{"id":27309,"date":"2023-05-04T17:11:25","date_gmt":"2023-05-04T10:11:25","guid":{"rendered":"http:\/\/noithathoaphat.in\/ctv\/?p=27309"},"modified":"2023-05-04T17:11:25","modified_gmt":"2023-05-04T10:11:25","slug":"tuong-tac-thuoc-do-doi-khang-anh-huong-den-duoc-dong-hoc","status":"publish","type":"post","link":"http:\/\/noithathoaphat.in\/ctv\/index.php\/2023\/05\/04\/tuong-tac-thuoc-do-doi-khang-anh-huong-den-duoc-dong-hoc\/","title":{"rendered":"T\u01b0\u01a1ng t\u00e1c thu\u1ed1c do \u0111\u1ed1i kh\u00e1ng \u1ea3nh h\u01b0\u1edfng \u0111\u1ebfn d\u01b0\u1ee3c \u0111\u1ed9ng h\u1ecdc"},"content":{"rendered":"<p><span style=\"font-weight: 400;\">Thu\u1ed1c \u0111\u01b0\u1ee3c \u0111\u01b0a v\u00e0o c\u01a1 th\u1ec3 b\u1eb1ng nhi\u1ec1u \u0111\u01b0\u1eddng. Sau khi \u0111\u01b0\u1ee3c h\u1ea5p thu \u0111\u1ec3 ph\u00e1t huy t\u00e1c d\u1ee5ng d\u01b0\u1ee3c l\u00fd, thu\u1ed1c \u0111\u01b0\u1ee3c coi l\u00e0 v\u1eadt l\u1ea1, c\u01a1 th\u1ec3 s\u1ebd t\u00ecm m\u1ecdi c\u00e1ch \u0111\u1ec3 th\u1ea3i tr\u1eeb. Trong m\u1ed7i giai \u0111o\u1ea1n trong c\u01a1 th\u1ec3 ng\u01b0\u1eddi, c\u00e1c thu\u1ed1c s\u1ebd g\u1eb7p nhau v\u00e0 t\u01b0\u01a1ng t\u00e1c l\u1eabn nhau, \u0111\u1ec3 cho k\u1ebft qu\u1ea3 l\u00e2m s\u00e0ng, ho\u1eb7c c\u00f3 l\u1ee3i, ho\u1eb7c c\u00f3 h\u1ea1i. T\u01b0\u01a1ng t\u00e1c thu\u1ed1c l\u00e0 hi\u1ec7n t\u01b0\u1ee3ng x\u1ea3y ra khi hai ho\u1eb7c nhi\u1ec1u lo\u1ea1i thu\u1ed1c \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng c\u00f9ng nhau v\u00e0 g\u00e2y ra t\u00e1c \u0111\u1ed9ng l\u00ean c\u01a1 th\u1ec3. Thu\u1ed1c c\u00f2n g\u1eb7p th\u1ee9c \u0103n, \u0111\u1ed3 u\u1ed1ng, n\u00ean c\u00f2n c\u00f3 t\u01b0\u01a1ng t\u00e1c <i>thu\u1ed1c &#8211; th\u1ee9c \u0103n<\/i>.<\/span><\/p>\n<p><span style=\"font-weight: 400;\"> \u00a0S\u01a1 \u0111\u1ed3 sau \u0111\u00e2y cho th\u1ea5y s\u1ef1 v\u1eadn chuy\u1ec3n c\u1ee7a thu\u1ed1c trong c\u01a1 th\u1ec3 t\u1eeb l\u00fac h\u1ea5p thu \u0111\u1ebfn khi b\u1ecb th\u1ea3i tr\u1eeb:<\/span><\/p>\n<figure id=\"attachment_27312\" aria-describedby=\"caption-attachment-27312\" style=\"width: 2008px\" class=\"wp-caption aligncenter\"><img decoding=\"async\" loading=\"lazy\" class=\"size-full wp-image-27312\" src=\"http:\/\/noithathoaphat.in\/ctv\/wp-content\/uploads\/2023\/04\/So-do-tac-dung-cua-thuoc.jpg\" alt=\"S\u1ef1 v\u1eadn chuy\u1ec3n c\u1ee7a thu\u1ed1c trong c\u01a1 th\u1ec3\" width=\"2008\" height=\"1299\" srcset=\"http:\/\/noithathoaphat.in\/ctv\/wp-content\/uploads\/2023\/04\/So-do-tac-dung-cua-thuoc.jpg 2008w, http:\/\/noithathoaphat.in\/ctv\/wp-content\/uploads\/2023\/04\/So-do-tac-dung-cua-thuoc-300x194.jpg 300w, http:\/\/noithathoaphat.in\/ctv\/wp-content\/uploads\/2023\/04\/So-do-tac-dung-cua-thuoc-1024x662.jpg 1024w, http:\/\/noithathoaphat.in\/ctv\/wp-content\/uploads\/2023\/04\/So-do-tac-dung-cua-thuoc-768x497.jpg 768w, http:\/\/noithathoaphat.in\/ctv\/wp-content\/uploads\/2023\/04\/So-do-tac-dung-cua-thuoc-1536x994.jpg 1536w\" sizes=\"(max-width: 2008px) 100vw, 2008px\" \/><figcaption id=\"caption-attachment-27312\" class=\"wp-caption-text\">S\u1ef1 v\u1eadn chuy\u1ec3n c\u1ee7a thu\u1ed1c trong c\u01a1 