{"id":29197,"date":"2023-05-08T08:09:48","date_gmt":"2023-05-08T01:09:48","guid":{"rendered":"http:\/\/noithathoaphat.in\/ctv\/?p=29197"},"modified":"2023-05-08T08:09:48","modified_gmt":"2023-05-08T01:09:48","slug":"tuong-tac-thuoc-giua-diazepam-va-ketoconazole","status":"publish","type":"post","link":"http:\/\/noithathoaphat.in\/ctv\/index.php\/2023\/05\/08\/tuong-tac-thuoc-giua-diazepam-va-ketoconazole\/","title":{"rendered":"T\u01b0\u01a1ng t\u00e1c thu\u1ed1c gi\u1eefa Diazepam v\u00e0 Ketoconazole"},"content":{"rendered":"<p><strong>Diazepam v\u00e0 Ketoconazole l\u00e0 hai lo\u1ea1i thu\u1ed1c \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng ph\u1ed5 bi\u1ebfn trong \u0111i\u1ec1u tr\u1ecb c\u00e1c b\u1ec7nh kh\u00e1c nhau. Diazepam l\u00e0 m\u1ed9t thu\u1ed1c an th\u1ea7n \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng \u0111\u1ec3 \u0111i\u1ec1u tr\u1ecb r\u1ed1i lo\u1ea1n lo \u00e2u v\u00e0 co c\u1ee9ng c\u01a1, trong khi Ketoconazole l\u00e0 m\u1ed9t thu\u1ed1c kh\u00e1ng n\u1ea5m \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng \u0111\u1ec3 \u0111i\u1ec1u tr\u1ecb c\u00e1c b\u1ec7nh n\u1ea5m da, m\u00f3ng tay v\u00e0 nhi\u1ec5m n\u1ea5m h\u00f4 h\u1ea5p. Tuy nhi\u00ean, vi\u1ec7c s\u1eed d\u1ee5ng Diazepam v\u00e0 Ketoconazole c\u00f9ng nhau c\u00f3 th\u1ec3 g\u00e2y ra t\u01b0\u01a1ng t\u00e1c thu\u1ed1c v\u00e0 d\u1eabn \u0111\u1ebfn m\u1ed9t s\u1ed1 t\u00e1c d\u1ee5ng ph\u1ee5. Do \u0111\u00f3, \u0111\u1ec3 tr\u00e1nh t\u01b0\u01a1ng t\u00e1c thu\u1ed1c c\u00f3 h\u1ea1i v\u00e0 \u0111\u1ea3m b\u1ea3o hi\u1ec7u qu\u1ea3 \u0111i\u1ec1u tr\u1ecb t\u1ed1i \u0111a cho b\u1ec7nh nh\u00e2n, b\u1ec7nh nh\u00e2n c\u1ea7n tu\u00e2n th\u1ee7 \u0111\u00fang ch\u1ec9 \u0111\u1ecbnh c\u1ee7a b\u00e1c s\u0129 v\u00e0 th\u00f4ng b\u00e1o v\u1edbi b\u00e1c s\u0129 v\u1ec1 t\u1ea5t c\u1ea3 c\u00e1c lo\u1ea1i thu\u1ed1c \u0111ang s\u1eed d\u1ee5ng tr\u01b0\u1edbc khi s\u1eed d\u1ee5ng Diazepam ho\u1eb7c Ketoconazole. <\/strong><\/p>\n<h2><b>1. Th\u00f4ng tin chung v\u1ec1 thu\u1ed1c Diazepam<\/b><\/h2>\n<h3><b>1.1 C\u01a1 ch\u1ebf t\u00e1c d\u1ee5ng<\/b><\/h3>\n<p><span style=\"font-weight: 400;\">Diazepam l\u00e0 <a href=\"https:\/\/www.vinmec.com\/vi\/thong-tin-duoc\/su-dung-thuoc-toan\/phan-biet-thuoc-huong-va-chat-gay-nghien\/\">thu\u1ed1c h\u01b0\u1edbng th\u1ea7n<\/a> nh\u00f3m Benzodiazepin t\u00e1c d\u1ee5ng k\u00e9o d\u00e0i. <\/span><span style=\"font-weight: 400;\">Diazepam g\u1eafn v\u1edbi c\u00e1c th\u1ee5 th\u1ec3 Benzodiazepin \u01a1\u0309 h\u1ec7 th\u1ea7n kinh trung \u01b0\u01a1ng v\u00e0 c\u00e1c c\u01a1 quan ngo\u1ea1i vi \u0111\u1eb7c bi\u1ec7t. Th\u1ee5 th\u1ec3 Benzodiazepin tr\u00ean h\u1ec7 th\u1ea7n kinh trung \u01b0\u01a1ng c\u00f3 li\u00ean quan ch\u1eb7t ch\u1ebd v\u1edbi th\u1ee5 th\u1ec3 c\u1ee7a Gamma aminobutyric acid (GABA) \u2013 m\u1ed9t ch\u1ea5t d\u1eabn truy\u1ec1n th\u1ea7n kinh ch\u1ee7 y\u1ebfu g\u00e2y \u1ee9c ch\u1ebf \u01a1\u0309 n\u00e3o. Sau khi g\u1eafn v\u1edbi th\u1ee5 th\u1ec3 Benzodiazepin, Diazepam l\u00e0m t\u0103ng kh\u1ea3 n\u0103ng g\u1eafn GABA v\u00e0o th\u1ee5 th\u1ec3 GABA, g\u00e2y t\u0103ng c\u01b0\u1eddng t\u00e1c d\u1ee5ng \u1ee9c ch\u1ebf th\u1ea7n kinh trung \u01b0\u01a1ng.