{"id":26862,"date":"2023-04-22T22:19:29","date_gmt":"2023-04-22T15:19:29","guid":{"rendered":"http:\/\/noithathoaphat.in\/ctv\/?p=26862"},"modified":"2023-04-22T22:19:29","modified_gmt":"2023-04-22T15:19:29","slug":"tong-quan-ve-thuoc-rhopressa-trong-dieu-tri-tang-nhan-ap","status":"publish","type":"post","link":"http:\/\/noithathoaphat.in\/ctv\/index.php\/2023\/04\/22\/tong-quan-ve-thuoc-rhopressa-trong-dieu-tri-tang-nhan-ap\/","title":{"rendered":"T\u1ed5ng quan v\u1ec1 thu\u1ed1c Rhopressa trong \u0111i\u1ec1u tr\u1ecb t\u0103ng nh\u00e3n \u00e1p"},"content":{"rendered":"

Rhopressa l\u00e0 m\u1ed9t lo\u1ea1i thu\u1ed1c \u1ee9c ch\u1ebf Rho kinase (ROCK) \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng \u0111\u1ec3 gi\u1ea3m t\u0103ng \u00e1p l\u1ef1c trong m\u1eaft v\u00e0 \u0111i\u1ec1u tr\u1ecb t\u0103ng nh\u00e3n \u00e1p. Thu\u1ed1c \u0111\u00e3 \u0111\u01b0\u1ee3c FDA ch\u1ea5p thu\u1eadn s\u1eed d\u1ee5ng v\u00e0 \u0111ang \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng \u0111\u1ec3 \u0111i\u1ec1u tr\u1ecb b\u1ec7nh t\u0103ng nh\u00e3n \u00e1p \u1edf m\u1ed9t s\u1ed1 n\u01b0\u1edbc tr\u00ean th\u1ebf gi\u1edbi. Rhopressa ho\u1ea1t \u0111\u1ed9ng t\u1ed1i \u01b0u gi\u00fap gi\u1ea3m \u00e1p l\u1ef1c trong m\u1eaft m\u1ed9t c\u00e1ch hi\u1ec7u qu\u1ea3. Thu\u1ed1c \u0111\u00e3 \u0111\u01b0\u1ee3c ki\u1ec3m tra v\u00e0 ch\u1ee9ng minh l\u00e0 an to\u00e0n v\u00e0 c\u00f3 hi\u1ec7u qu\u1ea3 trong c\u00e1c nghi\u00ean c\u1ee9u l\u00e2m s\u00e0ng<\/strong><\/p>\n

