{"id":26778,"date":"2023-04-27T15:43:41","date_gmt":"2023-04-27T08:43:41","guid":{"rendered":"http:\/\/noithathoaphat.in\/ctv\/?p=26778"},"modified":"2023-04-27T15:43:41","modified_gmt":"2023-04-27T08:43:41","slug":"mien-dich","status":"publish","type":"post","link":"http:\/\/noithathoaphat.in\/ctv\/index.php\/2023\/04\/27\/mien-dich\/","title":{"rendered":"Vai tr\u00f2 c\u1ee7a h\u1ec7 mi\u1ec5n d\u1ecbch \u1edf tr\u1ebb em b\u1ecb COVID 19"},"content":{"rendered":"

H\u1ec7 mi\u1ec5n d\u1ecbch l\u00e0 m\u1ed9t ph\u1ea7n r\u1ea5t quan tr\u1ecdng trong vi\u1ec7c b\u1ea3o v\u1ec7 c\u01a1 th\u1ec3 kh\u1ecfi c\u00e1c t\u00e1c nh\u00e2n g\u00e2y b\u1ec7nh nh\u01b0 virus v\u00e0 vi khu\u1ea9n. V\u1edbi s\u1ef1 b\u00f9ng ph\u00e1t c\u1ee7a \u0111\u1ea1i d\u1ecbch COVID-19, vai tr\u00f2 c\u1ee7a h\u1ec7 mi\u1ec5n d\u1ecbch \u1edf tr\u1ebb em b\u1ecb COVID-19 \u0111\u00e3 \u0111\u01b0\u1ee3c nghi\u00ean c\u1ee9u r\u1ed9ng r\u00e3i.<\/strong><\/p>\n

1. T\u1ed5ng quan<\/strong><\/h1>\n

Ch\u00fang ta bi\u1ebft r\u1eb1ng ph\u1ea3n \u1ee9ng vi\u00eam \u1edf tr\u1ebb em kh\u00e1c v\u1edbi ng\u01b0\u1eddi l\u1edbn. Nh\u01b0 v\u1eady c\u00e1c cytokine ti\u1ec1n vi\u00eam t\u0103ng theo tu\u1ed5i, do \u0111\u00f3 ch\u1ee9c n\u0103ng b\u1ea1ch c\u1ea7u trung t\u00ednh thay \u0111\u1ed5i theo tu\u1ed5i. T\u01b0\u01a1ng t\u1ef1, m\u1ee9c \u0111\u1ed9 myeloperoxidase, interleukin (IL)-6, IL-10 v\u00e0 p-selectin c\u0169ng t\u0103ng theo \u0111\u1ed9 tu\u1ed5i. V\u00ec b\u1ec7nh COVID-19 nghi\u00eam tr\u1ecdng \u0111\u01b0\u1ee3c \u0111\u1eb7c tr\u01b0ng b\u1edfi c\u01a1n b\u00e3o cytokine ho\u1eb7c ph\u1ea3n \u1ee9ng ti\u1ec1n vi\u00eam \u0111\u00e1ng k\u1ec3, do \u0111\u00f3 nguy c\u01a1 ph\u00e1t tri\u1ec3n ARDS v\u00e0 r\u1ed1i lo\u1ea1n ch\u1ee9c n\u0103ng \u0111a c\u01a1 quan t\u0103ng l\u00ean.<\/p>\n

Tuy nhi\u00ean, trong m\u1ed9t s\u1ed1 tr\u01b0\u1eddng h\u1ee3p, bi\u1ec3u hi\u1ec7n cytokine kh\u00f4ng t\u0103ng trong c\u00e1c t\u1ebf b\u00e0o mi\u1ec5n d\u1ecbch trong m\u00e1u ngo\u1ea1i vi, tuy nhi\u00ean, interferon lo\u1ea1i I – \u00a0l\u00e0 ch\u1ea5t c\u1ea3m \u1ee9ng r\u1ea5t m\u1ea1nh, cho th\u1ea5y s\u1ef1 hi\u1ec7n di\u1ec7n c\u1ee7a m\u1ed9t ngu\u1ed3n thay th\u1ebf kh\u00e1c ngo\u00e0i c\u00e1c cytokine g\u00e2y vi\u00eam.<\/p>\n