\u00a0<\/span><\/p>\n<figure id=\"attachment_31652\" aria-describedby=\"caption-attachment-31652\" style=\"width: 300px\" class=\"wp-caption aligncenter\"><img decoding=\"async\" loading=\"lazy\" class=\"size-medium wp-image-31652\" src=\"http:\/\/noithathoaphat.in\/ctv\/wp-content\/uploads\/2023\/05\/Diazepam-300x193.png\" alt=\"Diazepam\" width=\"300\" height=\"193\" srcset=\"http:\/\/noithathoaphat.in\/ctv\/wp-content\/uploads\/2023\/05\/Diazepam-300x193.png 300w, http:\/\/noithathoaphat.in\/ctv\/wp-content\/uploads\/2023\/05\/Diazepam.png 596w\" sizes=\"(max-width: 300px) 100vw, 300px\" \/><figcaption id=\"caption-attachment-31652\" class=\"wp-caption-text\">Diazepam<\/figcaption><\/figure>\n<h3><b>1.2 Ch\u1ec9 \u0111\u1ecbnh<\/b><\/h3>\n<p><span style=\"font-weight: 400;\">Diazepam \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng trong nh\u1eefng tr\u1ea1ng th\u00e1i lo \u00e2u, k\u00edch \u0111\u1ed9ng, m\u1ea5t ng\u1ee7.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Trong tr\u01b0\u1eddng h\u1ee3p tr\u1ea7m c\u1ea3m c\u00f3 k\u00e8m tr\u1ea1ng th\u00e1i lo \u00e2u, k\u00edch \u0111\u1ed9ng, m\u1ea5t ng\u1ee7, c\u00f3 th\u1ec3 d\u00f9ng Diazepam c\u00f9ng v\u1edbi c\u00e1c thu\u1ed1c ch\u1ed1ng tr\u1ea7m c\u1ea3m. S\u1ea3ng r\u01b0\u1ee3u c\u1ea5p, c\u00e1c b\u1ec7nh ti\u1ec1n s\u1ea3ng v\u00e0 h\u1ed9i ch\u1ee9ng cai r\u01b0\u1ee3u c\u1ea5p.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Co c\u1ee9ng c\u01a1 do n\u00e3o ho\u1eb7c do th\u1ea7n kinh ngo\u1ea1i vi.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Co gi\u1eadt do s\u1ed1t cao, tr\u1ea1ng th\u00e1i \u0111\u1ed9ng kinh, co gi\u1eadt do ng\u1ed9 \u0111\u1ed9c thu\u1ed1c. Ti\u1ec1n m\u00ea tr\u01b0\u1edbc khi ph\u1eabu thu\u1eadt.<\/span><\/p>\n<h3><b>1.3 T\u00e1c d\u1ee5ng ph\u1ee5<\/b><\/h3>\n<p><span style=\"font-weight: 400;\"><strong><em>Th\u01b0\u1eddng g\u1eb7p:<\/em><\/strong> Bu\u1ed3n ng\u1ee7.<\/span><\/p>\n<p><span style=\"font-weight: 400;\"><strong><em>\u00cdt g\u1eb7p:<\/em><\/strong> Ch\u00f3ng m\u1eb7t, nh\u1ee9c \u0111\u1ea7u. Th\u1ea7n kinh: Kh\u00f3 t\u1eadp trung t\u01b0 t\u01b0\u01a1\u0309ng. C\u01a1 x\u01b0\u01a1ng: M\u1ea5t \u0111i\u1ec1u h\u00f2a, y\u1ebfu c\u01a1.<\/span><\/p>\n<p><span style=\"font-weight: 400;\"><strong><em>Hi\u1ebfm g\u1eb7p:<\/em><\/strong> Ph\u1ea3n \u1ee9ng ngh\u1ecbch th\u01b0\u1eddng nh\u01b0 k\u00edch \u0111\u1ed9ng, hung h\u0103ng, \u1ea3o gi\u00e1c; d\u1ecb \u1ee9ng; v\u00e0ng da, \u0111\u1ed9c t\u00ednh v\u1edbi gan, transaminase t\u0103ng, phosphatase ki\u1ec1m t\u0103ng.<\/span><\/p>\n<h2><b>2. Th\u00f4ng tin chung v\u1ec1 thu\u1ed1c Ketoconazole<\/b><\/h2>\n<h3><b>2.1 C\u01a1 ch\u1ebf t\u00e1c d\u1ee5ng<\/b><\/h3>\n<p><span style=\"font-weight: 400;\">Ketoconazole l\u00e0 m\u1ed9t thu\u1ed1c ch\u1ed1ng n\u1ea5m t\u1ed5ng h\u1ee3p thu\u1ed9c nh\u00f3m Imidazol. Thu\u1ed1c th\u01b0\u1eddng c\u00f3 t\u00e1c d\u1ee5ng k\u00ecm h\u00e3m n\u1ea5m \u1edf n\u1ed3ng \u0111\u1ed9 \u0111\u1ea1t \u0111\u01b0\u1ee3c trong l\u00e2m s\u00e0ng nh\u01b0ng thu\u1ed1c c\u0169ng c\u00f3 th\u1ec3 di\u1ec7t n\u1ea5m \u1edf n\u1ed3ng \u0111\u1ed9 cao sau khi \u1ee7 k\u00e9o d\u00e0i ho\u1eb7c tr\u00ean n\u1ea5m r\u1ea5t nh\u1ea1y c\u1ea3m.