{"id":26766,"date":"2023-04-22T22:26:49","date_gmt":"2023-04-22T15:26:49","guid":{"rendered":"http:\/\/noithathoaphat.in\/ctv\/?p=26766"},"modified":"2023-04-22T22:26:49","modified_gmt":"2023-04-22T15:26:49","slug":"hieu-qua-cua-thuoc-moi-sparsentan-trong-dieu-tri-benh-than-iga","status":"publish","type":"post","link":"http:\/\/noithathoaphat.in\/ctv\/index.php\/2023\/04\/22\/hieu-qua-cua-thuoc-moi-sparsentan-trong-dieu-tri-benh-than-iga\/","title":{"rendered":"Hi\u1ec7u qu\u1ea3 c\u1ee7a thu\u1ed1c m\u1edbi Sparsentan trong \u0111i\u1ec1u tr\u1ecb b\u1ec7nh th\u1eadn IgA"},"content":{"rendered":"

B\u1ec7nh th\u1eadn IgA hay c\u00f2n \u0111\u01b0\u1ee3c g\u1ecdi l\u00e0 b\u1ec7nh Berger, l\u00e0 m\u1ed9t b\u1ec7nh th\u1eadn c\u00f3 t\u00ednh ch\u1ea5t vi\u00eam nhi\u1ec5m m\u1ea1n t\u00ednh. Hi\u1ec7n nay, Sparsentan – m\u1ed9t lo\u1ea1i thu\u1ed1c m\u1edbi \u0111ang \u0111\u01b0\u1ee3c nghi\u00ean c\u1ee9u v\u00e0 ph\u00e1t tri\u1ec3n \u0111\u1ec3 \u0111i\u1ec1u tr\u1ecb b\u1ec7nh th\u1eadn IgA. Sparsentan \u0111\u01b0\u1ee3c ch\u1ee9ng minh t\u00e1c d\u1ee5ng \u1ee9c ch\u1ebf c\u1ea3 hai \u0111\u01b0\u1eddng th\u1ee5 th\u1ec3 angiotensin v\u00e0 endothelin, gi\u00fap gi\u1ea3m t\u0103ng huy\u1ebft \u00e1p v\u00e0 b\u1ea3o v\u1ec7 t\u1ebf b\u00e0o th\u1eadn kh\u1ecfi s\u1ef1 t\u1ed5n th\u01b0\u01a1ng. C\u00e1c nghi\u00ean c\u1ee9u s\u01a1 b\u1ed9 \u0111\u00e3 cho th\u1ea5y hi\u1ec7u qu\u1ea3 c\u1ee7a Sparsentan trong vi\u1ec7c gi\u1ea3m protein trong n\u01b0\u1edbc ti\u1ec3u v\u00e0 c\u1ea3i thi\u1ec7n ch\u1ee9c n\u0103ng th\u1eadn \u1edf b\u1ec7nh nh\u00e2n b\u1ecb b\u1ec7nh Berger v\u00e0 \u0111\u00e3 \u0111\u01b0\u1ee3c ch\u1ea5p thu\u1eadn s\u1eed d\u1ee5ng\u00a0<\/strong><\/p>\n

1.Gi\u1edbi thi\u1ec7u v\u1ec1 b\u1ec7nh Berger (b\u1ec7nh th\u1eadn IgA)<\/strong><\/h2>\n

1.1 T\u00ecm hi\u1ec3u v\u1ec1 b\u1ec7nh Berger\u00a0<\/span><\/h3>\n

B\u1ec7nh th\u1eadn do globulin mi\u1ec5n d\u1ecbch A – IgA (Berger)<\/a> l\u00e0 m\u1ed9t lo\u1ea1i b\u1ec7nh th\u1eadn c\u00f3 t\u00ednh ch\u1ea5t vi\u00eam nhi\u1ec5m m\u1ea1n t\u00ednh. B\u1ec7nh \u0111\u01b0\u1ee3c g\u00e2y ra b\u1edfi s\u1ef1 t\u00edch t\u1ee5 c\u00e1c kh\u00e1ng th\u1ec3 IgA trong m\u00f4 th\u1eadn nhi\u1ec1u h\u01a1n c\u00e1c lo\u1ea1i globulin mi\u1ec5n d\u1ecbch kh\u00e1c, d\u1eabn \u0111\u1ebfn vi\u00eam v\u00e0 t\u1ed5n th\u01b0\u01a1ng c\u00e1c m\u00f4 v\u00e0 m\u1ea1ch m\u00e1u th\u1eadn. B\u1ec7nh vi\u00eam c\u1ea7u th\u1eadn nguy\u00ean ph\u00e1t n\u00e0y ph\u1ed5 bi\u1ebfn nh\u1ea5t tr\u00ean to\u00e0n th\u1ebf gi\u1edbi v\u1edbi t\u1ef7 l\u1ec7 m\u1eafc l\u00e0 2,5 tr\u00ean 100.000 d\u00e2n m\u1ed7i n\u0103m. Trong \u0111\u00f3, t\u1ef7 l\u1ec7 m\u1eafc b\u1ec7nh r\u1ea5t kh\u00e1c nhau gi\u1eefa c\u00e1c qu\u1ed1c gia v\u00e0 c\u00f3 th\u1ec3 chi\u1ebfm t\u1eeb 2% \u0111\u1ebfn 40% trong t\u1ea5t c\u1ea3 c\u00e1c b\u1ec7nh c\u1ea7u th\u1eadn nguy\u00ean ph\u00e1t. IgAN nguy\u00ean ph\u00e1t th\u01b0\u1eddng g\u1eb7p \u1edf nam h\u01a1n \u1edf n\u1eef.<\/span><\/p>\n

