{"id":29167,"date":"2023-05-06T15:00:12","date_gmt":"2023-05-06T08:00:12","guid":{"rendered":"http:\/\/noithathoaphat.in\/ctv\/?p=29167"},"modified":"2023-05-06T15:00:12","modified_gmt":"2023-05-06T08:00:12","slug":"tofersen-thuoc-moi-dieu-tri-benh-xo-cung-teo-co-mot-ben","status":"publish","type":"post","link":"http:\/\/noithathoaphat.in\/ctv\/index.php\/2023\/05\/06\/tofersen-thuoc-moi-dieu-tri-benh-xo-cung-teo-co-mot-ben\/","title":{"rendered":"Tofersen thu\u1ed1c m\u1edbi \u0111i\u1ec1u tr\u1ecb b\u1ec7nh x\u01a1 c\u1ee9ng teo c\u01a1 m\u1ed9t b\u00ean"},"content":{"rendered":"

Tofersen l\u00e0 m\u1ed9t lo\u1ea1i thu\u1ed1c m\u1edbi \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng \u0111\u1ec3 \u0111i\u1ec1u tr\u1ecb b\u1ec7nh x\u01a1 c\u1ee9ng teo c\u01a1 m\u1ed9t b\u00ean (SOD1-ALS), m\u1ed9t c\u0103n b\u1ec7nh th\u1ea7n kinh ti\u1ebfn tri\u1ec3n nhanh v\u00e0 g\u00e2y ra kh\u00f3 kh\u0103n trong vi\u1ec7c \u0111i l\u1ea1i, n\u00f3i chuy\u1ec7n v\u00e0 th\u1edf. Thu\u1ed1c \u0111\u01b0\u1ee3c ti\u00eam tr\u1ef1c ti\u1ebfp v\u00e0o d\u1ecbch n\u00e3o t\u1ee7y (CSF), cho ph\u00e9p ph\u00e2n ph\u1ed1i tr\u1ef1c ti\u1ebfp \u0111\u1ebfn c\u00e1c m\u00f4 trong h\u1ec7 th\u1ed1ng th\u1ea7n kinh trung \u01b0\u01a1ng. Tofersen c\u00f3 ti\u1ec1m n\u0103ng \u0111\u1ec3 c\u1ea3i thi\u1ec7n ch\u1ea5t l\u01b0\u1ee3ng cu\u1ed9c s\u1ed1ng c\u1ee7a nh\u1eefng ng\u01b0\u1eddi m\u1eafc b\u1ec7nh SOD1-ALS v\u00e0 l\u00e0 m\u1ed9t b\u01b0\u1edbc ti\u1ebfn l\u1edbn trong nghi\u00ean c\u1ee9u v\u00e0 \u0111i\u1ec1u tr\u1ecb c\u00e1c b\u1ec7nh l\u00fd th\u1ea7n kinh.<\/b><\/p>\n

