n ti\u00eam).<\/p>\n

2.4 \u00a0Insulin tr\u1ed9n, h\u1ed7n h\u1ee3p<\/strong>:<\/u><\/strong><\/p>\n

Insulin tr\u1ed9n s\u1eb5n g\u1ed3m 2 lo\u1ea1i t\u00e1c d\u1ee5ng nhanh v\u00e0 t\u00e1c d\u1ee5ng d\u00e0i trong m\u1ed9t l\u1ecd ho\u1eb7c m\u1ed9t b\u00fat ti\u00eam. Thu\u1ed1c s\u1ebd c\u00f3 2 \u0111\u1ec9nh t\u00e1c d\u1ee5ng, insulin t\u00e1c d\u1ee5ng nhanh \u0111\u1ec3 chuy\u1ec3n h\u00f3a carbohydrat trong b\u1eefa \u0103n v\u00e0 insulin t\u00e1c d\u1ee5ng d\u00e0i \u0111\u1ec3 t\u1ea1o n\u1ed3ng \u0111\u1ed9 insulin n\u1ec1n gi\u1eefa c\u00e1c b\u1eefa \u0103n. Hi\u1ec7n c\u00f3 c\u00e1c lo\u1ea1i:<\/p>\n

–\u00a070% insulin isophane\/30% insulin h\u00f2a tan<\/p>\n

–\u00a070% insulin aspart k\u1ebft tinh v\u1edbi protamin\/30% insulin aspart h\u00f2a tan<\/p>\n

–\u00a050% Insulin Aspart Protamine\/50% Insulin Aspart h\u00f2a tan<\/p>\n

–\u00a070% insulin Degludec\/30% insulin aspart<\/p>\n

–\u00a075% NPL(neutral protamine lispro)\/25% Insulin Lispro<\/p>\n

–\u00a050% NPL(neutral protamine lispro)\/50% Insulin Lispro<\/p>\n

3. K\u00fd hi\u1ec7u v\u00e0 n\u1ed3ng \u0111\u1ed9 insulin<\/strong><\/h2>\n

M\u1ed9t l\u1ecd insulin c\u00f3 10 mL, v\u1edbi c\u00e1c n\u1ed3ng \u0111\u1ed9 kh\u00e1c nhau. Hi\u1ec7n tr\u00ean th\u1ecb tr\u01b0\u1eddng c\u00f3 2 lo\u1ea1i l\u00e0 40 IU\/mL (U 40-m\u1ed9t l\u1ecd 10 mL c\u00f3 400 \u0111\u01a1n v\u1ecb) v\u00e0 100 IU\/mL (U100- m\u1ed9t l\u1ecd 10 mL c\u00f3 1000 \u0111\u01a1n v\u1ecb). Ch\u00fa \u00fd ph\u1ea3i d\u00f9ng lo\u1ea1i \u1ed1ng ti\u00eam ph\u00f9 h\u1ee3p v\u1edbi n\u1ed3ng \u0111\u1ed9 thu\u1ed1c: insulin lo\u1ea1i U 40 ph\u1ea3i d\u00f9ng \u1ed1ng ti\u00eam insulin 1mL = 40 IU, insulin U100 ph\u1ea3i d\u00f9ng \u1ed1ng ti\u00eam 1mL=100IU.<\/p>\n

Hi\u1ec7n nay, WHO khuy\u1ebfn c\u00e1o n\u00ean chu\u1ea9n h\u00f3a v\u1ec1 h\u00e0m l\u01b0\u1ee3ng 100 IU\/mL \u0111\u1ec3 tr\u00e1nh tr\u01b0\u1eddng h\u1ee3p BN d\u00f9ng nh\u1ea7m \u1ed1ng v\u00e0 kim ti\u00eam d\u1eabn t\u1edbi c\u00e1c ph\u1ea3n \u1ee9ng kh\u00f4ng mong mu\u1ed1n.<\/p>\n

Li\u1ec1u Insulin khi ti\u00eam t\u00ednh theo \u0111\u01a1n v\u1ecb, kh\u00f4ng t\u00ednh theo mL.<\/em><\/p>\n