\"B\u1ec7nh
B\u1ec7nh th\u1eadn IgA<\/figcaption><\/figure>\n

1.2 Sinh l\u00fd b\u1ec7nh c\u1ee7a b\u1ec7nh th\u1eadn IgA (b\u1ec7nh Berger)<\/span><\/h3>\n

B\u1ec7nh th\u1eadn IgA d\u01b0\u1eddng nh\u01b0 l\u00e0 k\u1ebft qu\u1ea3 c\u1ee7a m\u1ed9t chu\u1ed7i c\u00e1c s\u1ef1 ki\u1ec7n \u0111\u01b0\u1ee3c s\u1eafp x\u1ebfp theo th\u1ee9 t\u1ef1. B\u1eaft \u0111\u1ea7u t\u1eeb globulin mi\u1ec5n d\u1ecbch IgA1 thi\u1ebfu galactose (ch\u1ee9a \u00edt h\u01a1n l\u01b0\u1ee3ng b\u1ed5 sung \u0111\u1ea7y \u0111\u1ee7 c\u00e1c g\u1ed1c galactose tr\u00ean c\u00e1c O-glycan trong c\u1ea5u tr\u00fac). Nh\u1eefng ch\u1ea5t n\u00e0y c\u00f3 th\u1ec3 ho\u1ea1t \u0111\u1ed9ng nh\u01b0 c\u00e1c kh\u00e1ng nguy\u00ean t\u1ef1 \u0111\u1ed9ng k\u00edch ho\u1ea1t qu\u00e1 tr\u00ecnh s\u1ea3n xu\u1ea5t c\u00e1c t\u1ef1 kh\u00e1ng th\u1ec3 \u0111\u1eb7c hi\u1ec7u v\u1edbi glycan v\u00e0 h\u00ecnh th\u00e0nh c\u00e1c ph\u1ee9c h\u1ee3p mi\u1ec5n d\u1ecbch tu\u1ea7n ho\u00e0n \u0111\u01b0\u1ee3c l\u1eafng \u0111\u1ecdng trong trung m\u00f4 th\u1eadn. Sau \u0111\u00f3 g\u00e2y ra c\u00e1c t\u1ed5n th\u01b0\u01a1ng c\u1ea7u th\u1eadn th\u00f4ng qua vi\u1ec7c gi\u1ea3i ph\u00f3ng cytokine ti\u1ec1n vi\u00eam. IgA l\u1eafng \u0111\u1ecdng ch\u1ee7 y\u1ebfu l\u00e0 IgA1 cao ph\u00e2n t\u1eed, ch\u1ee7 y\u1ebfu c\u00f3 ngu\u1ed3n g\u1ed1c t\u1eeb h\u1ec7 th\u1ed1ng mi\u1ec5n d\u1ecbch ni\u00eam m\u1ea1c v\u00e0 t\u00edch t\u1ee5 b\u00ean trong c\u00e1c m\u1ea1ch m\u00e1u nh\u1ecf c\u1ee7a th\u1eadn<\/span><\/p>\n

1.3 Tri\u1ec7u ch\u1ee9ng\u00a0<\/span><\/h3>\n

B\u1ec7nh th\u1eadn IgA l\u00e0 m\u1ed9t b\u1ec7nh th\u1ea7m l\u1eb7ng c\u00f3 th\u1ec3 kh\u00f4ng ph\u00e1t hi\u1ec7n \u0111\u01b0\u1ee3c trong nhi\u1ec1u n\u0103m v\u00e0 c\u00f3 th\u1ec3 x\u1ea3y ra \u1edf m\u1ecdi l\u1ee9a tu\u1ed5i nh\u01b0ng c\u00e1c tri\u1ec7u ch\u1ee9ng th\u01b0\u1eddng b\u1eaft \u0111\u1ea7u tr\u01b0\u1edbc 40 tu\u1ed5i. Tri\u1ec7u ch\u1ee9ng ph\u1ed5 bi\u1ebfn nh\u1ea5t l\u00e0 ti\u1ec3u ra m\u00e1u (ti\u1ec3u m\u00e1u). Sau nhi\u1ec1u n\u0103m ti\u1ebfn tri\u1ec3n b\u1ec7nh, tri\u1ec7u ch\u1ee9ng g\u1ed3m s\u01b0ng t\u1ea5y, nhi\u1ec5m tr\u00f9ng \u0111\u01b0\u1eddng h\u00f4 h\u1ea5p tr\u00ean t\u00e1i ph\u00e1t ho\u1eb7c b\u1ec7nh \u0111\u01b0\u1eddng ru\u1ed9t. Nh\u1eefng ng\u01b0\u1eddi m\u1eafc b\u1ec7nh th\u1eadn IgA c\u0169ng c\u00f3 th\u1ec3 b\u1ecb \u0111au s\u01b0\u1eddn v\u00e0 s\u1ed1t nh\u1eb9. Tri\u1ec7u ch\u1ee9ng hi\u1ebfm g\u1eb7p \u1edf c\u00e1c b\u1ec7nh nh\u00e2n l\u00e0 huy\u1ebft \u00e1p c\u00f3 th\u1ec3 tr\u1edf n\u00ean cao \u0111\u1ebfn m\u1ee9c nguy hi\u1ec3m<\/span><\/p>\n

