{"id":28487,"date":"2023-04-29T15:16:43","date_gmt":"2023-04-29T08:16:43","guid":{"rendered":"http:\/\/noithathoaphat.in\/ctv\/?p=28487"},"modified":"2023-04-29T15:16:43","modified_gmt":"2023-04-29T08:16:43","slug":"benh-mau-kho-dong-hemophilia-lich-su-dinh-nghia-sinh-ly-benh","status":"publish","type":"post","link":"http:\/\/noithathoaphat.in\/ctv\/index.php\/2023\/04\/29\/benh-mau-kho-dong-hemophilia-lich-su-dinh-nghia-sinh-ly-benh\/","title":{"rendered":"B\u1ec7nh m\u00e1u kh\u00f3 \u0111\u00f4ng Hemophilia: L\u1ecbch s\u1eed, \u0111\u1ecbnh ngh\u0129a, sinh l\u00fd b\u1ec7nh"},"content":{"rendered":"<p><strong>B\u1ec7nh m\u00e1u kh\u00f3 \u0111\u00f4ng l\u00e0 r\u1ed1i lo\u1ea1n \u0111\u00f4ng m\u00e1u di truy\u1ec1n do thi\u1ebfu h\u1ee5t y\u1ebfu t\u1ed1 VIII, y\u1ebfu t\u1ed1 IX l\u00e0 nh\u1eefng y\u1ebfu t\u1ed1 c\u1ea7n thi\u1ebft cho qu\u00e1 tr\u00ecnh t\u1ea1o c\u1ee5c m\u00e1u \u0111\u00f4ng. Gen s\u1ea3n xu\u1ea5t y\u1ebfu t\u1ed1 VIII\/y\u1ebfu t\u1ed1 IX n\u1eb1m tr\u00ean nhi\u1ec5m s\u1eafc th\u1ec3 gi\u1edbi t\u00ednh, di truy\u1ec1n l\u1eb7n v\u00ec v\u1eady ng\u01b0\u1eddi b\u1ec7nh th\u01b0\u1eddng l\u00e0 nam gi\u1edbi v\u00e0 ng\u01b0\u1eddi ph\u1ee5 n\u1eef l\u00e0 ng\u01b0\u1eddi mang gen b\u1ec7nh. T\u1ea1i Vi\u1ec7t Nam, \u01b0\u1edbc t\u00ednh c\u00f3 kho\u1ea3ng 30.000 ng\u01b0\u1eddi mang gen hemophilia.<\/strong><\/p>\n<figure style=\"width: 500px\" class=\"wp-caption aligncenter\"><img decoding=\"async\" loading=\"lazy\" src=\"https:\/\/vinmec-prod.s3.amazonaws.com\/images\/20190724_102551_887793_mau-kho-dong.max-1800x1800.jpg\" alt=\"M\u00e1u kh\u00f3 \u0111\u00f4ng\" width=\"500\" height=\"320\" \/><figcaption class=\"wp-caption-text\">M\u00e1u kh\u00f3 \u0111\u00f4ng<\/figcaption><\/figure>\n<h2><strong>\u00a01. L\u1ecbch s\u1eed b\u1ec7nh m\u00e1u kh\u00f3 \u0111\u00f4ng (Hemophilia)<\/strong><\/h2>\n<ul>\n<li>T\u1eeb th\u1ebf k\u1ef7 th\u1ee9 hai sau c\u00f4ng nguy\u00ean, ng\u01b0\u1eddi Do Th\u00e1i \u0111\u00e3 m\u00f4 t\u1ea3 tri\u1ec7u ch\u1ee9ng c\u1ee7a b\u1ec7nh trong nh\u1eefng y v\u0103n c\u1ee7a m\u00ecnh v\u00e0 c\u00e1c gi\u00e1o s\u0129 Do Th\u00e1i \u0111\u00e3 mi\u1ec5n vi\u1ec7c c\u1eaft bao quy \u0111\u1ea7u cho nh\u1eefng c\u1eadu b\u00e9 c\u00f3 hai anh trai b\u1ecb ch\u1ebft do ch\u1ea3y m\u00e1u sau th\u1ee7 thu\u1eadt n\u00e0y.