{"id":29220,"date":"2023-05-07T10:16:07","date_gmt":"2023-05-07T03:16:07","guid":{"rendered":"http:\/\/noithathoaphat.in\/ctv\/?p=29220"},"modified":"2023-05-07T10:16:07","modified_gmt":"2023-05-07T03:16:07","slug":"nexobrid-anacaulase-thuoc-moi-trong-dieu-tri-bong-nang","status":"publish","type":"post","link":"http:\/\/noithathoaphat.in\/ctv\/index.php\/2023\/05\/07\/nexobrid-anacaulase-thuoc-moi-trong-dieu-tri-bong-nang\/","title":{"rendered":"NexoBrid (Anacaulase): thu\u1ed1c m\u1edbi trong \u0111i\u1ec1u tr\u1ecb b\u1ecfng n\u1eb7ng"},"content":{"rendered":"

NexoBrid (hay c\u00f2n g\u1ecdi l\u00e0 Anacaulase) l\u00e0 m\u1ed9t lo\u1ea1i thu\u1ed1c m\u1edbi \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng trong \u0111i\u1ec1u tr\u1ecb b\u1ecfng n\u1eb7ng. Thu\u1ed1c \u0111\u01b0\u1ee3c s\u1ea3n xu\u1ea5t b\u1edfi c\u00f4ng ty MediWound, \u0111\u00e3 \u0111\u01b0\u1ee3c ch\u1ee9ng nh\u1eadn an to\u00e0n v\u00e0 hi\u1ec7u qu\u1ea3 b\u1edfi C\u01a1 quan Qu\u1ea3n l\u00fd Th\u1ef1c ph\u1ea9m v\u00e0 D\u01b0\u1ee3c ph\u1ea9m Hoa K\u1ef3 (FDA). NexoBrid l\u00e0 m\u1ed9t enzyme h\u1ee7y ho\u1ea1i protein g\u00e2y ra t\u1ed5n th\u01b0\u01a1ng cho da b\u1ecb b\u1ecfng, gi\u00fap lo\u1ea1i b\u1ecf c\u00e1c m\u00f4 ch\u1ebft v\u00e0 gi\u1ea3m thi\u1ec3u vi\u1ec7c ph\u1ea3i ph\u1eabu thu\u1eadt c\u1eaft b\u1ecf da. Thu\u1ed1c \u0111\u01b0\u1ee3c \u0111\u00e1nh gi\u00e1 l\u00e0 c\u00f3 ti\u1ec1m n\u0103ng \u0111\u1ec3 c\u1ea3i thi\u1ec7n \u0111i\u1ec1u tr\u1ecb b\u1ecfng n\u1eb7ng v\u00e0 gi\u1ea3m thi\u1ec3u s\u1ef1 \u0111au \u0111\u1edbn cho b\u1ec7nh nh\u00e2n.<\/h3>\n

1.T\u00ecm hi\u1ec3u s\u01a1 l\u01b0\u1ee3c v\u1ec1 b\u1ecfng do nhi\u1ec7t<\/strong><\/h2>\n

B\u1ecfng nhi\u1ec7t<\/a> l\u00e0 v\u1ebft th\u01b0\u01a1ng ngo\u00e0i da do nhi\u1ec7t \u0111\u1ed9 qu\u00e1 cao, \u0111i\u1ec3n h\u00ecnh l\u00e0 do ti\u1ebfp x\u00fac v\u1edbi b\u1ec1 m\u1eb7t ho\u1eb7c ch\u1ea5t l\u1ecfng n\u00f3ng, h\u01a1i n\u01b0\u1edbc v\u00e0 ng\u1ecdn l\u1eeda. H\u1ea7u h\u1ebft c\u00e1c v\u1ebft b\u1ecfng \u0111\u1ec1u nh\u1eb9 v\u00e0 c\u00f3 th\u1ec3 \u0111\u01b0\u1ee3c \u0111i\u1ec1u tr\u1ecb ngo\u1ea1i tr\u00fa ho\u1eb7c t\u1ea1i c\u00e1c b\u1ec7nh vi\u1ec7n \u0111\u1ecba ph\u01b0\u01a1ng. Kho\u1ea3ng 6,5% t\u1ed5ng s\u1ed1 b\u1ec7nh nh\u00e2n b\u1ecb b\u1ecfng \u0111\u01b0\u1ee3c \u0111i\u1ec1u tr\u1ecb t\u1ea1i c\u00e1c trung t\u00e2m chuy\u00ean khoa b\u1ecfng. Quy\u1ebft \u0111\u1ecbnh chuy\u1ec3n v\u00e0 \u0111i\u1ec1u tr\u1ecb t\u1ea1i c\u00e1c trung t\u00e2m chuy\u00ean khoa b\u1ecfng d\u1ef1a tr\u00ean m\u1ee9c \u0111\u1ed9 di\u1ec7n t\u00edch b\u1ec1 m\u1eb7t c\u01a1 th\u1ec3 b\u1ecb b\u1ecfng, \u0111\u1ed9 s\u00e2u c\u1ee7a v\u1ebft b\u1ecfng v\u00e0 c\u00e1c \u0111\u1eb7c \u0111i\u1ec3m c\u1ee7a t\u1eebng b\u1ec7nh nh\u00e2n nh\u01b0 tu\u1ed5i t\u00e1c, c\u00e1c v\u1ebft th\u01b0\u01a1ng kh\u00e1c ho\u1eb7c c\u00e1c v\u1ea5n \u0111\u1ec1 y t\u1ebf kh\u00e1c<\/span><\/p>\n