1. T\u1ed5ng quan v\u1ec1 b\u1ec7nh x\u01a1 c\u1ee9ng teo c\u01a1 m\u1ed9t b\u00ean<\/b><\/h2>\n

X\u01a1 c\u1ee9ng teo c\u01a1 m\u1ed9t b\u00ean (ALS),<\/a> c\u00f2n g\u1ecdi l\u00e0 b\u1ec7nh n\u01a1ron v\u1eadn \u0111\u1ed9ng (MND) hay b\u1ec7nh Lou Gehrig – l\u00e0 m\u1ed9t r\u1ed1i lo\u1ea1n tho\u00e1i h\u00f3a th\u1ea7n kinh ti\u1ebfn tri\u1ec3n nhanh ch\u00f3ng c\u1ee7a t\u1ebf b\u00e0o th\u1ea7n kinh v\u1eadn \u0111\u1ed9ng tr\u00ean v\u00e0 t\u1ebf b\u00e0o th\u1ea7n kinh v\u1eadn \u0111\u1ed9ng d\u01b0\u1edbi. \u0110\u00e2y l\u00e0 lo\u1ea1i b\u1ec7nh th\u1ea7n kinh v\u1eadn \u0111\u1ed9ng ph\u1ed5 bi\u1ebfn nh\u1ea5t \u1edf d\u00e2n s\u1ed1 trung ni\u00ean v\u00e0 cao tu\u1ed5i, v\u00e0 th\u01b0\u1eddng kh\u1edfi ph\u00e1t \u1edf \u0111\u1ed9 tu\u1ed5i t\u1eeb 47-63 tu\u1ed5i. D\u1ea5u hi\u1ec7u l\u00e2m s\u00e0ng c\u1ee7a b\u1ec7nh ALS kh\u1edfi ph\u00e1t\u00a0 ban \u0111\u1ea7u ch\u1ec9 l\u00e0 s\u1ef1 tham gia c\u1ee7a c\u1ea3 r\u1ed1i lo\u1ea1n ch\u1ee9c n\u0103ng t\u1ebf b\u00e0o th\u1ea7n kinh v\u1eadn \u0111\u1ed9ng ph\u00eda tr\u00ean nh\u01b0 y\u1ebfu, co c\u1ee9ng v\u00e0 r\u1ed1i lo\u1ea1n ch\u1ee9c n\u0103ng t\u1ebf b\u00e0o th\u1ea7n kinh v\u1eadn \u0111\u1ed9ng ph\u00eda d\u01b0\u1edbi nh\u01b0 chu\u1ed9t r\u00fat c\u01a1, gi\u1eadt c\u01a1 v\u00e0 teo c\u01a1. M\u1ed9t ph\u1ea7n ba c\u00e1c tr\u01b0\u1eddng h\u1ee3p kh\u1edfi ph\u00e1t \u1edf h\u00e0nh tu\u1ef7 v\u1edbi bi\u1ec3u hi\u1ec7n r\u1ed1i lo\u1ea1n v\u1eadn ng\u00f4n, kh\u00f3 nu\u1ed1t v\u00e0 sau \u0111\u00f3 l\u00e0 c\u00e1c \u0111\u1eb7c \u0111i\u1ec3m chi. Th\u1eddi gian s\u1ed1ng s\u00f3t trung b\u00ecnh c\u1ee7a b\u1ec7nh nh\u00e2n ALS t\u1eeb khi kh\u1edfi ph\u00e1t \u0111\u1ebfn khi t\u1eed vong l\u00e0 t\u1eeb 3 \u0111\u1ebfn 4 n\u0103m, trong \u0111\u00f3 suy h\u00f4 h\u1ea5p l\u00e0 nguy\u00ean nh\u00e2n ch\u00ednh g\u00e2y t\u1eed vong. Hi\u1ec7n t\u1ea1i, kh\u00f4ng c\u00f3 li\u1ec7u ph\u00e1p n\u00e0o mang l\u1ea1i l\u1ee3i \u00edch l\u00e2m s\u00e0ng \u0111\u00e1ng k\u1ec3 cho b\u1ec7nh nh\u00e2n ALS, v\u00e0 c\u00e1c li\u1ec7u ph\u00e1p \u0111i\u1ec1u tr\u1ecb tri\u1ec7u ch\u1ee9ng k\u1ecbp th\u1eddi l\u00e0 c\u01a1 s\u1edf ch\u0103m s\u00f3c ch\u00ednh cho b\u1ec7nh nh\u00e2n ALS.\u00a0<\/span><\/p>\n

\"Ng\u01b0\u1eddi
Ng\u01b0\u1eddi m\u1eafc h\u1ed9i ch\u1ee9ng ALS th\u01b0\u1eddng g\u1eb7p kh\u00f3 kh\u0103n trong vi\u1ec7c \u0111i l\u1ea1i ho\u1eb7c th\u1ef1c hi\u1ec7n c\u00e1c ho\u1ea1t \u0111\u1ed9ng h\u00e0ng ng\u00e0y<\/figcaption><\/figure>\n