1.Gi\u1edbi thi\u1ec7u chung\u00a0<\/strong><\/h2>\n

\u00c1p l\u1ef1c n\u1ed9i nh\u00e3n (IOP)<\/a> \u0111\u01b0\u1ee3c \u0111\u1ecbnh ngh\u0129a l\u00e0 \u00e1p su\u1ea5t ch\u1ea5t l\u1ecfng c\u1ee7a m\u1eaft. V\u00ec \u00e1p su\u1ea5t l\u00e0 th\u01b0\u1edbc \u0111o l\u1ef1c tr\u00ean m\u1ed7i di\u1ec7n t\u00edch, n\u00ean IOP l\u00e0 ph\u00e9p \u0111o li\u00ean quan \u0111\u1ebfn \u0111\u1ed9 l\u1edbn c\u1ee7a l\u1ef1c do th\u1ee7y d\u1ecbch t\u00e1c d\u1ee5ng l\u00ean di\u1ec7n t\u00edch b\u1ec1 m\u1eb7t b\u00ean trong c\u1ee7a m\u1eaft tr\u01b0\u1edbc. \u00c1p l\u1ef1c n\u1ed9i nh\u00e3n \u0111\u01b0\u1ee3c \u0111i\u1ec1u ch\u1ec9nh c\u1ea9n th\u1eadn v\u00e0 c\u00e1c r\u1ed1i lo\u1ea1n th\u01b0\u1eddng li\u00ean quan \u0111\u1ebfn s\u1ef1 ph\u00e1t tri\u1ec3n c\u1ee7a c\u00e1c b\u1ec7nh l\u00fd nh\u01b0 t\u0103ng nh\u00e3n \u00e1p, vi\u00eam m\u00e0ng b\u1ed3 \u0111\u00e0o v\u00e0 bong v\u00f5ng m\u1ea1c. IOP t\u1ed3n t\u1ea1i nh\u01b0 m\u1ed9t tr\u1ea1ng th\u00e1i c\u00e2n b\u1eb1ng tinh ch\u1ec9nh gi\u1eefa s\u1ea3n xu\u1ea5t v\u00e0 ti\u00eau tho\u00e1t th\u1ee7y d\u1ecbch. S\u1ef1 c\u00e2n b\u1eb1ng gi\u1eefa IOP t\u0103ng l\u00ean khi huy\u1ebft \u00e1p h\u1ec7 th\u1ed1ng t\u0103ng l\u00ean, IOP t\u0103ng \u0111\u1ed9t ng\u1ed9t g\u00e2y ra c\u0103ng th\u1eb3ng c\u01a1 h\u1ecdc v\u00e0 t\u00e1c \u0111\u1ed9ng thi\u1ebfu m\u00e1u c\u1ee5c b\u1ed9 l\u00ean l\u1edbp s\u1ee3i th\u1ea7n kinh v\u00f5ng m\u1ea1c trong khi IOP gi\u1ea3m \u0111\u1ed9t ng\u1ed9t khi\u1ebfn c\u00e1c bong b\u00f3ng si\u00eau nh\u1ecf h\u00ecnh th\u00e0nh t\u1eeb c\u00e1c kh\u00ed h\u00f2a tan trong vi m\u1ea1ch d\u1eabn \u0111\u1ebfn t\u1eafc m\u1ea1ch kh\u00ed v\u00e0 t\u1ed5n th\u01b0\u01a1ng m\u00f4 do thi\u1ebfu m\u00e1u c\u1ee5c b\u1ed9<\/span><\/p>\n

\"\u00c1p
\u00c1p l\u1ef1c n\u1ed9i nh\u00e3n (IOP)<\/figcaption><\/figure>\n

Rhopressa l\u1ea7n \u0111\u1ea7u \u0111\u01b0\u1ee3c C\u1ee5c qu\u1ea3n l\u00fd Th\u1ef1c ph\u1ea9m v\u00e0 D\u01b0\u1ee3c ph\u1ea9m (FDA) ch\u1ea5p thu\u1eadn v\u00e0o n\u0103m 2017 l\u00e0 li\u1ec7u ph\u00e1p \u0111\u1ea7u tay l\u00e0m gi\u1ea3m \u00e1p l\u1ef1c n\u1ed9i nh\u00e3n (IOP) t\u0103ng cao. FDA \u0111\u00e3 ph\u00ea duy\u1ec7t Rhopressa d\u1ef1a tr\u00ean b\u1eb1ng ch\u1ee9ng t\u1eeb 3 th\u1eed nghi\u1ec7m l\u00e2m s\u00e0ng thu nh\u1eadn 1875 b\u1ec7nh nh\u00e2n m\u1eafc b\u1ec7nh t\u0103ng nh\u00e3n \u00e1p g\u00f3c m\u1edf ho\u1eb7c t\u0103ng nh\u00e3n \u00e1p \u0111\u01b0\u1ee3c ti\u1ebfn h\u00e0nh t\u1ea1i Hoa K\u1ef3. C\u00e1c th\u1eed nghi\u1ec7m ng\u1eabu nhi\u00ean m\u00f9 \u0111\u00f4i \u0111\u01b0\u1ee3c th\u1ef1c hi\u1ec7n \u0111\u1ec3 \u0111\u00e1nh gi\u00e1 hi\u1ec7u qu\u1ea3 v\u00e0 an to\u00e0n c\u1ee7a Rhopressa, m\u1ed7i b\u1ec7nh nh\u00e2n \u0111\u01b0\u1ee3c ch\u1ec9 \u0111\u1ecbnh ng\u1eabu nhi\u00ean \u0111\u1ec3 d\u00f9ng thu\u1ed1c nh\u1ecf m\u1eaft Rhopressa ho\u1eb7c Timolol. Sau k\u1ebft th\u00fac th\u1eed nghi\u1ec7m, Rhopressa cho k\u1ebft qu\u1ea3 t\u00e1c d\u1ee5ng gi\u1ea3m nh\u00e3n \u00e1p so v\u1edbi Timolol sau th\u1eddi gian 6 tu\u1ea7n 3 th\u00e1ng \u0111i\u1ec1u tr\u1ecb. Hi\u1ec7u qu\u1ea3 c\u1ee7a Rhopressa t\u01b0\u01a1ng t\u1ef1 nhau trong c\u00e1c nghi\u00ean c\u1ee9u l\u00e2m s\u00e0ng gi\u1eefa gi\u1edbi t\u00ednh, ch\u1ee7ng t\u1ed9c v\u00e0 tu\u1ed5i t\u00e1c<\/span><\/p>\n