<\/span><\/p>\n<figure id=\"attachment_31654\" aria-describedby=\"caption-attachment-31654\" style=\"width: 300px\" class=\"wp-caption aligncenter\"><img decoding=\"async\" loading=\"lazy\" class=\"size-medium wp-image-31654\" src=\"http:\/\/noithathoaphat.in\/ctv\/wp-content\/uploads\/2023\/05\/Ketoconazole-300x180.jpg\" alt=\"Ketoconazole\" width=\"300\" height=\"180\" srcset=\"http:\/\/noithathoaphat.in\/ctv\/wp-content\/uploads\/2023\/05\/Ketoconazole-300x180.jpg 300w, http:\/\/noithathoaphat.in\/ctv\/wp-content\/uploads\/2023\/05\/Ketoconazole-768x461.jpg 768w, http:\/\/noithathoaphat.in\/ctv\/wp-content\/uploads\/2023\/05\/Ketoconazole.jpg 800w\" sizes=\"(max-width: 300px) 100vw, 300px\" \/><figcaption id=\"caption-attachment-31654\" class=\"wp-caption-text\">Ketoconazole<\/figcaption><\/figure>\n<p><span style=\"font-weight: 400;\">C\u0169ng nh\u01b0 c\u00e1c h\u1ee3p ch\u1ea5t azol ch\u1ed1ng n\u1ea5m kh\u00e1c, Ketoconazole \u1ee9c ch\u1ebf ho\u1ea1t t\u00ednh c\u1ee7a cytochrom P450 l\u00e0 h\u1ec7 enzym c\u1ea7n thi\u1ebft cho qu\u00e1 tr\u00ecnh kh\u1eed methyl c\u00e1c 14 alpha-methyl-sterol (th\u00ed d\u1ee5 Lanosterol) th\u00e0nh Ergosterol l\u00e0 sterol ch\u00ednh c\u1ee7a m\u00e0ng t\u1ebf b\u00e0o n\u1ea5m, l\u01b0\u1ee3ng Ergosterol b\u1ecb gi\u1ea3m s\u1ebd l\u00e0m thay \u0111\u1ed5i t\u00ednh th\u1ea5m v\u00e0 ch\u1ee9c n\u0103ng c\u1ee7a m\u00e0ng t\u1ebf b\u00e0o. T\u00e1c d\u1ee5ng di\u1ec7t n\u1ea5m c\u1ee7a Ketoconazole \u1edf n\u1ed3ng \u0111\u1ed9 cao c\u00f3 th\u1ec3 l\u00e0 do t\u00e1c d\u1ee5ng h\u00f3a l\u00fd tr\u1ef1c ti\u1ebfp c\u1ee7a thu\u1ed1c tr\u00ean m\u00e0ng t\u1ebf b\u00e0o n\u1ea5m. In vitro, Ketoconazol n\u1ed3ng \u0111\u1ed9 th\u1ea5p b\u1eb1ng 0,01 microgam\/ml \u0111\u00e3 ng\u0103n Candida albicans h\u00ecnh th\u00e0nh gi\u1ea3 s\u1ee3i n\u1ea5m (pseudohyphae). T\u00e1c d\u1ee5ng n\u00e0y l\u00e0m t\u0103ng kh\u1ea3 n\u0103ng n\u1ea5m d\u1ec5 b\u1ecb th\u1ef1c b\u00e0o khi cho th\u00eam b\u1ea1ch c\u1ea7u \u0111a nh\u00e2n v\u00e0o m\u00f4i tr\u01b0\u1eddng c\u1ea5y v\u00ec b\u1ea1ch c\u1ea7u c\u00f3 kh\u1ea3 n\u0103ng th\u1ef1c b\u00e0o d\u1ec5 h\u01a1n \u1edf pha n\u1ea5m men (yeastphase) so v\u1edbi pha th\u1ec3 s\u1ee3i n\u1ea5m (mycelium). T\u00e1c d\u1ee5ng c\u1ee7a Ketoconazole \u0111\u1ed1i v\u1edbi t\u1ed5ng h\u1ee3p steroid \u1edf ng\u01b0\u1eddi c\u1ea7n nghi\u00ean c\u1ee9u th\u00eam v\u00ec thu\u1ed1c \u1ee9c ch\u1ebf tr\u1ef1c ti\u1ebfp t\u1ed5ng h\u1ee3p c\u00e1c steroid tuy\u1ebfn th\u01b0\u1ee3ng th\u1eadn v\u00e0 Testosterone in vitro v\u00e0 in vivo. Ketoconazol \u1ee9c ch\u1ebf t\u1ed5ng h\u1ee3p steroid ch\u1ee7 y\u1ebfu b\u1eb1ng ng\u0103n c\u1ea3n m\u1ed9t s\u1ed1 h\u1ec7 enzym P450 (nh\u01b0 11 beta-hydroxylase, C-17, 20-lyase, enzym t\u00e1ch chu\u1ed7i b\u00ean c\u1ee7a cholesterol).<\/span><\/p>\n<h3><b>2.2 Ch\u1ec9 \u0111\u1ecbnh<\/b><\/h3>\n<p><b><i>T\u1ea1i ch\u1ed7 <\/i><\/b><span style=\"font-weight: 400;\">(B\u1ec7nh n\u1ea5m): \u0110i\u1ec1u tr\u1ecb n\u1ea5m \u1edf da v\u00e0 ni\u00eam m\u1ea1c (do n\u1ea5m da to\u00e0n th\u00e2n, n\u1ea5m da \u0111\u00f9i, n\u1ea5m loang (tinea versicolor), <a href=\"https:\/\/www.vinmec.com\/vi\/tin-tuc\/thong-tin-suc-khoe\/suc-khoe-tong-quat\/nhiem-nam-candida-o-mieng-co-hong-va-thuc-quan\/\">Candida \u1edf mi\u1ec7ng<\/a>, <a