{"id":27609,"date":"2023-05-06T11:49:16","date_gmt":"2023-05-06T04:49:16","guid":{"rendered":"http:\/\/noithathoaphat.in\/ctv\/?p=27609"},"modified":"2023-05-06T11:49:16","modified_gmt":"2023-05-06T04:49:16","slug":"7-tuong-tac-pho-bien-khi-su-dung-paxlovid-can-biet","status":"publish","type":"post","link":"http:\/\/noithathoaphat.in\/ctv\/index.php\/2023\/05\/06\/7-tuong-tac-pho-bien-khi-su-dung-paxlovid-can-biet\/","title":{"rendered":"7 t\u01b0\u01a1ng t\u00e1c ph\u1ed5 bi\u1ebfn khi s\u1eed d\u1ee5ng Paxlovid c\u1ea7n bi\u1ebft"},"content":{"rendered":"

Paxlovid l\u00e0 m\u1ed9t lo\u1ea1i thu\u1ed1c m\u1edbi \u0111\u01b0\u1ee3c FDA (C\u1ee5c qu\u1ea3n l\u00fd th\u1ef1c ph\u1ea9m v\u00e0 d\u01b0\u1ee3c ph\u1ea9m Hoa K\u1ef3) ph\u00ea duy\u1ec7t \u0111\u1ec3 \u0111i\u1ec1u tr\u1ecb COVID-19. Tuy nhi\u00ean, nh\u01b0 v\u1edbi b\u1ea5t k\u1ef3 lo\u1ea1i thu\u1ed1c n\u00e0o kh\u00e1c, vi\u1ec7c s\u1eed d\u1ee5ng Paxlovid c\u0169ng c\u00f3 th\u1ec3 g\u00e2y t\u01b0\u01a1ng t\u00e1c thu\u1ed1c v\u00e0 \u1ea3nh h\u01b0\u1edfng \u0111\u1ebfn s\u1ee9c kh\u1ecfe c\u1ee7a b\u1ec7nh nh\u00e2n. Trong b\u00e0i vi\u1ebft n\u00e0y, ch\u00fang ta s\u1ebd t\u00ecm hi\u1ec3u v\u1ec1 7 t\u01b0\u01a1ng t\u00e1c ph\u1ed5 bi\u1ebfn khi s\u1eed d\u1ee5ng Paxlovid c\u1ea7n \u0111\u01b0\u1ee3c bi\u1ebft \u0111\u1ec3 \u0111\u1ea3m b\u1ea3o an to\u00e0n v\u00e0 hi\u1ec7u qu\u1ea3 trong qu\u00e1 tr\u00ecnh \u0111i\u1ec1u tr\u1ecb COVID-19. Vi\u1ec7c \u0111\u1ecdc v\u00e0 hi\u1ec3u r\u00f5 v\u1ec1 c\u00e1c t\u01b0\u01a1ng t\u00e1c n\u00e0y s\u1ebd gi\u00fap b\u1ec7nh nh\u00e2n v\u00e0 c\u00e1c chuy\u00ean gia y t\u1ebf c\u00f3 th\u1ec3 \u0111i\u1ec1u ch\u1ec9nh li\u1ec1u l\u01b0\u1ee3ng ho\u1eb7c thay \u0111\u1ed5i thu\u1ed1c kh\u00e1c thay th\u1ebf \u0111\u1ec3 tr\u00e1nh t\u01b0\u01a1ng t\u00e1c thu\u1ed1c kh\u00f4ng mong mu\u1ed1n.<\/strong><\/p>\n