B\u1ecfng nhi\u1ec7t l\u00e0 lo\u1ea1i b\u1ecfng ph\u1ed5 bi\u1ebfn nh\u1ea5t, chi\u1ebfm kho\u1ea3ng 86% s\u1ed1 b\u1ec7nh nh\u00e2n b\u1ecfng c\u1ea7n nh\u1eadp vi\u1ec7n<\/span><\/p>\n

\"B\u1ecfng
B\u1ecfng nhi\u1ec7t<\/figcaption><\/figure>\n

Nguy\u00ean nh\u00e2n: b\u1ecfng th\u01b0\u1eddng do ch\u1ea5t l\u1ecfng n\u00f3ng, h\u01a1i n\u01b0\u1edbc, ng\u1ecdn l\u1eeda, \u0111\u00e8n flash ho\u1eb7c ch\u1ea5n th\u01b0\u01a1ng do \u0111i\u1ec7n.<\/span><\/p>\n

D\u1ecbch t\u1ec5 h\u1ecdc: Kho\u1ea3ng 450.000 b\u1ec7nh nh\u00e2n \u0111\u01b0\u1ee3c \u0111i\u1ec1u tr\u1ecb b\u1ecfng h\u00e0ng n\u0103m v\u00e0 kho\u1ea3ng 30.000 ng\u01b0\u1eddi c\u1ea7n nh\u1eadp vi\u1ec7n t\u1ea1i c\u00e1c trung t\u00e2m b\u1ecfng. Kho\u1ea3ng 86% c\u00e1c ca b\u1ecfng l\u00e0 b\u1ecfng nhi\u1ec7t trong \u0111\u00f3 43% do l\u1eeda, 34% do b\u1ecfng n\u01b0\u1edbc, 9% do v\u1eadt n\u00f3ng. H\u00e0ng n\u0103m, c\u00f3 kho\u1ea3ng 3400 b\u1ec7nh nh\u00e2n t\u1eed vong do b\u1ecfng ho\u1eb7c c\u00e1c bi\u1ebfn ch\u1ee9ng li\u00ean quan nh\u01b0 h\u00edt kh\u00f3i, ng\u1ed9 \u0111\u1ed9c kh\u00ed CO2, ng\u1ed9 \u0111\u1ed9c HCN,…Kho\u1ea3ng 72% s\u1ed1 ca t\u1eed vong n\u00e0y x\u1ea3y ra do h\u1ecfa ho\u1ea1n \u1edf khu d\u00e2n c\u01b0. Do \u0111\u00f3, b\u1ecfng l\u00e0 nguy\u00ean nh\u00e2n th\u1ee9 4 g\u00e2y t\u1eed vong do ch\u1ea5n th\u01b0\u01a1ng v\u00e0 l\u00e0 nguy\u00ean nh\u00e2n th\u1ee9 hai g\u00e2y t\u1eed vong do tai n\u1ea1n \u1edf tr\u1ebb em trong \u0111\u1ed9 tu\u1ed5i t\u1eeb 1-4 tu\u1ed5i.\u00a0<\/span><\/p>\n