1.4 Ch\u1ea9n \u0111o\u00e1n\u00a0<\/span><\/h3>\n

C\u00f3 th\u1ec3 l\u00e0m c\u00e1c x\u00e9t nghi\u1ec7m ki\u1ec3m tra th\u01b0\u1eddng xuy\u00ean: ki\u1ec3m tra huy\u1ebft \u00e1p, x\u00e9t nghi\u1ec7m Cholesterol, ki\u1ec3m tra protein trong n\u01b0\u1edbc ti\u1ec3u, ki\u1ec3m tra protein trong m\u00e1u, sinh thi\u1ebft th\u1eadn (\u0111\u1ec3 x\u00e1c \u0111\u1ecbnh ti\u1ec1n ch\u1ea5t c\u1ee7a IgA)<\/span><\/p>\n

1.5 \u0110i\u1ec1u tr\u1ecb\u00a0<\/span><\/h3>\n

C\u00e1c lo\u1ea1i thu\u1ed1c d\u00f9ng \u0111i\u1ec1u tr\u1ecb b\u1ec7nh g\u1ed3m:\u00a0<\/span><\/p>\n

    \n
  • Nh\u00f3m thu\u1ed1c ch\u1ed1ng cao huy\u1ebft \u00e1p: Nh\u1eefng lo\u1ea1i thu\u1ed1c n\u00e0y gi\u00fap h\u1ea1 huy\u1ebft \u00e1p v\u00e0 b\u1ea3o v\u1ec7 th\u1eadn, c\u0169ng ng\u0103n ng\u1eeba m\u1ea5t protein trong n\u01b0\u1edbc ti\u1ec3u\u00a0<\/span><\/li>\n
  • Corticosteroid: C\u00e1c thu\u1ed1c l\u00e0m gi\u1ea3m vi\u00eam v\u00e0 m\u00f4 s\u1eb9o b\u00ean trong th\u1eadn\u00a0<\/span><\/li>\n
  • D\u1ea7u c\u00e1 theo toa: gi\u00fap gi\u1ea3m vi\u00eam v\u00e0 t\u1ed5n th\u01b0\u01a1ng trong th\u1eadn\u00a0<\/span><\/li>\n
  • Nh\u00f3m thu\u1ed1c h\u1ea1 Cholesterol: Nh\u1eefng ng\u01b0\u1eddi b\u1ecb t\u1ed5n th\u01b0\u01a1ng th\u1eadn c\u00f3 nguy c\u01a1 b\u1ecb \u0111\u1ed9t qu\u1ef5 v\u00e0 \u0111au tim cao h\u01a1n. Ki\u1ec3m so\u00e1t cholesterol c\u00f3 th\u1ec3 gi\u00fap gi\u1ea3m nguy c\u01a1 m\u1eafc b\u1ec7nh l\u00fd tim m\u1ea1ch<\/span><\/li>\n<\/ul>\n

    Ph\u01b0\u01a1ng ph\u00e1p \u0111i\u1ec1u tr\u1ecb kh\u00e1c:<\/span><\/p>\n

      \n
    • Thay \u0111\u1ed5i ch\u1ebf \u0111\u1ed9 \u0103n u\u1ed1ng: gi\u00fap gi\u1ea3m ch\u1ea5t b\u00e9o v\u00e0 cholesterol. Nh\u1eefng th\u1ee9 n\u00e0y c\u00f3 th\u1ec3 g\u00e2y t\u00edch t\u1ee5 m\u1ea3ng b\u00e1m trong \u0111\u1ed9ng m\u1ea1ch th\u1eadn v\u00e0 g\u00e2y t\u1ed5n th\u01b0\u01a1ng th\u00eam cho th\u1eadn<\/span><\/li>\n
    • B\u1ecf thu\u1ed1c l\u00e1<\/span><\/li>\n
    • T\u1eadp th\u1ec3 d\u1ee5c v\u00e0 duy tr\u00ec tr\u1ecdng l\u01b0\u1ee3ng c\u01a1 th\u1ec3 b\u00ecnh th\u01b0\u1eddng<\/span><\/li>\n<\/ul>\n

      1.6 Bi\u1ebfn ch\u1ee9ng c\u1ee7a b\u1ec7nh th\u1eadn IgA<\/span><\/h3>\n

      C\u00e1c bi\u1ebfn ch\u1ee9ng kh\u00e1c: huy\u1ebft \u00e1p cao v\u00e0 l\u01b0\u1ee3ng Cholesterol cao trong m\u00e1u<\/span><\/p>\n

