{"id":29986,"date":"2023-05-06T12:01:44","date_gmt":"2023-05-06T05:01:44","guid":{"rendered":"http:\/\/noithathoaphat.in\/ctv\/?p=29986"},"modified":"2023-05-06T12:01:44","modified_gmt":"2023-05-06T05:01:44","slug":"ublituximab-phuong-phap-moi-hua-hen-cho-benh-da-xo-cung","status":"publish","type":"post","link":"http:\/\/noithathoaphat.in\/ctv\/index.php\/2023\/05\/06\/ublituximab-phuong-phap-moi-hua-hen-cho-benh-da-xo-cung\/","title":{"rendered":"Ublituximab – Ph\u01b0\u01a1ng ph\u00e1p m\u1edbi h\u1ee9a h\u1eb9n cho b\u1ec7nh \u0111a x\u01a1 c\u1ee9ng"},"content":{"rendered":"

B\u1ec7nh \u0111a x\u01a1 c\u1ee9ng l\u00e0 m\u1ed9t b\u1ec7nh l\u00fd t\u1ef1 mi\u1ec5n d\u1ecbch \u1ea3nh h\u01b0\u1edfng \u0111\u1ebfn h\u1ec7 th\u1ed1ng th\u1ea7n kinh trung \u01b0\u01a1ng, g\u00e2y ra c\u00e1c tri\u1ec7u ch\u1ee9ng nh\u01b0 gi\u1ea3m kh\u1ea3 n\u0103ng di chuy\u1ec3n, m\u1ea5t c\u00e2n b\u1eb1ng v\u00e0 kh\u00f3 kh\u0103n trong ho\u1ea1t \u0111\u1ed9ng h\u00e0ng ng\u00e0y. Hi\u1ec7n t\u1ea1i, Ublituximab – m\u1ed9t lo\u1ea1i kh\u00e1ng th\u1ec3 \u0111\u01b0\u1ee3c thi\u1ebft k\u1ebf \u0111\u1ec3 li\u00ean k\u1ebft v\u1edbi m\u1ed9t epitope tr\u00ean CD20 – \u0111\u00e3 \u0111\u01b0\u1ee3c nghi\u00ean c\u1ee9u v\u00e0 cho th\u1ea5y ti\u1ec1m n\u0103ng trong \u0111i\u1ec1u tr\u1ecb b\u1ec7nh \u0111a x\u01a1 c\u1ee9ng<\/strong><\/p>\n

1.Th\u00f4ng tin chung v\u1ec1 b\u1ec7nh \u0111a x\u01a1 c\u1ee9ng\u00a0<\/strong><\/h2>\n

B\u1ec7nh \u0111a x\u01a1 c\u1ee9ng (MS)<\/a> l\u00e0 t\u00ecnh tr\u1ea1ng \u1ea3nh h\u01b0\u1edfng \u0111\u1ebfn n\u00e3o v\u00e0 t\u1ee7y s\u1ed1ng, g\u00e2y ra m\u1ed9t lo\u1ea1t c\u00e1c tri\u1ec7u ch\u1ee9ng ti\u1ec1m \u1ea9n, bao g\u1ed3m c\u00e1c v\u1ea5n \u0111\u1ec1 v\u1ec1 th\u1ecb l\u1ef1c, c\u1eed \u0111\u1ed9ng c\u00e1nh tay ho\u1eb7c ch\u00e2n, c\u1ea3m gi\u00e1c ho\u1eb7c th\u0103ng b\u1eb1ng. \u0110a x\u01a1 c\u1ee9ng c\u00f3 th\u1ec3 k\u00e9o d\u00e0i su\u1ed1t \u0111\u1eddi, \u0111\u00f4i khi c\u00f3 th\u1ec3 g\u00e2y ra khuy\u1ebft t\u1eadt nghi\u00eam tr\u1ecdng m\u1eb7c d\u00f9 \u0111\u00f4i khi c\u00f3 th\u1ec3 ch\u1ec9 \u1edf m\u1ee9c \u0111\u1ed9 nh\u1eb9. Trong nhi\u1ec1u tr\u01b0\u1eddng h\u1ee3p, c\u00f3 th\u1ec3 \u0111i\u1ec1u tr\u1ecb c\u00e1c tri\u1ec7u ch\u1ee9ng v\u00e0 tu\u1ed5i th\u1ecd trung b\u00ecnh gi\u1ea3m nh\u1eb9 \u0111\u1ed1i v\u1edbi nh\u1eefng ng\u01b0\u1eddi b\u1ecb \u0111a x\u01a1 c\u1ee9ng<\/span><\/p>\n