Sinh l\u00fd b\u1ec7nh: Da l\u00e0 c\u01a1 quan l\u1edbn nh\u1ea5t c\u1ee7a c\u01a1 th\u1ec3, chi\u1ebfm kho\u1ea3ng 16% tr\u1ecdng l\u01b0\u1ee3ng c\u1ee7a m\u1ed9t ng\u01b0\u1eddi v\u00e0 c\u00f3 c\u00e1c ch\u1ee9c n\u0103ng ch\u00ednh l\u00e0 b\u1ea3o v\u1ec7, \u0111i\u1ec1u ch\u1ec9nh nhi\u1ec7t \u0111\u1ed9 c\u01a1 th\u1ec3, ng\u0103n ng\u1eeba m\u1ea5t ch\u1ea5t l\u1ecfng,…B\u1ecfng nhi\u1ec7t g\u00e2y c\u1ea3 t\u1ed5n th\u01b0\u01a1ng t\u1ea1i ch\u1ed7 v\u00e0 n\u1ebfu n\u1eb7ng g\u00e2y ph\u1ea3n \u1ee9ng to\u00e0n th\u00e2n (>20% di\u1ec7n t\u00edch b\u1ec1 m\u1eb7t c\u01a1 th\u1ec3). C\u00e1c v\u1ebft th\u01b0\u01a1ng c\u1ee5c b\u1ed9 (t\u1eebng v\u00f9ng nh\u1ecf trong t\u1ed5n th\u01b0\u01a1ng) \u0111\u01b0\u1ee3c ph\u00e2n lo\u1ea1i th\u00e0nh 3 v\u00f9ng t\u1ed5n th\u01b0\u01a1ng kh\u00e1c nhau theo m\u00f4 h\u00ecnh m\u1ee5c ti\u00eau h\u00ecnh tr\u00f2n. V\u00f9ng trong c\u00f9ng l\u00e0 v\u00f9ng \u0111\u00f4ng m\u00e1u ho\u1eb7c ho\u1ea1i t\u1eed, \u0111\u1ea1i di\u1ec7n cho v\u00f9ng t\u1ebf b\u00e0o ch\u1ebft kh\u00f4ng h\u1ed3i ph\u1ee5c. V\u00f9ng xung quanh l\u00e0 v\u00f9ng thi\u1ebfu m\u00e1u c\u1ee5c b\u1ed9 ho\u1eb7c \u1ee9 \u0111\u1ecdng, \u0111\u1ea1i di\u1ec7n cho v\u00f9ng gi\u1ea3m tu\u1ea7n ho\u00e0n v\u00e0 l\u00e0 v\u00f9ng c\u00f3 nguy c\u01a1 ti\u1ebfn tri\u1ec3n th\u00e0nh ho\u1ea1i t\u1eed do gi\u1ea3m t\u01b0\u1edbi m\u00e1u ho\u1eb7c nhi\u1ec5m tr\u00f9ng. V\u00f9ng ngo\u00e0i c\u00f9ng l\u00e0 v\u00f9ng sung huy\u1ebft, \u0111\u1ea1i di\u1ec7n cho m\u1ed9t v\u00f9ng gi\u00e3n m\u1ea1ch c\u00f3 h\u1ed3i ph\u1ee5c. B\u1ecfng l\u00e0 nh\u1eefng v\u1ebft th\u01b0\u01a1ng \u0111\u1ed9ng (t\u1ee9c l\u00e0 t\u1ed5n th\u01b0\u01a1ng ti\u1ebfn tri\u1ec3n) c\u00f3 th\u1ec3 ti\u1ebfn tri\u1ec3n trong v\u00e0i gi\u1edd \u0111\u1ebfn v\u00e0i ng\u00e0y, g\u00e2y kh\u00f3 kh\u0103n cho vi\u1ec7c x\u00e1c \u0111\u1ecbnh ch\u00ednh x\u00e1c c\u00e1c v\u00f9ng kh\u00e1c nhau trong giai \u0111o\u1ea1n \u0111\u1ea7u c\u1ee7a v\u1ebft th\u01b0\u01a1ng. Vi\u1ec7c ph\u00e2n lo\u1ea1i v\u00f9ng t\u1ed5n th\u01b0\u01a1ng nh\u01b0 v\u1eady s\u1ebd gi\u00fap cho qu\u00e1 tr\u00ecnh \u0111i\u1ec1u tr\u1ecb \u0111\u01b0\u1ee3c hi\u1ec7u qu\u1ea3 h\u01a1n v\u00e0 \u0111\u1ea3m b\u1ea3o s\u1ef1 ph\u1ee5c h\u1ed3i t\u1ed1i \u0111a cho v\u00f9ng t\u1ed5n th\u01b0\u01a1ng<\/span><\/p>\n