href=\"https:\/\/www.vinmec.com\/vi\/tin-tuc\/thong-tin-suc-khoe\/cac-nguyen-nhan-va-trieu-chung-cua-viem-da-tiet-ba-nhon\/\">vi\u00eam da b\u00e3 nh\u1eddn<\/a>),&#8230;<\/span><\/p>\n<p><b><i>To\u00e0n th\u00e2n:<\/i><\/b><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">B\u1ec7nh n\u1ea5m \u1edf da n\u1eb7ng, dai d\u1eb3ng, kh\u00f4ng \u0111\u00e1p \u1ee9ng v\u1edbi thu\u1ed1c b\u00f4i ngo\u00e0i v\u00e0 c\u00e1c thu\u1ed1c ch\u1ed1ng n\u1ea5m kh\u00e1c (nh\u01b0 Griseofulvin) v\u00e0 vi\u00eam nang l\u00f4ng do Malasseria kh\u00e1ng Fluconazol, Terbinefin ho\u1eb7c Itraconazol ho\u1eb7c \u1edf ng\u01b0\u1eddi b\u1ec7nh kh\u00f4ng dung n\u1ea1p c\u00e1c thu\u1ed1c \u0111\u00f3 khi d\u00f9ng l\u00e2u d\u00e0i. B\u1ec7nh n\u1ea5m candida m\u1ea1n t\u00ednh \u1edf da, ni\u00eam m\u1ea1c, mi\u1ec7ng \u2013 h\u1ea7u kh\u00e1ng Fluconazol ho\u1eb7c Itraconazol ho\u1eb7c kh\u00f4ng dung n\u1ea1p \u0111\u01b0\u1ee3c c\u00e1c thu\u1ed1c \u0111\u00f3.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">B\u1ec7nh Leishmania da ho\u1eb7c ni\u00eam m\u1ea1c \u2013 da v\u00e0 Leishmania n\u1ed9i t\u1ea1ng: Ketoconazole kh\u00f4ng \u0111\u01b0\u1ee3c khuy\u1ebfn c\u00e1o l\u00e0m thu\u1ed1c \u0111\u01b0\u1ee3c ch\u1ecdn \u0111\u1ea7u ti\u00ean. Ung th\u01b0 tuy\u1ebfn ti\u1ec1n li\u1ec7t t\u00e1i ph\u00e1t giai \u0111o\u1ea1n IV; ch\u1ec9 \u0111\u1ecbnh b\u1ed5 sung trong \u0111i\u1ec1u tr\u1ecb c\u1ea5p h\u1ed9i ch\u1ee9ng \u0111\u00f4ng m\u00e1u n\u1ed9i m\u1ea1ch r\u1ea3i r\u00e1c do carcinoma tuy\u1ebfn ti\u1ec1n li\u1ec7t.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">T\u0103ng calci huy\u1ebft \u1edf ng\u01b0\u1eddi l\u1edbn b\u1ecb b\u1ec7nh sarcoid.<\/span><\/li>\n<\/ul>\n<h3><b>2.3 T\u00e1c d\u1ee5ng ph\u1ee5<\/b><\/h3>\n<p><b><i>Th\u01b0\u1eddng g\u1eb7p:<\/i><\/b><span style=\"font-weight: 400;\"> Bu\u1ed3n n\u00f4n, n\u00f4n, \u0111au b\u1ee5ng, t\u00e1o b\u00f3n, \u0111\u1ea7y h\u01a1i, ch\u1ea3y m\u00e1u \u0111\u01b0\u1eddng ti\u00eau h\u00f3a, \u1ec9a ch\u1ea3y. C\u00e1c t\u00e1c d\u1ee5ng n\u00e0y c\u00f3 li\u00ean quan \u0111\u1ebfn li\u1ec1u d\u00f9ng v\u00e0 c\u00f3 th\u1ec3 gi\u1ea3m thi\u1ec3u n\u1ebfu d\u00f9ng thu\u1ed1c c\u00f9ng v\u1edbi th\u1ee9c \u0103n. Ng\u1ee9a, ngo\u1ea1i ban.<\/span><\/p>\n<p><b><i>\u00cdt g\u1eb7p:<\/i><\/b><span style=\"font-weight: 400;\"> T\u0103ng t\u1ea1m th\u1eddi n\u1ed3ng \u0111\u1ed9 transaminase trong huy\u1ebft thanh. \u0110au \u0111\u1ea7u, ch\u00f3ng m\u1eb7t, k\u00edch \u0111\u1ed9ng, ng\u1ee7 g\u00e0 ho\u1eb7c s\u1ed1t. Ph\u00e1t ban, vi\u00eam da, ban xu\u1ea5t huy\u1ebft v\u00e0 m\u00e0y \u0111ay.<\/span><\/p>\n<p><b><i>Hi\u1ebfm g\u1eb7p:<\/i><\/b><span style=\"font-weight: 400;\"> Ph\u1ea3n \u1ee9ng ph\u1ea3n v\u1ec7, ph\u1ea3n \u1ee9ng qu\u00e1 m\u1eabn. R\u1ed1i lo\u1ea1n th\u1ea7n kinh \u2013 t\u00e2m th\u1ea7n (khuynh h\u01b0\u1edbng t\u1ef1 t\u1eed, tr\u1ea7m c\u1ea3m n\u1eb7ng\u2026). V\u00fa to (do t\u00e1c d\u1ee5ng t\u0103ng prolactin b\u1edfi tuy\u1ebfn y\u00ean) v\u00e0 gi\u1ea3m kh\u1ea3 n\u0103ng t\u00ecnh d\u1ee5c \u1edf ng\u01b0\u1eddi b\u1ec7nh nam (do \u1ee9c ch\u1ebf qu\u00e1 tr\u00ecnh t\u1ed5ng h\u1ee3p testosteron). Vi\u00eam gan. Ch\u1ee9ng y\u1ebfu c\u01a1 v\u00e0 \u0111au c\u01a1.