<\/li>\n<li>Th\u1ea7y thu\u1ed1c ng\u01b0\u1eddi \u1ea2 R\u1eadp Albucasis (1013-1106) c\u0169ng \u0111\u00e3 m\u00f4 t\u1ea3 v\u1ec1 nh\u1eefng gia \u0111\u00ecnh c\u00f3 nh\u1eefng ng\u01b0\u1eddi \u0111\u00e0n \u00f4ng ch\u1ebft sau nh\u1eefng ch\u1ea5n th\u01b0\u01a1ng r\u1ea5t th\u00f4ng th\u01b0\u1eddng.<\/li>\n<li>N\u0103m 1803, sau khi nghi\u00ean c\u1ee9u ph\u1ea3 h\u1ec7 nh\u1eefng gia \u0111\u00ecnh \u1edf Plymouth (New Hampshire), Cornad Otto, m\u1ed9t b\u00e1c s\u0129 \u1edf Philadelphia \u0111\u00e3 vi\u1ebft lu\u1eadn \u00e1n v\u1edbi ti\u00eau \u0111\u1ec1 &#8220;M\u00f4 t\u1ea3 t\u00ecnh tr\u1ea1ng ch\u1ea3y m\u00e1u t\u1ed3n t\u1ea1i \u1edf m\u1ed9t v\u00e0i gia \u0111\u00ecnh\u201d. \u00d4ng \u0111\u00e1nh gi\u00e1 \u0111\u1eb7c \u0111i\u1ec3m ch\u1ee7 y\u1ebfu c\u1ee7a b\u1ec7nh hemophilia l\u00e0 &#8220;t\u00ecnh tr\u1ea1ng hay b\u1ecb ch\u1ea3y m\u00e1u c\u00f3 xu h\u01b0\u1edbng di truy\u1ec1n \u1edf nh\u1eefng ng\u01b0\u1eddi nam\u201d.<\/li>\n<li>Danh t\u1eeb Hemophilia \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng \u0111\u1ea7u ti\u00ean v\u00e0o n\u0103m 1828<\/li>\n<li>N\u0103m 1952, danh t\u1eeb Hemophilia B ra \u0111\u1eddi, Hemophilia B c\u00f2n g\u1ecdi l\u00e0 &#8220;b\u1ec7nh Christmas\u201d l\u00e0 h\u1ecd c\u1ee7a \u0111\u1ee9a tr\u1ebb \u0111\u1ea7u ti\u00ean \u0111\u01b0\u1ee3c ph\u00e1t hi\u1ec7n v\u1ec1 b\u1ec7nh n\u00e0y.<\/li>\n<li>Hemophilia c\u00f2n \u0111\u01b0\u1ee3c coi nh\u01b0 m\u1ed9t b\u1ec7nh &#8220;ho\u00e0ng gia\u201d b\u1edfi c\u00f3 nhi\u1ec1u gia \u0111\u00ecnh ho\u00e0ng t\u1ed9c Ch\u00e2u \u00c2u m\u1eafc b\u1ec7nh. N\u1eef ho\u00e0ng Victoria \u0111\u01b0\u1ee3c xem l\u00e0 ng\u01b0\u1eddi \u0111\u1ea7u ti\u00ean mang gen hemophilia do \u0111\u1ed9t bi\u1ebfn. Ng\u01b0\u1eddi con th\u1ee9 8 c\u1ee7a b\u00e0 &#8211; Lepold