C\u00e1c cytokine ti\u1ec1n vi\u00eam li\u00ean quan \u0111\u1ebfn SARS-CoV-2 bao g\u1ed3m interferon (IFN)-\u03b3, TNF-\u03b1, y\u1ebfu t\u1ed1 t\u0103ng tr\u01b0\u1edfng n\u1ed9i m\u00f4 m\u1ea1ch m\u00e1u, protein h\u00f3a h\u01b0\u1edbng \u0111\u1ed9ng \u0111\u01a1n b\u00e0o (MCP)-1\/C-C ph\u1ed1i t\u1eed chemokine (CCL)-2, IL (IL-1R\u03b1 , IL-1\u03b2, IL-7, IL-8 v\u00e0 IL-10), y\u1ebfu t\u1ed1 k\u00edch th\u00edch d\u00f2ng b\u1ea1ch c\u1ea7u h\u1ea1t (G-CSF), y\u1ebfu t\u1ed1 t\u0103ng tr\u01b0\u1edfng nguy\u00ean b\u00e0o s\u1ee3i c\u01a1 b\u1ea3n, \u0111\u1ea1i th\u1ef1c b\u00e0o-b\u1ea1ch c\u1ea7u h\u1ea1t (GM)-CSF, protein c\u1ea3m \u1ee9ng (IP)- 10\/CXCL10, protein g\u00e2y vi\u00eam \u0111\u1ea1i th\u1ef1c b\u00e0o (MIP)-1\u03b1\/CCL3, MIP-1\u03b2\/CCL4 v\u00e0 y\u1ebfu t\u1ed1 t\u0103ng tr\u01b0\u1edfng c\u00f3 ngu\u1ed3n g\u1ed1c t\u1eeb ti\u1ec3u c\u1ea7u.<\/p>\n

Trong qu\u00e1 tr\u00ecnh nh\u00e2n l\u00ean c\u1ee7a virus, SARS-CoV-2 g\u00e2y ch\u1ebft c\u00e1c t\u1ebf b\u00e0o b\u1ecb nhi\u1ec5m b\u1ec7nh, l\u00e0m t\u0103ng qu\u00e1 tr\u00ecnh \u0111\u1ed1t ch\u00e1y t\u1ebf b\u00e0o bi\u1ec3u m\u00f4, IL-1R g\u00e2y ra s\u1ef1 b\u00e0i ti\u1ebft c\u00e1c cytokine ti\u1ec1n vi\u00eam (IL-6, IFN-\u03b3, MCP-1\/CCL2, MIP-1\u03b1\/CCL3, MIP-1\u03b2\/CCL4 v\u00e0 IP-10\/CXCL), t\u1eeb \u0111\u00f3 thu h\u00fat c\u00e1c t\u1ebf b\u00e0o T v\u00e0 \u0111\u1ea1i th\u1ef1c b\u00e0o \u0111\u01b0\u1ee3c k\u00edch ho\u1ea1t \u0111\u1ebfn v\u1ecb tr\u00ed nhi\u1ec5m tr\u00f9ng. C\u00e1c cytokine n\u00e0y g\u00e2y vi\u00eam v\u00e0 ph\u00e1 h\u1ee7y nhu m\u00f4 ph\u1ed5i. H\u01a1n n\u1eefa, t\u00edn hi\u1ec7u IFN b\u1ecb \u0111i\u1ec1u h\u00f2a \u1ea3nh h\u01b0\u1edfng \u0111\u1ebfn b\u1ec7nh l\u00fd mi\u1ec5n d\u1ecbch, d\u1eabn \u0111\u1ebfn suy gi\u1ea3m kh\u1ea3 n\u0103ng thanh th\u1ea3i virus kh\u1ecfi c\u00e1c t\u1ebf b\u00e0o b\u1ecb nhi\u1ec5m. Nhi\u1ec5m SARS-CoV-2 g\u00e2y ra ph\u1ea3n \u1ee9ng c\u1ee7a t\u1ebf b\u00e0o T CD4 v\u00e0 CD8 v\u00e0 t\u1ea1o ra c\u00e1c kh\u00e1ng th\u1ec3 \u0111\u1eb7c hi\u1ec7u v\u1edbi virus. B\u1ec7nh nh\u00e2n m\u1eafc ARDS bi\u1ec3u hi\u1ec7n t\u0103ng nguy\u00ean b\u00e0o plasma v\u00e0 t\u1ebf b\u00e0o Natural Kill (NK), t\u1ebf b\u00e0o \u0111u\u00f4i gai v\u00e0 t\u1ebf b\u00e0o \u0111\u01a1n nh\u00e2n CD16+ th\u00ec \u0111\u00e3 c\u1ea1n ki\u1ec7t.<\/p>\n