M\u1ee9c \u0111\u1ed9 b\u1ecfng: N\u1ebfu v\u1ebft th\u01b0\u01a1ng do b\u1ecfng ch\u1ec9 li\u00ean quan \u0111\u1ebfn l\u1edbp bi\u1ec3u b\u00ec, n\u00f3 \u0111\u01b0\u1ee3c ph\u00e2n lo\u1ea1i l\u00e0 b\u1ecfng c\u1ea5p \u0111\u1ed9 1 v\u00e0 kh\u00f4ng g\u00e2y ra s\u1ef1 suy gi\u1ea3m ch\u1ee9c n\u0103ng c\u1ee7a da. N\u1ebfu v\u1ebft th\u01b0\u01a1ng lan v\u00e0o l\u1edbp h\u1ea1 b\u00ec th\u00ec \u0111\u01b0\u1ee3c ph\u00e2n lo\u1ea1i l\u00e0 b\u1ecfng \u0111\u1ed9 2 v\u00e0 c\u00f3 th\u1ec3 l\u00e0m gi\u1ea3m ch\u1ee9c n\u0103ng \u0111i\u1ec1u h\u00f2a nhi\u1ec7t \u0111\u1ed9, ng\u0103n m\u1ea5t n\u01b0\u1edbc c\u1ee7a da. N\u1ebfu v\u1ebft th\u01b0\u01a1ng lan r\u1ed9ng qua c\u1ea3 hai l\u1edbp, \u0111\u00e2y l\u00e0 v\u1ebft b\u1ecfng to\u00e0n b\u1ed9 ho\u1eb7c b\u1ecfng \u0111\u1ed9 3 v\u00e0 c\u00e1c ch\u1ee9c n\u0103ng b\u00ecnh th\u01b0\u1eddng c\u1ee7a da b\u1ecb m\u1ea5t. B\u1ecfng b\u1ec1 m\u1eb7t (c\u1ea5p \u0111\u1ed9 1) \u1ea5m, \u0111au, \u0111\u1ecf, m\u1ec1m, th\u01b0\u1eddng kh\u00f4ng ph\u1ed3ng r\u1ed9p v\u00e0 s\u1ebd t\u00e1i \u0111i t\u00e1i l\u1ea1i nhi\u1ec1u l\u1ea7n (v\u00ed d\u1ee5 nh\u01b0 ch\u00e1y n\u1eafng). B\u1ecfng \u0111\u1ed9 2 c\u00f3 th\u1ec3 kh\u00e1c nhau nh\u01b0ng r\u1ea5t \u0111au, \u0111\u1ecf, ph\u1ed3ng r\u1ed9p, \u1ea9m, m\u1ec1m v\u00e0 s\u1ebd t\u00e1i nh\u1ee3t khi ch\u1ea1m v\u00e0o. B\u1ecfng to\u00e0n b\u1ed9 b\u1ec1 d\u00e0y (ho\u1eb7c \u0111\u1ed9 3) \u00edt \u0111au ho\u1eb7c kh\u00f4ng \u0111au, c\u00f3 th\u1ec3 c\u00f3 m\u00e0u tr\u1eafng, n\u00e2u ho\u1eb7c ch\u00e1y th\u00e0nh than v\u00e0 c\u00f3 c\u1ea3m gi\u00e1c ch\u1eafc da khi ch\u1ea1m v\u00e0o v\u00e0 kh\u00f4ng b\u1ecb t\u00e1i nh\u1ee3t<\/span><\/p>\n