      2.Th\u00f4ng tin v\u1ec1 thu\u1ed1c m\u1edbi Sparsentan<\/strong><\/h2>\n

      FDA \u0111\u00e3 ph\u00ea duy\u1ec7t c\u1ea5p t\u1ed1c cho vi\u1ec7c s\u1eed d\u1ee5ng Sparsentan \u0111\u01b0\u1eddng u\u1ed1ng (bi\u1ec7t d\u01b0\u1ee3c Filspari l\u00e0m li\u1ec7u ph\u00e1p kh\u00f4ng \u1ee9c ch\u1ebf mi\u1ec5n d\u1ecbch \u0111\u1ea7u ti\u00ean v\u00e0 duy nh\u1ea5t \u0111\u1ec3 \u0111i\u1ec1u tr\u1ecb b\u1ec7nh th\u1eadn IgA (IgAN)). Th\u00f4ng qua nghi\u00ean c\u1ee9u th\u1eed nghi\u1ec7m l\u00e2m s\u00e0ng to\u00e0n c\u1ea7u Protect th\u1ef1c hi\u1ec7n so s\u00e1nh li\u1ec1u 400mg c\u1ee7a Sparsentan so v\u1edbi li\u1ec1u 300mg c\u1ee7a Irbesartan \u0111\u1ed1i v\u1edbi b\u1ec7nh nh\u00e2n m\u1eafc IgAN v\u00e0 protein ni\u1ec7u. K\u1ebft qu\u1ea3 nghi\u00ean c\u1ee9u sau 36 tu\u1ea7n \u0111i\u1ec1u tr\u1ecb \u0111\u01b0\u1ee3c b\u00e1o c\u00e1o r\u1eb1ng l\u01b0\u1ee3ng protein ni\u1ec7u \u0111\u00e3 gi\u1ea3m 49,8% so v\u1edbi ban \u0111\u1ea7u so v\u1edbi m\u1ee9c gi\u1ea3m protein ni\u1ec7u trung b\u00ecnh khi \u0111i\u1ec1u tr\u1ecb d\u1ef1a tr\u00ean Irbesartan ch\u1ec9 l\u00e0 15,1%. Nh\u1eefng k\u1ebft qu\u1ea3 ti\u1ec1n l\u00e2m s\u00e0ng cho th\u1ea5y li\u1ec7u ph\u00e1p n\u00e0y \u0111\u00e1p \u1ee9ng ti\u00eau ch\u00ed hi\u1ec7u qu\u1ea3 ch\u00ednh \u0111\u01b0\u1ee3c ch\u1ec9 \u0111\u1ecbnh tr\u01b0\u1edbc, ch\u1ee9ng minh nh\u1eefng c\u1ea3i thi\u1ec7n \u0111\u00e1ng k\u1ec3 v\u1ec1 m\u1eb7t l\u00e2m s\u00e0ng v\u00e0 c\u00f3 \u00fd ngh\u0129a th\u1ed1ng k\u00ea \u0111\u1ed1i v\u1edbi protein ni\u1ec7u<\/span><\/p>\n

      \"Sparsentan
      Sparsentan (Filspari)<\/figcaption><\/figure>\n

      2.1 Nh\u00f3m d\u01b0\u1ee3c l\u00fd v\u00e0 ch\u1ec9 \u0111\u1ecbnh s\u1eed d\u1ee5ng<\/span><\/h3>\n

      Sparsentan l\u00e0 m\u1ed9t ch\u1ea5t \u0111\u1ed1i kh\u00e1ng th\u1ee5 th\u1ec3 endothelin v\u00e0 angiotensin II \u0111\u01b0\u1ee3c ch\u1ec9 \u0111\u1ecbnh \u0111\u1ec3 gi\u1ea3m protein ni\u1ec7u \u1edf ng\u01b0\u1eddi l\u1edbn m\u1eafc b\u1ec7nh th\u1eadn nguy\u00ean ph\u00e1t immunoglobulin A c\u00f3 nguy c\u01a1 ti\u1ebfn tri\u1ec3n b\u1ec7nh nhanh, th\u01b0\u1eddng c\u00f3 t\u1ef7 l\u1ec7 protein-to-creatinine trong n\u01b0\u1edbc ti\u1ec3u (UPCR) \u22651,5 g<\/span><\/p>\n

      2.2 C\u01a1 ch\u1ebf ho\u1ea1t \u0111\u1ed9ng\u00a0<\/span><\/h3>\n

      Sparsentan l\u00e0 m\u1ed9t ph\u00e2n t\u1eed ho\u1ea1t \u0111\u1ed9ng nh\u01b0 m\u1ed9t ch\u1ea5t \u0111\u1ed1i kh\u00e1ng k\u00e9p c\u1ee7a th\u1ee5 th\u1ec3 Endothelin lo\u1ea1i A v\u00e0 th\u1ee5 th\u1ec3 Angiotensin II lo\u1ea1i 1.N\u00f3 s\u1edf h\u1eefu hai c\u01a1 ch\u1ebf ho\u1ea1t \u0111\u1ed9ng \u0111\u00e3 \u0111\u01b0\u1ee3c ki\u1ec3m ch\u1ee9ng l\u00e2m s\u00e0ng v\u00e0 ng\u0103n ch\u1eb7n c\u00f3 ch\u1ecdn l\u1ecdc ho\u1ea1t \u0111\u1ed9ng c\u1ee7a hai t\u00e1c nh\u00e2n g\u00e2y co m\u1ea1ch v\u00e0 gi\u1ea3m thi\u1ec3u m\u1ea1nh Angiotensin II (Ang II) v\u00e0 Endothelin 1 (ET-1) t\u1ea1i c\u00e1c th\u1ee5 th\u1ec3 t\u01b0\u01a1ng \u1ee9ng c\u1ee7a ch\u00fang. ET-1 v\u00e0 Ang II g\u00f3p ph\u1ea7n v\u00e0o c\u01a1 ch\u1ebf b\u1ec7nh sinh c\u1ee7a b\u1ec7nh th\u1eadn immunoglobulin A (IgAN). Khi qu\u00e1 tr\u00ecnh s\u1ea3n xu\u1ea5t ET-1 v\u00e0 Ang II t\u0103ng l\u00ean s\u1ebd k\u00edch th\u00edch c\u00e1c kh\u00e1ng th\u1ec3 IgA1 thi\u1ebfu galactose (Gd-IgA1) k\u00edch ho\u1ea1t v\u00e0 t\u0103ng sinh t\u1ebf b\u00e0o trung m\u00f4. B\u1eb1ng c\u00e1ch \u0111\u00f3ng vai tr\u00f2 v\u1eeba l\u00e0 ch\u1ea5t \u1ee9c ch\u1ebf th\u1ee5 th\u1ec3 angiotensin (ARB) v\u1eeba l\u00e0 ch\u1ea5t \u0111\u1ed1i kh\u00e1ng th\u1ee5 th\u1ec3 endothelin (ERA), Sparsentan l\u00e0m gi\u1ea3m protein ni\u1ec7u \u1edf b\u1ec7nh nh\u00e2n IgAN<\/span><\/p>\n