th\u1ec3<\/figcaption><\/figure>\n<p><span style=\"font-weight: 400;\">Trong qu\u00e1 tr\u00ecnh h\u1ea5p thu, ph\u00e2n b\u1ed1, chuy\u1ec3n h\u00f3a, t\u00edch l\u0169y v\u00e0 \u0111\u00e0o th\u1ea3i, thu\u1ed1c ph\u1ea3i v\u01b0\u1ee3t qua nhi\u1ec1u m\u00e0ng sinh h\u1ecdc \u0111\u1ec3 sang v\u1ecb tr\u00ed m\u1edbi. C\u00f3 ba giai \u0111o\u1ea1n ch\u00ednh:<\/span><\/p>\n<p><b><i>&#8211;\u00a0 H\u1ea5p thu: <\/i><\/b><span style=\"font-weight: 400;\">Thu\u1ed1c t\u1eeb n\u01a1i ti\u1ebfp nh\u1eadn (u\u1ed1ng, ti\u00eam d\u01b0\u1edbi da, ti\u00eam b\u1eafp, \u0111\u1eb7t tr\u1ef1c tr\u00e0ng&#8230;) chuy\u1ec3n v\u00e0o v\u00f2ng \u0111\u1ea1i tu\u1ea7n ho\u00e0n.<\/span><\/p>\n<p><b><i>&#8211;\u00a0 Ph\u00e2n b\u1ed1: <\/i><\/b><span style=\"font-weight: 400;\">Trong m\u00e1u, thu\u1ed1c k\u1ebft h\u1ee3p v\u1edbi protein &#8211; huy\u1ebft t\u01b0\u01a1ng; ph\u1ea7n kh\u00f4ng k\u1ebft h\u1ee3p s\u1ebd chuy\u1ec3n v\u00e0o c\u00e1c m\u00f4, r\u1ed3i g\u1eafn v\u1edbi th\u1ee5 th\u1ec3 \u0111\u1eb7c hi\u1ec7u, \u0111\u1ebfn v\u1ecb tr\u00ed \u0111\u00edch \u0111\u1ec3 ph\u00e1t huy ho\u1ea1t t\u00ednh.<\/span><\/p>\n<p><b><i>&#8211;\u00a0 Chuy\u1ec3n h\u00f3a v\u00e0 \u0111\u00e0o th\u1ea3i: <\/i><\/b><span style=\"font-weight: 400;\">Thu\u1ed1c \u0111\u01b0\u1ee3c chuy\u1ec3n h\u00f3a, ch\u1ea5t chuy\u1ec3n h\u00f3a s\u1ebd th\u1ea3i qua th\u1eadn, qua m\u1eadt ho\u1eb7c qua c\u00e1c n\u01a1i kh\u00e1c.<\/span><\/p>\n<p>&nbsp;<\/p>\n<h2><b><i>\u0110\u1ed1i kh\u00e1ng do \u1ea3nh h\u01b0\u1edfng t\u1edbi d\u01b0\u1ee3c \u0111\u1ed9ng h\u1ecdc<\/i><\/b><\/h2>\n<ol>\n<li>\n<h3><strong>C\u1ea3n tr\u1edf h\u1ea5p thu qua \u1ed1ng ti\u00eau h\u00f3a<\/strong><\/h3>\n<\/li>\n<\/ol>\n<ul>\n<li><span style=\"font-weight: 400;\"><a href=\"https:\/\/vinmec.com\/vi\/thong-tin-duoc\/su-dung-thuoc-toan\/cong-dung-cua-aluminum-hydroxide\/\">Nh\u00f4m hydroxyd<\/a> c\u1ea3n tr\u1edf h\u1ea5p thu phosphat, INH, doxycyclin<\/span><span style=\"font-weight: 400;\">\u2026<\/span><span style=\"font-weight: 400;\"> carbonat l\u00e0m gi\u1ea3m h\u1ea5p thu s\u1eaft qua \u1ed1ng ti\u00eau h\u00f3a.<\/span><\/li>\n<li><span style=\"font-weight: 400;\"><a href=\"https:\/\/vinmec.com\/vi\/thong-tin-duoc\/su-dung-thuoc-toan\/mot-so-nhom-thuoc-thuong-duoc-su-dung-trong-dieu-tri-viem-loet-da-day\/#:~:text=Thu%E1%BB%91c%20trung%20h%C3%B2a%20axit%20d%E1%BA%A1,ng%C6%B0%E1%BB%A3c%20d%E1%BA%A1%20d%C3%A0y%20th%E1%BB%B1c%20qu%E1%BA%A3n.\">Thu\u1ed1c ch\u1ed1ng toan d\u1ea1 d\u00e0y<\/a> l\u00e0m t\u0103ng pH trong d\u1ecbch \u1ed1ng ti\u00eau h\u00f3a, n\u00ean ng\u0103n c\u1ea3n s\u1ef1 h\u1ea5p thu c\u1ee7a nh\u1eefng thu\u1ed1c l\u00e0 acid y\u1ebfu (phenylbutazon, ketoconazol, aspirin, sulfamid, m\u1ed9t s\u1ed1 barbiturat, coumarin ch\u1ed1ng \u0111\u00f4ng&#8230;).<\/span><\/li>\n<li><span style=\"font-weight: 400;\"><a href=\"https:\/\/www.vinmec.com\/vi\/thong-tin-duoc\/su-dung-thuoc-toan\/tim-hieu-ve-thuoc-khang-cholinergic\/\">Thu\u1ed1c kh\u00e1ng cholinergic<\/a>, <a href=\"https:\/\/www.vinmec.com\/vi\/thong-tin-duoc\/su-dung-thuoc-toan\/thuoc-khang-histamin-la-gi-va-cach-su-dung-hop-ly\/\">thu\u1ed1c \u1ee9c ch\u1ebf histamin H<\/a><\/span><span style=\"font-weight: 400;\">2<\/span><span style=\"font-weight: 400;\"> (nh\u01b0 cimetidin), thu\u1ed1c \u1ee9c ch\u1ebf b\u01a1m proton (nh\u01b0 omeprazol) c\u0169ng l\u00e0m t\u0103ng pH d\u1ea1 d\u00e0y, n\u00ean l\u00e0m gi\u1ea3m h\u00f2a tan, gi\u1ea3m h\u1ea5p thu ketoconazol (u\u1ed1ng). Khi c\u1ea7n, ph\u1ea3i u\u1ed1ng ketoconazol tr\u01b0\u1edbc 2 gi\u1edd.