\"\"
Ngu\u1ed3n: Suliman Khan, Rabeea Siddique, Xiao Hao, Yueting Lin, Yuxin Liu, Xiaoyan Wang, Linlin Hua, and Ghulam Nabi, \u201cThe COVID-19 infection in children and its association with the immune system, prenatal stress, and neurological complications\u201d<\/strong>, International Journal of Biological Sciences,<\/em> 2022.<\/figcaption><\/figure>\n

2. C\u00e1c t\u1ebf b\u00e0o tham gia v\u00e0o h\u1ec7 mi\u1ec5n d\u1ecbch<\/strong><\/h2>\n

2.1. \u0110\u1ea1i th\u1ef1c b\u00e0o trong \u0111\u00e1p \u1ee9ng mi\u1ec5n d\u1ecbch<\/strong><\/h3>\n
    \n
  • C\u00e1c \u0111\u1ea1i th\u1ef1c b\u00e0o li\u00ean quan \u0111\u1ebfn COVID-19, ch\u1ee7 y\u1ebfu c\u00f3 ngu\u1ed3n g\u1ed1c t\u1eeb b\u1ea1ch c\u1ea7u \u0111\u01a1n nh\u00e2n g\u00e2y vi\u00eam, bi\u1ec3u hi\u1ec7n FABP4, ficolin-1 (FCN1) v\u00e0 SPP1 t\u01b0\u01a1ng \u1ee9ng trong tr\u01b0\u1eddng h\u1ee3p b\u1ec7nh nh\u1eb9 v\u00e0 n\u1eb7ng.<\/li>\n
  • C\u00e1c gen \u0111\u01b0\u1ee3c bi\u1ec3u hi\u1ec7n b\u1edfi c\u00e1c \u0111\u1ea1i th\u1ef1c b\u00e0o n\u00e0y m\u00e3 h\u00f3a c\u00e1c d\u1ea5u hi\u1ec7u gi\u1ed1ng nh\u01b0 b\u1ea1ch c\u1ea7u \u0111\u01a1n nh\u00e2n ngo\u1ea1i vi, chemokine v\u00e0 c\u00e1c y\u1ebfu t\u1ed1 phi\u00ean m\u00e3 g\u00e2y vi\u00eam.<\/li>\n
  • Ngo\u00e0i ra, trong tr\u01b0\u1eddng h\u1ee3p COVID-19 nghi\u00eam tr\u1ecdng, c\u00e1c \u0111\u1ea1i th\u1ef1c b\u00e0o M2 thay th\u1ebf \u0111\u00e3 \u0111\u01b0\u1ee3c b\u00e1o c\u00e1o c\u00f3 bi\u1ec3u hi\u1ec7n TREM2, TGFB1 v\u00e0 SPP1, l\u00e0 c\u00e1c gen ch\u1ee9c n\u0103ng v\u00e0 gen \u0111i\u1ec1u h\u00f2a mi\u1ec5n d\u1ecbch bao g\u1ed3m A2M v\u00e0 GPR3. Nh\u1eefng d\u1ea5u hi\u1ec7u n\u00e0y cho th\u1ea5y \u0111\u1ea1i th\u1ef1c b\u00e0o kh\u00f4ng ch\u1ec9 li\u00ean quan \u0111\u1ebfn vi\u00eam nhi\u1ec5m m\u00e0 c\u00f2n li\u00ean quan \u0111\u1ebfn x\u01a1 h\u00f3a ph\u1ed5i.<\/li>\n<\/ul>\n