<\/span><\/p>\n<h2><b>3. T\u01b0\u01a1ng t\u00e1c thu\u1ed1c gi\u1eefa Diazepam v\u00e0 Ketoconazole<\/b><\/h2>\n<h3><b>3.1 C\u01a1 ch\u1ebf<\/b><\/h3>\n<p><span style=\"font-weight: 400;\">D\u00f9ng \u0111\u1ed3ng th\u1eddi v\u1edbi thu\u1ed1c kh\u00e1ng n\u1ea5m nh\u00f3m azole c\u00f3 th\u1ec3 l\u00e0m t\u0103ng n\u1ed3ng \u0111\u1ed9 Diazepam trong huy\u1ebft t\u01b0\u01a1ng. C\u01a1 ch\u1ebf l\u00e0 \u1ee9c ch\u1ebf chuy\u1ec3n h\u00f3a Diazepam qua CYP3A4.<\/span><\/p>\n<h3><b>3.2 T\u00e1c d\u1ee5ng ph\u1ee5 c\u00f3 th\u1ec3 x\u1ea3y ra khi s\u1eed d\u1ee5ng Diazepam v\u00e0 Ketoconazole c\u00f9ng nhau<\/b><\/h3>\n<p><span style=\"font-weight: 400;\">T\u01b0\u01a1ng t\u00e1c gi\u1eefa hai lo\u1ea1i thu\u1ed1c n\u00e0y c\u00f3 th\u1ec3 l\u00e0m t\u0103ng n\u1ed3ng \u0111\u1ed9 Diazepam trong c\u01a1 th\u1ec3, d\u1eabn \u0111\u1ebfn t\u00e1c d\u1ee5ng ph\u1ee5 nh\u01b0 bu\u1ed3n ng\u1ee7, m\u1ea5t c\u00e2n b\u1eb1ng, kh\u00f3 n\u00f3i, v\u00e0 m\u1ea5t tr\u00ed nh\u1edb.\u00a0<\/span><\/p>\n<h3><b>3.3 Bi\u1ec7n ph\u00e1p x\u1eed l\u00fd t\u01b0\u01a1ng t\u00e1c thu\u1ed1c gi\u1eefa Diazepam v\u00e0 Ketoconazole<\/b><\/h3>\n<p><span style=\"font-weight: 400;\">\u0110\u1ec3 gi\u1ea3m thi\u1ec3u t\u01b0\u01a1ng t\u00e1c thu\u1ed1c gi\u1eefa Diazepam v\u00e0 Ketoconazole, b\u1ec7nh nh\u00e2n c\u1ea7n tu\u00e2n th\u1ee7 c\u00e1c bi\u1ec7n ph\u00e1p sau:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Tr\u00e1nh s\u1eed d\u1ee5ng Diazepam v\u00e0 Ketoconazole c\u00f9ng nhau n\u1ebfu kh\u00f4ng \u0111\u01b0\u1ee3c ch\u1ec9 \u0111\u1ecbnh b\u1edfi b\u00e1c s\u0129.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">C\u00f3 th\u1ec3 \u0111i\u1ec1u ch\u1ec9nh li\u1ec1u l\u01b0\u1ee3ng ho\u1eb7c ch\u1ec9 \u0111\u1ecbnh thay th\u1ebf b\u1eb1ng c\u00e1c lo\u1ea1i thu\u1ed1c kh\u00e1c \u0111\u1ec3 tr\u00e1nh t\u01b0\u01a1ng t\u00e1c thu\u1ed1c c\u00f3 h\u1ea1i.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Theo d\u00f5i c\u00e1c t\u00e1c d\u1ee5ng ph\u1ee5 c\u1ee7a t\u1eebng lo\u1ea1i thu\u1ed1c v\u00e0 b\u00e1o cho b\u00e1c s\u0129 ngay n\u1ebfu c\u00f3 b\u1ea5t k\u1ef3 d\u1ea5u hi\u1ec7u kh\u00f4ng b\u00ecnh th\u01b0\u1eddng n\u00e0o.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Kh\u00f4ng t\u0103ng ho\u1eb7c gi\u1ea3m li\u1ec1u l\u01b0\u1ee3ng thu\u1ed1c m\u1ed9t c\u00e1ch \u0111\u1ed9t ng\u1ed9t m\u00e0 kh\u00f4ng c\u00f3 s\u1ef1 ch\u1ec9 \u0111\u1ecbnh c\u1ee7a b\u00e1c s\u0129.<\/span><\/li>\n<\/ul>\n<h3><strong>3.4 M\u1ee9c \u0111\u1ed9 t\u01b0\u01a1ng t\u00e1c t\u1eeb nhi\u1ec1u ngu\u1ed3n kh\u00e1c nhau<\/strong><\/h3>\n<p><span style=\"font-weight: 400;\">Drug: V\u1eeba ph\u1ea3i<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Medscape: Nghi\u00eam tr\u1ecdng<\/span><\/p>\n<p><span style=\"font-weight: 400;\">WebMD: Nghi\u00eam tr\u1ecdng<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Ngu\u1ed3n: D\u01b0\u1ee3c th\u01b0 Qu\u1ed1c gia Vi\u1ec7t Nam, Drug.com<\/span><\/p>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Diazepam v\u00e0 Ketoconazole l\u00e0 hai lo\u1ea1i thu\u1ed1c \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng ph\u1ed5 bi\u1ebfn trong \u0111i\u1ec1u tr\u1ecb c\u00e1c b\u1ec7nh kh\u00e1c nhau. Diazepam l\u00e0 m\u1ed9t thu\u1ed1c an th\u1ea7n \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng \u0111\u1ec3 \u0111i\u1ec1u tr\u1ecb r\u1ed1i lo\u1ea1n lo \u00e2u v\u00e0 co c\u1ee9ng c\u01a1, trong khi Ketoconazole l\u00e0 m\u1ed9t thu\u1ed1c kh\u00e1ng n\u1ea5m \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng \u0111\u1ec3 \u0111i\u1ec1u tr\u1ecb c\u00e1c b\u1ec7nh [&hellip;]<\/p>\n","protected":false},"author":53,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[12],"tags":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v20.4 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>T\u01b0\u01a1ng t\u00e1c thu\u1ed1c gi\u1eefa Diazepam v\u00e0 Ketoconazole - Vinmec<\/title>\n<meta name=\"description\" content=\"Diazepam v\u00e0 Ketoconazole l\u00e0 hai lo\u1ea1i thu\u1ed1c \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng ph\u1ed5 bi\u1ebfn trong \u0111i\u1ec1u tr\u1ecb c\u00e1c b\u1ec7nh kh\u00e1c nhau. T\u01b0\u01a1ng t\u00e1c thu\u1ed1c\" \/>\n<meta name=\"robots\" content=\"noindex, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"T\u01b0\u01a1ng t\u00e1c thu\u1ed1c gi\u1eefa Diazepam v\u00e0 Ketoconazole - Vinmec\" \/>\n<meta property=\"og:description\" content=\"Diazepam v\u00e0 Ketoconazole l\u00e0 hai lo\u1ea1i thu\u1ed1c \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng ph\u1ed5 bi\u1ebfn trong \u0111i\u1ec1u tr\u1ecb c\u00e1c b\u1ec7nh kh\u00e1c nhau. T\u01b0\u01a1ng t\u00e1c thu\u1ed1c\" \/>\n<meta property=\"og:url\" content=\"http:\/\/noithathoaphat.in\/ctv\/index.php\/2023\/05\/08\/tuong-tac-thuoc-giua-diazepam-va-ketoconazole\/\" \/>\n<meta property=\"og:site_name\" content=\"Vinmec\" \/>\n<meta property=\"article:published_time\" content=\"2023-05-08T01:09:48+00:00\" \/>\n<meta property=\"og:image\" content=\"http:\/\/noithathoaphat.in\/ctv\/wp-content\/uploads\/2023\/05\/Diazepam-300x193.png\" \/>\n<meta name=\"author\" content=\"D\u01b0\u01a1ng Ho\u00e0ng Kim Ki\u1ec1u\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"D\u01b0\u01a1ng Ho\u00e0ng Kim Ki\u1ec1u\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"6 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"http:\/\/noithathoaphat.in\/ctv\/index.php\/2023\/05\/08\/tuong-tac-thuoc-giua-diazepam-va-ketoconazole\/\",\"url\":\"http:\/\/noithathoaphat.in\/ctv\/index.php\/2023\/05\/08\/tuong-tac-thuoc-giua-diazepam-va-ketoconazole\/\",\"name\":\"T\u01b0\u01a1ng t\u00e1c thu\u1ed1c gi\u1eefa Diazepam v\u00e0 Ketoconazole - Vinmec\",\"isPartOf\":{\"@id\":\"https:\/\/noithathoaphat.in\/ctv\/#website\"},\"datePublished\":\"2023-05-08T01:09:48+00:00\",\"dateModified\":\"2023-05-08T01:09:48+00:00\",\"author\":{\"@id\":\"https:\/\/noithathoaphat.in\/ctv\/#\/schema\/person\/0ed39354e8983ddf7029fdd963160052\"},\"description\":\"Diazepam v\u00e0 Ketoconazole l\u00e0 hai lo\u1ea1i thu\u1ed1c \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng ph\u1ed5 bi\u1ebfn trong \u0111i\u1ec1u tr\u1ecb c\u00e1c b\u1ec7nh kh\u00e1c nhau. T\u01b0\u01a1ng t\u00e1c