Cho t\u1edbi nay, nguy\u00ean nh\u00e2n g\u00e2y ra b\u1ec7nh x\u01a1 c\u1ee9ng teo c\u01a1 m\u1ed9t b\u00ean v\u1eabn ch\u01b0a \u0111\u01b0\u1ee3c nghi\u00ean c\u1ee9u \u0111\u1ea7y \u0111\u1ee7. M\u1ed9t s\u1ed1 tr\u01b0\u1eddng h\u1ee3p \u0111\u01b0\u1ee3c cho l\u00e0 do di truy\u1ec1n. C\u00e1c nghi\u00ean c\u1ee9u di truy\u1ec1n \u0111\u00e3 x\u00e1c \u0111\u1ecbnh h\u01a1n 20 gen li\u00ean quan \u0111\u1ebfn ALS k\u1ec3 t\u1eeb n\u0103m 1993, v\u1edbi c\u00e1c gen th\u01b0\u1eddng g\u1eb7p nh\u1ea5t l\u00e0 C9orf72 v\u00e0 \u0111\u1ed9t bi\u1ebfn trong gen SOD1, TARDBP v\u00e0 gen g\u1ed9p trong sarcoma. T\u1ea7n su\u1ea5t \u0111\u1ed9t bi\u1ebfn gen trong c\u00e1c tr\u01b0\u1eddng h\u1ee3p ALS kh\u00e1c nhau t\u00f9y thu\u1ed9c v\u00e0o v\u00f9ng \u0111\u1ecba l\u00fd v\u00e0 d\u00e2n t\u1ed9c. \u0110\u00e1nh gi\u00e1 to\u00e0n di\u1ec7n v\u00e0 ph\u00e2n t\u00edch k\u1ebft h\u1ee3p n\u00e0y nh\u1eb1m \u01b0\u1edbc t\u00ednh s\u1ed1 l\u01b0\u1ee3ng tr\u01b0\u1eddng h\u1ee3p c\u00f3 s\u1eb5n v\u00e0 m\u1edbi ph\u00e1t hi\u1ec7n c\u1ee7a ALS chung v\u00e0 ALS C9orf72 v\u00e0 SOD1 trong 22 qu\u1ed1c gia thu\u1ed9c c\u00e1c khu v\u1ef1c \u0111\u1ecba l\u00fd kh\u00e1c nhau tr\u00ean th\u1ebf gi\u1edbi.<\/span><\/p>\n

2. Thu\u1ed1c m\u1edbi Tofersen<\/b><\/h2>\n

2.1 Ch\u1ec9 \u0111\u1ecbnh<\/b><\/h3>\n

V\u00e0o ng\u00e0y 25 th\u00e1ng 4 n\u0103m 2023, Tofersen (ho\u1ea1t ch\u1ea5t ch\u00ednh c\u1ee7a Qalsody 100mg\/15mL) \u0111\u00e3 \u0111\u01b0\u1ee3c C\u1ee5c Qu\u1ea3n l\u00fd Th\u1ef1c ph\u1ea9m v\u00e0 D\u01b0\u1ee3c ph\u1ea9m Hoa K\u1ef3 (FDA)\u00a0 ph\u00ea duy\u1ec7t \u0111\u1ec3 \u0111i\u1ec1u tr\u1ecb x\u01a1 c\u1ee9ng teo c\u01a1 m\u1ed9t b\u00ean (ALS) \u1edf ng\u01b0\u1eddi tr\u01b0\u1edfng th\u00e0nh c\u00f3 \u0111\u1ed9t bi\u1ebfn gen superoxide dismutase 1 ( SOD1 ). Ch\u1ec9 \u0111\u1ecbnh n\u00e0y \u0111\u01b0\u1ee3c ph\u00ea duy\u1ec7t theo ph\u00ea duy\u1ec7t c\u1ea5p t\u1ed1c d\u1ef1a tr\u00ean vi\u1ec7c gi\u1ea3m NfL trong huy\u1ebft t\u01b0\u01a1ng \u0111\u01b0\u1ee3c quan s\u00e1t th\u1ea5y \u1edf nh\u1eefng b\u1ec7nh nh\u00e2n \u0111\u01b0\u1ee3c \u0111i\u1ec1u tr\u1ecb b\u1eb1ng Qalsody.\u00a0<\/span><\/p>\n

\"Qalsody
\u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 Qalsody (Tofersen)\u00a0<\/figcaption><\/figure>\n

2.2 Th\u00f4ng tin v\u1ec1 li\u1ec1u d\u00f9ng<\/b><\/h3>\n
    \n
  • Li\u1ec1u khuy\u1ebfn ngh\u1ecb<\/span><\/li>\n<\/ul>\n

    Ti\u00eam Qalsody v\u00e0o h\u1ea1ch t\u1ee7y b\u1eb1ng c\u00e1ch s\u1eed d\u1ee5ng th\u1ee7 thu\u1eadt ch\u1ecdc l\u1ed7 th\u1eaft l\u01b0ng b\u1edfi c\u00e1c chuy\u00ean gia y t\u1ebf c\u00f3 kinh nghi\u1ec7m.<\/span><\/p>\n

