{"id":28511,"date":"2023-04-26T07:24:26","date_gmt":"2023-04-26T00:24:26","guid":{"rendered":"http:\/\/noithathoaphat.in\/ctv\/?p=28511"},"modified":"2023-05-02T08:38:05","modified_gmt":"2023-05-02T01:38:05","slug":"yeu-to-toan-than-anh-huong-toi-benh-ly-tuy-rang","status":"publish","type":"post","link":"http:\/\/noithathoaphat.in\/ctv\/index.php\/2023\/04\/26\/yeu-to-toan-than-anh-huong-toi-benh-ly-tuy-rang\/","title":{"rendered":"Y\u1ebfu t\u1ed1 to\u00e0n th\u00e2n \u1ea3nh h\u01b0\u1edfng t\u1edbi b\u1ec7nh l\u00fd tu\u1ef7 r\u0103ng."},"content":{"rendered":"

B\u00e0i vi\u1ebft n\u00e0y n\u00f3i v\u1ec1 c\u00e1c y\u1ebfu t\u1ed1 to\u00e0n th\u00e2n v\u00e0 s\u1ef1 \u1ea3nh h\u01b0\u1edfng c\u1ee7a ch\u00fang t\u1edbi nh\u00f3m b\u1ec7nh l\u00fd tu\u1ef7 r\u0103ng. C\u00e1c y\u1ebfu t\u1ed1 to\u00e0n th\u00e2n c\u00f3 th\u1ec3 k\u1ec3 \u0111\u1ebfn bao g\u1ed3m y\u1ebfu t\u1ed1 nh\u00e2n ch\u1ee7ng h\u1ecdc, y\u1ebfu t\u1ed1 di truy\u1ec1n, b\u1ec7nh l\u00fd v\u00e0 thu\u1ed1c c\u00f3 y\u1ebfu t\u1ed1 to\u00e0n th\u00e2n v\u00e0 b\u1ec7nh nh\u00e2n cao tu\u1ed5i. C\u00f9ng t\u00ecm hi\u1ec3u.<\/strong><\/p>\n

1. Y\u1ebfu t\u1ed1 nh\u00e2n ch\u1ee7ng h\u1ecdc<\/h2>\n

Ng\u01b0\u1eddi ta kh\u00f4ng th\u1ea5y tu\u1ed5i v\u00e0 gi\u1edbi c\u00f3 \u1ea3nh h\u01b0\u1edfng nhi\u1ec1u \u0111\u1ebfn k\u1ebft qu\u1ea3 \u0111i\u1ec1u tr\u1ecb n\u1ed9i nha v\u00e0 \u0111i\u1ec1u tr\u1ecb n\u1ed9i nha l\u1ea1i. K\u1ebft qu\u1ea3 c\u1ee7a c\u00e1c nghi\u00ean c\u1ee9u v\u1ec1 t\u1ec9 l\u1ec7 t\u1ed3n t\u1ea1i c\u1ee7a r\u0103ng \u0111\u00e3 \u0111i\u1ec1u tr\u1ecb n\u1ed9i nha c\u00f3 li\u00ean quan \u0111\u1ebfn c\u00e1c y\u1ebfu t\u1ed1 n\u00e0y r\u1ea5t kh\u00e1c nhau.<\/p>\n