\"B\u1ec7nh
B\u1ec7nh \u0111a x\u01a1 c\u1ee9ng<\/figcaption><\/figure>\n

1.1 Nguy\u00ean nh\u00e2n\u00a0<\/span><\/h3>\n

B\u1ec7nh \u0111a x\u01a1 c\u1ee9ng l\u00e0 t\u00ecnh tr\u1ea1ng t\u1ef1 mi\u1ec5n, \u0111\u1ed3ng ngh\u0129a h\u1ec7 th\u1ed1ng mi\u1ec5n d\u1ecbch nh\u1ea7m l\u1eabn m\u1ed9t ph\u1ea7n c\u01a1 th\u1ec3 nh\u01b0 ch\u1ea5t l\u1ea1 v\u00e0 t\u1ea5n c\u00f4ng. T\u01b0\u01a1ng t\u1ef1, trong b\u1ec7nh \u0111a x\u01a1 c\u1ee9ng, h\u1ec7 th\u1ed1ng mi\u1ec5n d\u1ecbch t\u1ea5n c\u00f4ng v\u1ecf myelin trong n\u00e3o v\u00e0 t\u1ee7y s\u1ed1ng. Kh\u00f4ng r\u00f5 nguy\u00ean nh\u00e2n khi\u1ebfn h\u1ec7 th\u1ed1ng mi\u1ec5n d\u1ecbch t\u1ea5n c\u00f4ng v\u1ecf myelin nh\u01b0ng c\u00f3 v\u1ebb m\u1ed9t ph\u1ea7n l\u00e0 do di truy\u1ec1n t\u1eeb gia \u0111\u00ecnh v\u00e0 m\u1ed9t ph\u1ea7n l\u00e0 do c\u00e1c y\u1ebfu t\u1ed1 b\u00ean ngo\u00e0i. M\u1ed9t s\u1ed1 y\u1ebfu t\u1ed1 \u0111\u00e3 \u0111\u01b0\u1ee3c \u0111\u1ec1 xu\u1ea5t l\u00e0 nguy\u00ean nh\u00e2n c\u00f3 th\u1ec3 g\u00e2y ra MS nh\u01b0 gen di truy\u1ec1n tr\u1ef1c ti\u1ebfp, thi\u1ebfu vitamin D, h\u00fat thu\u1ed1c, b\u00e9o ph\u00ec \u1edf tu\u1ed5i thi\u1ebfu ni\u00ean, nhi\u1ec5m virus,…<\/span><\/p>\n