m\u1ea5t n\u0103m 31 tu\u1ed5i do xu\u1ea5t huy\u1ebft n\u00e3o sau khi b\u1ecb ng\u00e3. Hai con g\u00e1i c\u1ee7a N\u1eef ho\u00e0ng Alice v\u00e0 Beatrice l\u00e0 ng\u01b0\u1eddi mang gen Hemophilia. Ch\u00e1u trai Friedrich ch\u1ea3y m\u00e1u \u1edf tu\u1ed5i l\u00ean 2, hai ng\u01b0\u1eddi ch\u00e1u trai kh\u00e1c l\u00e0 Leopold v\u00e0 Maurice, l\u1ea7n l\u01b0\u1ee3t m\u1eafc b\u1ec7nh v\u00e0 qua \u0111\u1eddi \u1edf tu\u1ed5i 32 v\u00e0 23.<\/li>\n<li>M\u1ed9t trong nh\u1eefng tr\u01b0\u1eddng h\u1ee3p m\u1eafc b\u1ec7nh Hemophilia n\u1ed5i ti\u1ebfng nh\u1ea5t l\u00e0 Ho\u00e0ng t\u1eed Alexei Romanov, con trai Sa ho\u00e0ng Nicholas II, ng\u01b0\u1eddi th\u1eeba k\u1ebf ngai v\u00e0ng c\u1ee7a Nga.<\/li>\n<\/ul>\n<p>C\u00e1c th\u1ea7n y Nga th\u1eddi \u0111\u00f3 cho r\u1eb1ng Ho\u00e0ng t\u1eed Alexei b\u1ecb b\u1ec7nh lo\u00e3ng m\u00e1u kinh ni\u00ean do di truy\u1ec1n t\u1eeb b\u00e0 c\u1ed1 l\u00e0 n\u1eef ho\u00e0ng Victoria.<\/p>\n<h2><strong>2. \u0110\u1ecbnh ngh\u0129a<\/strong><\/h2>\n<ul>\n<li>Hemo: Blood, Philia: Love \u00e0 Hemophilia: \u01b0a ch\u1ea3y m\u00e1u<\/li>\n<li>Hemophilia l\u00e0 b\u1ec7nh r\u1ed1i lo\u1ea1n \u0111\u00f4ng m\u00e1u do thi\u1ebfu h\u1ee5t m\u1ed9t trong c\u00e1c y\u1ebfu t\u1ed1 \u0111\u00f4ng m\u00e1u:y\u1ebfu t\u1ed1 VIII,y\u1ebfu t\u1ed1 IX, ho\u1eb7c y\u1ebfu t\u1ed1 XI &#8211; c\u00e1c y\u1ebfu t\u1ed1 sinh thromboplastin n\u1ed9i sinh<\/li>\n<li><strong>Hemophilia A<\/strong> \u2013 Thi\u1ebfu y\u1ebfu t\u1ed1 VIII, di truy\u1ec1n l\u1eb7n tr\u00ean NST X. Chi\u1ebfm g\u1ea7n 85% tr\u01b0\u1eddng h\u1ee3p (t\u1ef7 l\u1ec7 kho\u1ea3ng 1\/500 b\u00e9 trai)<\/li>\n<li><strong>Hemophilia B<\/strong> \u2013 Thi\u1ebfu y\u1ebfu t\u1ed1 IX,c\u00f2n \u0111\u01b0\u1ee3c g\u1ecdi l\u00e0 b\u1ec7nh Christmas, di truy\u1ec1n l\u1eb7n tr\u00ean NST X. Chi\u1ebfm t\u1ec9 l\u1ec7 kho\u1ea3ng 14%.