    2.2. T\u1ebf b\u00e0o Natural Kill<\/strong><\/h3>\n
      \n
    • COVID-19 n\u1eb7ng l\u00e0m c\u1ea1n ki\u1ec7t c\u00e1c t\u1ebf b\u00e0o Natural Kill. C\u00e1c t\u1ebf b\u00e0o Natural Kill b\u1ecb c\u1ea1n ki\u1ec7t nhi\u1ec1u \u1edf b\u1ec7nh nh\u00e2n COVID-19 m\u1eafc b\u1ec7nh n\u1eb7ng so v\u1edbi nh\u1eefng ng\u01b0\u1eddi m\u1eafc b\u1ec7nh nh\u1eb9. Nh\u1eefng b\u1ec7nh nh\u00e2n ph\u1ee5 thu\u1ed9c v\u00e0o m\u00e1y th\u1edf bi\u1ec3u hi\u1ec7n s\u1ef1 suy gi\u1ea3m CD56dim NK 43 g\u00e2y \u0111\u1ed9c t\u1ebf b\u00e0o kh\u00e1ng virus.<\/li>\n
    • Ng\u01b0\u1eddi ta kh\u00f4ng bi\u1ebft s\u1ef1 suy gi\u1ea3m c\u1ee7a c\u00e1c t\u1ebf b\u00e0o Natural Kill x\u1ea3y ra nh\u01b0 th\u1ebf n\u00e0o; tuy nhi\u00ean, \u0111\u00f3 c\u00f3 th\u1ec3 l\u00e0 do t\u1ebf b\u00e0o ch\u1ebft ho\u1eb7c s\u1ef1 di chuy\u1ec3n c\u1ee7a c\u00e1c t\u1ebf b\u00e0o \u0111\u1ebfn m\u00f4 ph\u1ed5i b\u1ecb nhi\u1ec5m b\u1ec7nh, \u0111i\u1ec1u n\u00e0y c\u0169ng \u0111\u01b0\u1ee3c k\u00edch th\u00edch b\u1edfi s\u1ef1 m\u1edf r\u1ed9ng c\u1ee7a c\u00e1c \u0111\u1ea1i th\u1ef1c b\u00e0o ph\u1ed5i. V\u00ec COVID-19 d\u1eabn \u0111\u1ebfn s\u1ef1 \u0111i\u1ec1u h\u00f2a l\u1ea1i c\u1ee7a qu\u00e1 tr\u00ecnh sao ch\u00e9p TP53 v\u00e0 qu\u00e1 tr\u00ecnh t\u1ef1 h\u1ee7y, do \u0111\u00f3, t\u1ebf b\u00e0o ch\u1ebft c\u0169ng c\u00f3 th\u1ec3 g\u00f3p ph\u1ea7n l\u00e0m c\u1ea1n ki\u1ec7t c\u00e1c t\u1ebf b\u00e0o Natural Kill. Nh\u1eefng \u0111i\u1ec1u n\u00e0y cho th\u1ea5y \u0111\u1ea1i th\u1ef1c b\u00e0o ho\u1eb7c cytokine c\u00f3 th\u1ec3 l\u00e0m trung gian cho s\u1ef1 r\u1ed1i lo\u1ea1n ch\u1ee9c n\u0103ng c\u1ee7a c\u00e1c t\u1ebf b\u00e0o Natural Kill trong COVID-19.<\/li>\n<\/ul>\n