2. Y\u1ebfu t\u1ed1 di truy\u1ec1n<\/h2>\n

R\u1ed1i lo\u1ea1n di truy\u1ec1n ho\u1eb7c \u0111a h\u00ecnh di truy\u1ec1n c\u00f3 th\u1ec3 \u1ea3nh h\u01b0\u1edfng \u0111\u1ebfn c\u01a1 ch\u1ebf ph\u00f2ng v\u1ec7 c\u1ee7a k\u00ed ch\u1ee7, ch\u1eb3ng h\u1ea1n nh\u01b0 kh\u1ea3 n\u0103ng mi\u1ec5n d\u1ecbch b\u1ea9m sinh hay thu \u0111\u01b0\u1ee3c, d\u1eabn \u0111\u1ebfn s\u1ef1 nh\u1ea1y c\u1ea3m v\u1edbi b\u1ec7nh l\u00fd ho\u1eb7c s\u1ef1 thay \u0111\u1ed5i \u0111\u00e1p \u1ee9ng v\u1edbi \u0111i\u1ec1u tr\u1ecb. R\u1ed1i lo\u1ea1n di truy\u1ec1n l\u00e0 m\u1ed9t khi\u1ebfm khuy\u1ebft th\u01b0\u1eddng g\u00e2y ra b\u1edfi 1 ho\u1eb7c nhi\u1ec1u b\u1ea5t th\u01b0\u1eddng trong h\u1ec7 gen. \u0110a h\u00ecnh di truy\u1ec1n th\u00ec do m\u1ed9t s\u1ed1 \u0111\u1ed9t bi\u1ebfn \u0111i\u1ec3m nh\u1ea5t \u0111\u1ecbnh trong ki\u00eau gen.
\nC\u00f3 r\u1ea5t \u00edt nghi\u00ean c\u1ee9u v\u1ec1 m\u1ed1i quan h\u1ec7 gi\u1eefa \u0111a h\u00ecnh di truy\u1ec1n v\u00e0 vi\u00eam quanh ch\u00f3p sau \u0111i\u1ec1u tr\u1ecb. 2 \u0111i\u1ec1u ki\u1ec7n di truy\u1ec1n, g\u1ed3m s\u1ef1 v\u1eadn chuy\u1ec3n allele H131 c\u1ee7a gen FcrRIIa v\u00e0 s\u1ef1 k\u1ebft h\u1ee3p c\u1ee7a allele n\u00e0y v\u1edbi allele Na2 c\u1ee7a gen FcrRIIIb, \u0111\u01b0\u1ee3c b\u00e1o c\u00e1o l\u00e0 c\u00f3 li\u00ean quan \u0111\u1ebfn vi\u00eam quanh ch\u00f3p sau \u0111i\u1ec1u tr\u1ecb. Nh\u1eefng c\u00e1 th\u1ec3 c\u00f3 allele hi\u1ebfm (allele 2 ho\u1eb7c T) c\u1ee7a IL-1B \u0111\u01b0\u1ee3c b\u00e1o c\u00e1o \u0111\u1ebfn 7 l\u1ea7n l\u00e0 d\u1ec5 b\u1ecb vi\u00eam quanh ch\u00f3p sau \u0111i\u1ec1u tr\u1ecb h\u01a1n khi so s\u00e1nh v\u1edbi nh\u1eefng c\u00e1 th\u1ec3 \u0111\u1ed3ng h\u1ee3p v\u1edbi allele th\u00f4ng th\u01b0\u1eddng (allele 1 ho\u1eb7c C). C\u00e1c polymorphism \u0111\u01a1n nucleotide (single nucleotide polymorphism \u2013 SNP) c\u1ee7a c\u00e1c gen kh\u00e1c li\u00ean quan \u0111\u1ebfn vi\u00eam, c\u00e1c khung metalloproteinase (MMP) 2 and 3 c\u0169ng cho th\u1ea5y s\u1ef1 nh\u1ea1y c\u1ea3m \u0111\u1ed1i v\u1edbi s\u1ef1 ph\u00e1t tri\u1ec3n t\u1ed5n th\u01b0\u01a1ng quanh ch\u00f3p v\u00e0 \u0111\u00e1p \u1ee9ng l\u00e0nh th\u01b0\u01a1ng.<\/p>\n