<\/li>\n<li><strong>Hemophilia C<\/strong> \u2013 Thi\u1ebfu y\u1ebfu t\u1ed1 XI, l\u00e0 m\u1ed9t th\u1ec3 nh\u1eb9 c\u1ee7a hemophilia, c\u00f2n \u0111\u01b0\u1ee3c g\u1ecdi l\u00e0 h\u1ed9i ch\u1ee9ng Rosenthal, di truy\u1ec1n l\u1eb7n tr\u00ean NST th\u01b0\u1eddng, ch\u1ee7 y\u1ebfu \u1edf ng\u01b0\u1eddi Do Th\u00e1i. B\u1ec7nh th\u01b0\u1eddng kh\u00f4ng g\u00e2y ch\u1ea3y m\u00e1u t\u1ef1 nhi\u00ean. Xu\u1ea5t huy\u1ebft c\u00f3 th\u1ec3 x\u1ea3y ra sau ch\u1ea5n th\u01b0\u01a1ng ho\u1eb7c ph\u1eabu thu\u1eadt. Ng\u00e0y nay kh\u00f4ng \u0111\u01b0\u1ee3c x\u1ebfp v\u00e0o \u01b0a ch\u1ea3y m\u00e1u v\u00ec kh\u00f4ng c\u00f9ng c\u01a1 ch\u1ebf di truy\u1ec1n nh\u01b0 \u01b0a ch\u1ea3y m\u00e1u A, B<\/li>\n<li><strong>Hemophilia m\u1eafc ph\u1ea3i<\/strong> \u2013 Thi\u1ebfu c\u00e1c y\u1ebfu t\u1ed1 \u0111\u00f4ng m\u00e1u m\u1eafc ph\u1ea3ido t\u1ef1 kh\u00e1ng th\u1ec3 g\u00e2y n\u00ean (th\u01b0\u1eddng l\u00e0 t\u1ef1 kh\u00e1ng th\u1ec3 y\u1ebfu t\u1ed1 VIII). Kh\u00e1ng th\u1ec3 kh\u00e1ng VIII th\u01b0\u1eddng c\u00f3 b\u1ea3n ch\u1ea5t l\u00e0 IgG<\/li>\n<li>Ng\u01b0\u1eddi b\u1ec7nh Hemophilia m\u1eafc b\u1ec7nh t\u1eeb khi sinh ra do nh\u1eadn gen b\u1ec7nh c\u1ee7a ba m\u1eb9. Tuy nhi\u00ean kho\u1ea3ng 30% b\u1ec7nh nh\u00e2n kh\u00f4ng c\u00f3 ti\u1ec1n s\u1eed gia \u0111\u00ecnh. Nh\u1eefng tr\u01b0\u1eddng h\u1ee3p n\u00e0y \u0111\u01b0\u1ee3c cho l\u00e0 do \u0111\u1ed9t bi\u1ebfn gen b\u00ecnh th\u01b0\u1eddng chuy\u1ec3n th\u00e0nh gen b\u1ec7nh v\u00e0 gen b\u1ec7nh n\u00e0y v\u1eabn di truy\u1ec1n cho th\u1ebf h\u1ec7 sau.<\/li>\n<li>B\u1ec7nh kh\u00f4ng th\u1ec3 tr\u1ecb kh\u1ecfi, nh\u01b0ng c\u00f3 th\u1ec3 \u0111i\u1ec1u tr\u1ecb \u0111\u1ec3 gi\u1ea3m thi\u1ec3u tri\u1ec7u ch\u1ee9ng v\u00e0 d\u1ef1 ph\u00f2ng c\u00e1c bi\u1ebfn ch\u1ee9ng s\u1ee9c kh\u1ecfe trong t\u01b0\u01a1ng lai<\/li>\n<li>Hemophilia c\u00f3 t\u1ea7n su\u1ea5t\u00a0 m\u1ed7i n\u0103m \u01b0\u1edbc t\u00ednh c\u1ee7a kho\u1ea3ng 1\/10.000 tr\u1ebb sinh ra. Theo WFH (World Federation of Hemophilia), \u01b0\u1edbc l\u01b0\u1ee3ng s\u1ed1 l\u01b0\u1ee3ng ng\u01b0\u1eddi b\u1ecb hemophilia kho\u1ea3ng 400.000. Hemophilia A, B l\u00e0 b\u1ec7nh di truy\u1ec1n li\u00ean k\u1ebft v\u1edbi NST X n\u00ean x\u1ea3y ra ch\u1ee7 y\u1ebfu \u1edf nam: \u1edf nam gi\u1edbi, trung b\u00ecnh c\u1ee9 10.000 ng\u01b0\u1eddi th\u00ec c\u00f3 m\u1ed9t tr\u01b0\u1eddng h\u1ee3p m\u1eafc b\u1ec7nh, trong khi \u0111\u00f3 \u1edf ph\u1ee5 n\u1eef, c\u1ee9 100.000.000 ng\u01b0\u1eddi th\u00ec c\u00f3 m\u1ed9t tr\u01b0\u1eddng h\u1ee3p m\u1eafc.