      2.3. T\u1ebf b\u00e0o T\u00a0<\/strong><\/h3>\n
        \n
      • Gi\u1ea3m b\u1ea1ch c\u1ea7u l\u00e0 m\u1ed9t \u0111\u1eb7c \u0111i\u1ec3m ph\u1ed5 bi\u1ebfn c\u1ee7a COVID-19, c\u00f3 th\u1ec3 \u0111\u1ea3o ng\u01b0\u1ee3c t\u00ecnh tr\u1ea1ng n\u00e0y b\u1eb1ng c\u00e1ch c\u1ea3i thi\u1ec7n m\u1ee9c \u0111\u1ed9 cytokine.<\/li>\n
      • S\u1ed1 l\u01b0\u1ee3ng t\u1ebf b\u00e0o lympho \u0111\u00e3 ti\u1ebft l\u1ed9 r\u1eb1ng c\u00e1c t\u1ebf b\u00e0o T CD4+ v\u00e0 CD8+ gi\u1ea3m \u0111\u00e1ng k\u1ec3 trong c\u1ea3 COVID-19. \u0110\u01b0\u1ee3c bi\u1ebft, c\u00f3 m\u1ed9t m\u1ed1i t\u01b0\u01a1ng quan ngh\u1ecbch gi\u1eefa n\u1ed3ng \u0111\u1ed9 cytokine huy\u1ebft thanh v\u00e0 s\u1ed1 l\u01b0\u1ee3ng t\u1ebf b\u00e0o T. C\u00e1c t\u1ebf b\u00e0o T c\u0169ng c\u00f3 th\u1ec3 l\u00e0m tr\u1ea7m tr\u1ecdng th\u00eam t\u00ecnh tr\u1ea1ng t\u0103ng vi\u00eam v\u00ec c\u00e1c b\u1ec7nh nh\u00e2n COVID-19 \u0111\u00e3 \u0111\u01b0\u1ee3c b\u00e1o c\u00e1o c\u00f3 c\u00e1c t\u1ebf b\u00e0o Th1 CD4+ T g\u00e2y b\u1ec7nh gia t\u0103ng, bi\u1ec3u hi\u1ec7n IFN-\u03b3, IL-6 v\u00e0 GM-CSF 44.<\/li>\n
      • C\u00e1c t\u1ebf b\u00e0o Th1 n\u00e0y t\u1ea1o ra c\u00e1c cytokine ti\u1ec1n vi\u00eam, \u0111\u00f3ng vai tr\u00f2 quan tr\u1ecdng trong c\u01a1n b\u00e3o cytokine v\u00e0 l\u00e0m t\u1ed5n th\u01b0\u01a1ng m\u00f4 ph\u1ed5i. C\u00e1c t\u1ebf b\u00e0o \u0111i\u1ec1u h\u00f2a T l\u00e0 nh\u00e2n t\u1ed1 ch\u00ednh trong c\u00e2n b\u1eb1ng n\u1ed9i m\u00f4i mi\u1ec5n d\u1ecbch; do \u0111\u00f3, s\u1ef1 r\u1ed1i lo\u1ea1n \u0111i\u1ec1u h\u00f2a c\u1ee7a ch\u00fang c\u00f3 th\u1ec3 l\u00e0m gi\u1ea3m kh\u1ea3 n\u0103ng \u0111i\u1ec1u h\u00f2a mi\u1ec5n d\u1ecbch.<\/li>\n<\/ul>\n