    Li\u1ec1u khuy\u1ebfn ngh\u1ecb l\u00e0 100 mg (15 mL) c\u1ee7a Qalsody m\u1ed7i l\u1ea7n ti\u00eam<\/span><\/p>\n

    B\u1eaft \u0111\u1ea7u \u0111i\u1ec1u tr\u1ecb Qalsody v\u1edbi ba li\u1ec1u t\u1ea3i \u0111\u01b0\u1ee3c ti\u00eam v\u00e0o kho\u1ea3ng c\u00e1ch 14 ng\u00e0y.<\/span><\/p>\n

    Ti\u00eam li\u1ec1u duy tr\u00ec m\u1ed7i 28 ng\u00e0y sau \u0111\u00f3.<\/span><\/p>\n

      \n
    • N\u1ebfu b\u1ecf qu\u00ean li\u1ec1u<\/span><\/li>\n<\/ul>\n

      N\u1ebfu b\u1ecf qu\u00ean li\u1ec1u g\u1ed1c th\u1ee9 hai, ti\u00eam Qalsody c\u00e0ng s\u1edbm c\u00e0ng t\u1ed1t v\u00e0 ti\u00eam li\u1ec1u t\u1ea3i th\u1ee9 ba sau 14 ng\u00e0y.<\/span><\/p>\n

      N\u1ebfu b\u1ecf qu\u00ean li\u1ec1u g\u1ed1c th\u1ee9 ba ho\u1eb7c li\u1ec1u duy tr\u00ec, ti\u00eam Qalsody c\u00e0ng s\u1edbm c\u00e0ng t\u1ed1t v\u00e0 ti\u00eam li\u1ec1u ti\u1ebfp theo sau 28 ng\u00e0y.<\/span><\/p>\n

      2.4 D\u01b0\u1ee3c \u0111\u1ed9ng h\u1ecdc<\/b><\/h3>\n

      H\u1ea5p thu:\u00a0<\/i><\/b><\/h4>\n

      Vi\u1ec7c ti\u00eam v\u00e0o CSF c\u1ee7a Qalsody cho ph\u00e9p Tofersen \u0111\u01b0\u1ee3c ph\u00e2n ph\u1ed1i t\u1eeb CSF \u0111\u1ebfn c\u00e1c m\u00f4 trong h\u1ec7 th\u1ed1ng th\u1ea7n kinh trung \u01b0\u01a1ng. N\u1ed3ng \u0111\u1ed9 th\u1ea5p nh\u1ea5t c\u1ee7a Tofersen trong CSF xu\u1ea5t hi\u1ec7n \u1edf li\u1ec1u th\u1ee9 ba, \u0111\u00f3 l\u00e0 li\u1ec1u cu\u1ed1i c\u00f9ng c\u1ee7a giai \u0111o\u1ea1n t\u1ea3i n\u1ea1p. Sau giai \u0111o\u1ea1n t\u1ea3i n\u1ea1p, kh\u00f4ng c\u00f3 t\u00edch t\u1ee5 nhi\u1ec1u ho\u1eb7c kh\u00f4ng t\u00edch t\u1ee5 Tofersen trong CSF v\u1edbi li\u1ec1u duy tr\u00ec h\u00e0ng th\u00e1ng. Tofersen \u0111\u01b0\u1ee3c chuy\u1ec3n t\u1eeb CSF v\u00e0o tu\u1ea7n ho\u00e0n h\u1ec7 th\u1ed1ng, v\u1edbi th\u1eddi gian \u0111\u1ebfn n\u1ed3ng \u0111\u1ed9 t\u1ed1i \u0111a trung b\u00ecnh (Tmax) trong huy\u1ebft t\u01b0\u01a1ng dao \u0111\u1ed9ng t\u1eeb 2 \u0111\u1ebfn 6 gi\u1edd. Kh\u00f4ng c\u00f3 s\u1ef1 t\u00edch t\u1ee5 n\u00e0o c\u1ee7a Tofersen trong huy\u1ebft t\u01b0\u01a1ng sau li\u1ec1u duy tr\u00ec h\u00e0ng th\u00e1ng.<\/span><\/p>\n