<\/li>\n<li>\u1ede Vi\u1ec7t Nam \u01b0\u1edbc t\u00ednh c\u00f3 kho\u1ea3ng 6000 ng\u01b0\u1eddi b\u1ec7nh v\u00e0 30.000 ng\u01b0\u1eddi mang gen b\u1ec7nh<\/li>\n<\/ul>\n<h2><strong>3. \u00a0Di truy\u1ec1n h\u1ecdc<\/strong><\/h2>\n<ul>\n<li>Hemophilia l\u00e0 b\u1ec7nh di truy\u1ec1n li\u00ean quan \u0111\u1ebfn gi\u1edbi, b\u1ec7nh h\u1ea7u nh\u01b0 ch\u1ec9 g\u1eb7p \u1edf nam gi\u1edbi. \u0110\u00f3 l\u00e0 do gen b\u1ec7nh n\u1eb1m tr\u00ean nhi\u1ec5m s\u1eafc th\u1ec3 (NST) X.<\/li>\n<li>\u1ede nam gi\u1edbi ch\u1ec9 c\u00f3 m\u1ed9t nhi\u1ec5m s\u1eafc th\u1ec3 X n\u00ean n\u1ebfu nhi\u1ec5m s\u1eafc th\u1ec3 X mang gen b\u1ec7nh VIII hay IX (gen ch\u1ec9 \u0111\u1ea1o t\u1ed5ng h\u1ee3p y\u1ebfu t\u1ed1 VIII hay IX b\u1ecb t\u1ed5n th\u01b0\u01a1ng) th\u00ec l\u01b0\u1ee3ng y\u1ebfu t\u1ed1 VIII ho\u1eb7c IX t\u1ed5ng h\u1ee3p ra kh\u00f4ng \u0111\u1ee7 do \u0111\u00f3 g\u00e2y ra hemophilia.<\/li>\n<li>\u0110\u1ed1i v\u1edbi ph\u1ee5 n\u1eef nh\u1edd c\u00f3 hai nhi\u1ec5m s\u1eafc th\u1ec3 X n\u00ean n\u1ebfu m\u1ed9t nhi\u1ec5m s\u1eafc th\u1ec3 X mang gen b\u1ec7nh th\u00ec c\u00f2n nhi\u1ec5m s\u1eafc th\u1ec3 X th\u1ee9 hai. Gen tr\u00ean nhi\u1ec5m s\u1eafc th\u1ec3 X th\u1ee9 hai n\u00e0y c\u0169ng cho ph\u00e9p t\u1ed5ng h\u1ee3p VIII hay IX, v\u00ec v\u1eady ph\u1ee5 n\u1eef r\u1ea5t \u00edt khi b\u1ecb b\u1ec7nh.<\/li>\n<\/ul>\n<ul>\n<li>Nh\u01b0 v\u1eady n\u1ebfu ng\u01b0\u1eddi ph\u1ee5 n\u1eef c\u00f3 m\u1ed9t nhi\u1ec5m s\u1eafc th\u1ec3 X mang gen b\u1ec7nh (g\u1ecdi l\u00e0 ng\u01b0\u1eddi mang gen) tuy kh\u00f4ng b\u1ecb b\u1ec7nh nh\u01b0ng c\u00f3 th\u1ec3 truy\u1ec1n gen b\u1ec7nh n\u00e0y cho con trai v\u00e0 ng\u01b0\u1eddi con trai n\u00e0y s\u1ebd b\u1ecb b\u1ec7nh, n\u1ebfu truy\u1ec1n gen b\u1ec7nh cho con g\u00e1i th\u00ec con g\u00e1i c\u0169ng s\u1ebd tr\u1edf th\u00e0nh ng\u01b0\u1eddi mang gen b\u1ec7nh.