        2.4. B\u1ea1ch c\u1ea7u trung t\u00ednh <\/strong><\/h3>\n
          \n
        • S\u1ed1 l\u01b0\u1ee3ng b\u1ea1ch c\u1ea7u trung t\u00ednh t\u0103ng cao l\u00e0 d\u1ea5u hi\u1ec7u ti\u00ean l\u01b0\u1ee3ng c\u1ee7a ARDS v\u00e0 t\u1eed vong do COVID g\u00e2y ra. Trong c\u00e1c tr\u01b0\u1eddng h\u1ee3p n\u1eb7ng c\u1ee7a COVID-19, m\u1ee9c b\u1eaby ngo\u1ea1i b\u00e0o b\u1ea1ch c\u1ea7u trung t\u00ednh (NET) t\u0103ng l\u00ean. NET l\u00e0 m\u1ea1ng l\u01b0\u1edbi v\u1eadt li\u1ec7u DNA v\u1edbi c\u00e1c enzym oxy h\u00f3a \u0111\u01b0\u1ee3c t\u1ea1o ra b\u1edfi b\u1ea1ch c\u1ea7u trung t\u00ednh v\u00e0 ch\u1ea5t ch\u1ed1ng vi tr\u00f9ng \u0111\u1ec3 ki\u1ec3m so\u00e1t nhi\u1ec5m tr\u00f9ng. NET c\u00f3 th\u1ec3 g\u00e2y t\u1ed5n th\u01b0\u01a1ng ph\u1ed5i v\u00e0 huy\u1ebft kh\u1ed1i mi\u1ec5n d\u1ecbch \u1edf b\u1ec7nh nh\u00e2n m\u1eafc COVID-19.<\/li>\n
        • C\u00e1c nghi\u00ean c\u1ee9u tr\u01b0\u1edbc \u0111\u00e2y d\u1ef1a tr\u00ean ph\u01b0\u01a1ng ph\u00e1p mi\u1ec5n d\u1ecbch hu\u1ef3nh quang \u0111\u00e3 b\u00e1o c\u00e1o r\u1eb1ng b\u1ea1ch c\u1ea7u trung t\u00ednh th\u00e2m nhi\u1ec5m v\u1edbi nhi\u1ec1u b\u1ea1ch c\u1ea7u trung t\u00ednh Cit-H3+ v\u00e0 MPO+ trong ph\u1ed5i. Ngo\u00e0i ra, m\u1ea1ng DNA ngo\u1ea1i b\u00e0o v\u1edbi MPO v\u00e0 Cit-H3 c\u0169ng \u0111\u00e3 \u0111\u01b0\u1ee3c b\u00e1o c\u00e1o \u1edf b\u1ec7nh nh\u00e2n COVID-19. Ng\u01b0\u1eddi ta cho r\u1eb1ng trong c\u00e1c m\u1ea1ch m\u00e1u ph\u1ed5i, s\u1ef1 tr\u00f9ng v\u1ecb c\u1ee7a b\u1ea1ch c\u1ea7u trung t\u00ednh v\u1edbi ti\u1ec3u c\u1ea7u cho th\u1ea5y vai tr\u00f2 c\u00f3 th\u1ec3 c\u00f3 c\u1ee7a ch\u00fang trong vi\u1ec7c h\u00ecnh th\u00e0nh vi m\u1ea1ch huy\u1ebft kh\u1ed1i . Tuy nhi\u00ean, c\u1ea7n ph\u1ea3i nghi\u00ean c\u1ee9u th\u00eam \u0111\u1ec3 hi\u1ec3u vai tr\u00f2 th\u1ef1c s\u1ef1 c\u1ee7a NET g\u00e2y ra s\u1ef1 k\u1ebft t\u1eadp ti\u1ec3u c\u1ea7u trong huy\u1ebft kh\u1ed1i mi\u1ec5n d\u1ecbch.<\/li>\n<\/ul>\n