<\/span><\/li>\n<li><span style=\"font-weight: 400;\">Thu\u1ed1c kh\u00e1ng sinh di\u1ec7t vi khu\u1ea9n c\u00f3 \u00edch \u1edf ru\u1ed9t, ng\u0103n c\u1ea3n t\u1ed5ng h\u1ee3p c\u00e1c vitamin E, K. Thu\u1ed1c nhu\u1eadn tr\u00e0ng lo\u1ea1i mu\u1ed1i (magnesi sulfat, natri sulfat), cisaprid, metoclopramid l\u00e0m t\u0103ng nhu \u0111\u1ed9ng c\u1ee7a \u1ed1ng ti\u00eau h\u00f3a n\u00ean l\u00e0m gi\u1ea3m h\u1ea5p thu nhi\u1ec1u thu\u1ed1c (do b\u1ecb t\u1ed1ng nhanh kh\u1ecfi ru\u1ed9t).<\/span><\/li>\n<li><span style=\"font-weight: 400;\">Thu\u1ed1c ng\u1eeba thai (u\u1ed1ng) b\u1ecb li\u00ean h\u1ee3p \u1edf gan (chuy\u1ec3n h\u00f3a pha II; xem \u1edf c\u00e1c trang sau), r\u1ed3i t\u1edbi ru\u1ed9t, theo chu k\u1ef3 ru\u1ed9t &#8211; gan, quay tr\u1edf l\u1ea1i gan \u0111\u1ec3 duy tr\u00ec hi\u1ec7u l\u1ef1c. D\u00f9ng kh\u00e1ng sinh ph\u1ed5 r\u1ed9ng c\u00f3 th\u1ec3 l\u00e0m r\u1ed1i lo\u1ea1n h\u1ec7 vi khu\u1ea9n trong ru\u1ed9t, nh\u1eefng vi khu\u1ea9n c\u00f3 \u00edch b\u1ecb ti\u00eau di\u1ec7t n\u00ean kh\u00f4ng \u0111\u1ee7 \u0111\u1ec3 ph\u00e1 d\u1ea1ng li\u00ean h\u1ee3p c\u1ee7a thu\u1ed1c ng\u1eeba thai nh\u01b0 th\u01b0\u1eddng l\u1ec7, thu\u1ed1c kh\u00f4ng theo chu k\u1ef3 quay tr\u1edf l\u1ea1i gan \u0111\u01b0\u1ee3c, ph\u1ea3i th\u1ea3i theo ph\u00e2n. H\u1eadu qu\u1ea3 c\u00f3 th\u1ec3 l\u00e0 mang thai ngo\u00e0i \u00fd mu\u1ed1n.<\/span><\/li>\n<\/ul>\n<p><span style=\"font-weight: 400;\">V\u1edbi thu\u1ed1c u\u1ed1ng d\u00e0i ng\u00e0y, m\u1ed7i ng\u00e0y nhi\u1ec1u l\u1ea7n (nh\u01b0 thu\u1ed1c ch\u1ed1ng \u0111\u00f4ng m\u00e1u), th\u00ec \u1ea3nh h\u01b0\u1edfng t\u1edbi t\u1ed1c \u0111\u1ed9 h\u1ea5p thu kh\u00f4ng quan tr\u1ecdng, v\u00ec t\u1ed5ng l\u01b0\u1ee3ng h\u1ea5p thu kh\u00f4ng thay \u0111\u1ed5i \u0111\u00e1ng k\u1ec3. Nh\u01b0ng v\u1edbi c\u00e1c thu\u1ed1c d\u00f9ng li\u1ec1u duy nh\u1ea5t h\u1eb1ng ng\u00e0y, c\u1ea7n h\u1ea5p thu nhanh (nh\u01b0 thu\u1ed1c ng\u1ee7, gi\u1ea3m \u0111au), c\u1ea7n c\u00f3 nhanh n\u1ed3ng \u0111\u1ed9 cao trong m\u00e1u, th\u00ec t\u01b0\u01a1ng t\u00e1c n\u00e0o l\u00e0m ch\u1eadm t\u1ed1c \u0111\u1ed9 h\u1ea5p thu qua \u1ed1ng ti\u00eau h\u00f3a (t\u00e1c d\u1ee5ng \u0111\u1ed1i kh\u00e1ng) s\u1ebd d\u1ec5 l\u00e0m gi\u1ea3m ho\u1ea1t t\u00ednh c\u1ee7a thu\u1ed1c.<\/span><\/p>\n<h3><strong>\u00a0 \u00a0 \u00a02. \u0110\u1ed1i kh\u00e1ng \u1edf kh\u00e2u chuy\u1ec3n h\u00f3a<\/strong><\/h3>\n<p><span style=\"font-weight: 400;\">C\u00f3 thu\u1ed1c v\u00e0o c\u01a1 th\u1ec3, r\u1ed3i th\u1ea3i nguy\u00ean v\u1eb9n, kh\u00f4ng qua chuy\u1ec3n h\u00f3a (nh\u01b0 bromid, saccharin, lithi, m\u1ed9t s\u1ed1 kh\u00e1ng sinh nh\u00f3m aminoglycosid&#8230;). C\u00f3 thu\u1ed1c khi u\u1ed1ng b\u1ecb trung h\u00f2a ngay b\u1edfi d\u1ecbch v\u1ecb, nh\u01b0 natri bicarbonat. Nh\u01b0ng nhi\u1ec1u