      Ph\u00e2n b\u1ed1<\/i><\/b><\/h4>\n

      Qua kh\u1ea3o s\u00e1t b\u1ec7nh nh\u00e2n \u0111\u01b0\u1ee3c \u0111i\u1ec1u tr\u1ecb b\u1eb1ng thu\u1ed1c cho th\u1ea5y r\u1eb1ng Tofersen \u0111\u01b0\u1ee3c ti\u00eam v\u00e0o t\u1ee7y s\u1ed1ng \u0111\u01b0\u1ee3c ph\u00e2n b\u1ed1 trong c\u00e1c m\u00f4 trong h\u1ec7 th\u1ed1ng th\u1ea7n kinh trung \u01b0\u01a1ng.<\/span><\/p>\n

      Chuy\u1ec3n h\u00f3a<\/i><\/b><\/h4>\n

      \u200b\u200bTofersen s\u1ebd \u0111\u01b0\u1ee3c chuy\u1ec3n h\u00f3a th\u00f4ng qua qu\u00e1 tr\u00ecnh th\u1ee7y ph\u00e2n trung gian exonuclease (3 ‘- v\u00e0 5’)\u00a0<\/span><\/p>\n

      Th\u1ea3i tr\u1eeb<\/i><\/b><\/h4>\n

      Con \u0111\u01b0\u1eddng ch\u00ednh c\u1ee7a qu\u00e1 tr\u00ecnh b\u00e0i ti\u1ebft ch\u01b0a \u0111\u01b0\u1ee3c x\u00e1c \u0111\u1ecbnh. s=Sau 4 tu\u1ea7n, ch\u1ec9 c\u00f2n l\u1ea1i m\u1ed9t n\u1eeda li\u1ec1u thu\u1ed1c ban \u0111\u1ea7u trong CSF<\/span><\/p>\n

      D\u00e2n s\u1ed1 c\u1ee5 th\u1ec3<\/i><\/b><\/h4>\n

      T\u00e1c \u0111\u1ed9ng c\u1ee7a gi\u1edbi t\u00ednh, ch\u1ee7ng t\u1ed9c, tu\u1ed5i v\u00e0 c\u00e2n n\u1eb7ng \u0111\u1ebfn ti\u1ebfp x\u00fac Tofersen trong huy\u1ebft t\u01b0\u01a1ng kh\u00f4ng c\u00f3 \u00fd ngh\u0129a l\u00e2m s\u00e0ng. T\u00e1c \u0111\u1ed9ng c\u1ee7a c\u00e1c y\u1ebfu t\u1ed1 n\u00e0y \u0111\u1ed1i v\u1edbi ti\u1ebfp x\u00fac Tofersen trong CSF ch\u01b0a \u0111\u01b0\u1ee3c bi\u1ebft.<\/span><\/p>\n

      B\u1ec7nh nh\u00e2n suy th\u1eadn ho\u1eb7c suy gan<\/i><\/b><\/h4>\n

      Ch\u01b0a c\u00f3 nghi\u00ean c\u1ee9u l\u00e2m s\u00e0ng n\u00e0o \u0111\u01b0\u1ee3c ti\u1ebfn h\u00e0nh \u0111\u1ec3 \u0111\u00e1nh gi\u00e1 d\u01b0\u1ee3c \u0111\u1ed9ng h\u1ecdc c\u1ee7a Tofersen \u1edf b\u1ec7nh nh\u00e2n suy th\u1eadn ho\u1eb7c suy gan. Tofersen \u0111\u01b0\u1ee3c d\u1ef1 ki\u1ebfn s\u1ebd kh\u00f4ng chuy\u1ec3n h\u00f3a qua men gan\u00a0<\/span><\/p>\n

      2.6 C\u1ea3nh b\u00e1o v\u00e0 \u0111\u1ec1 ph\u00f2ng<\/b><\/h3>\n

      Th\u00f4ng tin quan tr\u1ecdng nh\u1ea5t v\u1ec1 Qalsody l\u00e0 Qalsody c\u00f3 th\u1ec3 g\u00e2y ra t\u00e1c d\u1ee5ng ph\u1ee5 nghi\u00eam tr\u1ecdng, bao g\u1ed3m:<\/span><\/p>\n