1.Gi\u1edbi thi\u1ec7u chung v\u1ec1 Paxlovid\u00a0<\/strong><\/h2>\n

K\u1ec3 t\u1eeb th\u1ebf k\u1ef7 19, m\u1ed9t trong nh\u1eefng m\u1ed1i \u0111e d\u1ecda l\u1edbn \u0111\u1ed1i v\u1edbi s\u1ee9c kh\u1ecfe v\u00e0 an to\u00e0n c\u1ed9ng \u0111\u1ed3ng l\u00e0 s\u1ef1 l\u00e2y lan c\u1ee7a \u0111\u1ea1i d\u1ecbch Covid 19 do virus Corona g\u00e2y ra h\u1ed9i ch\u1ee9ng h\u00f4 h\u1ea5p c\u1ea5p t\u00ednh (SARS-CoV-2). Cho \u0111\u1ebfn cu\u1ed1i n\u0103m 2021, h\u01a1n 269 tri\u1ec7u ca m\u1eafc v\u00e0 5,3 tri\u1ec7u ca t\u1eed vong \u0111\u00e3 \u0111\u01b0\u1ee3c ch\u1ee9ng minh, t\u1ea1o n\u00ean \u0111\u1ea1i d\u1ecbch COVID-19. Paxlovid l\u00e0 m\u1ed9t lo\u1ea1i thu\u1ed1c m\u1edbi \u0111\u01b0\u1ee3c ph\u00e1t tri\u1ec3n \u0111\u1ec3 \u0111i\u1ec1u tr\u1ecb COVID-19. \u0110\u00e2y l\u00e0 s\u1ef1 k\u1ebft h\u1ee3p c\u1ee7a hai th\u00e0nh ph\u1ea7n ch\u00ednh l\u00e0 Nirmatrelvir v\u00e0 Ritonavir, \u0111\u01b0\u1ee3c s\u1ea3n xu\u1ea5t b\u1edfi h\u00e3ng d\u01b0\u1ee3c ph\u1ea9m Pfizer. Paxlovid<\/a> \u0111\u01b0\u1ee3c FDA (C\u1ee5c qu\u1ea3n l\u00fd Th\u1ef1c ph\u1ea9m v\u00e0 D\u01b0\u1ee3c ph\u1ea9m Hoa K\u1ef3) c\u1ea5p ph\u00e9p s\u1eed d\u1ee5ng kh\u1ea9n c\u1ea5p v\u00e0o th\u00e1ng 12\/2021 v\u00e0 \u0111\u00e3 \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng r\u1ed9ng r\u00e3i trong c\u00e1c ch\u01b0\u01a1ng tr\u00ecnh \u0111i\u1ec1u tr\u1ecb COVID-19 tr\u00ean to\u00e0n c\u1ea7u. Trong \u0111\u00f3, Nirmatrelvir c\u00f3 vai tr\u00f2 quan tr\u1ecdng trong vi\u1ec7c ng\u0103n ch\u1eb7n ho\u1ea1t ho\u1ea1t \u0111\u1ed9ng enzyme c\u1ea7n cho s\u1ef1 sao ch\u00e9p c\u1ee7a virus v\u00e0 t\u00e1c \u0111\u1ed9ng nh\u01b0 m\u1ed9t ch\u1ea5t \u1ee9c ch\u1ebf c\u1ed9ng h\u00f3a tr\u1ecb li\u00ean k\u1ebft tr\u1ef1c ti\u1ebfp v\u1edbi Cys145. C\u01a1 ch\u1ebf ho\u1ea1t \u0111\u1ed9ng c\u1ee7a Paxlovid l\u00e0 gi\u1ea3m s\u1ef1 ph\u00e1t tri\u1ec3n c\u1ee7a virus SARS-CoV-2 b\u1eb1ng c\u00e1ch \u1ee9c ch\u1ebf m\u1ed9t enzyme quan tr\u1ecdng c\u1ee7a virus g\u1ecdi l\u00e0 protease. Protease l\u00e0 m\u1ed9t enzyme c\u1ea7n thi\u1ebft \u0111\u1ec3 virus SARS-CoV-2 ph\u00e1t tri\u1ec3n v\u00e0 nh\u00e2n \u0111\u00f4i trong c\u01a1 th\u1ec3 con ng\u01b0\u1eddi. B\u1eb1ng c\u00e1ch \u1ee9c ch\u1ebf enzyme n\u00e0y, Paxlovid c\u00f3 th\u1ec3 gi\u1ea3m s\u1ef1 l\u00e2y lan c\u1ee7a virus c\u0169ng nh\u01b0 t\u0103ng kh\u1ea3 n\u0103ng ch\u1ed1ng l\u1ea1i virus. Paxlovid th\u01b0\u1eddng \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng trong c\u00e1c tr\u01b0\u1eddng h\u1ee3p b\u1ec7nh nh\u00e2n COVID-19 d\u01b0\u01a1ng t\u00ednh v\u00e0 c\u00f3 nguy c\u01a1 n\u1eb7ng, bao g\u1ed3m c\u1ea3 c\u00e1c b\u1ec7nh nh\u00e2n kh\u00f4ng \u0111\u01b0\u1ee3c ti\u00eam ch\u1ee7ng v\u1eafc xin ho\u1eb7c kh\u00f4ng c\u00f3 kh\u00e1ng th\u1ec3 \u0111\u1ee7 m\u1ea1nh \u0111\u1ec3 ch\u1ed1ng l\u1ea1i virus. Thu\u1ed1c \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng k\u1ebft h\u1ee3p v\u1edbi m\u1ed9t li\u1ec1u thu\u1ed1c kh\u00e1c c\u00f3 t\u00ean l\u00e0 ritonavir, \u0111\u1ec3 t\u0103ng c\u01b0\u1eddng hi\u1ec7u qu\u1ea3 c\u1ee7a n\u00f3.<\/span><\/p>\n

