{"id":28863,"date":"2023-05-06T12:00:33","date_gmt":"2023-05-06T05:00:33","guid":{"rendered":"http:\/\/noithathoaphat.in\/ctv\/?p=28863"},"modified":"2023-05-06T12:00:33","modified_gmt":"2023-05-06T05:00:33","slug":"voxzogo-vosoritide-trong-dieu-tri-loan-san-sun-achondroplasia","status":"publish","type":"post","link":"http:\/\/noithathoaphat.in\/ctv\/index.php\/2023\/05\/06\/voxzogo-vosoritide-trong-dieu-tri-loan-san-sun-achondroplasia\/","title":{"rendered":"Voxzogo (Vosoritide) trong \u0111i\u1ec1u tr\u1ecb lo\u1ea1n s\u1ea3n s\u1ee5n (Achondroplasia)"},"content":{"rendered":"

Lo\u1ea1n s\u1ea3n s\u1ee5n l\u00e0 m\u1ed9t b\u1ec7nh di truy\u1ec1n g\u00e2y ra s\u1ef1 t\u0103ng tr\u01b0\u1edfng b\u1ea5t th\u01b0\u1eddng c\u1ee7a x\u01b0\u01a1ng, d\u1eabn \u0111\u1ebfn s\u1ef1 c\u1eadn t\u00ednh c\u1ee7a chi\u1ec1u cao v\u00e0 c\u00e1c v\u1ea5n \u0111\u1ec1 s\u1ee9c kh\u1ecfe kh\u00e1c. Hi\u1ec7n nay, Voxzogo (hay c\u00f2n g\u1ecdi l\u00e0 Vosoritide) l\u00e0 m\u1ed9t lo\u1ea1i thu\u1ed1c m\u1edbi \u0111\u01b0\u1ee3c ph\u00e1t tri\u1ec3n \u0111\u1ec3 \u0111i\u1ec1u tr\u1ecb b\u1ec7nh lo\u1ea1n s\u1ea3n s\u1ee5n\u00a0<\/span><\/strong><\/p>\n

1.T\u00ecm hi\u1ec3u v\u1ec1 b\u1ec7nh Lo\u1ea1n S\u1ea3n S\u1ee5n (Achondroplasia)<\/strong><\/h2>\n

Lo\u1ea1n s\u1ea3n s\u1ee5n<\/a> l\u00e0 m\u1ed9t r\u1ed1i lo\u1ea1n ph\u00e1t tri\u1ec3n x\u01b0\u01a1ng l\u00e0m ng\u0103n ch\u1eb7n s\u1ef1 thay \u0111\u1ed5i c\u1ee7a s\u1ee5n (\u0111\u1eb7c bi\u1ec7t l\u00e0 \u1edf x\u01b0\u01a1ng d\u00e0i c\u1ee7a c\u00e1nh tay v\u00e0 ch\u00e2n) trong qu\u00e1 tr\u00ecnh t\u1ea1o th\u00e0nh x\u01b0\u01a1ng. Lo\u1ea1n s\u1ea3n s\u1ee5n \u0111\u1eb7c tr\u01b0ng b\u1edfi tri\u1ec7u ch\u1ee9ng h\u1ea1n ch\u1ebf chuy\u1ec3n \u0111\u1ed9ng \u1edf khu\u1ef7u tay, ng\u00f3n tay. Lo\u1ea1n s\u1ea3n s\u1ee5n \u0111\u01b0\u1ee3c th\u1ed1ng k\u00ea x\u1ea3y ra v\u1edbi t\u1ec9 l\u1ec7 kho\u1ea3ng 1 tr\u00ean 20000-30000 ng\u01b0\u1eddi b\u00ecnh th\u01b0\u1eddng. Lo\u1ea1n s\u1ea3n s\u1ee5n x\u1ea3y ra do \u0111\u1ed9t bi\u1ebfn gen t\u1ef1 ph\u00e1t \u1edf kho\u1ea3ng 80% b\u1ec7nh nh\u00e2n v\u00e0 20% do di truy\u1ec1n. Lo\u1ea1n s\u1ea3n s\u1ee5n th\u01b0\u1eddng kh\u00f4ng g\u00e2y suy gi\u1ea3m tinh th\u1ea7n v\u00e0 tu\u1ed5i th\u1ecd g\u1ea7n nh\u01b0 b\u00ecnh th\u01b0\u1eddng trong c\u00e1c tr\u01b0\u1eddng h\u1ee3p x\u01b0\u01a1ng n\u1ed1i \u0111\u1ea7u v\u00e0 c\u1ed5 kh\u00f4ng ch\u00e8n \u00e9p th\u00e2n n\u00e3o ho\u1eb7c ph\u1ea7n tr\u00ean c\u1ee7a t\u1ee7y s\u1ed1ng<\/span><\/p>\n