      2.3 D\u01b0\u1ee3c \u0111\u1ed9ng h\u1ecdc\u00a0<\/span><\/h3>\n

      H\u1ea5p thu: Sau khi d\u00f9ng li\u1ec1u \u0111\u01a1n 200-1600mg, Cmax v\u00e0 AUC t\u0103ng \u00edt h\u01a1n t\u1ec9 l\u1ec7 li\u1ec1u. N\u1ed3ng \u0111\u1ed9 trong huy\u1ebft t\u01b0\u01a1ng \u1edf tr\u1ea1ng th\u00e1i \u1ed5n \u0111\u1ecbnh trong v\u00f2ng 7 ng\u00e0y. Sau khi d\u00f9ng li\u1ec1u 400 mg Sparsentan h\u00e0ng ng\u00e0y, Cmax \u1edf tr\u1ea1ng th\u00e1i \u1ed5n \u0111\u1ecbnh l\u00e0 6,47 \u03bcg\/mL v\u00e0 AUC l\u00e0 63,6 \u03bcg\u00d7h\/mL. D\u00f9ng m\u1ed9t li\u1ec1u u\u1ed1ng duy nh\u1ea5t 800mg sau b\u1eefa \u0103n nhi\u1ec1u ch\u1ea5t b\u00e9o nhi\u1ec1u n\u0103ng l\u01b0\u1ee3ng l\u00e0m t\u0103ng AUC v\u00e0 Cmax l\u1ea7n l\u01b0\u1ee3t l\u00e0 22% v\u00e0 108%<\/span><\/p>\n

      Ph\u00e2n b\u1ed1: Th\u1ec3 t\u00edch ph\u00e2n b\u1ed1(Vd) \u1edf li\u1ec1u khuy\u1ebfn c\u00e1o tr\u1ea1ng th\u00e1i \u1ed5n \u0111\u1ecbnh l\u00e0 61,4L. Sparsentan li\u00ean k\u1ebft h\u01a1n 99% v\u1edbi protein huy\u1ebft t\u01b0\u01a1ng<\/span><\/p>\n

      Chuy\u1ec3n h\u00f3a: Sparsentan ch\u1ee7 y\u1ebfu \u0111\u01b0\u1ee3c chuy\u1ec3n h\u00f3a b\u1edfi cytochrom P450 3A<\/span><\/p>\n

      Th\u1ea3i tr\u1eeb: Sparsentan ch\u1ee7 y\u1ebfu \u0111\u01b0\u1ee3c b\u00e0i ti\u1ebft qua ph\u00e2n v\u00e0 n\u01b0\u1edbc ti\u1ec3u v\u1edbi chu k\u1ef3 b\u00e1n r\u00e3 \u01b0\u1edbc t\u00ednh l\u00e0 9,6 gi\u1edd \u1edf tr\u1ea1ng th\u00e1i \u1ed5n \u0111\u1ecbnh\u00a0<\/span><\/p>\n

      2.4 T\u00e1c d\u1ee5ng ph\u1ee5\u00a0<\/span><\/h3>\n

      Sparsentan ngo\u00e0i hi\u1ec7u qu\u1ea3 \u0111\u00e1ng k\u1ec3 tr\u00ean b\u1ec7nh th\u1eadn IgA c\u00f2n g\u00e2y ra c\u00e1c t\u00e1c d\u1ee5ng ph\u1ee5 ph\u1ed5 bi\u1ebfn: m\u1edd m\u1eaft, \u1edbn l\u1ea1nh, l\u00fa l\u1eabn, ch\u00f3ng m\u1eb7t, ng\u1ea5t x\u1ec9u, lo l\u1eafng, da nh\u1ee3t nh\u1ea1t, t\u00ea ng\u1ee9a ran \u1edf b\u00e0n tay b\u00e0n ch\u00e2n, m\u1ec7t m\u1ecfi, t\u0103ng ho\u1eb7c gi\u1ea3m c\u00e2n b\u1ea5t th\u01b0\u1eddng. M\u1ed9t s\u1ed1 t\u00e1c d\u1ee5ng ph\u1ee5 \u00edt ph\u1ed5 bi\u1ebfn h\u01a1n: k\u00edch \u0111\u1ed9ng, h\u00f4n m\u00ea, s\u01b0ng m\u1eb7t, c\u00e1u g\u1eaft<\/span><\/p>\n

      2.5 Li\u1ec1u d\u00f9ng<\/span><\/h3>\n

      Ng\u01b0\u1eddi l\u1edbn: li\u1ec1u ban \u0111\u1ea7u 200mg m\u1ed7i ng\u00e0y 1 l\u1ea7n v\u00e0o bu\u1ed5i s\u00e1ng ho\u1eb7c t\u1ed1i\u00a0<\/span><\/p>\n