3. B\u1ec7nh l\u00fd v\u00e0 c\u00e1c thu\u1ed1c s\u1eed d\u1ee5ng c\u00f3 y\u1ebfu t\u1ed1 to\u00e0n th\u00e2n<\/h2>\n

C\u00e1c nghi\u00ean c\u1ee9u tr\u01b0\u1edbc kia th\u1ea5y r\u1eb1ng b\u1ec7nh lo\u00e3ng x\u01b0\u01a1ng, thi\u1ebfu vitamin C, li\u1ec7u ph\u00e1p steroid v\u00e0 b\u1ec7nh \u0111\u00e1i th\u00e1o \u0111\u01b0\u1eddng c\u00f3 th\u1ec3 l\u00e0m c\u1ea3n tr\u1edf l\u00e0nh th\u01b0\u01a1ng, v\u00e0 do \u0111\u00f3 g\u00e2y \u1ea3nh h\u01b0\u1edfng x\u1ea5u \u0111\u1ebfn k\u1ebft qu\u1ea3 \u0111i\u1ec1u tr\u1ecb n\u1ed9i nha. Trong s\u1ed1 nh\u1eefng b\u1ec7nh l\u00fd k\u1ec3 tr\u00ean, c\u00f3 b\u1eb1ng ch\u1ee9ng khoa h\u1ecdc t\u1ed3n t\u1ea1i \u00edt nh\u1ea5t l\u00e0 ch\u1ee9ng minh li\u1ec7u ph\u00e1p steroid v\u00e0 b\u1ec7nh l\u00fd \u0111\u00e1i th\u00e1o \u0111\u01b0\u1eddng c\u00f3 \u1ea3nh h\u01b0\u1edfng \u0111\u1ebfn k\u1ebft qu\u1ea3 \u0111i\u1ec1u tr\u1ecb n\u1ed9i nha. M\u1ed9t b\u00e0i vi\u1ebft t\u1ed5ng h\u1ee3p g\u1ea7n \u0111\u00e2y kh\u00f4ng t\u00ecm th\u1ea5y \u1ea3nh h\u01b0\u1edfng \u0111\u00e1ng k\u1ec3 n\u00e0o c\u1ee7a s\u1ee9c kh\u1ecfe to\u00e0n th\u00e2n \u0111\u1ebfn k\u1ebft qu\u1ea3 \u0111i\u1ec1u tr\u1ecb n\u1ed9i nha. Tuy nhi\u00ean, nhi\u1ec1u b\u1eb1ng ch\u1ee9ng cho r\u1eb1ng nhi\u1ec1u v\u1ea5n \u0111\u1ec1 li\u00ean quan \u0111\u1ebfn b\u1ec7nh l\u00fd h\u1ec7 th\u1ed1ng c\u00f3 g\u00e2y \u1ea3nh h\u01b0\u1edfng \u0111\u1ebfn k\u1ebft qu\u1ea3 \u0111i\u1ec1u tr\u1ecb.<\/p>\n

B\u1ec7nh \u0111\u00e1i th\u00e1o \u0111\u01b0\u1eddng<\/strong><\/p>\n

\u0110\u00e1i th\u00e1o \u0111\u01b0\u1eddng c\u00f3 r\u1ea5t nhi\u1ec1u bi\u1ebfn ch\u1ee9ng li\u00ean quan \u0111\u1ebfn s\u1ee9c kh\u1ecfe r\u0103ng mi\u1ec7ng. T\u0103ng nh\u1ea1y c\u1ea3m v\u1edbi nhi\u1ec5m tr\u00f9ng, b\u1ec7nh l\u00fd th\u1ea7n kinh, l\u00e0m ch\u1eadm l\u00e0nh th\u01b0\u01a1ng l\u00e0 nh\u1eefng v\u1ea5n \u0111\u1ec1 tr\u00ean b\u1ec7nh nh\u00e2n \u0111\u00e1i th\u00e1o \u0111\u01b0\u1eddng c\u00f3 th\u1ec3 l\u00e0m \u1ea3nh h\u01b0\u1edfng \u0111\u1ebfn k\u1ebft qu\u1ea3 \u0111i\u1ec1u tr\u1ecb.<\/p>\n

H\u1ea7u h\u1ebft c\u00e1c nghi\u00ean c\u1ee9u cho th\u1ea5y \u0111\u00e1i th\u00e1o \u0111\u01b0\u1eddng li\u00ean quan \u0111\u1ebfn s\u1ef1 gia t\u0103ng t\u1ec9 l\u1ec7 vi\u00eam quanh ch\u00f3p. Tr\u00e1i v\u1edbi nh\u1eefng nghi\u00ean c\u1ee9u n\u00e0y, m\u1ed9t nghi\u00ean c\u1ee9u kh\u00e1c kh\u00f4ng t\u00ecm th\u1ea5y m\u1ed1i li\u00ean h\u1ec7 gi\u1eefa b\u1ec7nh l\u00fd \u0111\u00e1i th\u00e1o \u0111\u01b0\u1eddng v\u1edbi vi\u00eam quanh ch\u00f3p \u1edf nh\u1eefng r\u0103ng \u0111\u00e3 \u0111i\u1ec1u tr\u1ecb.<\/p>\n