\"Lo\u1ea1n
Lo\u1ea1n s\u1ea3n s\u1ee5n<\/figcaption><\/figure>\n

1.1 Nguy\u00ean nh\u00e2n\u00a0<\/span><\/h3>\n

Lo\u1ea1n s\u1ea3n s\u1ee5n l\u00e0 m\u1ed9t b\u1ec7nh di truy\u1ec1n g\u00e2y ra b\u1edfi ho\u1ea1t \u0111\u1ed9ng c\u1ee7a m\u1ed9t ho\u1eb7c nhi\u1ec1u gen kh\u00f4ng b\u00ecnh th\u01b0\u1eddng, th\u01b0\u1eddng l\u00e0 do \u0111\u1ed9t bi\u1ebfn gen FGFR3. Trong giai \u0111o\u1ea1n \u0111\u1ea7u ph\u00e1t tri\u1ec3n c\u1ee7a b\u00e0o thai, ph\u1ea7n l\u1edbn x\u01b0\u01a1ng \u0111\u01b0\u1ee3c t\u1ea1o th\u00e0nh t\u1eeb s\u1ee5n. Th\u00f4ng th\u01b0\u1eddng, h\u1ea7u h\u1ebft s\u1ee5n s\u1ebd chuy\u1ec3n th\u00e0nh x\u01b0\u01a1ng trong qu\u00e1 tr\u00ecnh tr\u01b0\u1edfng th\u00e0nh. Tuy nhi\u00ean, r\u1ea5t nhi\u1ec1u s\u1ee5n kh\u00f4ng th\u1ec3 chuy\u1ec3n h\u00f3a th\u00e0nh x\u01b0\u01a1ng do \u0111\u1ed9t bi\u1ebfn gen FGFR3 kh\u00f4ng t\u1ea1o \u0111\u01b0\u1ee3c protein v\u00e0 c\u1ea3n tr\u1edf s\u1ef1 ph\u00e1t tri\u1ec3n b\u00ecnh th\u01b0\u1eddng c\u1ee7a x\u01b0\u01a1ng<\/span><\/p>\n

1.2 Tri\u1ec7u ch\u1ee9ng\u00a0<\/span><\/h3>\n

Nh\u1eefng tri\u1ec7u ch\u1ee9ng ph\u1ed5 bi\u1ebfn c\u1ee7a b\u1ec7nh lo\u1ea1n s\u1ea3n s\u1ee5n bao g\u1ed3m: (1) tay v\u00e0 ch\u00e2n ng\u1eafn l\u1ea1i (2) k\u00edch th\u01b0\u1edbc \u0111\u1ea7u l\u1edbn v\u00e0 v\u1ea7ng tr\u00e1n n\u1ed5i b\u1eadt v\u1edbi s\u1ed1ng m\u0169i t\u1eb9t (3) r\u0103ng m\u1ecdc chen ch\u00fac ho\u1eb7c m\u1ecdc l\u1ec7ch (4) c\u1ed9t s\u1ed1ng cong (g\u00f9 l\u01b0ng) (5) c\u00e1c \u1ed1ng \u0111\u1ed1t nh\u1ecf d\u1eabn \u0111\u1ebfn ch\u00e8n \u00e9p t\u1ee7y s\u1ed1ng (6) khu\u1ef5u ch\u00e2n (6) nhi\u1ec5m tr\u00f9ng tai gi\u1eefa (7) b\u00e0n ch\u00e2n ph\u1eb3ng ng\u1eafn v\u00e0 r\u1ed9ng (8) c\u01a1 b\u1eafp k\u00e9m ph\u00e1t tri\u1ec3n\u00a0<\/span><\/p>\n