\"Paxlovid\"
Paxlovid<\/figcaption><\/figure>\n

Tuy nhi\u00ean, Paxlovid c\u0169ng c\u00f3 m\u1ed9t s\u1ed1 t\u00e1c d\u1ee5ng ph\u1ee5 nh\u1ea5t \u0111\u1ecbnh, bao g\u1ed3m \u0111au \u0111\u1ea7u, bu\u1ed3n n\u00f4n, ti\u00eau ch\u1ea3y, v\u00e0 t\u0103ng enzyme gan. N\u00ean s\u1eed d\u1ee5ng thu\u1ed1c theo ch\u1ec9 \u0111\u1ecbnh c\u1ee7a b\u00e1c s\u0129 v\u00e0 th\u01b0\u1eddng \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng trong m\u00f4i tr\u01b0\u1eddng y t\u1ebf.<\/span><\/p>\n

\u0110\u00e2y l\u00e0 m\u1ed9t lo\u1ea1i thu\u1ed1c m\u1edbi hi\u1ec7u qu\u1ea3 trong vi\u1ec7c \u0111i\u1ec1u tr\u1ecb COVID-19 v\u00e0 \u0111\u00e3 \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng r\u1ed9ng r\u00e3i tr\u00ean to\u00e0n c\u1ea7u. Tuy nhi\u00ean, b\u1ec7nh nh\u00e2n c\u1ea7n ph\u1ea3i tu\u00e2n th\u1ee7 c\u00e1c ch\u1ec9 \u0111\u1ecbnh c\u1ee7a b\u00e1c s\u0129 v\u00e0 theo d\u00f5i t\u00e1c d\u1ee5ng ph\u1ee5 c\u1ee7a thu\u1ed1c \u0111\u1ec3 \u0111\u1ea3m b\u1ea3o an to\u00e0n cho s\u1ee9c kh\u1ecfe v\u00e0 hi\u1ec7u qu\u1ea3 c\u1ee7a vi\u1ec7c \u0111i\u1ec1u tr\u1ecb.<\/span><\/p>\n

2.C\u00e1c t\u01b0\u01a1ng t\u00e1c thu\u1ed1c x\u1ea3y ra khi s\u1eed d\u1ee5ng Paxlovid<\/strong><\/h2>\n

Hi\u1ec7u qu\u1ea3 c\u1ee7a Paxlovid \u0111\u00e3 \u0111\u01b0\u1ee3c ch\u1ee9ng minh nh\u01b0ng v\u1eabn c\u00f2n tr\u1edf ng\u1ea1i v\u1ec1 c\u00e1c t\u00e1c d\u1ee5ng ph\u1ee5 kh\u00f4ng mong mu\u1ed1n do Paxlovid t\u01b0\u01a1ng t\u00e1c v\u1edbi nhi\u1ec1u lo\u1ea1i thu\u1ed1c. Paxlovid c\u1ea3n tr\u1edf m\u1ed9t s\u1ed1 enzym (protein) ch\u1ecbu tr\u00e1ch nhi\u1ec7m ph\u00e2n h\u1ee7y thu\u1ed1c. \u0110i\u1ec1u n\u00e0y l\u00e0m cho thu\u1ed1c l\u01b0u l\u1ea1i trong c\u01a1 th\u1ec3 do \u0111\u00f3 c\u00f3 th\u1ec3 l\u00e0m tr\u1ea7m tr\u1ecdng th\u00eam c\u00e1c t\u00e1c d\u1ee5ng ph\u1ee5<\/span><\/p>\n