      Tr\u1ebb em: h\u1ecfi \u00fd ki\u1ebfn b\u00e1c s\u0129<\/span><\/p>\n

      3.K\u1ebft lu\u1eadn\u00a0<\/strong><\/h2>\n

      Vi\u1ec7c ph\u00ea duy\u1ec7t nhanh ch\u00f3ng Sparsentan l\u00e0 m\u1ed9t c\u1ed9t m\u1ed1c quan tr\u1ecdng nh\u1eb1m th\u00fac \u0111\u1ea9y m\u1ed9t ph\u01b0\u01a1ng ph\u00e1p \u0111i\u1ec1u tr\u1ecb bi\u1ebfn \u0111\u1ed5i cho c\u1ed9ng \u0111\u1ed3ng ng\u01b0\u1eddi m\u1eafc ph\u1ea3i b\u1ec7nh th\u1eadn IgA<\/span><\/p>\n","protected":false},"excerpt":{"rendered":"

      B\u1ec7nh th\u1eadn IgA hay c\u00f2n \u0111\u01b0\u1ee3c g\u1ecdi l\u00e0 b\u1ec7nh Berger, l\u00e0 m\u1ed9t b\u1ec7nh th\u1eadn c\u00f3 t\u00ednh ch\u1ea5t vi\u00eam nhi\u1ec5m m\u1ea1n t\u00ednh. Hi\u1ec7n nay, Sparsentan – m\u1ed9t lo\u1ea1i thu\u1ed1c m\u1edbi \u0111ang \u0111\u01b0\u1ee3c nghi\u00ean c\u1ee9u v\u00e0 ph\u00e1t tri\u1ec3n \u0111\u1ec3 \u0111i\u1ec1u tr\u1ecb b\u1ec7nh th\u1eadn IgA. Sparsentan \u0111\u01b0\u1ee3c ch\u1ee9ng minh t\u00e1c d\u1ee5ng \u1ee9c ch\u1ebf c\u1ea3 hai \u0111\u01b0\u1eddng th\u1ee5 th\u1ec3 […]<\/p>\n","protected":false},"author":54,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[12],"tags":[],"yoast_head":"\nHi\u1ec7u qu\u1ea3 c\u1ee7a thu\u1ed1c m\u1edbi Sparsentan trong \u0111i\u1ec1u tr\u1ecb b\u1ec7nh th\u1eadn IgA<\/title>\n<meta name=\"description\" content=\"N\u1eeda \u0111\u1ea7u n\u0103m 2023 \u0111\u00e1nh d\u1ea5u b\u01b0\u1edbc ngo\u1eb7c m\u1edbi khi Sparsentan \u0111\u01b0\u1ee3c c\u00f4ng nh\u1eadn l\u00e0 li\u1ec7u ph\u00e1p t\u1ed1i \u01b0u v\u00e0 hi\u1ec7u qu\u1ea3 trong \u0111i\u1ec1u tr\u1ecb b\u1ec7nh th\u1eadn IgA\" \/>\n<meta name=\"robots\" content=\"noindex, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Hi\u1ec7u qu\u1ea3 c\u1ee7a thu\u1ed1c m\u1edbi Sparsentan trong \u0111i\u1ec1u tr\u1ecb b\u1ec7nh th\u1eadn IgA\" \/>\n<meta property=\"og:description\" content=\"N\u1eeda \u0111\u1ea7u n\u0103m 2023 \u0111\u00e1nh d\u1ea5u b\u01b0\u1edbc ngo\u1eb7c m\u1edbi khi Sparsentan \u0111\u01b0\u1ee3c c\u00f4ng nh\u1eadn l\u00e0 li\u1ec7u ph\u00e1p t\u1ed1i \u01b0u v\u00e0 hi\u1ec7u qu\u1ea3 trong \u0111i\u1ec1u tr\u1ecb b\u1ec7nh th\u1eadn IgA\" \/>\n<meta property=\"og:url\" content=\"http:\/\/noithathoaphat.in\/ctv\/index.php\/2023\/04\/22\/hieu-qua-cua-thuoc-moi-sparsentan-trong-dieu-tri-benh-than-iga\/\" \/>\n<meta property=\"og:site_name\" content=\"Vinmec\" \/>\n<meta property=\"article:published_time\" content=\"2023-04-22T15:26:49+00:00\" \/>\n<meta property=\"og:image\" content=\"http:\/\/noithathoaphat.in\/ctv\/wp-content\/uploads\/2023\/04\/Benh-than-IgA-300x175.png\" \/>\n<meta name=\"author\" content=\"Nguy\u1ec5n Ng\u1ecdc Tho\u1ea1i Nhi\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Nguy\u1ec5n Ng\u1ecdc Tho\u1ea1i Nhi\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"7 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"http:\/\/noithathoaphat.in\/ctv\/index.php\/2023\/04\/22\/hieu-qua-cua-thuoc-moi-sparsentan-trong-dieu-tri-benh-than-iga\/\",\"url\":\"http:\/\/noithathoaphat.in\/ctv\/index.php\/2023\/04\/22\/hieu-qua-cua-thuoc-moi-sparsentan-trong-dieu-tri-benh-than-iga\/\",\"name\":\"Hi\u1ec7u qu\u1ea3 c\u1ee7a thu\u1ed1c m\u1edbi Sparsentan trong \u0111i\u1ec1u tr\u1ecb b\u1ec7nh th\u1eadn IgA\",\"isPartOf\":{\"@id\":\"http:\/\/noithathoaphat.in\/ctv\/#website\"},\"datePublished\":\"2023-04-22T15:26:49+00:00\",\"dateModified\":\"2023-04-22T15:26:49+00:00\",\"author\":{\"@id\":\"http:\/\/noithathoaphat.in\/ctv\/#\/schema\/person\/55407b7fd81e248fc677fffab3aac771\"},\"description\":\"N\u1eeda \u0111\u1ea7u n\u0103m 2023 \u0111\u00e1nh d\u1ea5u b\u01b0\u1edbc ngo\u1eb7c m\u1edbi khi Sparsentan \u0111\u01b0\u1ee3c