Ph\u1ea7n l\u1edbn nh\u1eefng ng\u01b0\u1eddi m\u1eafc b\u1ec7nh c\u00f3 tu\u1ed5i th\u1ecd v\u00e0 tr\u00ed th\u00f4ng minh ph\u00e1t tri\u1ec3n b\u00ecnh th\u01b0\u1eddng b\u1ea5t k\u1ec3 s\u1ef1 ph\u00e1t tri\u1ec3n ch\u1eadm \u1edf tr\u1ebb s\u01a1 sinh. M\u1eb7c d\u00f9 c\u00f3 th\u1ec3 x\u1ea3y ra c\u00e1c bi\u1ebfn ch\u1ee9ng do ch\u1ee9ng lo\u1ea1n s\u1ea3n s\u1ee5n, nh\u01b0ng vi\u1ec7c ch\u0103m s\u00f3c \u0111\u1ec3 c\u1ea3i thi\u1ec7n c\u00e1c tri\u1ec7u ch\u1ee9ng c\u00f3 th\u1ec3 gi\u00fap ng\u0103n ng\u1eeba c\u00e1c v\u1ea5n \u0111\u1ec1 s\u1ee9c kh\u1ecfe nghi\u00eam tr\u1ecdng x\u1ea3y ra sau n\u00e0y trong cu\u1ed9c s\u1ed1ng<\/span><\/p>\n

1.3 Ch\u1ea9n \u0111o\u00e1n\u00a0<\/span><\/h3>\n

B\u1ec7nh lo\u1ea1n s\u1ea3n s\u1ee5n c\u00f3 th\u1ec3 \u0111\u01b0\u1ee3c ch\u1ea9n \u0111o\u00e1n tr\u01b0\u1edbc khi sinh b\u1eb1ng si\u00eau \u00e2m thai nhi ho\u1eb7c sau khi sinh th\u00f4ng qua th\u0103m kh\u00e1m l\u00e2m s\u00e0ng. X\u00e9t nghi\u1ec7m ADN tr\u01b0\u1edbc khi sinh \u0111\u1ec3 x\u00e1c nh\u1eadn k\u1ebft qu\u1ea3 si\u00eau \u00e2m thai nhi cho c\u00e1c b\u1eadc cha m\u1eb9 c\u00f3 nguy c\u01a1 cao sinh con b\u1ecb ch\u1ee9ng lo\u1ea1n s\u1ea3n s\u1ee5n. Ngo\u00e0i ra, ch\u1ee5p MRI ho\u1eb7c ch\u1ee5p CT c\u00f3 th\u1ec3 x\u00e1c \u0111\u1ecbnh y\u1ebfu c\u01a1 ho\u1eb7c ch\u00e8n \u00e9p t\u1ee7y s\u1ed1ng<\/span><\/p>\n

1.4 \u0110i\u1ec1u tr\u1ecb\u00a0<\/span><\/h3>\n

Kh\u00f4ng c\u00f3 ph\u01b0\u01a1ng ph\u00e1p \u0111i\u1ec1u tr\u1ecb c\u1ee5 th\u1ec3 n\u00e0o cho ch\u1ee9ng lo\u1ea1n s\u1ea3n s\u1ee5n ngo\u00e0i vi\u1ec7c ki\u1ec3m so\u00e1t c\u00e1c tri\u1ec7u ch\u1ee9ng. Theo d\u00f5i chi\u1ec1u cao, c\u00e2n n\u1eb7ng v\u00e0 v\u00f2ng \u0111\u1ea7u \u0111\u01b0\u1ee3c khuy\u1ebfn ngh\u1ecb trong qu\u00e1 tr\u00ecnh ch\u1ea9n \u0111o\u00e1n s\u1edbm \u1edf tr\u1ebb s\u01a1 sinh \u0111\u1ec3 theo d\u00f5i ti\u1ebfn tr\u00ecnh t\u0103ng tr\u01b0\u1edfng.<\/span><\/p>\n

C\u00e1c c\u00e1ch ki\u1ec3m so\u00e1t tri\u1ec7u ch\u1ee9ng trong b\u1ec7nh lo\u1ea1n s\u1ea3n s\u1ee5n<\/span><\/p>\n