2.Th\u00f4ng tin v\u1ec1 thu\u1ed1c Rhopressa<\/strong><\/h2>\n

2.1 Nh\u00f3m d\u01b0\u1ee3c l\u00fd v\u00e0 ch\u1ec9 \u0111\u1ecbnh s\u1eed d\u1ee5ng\u00a0<\/span><\/h3>\n

Rhopressa \u0111\u01b0\u1ee3c bi\u1ebft \u0111\u1ebfn v\u1edbi bi\u1ec7t d\u01b0\u1ee3c Netrasudil, thu\u1ed9c nh\u00f3m thu\u1ed1c ch\u1ed1ng t\u0103ng nh\u00e3n \u00e1p nh\u00e3n khoa. Rhopressa (d\u00e0nh cho m\u1eaft) \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng \u0111\u1ec3 \u0111i\u1ec1u tr\u1ecb b\u1ec7nh t\u0103ng nh\u00e3n \u00e1p g\u00f3c m\u1edf ho\u1eb7c c\u00e1c nguy\u00ean nh\u00e2n kh\u00e1c g\u00e2y \u00e1p l\u1ef1c cao b\u00ean trong m\u1eaft.\u00a0<\/span><\/p>\n

\"Netrasudil
Netrasudil (Rhopressa)<\/figcaption><\/figure>\n

D\u1ea1ng b\u00e0o ch\u1ebf thu\u1ed1c: d\u1ea1ng \u1ed1ng nh\u1ecf m\u1eaft 2,5ml v\u1edbi h\u00e0m l\u01b0\u1ee3ng ho\u1ea1t ch\u1ea5t 0,02%<\/span><\/p>\n

2.2 C\u01a1 ch\u1ebf ho\u1ea1t \u0111\u1ed9ng\u00a0<\/span><\/h3>\n

Rhopressa ho\u1ea1t \u0111\u1ed9ng b\u1eb1ng nh\u01b0 ch\u1ea5t \u1ee9c ch\u1ebf Rho kinase (ROCK) \u0111\u1ea7u ti\u00ean v\u1edbi ho\u1ea1t t\u00ednh \u1ee9c ch\u1ebf v\u1eadn chuy\u1ec3n Norepinephrine l\u00e0m gi\u1ea3m s\u1ea3n xu\u1ea5t th\u1ee7y d\u1ecbch. Ti\u1ebfn s\u0129 Aref cho bi\u1ebft Rhopressa s\u1edf h\u1eefu 3 c\u01a1 ch\u1ebf ho\u1ea1t \u0111\u1ed9ng kh\u00e1c nhau trong m\u1ed9t t\u00e1c nh\u00e2n duy nh\u1ea5t: (1) Gi\u1ea3m kh\u1ea3 n\u0103ng ch\u1ed1ng l\u1ea1i d\u00f2ng ch\u1ea3y ra ngo\u00e0i qua m\u1ea1ng l\u01b0\u1edbi trabecular (2) Gi\u1ea3m s\u1ea3n xu\u1ea5t ch\u1ea5t l\u1ecfng (3) Gi\u1ea3m \u00e1p l\u1ef1c t\u0129nh m\u1ea1ch th\u01b0\u1ee3ng b\u00ec. Ngo\u00e0i ra ti\u1ebfn s\u0129 Weinreb cho bi\u1ebft trong s\u1ed1 c\u00e1c t\u00e1c d\u1ee5ng c\u1ee7a n\u00f3, Rhopressa ho\u1ea1t \u0111\u1ed9ng \u1edf c\u1ea5p \u0111\u1ed9 t\u1ebf b\u00e0o trong m\u1ea1ng l\u01b0\u1edbi ph\u00e2n t\u1eed v\u1edbi c\u01a1 ch\u1ebf ho\u1ea1t \u0111\u1ed9ng ch\u00ednh l\u00e0m gi\u1ea3m co th\u1eaft c\u00e1c s\u1ee3i Actin v\u00e0 gi\u1ea3m s\u1ef1 k\u1ebft d\u00ednh khu tr\u00fa trong m\u1ea1ng l\u01b0\u1edbi ph\u00e2n t\u1eed \u0111\u1ec3 c\u1ea3i thi\u1ec7n d\u00f2ng ch\u1ea3y c\u1ee7a th\u1ee7y d\u1ecbch\u00a0<\/span><\/p>\n