thu\u1ed1c sau khi h\u1ea5p thu, ph\u1ea3i \u0111\u01b0\u1ee3c chuy\u1ec3n h\u00f3a, r\u1ed3i m\u1edbi th\u1ea3i. Nh\u1eefng ch\u1ea5t v\u1eeba \u0111\u01b0\u1ee3c chuy\u1ec3n h\u00f3a (metabolit) s\u1ebd c\u00f3 t\u00ednh ph\u00e2n c\u1ef1c (polarity) cao, \u00edt tan trong lipid h\u01a1n ch\u1ea5t ban \u0111\u1ea7u, d\u1ec5 tan trong n\u01b0\u1edbc h\u01a1n, n\u00ean kh\u00f3 khu\u1ebfch t\u00e1n th\u1ee5 \u0111\u1ed9ng qua c\u00e1c m\u00e0ng sinh h\u1ecdc trong c\u01a1 th\u1ec3, do \u0111\u00f3 d\u1ec5 th\u1ea3i h\u01a1n. Th\u00f4ng th\u01b0\u1eddng, sau khi chuy\u1ec3n h\u00f3a, thu\u1ed1c s\u1ebd m\u1ea5t t\u00e1c d\u1ee5ng, m\u1ea5t \u0111\u1ed9c t\u00ednh.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Gan gi\u1eef vai tr\u00f2 quan tr\u1ecdng nh\u1ea5t trong chuy\u1ec3n h\u00f3a thu\u1ed1c. Nhi\u1ec1u enzym x\u00fac t\u00e1c cho chuy\u1ec3n h\u00f3a thu\u1ed1c n\u1eb1m \u1edf m\u00e0ng l\u01b0\u1edbi n\u1ed9i b\u00e0o kh\u00f4ng h\u1ea1t c\u1ee7a t\u1ebf b\u00e0o gan (<\/span><b>S<\/b><span style=\"font-weight: 400;\">mooth &#8211; surfaced <\/span><b>E<\/b><span style=\"font-weight: 400;\">ndoplasmic <\/span><b>R<\/b><span style=\"font-weight: 400;\">eticulum; <\/span><b>SER<\/b><span style=\"font-weight: 400;\">). \u1ede c\u00e1c h\u1ec7 enzym c\u1ee7a d\u1ecbch c\u01a1 th\u1ec3 c\u0169ng c\u00f3 m\u1ed9t s\u1ed1 enzym x\u00fac t\u00e1c cho chuy\u1ec3n h\u00f3a thu\u1ed1c, nh\u01b0 huy\u1ebft t\u01b0\u01a1ng c\u00f3 esterase gi\u00fap th\u1ee7y ph\u00e2n ester (procain, cocain, acetylcholin, suxamethonium&#8230;).<\/span><\/p>\n<p><b><i>l<\/i><\/b><b><i>Nh\u1eefng ph\u1ea3n \u1ee9ng gi\u00e1ng h\u00f3a<\/i><\/b><\/p>\n<p><span style=\"font-weight: 400;\">\u0110\u00e2y l\u00e0 nh\u1eefng ph\u1ea3n \u1ee9ng oxy h\u00f3a, kh\u1eed ho\u1eb7c th\u1ee7y ph\u00e2n (g\u1ecdi chung l\u00e0 ph\u1ea3n \u1ee9ng pha I).<\/span><\/p>\n<p><i><span style=\"font-weight: 400;\">Ph\u1ea3n \u1ee9ng oxy h\u00f3a<\/span><\/i><\/p>\n<p><span style=\"font-weight: 400;\">+<\/span><b> \u00a0 <\/b><span style=\"font-weight: 400;\">Oxy h\u00f3a thu\u1ed1c qua s\u1ef1 x\u00fac t\u00e1c enzym c\u1ee7a l\u01b0\u1edbi n\u1ed9i b\u00e0o kh\u00f4ng h\u1ea1t c\u1ee7a t\u1ebf b\u00e0o gan. Th\u00f4ng th\u01b0\u1eddng, c\u00e1c y\u1ebfu t\u1ed1 c\u00f3 ho\u1ea1t t\u00ednh enzym oxy h\u00f3a thu\u1ed1c thu\u1ed9c lo\u1ea1i n\u00e0y g\u1ecdi l\u00e0 &#8220;microsom&#8221;.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Nh\u1eefng lo\u1ea1i ph\u1ea3n \u1ee9ng ch\u00ednh g\u1ed3m: hydroxyl h\u00f3a \u1edf nh\u00e2n th\u01a1m ho\u1eb7c \u1edf chu\u1ed7i th\u1eb3ng, oxy h\u00f3a N<\/span><span style=\"font-weight: 400;\">&#8211;<\/span><span style=\"font-weight: 400;\"> m\u1ea5t alkyl, oxy h\u00f3a O<\/span><span style=\"font-weight: 400;\">&#8211;<\/span><span style=\"font-weight: 400;\"> m\u1ea5t alkyl<\/span><span style=\"font-weight: 400;\">&#8230;<\/span><\/p>\n<p><span style=\"font-weight: 400;\">H\u1ec7 enzym quan tr\u1ecdng nh\u1ea5t cho chuy\u1ec3n h\u00f3a pha I l\u00e0 cytochrom P<\/span><span style=\"font-weight: 400;\">450<\/span><span style=\"font-weight: 400;\"> (vi\u1ebft t\u1eaft: CYP), l\u00e0 m\u1ed9t h\u1ecd l\u1edbn c\u1ee7a microsom, g\u1ed3m