<\/li>\n<li>Ng\u01b0\u1eddi ph\u1ee5 n\u1eef c\u00f3 hai nhi\u1ec5m s\u1eafc th\u1ec3 X n\u00ean nh\u1eefng con trai v\u00e0 con g\u00e1i nh\u1eadn nhi\u1ec5m s\u1eafc th\u1ec3 X b\u00ecnh th\u01b0\u1eddng s\u1ebd kh\u00f4ng b\u1ecb b\u1ec7nh v\u00e0 c\u0169ng kh\u00f4ng mang gen b\u1ec7nh hemophilia.<\/li>\n<li>Kh\u1ea3 n\u0103ng m\u1eafc b\u1ec7nh v\u00e0 mang gen c\u1ee7a con trai v\u00e0 con g\u00e1i khi m\u1eb9 mang gen hemophilia:<\/li>\n<\/ul>\n<p>+ Kh\u1ea3 n\u0103ng sinh con trai kh\u00f4ng m\u1eafc b\u1ec7nh l\u00e0 50%.<\/p>\n<p>+ Kh\u1ea3 n\u0103ng sinh con trai m\u1eafc b\u1ec7nh hemophilia l\u00e0 50%.<\/p>\n<p>+ Kh\u1ea3 n\u0103ng sinh con g\u00e1i b\u00ecnh th\u01b0\u1eddng kh\u00f4ng mang gen b\u1ec7nh l\u00e0 50%<\/p>\n<p>+ Kh\u1ea3 n\u0103ng sinh con g\u00e1i mang gen hemophilia l\u00e0 50%.<\/p>\n<p>&#8211; Tr\u01b0\u1eddng h\u1ee3p b\u1ed1 b\u1ecb hemophilia v\u00e0 m\u1eb9 b\u00ecnh th\u01b0\u1eddng th\u00ec s\u1ebd sinh ra t\u1ea5t c\u1ea3 con g\u00e1i l\u00e0 ng\u01b0\u1eddi mang gen b\u1ec7nh c\u00f2n t\u1ea5t c\u1ea3 con trai kh\u00f4ng b\u1ecb hemophilia.<\/p>\n<ul>\n<li>T\u1ea5t c\u1ea3 con g\u00e1i l\u00e0 ng\u01b0\u1eddi mang gen b\u1ec7nh.<\/li>\n<li>T\u1ea5t c\u1ea3 con trai b\u00ecnh th\u01b0\u1eddng kh\u00f4ng b\u1ecb hemophilia.<\/li>\n<li>Tr\u01b0\u1eddng h\u1ee3p hi\u1ebfm g\u1eb7p: b\u1ed1 b\u1ecb hemophilia, m\u1eb9 l\u00e0 ng\u01b0\u1eddi mang gen b\u1ec7nh. Tr\u01b0\u1eddng h\u1ee3p n\u00e0y c\u00f3 th\u1ec3 sinh ra con g\u00e1i b\u1ecb hemophilia v\u00ec mang 2 nhi\u1ec5m s\u1eafc th\u1ec3 X b\u1ec7nh.<\/li>\n<li>C\u00f3 kho\u1ea3ng m\u1ed9t ph\u1ea7n ba c\u00e1c tr\u01b0\u1eddng h\u1ee3p hemophilia kh\u00f4ng t\u00ecm th\u1ea5y li\u00ean quan v\u1ec1 ti\u1ec1n s\u1eed gia \u0111\u00ecnh. \u0110\u00e2y c\u00f3 th\u1ec3 l\u00e0 do \u0111\u1ed9t bi\u1ebfn trong qu\u00e1 tr\u00ecnh ph\u00e2n chia t\u1ebf b\u00e0o (gi\u1ea3m nhi\u1ec5m) t\u1ea1o ra gen b\u1ec7nh.<\/li>\n<\/ul>\n<h2><strong>4. Sinh l\u00fd b\u1ec7nh.