2.1 T\u01b0\u01a1ng t\u00e1c thu\u1ed1c gi\u1eefa Paxlovid v\u00e0 nh\u00f3m thu\u1ed1c Statin<\/span><\/h3>\n

Statin l\u00e0 lo\u1ea1i thu\u1ed1c ph\u1ed5 bi\u1ebfn gi\u00fap ki\u1ec3m so\u00e1t l\u01b0\u1ee3ng Cholesterol trong m\u00e1u, trong \u0111\u00f3 Atorvastatin th\u01b0\u1eddng \u0111\u01b0\u1ee3c k\u00ea \u0111\u01a1n trong \u0111i\u1ec1u tr\u1ecb. Atorvastatin l\u00e0 m\u1ed9t lo\u1ea1i thu\u1ed1c ch\u1ee7 v\u1eadn c\u1ee7a enzyme HMG-CoA reductase v\u1edbi t\u00e1c \u0111\u1ed9ng l\u00e0m gi\u1ea3m Cholesterol trong m\u00e1u. Th\u00e0nh ph\u1ea7n Ritonavir l\u00e0 ch\u1ea5t \u1ee9c ch\u1ebf enzyme CYP3A5, m\u1ed9t enzyme quan tr\u1ecdng. rong qu\u00e1 tr\u00ecnh chuy\u1ec3n h\u00f3a thu\u1ed1c trong c\u01a1 th\u1ec3. N\u1ebfu Paxlovid \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng \u0111\u1ed3ng th\u1eddi v\u1edbi Atorvastatin, n\u00f3 c\u00f3 th\u1ec3 l\u00e0m t\u0103ng n\u1ed3ng \u0111\u1ed9 c\u1ee7a Atorvastatin trong c\u01a1 th\u1ec3, g\u00e2y ra t\u00e1c d\u1ee5ng ph\u1ee5 kh\u00f4ng mong mu\u1ed1n nh\u01b0 \u0111au \u0111\u1ea7u, bu\u1ed3n n\u00f4n, \u0111au b\u1ee5ng, v\u00e0 \u0111\u1eb7c bi\u1ec7t l\u00e0 t\u0103ng nguy c\u01a1 g\u00e2y ra c\u00e1c v\u1ea5n \u0111\u1ec1 li\u00ean quan \u0111\u1ebfn gan. N\u1ebfu b\u1eaft bu\u1ed9c ph\u1ea3i s\u1eed d\u1ee5ng c\u1ea3 hai thu\u1ed1c trong \u0111i\u1ec1u tr\u1ecb m\u00e0 kh\u00f4ng thay th\u1ebf b\u1eb1ng li\u1ec7u ph\u00e1p n\u00e0o kh\u00e1c th\u00ec n\u00ean ng\u1eebng d\u00f9ng nh\u00f3m thu\u1ed1c Statin kho\u1ea3ng 12 gi\u1edd tr\u01b0\u1edbc khi s\u1eed d\u1ee5ng li\u1ec1u \u0111\u1ea7u ti\u00ean Paxlovid. V\u00ec v\u1eady, c\u1ea7n th\u1eadn tr\u1ecdng v\u00e0 n\u00ean tham kh\u1ea3o \u00fd ki\u1ebfn t\u1eeb b\u00e1c s\u0129 \u0111\u1ec3 \u0111\u1ea3m b\u1ea3o an to\u00e0n v\u00e0 hi\u1ec7u qu\u1ea3 trong \u0111i\u1ec1u tr\u1ecb\u00a0<\/span><\/p>\n

2.2 T\u01b0\u01a1ng t\u00e1c thu\u1ed1c gi\u1eefa Paxlovid v\u00e0 nh\u00f3m thu\u1ed1c tim m\u1ea1ch<\/span><\/h3>\n

Trong nh\u00f3m thu\u1ed1c \u0111i\u1ec1u tr\u1ecb c\u00e1c v\u1ea5n \u0111\u1ec1 tim m\u1ea1ch v\u00e0 huy\u1ebft \u00e1p, c\u00e1c nh\u00f3m thu\u1ed1c \u1ee9c ch\u1ebf men chuy\u1ec3n Angiotensin (ACE), nh\u00f3m thu\u1ed1c \u1ee9c ch\u1ebf th\u1ee5 th\u1ec3 Angiotensin II (ARB) v\u00e0 nh\u00f3m thu\u1ed1c ch\u1eb9n Beta \u0111\u01b0\u1ee3c ch\u1ee9ng minh kh\u00f4ng c\u00f3 x\u1ea3y ra t\u01b0\u01a1ng t\u00e1c v\u1edbi Paxlovid. M\u1eb7c kh\u00e1c, nh\u00f3m thu\u1ed1c ch\u1ed1ng r\u1ed1i lo\u1ea1n nh\u1ecbp tim nh\u01b0 Digoxin \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng trong \u0111i\u1ec1u tr\u1ecb suy tim v\u00e0 nh\u1ecbp tim b\u1ea5t th\u01b0\u1eddng \u0111\u01b0\u1ee3c khuy\u1ebfn c\u00e1o kh\u00f4ng d\u00f9ng \u0111\u1ed3ng th\u1eddi v\u1edbi Paxlovid. C\u1ea3 hai thu\u1ed1c \u0111\u1ec1u c\u00f9ng \u0111\u01b0\u1ee3c chuy\u1ec3n h\u00f3a qua gan b\u1edfi enzyme CYP3A4 do \u0111\u00f3 s\u1ebd x\u1ea3y ra s\u1ef1 c\u1ea1nh tranh trong qu\u00e1 tr\u00ecnh chuy\u1ec3n h\u00f3a thu\u1ed1c, t\u1eeb \u0111\u00f3 l\u00e0m t\u0103ng n\u1ed3ng \u0111\u1ed9 c\u1ee7a Digoxin trong c\u01a1 th\u1ec3 v\u00e0 g\u00e2y ra t\u00e1c d\u1ee5ng ph\u1ee5 kh\u00f4ng mong mu\u1ed1n, nh\u01b0 r\u1ed1i lo\u1ea1n nh\u1ecbp tim, t\u0103ng huy\u1ebft \u00e1p, ho\u1eb7c gi\u1ea3m ch\u1ee9c n\u0103ng th\u1eadn. M\u1ed9t s\u1ed1 thu\u1ed1c tim m\u1ea1ch kh\u00e1c c\u0169ng c\u00f3 kh\u1ea3 n\u0103ng g\u00e2y ra c\u00e1c t\u00e1c d\u1ee5ng ph\u1ee5 khi s\u1eed d\u1ee5ng chung v\u1edbi Paxlovid nh\u01b0 Amiodarone, Ivabradine, Quinidin, Ranolazine,…<\/span><\/p>\n