1.2 Tri\u1ec7u ch\u1ee9ng\u00a0<\/span><\/h3>\n

B\u1ec7nh \u0111a x\u01a1 c\u1ee9ng (MS) c\u00f3 th\u1ec3 g\u00e2y ra nhi\u1ec1u tri\u1ec7u ch\u1ee9ng v\u00e0 \u1ea3nh h\u01b0\u1edfng \u0111\u1ebfn b\u1ea5t k\u1ef3 c\u01a1 quan n\u00e0o tr\u00ean c\u01a1 th\u1ec3 nh\u01b0ng m\u1ee9c \u1ea3nh h\u01b0\u1edfng \u0111\u1ed1i v\u1edbi m\u1ed7i ng\u01b0\u1eddi kh\u00e1c nhau. C\u00e1c tri\u1ec7u ch\u1ee9ng c\u00f3 th\u1ec3 ti\u1ebfn tri\u1ec3n x\u1ea5u \u0111i theo th\u1eddi gian v\u1edbi m\u1ed9t s\u1ed1 ng\u01b0\u1eddi, trong khi \u0111\u1ed1i v\u1edbi nh\u1eefng ng\u01b0\u1eddi kh\u00e1c tri\u1ec7u ch\u1ee9ng c\u00f3 th\u1ec3 nh\u1eb9 nh\u00e0ng v\u00e0 kh\u00f4ng bi\u1ec3u hi\u1ec7n r\u00f5. M\u1ed9t s\u1ed1 tri\u1ec7u ch\u1ee9ng ph\u1ed5 bi\u1ebfn g\u1ed3m m\u1ec7t m\u1ecfi, v\u1ea5n \u0111\u1ec1 th\u1ecb l\u1ef1c (m\u1ea5t th\u1ecb l\u1ef1c, m\u00f9 m\u00e0u, nh\u00ecn \u0111\u00f4i, chuy\u1ec3n \u0111\u1ed9ng m\u1eaft li\u00ean t\u1ee5c), t\u00ea ng\u1ee9a ran (\u1edf c\u00e1nh tay, ch\u00e2n, th\u00e2n v\u00e0 th\u01b0\u1eddng lan r\u1ed9ng trong v\u00e0i ng\u00e0y), co th\u1eaft c\u01a1 (co th\u1eaft, co c\u1ee9ng), \u0111au (do t\u1ed5n th\u01b0\u01a1ng h\u1ec7 th\u1ea7n kinh), tr\u1ea7m c\u1ea3m v\u00e0 lo \u00e2u, v\u1ea5n \u0111\u1ec1 t\u00ecnh d\u1ee5c (r\u1ed1i lo\u1ea1n c\u01b0\u01a1ng d\u01b0\u01a1ng, gi\u1ea3m c\u1ea3m gi\u00e1c v\u00e0 b\u00f4i tr\u01a1n \u00e2m \u0111\u1ea1o), n\u00f3i v\u00e0 nu\u1ed1t kh\u00f3 kh\u0103n (ch\u1ee9ng kh\u00f3 nu\u1ed1t, ch\u1ee9ng kh\u00f3 \u0111\u1ecdc), v\u1ea5n \u0111\u1ec1 v\u1ec1 b\u00e0ng quang (ti\u1ec3u ti\u1ec7n kh\u00f4ng t\u1ef1 ch\u1ee7, nhi\u1ec5m tr\u00f9ng \u0111\u01b0\u1eddng ni\u1ec7u t\u00e1i ph\u00e1t), v\u1ea5n \u0111\u1ec1 v\u1ec1 ru\u1ed9t (t\u00e1o b\u00f3n, \u0111\u1ea1i ti\u1ec7n kh\u00f4ng t\u1ef1 ch\u1ee7, k\u00edch \u1ee9ng th\u00e0nh ru\u1ed9t). H\u1ea7u h\u1ebft nh\u1eefng ng\u01b0\u1eddi b\u1ecb MS ch\u1ec9 c\u00f3 m\u1ed9t s\u1ed1 tri\u1ec7u ch\u1ee9ng n\u00e0y<\/span><\/p>\n

1.3 Ch\u1ea9n \u0111o\u00e1n\u00a0<\/span><\/h3>\n

Ch\u1ea9n \u0111o\u00e1n MS r\u1ea5t ph\u1ee9c t\u1ea1p v\u00ec kh\u00f4ng c\u00f3 x\u00e9t nghi\u1ec7m c\u00f3 th\u1ec3 ch\u1ea9n \u0111o\u00e1n ch\u00ednh x\u00e1c b\u1ec7nh n\u00e0y. Ch\u1ea9n \u0111o\u00e1n ch\u1ec9 c\u00f3 th\u1ec3 \u0111\u01b0\u1ee3c th\u1ef1c hi\u1ec7n m\u1ed9t c\u00e1ch ch\u1eafc ch\u1eafn khi c\u00f3 c\u00e1c d\u1ea5u hi\u1ec7u t\u1ea5n c\u00f4ng sau khi ch\u1ee5p MRI, x\u00e9t nghi\u1ec7m m\u00e1u, ki\u1ec3m tra th\u1ea7n kinh<\/span><\/p>\n