2.3 D\u01b0\u1ee3c l\u1ef1c h\u1ecdc\u00a0<\/span><\/h3>\n

Th\u1ee7y d\u1ecbch ch\u1ea3y ra kh\u1ecfi m\u1eaft qua hai con \u0111\u01b0\u1eddng: (1) Con \u0111\u01b0\u1eddng ch\u1ee7 y\u1ebfu qua v\u00f9ng b\u00e8 v\u00e0 \u1ed1ng Schlemm (2) M\u1ed9t l\u01b0\u1ee3ng nh\u1ecf h\u01a1n ch\u1ea3y qua b\u1ec1 m\u1eb7t c\u01a1 th\u1ec3 mi v\u00e0o m\u00e0ng b\u1ed3 \u0111\u00e0o. M\u1eb7c d\u00f9 ng\u01b0\u1eddi ta \u0111\u00e3 ch\u1ee9ng minh r\u1eb1ng con \u0111\u01b0\u1eddng v\u00f9ng b\u00e8 th\u00f4ng th\u01b0\u1eddng chi\u1ebfm ph\u1ea7n l\u1edbn l\u01b0\u1ee3ng n\u01b0\u1edbc ch\u1ea3y ra do c\u00e1c b\u1ec7nh l\u00fd kh\u00e1c nhau nh\u01b0ng h\u1ea7u h\u1ebft c\u00e1c lo\u1ea1i thu\u1ed1c c\u00f3 s\u1eb5n \u0111\u1ec3 \u0111i\u1ec1u tr\u1ecb b\u1ec7nh t\u0103ng nh\u00e3n \u00e1p \u0111\u1ec1u nh\u1eafm v\u00e0o con \u0111\u01b0\u1eddng con \u0111\u01b0\u1eddng m\u00e0ng b\u1ed3 \u0111\u00e0o. Trong khi \u0111\u00f3 Rhopressa l\u00e0 lo\u1ea1i thu\u1ed1c tr\u1ecb t\u0103ng nh\u00e3n \u00e1p ho\u1ea1t \u0111\u1ed9ng nh\u01b0 ch\u1ea5t \u1ee9c \u1ee9c ch\u1ebf v\u1eadn chuy\u1ec3n Rho kinase v\u00e0 Norepinephrine (NET) \u0111\u01b0\u1ee3c t\u00ecm th\u1ea5y trong con \u0111\u01b0\u1eddng v\u00f9ng b\u00e8 (trabecular) th\u00f4ng th\u01b0\u1eddng. \u1ede m\u1eaft b\u1ecb t\u0103ng nh\u00e3n \u00e1p, IOP t\u0103ng cao l\u00e0 k\u1ebft qu\u1ea3 c\u1ee7a s\u1ef1 gia t\u0103ng b\u1ea5t th\u01b0\u1eddng kh\u1ea3 n\u0103ng ch\u1ed1ng l\u1ea1i d\u00f2ng n\u01b0\u1edbc ch\u1ea3y ra trong con \u0111\u01b0\u1eddng v\u00f9ng b\u00e8 th\u00f4ng th\u01b0\u1eddng do s\u1ef1 gia t\u0103ng r\u00f5 r\u1ec7t c\u1ee7a tr\u01b0\u01a1ng l\u1ef1c co b\u00f3p v\u00e0 \u0111\u1ed9 c\u1ee9ng c\u1ee7a m\u1ea1ng l\u01b0\u1edbi \u0111\u01b0\u1eddng ph\u00e2n t\u1eed (TM), thay \u0111\u1ed5i th\u00e0nh ph\u1ea7n ma tr\u1eadn ngo\u1ea1i b\u00e0o v\u00e0\/ho\u1eb7c gi\u1ea3m \u0111\u1ed9 d\u1eabn c\u1ee7a