\u0110i\u1ec1u tr\u1ecb v\u00e0 ki\u1ec3m so\u00e1t: \u0110i\u1ec1u tr\u1ecb b\u1ecfng b\u1eaft \u0111\u1ea7u t\u1ea1i ch\u1ed7 b\u1ecb th\u01b0\u01a1ng. B\u01b0\u1edbc \u0111\u1ea7u l\u00e0 lo\u1ea1i b\u1ecf v\u1eadt \u0111ang ch\u00e1y v\u00e0 n\u00f3ng khi ti\u1ebfp x\u00fac v\u1edbi da. Nh\u1eefng v\u00f9ng b\u1ecfng nh\u1ecf c\u00f3 th\u1ec3 \u0111\u01b0\u1ee3c l\u00e0m m\u00e1t b\u1eb1ng n\u01b0\u1edbc m\u00e1t ho\u1eb7c dung d\u1ecbch mu\u1ed1i. N\u1ebfu b\u1ec7nh nh\u00e2n b\u1ecb b\u1ecfng n\u1eb7ng, th\u1eadn tr\u1ecdng khi l\u00e0m m\u00e1t qu\u00e1 m\u1ee9c v\u00ec d\u1ec5 d\u1eabn \u0111\u1ebfn h\u1ea1 th\u00e2n nhi\u1ec7t. B\u1ecfng \u0111\u1ed9 2 \u0111\u01b0\u1ee3c \u0111i\u1ec1u tr\u1ecb b\u1eb1ng c\u00e1ch l\u00e0m s\u1ea1ch, b\u00f4i thu\u1ed1c m\u1ee1 kh\u00e1ng sinh ho\u1eb7c b\u0103ng b\u00f3, thu\u1ed1c gi\u1ea3m \u0111au v\u00e0 t\u0103ng c\u01b0\u1eddng ph\u00f2ng ng\u1eeba u\u1ed1n v\u00e1n n\u1ebfu c\u1ea7n. B\u1ec7nh nh\u00e2n b\u1ecb b\u1ecfng n\u1eb7ng s\u1ebd c\u1ea7n h\u1ed3i s\u1ee9c b\u1eb1ng Oxy, theo d\u00f5i tim, \u0111\u1eb7t \u1ed1ng th\u00f4ng m\u0169i, \u1ed1ng th\u00f4ng Foley, thu\u1ed1c gi\u1ea3m \u0111au IV, thu\u1ed1c t\u0103ng c\u01b0\u1eddng ph\u00f2ng ng\u1eeba u\u1ed1n v\u00e1n v\u00e0 chuy\u1ec3n \u0111\u1ebfn trung t\u00e2m b\u1ecfng. N\u1ebfu b\u1ec7nh nh\u00e2n \u0111ang chuy\u1ec3n \u0111\u1ebfn trung t\u00e2m b\u1ecfng, ch\u1ec9 c\u1ea7n l\u00e0m s\u1ea1ch v\u00e0 che v\u1ebft b\u1ecfng m\u00e0 kh\u00f4ng c\u1ea7n b\u00f4i kem ho\u1eb7c thu\u1ed1c m\u1ee1. M\u1ed9t ph\u01b0\u01a1ng ph\u00e1p \u0111i\u1ec1u tr\u1ecb v\u1ebft b\u1ecfng \u0111\u1ed9 2 l\u00e0 ph\u1ee7 l\u00ean v\u1ebft b\u1ecfng b\u1eb1ng thu\u1ed1c m\u1ee1 kh\u00e1ng sinh t\u1ea1i ch\u1ed7, ph\u01b0\u01a1ng ph\u00e1p kh\u00e1c \u0111\u1ec3 x\u1eed l\u00fd v\u1ebft th\u01b0\u01a1ng do b\u1ecfng l\u00e0 \u0111\u1eafp b\u0103ng chuy\u00ean d\u1ee5ng l\u00ean v\u1ebft b\u1ecfng v\u00e0 \u0111\u1ec3 y\u00ean trong kho\u1ea3ng m\u1ed9t tu\u1ea7n.\u00a0<\/span><\/p>\n