          M\u1eb7c d\u00f9 d\u1eef li\u1ec7u v\u1ec1 ph\u1ea3n \u1ee9ng mi\u1ec5n d\u1ecbch \u0111\u1ed1i v\u1edbi COVID-19 \u1edf tr\u1ebb em c\u00f2n h\u1ea1n ch\u1ebf, nh\u01b0ng m\u1ed9t s\u1ed1 nghi\u00ean c\u1ee9u \u0111\u00e3 b\u00e1o c\u00e1o r\u1eb1ng b\u1ec7nh n\u1eb7ng \u1edf tr\u1ebb em c\u00f3 li\u00ean quan \u0111\u1ebfn b\u00e9o ph\u00ec. H\u01a1n n\u1eefa, n\u1ed3ng \u0111\u1ed9 protein ph\u1ea3n \u1ee9ng C (CRP) v\u00e0 IL-6 cao \u0111\u00e3 \u0111\u01b0\u1ee3c nh\u1eadn th\u1ea5y \u1edf tr\u1ebb em, cho th\u1ea5y t\u00ecnh tr\u1ea1ng ti\u1ec1n vi\u00eam nhi\u1ec5m \u1edf tr\u1ebb em c\u00f3 th\u1ec3 t\u01b0\u01a1ng t\u1ef1 nh\u01b0 \u1edf ng\u01b0\u1eddi l\u1edbn b\u1ecb nhi\u1ec5m COVID-19. Tuy nhi\u00ean, ch\u00fang ta kh\u00f4ng th\u1ec3 lo\u1ea1i tr\u1eeb kh\u1ea3 n\u0103ng x\u1ea3y ra c\u00e1c ph\u1ea3n \u1ee9ng mi\u1ec5n d\u1ecbch kh\u00e1c nhau.<\/p>\n

          Diorio et al. c\u00f4ng nh\u1eadn r\u1eb1ng k\u00edch ho\u1ea1t mi\u1ec5n d\u1ecbch qua trung gian SARS-CoV-2 c\u00f3 li\u00ean quan \u0111\u1ebfn r\u1ed1i lo\u1ea1n ch\u1ee9c n\u0103ng n\u1ed9i m\u00f4. \u1ede tr\u1ebb em, m\u1ee9c \u0111\u1ed9 interleukin v\u00e0 t\u1ebf b\u00e0o B \u0111\u00e3 \u0111\u01b0\u1ee3c quan s\u00e1t th\u1ea5y trong giai \u0111o\u1ea1n vi\u00eam \u0111a h\u1ec7 th\u1ed1ng c\u1ea5p t\u00ednh. Protein S c\u1ee7a kh\u00e1ng th\u1ec3 d\u1ef1a tr\u00ean SARS-CoV-1 c\u00f3 th\u1ec3 ph\u1ea3n \u1ee9ng ch\u00e9o, tuy nhi\u00ean, COVID-19 ch\u01b0a \u0111\u01b0\u1ee3c b\u00e1o c\u00e1o l\u00e0 tr\u1edf n\u00ean t\u1ed3i t\u1ec7 h\u01a1n \u1edf nh\u1eefng ng\u01b0\u1eddi nh\u1eadn huy\u1ebft t\u01b0\u01a1ng \u0111ang h\u1ed3i ph\u1ee5c.<\/p>\n