2.T\u1ed5ng quan v\u1ec1 thu\u1ed1c Ublituximab (Briumvi)<\/strong><\/h2>\n

\u0110\u1ea7u n\u0103m 2023, FDA \u0111\u00e3 ph\u00ea duy\u1ec7t Ublituximab-xiiy \u0111\u1ec3 \u0111i\u1ec1u tr\u1ecb c\u00e1c d\u1ea1ng t\u00e1i ph\u00e1t c\u1ee7a b\u1ec7nh \u0111a x\u01a1 c\u1ee9ng (RMS) v\u00e0 \u0111\u01b0\u1ee3c b\u00e1n d\u01b0\u1edbi t\u00ean Briumvi. Ph\u00ea duy\u1ec7t \u0111\u00e3 \u0111\u01b0\u1ee3c c\u1ea5p d\u1ef1a tr\u00ean d\u1eef li\u1ec7u t\u1eeb c\u00e1c th\u1eed nghi\u1ec7m ULTIMATE I & II giai \u0111o\u1ea1n 3, \u0111\u00e3 ch\u1ee9ng minh t\u00ednh \u01b0u vi\u1ec7t so v\u1edbi Teriflunomide trong vi\u1ec7c gi\u1ea3m \u0111\u00e1ng k\u1ec3 t\u1ef7 l\u1ec7 t\u00e1i ph\u00e1t h\u00e0ng n\u0103m. 2 th\u1eed nghi\u1ec7m l\u00e2m s\u00e0ng ng\u1eabu nhi\u00ean, m\u00f9 \u0111\u00f4i, gi\u1ea3 \u0111\u00f4i, nh\u00f3m song song, c\u00f3 \u0111\u1ed1i ch\u1ee9ng so s\u00e1nh tr\u00ean \u0111\u1ed1i t\u01b0\u1ee3ng b\u1ec7nh nh\u00e2n m\u1eafc RMS trong 96 tu\u1ea7n. B\u1ec7nh nh\u00e2n \u0111\u01b0\u1ee3c ch\u1ecdn ng\u1eabu nhi\u00ean \u0111\u1ec3 nh\u1eadn Ublituximab, \u0111\u01b0\u1ee3c truy\u1ec1n t\u0129nh m\u1ea1ch 150mg trong 4 gi\u1edd, 450mg 2 tu\u1ea7n sau l\u1ea7n truy\u1ec1n \u0111\u1ea7u ti\u00ean trong 1 gi\u1edd v\u00e0 450 mg c\u1ee9 sau 24 tu\u1ea7n d\u00f9ng trong 1 gi\u1edd, v\u1edbi gi\u1ea3 d\u01b0\u1ee3c u\u1ed1ng h\u00e0ng ng\u00e0y ho\u1eb7c Teriflunomide d\u00f9ng \u0111\u01b0\u1eddng u\u1ed1ng v\u1edbi li\u1ec1u 14 mg m\u1ed7i ng\u00e0y v\u1edbi gi\u1ea3 d\u01b0\u1ee3c ti\u00eam t\u0129nh m\u1ea1ch. K\u1ebft qu\u1ea3 l\u00e0 li\u1ec7u ph\u00e1p n\u00e0y l\u00e0m gi\u1ea3m t\u1ec9 l\u1ec7 t\u00e1i ph\u00e1t h\u1eb1ng n\u0103m d\u01b0\u1edbi 0,1\u00a0<\/span><\/p>\n