2.T\u1ed5ng quan v\u1ec1 thu\u1ed1c Nexobrid (Anacaulase)<\/strong><\/h2>\n

C\u01a1 quan Qu\u1ea3n l\u00fd Th\u1ef1c ph\u1ea9m v\u00e0 D\u01b0\u1ee3c ph\u1ea9m (FDA) \u0111\u00e3 ph\u00ea duy\u1ec7t Nexobrid (Anacaulase) \u0111\u1ec3 lo\u1ea1i b\u1ecf l\u1edbp da kh\u00f4 v\u00e0 da ch\u1ebft do b\u1ecb b\u1ecfng t\u1eeb c\u1ea5p \u0111\u1ed9 2 tr\u1edf l\u00ean. Vi\u1ec7c ch\u1ea5p thu\u1eadn Nexobrid d\u1ef1a tr\u00ean d\u1eef li\u1ec7u t\u1eeb 2 th\u1eed nghi\u1ec7m l\u00e2m s\u00e0ng: th\u1eed nghi\u1ec7m Detect giai \u0111o\u1ea1n 3 so s\u00e1nh NexoBrid v\u1edbi gi\u1ea3 d\u01b0\u1ee3c \u1edf 175 ng\u01b0\u1eddi tr\u01b0\u1edfng th\u00e0nh b\u1ecb b\u1ecfng c\u1ea5p \u0111\u1ed9 2 ho\u1eb7c c\u1ea5p \u0111\u1ed9 3 l\u00ean \u0111\u1ebfn 30% t\u1ed5ng di\u1ec7n t\u00edch b\u1ec1 m\u1eb7t c\u01a1 th\u1ec3 (BSA). K\u1ebft qu\u1ea3 cho th\u1ea5y t\u1ef7 l\u1ec7 lo\u1ea1i b\u1ecf l\u1edbp da kh\u00f4 ch\u1ebft \u226595% v\u00e0o cu\u1ed1i giai \u0111o\u1ea1n \u0111i\u1ec1u tr\u1ecb t\u1ea1i ch\u1ed7 \u0111\u1ed1i v\u1edbi b\u1ec7nh nh\u00e2n trong nh\u00f3m NexoBrid l\u00e0 93% so v\u1edbi 4% nh\u00f3m gi\u1ea3 d\u01b0\u1ee3c. Nexobrid c\u0169ng \u0111\u01b0\u1ee3c \u0111\u00e1nh gi\u00e1 trong m\u1ed9t nghi\u00ean c\u1ee9u 2 tr\u00ean nh\u1eefng b\u1ec7nh nh\u00e2n b\u1ecb b\u1ecfng nhi\u1ec7t s\u00e2u m\u1ed9t ph\u1ea7n v\u00e0 to\u00e0n b\u1ed9 di\u1ec7n t\u00edch t\u1eeb 5 \u0111\u1ebfn 24% BSA . Trong s\u1ed1 nh\u1eefng b\u1ec7nh nh\u00e2n n\u00e0y, 156 ng\u01b0\u1eddi \u0111\u01b0\u1ee3c ch\u1ec9 \u0111\u1ecbnh ng\u1eabu nhi\u00ean \u0111\u1ec3 nh\u1eadn Nexobrid \u0111\u1ea1t hi\u1ec7u qu\u1ea3 khi ch\u1ec9 22% trong s\u1ed1 b\u1ec7nh nh\u00e2n ph\u1ea3i ph\u1eabu thu\u1eadt lo\u1ea1i b\u1ecf da kh\u00f4 sau khi s\u1eed d\u1ee5ng thu\u1ed1c<\/span><\/p>\n

2.1 Nh\u00f3m d\u01b0\u1ee3c l\u00fd\u00a0<\/span><\/h3>\n

NexoBrid (Anacaulase) l\u00e0 h\u1ed7n h\u1ee3p c\u00e1c enzym ph\u00e2n gi\u1ea3i protein \u0111\u01b0\u1ee3c ch\u1ec9 \u0111\u1ecbnh \u0111\u1ec3 lo\u1ea1i b\u1ecf v\u1ea3y \u1edf ng\u01b0\u1eddi l\u1edbn b\u1ecb b\u1ecfng nhi\u1ec7t \u0111\u1ed9 d\u00e0y m\u1ed9t ph\u1ea7n s\u00e2u v\u00e0\/ho\u1eb7c to\u00e0n b\u1ed9 \u0111\u1ed9 d\u00e0y (\u0111\u1ed9 2 ho\u1eb7c \u0111\u1ed9 3)<\/span><\/p>\n

\"NexoBrid
NexoBrid (Anacaulase)<\/figcaption><\/figure>\n

2.2 C\u01a1 ch\u1ebf ho\u1ea1t \u0111\u1ed9ng\u00a0<\/span><\/h3>\n

H\u1ed7n h\u1ee3p enzyme trong Anacaulase h\u00f2a tan l\u1edbp da kh\u00f4 v\u00e0 l\u1edbp da b\u1ecb ch\u1ebft\u00a0<\/span><\/p>\n

2.3 D\u01b0\u1ee3c \u0111\u1ed9ng h\u1ecdc\u00a0<\/span><\/h3>\n

H\u1ea5p thu: Anacaulase \u0111\u01b0\u1ee3c b\u00f4i t\u1ea1i ch\u1ed7 n\u00ean \u0111\u01b0\u1ee3c h\u1ea5p thu nhanh ch\u00f3ng v\u1edbi Tmax = 4 gi\u1edd. AUC v\u00e0 Cmax t\u01b0\u01a1ng quan v\u1edbi li\u1ec1u d\u00f9ng\u00a0<\/span><\/p>\n