<\/strong><\/h2>\n<h3><strong>4.1. Sinh l\u00fd \u0111\u00f4ng c\u1ea7m m\u00e1u \u00a0<\/strong><\/h3>\n<ul>\n<li>Giai \u0111o\u1ea1n co m\u1ea1ch<\/li>\n<li>Giai \u0111o\u1ea1n ti\u1ec3u c\u1ea7u t\u1ea1o c\u1ee5c m\u00e1u tr\u1eafng<\/li>\n<li>Giai \u0111o\u1ea1n huy\u1ebft t\u01b0\u01a1ng t\u1ea1o c\u1ee5c m\u00e1u \u0111\u1ecf<\/li>\n<li>Giai \u0111o\u1ea1n sinh thromboplastin<\/li>\n<\/ul>\n<p>Giai \u0111o\u1ea1n sinh thrombin -&gt; Giai \u0111o\u1ea1n sinh fibrin<\/p>\n<h3><strong>4.2. Sinh l\u00fd b\u1ec7nh Hemophilia \u00a0<\/strong><\/h3>\n<ul>\n<li>B\u00ecnh th\u01b0\u1eddng, sau khi n\u1ed9i b\u00e0o ho\u1eb7c l\u1edbp d\u01b0\u1edbi n\u1ed9i m\u1ea1c m\u1ea1ch m\u00e1u b\u1ecb t\u1ed5n th\u01b0\u01a1ng. S\u1ef1 co m\u1ea1ch v\u00e0 l\u00e0m h\u1eb9p m\u1ea1ch ngay l\u1eadp t\u1ee9c c\u1ee7a m\u1ea1ch m\u00e1u \u0111\u1ec3 h\u1ea1n ch\u1ebf d\u00f2ng m\u00e1u ch\u1ea3y. Sau \u0111\u00f3 ti\u1ec3u c\u1ea7u tham gia t\u1edbi th\u00e0nh m\u1ea1ch b\u1ecb t\u1ed5n th\u01b0\u01a1ng, v\u00e0 gi\u1ea3i ph\u00f3ng c\u00e1c ch\u1ea5t ho\u1ea1t h\u00f3a v\u00e0 huy \u0111\u1ed9ng th\u00eam nhi\u1ec1u ti\u1ec3u c\u1ea7u \u0111\u1ec3 h\u00ecnh th\u00e0nh n\u00fat ti\u1ec3u c\u1ea7u. S\u1ef1 h\u00ecnh th\u00e0nh n\u00fat ti\u1ec3u c\u1ea7u \u0111\u00f3 \u0111\u01b0\u1ee3c g\u1ecdi l\u00e0 c\u1ea7m m\u00e1u nguy\u00ean ph\u00e1t.<\/li>\n<li>Sau \u0111\u00f3 d\u00f2ng th\u00e1c \u0111\u00f4ng m\u00e1u \u0111\u01b0\u1ee3c k\u00edch ho\u1ea1t. D\u00f2ng th\u00e1c n\u00e0y c\u00f3 \u0111\u1ed9 khu\u1ebfch \u0111\u1ea1i l\u1edbn v\u00e0 di\u1ec5n ra ch\u1ec9 trong m\u1ed9t v\u00e0i ph\u00fat t\u1eeb khi t\u1ed5n th\u01b0\u01a1ng \u0111\u1ebfn khi h\u00ecnh th\u00e0nh c\u1ee5c m\u00e1u \u0111\u00f4ng.<\/li>\n<li>B\u01b0\u1edbc cu\u1ed1i c\u00f9ng l\u00e0 s\u1ef1 ho\u1ea1t h\u00f3a c\u1ee7a protein fibrinogen (y\u1ebfu t\u1ed1 I) h\u00ecnh th\u00e0nh fibrin, n\u00f3 s\u1ebd l\u1eafng \u0111\u1ecdng v\u00e0 g\u1eafn k\u1ebft v\u1edbi nhau h\u00ecnh th\u00e0nh l\u01b0\u1edbi xung quanh c\u00e1c ti\u1ec3u c\u1ea7u.C\u00e1c b\u01b0\u1edbc