          C\u00e1c nh\u00e0 nghi\u00ean c\u1ee9u \u0111\u00e3 b\u00e1o c\u00e1o r\u1eb1ng s\u1ef1 k\u00edch th\u00edch qu\u00e1 m\u1ee9c c\u1ee7a h\u1ec7 th\u1ed1ng mi\u1ec5n d\u1ecbch c\u00f3 li\u00ean quan \u0111\u1ebfn vi\u1ec7c t\u0103ng m\u1ee9c \u0111\u1ed9 c\u00e1c d\u1ea5u hi\u1ec7u vi\u00eam nhi\u1ec5m. Nh\u1eefng d\u1ea5u hi\u1ec7u n\u00e0y bao g\u1ed3m ferritin, IL-6, t\u1ed1c \u0111\u1ed9 l\u1eafng h\u1ed3ng c\u1ea7u, pro-calcitonin, fibrinogen, D-dimer, v\u00e0 quan tr\u1ecdng nh\u1ea5t l\u00e0 protein ph\u1ea3n \u1ee9ng C (CRP). M\u1eb7t kh\u00e1c, m\u1ee9c \u0111\u1ed9 cao c\u1ee7a c\u00e1c d\u1ea5u hi\u1ec7u vi\u00eam b\u1ea9m sinh c\u1ea5p t\u00ednh c\u0169ng \u0111\u01b0\u1ee3c ph\u00e1t hi\u1ec7n c\u00f3 li\u00ean quan \u0111\u1ebfn c\u00e1c bi\u1ebfn ch\u1ee9ng th\u1ea7n kinh, b\u1edfi v\u00ec c\u00e1c cytokine ti\u1ec1n vi\u00eam ph\u00e1 v\u1ee1 h\u00e0ng r\u00e0o m\u00e1u n\u00e3o, k\u00edch th\u00edch vi\u00eam th\u1ea7n kinh v\u00e0 k\u00edch ho\u1ea1t c\u00e1c t\u1ebf b\u00e0o th\u1ea7n kinh \u0111\u1ec7m. Nh\u1eefng hi\u1ec7n t\u01b0\u1ee3ng n\u00e0y g\u00e2y k\u00edch th\u00edch th\u1ea7n kinh qu\u00e1 m\u1ee9c, m\u1ec7t m\u1ecfi, m\u1ea5t kh\u1edbp th\u1ea7n kinh, b\u1ec7nh n\u00e3o v\u00e0 ch\u1ebft t\u1ebf b\u00e0o th\u1ea7n kinh.<\/p>\n

          Ngu\u1ed3n tham kh\u1ea3o<\/strong>: Suliman Khan, Rabeea Siddique, \u00a0Xiao Hao, Yueting Lin, Yuxin Liu, Xiaoyan Wang, Linlin Hua, and Ghulam Nabi, \u201cThe COVID-19 infection in children and its association with the immune system, prenatal stress, and neurological complications\u201d, International Journal of Biological Sciences<\/em>, 2022.<\/p>\n","protected":false},"excerpt":{"rendered":"

          H\u1ec7 mi\u1ec5n d\u1ecbch l\u00e0 m\u1ed9t ph\u1ea7n r\u1ea5t quan tr\u1ecdng trong vi\u1ec7c b\u1ea3o v\u1ec7 c\u01a1 th\u1ec3 kh\u1ecfi c\u00e1c t\u00e1c nh\u00e2n g\u00e2y b\u1ec7nh nh\u01b0 virus v\u00e0 vi khu\u1ea9n. V\u1edbi s\u1ef1 b\u00f9ng ph\u00e1t c\u1ee7a \u0111\u1ea1i d\u1ecbch COVID-19, vai tr\u00f2 c\u1ee7a h\u1ec7 mi\u1ec5n d\u1ecbch \u1edf tr\u1ebb em b\u1ecb COVID-19 \u0111\u00e3 \u0111\u01b0\u1ee3c nghi\u00ean c\u1ee9u r\u1ed9ng r\u00e3i. 1. T\u1ed5ng quan Ch\u00fang […]<\/p>\n","protected":false},"author":4,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[20,33],"tags":[],"yoast_head":"\nVai tr\u00f2 c\u1ee7a h\u1ec7 mi\u1ec5n d\u1ecbch \u1edf tr\u1ebb em b\u1ecb COVID 19<\/title>\n<meta name=\"description\" content=\"H\u1ec7 mi\u1ec5n d\u1ecbch l\u00e0 m\u1ed9t ph\u1ea7n r\u1ea5t quan tr\u1ecdng trong vi\u1ec7c b\u1ea3o v\u1ec7 c\u01a1 th\u1ec3 kh\u1ecfi c\u00e1c t\u00e1c nh\u00e2n g\u00e2y b\u1ec7nh nh\u01b0 virus v\u00e0 vi khu\u1ea9n\" \/>\n<meta name=\"robots\" content=\"noindex, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Vai tr\u00f2 c\u1ee7a h\u1ec7 mi\u1ec5n d\u1ecbch \u1edf tr\u1ebb em b\u1ecb COVID 19\" \/>\n<meta property=\"og:description\" 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