M\u1ed9t s\u1ed1 lo\u1ea1i thu\u1ed1c ch\u1ed1ng \u0111\u00f4ng m\u00e1u nh\u01b0 Warfarin, Rivaroxaban, Apixaban v\u00e0 Dabigatran \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng \u0111\u1ec3 gi\u1ea3m nguy c\u01a1 \u0111\u1ed9t qu\u1ef5 v\u00e0 \u0111au tim, do \u0111\u00f3 l\u00e0 r\u1ea5t quan tr\u1ecdng trong \u0111i\u1ec1u tr\u1ecb b\u1ec7nh tim m\u1ea1ch. N\u1ebfu s\u1eed d\u1ee5ng \u0111\u1ed3ng th\u1eddi Paxlovid v\u00e0 c\u00e1c thu\u1ed1c ch\u1ed1ng \u0111\u00f4ng m\u00e1u n\u00e0y l\u00e0m t\u0103ng nguy c\u01a1 ch\u1ea3y ch\u1ea3y m\u00e1u ho\u1eb7c g\u00e2y ra t\u00e1c d\u1ee5ng ph\u1ee5 kh\u00e1c.<\/span><\/p>\n

C\u00e1c thu\u1ed1c ch\u1ed1ng huy\u1ebft \u00e1p \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng \u0111\u1ec3 \u0111i\u1ec1u tr\u1ecb cao huy\u1ebft \u00e1p, gi\u1ea3m nguy c\u01a1 \u0111\u1ed9t qu\u1ef5, b\u1ec7nh tim v\u00e0 c\u00e1c v\u1ea5n \u0111\u1ec1 v\u1ec1 tu\u1ea7n ho\u00e0n m\u00e1u. Paxlovid \u0111\u01b0\u1ee3c chuy\u1ec3n h\u00f3a b\u1edfi enzyme CYP3A4 trong gan v\u00e0 c\u00f3 th\u1ec3 \u1ea3nh h\u01b0\u1edfng \u0111\u1ebfn ho\u1ea1t \u0111\u1ed9ng c\u1ee7a c\u00e1c enzyme n\u00e0y. M\u1ed9t s\u1ed1 lo\u1ea1i thu\u1ed1c ch\u1ed1ng huy\u1ebft \u00e1p nh\u01b0 Amlodipine, Losartan, Lisinopril v\u00e0 Enalapril c\u0169ng \u0111\u01b0\u1ee3c chuy\u1ec3n h\u00f3a b\u1edfi c\u00f9ng m\u1ed9t enzyme. Vi\u1ec7c s\u1eed d\u1ee5ng \u0111\u1ed3ng th\u1eddi Paxlovid v\u00e0 c\u00e1c thu\u1ed1c ch\u1ed1ng huy\u1ebft \u00e1p n\u00e0y c\u00f3 th\u1ec3 l\u00e0m t\u0103ng n\u1ed3ng \u0111\u1ed9 c\u1ee7a Paxlovid trong c\u01a1 th\u1ec3 v\u00e0 l\u00e0m gi\u1ea3m t\u00e1c d\u1ee5ng c\u1ee7a c\u00e1c thu\u1ed1c ch\u1ed1ng huy\u1ebft \u00e1p, g\u00e2y ra t\u0103ng huy\u1ebft \u00e1p v\u00e0 c\u00e1c v\u1ea5n \u0111\u1ec1 kh\u00e1c v\u1ec1 s\u1ee9c kh\u1ecfe.<\/span><\/p>\n