        \n
      • Vi\u00eam t\u1ee7y s\u1ed1ng v\u00e0\/ho\u1eb7c vi\u00eam d\u00e2y th\u1ea7n kinh c\u1ed9t s\u1ed1ng: 6 b\u1ec7nh nh\u00e2n \u0111\u01b0\u1ee3c \u0111i\u1ec1u tr\u1ecb v\u1edbi Qalsody \u0111\u00e3 g\u1eb7p ph\u1ea3i vi\u00eam t\u1ee7y s\u1ed1ng ho\u1eb7c vi\u00eam d\u00e2y th\u1ea7n kinh c\u1ed9t s\u1ed1ng trong c\u00e1c nghi\u00ean c\u1ee9u l\u00e2m s\u00e0ng. 2 b\u1ec7nh nh\u00e2n \u0111\u00e3 ng\u1eebng \u0111i\u1ec1u tr\u1ecb v\u1edbi Qalsody v\u00ec c\u1ea7n ki\u1ec3m so\u00e1t tri\u1ec7u ch\u1ee9ng. \u1ede 4 b\u1ec7nh nh\u00e2n c\u00f2n l\u1ea1i, tri\u1ec7u ch\u1ee9ng \u0111\u01b0\u1ee3c gi\u1ea3i quy\u1ebft m\u00e0 kh\u00f4ng c\u1ea7n ng\u1eebng s\u1eed d\u1ee5ng Qalsody.\u00a0<\/span><\/li>\n
      • Ph\u00f9 gai th\u1ecb (Papilledema) v\u00e0 t\u0103ng \u00e1p l\u1ef1c n\u1ed9i s\u1ecd: 4 b\u1ec7nh nh\u00e2n \u0111\u00e3 ph\u00e1t tri\u1ec3n b\u1ec7nh n\u00e0y, t\u1ea5t c\u1ea3 b\u1ec7nh nh\u00e2n \u0111\u00e3 \u0111\u01b0\u1ee3c \u0111i\u1ec1u tr\u1ecb theo chu\u1ea9n ch\u0103m s\u00f3c y t\u1ebf \u0111\u1ec3 gi\u1ea3i quy\u1ebft tri\u1ec7u ch\u1ee9ng v\u00e0 kh\u00f4ng c\u00f3 s\u1ef1 ti\u1ebfn tri\u1ec3n n\u00e0o nghi\u00eam tr\u1ecdng c\u1ee7a b\u1ec7nh d\u1eabn \u0111\u1ebfn ng\u1eebng s\u1eed d\u1ee5ng Qalsody.\u00a0<\/span><\/li>\n
      • Vi\u00eam m\u00e0ng n\u00e3o: 1 b\u1ec7nh nh\u00e2n \u0111\u00e3 g\u1eb7p ph\u1ea3n \u1ee9ng nghi\u00eam tr\u1ecdng c\u1ee7a vi\u00eam m\u00e0ng n\u00e3o, d\u1eabn \u0111\u1ebfn ng\u1eebng s\u1eed d\u1ee5ng Qalsody. 1 b\u1ec7nh nh\u00e2n \u0111\u00e3 g\u1eb7p ph\u1ea3n \u1ee9ng nghi\u00eam tr\u1ecdng b\u1ec7nh n\u00e0y, nh\u01b0ng kh\u00f4ng d\u1eabn \u0111\u1ebfn ng\u1eebng s\u1eed d\u1ee5ng Qalsody. Ngo\u00e0i ra, c\u00e1c ph\u1ea3n \u1ee9ng ph\u1ee5 kh\u00f4ng nghi\u00eam tr\u1ecdng c\u1ee7a t\u0103ng b\u1ea1ch c\u1ea7u trong d\u1ecbch t\u1ee7y s\u1ed1ng v\u00e0 t\u0103ng protein trong d\u1ecbch t\u1ee7y s\u1ed1ng c\u0169ng \u0111\u00e3 \u0111\u01b0\u1ee3c b\u00e1o c\u00e1o v\u1edbi Qalsody.\u00a0<\/span><\/li>\n<\/ul>\n

        N\u1ebfu c\u00f3 tri\u1ec7u ch\u1ee9ng t\u01b0\u01a1ng t\u1ef1 v\u1edbi nh\u1eefng b\u1ec7nh l\u00fd tr\u00ean, c\u1ea7n ti\u1ebfn h\u00e0nh c\u00e1c x\u00e9t nghi\u1ec7m ch\u1ea9n \u0111o\u00e1n v\u00e0 \u0111i\u1ec1u tr\u1ecb theo chu\u1ea9n ch\u0103m s\u00f3c y t\u1ebf.<\/span><\/p>\n