Fouad cho r\u1eb1ng b\u1ec7nh nh\u00e2n \u0111\u00e1i th\u00e1o \u0111\u01b0\u1eddng c\u00f3 vi\u00eam quanh ch\u00f3p tr\u01b0\u1edbc \u0111i\u1ec1u tr\u1ecb d\u01b0\u1eddng nh\u01b0 \u00edt c\u00f3 kh\u1ea3 n\u0103ng x\u00e1c \u0111\u1ecbnh th\u00e0nh c\u00f4ng kho\u1ea3ng sau 2 n\u0103m ho\u1eb7c l\u00e2u h\u01a1n sau \u0111i\u1ec1u tr\u1ecb. M\u1ed9t nghi\u00ean c\u1ee9u k\u1ebft qu\u1ea3 \u0111i\u1ec1u tr\u1ecb n\u1ed9i nha cho th\u1ea5y b\u1ec7nh nh\u00e2n c\u00f3 ti\u1ec1n s\u1eed \u0111\u00e1i th\u00e1o \u0111\u01b0\u1eddng th\u00ec l\u00e0m gi\u1ea3m \u0111\u00e1ng k\u1ec3 t\u1ec9 l\u1ec7 th\u00e0nh c\u00f4ng. M\u1ed9t nghi\u00ean c\u1ee9u th\u0103m d\u00f2 v\u1ec1 c\u00e1c y\u1ebfu t\u1ed1 \u1ea3nh h\u01b0\u1edfng \u0111\u1ebfn s\u1ef1 t\u1ed3n t\u1ea1i c\u1ee7a r\u0103ng \u0111\u01b0\u1ee3c \u0111i\u1ec1u tr\u1ecb n\u1ed9i nha kh\u00f4ng ph\u1eabu thu\u1eadt cho th\u1ea5y b\u1ec7nh nh\u00e2n \u0111\u00e1i th\u00e1o \u0111\u01b0\u1eddng c\u00f3 t\u1ec9 l\u1ec7 nh\u1ed5 r\u0103ng sau \u0111i\u1ec1u tr\u1ecb n\u1ed9i nha cao h\u01a1n. Nghi\u00ean c\u1ee9u n\u00e0y c\u0169ng ph\u00f9 h\u1ee3p v\u1edbi m\u1ed9t nghi\u00ean c\u1ee9u th\u0103m d\u00f2 kh\u00e1c, cho th\u1ea5y nguy c\u01a1 r\u0103ng b\u1ecb nh\u1ed5 sau \u0111i\u1ec1u tr\u1ecb n\u1ed9i nha c\u00f3 li\u00ean quan nhi\u1ec1u v\u1edbi b\u1ec7nh l\u00fd \u0111\u00e1i th\u00e1o \u0111\u01b0\u1eddng. \u0110i\u1ec1u th\u00fa v\u1ecb n\u00ean l\u01b0u \u00fd l\u00e0 trong nghi\u00ean c\u1ee9u c\u1ee7a Ng, h\u1ea7u h\u1ebft c\u00e1c r\u0103ng m\u1ea5t l\u00e0 do \u0111au dai d\u1eb3ng sau \u0111i\u1ec1u tr\u1ecb, c\u00f3 th\u1ec3 l\u00e0 do b\u1ec7nh l\u00fd \u0111au d\u00e2y th\u1ea7n kinh ch\u1ee9 kh\u00f4ng ph\u1ea3i do ch\u1eadm l\u00e0nh th\u01b0\u01a1ng. Trong nghi\u00ean c\u1ee9u c\u1ee7a Wang, h\u1ea7u h\u1ebft c\u00e1c r\u0103ng b\u1ecb nh\u1ed5 \u0111\u1ec1u li\u00ean quan \u0111\u1ebfn ph\u1ee5c h\u1ed3i ho\u1eb7c n\u1ee9t g\u00e3y r\u0103ng.<\/p>\n

B\u1ec7nh t\u0103ng huy\u1ebft \u00e1p<\/strong><\/p>\n

M\u1ed9t nghi\u00ean c\u1ee9u cho th\u1ea5y t\u1ec9 l\u1ec7 vi\u00eam quanh ch\u00f3p sau \u0111i\u1ec1u tr\u1ecb n\u1ed9i nha kh\u00f4ng c\u00f3 s\u1ef1 kh\u00e1c bi\u1ec7t \u0111\u00e1ng k\u1ec3 n\u00e0o tr\u00ean nh\u1eefng b\u1ec7nh nh\u00e2n cao huy\u1ebft \u00e1p. Tuy nhi\u00ean, c\u00f3 m\u1ed9t v\u00e0i nghi\u00ean c\u1ee9u kh\u00e1c cho th\u1ea5y r\u0103ng nh\u1ed5 sau \u0111i\u1ec1u tr\u1ecb c\u00f3 li\u00ean quan nhi\u1ec1u v\u1edbi cao huy\u1ebft \u00e1p. M\u1eb7c d\u00f9 \u0111\u00e1i th\u00e1o \u0111\u01b0\u1eddng v\u00e0 cao huy\u1ebft \u00e1p c\u00f3 th\u1ec3 c\u00f9ng t\u1ed3n t\u1ea1i, nh\u01b0ng m\u1ed9t nghi\u00ean c\u1ee9u thu \u0111\u01b0\u1ee3c k\u1ebft qu\u1ea3 l\u00e0 \u0111\u00e1i th\u00e1o \u0111\u01b0\u1eddng v\u00e0 cao huy\u1ebft \u00e1p l\u00e0 2 y\u1ebfu t\u1ed1 nguy c\u01a1 \u0111\u1ed9c l\u1eadp nhau khi\u1ebfn cho r\u0103ng b\u1ecb nh\u1ed5 sau 2 n\u0103m \u0111i\u1ec1u tr\u1ecb n\u1ed9i nha kh\u00f4ng ph\u1eabu thu\u1eadt.<\/p>\n