tr\u00ean \u0111\u00e3 gia c\u1ed1 n\u00fat ti\u1ec3u c\u1ea7u b\u1edfi fibrin v\u00e0 \u0111\u01b0\u1ee3c g\u1ecdi l\u00e0 qu\u00e1 tr\u00ecnh \u0111\u00f4ng m\u00e1u th\u1ee9 ph\u00e1t v\u00e0 k\u1ebft qu\u1ea3 l\u00e0 m\u1ed9t c\u1ee5c m\u00e1u \u0111\u00f4ng v\u1eefng ch\u1eafc n\u1eb1m t\u1ea1i t\u1ed5n th\u01b0\u01a1ng.<\/li>\n<li>Trong Hemophilia c\u00f3 s\u1ef1 gi\u1ea3m s\u1ed1 l\u01b0\u1ee3ng ho\u1eb7c gi\u1ea3m ch\u1ee9c n\u0103ng c\u1ee7a m\u1ed9t ho\u1eb7c nhi\u1ec1u y\u1ebfu t\u1ed1.<\/li>\n<\/ul>\n<p><strong>Ngu\u1ed3n tham kh\u1ea3o:<\/strong><\/p>\n<ul>\n<li><a href=\"https:\/\/www.vinmec.com\/vi\/tin-tuc\/thong-tin-suc-khoe\/benh-mau-kho-dong-co-nguy-hiem\/\">B\u1ec7nh m\u00e1u kh\u00f3 \u0111\u00f4ng<\/a> c\u00f3 nguy hi\u1ec3m &#8211; Vinmec.com<\/li>\n<\/ul>\n","protected":false},"excerpt":{"rendered":"<p>B\u1ec7nh m\u00e1u kh\u00f3 \u0111\u00f4ng l\u00e0 r\u1ed1i lo\u1ea1n \u0111\u00f4ng m\u00e1u di truy\u1ec1n do thi\u1ebfu h\u1ee5t y\u1ebfu t\u1ed1 VIII, y\u1ebfu t\u1ed1 IX l\u00e0 nh\u1eefng y\u1ebfu t\u1ed1 c\u1ea7n thi\u1ebft cho qu\u00e1 tr\u00ecnh t\u1ea1o c\u1ee5c m\u00e1u \u0111\u00f4ng. Gen s\u1ea3n xu\u1ea5t y\u1ebfu t\u1ed1 VIII\/y\u1ebfu t\u1ed1 IX n\u1eb1m tr\u00ean nhi\u1ec5m s\u1eafc th\u1ec3 gi\u1edbi t\u00ednh, di truy\u1ec1n l\u1eb7n v\u00ec v\u1eady ng\u01b0\u1eddi b\u1ec7nh [&hellip;]<\/p>\n","protected":false},"author":6,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[15,33],"tags":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v20.4 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>B\u1ec7nh m\u00e1u kh\u00f3 \u0111\u00f4ng Hemophilia: L\u1ecbch s\u1eed, \u0111\u1ecbnh ngh\u0129a, sinh l\u00fd b\u1ec7nh<\/title>\n<meta name=\"description\" content=\"B\u1ec7nh m\u00e1u kh\u00f3 \u0111\u00f4ng l\u00e0 r\u1ed1i lo\u1ea1n \u0111\u00f4ng m\u00e1u di truy\u1ec1n do thi\u1ebfu h\u1ee5t y\u1ebfu t\u1ed1 VIII, y\u1ebfu t\u1ed1 IX l\u00e0 nh\u1eefng y\u1ebfu t\u1ed1 c\u1ea7n thi\u1ebft cho qu\u00e1 tr\u00ecnh t\u1ea1o c\u1ee5c\" \/>\n<meta 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