        2.7 T\u00e1c d\u1ee5ng ph\u1ee5<\/b><\/h3>\n

        C\u00e1c ph\u1ea3n \u1ee9ng b\u1ea5t l\u1ee3i ph\u1ed5 bi\u1ebfn nh\u1ea5t \u0111\u01b0\u1ee3c b\u00e1o c\u00e1o \u1edf nh\u1eefng b\u1ec7nh nh\u00e2n \u0111\u01b0\u1ee3c \u0111i\u1ec1u tr\u1ecb b\u1eb1ng Qalsody l\u00e0 \u0111au (\u0111au l\u01b0ng, \u0111au \u1edf c\u00e1nh tay ho\u1eb7c ch\u00e2n), c\u1ea3m th\u1ea5y m\u1ec7t m\u1ecfi, \u0111au c\u01a1 v\u00e0 kh\u1edbp v\u00e0 t\u0103ng s\u1ed1 l\u01b0\u1ee3ng b\u1ea1ch c\u1ea7u trong d\u1ecbch n\u00e3o t\u1ee7y (CSF).<\/span><\/p>\n

        2.8 T\u01b0\u01a1ng t\u00e1c thu\u1ed1c<\/b><\/h3>\n

        Ch\u01b0a c\u00f3 nghi\u00ean c\u1ee9u t\u01b0\u01a1ng t\u00e1c thu\u1ed1c l\u00e2m s\u00e0ng n\u00e0o \u0111\u01b0\u1ee3c th\u1ef1c hi\u1ec7n v\u00ec Qalsody kh\u00f4ng \u0111\u00f3ng vai tr\u00f2 l\u00e0 ch\u1ea5t chuy\u1ec3n h\u00f3a, ch\u1ea5t \u1ee9c ch\u1ebf hay k\u00edch th\u00edch c\u00e1c men CYP ch\u00ednh ho\u1eb7c ch\u1ea5t chuy\u1ec3n v\u1eadn.<\/span><\/p>\n","protected":false},"excerpt":{"rendered":"

        Tofersen l\u00e0 m\u1ed9t lo\u1ea1i thu\u1ed1c m\u1edbi \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng \u0111\u1ec3 \u0111i\u1ec1u tr\u1ecb b\u1ec7nh x\u01a1 c\u1ee9ng teo c\u01a1 m\u1ed9t b\u00ean (SOD1-ALS), m\u1ed9t c\u0103n b\u1ec7nh th\u1ea7n kinh ti\u1ebfn tri\u1ec3n nhanh v\u00e0 g\u00e2y ra kh\u00f3 kh\u0103n trong vi\u1ec7c \u0111i l\u1ea1i, n\u00f3i chuy\u1ec7n v\u00e0 th\u1edf. Thu\u1ed1c \u0111\u01b0\u1ee3c ti\u00eam tr\u1ef1c ti\u1ebfp v\u00e0o d\u1ecbch n\u00e3o t\u1ee7y (CSF), cho ph\u00e9p ph\u00e2n ph\u1ed1i […]<\/p>\n","protected":false},"author":53,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[12],"tags":[],"yoast_head":"\nTofersen thu\u1ed1c m\u1edbi \u0111i\u1ec1u tr\u1ecb b\u1ec7nh x\u01a1 c\u1ee9ng teo c\u01a1 m\u1ed9t b\u00ean - Vinmec<\/title>\n<meta name=\"description\" content=\"Tofersen l\u00e0 m\u1ed9t lo\u1ea1i thu\u1ed1c m\u1edbi \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng \u0111\u1ec3 \u0111i\u1ec1u tr\u1ecb b\u1ec7nh x\u01a1 c\u1ee9ng teo c\u01a1 m\u1ed9t b\u00ean, m\u1ed9t c\u0103n b\u1ec7nh th\u1ea7n kinh ti\u1ebfn tri\u1ec3n nhanh,\" \/>\n<meta name=\"robots\" content=\"noindex, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Tofersen thu\u1ed1c m\u1edbi \u0111i\u1ec1u tr\u1ecb b\u1ec7nh x\u01a1 c\u1ee9ng teo c\u01a1 m\u1ed9t b\u00ean - 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