c\u00e1c isoenzym chuy\u1ec3n electron, qua \u0111\u00f3 x\u00fac t\u00e1c cho s\u1ef1 oxy h\u00f3a c\u1ee7a r\u1ea5t nhi\u1ec1u thu\u1ed1c. Nh\u1eefng electron n\u00e0y do enzym NADPH \u2013 cytochrom P<\/span><span style=\"font-weight: 400;\">450<\/span><span style=\"font-weight: 400;\"> &#8211; reductase v\u1eadn chuy\u1ec3n t\u1eeb NADPH \u0111\u01b0a t\u1edbi cytochrom P<\/span><span style=\"font-weight: 400;\">450<\/span><span style=\"font-weight: 400;\">. C\u00e1c enzym cytochrom P<\/span><span style=\"font-weight: 400;\">450<\/span><span style=\"font-weight: 400;\"> \u0111\u01b0\u1ee3c s\u1eafp x\u1ebfp v\u00e0o 14 h\u1ecd gen c\u1ee7a \u0111\u1ed9ng v\u1eadt c\u00f3 v\u00fa v\u00e0 17 d\u01b0\u1edbi l\u1edbp (sub-families), \u0111\u01b0\u1ee3c vi\u1ebft theo quy \u01b0\u1edbc sau:<\/span><\/p>\n<p><span style=\"font-weight: 400;\">V\u00ed d\u1ee5: CYP<\/span><span style=\"font-weight: 400;\">3<\/span><span style=\"font-weight: 400;\">A<\/span><span style=\"font-weight: 400;\">4<\/span><span style=\"font-weight: 400;\">, trong \u0111\u00f3 CYP = cytochrom P<\/span><span style=\"font-weight: 400;\">450<\/span><span style=\"font-weight: 400;\">; c\u00f2n 3 l\u00e0 h\u1ecd; A = d\u01b0\u1edbi l\u1edbp; 4 = gen \u0111\u1eb7c hi\u1ec7u.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">V\u1edbi \u0111\u1ed9ng v\u1eadt c\u00f3 v\u00fa v\u00e0 ng\u01b0\u1eddi, c\u00e1c enzym quan tr\u1ecdng nh\u1ea5t cho chuy\u1ec3n h\u00f3a thu\u1ed1c l\u00e0 CYP<\/span><span style=\"font-weight: 400;\">1<\/span><span style=\"font-weight: 400;\">A<\/span><span style=\"font-weight: 400;\">2<\/span><span style=\"font-weight: 400;\">, CYP<\/span><span style=\"font-weight: 400;\">2<\/span><span style=\"font-weight: 400;\">C<\/span><span style=\"font-weight: 400;\">9<\/span><span style=\"font-weight: 400;\">, CYP<\/span><span style=\"font-weight: 400;\">2<\/span><span style=\"font-weight: 400;\">C<\/span><span style=\"font-weight: 400;\">19<\/span><span style=\"font-weight: 400;\">, CYP<\/span><span style=\"font-weight: 400;\">2<\/span><span style=\"font-weight: 400;\">D<\/span><span style=\"font-weight: 400;\">6<\/span><span style=\"font-weight: 400;\">, CYP<\/span><span style=\"font-weight: 400;\">3<\/span><span style=\"font-weight: 400;\">A<\/span><span style=\"font-weight: 400;\">4<\/span><span style=\"font-weight: 400;\">.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">T\u00ednh \u0111\u1eb7c hi\u1ec7u c\u1ee7a c\u00e1c CYP n\u00e0y r\u1ea5t quan tr\u1ecdng \u0111\u1ec3 c\u1eaft ngh\u0129a v\u1ec1 t\u01b0\u01a1ng t\u00e1c \u1edf kh\u00e2u chuy\u1ec3n h\u00f3a thu\u1ed1c.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">+<\/span> <span style=\"font-weight: 400;\">Ph\u1ea3n \u1ee9ng oxy h\u00f3a kh\u00e1c: v\u00ed d\u1ee5 oxy h\u00f3a r\u01b0\u1ee3u v\u00e0 aldehyd nh\u1edd x\u00fac t\u00e1c c\u1ee7a alcol<\/span> <span style=\"font-weight: 400;\">dehydrogenase v\u00e0 aldehyd dehydrogenase.<\/span><\/p>\n<p><i><span style=\"font-weight: 400;\">Ph\u1ea3n \u1ee9ng th\u1ee7y ph\u00e2n<\/span><\/i><\/p>\n<p><span style=\"font-weight: 400;\">C\u00e1c ester, amid b\u1ecb th\u1ee7y ph\u00e2n nh\u1edd x\u00fac t\u00e1c c\u1ee7a esterase, amidase.