    \n
  • Qu\u1ea3n l\u00fd c\u00e2n n\u1eb7ng v\u00e0 khuy\u1ebfn kh\u00edch th\u00f3i quen \u0103n u\u1ed1ng l\u00e0nh m\u1ea1nh \u0111\u1ec3 ng\u0103n ng\u1eeba b\u00e9o ph\u00ec<\/span><\/li>\n
  • Ph\u1eabu thu\u1eadt (Shunt n\u00e3o th\u1ea5t m\u00e0ng b\u1ee5ng) \u0111\u1ec3 gi\u1ea3m \u00e1p l\u1ef1c d\u1ecbch l\u00ean n\u00e3o ho\u1eb7c \u0111\u1ec3 kh\u1eafc ph\u1ee5c bi\u1ebfn ch\u1ee9ng ch\u00e8n \u00e9p kh\u1edbp s\u1ecd c\u1ed5 t\u1eed cung\u00a0<\/span><\/li>\n
  • D\u00f9ng thu\u1ed1c kh\u00e1ng sinh ng\u0103n ng\u1eeba nhi\u1ec5m tr\u00f9ng tai\u00a0<\/span><\/li>\n
  • S\u1eed d\u1ee5ng m\u1eb7t n\u1ea1 m\u00e1y tr\u1ee3 th\u1edf (CPAP) cho tri\u1ec7u ch\u1ee9ng ng\u01b0ng th\u1edf<\/span><\/li>\n<\/ul>\n

    2.T\u1ed5ng quan v\u1ec1 thu\u1ed1c Voxzogo (Vosoritide) trong \u0111i\u1ec1u tr\u1ecb lo\u1ea1n s\u1ea3n s\u1ee5n<\/strong><\/h2>\n

    2.1 Nh\u00f3m d\u01b0\u1ee3c l\u00fd v\u00e0 ch\u1ec9 \u0111\u1ecbnh s\u1eed d\u1ee5ng\u00a0<\/span><\/h3>\n

    Voxzogo (Vosoritide) l\u00e0 lo\u1ea1i thu\u1ed1c \u0111\u1ea7u ti\u00ean \u0111\u01b0\u1ee3c ch\u1ea5p thu\u1eadn \u0111\u1ec3 \u0111i\u1ec1u tr\u1ecb ch\u1ee9ng lo\u1ea1n s\u1ea3n s\u1ee5n cho tr\u1ebb em tr\u00ean 5 tu\u1ed5i. Voxzogo thu\u1ed9c nh\u00f3m thu\u1ed1c g\u1ecdi l\u00e0 C-Type Natriuretic Peptide v\u00e0 c\u00f3 th\u1ec3 \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng m\u1ed9t m\u00ecnh ho\u1eb7c ph\u1ed1i h\u1ee3p v\u1edbi c\u00e1c lo\u1ea1i thu\u1ed1c kh\u00e1c<\/span><\/p>\n

    \"Voxzogo
    Voxzogo (Vosoritide)<\/figcaption><\/figure>\n

    2.2 C\u01a1 ch\u1ebf ho\u1ea1t \u0111\u1ed9ng\u00a0<\/span><\/h3>\n

    B\u1ec7nh lo\u1ea1n s\u1ea3n s\u1ee5n l\u00e0 m\u1ed9t b\u1ec7nh b\u1ea9m sinh do \u0111\u1ed9t bi\u1ebfn sai ngh\u0129a c\u1ee7a gen FGFR3 d\u1eabn \u0111\u1ebfn t\u0103ng ch\u1ee9c n\u0103ng \u0111i\u1ec1u ch\u1ec9nh s\u1ef1 ph\u00e1t tri\u1ec3n c\u1ee7a x\u01b0\u01a1ng n\u1ed9i s\u1ee5n. Trong \u0111i\u1ec1u ki\u1ec7n b\u00ecnh th\u01b0\u1eddng, FGFR3 \u0111\u01b0\u1ee3c bi\u1ec3u hi\u1ec7n trong c\u1ea3 qu\u00e1 tr\u00ecnh ph\u00e1t tri\u1ec3n ph\u00f4i thai v\u00e0 sau khi sinh, nh\u01b0ng \u0111\u00f3ng vai tr\u00f2 kh\u00e1c nhau trong m\u1ed7i giai \u0111o\u1ea1n. Trong qu\u00e1 tr\u00ecnh ph\u00e1t tri\u1ec3n, gen FGFR3 th\u00fac \u0111\u1ea9y s\u1ef1 t\u0103ng sinh c\u1ee7a t\u1ebf b\u00e0o s\u1ee5n do \u0111\u00f3 Vosoritide \u0111\u00f3ng vai tr\u00f2 ch\u1ea5t t\u01b0\u01a1ng t\u1ef1 c\u1ee7a peptide b\u00e0i ni\u1ec7u Natri lo\u1ea1i C (CNP) (l\u00e0 ph\u00e2n t\u1eed truy\u1ec1n t\u00edn hi\u1ec7u k\u00edch th\u00edch t\u1ebf b\u00e0o s\u1ee5n ph\u00e1t tri\u1ec3n th\u00e0nh x\u01b0\u01a1ng d\u00e0i. S\u1ef1 g\u1eafn k\u1ebft ch\u1eb7t ch\u1ebd c\u1ee7a Vosoritide v\u1edbi th\u1ee5 th\u1ec3 NPR-B \u1ee9c ch\u1ebf RAF-1 v\u00e0 k\u00edch th\u00edch s\u1ef1 t\u0103ng sinh, bi\u1ec7t h\u00f3a c\u1ee7a t\u1ebf b\u00e0o s\u1ee5n.\u00a0<\/span><\/p>\n