c\u00f4ng nh\u1eadn l\u00e0 li\u1ec7u ph\u00e1p t\u1ed1i \u01b0u v\u00e0 hi\u1ec7u qu\u1ea3 trong \u0111i\u1ec1u tr\u1ecb b\u1ec7nh th\u1eadn IgA\",\"breadcrumb\":{\"@id\":\"http:\/\/noithathoaphat.in\/ctv\/index.php\/2023\/04\/22\/hieu-qua-cua-thuoc-moi-sparsentan-trong-dieu-tri-benh-than-iga\/#breadcrumb\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"http:\/\/noithathoaphat.in\/ctv\/index.php\/2023\/04\/22\/hieu-qua-cua-thuoc-moi-sparsentan-trong-dieu-tri-benh-than-iga\/\"]}]},{\"@type\":\"BreadcrumbList\",\"@id\":\"http:\/\/noithathoaphat.in\/ctv\/index.php\/2023\/04\/22\/hieu-qua-cua-thuoc-moi-sparsentan-trong-dieu-tri-benh-than-iga\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"http:\/\/noithathoaphat.in\/ctv\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Hi\u1ec7u qu\u1ea3 c\u1ee7a thu\u1ed1c m\u1edbi Sparsentan trong \u0111i\u1ec1u tr\u1ecb b\u1ec7nh th\u1eadn IgA\"}]},{\"@type\":\"WebSite\",\"@id\":\"http:\/\/noithathoaphat.in\/ctv\/#website\",\"url\":\"http:\/\/noithathoaphat.in\/ctv\/\",\"name\":\"Vinmec\",\"description\":\"H\u1ec7 th\u1ed1ng Y t\u1ebf Vinmec\",\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"http:\/\/noithathoaphat.in\/ctv\/?s={search_term_string}\"},\"query-input\":\"required name=search_term_string\"}],\"inLanguage\":\"en-US\"},{\"@type\":\"Person\",\"@id\":\"http:\/\/noithathoaphat.in\/ctv\/#\/schema\/person\/55407b7fd81e248fc677fffab3aac771\",\"name\":\"Nguy\u1ec5n Ng\u1ecdc Tho\u1ea1i Nhi\",\"image\":{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"http:\/\/noithathoaphat.in\/ctv\/#\/schema\/person\/image\/\",\"url\":\"http:\/\/2.gravatar.com\/avatar\/2cb6fe9c8b954a7fbd43938a66c2c4b9?s=96&d=mm&r=g\",\"contentUrl\":\"http:\/\/2.gravatar.com\/avatar\/2cb6fe9c8b954a7fbd43938a66c2c4b9?s=96&d=mm&r=g\",\"caption\":\"Nguy\u1ec5n Ng\u1ecdc Tho\u1ea1i Nhi\"},\"url\":\"http:\/\/noithathoaphat.in\/ctv\/index.php\/author\/nguyenngocthoainhigmail-com\/\"}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"Hi\u1ec7u qu\u1ea3 c\u1ee7a thu\u1ed1c m\u1edbi Sparsentan trong \u0111i\u1ec1u tr\u1ecb b\u1ec7nh th\u1eadn IgA","description":"N\u1eeda \u0111\u1ea7u n\u0103m 2023 \u0111\u00e1nh d\u1ea5u b\u01b0\u1edbc ngo\u1eb7c m\u1edbi khi Sparsentan \u0111\u01b0\u1ee3c c\u00f4ng nh\u1eadn l\u00e0 li\u1ec7u ph\u00e1p t\u1ed1i \u01b0u v\u00e0 hi\u1ec7u qu\u1ea3 trong \u0111i\u1ec1u tr\u1ecb b\u1ec7nh th\u1eadn IgA","robots":{"index":"noindex","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"og_locale":"en_US","og_type":"article","og_title":"Hi\u1ec7u qu\u1ea3 c\u1ee7a thu\u1ed1c m\u1edbi Sparsentan trong \u0111i\u1ec1u tr\u1ecb b\u1ec7nh th\u1eadn IgA","og_description":"N\u1eeda \u0111\u1ea7u n\u0103m 2023 \u0111\u00e1nh d\u1ea5u b\u01b0\u1edbc ngo\u1eb7c m\u1edbi khi Sparsentan \u0111\u01b0\u1ee3c c\u00f4ng nh\u1eadn l\u00e0 li\u1ec7u ph\u00e1p t\u1ed1i \u01b0u v\u00e0 hi\u1ec7u qu\u1ea3 trong \u0111i\u1ec1u tr\u1ecb b\u1ec7nh th\u1eadn IgA","og_url":"http:\/\/noithathoaphat.in\/ctv\/index.php\/2023\/04\/22\/hieu-qua-cua-thuoc-moi-sparsentan-trong-dieu-tri-benh-than-iga\/","og_site_name":"Vinmec","article_published_time":"2023-04-22T15:26:49+00:00","og_image":[{"url":"http:\/\/noithathoaphat.in\/ctv\/wp-content\/uploads\/2023\/04\/Benh-than-IgA-300x175.png"}],"author":"Nguy\u1ec5n Ng\u1ecdc Tho\u1ea1i Nhi","twitter_card":"summary_large_image","twitter_misc":{"Written by":"Nguy\u1ec5n Ng\u1ecdc Tho\u1ea1i Nhi","Est. reading time":"7 minutes"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"WebPage","@id":"http:\/\/noithathoaphat.in\/ctv\/index.php\/2023\/04\/22\/hieu-qua-cua-thuoc-moi-sparsentan-trong-dieu-tri-benh-than-iga\/","url":"http:\/\/noithathoaphat.in\/ctv\/index.php\/2023\/04\/22\/hieu-qua-cua-thuoc-moi-sparsentan-trong-dieu-tri-benh-than-iga\/","name":"Hi\u1ec7u