Ph\u00e2n b\u1ed1: Kho\u1ea3ng 50% Anacaulase li\u00ean k\u1ebft v\u1edbi c\u00e1c Antiproteinase (\u03b12-macroglobulin v\u00e0 \u03b11-antichymotrypsin) trong huy\u1ebft t\u01b0\u01a1ng\u00a0<\/span><\/p>\n

Chuy\u1ec3n h\u00f3a: Anacaulase \u0111\u01b0\u1ee3c chuy\u1ec3n h\u00f3a b\u1edfi c\u00e1c Protease tr\u00ean kh\u1eafp c\u01a1 th\u1ec3\u00a0<\/span><\/p>\n

Th\u1ea3i tr\u1eeb: Th\u1eddi gian b\u00e1n th\u1ea3i dao \u0111\u1ed9ng t\u1eeb 12-17 gi\u1edd\u00a0<\/span><\/p>\n

2.4 T\u00e1c d\u1ee5ng ph\u1ee5\u00a0<\/span><\/h3>\n

C\u00e1c t\u00e1c d\u1ee5ng ph\u1ee5 ph\u1ed5 bi\u1ebfn th\u01b0\u1eddng x\u1ea3y ra (>10% tr\u01b0\u1eddng h\u1ee3p): ng\u1ee9a (15%) v\u00e0 s\u1ed1t (12%). C\u00e1c t\u00e1c d\u1ee5ng ph\u1ee5 \u00edt g\u1eb7p h\u01a1n g\u1ed3m: bi\u1ebfn ch\u1ee9ng v\u1ebft th\u01b0\u01a1ng (9%), thi\u1ebfu m\u00e1u (6%), n\u00f4n m\u1eeda (5%), m\u1ea5t ng\u1ee7 (5%), nh\u1ecbp tim nhanh (3%), ph\u00e1t ban (3%),….<\/span><\/p>\n

2.5 Ch\u1ed1ng ch\u1ec9 \u0111\u1ecbnh\u00a0<\/span><\/h3>\n

Ch\u1ed1ng ch\u1ec9 \u0111\u1ecbnh v\u1edbi c\u00e1c \u0111\u1ed1i t\u01b0\u1ee3ng qu\u00e1 m\u1eabn v\u1edbi thu\u1ed1c ho\u1eb7c b\u1ea5t k\u1ef3 th\u00e0nh ph\u1ea7n n\u00e0o c\u1ee7a thu\u1ed1c\u00a0<\/span><\/p>\n

3.C\u1ea3nh b\u00e1o v\u00e0 th\u1eadn tr\u1ecdng khi s\u1eed d\u1ee5ng Nexobrid (Anacaulase) trong \u0111i\u1ec1u tr\u1ecb b\u1ecfng<\/strong><\/h2>\n

3.1 Ph\u1ea3n \u1ee9ng qu\u00e1 m\u1eabn khi \u0111i\u1ec1u tr\u1ecb b\u1eb1ng Nexobrid<\/span><\/h3>\n

C\u00e1c ph\u1ea3n \u1ee9ng qu\u00e1 m\u1eabn nghi\u00eam tr\u1ecdng, bao g\u1ed3m s\u1ed1c ph\u1ea3n v\u1ec7, \u0111\u00e3 \u0111\u01b0\u1ee3c b\u00e1o c\u00e1o khi s\u1eed d\u1ee5ng Nexobrid sau khi \u0111\u01b0a ra th\u1ecb tr\u01b0\u1eddng<\/span><\/p>\n

3.2 Ki\u1ec3m so\u00e1t c\u01a1n \u0111au\u00a0<\/span><\/h3>\n

Lo\u1ea1i b\u1ecf l\u1edbp da kh\u00f4 ch\u1ebft b\u1eb1ng thu\u1ed1c Nexobrid \u0111\u1ec3 \u0111i\u1ec1u tr\u1ecb v\u1ebft b\u1ecfng li\u00ean quan \u0111\u1ebfn v\u1ebft th\u01b0\u01a1ng \u0111\u1ec1u g\u00e2y \u0111au \u0111\u1edbn, c\u1ea7n gi\u1ea3m \u0111au v\u00e0\/ho\u1eb7c g\u00e2y m\u00ea \u0111\u1ea7y \u0111\u1ee7. V\u00ec v\u1eady tr\u01b0\u1edbc khi s\u1eed d\u1ee5ng thu\u1ed1c, \u0111\u1ea3m b\u1ea3o \u00e1p d\u1ee5ng \u0111\u1ea7y \u0111\u1ee7 c\u00e1c bi\u1ec7n ph\u00e1p ki\u1ec3m so\u00e1t c\u01a1n \u0111au\u00a0<\/span><\/p>\n