<\/span><\/p>\n<p><b><i>l\u00a0 Nh\u1eefng ph\u1ea3n \u1ee9ng li\u00ean h\u1ee3p (ph\u1ea3n \u1ee9ng pha II)<\/i><\/b><\/p>\n<p><span style=\"font-weight: 400;\">Sau khi gi\u00e1ng h\u00f3a \u1edf pha I, ch\u1ea5t chuy\u1ec3n h\u00f3a v\u1eeba t\u1ea1o th\u00e0nh c\u00f3 th\u1ec3 li\u00ean h\u1ee3p v\u1edbi c\u00e1c ch\u1ea5t s\u1eb5n c\u00f3 trong c\u01a1 th\u1ec3 (nh\u01b0 c\u00e1c acid glucuronic, acetic, sulfuric, mercapturic ho\u1eb7c glycocol, glutathion), \u0111\u1ec3 cu\u1ed1i c\u00f9ng cho ch\u1ea5t li\u00ean h\u1ee3p \u00edt tan trong lipid h\u01a1n, t\u00ednh ph\u00e2n c\u1ef1c m\u1ea1nh h\u01a1n, d\u1ec5 tan trong n\u01b0\u1edbc h\u01a1n, \u0111\u1ec3 cu\u1ed1i c\u00f9ng l\u00e0 ho\u00e0n thi\u1ec7n kh\u00e2u th\u1ea3i qua th\u1eadn, qua m\u1eadt&#8230; v\u00e0 m\u1ea5t \u0111\u1ed9c t\u00ednh.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Nhi\u1ec1u thu\u1ed1c c\u00f3 th\u1ec3 \u1ee9c ch\u1ebf c\u00e1c d\u01b0\u1edbi l\u1edbp c\u1ee7a cytochrom P<\/span><span style=\"font-weight: 400;\">450<\/span><span style=\"font-weight: 400;\"> (pha I) v\u00e0 enzym UDP &#8211; glucuronyl &#8211; transferase (x\u00fac t\u00e1c cho s\u1ef1 li\u00ean h\u1ee3p c\u1ee7a thu\u1ed1c v\u1edbi acid glucuronic \u1edf ph\u1ea3n \u1ee9ng chuy\u1ec3n h\u00f3a pha II), c\u00f3 thu\u1ed1c l\u1ea1i g\u00e2y c\u1ea3m \u1ee9ng, l\u00e0m t\u0103ng sinh CYP v\u00e0 UDP &#8211; glucuronyl &#8211; transferase, cho n\u00ean trong t\u1eebng giai \u0111o\u1ea1n c\u1ee7a s\u1ef1 chuy\u1ec3n h\u00f3a k\u1ec3 tr\u00ean, c\u00e1c thu\u1ed1c c\u00f3 th\u1ec3 t\u01b0\u01a1ng t\u00e1c v\u1edbi nhau \u0111\u1ec3 cho, ho\u1eb7c t\u00e1c d\u1ee5ng \u0111\u1ed1i kh\u00e1ng, ho\u1eb7c t\u00e1c d\u1ee5ng hi\u1ec7p \u0111\u1ed3ng, c\u00f3 l\u1ee3i ho\u1eb7c c\u00f3 h\u1ea1i cho ng\u01b0\u1eddi b\u1ec7nh, t\u00f9y thu\u1ed9c c\u00e1ch t\u01b0\u01a1ng t\u00e1c c\u1ee7a thu\u1ed1c.<\/span><\/p>\n<p><b><i>l\u00a0C\u1ea3m \u1ee9ng enzym chuy\u1ec3n h\u00f3a thu\u1ed1c \u1edf gan<\/i><\/b><\/p>\n<p><span style=\"font-weight: 400;\">Barbiturat (nh\u01b0 phenobarbital), <a href=\"https:\/\/www.vinmec.com\/vi\/thong-tin-duoc\/su-dung-thuoc-toan\/cong-dung-thuoc-doxycyclin-100mg\/\">doxycyclin<\/a>, <a href=\"https:\/\/www.vinmec.com\/vi\/thong-tin-duoc\/su-dung-thuoc-toan\/cong-dung-thuoc-spironolacton-25mg\/\">spironolacton<\/a>, <a href=\"https:\/\/www.vinmec.com\/vi\/thong-tin-duoc\/su-dung-thuoc-toan\/cong-dung-thuoc-rifampicin-300mg\/\">rifampicin<\/a>, glutethimid, <a href=\"https:\/\/www.vinmec.com\/vi\/thong-tin-duoc\/su-dung-thuoc-toan\/luu-y-khi-dung-thuoc-carbamazepin\/\">carbamazepin<\/a>, <a href=\"https:\/\/www.vinmec.com\/vi\/thong-tin-duoc\/su-dung-thuoc-toan\/cong-dung-thuoc-phenytoin-100mg\/\">phenytoin<\/a>, nghi\u1ec7n thu\u1ed1c l\u00e1, DDT&#8230; g\u00e2y c\u1ea3m \u1ee9ng cytocrom P<\/span><span style=\"font-weight: 400;\">450<\/span><span style=\"font-weight: 400;\"> (CYP), s\u1ebd l\u00e0m t\u0103ng l\u01b0\u1ee3ng CYP<\/span> <span style=\"font-weight: 400;\">m\u1edbi sinh<\/span> <span style=\"font-weight: 400;\">(kh\u00f4ng l\u00e0m t\u0103ng l\u01b0\u1ee3ng CYP \u0111\u00e3 c\u00f3), k\u1ebft qu\u1ea3 l\u00e0 l\u00e0m cho nhi\u1ec1u thu\u1ed1c kh\u00e1c chuy\u1ec3n h\u00f3a m\u1ea1nh qua gan (c\u0169ng l\u00e0 t\u0103ng thanh l\u1ecdc) v\u00e0 m\u1ea5t nhanh t\u00e1c d\u1ee5ng.