c\u00e1c t\u1ebf b\u00e0o n\u1ed9i m\u00f4 (IW) c\u1ee7a \u1ed1ng Schlemm (SC). V\u00ec v\u1eady, t\u00ednh m\u1edbi c\u1ee7a Rhopressa n\u1eb1m \u1edf kh\u1ea3 n\u0103ng ho\u1eb7c t\u00ednh \u0111\u1eb7c hi\u1ec7u c\u1ee7a n\u00f3 trong vi\u1ec7c \u00e1p d\u1ee5ng c\u01a1 ch\u1ebf ho\u1ea1t \u0111\u1ed9ng c\u1ee7a n\u00f3 m\u1ed9t c\u00e1ch tr\u1ef1c ti\u1ebfp v\u00e0 c\u1ee5 th\u1ec3 t\u1ea1i con \u0111\u01b0\u1eddng v\u00f9ng b\u00e8 th\u00f4ng th\u01b0\u1eddng. C\u1ee5 th\u1ec3, Rho kinase c\u00f3 vai tr\u00f2 l\u00e0 c\u00e1c t\u00e1c nh\u00e2n quan tr\u1ecdng c\u1ee7a Rho GTPase ho\u1ea1t \u0111\u1ed9ng trong v\u00f9ng b\u00e8 v\u00e0 \u1ed1ng Schlemm th\u00fac \u0111\u1ea9y s\u1ef1 co r\u00fat Actomyosin, th\u00fac \u0111\u1ea9y s\u1ea3n xu\u1ea5t ma tr\u1eadn ngo\u1ea1i b\u00e0o v\u00e0 t\u0103ng \u0111\u1ed9 c\u1ee9ng c\u1ee7a t\u1ebf b\u00e0o. Khi \u0111\u00f3 Rhopress \u1ee9c ch\u1ebf Rho kinase l\u00e0m gi\u1ea3m s\u1ef1 co l\u1ea1i c\u1ee7a t\u1ebf b\u00e0o, gi\u1ea3m bi\u1ec3u hi\u1ec7n c\u1ee7a c\u00e1c protein li\u00ean quan \u0111\u1ebfn x\u01a1 h\u00f3a v\u00e0 gi\u1ea3m \u0111\u1ed9 c\u1ee9ng c\u1ee7a t\u1ebf b\u00e0o trong v\u00f9ng b\u00e8 v\u00e0 \u1ed1ng Schlemm. Ngo\u00e0i ra, Rhopressa \u0111\u01b0\u1ee3c ch\u1ee9ng minh l\u00e0 c\u00f3 t\u00e1c d\u1ee5ng \u1ee9c ch\u1ebf ch\u1ea5t v\u1eadn chuy\u1ec3n Norepinephrine (NET) gi\u00fap ng\u0103n ch\u1eb7n s\u1ef1 t\u00e1i h\u1ea5p thu Norepinephrine \u1edf c\u00e1c kh\u1edbp th\u1ea7n kinh Noradrenergic d\u1eabn \u0111\u1ebfn t\u0103ng c\u01b0\u1eddng m\u1ee9c \u0111\u1ed9 v\u00e0 th\u1eddi gian truy\u1ec1n t\u00edn hi\u1ec7u Norepinephrine n\u1ed9i sinh. K\u1ebft qu\u1ea3 c\u1ee7a vi\u1ec7c truy\u1ec1n t\u00edn hi\u1ec7u \u0111\u01b0\u1ee3c t\u0103ng c\u01b0\u1eddng n\u00e0y l\u00e0 s\u1ef1 co m\u1ea1ch l\u00e0m gi\u1ea3m l\u01b0u l\u01b0\u1ee3ng m\u00e1u \u0111\u1ebfn th\u1ec3 mi.<\/span><\/p>\n