H\u00fat thu\u1ed1c l\u00e1<\/strong><\/p>\n

M\u1ed9t s\u1ed1 nghi\u00ean c\u1ee9u ch\u1ec9 ra r\u1eb1ng t\u1ec9 l\u1ec7 vi\u00eam quanh ch\u00f3p sau \u0111i\u1ec1u tr\u1ecb n\u1ed9i nha cao h\u01a1n \u0111\u00e1ng k\u1ec3 \u1edf nh\u1eefng b\u1ec7nh nh\u00e2n cao huy\u1ebft \u00e1p c\u00f3 h\u00fat thu\u1ed1c l\u00e1 so v\u1edbi b\u1ec7nh nh\u00e2n kh\u00f4ng h\u00fat thu\u1ed1c l\u00e1. M\u1ed9t nghi\u00ean c\u1ee9u kh\u00e1c c\u0169ng b\u00e1o c\u00e1o r\u1eb1ng h\u00fat thu\u1ed1c l\u00e1 g\u00e2y \u1ea3nh h\u01b0\u1edfng l\u1edbn \u0111\u1ebfn b\u1ec7nh l\u00fd v\u00e0 ti\u00ean l\u01b0\u1ee3ng n\u1ed9i nha. Tuy nhi\u00ean, c\u1ea7n nhi\u1ec1u nghi\u00ean c\u1ee9u d\u1ef1a tr\u00ean b\u1eb1ng ch\u1ee9ng n\u1eefa \u0111\u1ec3 kh\u1eb3ng \u0111\u1ecbnh t\u1ea7m \u1ea3nh h\u01b0\u1edfng c\u1ee7a y\u1ebfu t\u1ed1 n\u00e0y l\u00ean k\u1ebft qu\u1ea3 \u0111i\u1ec1u tr\u1ecb.<\/p>\n

H\u1ed9i ch\u1ee9ng suy gi\u1ea3m mi\u1ec5n d\u1ecbch m\u1eafc ph\u1ea3i (HIV)<\/strong><\/p>\n