2.3 T\u01b0\u01a1ng t\u00e1c thu\u1ed1c gi\u1eefa Paxlovid v\u00e0 m\u1ed9t s\u1ed1 lo\u1ea1i thu\u1ed1c \u0111i\u1ec1u tr\u1ecb s\u1ee9c kh\u1ecfe t\u00e2m th\u1ea7n<\/span><\/h3>\n

M\u1ed9t s\u1ed1 lo\u1ea1i thu\u1ed1c \u0111i\u1ec1u tr\u1ecb ch\u1ee9ng lo \u00e2u v\u00e0 tr\u1ea7m c\u1ea3m \u0111\u01b0\u1ee3c bi\u1ebft l\u00e0 c\u00f3 t\u01b0\u01a1ng t\u00e1c v\u1edbi Paxlovid. Trong \u0111\u00f3, Bupropion v\u00e0 Trazodone l\u00e0 hai lo\u1ea1i thu\u1ed1c ch\u1ed1ng tr\u1ea7m c\u1ea3m c\u1ea7n l\u01b0u \u00fd. C\u1ee5 th\u1ec3, Paxlovid c\u00f3 th\u1ec3 l\u00e0m gi\u1ea3m n\u1ed3ng \u0111\u1ed9 Bupropion, c\u00f3 kh\u1ea3 n\u0103ng l\u00e0m cho n\u00f3 k\u00e9m hi\u1ec7u qu\u1ea3 h\u01a1n nh\u01b0ng l\u1ea1i l\u00e0m t\u0103ng n\u1ed3ng \u0111\u1ed9 Trazodone d\u1eabn \u0111\u1ebfn \u0111\u1ed9c t\u00ednh v\u00e0 c\u00e1c t\u00e1c d\u1ee5ng ph\u1ee5. Nh\u00f3m thu\u1ed1c ch\u1ed1ng lo\u1ea1n th\u1ea7n nh\u01b0 Quetiapine khi d\u00f9ng \u0111\u1ed3ng th\u1eddi v\u1edbi Paxlovid c\u0169ng l\u00e0m t\u0103ng n\u1ed3ng \u0111\u1ed9 Quetiapine trong m\u00e1u khi\u1ebfn c\u00e1c t\u00e1c d\u1ee5ng ph\u1ee5 d\u1ec5 x\u1ea3y ra h\u01a1n. Ngo\u00e0i ra, Paxlovid c\u0169ng c\u00f3 th\u1ec3 g\u00e2y ph\u1ea3n \u1ee9ng nghi\u00eam tr\u1ecdng v\u1edbi Clozapine, Lurasidone v\u00e0 Primozide<\/span><\/p>\n

2.4 T\u01b0\u01a1ng t\u00e1c thu\u1ed1c gi\u1eefa Paxlovid v\u00e0 thu\u1ed1c ch\u1ed1ng \u0111\u1ed9ng kinh<\/span><\/h3>\n

C\u00e1c thu\u1ed1c ch\u1ed1ng \u0111\u1ed9ng kinh \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng \u0111\u1ec3 \u0111i\u1ec1u tr\u1ecb c\u00e1c c\u01a1n \u0111\u1ed9ng kinh v\u00e0 c\u00e1c r\u1ed1i lo\u1ea1n th\u1ea7n kinh kh\u00e1c. T\u01b0\u01a1ng t\u1ef1, c\u00e1c nh\u00f3m thu\u1ed1c kh\u00e1c tr\u00ean, Paxlovid \u0111\u01b0\u1ee3c chuy\u1ec3n h\u00f3a b\u1edfi enzyme CYP3A4 trong gan v\u00e0 c\u00f3 th\u1ec3 \u1ea3nh h\u01b0\u1edfng \u0111\u1ebfn ho\u1ea1t \u0111\u1ed9ng c\u1ee7a c\u00e1c enzyme n\u00e0y. M\u1ed9t s\u1ed1 lo\u1ea1i thu\u1ed1c ch\u1ed1ng \u0111\u1ed9ng kinh nh\u01b0 Carbamazepine, Phenytoin v\u00e0 Phenobarbital c\u0169ng \u0111\u01b0\u1ee3c chuy\u1ec3n h\u00f3a b\u1edfi c\u00f9ng m\u1ed9t enzyme. Vi\u1ec7c s\u1eed d\u1ee5ng \u0111\u1ed3ng th\u1eddi Paxlovid v\u00e0 c\u00e1c thu\u1ed1c ch\u1ed1ng \u0111\u1ed9ng kinh n\u00e0y c\u00f3 th\u1ec3 l\u00e0m t\u0103ng n\u1ed3ng \u0111\u1ed9 c\u1ee7a Paxlovid trong c\u01a1 th\u1ec3 v\u00e0 l\u00e0m gi\u1ea3m t\u00e1c d\u1ee5ng c\u1ee7a thu\u1ed1c ch\u1ed1ng \u0111\u1ed9ng kinh, g\u00e2y ra t\u0103ng nguy c\u01a1 c\u00e1c c\u01a1n \u0111\u1ed9ng kinh ho\u1eb7c c\u00e1c v\u1ea5n \u0111\u1ec1 kh\u00e1c v\u1ec1 s\u1ee9c kh\u1ecfe.<\/span><\/p>\n