qu\u1ea3 c\u1ee7a thu\u1ed1c m\u1edbi Sparsentan trong \u0111i\u1ec1u tr\u1ecb b\u1ec7nh th\u1eadn IgA","isPartOf":{"@id":"http:\/\/noithathoaphat.in\/ctv\/#website"},"datePublished":"2023-04-22T15:26:49+00:00","dateModified":"2023-04-22T15:26:49+00:00","author":{"@id":"http:\/\/noithathoaphat.in\/ctv\/#\/schema\/person\/55407b7fd81e248fc677fffab3aac771"},"description":"N\u1eeda \u0111\u1ea7u n\u0103m 2023 \u0111\u00e1nh d\u1ea5u b\u01b0\u1edbc ngo\u1eb7c m\u1edbi khi Sparsentan \u0111\u01b0\u1ee3c c\u00f4ng nh\u1eadn l\u00e0 li\u1ec7u ph\u00e1p t\u1ed1i \u01b0u v\u00e0 hi\u1ec7u qu\u1ea3 trong \u0111i\u1ec1u tr\u1ecb b\u1ec7nh th\u1eadn IgA","breadcrumb":{"@id":"http:\/\/noithathoaphat.in\/ctv\/index.php\/2023\/04\/22\/hieu-qua-cua-thuoc-moi-sparsentan-trong-dieu-tri-benh-than-iga\/#breadcrumb"},"inLanguage":"en-US","potentialAction":[{"@type":"ReadAction","target":["http:\/\/noithathoaphat.in\/ctv\/index.php\/2023\/04\/22\/hieu-qua-cua-thuoc-moi-sparsentan-trong-dieu-tri-benh-than-iga\/"]}]},{"@type":"BreadcrumbList","@id":"http:\/\/noithathoaphat.in\/ctv\/index.php\/2023\/04\/22\/hieu-qua-cua-thuoc-moi-sparsentan-trong-dieu-tri-benh-than-iga\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"http:\/\/noithathoaphat.in\/ctv\/"},{"@type":"ListItem","position":2,"name":"Hi\u1ec7u qu\u1ea3 c\u1ee7a thu\u1ed1c m\u1edbi Sparsentan trong \u0111i\u1ec1u tr\u1ecb b\u1ec7nh th\u1eadn IgA"}]},{"@type":"WebSite","@id":"http:\/\/noithathoaphat.in\/ctv\/#website","url":"http:\/\/noithathoaphat.in\/ctv\/","name":"Vinmec","description":"H\u1ec7 th\u1ed1ng Y t\u1ebf Vinmec","potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"http:\/\/noithathoaphat.in\/ctv\/?s={search_term_string}"},"query-input":"required name=search_term_string"}],"inLanguage":"en-US"},{"@type":"Person","@id":"http:\/\/noithathoaphat.in\/ctv\/#\/schema\/person\/55407b7fd81e248fc677fffab3aac771","name":"Nguy\u1ec5n Ng\u1ecdc Tho\u1ea1i Nhi","image":{"@type":"ImageObject","inLanguage":"en-US","@id":"http:\/\/noithathoaphat.in\/ctv\/#\/schema\/person\/image\/","url":"http:\/\/2.gravatar.com\/avatar\/2cb6fe9c8b954a7fbd43938a66c2c4b9?s=96&d=mm&r=g","contentUrl":"http:\/\/2.gravatar.com\/avatar\/2cb6fe9c8b954a7fbd43938a66c2c4b9?s=96&d=mm&r=g","caption":"Nguy\u1ec5n Ng\u1ecdc Tho\u1ea1i Nhi"},"url":"http:\/\/noithathoaphat.in\/ctv\/index.php\/author\/nguyenngocthoainhigmail-com\/"}]}},"_links":{"self":[{"href":"http:\/\/noithathoaphat.in\/ctv\/index.php\/wp-json\/wp\/v2\/posts\/26766"}],"collection":[{"href":"http:\/\/noithathoaphat.in\/ctv\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"http:\/\/noithathoaphat.in\/ctv\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"http:\/\/noithathoaphat.in\/ctv\/index.php\/wp-json\/wp\/v2\/users\/54"}],"replies":[{"embeddable":true,"href":"http:\/\/noithathoaphat.in\/ctv\/index.php\/wp-json\/wp\/v2\/comments?post=26766"}],"version-history":[{"count":4,"href":"http:\/\/noithathoaphat.in\/ctv\/index.php\/wp-json\/wp\/v2\/posts\/26766\/revisions"}],"predecessor-version":[{"id":27033,"href":"http:\/\/noithathoaphat.in\/ctv\/index.php\/wp-json\/wp\/v2\/posts\/26766\/revisions\/27033"}],"wp:attachment":[{"href":"http:\/\/noithathoaphat.in\/ctv\/index.php\/wp-json\/wp\/v2\/media?parent=26766"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"http:\/\/noithathoaphat.in\/ctv\/index.php\/wp-json\/wp\/v2\/categories?post=26766"},{"taxonomy":"post_tag","embeddable":true,"href":"http:\/\/noithathoaphat.in\/ctv\/index.php\/wp-json\/wp\/v2\/tags?post=26766"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}