Hi\u1ec7n nay c\u00f3 lo\u1ea1i b\u00fat ti\u00eam insulin cho human insulin, insulin analog, m\u1ed7i b\u00fat ti\u00eam c\u00f3 300 \u0111\u01a1n v\u1ecb insulin. C\u00f3 lo\u1ea1i 450 \u0111\u01a1n v\u1ecb.<\/p>\n

4. B\u1ea3o qu\u1ea3n<\/strong><\/h2>\n

T\u1ed1t nh\u1ea5t \u0111\u1ec3 \u1edf 2-80<\/sup>C s\u1ebd gi\u1eef \u0111\u01b0\u1ee3c t\u1edbi khi h\u1ebft h\u1ea1n s\u1eed d\u1ee5ng. N\u1ebfu kh\u00f4ng c\u00f3 t\u1ee7 l\u1ea1nh c\u00f3 th\u1ec3 \u0111\u1ec3 \u1edf nhi\u1ec7t ph\u00f2ng <300<\/sup>C cho ph\u00e9p gi\u1eef \u0111\u01b0\u1ee3c 1 th\u00e1ng m\u00e0 kh\u00f4ng gi\u1ea3m t\u00e1c d\u1ee5ng \u0111\u1ed1i v\u1edbi c\u00e1c lo\u1ea1i insulin s\u1ea3n xu\u1ea5t b\u1eb1ng ph\u01b0\u01a1ng ph\u00e1p t\u00e1i t\u1ed5 h\u1ee3p DNA.<\/p>\n

N\u1ebfu insulin \u0111\u1ec3 \u1edf nhi\u1ec7t \u0111\u1ed9 > 300<\/sup>C s\u1ebd gi\u1ea3m t\u00e1c d\u1ee5ng. Lu\u00f4n c\u1ed1 g\u1eafng gi\u1eef insulin trong m\u00f4i tr\u01b0\u1eddng tho\u00e1ng m\u00e1t,\u00a0kh\u00f4ng ti\u1ebfp x\u00fac tr\u1ef1c ti\u1ebfp v\u1edbi \u00e1nh s\u00e1ng m\u1eb7t tr\u1eddi<\/em>. N\u1ebfu d\u00f9ng \u0111\u00e1 l\u1ea1nh c\u1ea7n ch\u00fa \u00fd kh\u00f4ng \u0111\u01b0\u1ee3c l\u00e0m \u0111\u00f4ng l\u1ea1nh insulin.\u00a0Kh\u00f4ng \u0111\u01b0\u1ee3c \u0111\u1ec3 trong ng\u0103n \u0111\u00e1 l\u00e0m h\u1ecfng insulin<\/em>.<\/strong><\/p>\n

5. Sinh kh\u1ea3 d\u1ee5ng c\u1ee7a c\u00e1c lo\u1ea1i insulin<\/strong><\/h2>\n

B\u1ea3ng : Sinh kh\u1ea3 d\u1ee5ng c\u1ee7a c\u00e1c lo\u1ea1i insulin<\/strong><\/p>\n\n\n\n\n\n\n\n\n\n
Lo\u1ea1i insulin<\/strong><\/td>\nKh\u1edfi \u0111\u1ea7u t\u00e1c d\u1ee5ng<\/strong><\/td>\n\u0110\u1ec9nh t\u00e1c d\u1ee5ng<\/strong><\/td>\nTh\u1eddi gian k\u00e9o d\u00e0i t\u00e1c d\u1ee5ng<\/strong><\/td>\n<\/tr>\n
Insulin aspart, lispro, glulisine<\/td>\n5-15 ph\u00fat<\/td>\n30-90 ph\u00fat<\/td>\n3-4 gi\u1edd<\/td>\n<\/tr>\n
Human regular<\/td>\n30-60 ph\u00fat<\/td>\n2 gi\u1edd<\/td>\n6-8 gi\u1edd<\/td>\n<\/tr>\n
Human NPH<\/td>\n2-4 gi\u1edd<\/td>\n6 -7 gi\u1edd<\/td>\n10-20 gi\u1edd<\/td>\n<\/tr>\n
Insulin glargine<\/td>\n30-60 ph\u00fat<\/td>\nKh\u00f4ng \u0111\u1ec9nh<\/td>\n24 gi\u1edd<\/td>\n<\/tr>\n
Insulin detemir<\/td>\n30-60 ph\u00fat<\/td>\nKh\u00f4ng \u0111\u1ec9nh<\/td>\n24 gi\u1edd<\/td>\n<\/tr>\n
Insulin degludec<\/td>\n30-90 ph\u00fat<\/td>\nKh\u00f4ng \u0111\u1ec9nh<\/td>\n42 gi\u1edd<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