2.5 T\u01b0\u01a1ng t\u00e1c thu\u1ed1c gi\u1eefa Paxlovid v\u00e0 m\u1ed9t s\u1ed1 lo\u1ea1i thu\u1ed1c tr\u1ecb \u0111au n\u1eeda \u0111\u1ea7u<\/span><\/h3>\n

Trong s\u1ed1 c\u00e1c thu\u1ed1c tr\u1ecb \u0111au n\u1eeda \u0111\u1ea7u, Eletriptan \u0111\u01b0\u1ee3c cho l\u00e0 g\u00e2y ra c\u00e1c t\u00e1c d\u1ee5ng ph\u1ee5 nghi\u00eam tr\u1ecdng li\u00ean quan \u0111\u1ebfn tim ho\u1eb7c n\u00e3o khi d\u00f9ng ngay v\u1edbi Paxlovid. Do \u0111\u00f3 n\u00ean c\u00f3 kho\u1ea3ng c\u00e1ch gi\u1eefa li\u1ec1u b\u1eaft \u0111\u1ea7u d\u00f9ng c\u1ee7a 2 thu\u1ed1c \u00edt nh\u1ea5t 3 ng\u00e0y. C\u00e1c lo\u1ea1i thu\u1ed1c tr\u1ecb \u0111au n\u1eeda \u0111\u1ea7u Triptan kh\u00e1c c\u00f3 v\u1ebb an to\u00e0n khi d\u00f9ng chung v\u1edbi Paxlovid.\u00a0<\/span><\/p>\n

2.6 T\u01b0\u01a1ng t\u00e1c thu\u1ed1c gi\u1eefa Paxlovid v\u00e0 thu\u1ed1c tr\u00e1nh thai\u00a0<\/span><\/h3>\n

Trong nh\u00f3m thu\u1ed1c tr\u00e1nh thai, c\u00e1c thu\u1ed1c c\u00f3 ch\u1ee9a ethinyl estradiol trong c\u1ea5u tr\u00fac khi s\u1eed d\u1ee5ng chung l\u00fac v\u1edbi Paxlovid c\u00f3 th\u1ec3 l\u00e0m gi\u1ea3m hi\u1ec7u qu\u1ea3 c\u1ee7a thu\u1ed1c tr\u00e1nh thai v\u00e0 l\u00e0m t\u0103ng nguy c\u01a1 mang thai ngo\u00e0i \u00fd mu\u1ed1n. Nh\u01b0ng v\u00ec Paxlovid ch\u1ec9 \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng trong 5 ng\u00e0y m\u1ed7i l\u1ea7n n\u00ean t\u01b0\u01a1ng t\u00e1c n\u00e0y v\u1eabn c\u00f3 th\u1ec3 tr\u00e1nh\u00a0<\/span><\/p>\n

2.7 T\u01b0\u01a1ng t\u00e1c thu\u1ed1c gi\u1eefa Paxlovid v\u00e0 thu\u1ed1c \u0111i\u1ec1u tr\u1ecb r\u1ed1i lo\u1ea1n c\u01b0\u01a1ng d\u01b0\u01a1ng\u00a0<\/span><\/h3>\n

Thu\u1ed1c \u1ee9c ch\u1ebf PDE-5 l\u00e0 lo\u1ea1i thu\u1ed1c ph\u1ed5 bi\u1ebfn \u0111i\u1ec1u tr\u1ecb r\u1ed1i lo\u1ea1n c\u01b0\u01a1ng d\u01b0\u01a1ng. Ch\u00fang \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng khi c\u1ea7n thi\u1ebft tr\u01b0\u1edbc khi quan h\u1ec7 t\u00ecnh d\u1ee5c. Trong \u0111\u00f3, Avanafil c\u00f3 th\u1ec3 t\u0103ng n\u1ed3ng \u0111\u1ed9 trong m\u00e1u d\u01b0\u1edbi t\u00e1c d\u1ee5ng c\u1ee7a Paxlovid n\u00ean c\u1ea7n th\u1eadn tr\u1ecdng khi s\u1eed d\u1ee5ng chung\u00a0<\/span><\/p>\n