2.4 D\u01b0\u1ee3c \u0111\u1ed9ng h\u1ecdc<\/span><\/h3>\n

H\u1ea5p thu: N\u1ed3ng \u0111\u1ed9 thu\u1ed1c trong huy\u1ebft t\u01b0\u01a1ng \u1edf 0,11 ng\/mL \u0111\u1ed1i v\u1edbi ch\u1ea5t chuy\u1ec3n h\u00f3a c\u00f3 ho\u1ea1t t\u00ednh sau khi s\u1eed d\u1ee5ng v\u00e0o ng\u00e0y th\u1ee9 8\u00a0<\/span><\/p>\n

Ph\u00e2n b\u1ed1: V\u00ec Rhopressa v\u00e0 ch\u1ea5t chuy\u1ec3n h\u00f3a c\u00f3 ho\u1ea1t t\u00ednh th\u1ec3 hi\u1ec7n m\u1ee9c \u0111\u1ed9 g\u1eafn k\u1ebft cao v\u1edbi protein n\u00ean th\u1ec3 t\u00edch ph\u00e2n b\u1ed1 (Vd) th\u1ea5p. Ch\u1ea5t chuy\u1ec3n h\u00f3a c\u00f3 ho\u1ea1t t\u00ednh c\u1ee7a Rhopressa c\u00f3 kh\u1ea3 n\u0103ng li\u00ean k\u1ebft v\u1edbi protein cao trong huy\u1ebft t\u01b0\u01a1ng kho\u1ea3ng 60%<\/span><\/p>\n

Chuy\u1ec3n h\u00f3a: Rhopressa \u0111\u01b0\u1ee3c chuy\u1ec3n h\u00f3a b\u1edfi c\u00e1c Esterase\u00a0<\/span><\/p>\n

Th\u1ea3i tr\u1eeb: Rhopressa \u0111\u01b0\u1ee3c chuy\u1ec3n h\u00f3a qua h\u1ec7 microsome trong gan v\u1edbi <\/span>th\u1eddi gian b\u00e1n h\u1ee7y (T1\/2) l\u00e0 175 ph\u00fat\u00a0<\/span><\/p>\n

2.5 T\u00e1c d\u1ee5ng ph\u1ee5\u00a0<\/span><\/h3>\n

C\u00e1c t\u00e1c d\u1ee5ng ph\u1ee5 ph\u1ed5 bi\u1ebfn th\u01b0\u1eddng g\u1eb7p khi s\u1eed d\u1ee5ng Rhpressa bao g\u1ed3m: \u0111\u1ecf m\u1eaft, b\u1ea5t th\u01b0\u1eddng gi\u00e1c m\u1ea1c, \u0111au, v\u1ee1 m\u1ea1ch m\u00e1u m\u1eaft<\/span><\/p>\n

2.6 Li\u1ec1u d\u00f9ng\u00a0<\/span><\/h3>\n

Li\u1ec1u Rhopressa \u0111\u01b0\u1ee3c khuy\u1ebfn c\u00e1o l\u00e0 nh\u1ecf 1 gi\u1ecdt v\u00e0o c\u00e1c m\u1eaft b\u1ecb t\u1ed5n th\u01b0\u01a1ng 1 l\u1ea7n m\u1ed7i ng\u00e0y v\u00e0o bu\u1ed5i t\u1ed1i<\/span><\/p>\n

3.\u01afu v\u00e0 nh\u01b0\u1ee3c \u0111i\u1ec3m c\u1ee7a thu\u1ed1c Rhopressa<\/strong><\/h2>\n

3.1 \u01afu \u0111i\u1ec3m\u00a0<\/span><\/h3>\n

C\u01a1 ch\u1ebf ho\u1ea1t \u0111\u1ed9ng kh\u00e1c v\u1edbi c\u00e1c thu\u1ed1c nh\u00e3n khoa \u0111i\u1ec1u tr\u1ecb t\u0103ng nh\u00e3n \u00e1p kh\u00e1c n\u00ean c\u00f3 th\u1ec3 \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng v\u1edbi c\u00e1c lo\u1ea1i thu\u1ed1c h\u1ea1 nh\u00e3n \u00e1p kh\u00e1c<\/span><\/p>\n