Virus HIV \u0111\u00e3 \u0111\u01b0\u1ee3c ph\u00e1t hi\u1ec7n trong m\u00f4 t\u1ee7y r\u0103ng v\u00e0 t\u1ed5n th\u01b0\u01a1ng quanh ch\u00f3p tr\u00ean nh\u1eefng b\u1ec7nh nh\u00e2n c\u00f3 HIV (+). Do \u0111\u00f3, vai tr\u00f2 c\u1ee7a n\u00f3 trong sinh b\u1ec7nh h\u1ecdc v\u00e0 s\u1ef1 l\u00e0nh th\u01b0\u01a1ng c\u1ee7a t\u1ed5n th\u01b0\u01a1ng quanh ch\u00f3p \u0111ang l\u00e0 m\u1ed9t m\u1ed1i quan t\u00e2m. Ng\u01b0\u1eddi ta \u0111\u00e3 b\u00e1o c\u00e1o r\u1eb1ng c\u00e1c t\u00ecnh tr\u1ea1ng li\u00ean quan \u0111\u1ebfn suy gi\u1ea3m \u0111\u00e1p \u1ee9ng mi\u1ec5n d\u1ecbch kh\u00f4ng \u0111\u1eb7c hi\u1ec7u l\u00e0m gi\u1ea3m t\u1ec9 l\u1ec7 th\u00e0nh c\u00f4ng c\u1ee7a \u0111i\u1ec1u tr\u1ecb n\u1ed9i nha, nh\u01b0ng h\u1ea7u h\u1ebft c\u00e1c b\u1eb1ng ch\u1ee9ng hi\u1ec7n c\u00f3 th\u00ec kh\u00f4ng \u1ee7ng h\u1ed9 v\u1edbi th\u1ef1c t\u1ebf l\u00e0 t\u1ec9 l\u1ec7 th\u00e0nh c\u00f4ng \u1edf nh\u1eefng b\u1ec7nh nh\u00e2n HIV (+) th\u1ea5p h\u01a1n b\u1ec7nh nh\u00e2n HIV (-). M\u1ed9t nghi\u00ean c\u1ee9u b\u00e1o c\u00e1o r\u1eb1ng \u0111i\u1ec1u tr\u1ecb n\u1ed9i nha \u1edf nh\u1eefng b\u1ec7nh nh\u00e2n HIV (+) kh\u00f4ng li\u00ean quan \u0111\u1ebfn c\u00e1c bi\u1ebfn ch\u1ee9ng ng\u1eafn h\u1ea1n (3 th\u00e1ng). Trong m\u1ed9t nghi\u00ean c\u1ee9u \u0111\u00e1nh gi\u00e1 k\u1ebft qu\u1ea3 \u0111i\u1ec1u tr\u1ecb, c\u00e1c t\u00e1c gi\u1ea3 kh\u00f4ng t\u00ecm th\u1ea5y s\u1ef1 kh\u00e1c bi\u1ec7t n\u00e0o gi\u1eefa k\u1ebft qu\u1ea3 \u0111i\u1ec1u tr\u1ecb n\u1ed9i nha \u1edf nh\u1eefng b\u1ec7nh nh\u00e2n HIV\/AIDS khi so s\u00e1nh v\u1edbi nh\u1eefng b\u1ec7nh nh\u00e2n kh\u00f4ng b\u1ecb b\u1ec7nh. M\u1ed9t nghi\u00ean c\u1ee9u kh\u00e1c b\u00e1o c\u00e1o r\u1eb1ng kh\u00f4ng c\u00f3 s\u1ef1 kh\u00e1c bi\u1ec7t mang \u00fd ngh\u0129a th\u1ed1ng k\u00ea gi\u1eefa 2 nh\u00f3m b\u1ec7nh nh\u00e2n (HIV (+) v\u00e0 HIV (- )) v\u1ec1 m\u1ee9c \u0111\u1ed9 l\u00e0nh th\u01b0\u01a1ng c\u1ee7a m\u00f4 quanh ch\u00f3p sau 1 n\u0103m \u0111i\u1ec1u tr\u1ecb n\u1ed9i nha.<\/p>\n

Li\u1ec7u ph\u00e1p steroid to\u00e0n th\u00e2n<\/strong><\/p>\n

\u1ea2nh h\u01b0\u1edfng ti\u00eau c\u1ef1c c\u1ee7a li\u1ec7u ph\u00e1p steroid to\u00e0n th\u00e2n \u0111\u1ed1i v\u1edbi k\u1ebft qu\u1ea3 \u0111i\u1ec1u tr\u1ecb l\u00e0 do n\u00f3 l\u00e0m ch\u1eadm l\u00e0nh th\u01b0\u01a1ng v\u00e0 l\u00e0m suy gi\u1ea3m h\u1ec7 th\u1ed1ng mi\u1ec5n d\u1ecbch. M\u1ed9t nghi\u00ean c\u1ee9u th\u0103m d\u00f2 v\u1ec1 c\u00e1c y\u1ebfu t\u1ed1 \u1ea3nh h\u01b0\u1edfng \u0111\u1ebfn s\u1ef1 t\u1ed3n t\u1ea1i c\u1ee7a r\u0103ng \u0111\u00e3 \u0111\u01b0\u1ee3c \u0111i\u1ec1u tr\u1ecb n\u1ed9i nha kh\u00f4ng ph\u1eabu thu\u1eadt cho th\u1ea5y nh\u1eefng b\u1ec7nh nh\u00e2n \u0111\u01b0\u1ee3c \u0111i\u1ec1u tr\u1ecb steroid c\u00f3 th\u1ec3 c\u00f3 t\u1ec9 l\u1ec7 ph\u1ea3i nh\u1ed5 r\u0103ng \u0111\u00e3 \u0111i\u1ec1u tr\u1ecb cao h\u01a1n.<\/p>\n

Li\u1ec7u ph\u00e1p bisphosphonate<\/strong><\/p>\n

Bisphosphonate th\u01b0\u1eddng \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng \u0111\u1ec3 ki\u1ec3m so\u00e1t v\u00e0 \u0111i\u1ec1u tr\u1ecb b\u1ec7nh l\u00fd v\u1ec1 x\u01b0\u01a1ng, nh\u01b0 lo\u00e3ng x\u01b0\u01a1ng ho\u1eb7c b\u1ec7nh Paget, \u0111\u1ec3 ng\u0103n ng\u1eeba c\u00e1c bi\u1ebfn ch\u1ee9ng tr\u00ean x\u01b0\u01a1ng v\u00e0 \u0111\u1ec3 \u0111i\u1ec1u tr\u1ecb t\u0103ng canxi m\u00e1u \u00e1c t\u00ednh \u1edf m\u1ed9t s\u1ed1 lo\u1ea1i ung th\u01b0 nh\u1ea5t \u0111\u1ecbnh.<\/p>\n