<\/span><\/p>\n<figure id=\"attachment_27336\" aria-describedby=\"caption-attachment-27336\" style=\"width: 1890px\" class=\"wp-caption aligncenter\"><img decoding=\"async\" loading=\"lazy\" class=\"size-full wp-image-27336\" src=\"http:\/\/noithathoaphat.in\/ctv\/wp-content\/uploads\/2023\/04\/So-do-chuyen-hoa-thuoc-1.jpg\" alt=\"S\u01a1 \u0111\u1ed3 chuy\u1ec3n h\u00f3a thu\u1ed1c\" width=\"1890\" height=\"709\" srcset=\"http:\/\/noithathoaphat.in\/ctv\/wp-content\/uploads\/2023\/04\/So-do-chuyen-hoa-thuoc-1.jpg 1890w, http:\/\/noithathoaphat.in\/ctv\/wp-content\/uploads\/2023\/04\/So-do-chuyen-hoa-thuoc-1-300x113.jpg 300w, http:\/\/noithathoaphat.in\/ctv\/wp-content\/uploads\/2023\/04\/So-do-chuyen-hoa-thuoc-1-1024x384.jpg 1024w, http:\/\/noithathoaphat.in\/ctv\/wp-content\/uploads\/2023\/04\/So-do-chuyen-hoa-thuoc-1-768x288.jpg 768w, http:\/\/noithathoaphat.in\/ctv\/wp-content\/uploads\/2023\/04\/So-do-chuyen-hoa-thuoc-1-1536x576.jpg 1536w\" sizes=\"(max-width: 1890px) 100vw, 1890px\" \/><figcaption id=\"caption-attachment-27336\" class=\"wp-caption-text\">S\u01a1 \u0111\u1ed3 chuy\u1ec3n h\u00f3a thu\u1ed1c<\/figcaption><\/figure>\n<p><span style=\"font-weight: 400;\">V\u00ed d\u1ee5, ph\u1ee5 n\u1eef b\u1ecb lao d\u00f9ng rifampicin ho\u1eb7c b\u1ecb \u0111\u1ed9ng kinh d\u00f9ng phenobarbital, phenytoin, carbamazepin d\u1ec5 &#8220;v\u1ee1 k\u1ebf ho\u1ea1ch&#8221; do ho\u1ea1t ch\u1ea5t c\u1ee7a thu\u1ed1c ch\u1ed1ng th\u1ee5 thai b\u1ecb t\u0103ng nhanh chuy\u1ec3n h\u00f3a, m\u1ea5t t\u00e1c d\u1ee5ng ng\u1eeba thai (rifampicin, phenobarbital, phenytoin, carbamazepin l\u00e0 nh\u1eefng thu\u1ed1c g\u00e2y c\u1ea3m \u1ee9ng m\u1ea1nh CYP v\u00e0 UDP &#8211; glucuronyl &#8211; transferase \u1edf gan).<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Rifampicin c\u00f3 th\u1ec3 l\u00e0m INH t\u0103ng nhanh chuy\u1ec3n h\u00f3a qua CYP, t\u1ea1o n\u00ean nh\u1eefng ch\u1ea5t chuy\u1ec3n h\u00f3a g\u00e2y \u0111\u1ed9c.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Pyridoxin (vitamin B<\/span><span style=\"font-weight: 400;\">6<\/span><span style=\"font-weight: 400;\">) g\u00e2y c\u1ea3m \u1ee9ng dopa &#8211; decarboxylase l\u00e0m t\u0103ng ph\u1ea3n \u1ee9ng kh\u1eed carboxyl c\u1ee7a levodopa, n\u00ean levodopa b\u1ecb chuy\u1ec3n th\u00e0nh dopamin \u1edf t\u1ea1i ngay m\u00f4 ngo\u1ea1i bi\u00ean (nh\u01b0\u1ee3c \u0111i\u1ec3m). Dopamin s\u1ebd kh\u00f4ng v\u01b0\u1ee3t qua \u0111\u01b0\u1ee3c h\u00e0ng r\u00e0o m\u00e1u &#8211; n\u00e3o \u0111\u1ec3 ch\u1eefa b\u1ec7nh Parkinson. C\u1ea7n ph\u1ed1i h\u1ee3p levodopa v\u1edbi carbidopa (l\u00e0 ch\u1ea5t \u1ee9c ch\u1ebf decarboxylase ngo\u1ea1i bi\u00ean) \u0111\u1ec3 b\u1ea3o v\u1ec7 levodopa, tr\u00e1nh b\u1ecb h\u1ee7y s\u1edbm b\u1edfi vitamin B<\/span><span style=\"font-weight: 400;\">6<\/span><span style=\"font-weight: 400;\"> \u1edf m\u00f4 ngo\u1ea1i bi\u00ean.