    2.3 D\u01b0\u1ee3c \u0111\u1ed9ng h\u1ecdc c\u1ee7a thu\u1ed1c Voxzogo (Vosoritide)<\/span><\/h3>\n

    H\u1ea5p thu: \u1ede nh\u1eefng b\u1ec7nh nh\u00e2n \u0111\u01b0\u1ee3c ti\u00eam Vosoritide d\u01b0\u1edbi da h\u1eb1ng ng\u00e0y v\u1edbi li\u1ec1u 15mcg\/kg, Cmax n\u1eb1m trong kho\u1ea3ng 4,71-7,18 ng\/mL v\u00e0 AUC thu\u1ed9c kho\u1ea3ng 161-290 ng-min\/mL<\/span><\/p>\n

    Ph\u00e2n b\u1ed1: Th\u1ec3 t\u00edch ph\u00e2n b\u1ed1 sau khi ti\u00eam d\u01b0\u1edbi da 15mcg\/kg thu\u1ed9c kho\u1ea3ng 2880-3020mL\/kg<\/span><\/p>\n

    Chuy\u1ec3n h\u00f3a: Vosoritide c\u00f3 kh\u1ea3 n\u0103ng \u0111\u01b0\u1ee3c chuy\u1ec3n h\u00f3a th\u00f4ng qua con \u0111\u01b0\u1eddng d\u1ecb h\u00f3a th\u00e0nh c\u00e1c peptide v\u00e0 axit amin nh\u1ecf h\u01a1n<\/span><\/p>\n

    Th\u1ea3i tr\u1eeb: Th\u1eddi gian b\u00e1n h\u1ee7y (T1\/2) sau khi ti\u00eam 15mcg\/kg dao \u0111\u1ed9ng t\u1eeb 21-27,9 ph\u00fat v\u00e0 \u0111\u1ed9 thanh th\u1ea3i t\u1eeb 79,4-104mL\/ph\u00fat\/kg<\/span><\/p>\n

    2.4 T\u00e1c d\u1ee5ng ph\u1ee5\u00a0<\/span><\/h3>\n

    Vosoritide c\u00f3 th\u1ec3 g\u00e2y ra t\u00e1c d\u1ee5ng ph\u1ee5: m\u1ea9n \u0111\u1ecf, ph\u00e1t ban, bu\u1ed3n n\u00f4n, ch\u00f3ng m\u1eb7t, m\u1ec7t m\u1ecfi, n\u00f4n m\u1eeda, \u0111au b\u1ee5ng, ti\u00eau ch\u1ea3y, \u0111au tai, s\u1ed5 m\u0169i, \u0111au kh\u1edbp, da kh\u00f4,…<\/span><\/p>\n

    2.5 Li\u1ec1u d\u00f9ng\u00a0<\/span><\/h3>\n

    D\u1ea1ng b\u00e0o ch\u1ebf c\u1ee7a thu\u1ed1c Voxzogo (Vosoritide): vi\u00ean n\u00e9n 0,4mg ho\u1eb7c 0,56mg ho\u1eb7c 1,2mg<\/span><\/p>\n

    Li\u1ec1u l\u01b0\u1ee3ng khuy\u1ebfn c\u00e1o cho Voxzogo (Vosoritide): Tr\u1ebb em t\u1eeb 5 tu\u1ed5i tr\u1edf l\u00ean: li\u1ec1u th\u00f4ng th\u01b0\u1eddng n\u1eb1m trong kho\u1ea3ng 0,24-0,8mg ti\u00eam d\u01b0\u1edbi da x 1 l\u1ea7n\/ng\u00e0y\u00a0<\/span><\/p>\n