H\u1ea7u h\u1ebft c\u00e1c hi\u1ec3u bi\u1ebft v\u1ec1 t\u00e1c d\u1ee5ng c\u1ee7a bisphosphonate tr\u00ean k\u1ebft qu\u1ea3 \u0111i\u1ec1u tr\u1ecb n\u1ed9i nha \u0111\u1ec1u \u0111\u01b0\u1ee3c thu th\u1eadp th\u00f4ng qua c\u00e1c b\u00e0i b\u00e1o c\u00e1o l\u00e2m s\u00e0ng. Theo tuy\u00ean b\u1ed1 c\u1ee7a b\u1ed9 n\u1ed9i nha M\u1ef9, b\u1ec7nh nh\u00e2n s\u1eed d\u1ee5ng bisphosphonate IV c\u00f3 nguy c\u01a1 cao h\u01a1n b\u1ec7nh nh\u00e2n s\u1eed d\u1ee5ng bisphosphonate \u0111\u01b0\u1eddng u\u1ed1ng. Trong nh\u1eefng tr\u01b0\u1eddng h\u1ee3p tr\u01b0\u1edbc \u0111\u00e2y, \u0111i\u1ec1u tr\u1ecb n\u1ed9i nha truy\u1ec1n th\u1ed1ng kh\u00f4ng ph\u1eabu thu\u1eadt l\u00e0 bi\u1ec7n ph\u00e1p \u0111i\u1ec1u tr\u1ecb th\u00edch h\u1ee3p trong tr\u01b0\u1eddng h\u1ee3p kh\u00f4ng \u0111\u01b0\u1ee3c nh\u1ed5 r\u0103ng. C\u00e1c b\u00e1o c\u00e1o l\u00e2m s\u00e0ng cho th\u1ea5y \u0111i\u1ec1u tr\u1ecb n\u1ed9i nha truy\u1ec1n th\u1ed1ng c\u0169ng th\u00e0nh c\u00f4ng trong nh\u1eefng tr\u01b0\u1eddng h\u1ee3p t\u01b0\u01a1ng t\u1ef1.<\/p>\n