3.3 T\u1ed5n th\u01b0\u01a1ng do ph\u00e2n gi\u1ea3i protein \u0111\u1ed1i v\u1edbi c\u00e1c m\u00f4\u00a0<\/span><\/h3>\n

B\u1ea3o v\u1ec7 b\u1ea5t k\u1ef3 v\u1ebft th\u01b0\u01a1ng h\u1edf n\u00e0o (v\u1ebft r\u00e1ch, da b\u1ecb tr\u1ea7y x\u01b0\u1edbc v\u00e0 v\u1ebft m\u1ed5 r\u1ea1ch t\u1ea7ng sinh m\u00f4n) b\u1eb1ng g\u1ea1c t\u1ea9m thu\u1ed1c m\u1ee1 \u0111\u1ec3 ng\u0103n kh\u1ea3 n\u0103ng ti\u1ebfp x\u00fac v\u1edbi thu\u1ed1c Nexobrid<\/span><\/p>\n

3.4 R\u1ed1i lo\u1ea1n \u0111\u00f4ng m\u00e1u\u00a0<\/span><\/h3>\n

Gi\u1ea3m k\u1ebft t\u1eadp ti\u1ec3u c\u1ea7u v\u00e0 n\u1ed3ng \u0111\u1ed9 fibrinogen trong huy\u1ebft t\u01b0\u01a1ng, t\u0103ng v\u1eeba ph\u1ea3i m\u1ed9t ph\u1ea7n Thromboplastin v\u00e0 th\u1eddi gian Prothrombin \u0111\u00e3 \u0111\u01b0\u1ee3c b\u00e1o c\u00e1o sau khi u\u1ed1ng Nexobrid. Do \u0111\u00f3, tr\u00e1nh s\u1eed d\u1ee5ng thu\u1ed1c \u1edf nh\u1eefng b\u1ec7nh nh\u00e2n b\u1ecb r\u1ed1i lo\u1ea1n \u0111\u00f4ng m\u00e1u kh\u00f4ng ki\u1ec3m so\u00e1t \u0111\u01b0\u1ee3c<\/span><\/p>\n

 <\/p>\n","protected":false},"excerpt":{"rendered":"

NexoBrid (hay c\u00f2n g\u1ecdi l\u00e0 Anacaulase) l\u00e0 m\u1ed9t lo\u1ea1i thu\u1ed1c m\u1edbi \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng trong \u0111i\u1ec1u tr\u1ecb b\u1ecfng n\u1eb7ng. Thu\u1ed1c \u0111\u01b0\u1ee3c s\u1ea3n xu\u1ea5t b\u1edfi c\u00f4ng ty MediWound, \u0111\u00e3 \u0111\u01b0\u1ee3c ch\u1ee9ng nh\u1eadn an to\u00e0n v\u00e0 hi\u1ec7u qu\u1ea3 b\u1edfi C\u01a1 quan Qu\u1ea3n l\u00fd Th\u1ef1c ph\u1ea9m v\u00e0 D\u01b0\u1ee3c ph\u1ea9m Hoa K\u1ef3 (FDA). NexoBrid l\u00e0 m\u1ed9t enzyme h\u1ee7y ho\u1ea1i […]<\/p>\n","protected":false},"author":54,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[12],"tags":[],"yoast_head":"\nNexoBrid (Anacaulase): thu\u1ed1c m\u1edbi trong \u0111i\u1ec1u tr\u1ecb b\u1ecfng n\u1eb7ng<\/title>\n<meta name=\"description\" content=\"NexoBrid (hay c\u00f2n g\u1ecdi l\u00e0 Anacaulase) l\u00e0 m\u1ed9t lo\u1ea1i thu\u1ed1c m\u1edbi \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng trong \u0111i\u1ec1u tr\u1ecb b\u1ecfng n\u1eb7ng v\u00e0 \u0111\u01b0\u1ee3c FDA ch\u1ea5p thu\u1eadn s\u1eed d\u1ee5ng\" \/>\n<meta name=\"robots\" content=\"noindex, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"NexoBrid (Anacaulase): thu\u1ed1c m\u1edbi trong \u0111i\u1ec1u tr\u1ecb 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