3.K\u1ebft lu\u1eadn\u00a0<\/strong><\/h2>\n

Tr\u00ean \u0111\u00e2y l\u00e0 7 t\u01b0\u01a1ng t\u00e1c ph\u1ed5 bi\u1ebfn khi s\u1eed d\u1ee5ng Paxlovid c\u1ea7n \u0111\u01b0\u1ee3c bi\u1ebft \u0111\u1ec3 \u0111\u1ea3m b\u1ea3o an to\u00e0n v\u00e0 hi\u1ec7u qu\u1ea3 trong qu\u00e1 tr\u00ecnh \u0111i\u1ec1u tr\u1ecb COVID-19. Vi\u1ec7c s\u1eed d\u1ee5ng Paxlovid \u0111\u1ed3ng th\u1eddi v\u1edbi m\u1ed9t s\u1ed1 lo\u1ea1i thu\u1ed1c c\u00f3 th\u1ec3 g\u00e2y t\u01b0\u01a1ng t\u00e1c thu\u1ed1c v\u00e0 \u1ea3nh h\u01b0\u1edfng \u0111\u1ebfn s\u1ee9c kh\u1ecfe c\u1ee7a b\u1ec7nh nh\u00e2n. Do \u0111\u00f3, b\u1ec7nh nh\u00e2n c\u1ea7n th\u1eadn tr\u1ecdng v\u00e0 t\u00ecm ki\u1ebfm \u00fd ki\u1ebfn t\u1eeb b\u00e1c s\u0129 tr\u01b0\u1edbc khi s\u1eed d\u1ee5ng Paxlovid \u0111\u1ed3ng th\u1eddi v\u1edbi c\u00e1c lo\u1ea1i thu\u1ed1c kh\u00e1c. B\u00e1c s\u0129 c\u00f3 th\u1ec3 \u0111i\u1ec1u ch\u1ec9nh li\u1ec1u l\u01b0\u1ee3ng ho\u1eb7c thay \u0111\u1ed5i thu\u1ed1c kh\u00e1c thay th\u1ebf \u0111\u1ec3 tr\u00e1nh t\u01b0\u01a1ng t\u00e1c thu\u1ed1c kh\u00f4ng mong mu\u1ed1n \u0111\u1ec3 \u0111\u1ea3m b\u1ea3o an to\u00e0n v\u00e0 hi\u1ec7u qu\u1ea3 trong su\u1ed1t qu\u00e1 tr\u00ecnh \u0111i\u1ec1u tr\u1ecb Covid-19\u00a0<\/span><\/p>\n","protected":false},"excerpt":{"rendered":"

Paxlovid l\u00e0 m\u1ed9t lo\u1ea1i thu\u1ed1c m\u1edbi \u0111\u01b0\u1ee3c FDA (C\u1ee5c qu\u1ea3n l\u00fd th\u1ef1c ph\u1ea9m v\u00e0 d\u01b0\u1ee3c ph\u1ea9m Hoa K\u1ef3) ph\u00ea duy\u1ec7t \u0111\u1ec3 \u0111i\u1ec1u tr\u1ecb COVID-19. Tuy nhi\u00ean, nh\u01b0 v\u1edbi b\u1ea5t k\u1ef3 lo\u1ea1i thu\u1ed1c n\u00e0o kh\u00e1c, vi\u1ec7c s\u1eed d\u1ee5ng Paxlovid c\u0169ng c\u00f3 th\u1ec3 g\u00e2y t\u01b0\u01a1ng t\u00e1c thu\u1ed1c v\u00e0 \u1ea3nh h\u01b0\u1edfng \u0111\u1ebfn s\u1ee9c kh\u1ecfe c\u1ee7a b\u1ec7nh nh\u00e2n. Trong […]<\/p>\n","protected":false},"author":54,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[12],"tags":[],"yoast_head":"\n7 t\u01b0\u01a1ng t\u00e1c ph\u1ed5 bi\u1ebfn khi s\u1eed d\u1ee5ng Paxlovid c\u1ea7n bi\u1ebft - Vinmec<\/title>\n<meta name=\"description\" content=\"Paxlovid l\u00e0 m\u1ed9t lo\u1ea1i thu\u1ed1c m\u1edbi \u0111\u01b0\u1ee3c FDA ph\u00ea duy\u1ec7t \u0111\u1ec3 \u0111i\u1ec1u tr\u1ecb COVID-19. 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