    3.\u01afu v\u00e0 nh\u01b0\u1ee3c \u0111i\u1ec3m c\u1ee7a Voxzogo (Vosoritide)<\/strong><\/h2>\n

    Khi s\u1eed d\u1ee5ng Vosoritide \u0111i\u1ec1u tr\u1ecb lo\u1ea1n s\u1ea3n s\u1ee5n, nh\u1eefng \u01b0u v\u00e0 nh\u01b0\u1ee3c \u0111i\u1ec3m \u0111\u01b0\u1ee3c ch\u1ee9ng minh qua nhi\u1ec1u nghi\u00ean c\u1ee9u nh\u01b0 sau:<\/p>\n\n\n\n\n\n\n
    \n

    \u01afu \u0111i\u1ec3m<\/b><\/p>\n<\/td>\n

    		\n

    Nh\u01b0\u1ee3c \u0111i\u1ec3m<\/b><\/p>\n<\/td>\n<\/tr>\n

    Thu\u1ed1c \u0111\u1ea7u ti\u00ean v\u00e0 duy nh\u1ea5t \u0111\u01b0\u1ee3c FDA ch\u1ea5p thu\u1eadn cho ch\u1ee9ng lo\u1ea1n s\u1ea3n s\u1ee5n<\/span><\/td>\nGi\u00e1 th\u00e0nh cao\u00a0<\/span><\/td>\n<\/tr>\n
    S\u1eed d\u1ee5ng 1 l\u1ea7n trong ng\u00e0y<\/span><\/td>\nC\u1ea7n pha v\u00e0 \u0111\u1ecbnh l\u01b0\u1ee3ng thu\u1ed1c tr\u01b0\u1edbc khi s\u1eed d\u1ee5ng n\u00ean c\u00f3 th\u1ec3 kh\u00f3 s\u1eed d\u1ee5ng\u00a0<\/span><\/td>\n<\/tr>\n
    C\u1ea3i thi\u1ec7n t\u1ed1c \u0111\u1ed9 t\u0103ng tr\u01b0\u1edfng \u1edf tr\u1ebb trong v\u00f2ng 2 n\u0103m\u00a0<\/span><\/td>\nKh\u00f4ng d\u00f9ng cho b\u1ec7nh nh\u00e2n b\u1ecb th\u1eadn n\u1eb7ng<\/span><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

     <\/p>\n","protected":false},"excerpt":{"rendered":"

    Lo\u1ea1n s\u1ea3n s\u1ee5n l\u00e0 m\u1ed9t b\u1ec7nh di truy\u1ec1n g\u00e2y ra s\u1ef1 t\u0103ng tr\u01b0\u1edfng b\u1ea5t th\u01b0\u1eddng c\u1ee7a x\u01b0\u01a1ng, d\u1eabn \u0111\u1ebfn s\u1ef1 c\u1eadn t\u00ednh c\u1ee7a chi\u1ec1u cao v\u00e0 c\u00e1c v\u1ea5n \u0111\u1ec1 s\u1ee9c kh\u1ecfe kh\u00e1c. Hi\u1ec7n nay, Voxzogo (hay c\u00f2n g\u1ecdi l\u00e0 Vosoritide) l\u00e0 m\u1ed9t lo\u1ea1i thu\u1ed1c m\u1edbi \u0111\u01b0\u1ee3c ph\u00e1t tri\u1ec3n \u0111\u1ec3 \u0111i\u1ec1u tr\u1ecb b\u1ec7nh lo\u1ea1n s\u1ea3n s\u1ee5n\u00a0 […]<\/p>\n","protected":false},"author":54,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[12],"tags":[],"yoast_head":"\nVoxzogo (Vosoritide) trong \u0111i\u1ec1u tr\u1ecb lo\u1ea1n s\u1ea3n s\u1ee5n (Achondroplasia)<\/title>\n<meta name=\"description\" content=\"Vosoritide \u0111\u01b0\u1ee3c FDA ch\u1ea5p thu\u1eadn \u0111\u1ec3 \u0111i\u1ec1u tr\u1ecb b\u1ec7nh lo\u1ea1n s\u1ea3n s\u1ee5n \u1edf \u0111\u1ed1i t\u01b0\u1ee3ng b\u1ec7nh nhi tr\u00ean 5 tu\u1ed5i. 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