Kh\u00f4ng g\u00e2y th\u00e2m qu\u1ea7ng m\u1eaft nh\u01b0 c\u00e1c lo\u1ea1i thu\u1ed1c nh\u1ecf m\u1eaft kh\u00e1c<\/span><\/p>\n

Ch\u1ec9 c\u1ea7n s\u1eed d\u1ee5ng 1 l\u1ea7n v\u00e0o bu\u1ed5i t\u1ed1i<\/span><\/p>\n

3.2 Nh\u01b0\u1ee3c \u0111i\u1ec3m\u00a0<\/span><\/h3>\n

Gi\u00e1 th\u00e0nh cao<\/span><\/p>\n

T\u00e1c d\u1ee5ng ph\u1ee5 ph\u1ed5 bi\u1ebfn d\u1ec5 x\u1ea3y ra l\u00e0 \u0111\u1ecf m\u1eaft<\/span><\/p>\n

D\u1ec5 nhi\u1ec5m vi khu\u1ea9n\u00a0<\/span><\/p>\n

4.K\u1ebft lu\u1eadn <\/strong><\/h2>\n

Rhopressa (Netarsudil) l\u00e0 thu\u1ed1c nh\u1ecf m\u1eaft v\u1eeba hi\u1ec7u qu\u1ea3 v\u00e0 thu\u1eadn ti\u1ec7n trong \u0111i\u1ec1u tr\u1ecb t\u0103ng nh\u00e3n \u00e1p. \u0110\u00f3 l\u00e0 m\u1ed9t l\u1ef1a ch\u1ecdn thu\u1ed1c m\u1edbi h\u01a1n v\u00e0 duy nh\u1ea5t ho\u1ea1t \u0111\u1ed9ng nh\u1eafm v\u00e0o m\u1ee5c ti\u00eau con \u0111\u01b0\u1eddng v\u00f9ng b\u00e8 \u0111\u1ec3 l\u00e0m gi\u1ea3m nh\u00e3n \u00e1p.<\/p>\n","protected":false},"excerpt":{"rendered":"

Rhopressa l\u00e0 m\u1ed9t lo\u1ea1i thu\u1ed1c \u1ee9c ch\u1ebf Rho kinase (ROCK) \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng \u0111\u1ec3 gi\u1ea3m t\u0103ng \u00e1p l\u1ef1c trong m\u1eaft v\u00e0 \u0111i\u1ec1u tr\u1ecb t\u0103ng nh\u00e3n \u00e1p. Thu\u1ed1c \u0111\u00e3 \u0111\u01b0\u1ee3c FDA ch\u1ea5p thu\u1eadn s\u1eed d\u1ee5ng v\u00e0 \u0111ang \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng \u0111\u1ec3 \u0111i\u1ec1u tr\u1ecb b\u1ec7nh t\u0103ng nh\u00e3n \u00e1p \u1edf m\u1ed9t s\u1ed1 n\u01b0\u1edbc tr\u00ean th\u1ebf gi\u1edbi. Rhopressa ho\u1ea1t […]<\/p>\n","protected":false},"author":54,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[12],"tags":[],"yoast_head":"\nT\u1ed5ng quan v\u1ec1 thu\u1ed1c Rhopressa trong \u0111i\u1ec1u tr\u1ecb t\u0103ng nh\u00e3n \u00e1p<\/title>\n<meta name=\"description\" content=\"Rhopressa l\u00e0 m\u1ed9t lo\u1ea1i thu\u1ed1c \u1ee9c ch\u1ebf Rho kinase (ROCK) \u0111\u01b0\u1ee3c ch\u1ee9ng minh hi\u1ec7u qu\u1ea3 trong \u0111i\u1ec1u tr\u1ecb t\u0103ng nh\u00e3n \u00e1p qua nhi\u1ec1u th\u1eed nghi\u1ec7m\" \/>\n<meta name=\"robots\" content=\"noindex, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"T\u1ed5ng quan v\u1ec1 thu\u1ed1c Rhopressa trong \u0111i\u1ec1u tr\u1ecb t\u0103ng nh\u00e3n \u00e1p\" \/>\n<meta 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