<\/span><\/p>\n<p><b><i>l\u00a0Ng\u0103n c\u1ea3n t\u00e1i h\u1ea5p thu qua \u1ed1ng th\u1eadn<\/i><\/b><\/p>\n<p><span style=\"font-weight: 400;\">Ki\u1ec1m h\u00f3a n\u01b0\u1edbc ti\u1ec3u s\u1ebd l\u00e0m t\u0103ng \u0111\u00e0o th\u1ea3i nh\u1eefng thu\u1ed1c l\u00e0 acid y\u1ebfu. Ng\u01b0\u1ee3c l\u1ea1i, acid h\u00f3a n\u01b0\u1edbc ti\u1ec3u s\u1ebd l\u00e0m t\u0103ng th\u1ea3i nh\u1eefng thu\u1ed1c l\u00e0 ki\u1ec1m y\u1ebfu.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Natri bicarbonat (ki\u1ec1m) gi\u00fap t\u0103ng th\u1ea3i phenobarbital, salicylat (acid); amoni clorid (acid) l\u00e0m t\u0103ng th\u1ea3i amphetamin (ki\u1ec1m). V\u00ed d\u1ee5, 54,5% c\u1ee7a li\u1ec1u d\u00f9ng dextroamphetamin (ki\u1ec1m) s\u1ebd th\u1ea3i trong v\u00f2ng 16 gi\u1edd n\u1ebfu n\u01b0\u1edbc ti\u1ec3u \u0111\u01b0\u1ee3c gi\u1eef \u1edf pH ~ 5, nh\u01b0ng ch\u1ec9 th\u1ea3i 2,9% c\u0169ng trong th\u1eddi gian n\u00e0y, n\u1ebfu pH n\u01b0\u1edbc ti\u1ec3u l\u00e0 ~ 8.<\/span><\/p>\n<p>C\u00f3 th\u1ec3 nh\u1eadn th\u1ea5y r\u1eb1ng t\u01b0\u01a1ng t\u00e1c thu\u1ed1c l\u00e0 m\u1ed9t v\u1ea5n \u0111\u1ec1 quan tr\u1ecdng trong y h\u1ecdc hi\u1ec7n \u0111\u1ea1i v\u00e0 \u0111\u1eb7c bi\u1ec7t l\u00e0 trong l\u00e2m s\u00e0ng. T\u01b0\u01a1ng t\u00e1c thu\u1ed1c c\u00f3 th\u1ec3 \u1ea3nh h\u01b0\u1edfng \u0111\u1ebfn d\u01b0\u1ee3c \u0111\u1ed9ng h\u1ecdc c\u1ee7a c\u00e1c lo\u1ea1i thu\u1ed1c, g\u00e2y ra s\u1ef1 thay \u0111\u1ed5i trong n\u1ed3ng \u0111\u1ed9 thu\u1ed1c, t\u1ed1c \u0111\u1ed9 v\u00e0 ph\u1ea1m vi h\u1ea5p th\u1ee5, ph\u00e2n b\u1ed1, chuy\u1ec3n h\u00f3a v\u00e0 ti\u1ebft ra kh\u1ecfi c\u01a1 th\u1ec3. \u0110i\u1ec1u n\u00e0y c\u00f3 th\u1ec3 d\u1eabn \u0111\u1ebfn s\u1ef1 thay \u0111\u1ed5i trong t\u00e1c d\u1ee5ng v\u00e0 t\u00e1c h\u1ea1i c\u1ee7a thu\u1ed1c, g\u00e2y ra c\u00e1c t\u00e1c d\u1ee5ng ph\u1ee5 v\u00e0 \u0111\u00f4i khi l\u00e0 nguy hi\u1ec3m cho b\u1ec7nh nh\u00e2n.<\/p>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Thu\u1ed1c \u0111\u01b0\u1ee3c \u0111\u01b0a v\u00e0o c\u01a1 th\u1ec3 b\u1eb1ng nhi\u1ec1u \u0111\u01b0\u1eddng. Sau khi \u0111\u01b0\u1ee3c h\u1ea5p thu \u0111\u1ec3 ph\u00e1t huy t\u00e1c d\u1ee5ng d\u01b0\u1ee3c l\u00fd, thu\u1ed1c \u0111\u01b0\u1ee3c coi l\u00e0 v\u1eadt l\u1ea1, c\u01a1 th\u1ec3 s\u1ebd t\u00ecm m\u1ecdi c\u00e1ch \u0111\u1ec3 th\u1ea3i tr\u1eeb. Trong m\u1ed7i giai \u0111o\u1ea1n trong c\u01a1 th\u1ec3 ng\u01b0\u1eddi, c\u00e1c thu\u1ed1c s\u1ebd g\u1eb7p nhau v\u00e0 t\u01b0\u01a1ng t\u00e1c l\u1eabn nhau, \u0111\u1ec3 [&hellip;]<\/p>\n","protected":false},"author":19,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[12,33],"tags":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v20.4 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>T\u01b0\u01a1ng t\u00e1c thu\u1ed1c do \u0111\u1ed1i kh\u00e1ng \u1ea3nh h\u01b0\u1edfng \u0111\u1ebfn d\u01b0\u1ee3c \u0111\u1ed9ng h\u1ecdc<\/title>\n<meta name=\"description\" content=\"T\u01b0\u01a1ng t\u00e1c thu\u1ed1c l\u00e0 hi\u1ec7n t\u01b0\u1ee3ng x\u1ea3y ra khi hai ho\u1eb7c nhi\u1ec1u lo\u1ea1i thu\u1ed1c \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng c\u00f9ng nhau v\u00e0 g\u00e2y ra t\u00e1c \u0111\u1ed9ng l\u00ean c\u01a1 th\u1ec3.\" \/>\n<meta name=\"robots\" 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