\"Ublituximab
Ublituximab (Briumvi)<\/figcaption><\/figure>\n

2.1 Nh\u00f3m d\u01b0\u1ee3c l\u00fd v\u00e0 ch\u1ec9 \u0111\u1ecbnh s\u1eed d\u1ee5ng\u00a0<\/span><\/h3>\n

Thu\u1ed1c ti\u00eam Ublituximab-xiiy n\u1eb1m trong nh\u00f3m thu\u1ed1c th\u1ea7n kinh, kh\u00e1ng th\u1ec3 IgG1 \u0111\u01a1n d\u00f2ng ch\u1ed1ng CD20 v\u00e0 \u0111\u01b0\u1ee3c ch\u1ec9 \u0111\u1ecbnh \u1edf b\u1ec7nh nh\u00e2n tr\u01b0\u1edfng th\u00e0nh \u0111\u1ec3 \u0111i\u1ec1u tr\u1ecb c\u00e1c d\u1ea1ng t\u00e1i ph\u00e1t c\u1ee7a b\u1ec7nh \u0111a x\u01a1 c\u1ee9ng (MS), bao g\u1ed3m h\u1ed9i ch\u1ee9ng \u0111\u01a1n \u0111\u1ed9c v\u1ec1 m\u1eb7t l\u00e2m s\u00e0ng, b\u1ec7nh thuy\u00ean gi\u1ea3m t\u00e1i ph\u00e1t v\u00e0 b\u1ec7nh ti\u1ebfn tri\u1ec3n th\u1ee9 ph\u00e1t \u0111ang ho\u1ea1t \u0111\u1ed9ng<\/span><\/p>\n

2.2 C\u01a1 ch\u1ebf ho\u1ea1t \u0111\u1ed9ng<\/span><\/h3>\n

R\u1ed1i lo\u1ea1n \u0111i\u1ec1u h\u00f2a t\u1ebf b\u00e0o B l\u00e0m c\u01a1 s\u1edf cho c\u01a1 ch\u1ebf b\u1ec7nh sinh c\u1ee7a c\u00e1c b\u1ec7nh ung th\u01b0 kh\u00e1c nhau v\u00e0 c\u00e1c t\u00ecnh tr\u1ea1ng t\u1ef1 mi\u1ec5n d\u1ecbch nh\u01b0 b\u1ec7nh \u0111a x\u01a1 c\u1ee9ng, b\u1ec7nh vi\u00eam t\u1ee7y th\u1ea7n kinh th\u1ecb gi\u00e1c v\u00e0 b\u1ec7nh li\u00ean quan \u0111\u1ebfn myelin oligodendrocyte glycoprotein IgG. CD20 l\u00e0 m\u1ed9t kh\u00e1ng nguy\u00ean \u0111\u01b0\u1ee3c t\u00ecm th\u1ea5y tr\u00ean c\u00e1c t\u1ebf b\u00e0o ti\u1ec1n B, t\u1ebf b\u00e0o B ch\u01b0a tr\u01b0\u1edfng th\u00e0nh\/tr\u01b0\u1edfng th\u00e0nh, t\u1ebf b\u00e0o B tr\u00ed nh\u1edb v\u00e0 qu\u1ea7n th\u1ec3 ph\u1ee5 c\u1ee7a c\u00e1c t\u1ebf b\u00e0o T d\u01b0\u01a1ng t\u00ednh v\u1edbi CD3. Do \u0111\u00f3, c\u00e1c kh\u00e1ng th\u1ec3 kh\u00e1ng CD20 c\u00f3 th\u1ec3 g\u00e2y ra s\u1ef1 suy gi\u1ea3m t\u1ebf b\u00e0o B th\u00f4ng qua qu\u00e1 tr\u00ecnh ch\u1ebft t\u1ebf b\u00e0o tr\u1ef1c ti\u1ebfp v\u00e0 t\u1ea1o ra c\u00e1c con \u0111\u01b0\u1eddng b\u1ed5 sung th\u00f4ng qua trung gian th\u1ee5 th\u1ec3 Fc-gamma (Fc\u03b3R), t\u1eeb \u0111\u00f3 d\u1eabn \u0111\u1ebfn gi\u1ea3m \u0111\u00e1ng k\u1ec3 ho\u1ea1t \u0111\u1ed9ng t\u1ef1 nhi\u00ean c\u1ee7a h\u1ec7 th\u1ed1ng mi\u1ec5n d\u1ecbch v\u00e0 t\u1ea1o \u0111i\u1ec1u ki\u1ec7n cho s\u1ef1 ph\u00e1t tri\u1ec3n c\u1ee7a c\u00e1c b\u1ec7nh ung th\u01b0, c\u00e1c t\u00ecnh tr\u1ea1ng t\u1ef1 mi\u1ec5n. Ublituximab l\u00e0 m\u1ed9t lo\u1ea1i kh\u00e1ng th\u1ec3 c\u00f3 kh\u1ea3 n\u0103ng li\u00ean k\u1ebft v\u1edbi m\u1ed9t epitope tr\u00ean CD20 kh\u00e1c bi\u1ec7t so v\u1edbi c\u00e1c lo\u1ea1i kh\u00e1ng th\u1ec3 kh\u00e1c nh\u01b0 Rituximab, Ofatumumab, Obinutuzumab v\u00e0 Ocrelizumab. T\u1ebf b\u00e0o B \u0111\u01b0\u1ee3c cho l\u00e0 \u0111\u00f3ng vai tr\u00f2 quan tr\u1ecdng trong b\u1ec7nh \u0111a x\u01a1 c\u1ee9ng, v\u00e0 vi\u1ec7c s\u1eed d\u1ee5ng Ublituximab nh\u1eb1m gi\u1ea3m s\u1ed1 l\u01b0\u1ee3ng t\u1ebf b\u00e0o B c\u00f3 th\u1ec3 gi\u00fap \u0111i\u1ec1u ch\u1ec9nh qu\u00e1 tr\u00ecnh mi\u1ec5n d\u1ecbch v\u00e0 gi\u1ea3m c\u00e1c tri\u1ec7u ch\u1ee9ng c\u1ee7a b\u1ec7nh<\/span><\/p>\n