thu\u1ed1c\",\"breadcrumb\":{\"@id\":\"http:\/\/noithathoaphat.in\/ctv\/index.php\/2023\/05\/08\/tuong-tac-thuoc-giua-diazepam-va-ketoconazole\/#breadcrumb\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"http:\/\/noithathoaphat.in\/ctv\/index.php\/2023\/05\/08\/tuong-tac-thuoc-giua-diazepam-va-ketoconazole\/\"]}]},{\"@type\":\"BreadcrumbList\",\"@id\":\"http:\/\/noithathoaphat.in\/ctv\/index.php\/2023\/05\/08\/tuong-tac-thuoc-giua-diazepam-va-ketoconazole\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\/\/noithathoaphat.in\/ctv\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"T\u01b0\u01a1ng t\u00e1c thu\u1ed1c gi\u1eefa Diazepam v\u00e0 Ketoconazole\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\/\/noithathoaphat.in\/ctv\/#website\",\"url\":\"https:\/\/noithathoaphat.in\/ctv\/\",\"name\":\"Vinmec\",\"description\":\"H\u1ec7 th\u1ed1ng Y t\u1ebf Vinmec\",\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\/\/noithathoaphat.in\/ctv\/?s={search_term_string}\"},\"query-input\":\"required name=search_term_string\"}],\"inLanguage\":\"en-US\"},{\"@type\":\"Person\",\"@id\":\"https:\/\/noithathoaphat.in\/ctv\/#\/schema\/person\/0ed39354e8983ddf7029fdd963160052\",\"name\":\"D\u01b0\u01a1ng Ho\u00e0ng Kim Ki\u1ec1u\",\"image\":{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\/\/noithathoaphat.in\/ctv\/#\/schema\/person\/image\/\",\"url\":\"http:\/\/0.gravatar.com\/avatar\/fb5361681d22e08411761f484eed73e7?s=96&d=mm&r=g\",\"contentUrl\":\"http:\/\/0.gravatar.com\/avatar\/fb5361681d22e08411761f484eed73e7?s=96&d=mm&r=g\",\"caption\":\"D\u01b0\u01a1ng Ho\u00e0ng Kim Ki\u1ec1u\"},\"url\":\"http:\/\/noithathoaphat.in\/ctv\/index.php\/author\/duongkieu340gmail-com\/\"}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"T\u01b0\u01a1ng t\u00e1c thu\u1ed1c gi\u1eefa Diazepam v\u00e0 Ketoconazole - Vinmec","description":"Diazepam v\u00e0 Ketoconazole l\u00e0 hai lo\u1ea1i thu\u1ed1c \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng ph\u1ed5 bi\u1ebfn trong \u0111i\u1ec1u tr\u1ecb c\u00e1c b\u1ec7nh kh\u00e1c nhau. T\u01b0\u01a1ng t\u00e1c thu\u1ed1c","robots":{"index":"noindex","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"og_locale":"en_US","og_type":"article","og_title":"T\u01b0\u01a1ng t\u00e1c thu\u1ed1c gi\u1eefa Diazepam v\u00e0 Ketoconazole - Vinmec","og_description":"Diazepam v\u00e0 Ketoconazole l\u00e0 hai lo\u1ea1i thu\u1ed1c \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng ph\u1ed5 bi\u1ebfn trong \u0111i\u1ec1u tr\u1ecb c\u00e1c b\u1ec7nh kh\u00e1c nhau. T\u01b0\u01a1ng t\u00e1c thu\u1ed1c","og_url":"http:\/\/noithathoaphat.in\/ctv\/index.php\/2023\/05\/08\/tuong-tac-thuoc-giua-diazepam-va-ketoconazole\/","og_site_name":"Vinmec","article_published_time":"2023-05-08T01:09:48+00:00","og_image":[{"url":"http:\/\/noithathoaphat.in\/ctv\/wp-content\/uploads\/2023\/05\/Diazepam-300x193.png"}],"author":"D\u01b0\u01a1ng Ho\u00e0ng Kim Ki\u1ec1u","twitter_card":"summary_large_image","twitter_misc":{"Written by":"D\u01b0\u01a1ng Ho\u00e0ng Kim Ki\u1ec1u","Est. reading time":"6 minutes"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"WebPage","@id":"http:\/\/noithathoaphat.in\/ctv\/index.php\/2023\/05\/08\/tuong-tac-thuoc-giua-diazepam-va-ketoconazole\/","url":"http:\/\/noithathoaphat.in\/ctv\/index.php\/2023\/05\/08\/tuong-tac-thuoc-giua-diazepam-va-ketoconazole\/","name":"T\u01b0\u01a1ng t\u00e1c thu\u1ed1c gi\u1eefa Diazepam v\u00e0 Ketoconazole - Vinmec","isPartOf":{"@id":"https:\/\/noithathoaphat.in\/ctv\/#website"},"datePublished":"2023-05-08T01:09:48+00:00","dateModified":"2023-05-08T01:09:48+00:00","author":{"@id":"https:\/\/noithathoaphat.in\/ctv\/#\/schema\/person\/0ed39354e8983ddf7029fdd963160052"},"description":"Diazepam v\u00e0 Ketoconazole l\u00e0 hai lo\u1ea1i thu\u1ed1c \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng ph\u1ed5 bi\u1ebfn trong \u0111i\u1ec1u tr\u1ecb c\u00e1c b\u1ec7nh kh\u00e1c nhau. T\u01b0\u01a1ng t\u00e1c thu\u1ed1c","breadcrumb":{"@id":"http:\/\/noithathoaphat.in\/ctv\/index.php\/2023\/05\/08\/tuong-tac-thuoc-giua-diazepam-va-ketoconazole\/#breadcrumb"},"inLanguage":"en-US","potentialAction":[{"@type":"ReadAction","target":["http:\/\/noithathoaphat.in\/ctv\/index.php\/2023\/05\/08\/tuong-tac-thuoc-giua-diazepam-va-ketoconazole\/"]}]},{"@type":"BreadcrumbList","@id":"http:\/\/noithathoaphat.in\/ctv\/index.php\/2023\/05\/08\/tuong-tac-thuoc-giua-diazepam-va-ketoconazole\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https:\/\/noithathoaphat.in\/ctv\/"},{"@type":"ListItem","position":2,"name":"T\u01b0\u01a1ng t\u00e1c thu\u1ed1c gi\u1eefa Diazepam v\u00e0 Ketoconazole"}]},{"@type":"WebSite","@id":"https:\/\/noithathoaphat.in\/ctv\/#website","url":"https:\/\/noithathoaphat.in\/ctv\/","name":"Vinmec","description":"H\u1ec7 th\u1ed1ng Y t\u1ebf Vinmec","potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/noithathoaphat.in\/ctv\/?s={search_term_string}"},"query-input":"required name=search_term_string"}],"inLanguage":"en-US"},{"@type":"Person","@id":"https:\/\/noithathoaphat.in\/ctv\/#\/schema\/person\/0ed39354e8983ddf7029fdd963160052","name":"D\u01b0\u01a1ng Ho\u00e0ng Kim Ki\u1ec1u","image":{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/noithathoaphat.in\/ctv\/#\/schema\/person\/image\/","url":"http:\/\/0.gravatar.com\/avatar\/fb5361681d22e08411761f484eed73e7?s=96&d=mm&r=g","contentUrl":"http:\/\/0.gravatar.com\/avatar\/fb5361681d22e08411761f484eed73e7?s=96&d=mm&r=g","caption":"D\u01b0\u01a1ng Ho\u00e0ng Kim Ki\u1ec1u"},"url":"http:\/\/noithathoaphat.in\/ctv\/index.php\/author\/duongkieu340gmail-com\/"}]}},"_links":{"self":[{"href":"http:\/\/noithathoaphat.in\/ctv\/index.php\/wp-json\/wp\/v2\/posts\/29197"}],"collection":[{"href":"http:\/\/noithathoaphat.in\/ctv\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"http:\/\/noithathoaphat.in\/ctv\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"http:\/\/noithathoaphat.in\/ctv\/index.php\/wp-json\/wp\/v2\/users\/53"}],"replies":[{"embeddable":true,"href":"http:\/\/noithathoaphat.in\/ctv\/index.php\/wp-json\/wp\/v2\/comments?post=29197"}],"version-history":[{"count":6,"href":"http:\/\/noithathoaphat.in\/ctv\/index.php\/wp-json\/wp\/v2\/posts\/29197\/revisions"}],"predecessor-version":[{"id":32650,"href":"http:\/\/noithathoaphat.in\/ctv\/index.php\/wp-json\/wp\/v2\/posts\/29197\/revisions\/32650"}],"wp:attachment":[{"href":"http:\/\/noithathoaphat.in\/ctv\/index.php\/wp-json\/wp\/v2\/media?parent=29197"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"http:\/\/noithathoaphat.in\/ctv\/index.php\/wp-json\/wp\/v2\/categories?post=29197"},{"taxonomy":"post_tag","embeddable":true,"href":"http:\/\/noithathoaphat.in\/ctv\/index.php\/wp-json\/wp\/v2\/tags?post=29197"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}