4. B\u1ec7nh nh\u00e2n cao tu\u1ed5i v\u1edbi y\u1ebfu t\u1ed1 to\u00e0n th\u00e2n<\/h2>\n

Ng\u01b0\u1eddi ta nh\u1eadn th\u1ea5y r\u1eb1ng tu\u1ed5i kh\u00f4ng ph\u1ea3i l\u00e0 y\u1ebfu t\u1ed1 quy\u1ebft \u0111\u1ecbnh th\u00e0nh c\u00f4ng c\u1ee7a vi\u1ec7c \u0111i\u1ec1u tr\u1ecb. Tuy nhi\u00ean, ph\u00e1t hi\u1ec7n n\u00e0y c\u00f3 th\u1ec3 b\u1ecb sai l\u1ec7ch b\u1edfi m\u1ed9t s\u1ed1 l\u01b0\u1ee3ng \u00edt b\u1ec7nh nh\u00e2n l\u1edbn tu\u1ed5i so v\u1edbi b\u1ec7nh nh\u00e2n tr\u1ebb tu\u1ed5i trong nh\u1eefng nghi\u00ean c\u1ee9u \u0111\u00f3. N\u00f3i chung c\u1ea7n ph\u1ea3i hi\u1ec3u v\u00e0 c\u00e2n nh\u1eafc \u0111\u00fang y\u1ebfu t\u1ed1 to\u00e0n th\u00e2n (nh\u01b0 \u0111au v\u00f9ng mi\u1ec7ng \u2013 m\u1eb7t c\u00f3 nguy\u00ean nh\u00e2n t\u1eeb t\u00e1c d\u1ee5ng ph\u1ee5 c\u1ee7a thu\u1ed1c), y\u1ebfu t\u1ed1 t\u1ea1i ch\u1ed7 (nh\u01b0 v\u00f4i h\u00f3a \u1ed1ng t\u1ee7y), y\u1ebfu t\u1ed1 sinh h\u1ecdc v\u00e0 s\u1ef1 kh\u00e1c bi\u1ec7t gi\u1ea3i ph\u1eabu m\u00f4 r\u0103ng gi\u1eefa b\u1ec7nh nh\u00e2n gi\u00e0 v\u00e0 tr\u1ebb. Nh\u1eefng s\u1ef1 kh\u00e1c bi\u1ec7t n\u00e0y, n\u1ebfu kh\u00f4ng \u0111\u01b0\u1ee3c c\u00e2n nh\u1eafc k\u0129, c\u00f3 th\u1ec3 d\u1eabn \u0111\u1ebfn ch\u1ea9n \u0111o\u00e1n sai v\u00e0 \u0111i\u1ec1u tr\u1ecb sai. Tuy nhi\u00ean, nh\u1eefng sai kh\u00e1c n\u00e0y th\u01b0\u1eddng kh\u00f4ng ph\u1ea3i l\u00e0 ch\u1ed1ng ch\u1ec9 \u0111\u1ecbnh \u0111i\u1ec1u tr\u1ecb, v\u00ec khi \u0111\u01b0\u1ee3c th\u1ef1c hi\u1ec7n ch\u00ednh x\u00e1c th\u00ec c\u0169ng v\u1eabn th\u00e0nh c\u00f4ng k\u1ec3 c\u1ea3 l\u00e0 tr\u00ean b\u1ec7nh nh\u00e2n l\u1edbn tu\u1ed5i. \u0110i\u1ec1u quan tr\u1ecdng n\u1eefa c\u0169ng c\u1ea7n ph\u1ea3i hi\u1ec3u l\u00e0 th\u00f4ng th\u01b0\u1eddng m\u00f4 quanh ch\u00f3p s\u1ebd l\u00e0nh th\u01b0\u01a1ng \u1edf ng\u01b0\u1eddi gi\u00e0 c\u0169ng d\u1ec5 d\u00e0ng nh\u01b0 \u1edf ng\u01b0\u1eddi tr\u1ebb. Tuy nhi\u00ean s\u1ef1 l\u00e0nh th\u01b0\u01a1ng c\u00f3 th\u1ec3 m\u1ea5t nhi\u1ec1u th\u1eddi gian h\u01a1n \u1edf ng\u01b0\u1eddi gi\u00e0 so v\u1edbi ng\u01b0\u1eddi tr\u1ebb b\u1edfi v\u00ec c\u00e1c t\u1ebf b\u00e0o g\u1ed1c l\u00e3o h\u00f3a.<\/p>\n

Ngu\u1ed3n: Clinical Guide for Optimal Treatment Outcome – Springer International Publishing Switzerland 2017<\/span><\/em><\/p>\n","protected":false},"excerpt":{"rendered":"

B\u00e0i vi\u1ebft n\u00e0y n\u00f3i v\u1ec1 c\u00e1c y\u1ebfu t\u1ed1 to\u00e0n th\u00e2n v\u00e0 s\u1ef1 \u1ea3nh h\u01b0\u1edfng c\u1ee7a ch\u00fang t\u1edbi nh\u00f3m b\u1ec7nh l\u00fd tu\u1ef7 r\u0103ng. C\u00e1c y\u1ebfu t\u1ed1 to\u00e0n th\u00e2n c\u00f3 th\u1ec3 k\u1ec3 \u0111\u1ebfn bao g\u1ed3m y\u1ebfu t\u1ed1 nh\u00e2n ch\u1ee7ng h\u1ecdc, y\u1ebfu t\u1ed1 di truy\u1ec1n, b\u1ec7nh l\u00fd v\u00e0 thu\u1ed1c c\u00f3 y\u1ebfu t\u1ed1 to\u00e0n th\u00e2n v\u00e0 b\u1ec7nh nh\u00e2n cao […]<\/p>\n","protected":false},"author":21,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[28,33],"tags":[],"yoast_head":"\nY\u1ebfu t\u1ed1 to\u00e0n th\u00e2n \u1ea3nh h\u01b0\u1edfng t\u1edbi b\u1ec7nh l\u00fd tu\u1ef7 r\u0103ng. - Vinmec<\/title>\n<meta name=\"description\" content=\"B\u00e0i vi\u1ebft n\u00e0y n\u00f3i v\u1ec1 c\u00e1c y\u1ebfu t\u1ed1 to\u00e0n th\u00e2n v\u00e0 s\u1ef1 \u1ea3nh h\u01b0\u1edfng c\u1ee7a ch\u00fang t\u1edbi nh\u00f3m b\u1ec7nh l\u00fd tu\u1ef7 r\u0103ng. 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