2.3 D\u01b0\u1ee3c \u0111\u1ed9ng h\u1ecdc\u00a0<\/span><\/h3>\n

H\u1ea5p thu: Sau khi s\u1eed d\u1ee5ng Ublituximab theo li\u1ec1u khuy\u1ebfn c\u00e1o \u0111\u00e3 \u0111\u01b0\u1ee3c ph\u00ea duy\u1ec7t, AUC \u1ed5n \u0111\u1ecbnh 3000mcg\/mL v\u00e0 Cmax trung b\u00ecnh l\u00e0 139mcg\/mL<\/span><\/p>\n

Ph\u00e2n b\u1ed1: Th\u1ec3 t\u00edch ph\u00e2n b\u1ed1 (Vd) l\u00e0 3,18L<\/span><\/p>\n

Chuy\u1ec3n h\u00f3a: Qu\u00e1 tr\u00ecnh chuy\u1ec3n h\u00f3a Ublituximab th\u00f4ng qua s\u1ef1 ph\u00e2n h\u1ee7y th\u00e0nh c\u00e1c peptit v\u00e0 axit amin nh\u1ecf h\u01a1n b\u1edfi c\u00e1c enzym ph\u00e2n gi\u1ea3i protein kh\u00f4ng \u0111\u1eb7c hi\u1ec7u<\/span><\/p>\n

Th\u1ea3i tr\u1eeb: Th\u1eddi gian b\u00e1n th\u1ea3i (T1\/2) l\u00e0 22 ng\u00e0y\u00a0<\/span><\/p>\n

2.4 T\u00e1c d\u1ee5ng ph\u1ee5\u00a0<\/span><\/h3>\n

Ublituximab (Briumvi) c\u00f3 th\u1ec3 g\u00e2y ra t\u00e1c d\u1ee5ng ph\u1ee5 nghi\u00eam tr\u1ecdng bao g\u1ed3m ph\u00e1t ban, kh\u00f3 th\u1edf, s\u01b0ng m\u1eb7t, m\u00f4i, l\u01b0\u1ee1i, s\u1ed1t, \u1edbn l\u1ea1nh, gi\u1ea3m IgG v\u00e0 gi\u1ea3m b\u1ea1ch c\u1ea7u trung t\u00ednh. M\u1ed9t s\u1ed1 t\u00e1c d\u1ee5ng ph\u1ee5 ph\u1ed5 bi\u1ebfn nh\u1ea5t c\u1ee7a Briumvi nh\u01b0 s\u1ed1t, \u1edbn l\u1ea1nh, kh\u00f3 ng\u1ee7, m\u1ec7t m\u1ecfi, nhi\u1ec5m virus Herpes<\/span><\/p>\n