Ch\u00fa th\u00edch<\/em>:\u00a0<\/strong>Th\u1eddi gian t\u00e1c d\u1ee5ng c\u1ee7a insulin c\u00f3 th\u1ec3 thay \u0111\u1ed5i t\u00f9y c\u01a1 \u0111\u1ecba BN, v\u1ecb tr\u00ed ti\u00eam ch\u00edch. Th\u1eddi gian tr\u00ean d\u1ef1a v\u00e0o k\u1ebft qu\u1ea3 c\u1ee7a c\u00e1c th\u1eed nghi\u1ec7m l\u00e2m s\u00e0ng.<\/p>\n

T\u00c0I LI\u1ec6U THAM KH\u1ea2O:<\/p>\n

\u00a0S\u1ed1 <\/span>5481\/Q\u0110-BYT “V\u1ec0 VI\u1ec6C BAN H\u00c0NH T\u00c0I LI\u1ec6U CHUY\u00caN M\u00d4N \u201cH\u01af\u1edaNG D\u1eaaN CH\u1ea8N \u0110O\u00c1N V\u00c0 \u0110I\u1ec0U TR\u1eca \u0110\u00c1I TH\u00c1O \u0110\u01af\u1edcNG T\u00cdP 2\u201d, 30\/12\/2020<\/em><\/span><\/p>\n","protected":false},"excerpt":{"rendered":"

C\u00e1c nh\u00f3m thu\u1ed1c \u0111i\u1ec1u tr\u1ecb \u0111\u00e1i th\u00e1o \u0111\u01b0\u1eddng \u0111\u01b0\u1ee3c\u00a0ph\u00e2n lo\u1ea1i\u00a0th\u00e0nh hai nh\u00f3m ch\u00ednh: nh\u00f3m insulin v\u00e0 nh\u00f3m h\u1ea1 \u0111\u01b0\u1eddng huy\u1ebft th\u00f4ng qua \u0111\u01b0\u1eddng u\u1ed1ng. R\u1ea5t nhi\u1ec1u d\u1ea1ng insulin \u0111i\u1ec1u tr\u1ecb b\u1ec7nh ti\u1ec3u \u0111\u01b0\u1eddng. ph\u00e2n lo\u1ea1i Insulin d\u1ef1a v\u00e0o th\u1eddi gian ch\u00fang b\u1eaft \u0111\u1ea7u t\u00e1c d\u1ee5ng v\u00e0 th\u1eddi gian k\u00e9o d\u00e0i c\u1ee7a t\u00e1c d\u1ee5ng. 1. Ph\u00e2n […]<\/p>\n","protected":false},"author":16,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[80,33],"tags":[],"yoast_head":"\nPh\u00e2n lo\u1ea1i v\u00e0 b\u1ea3o qu\u1ea3n insulin \u2013 B\u1ed9 Y t\u1ebf - Vinmec<\/title>\n<meta name=\"description\" content=\"C\u00e1c nh\u00f3m thu\u1ed1c \u0111i\u1ec1u tr\u1ecb \u0111\u00e1i th\u00e1o \u0111\u01b0\u1eddng \u0111\u01b0\u1ee3c\u00a0ph\u00e2n lo\u1ea1i\u00a0th\u00e0nh hai nh\u00f3m ch\u00ednh: nh\u00f3m insulin v\u00e0 nh\u00f3m h\u1ea1 \u0111\u01b0\u1eddng huy\u1ebft th\u00f4ng qua \u0111\u01b0\u1eddng u\u1ed1ng.\" \/>\n<meta name=\"robots\" content=\"noindex, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Ph\u00e2n lo\u1ea1i v\u00e0 b\u1ea3o qu\u1ea3n insulin \u2013 B\u1ed9 Y t\u1ebf - 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