2.5 Ch\u1ed1ng ch\u1ec9 \u0111\u1ecbnh\u00a0<\/span><\/h3>\n

Ublituximab (Briumvi) ch\u1ed1ng ch\u1ec9 \u0111\u1ecbnh \u1edf nh\u1eefng b\u1ec7nh nh\u00e2n: nhi\u1ec5m HBV, ti\u1ec1n s\u1eed ph\u1ea3n \u1ee9ng truy\u1ec1n d\u1ecbch<\/span><\/p>\n

3.K\u1ebft lu\u1eadn<\/strong>\u00a0<\/span><\/h2>\n

Ublituximab l\u00e0 m\u1ed9t gi\u1ea3i ph\u00e1p tuy\u1ec7t v\u1eddi cho nh\u1eefng b\u1ec7nh nh\u00e2n s\u1ed1ng chung v\u1edbi MS v\u00e0 cung c\u1ea5p m\u1ed9t ph\u01b0\u01a1ng ph\u00e1p \u0111i\u1ec1u tr\u1ecb thay th\u1ebf h\u1ea5p d\u1eabn c\u00f3 th\u1ec3 \u0111\u01b0\u1ee3c truy\u1ec1n trong 1 gi\u1edd hai l\u1ea7n m\u1ed9t n\u0103m sau li\u1ec1u kh\u1edfi \u0111\u1ea7u<\/span><\/p>\n

 <\/p>\n","protected":false},"excerpt":{"rendered":"

B\u1ec7nh \u0111a x\u01a1 c\u1ee9ng l\u00e0 m\u1ed9t b\u1ec7nh l\u00fd t\u1ef1 mi\u1ec5n d\u1ecbch \u1ea3nh h\u01b0\u1edfng \u0111\u1ebfn h\u1ec7 th\u1ed1ng th\u1ea7n kinh trung \u01b0\u01a1ng, g\u00e2y ra c\u00e1c tri\u1ec7u ch\u1ee9ng nh\u01b0 gi\u1ea3m kh\u1ea3 n\u0103ng di chuy\u1ec3n, m\u1ea5t c\u00e2n b\u1eb1ng v\u00e0 kh\u00f3 kh\u0103n trong ho\u1ea1t \u0111\u1ed9ng h\u00e0ng ng\u00e0y. Hi\u1ec7n t\u1ea1i, Ublituximab – m\u1ed9t lo\u1ea1i kh\u00e1ng th\u1ec3 \u0111\u01b0\u1ee3c thi\u1ebft k\u1ebf \u0111\u1ec3 li\u00ean […]<\/p>\n","protected":false},"author":54,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[12],"tags":[],"yoast_head":"\nUblituximab - Ph\u01b0\u01a1ng ph\u00e1p m\u1edbi h\u1ee9a h\u1eb9n cho b\u1ec7nh \u0111a x\u01a1 c\u1ee9ng<\/title>\n<meta name=\"description\" content=\"Ublituximab - m\u1ed9t lo\u1ea1i kh\u00e1ng th\u1ec3 \u0111\u01b0\u1ee3c thi\u1ebft k\u1ebf \u0111\u1ec3 li\u00ean k\u1ebft v\u1edbi m\u1ed9t epitope tr\u00ean CD20, do \u0111\u00f3 \u0111\u01b0\u1ee3c FDA ch\u1ea5p thu\u1eadn \u0111i\u1ec1u tr\u1ecb b\u1ec7nh \u0111a x\u01a1 c\u1ee9ng\" \/>\n<meta name=\"robots\" content=\"noindex, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Ublituximab - 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