{"id":26630,"date":"2023-04-22T14:13:30","date_gmt":"2023-04-22T07:13:30","guid":{"rendered":"http:\/\/noithathoaphat.in\/ctv\/?p=26630"},"modified":"2023-04-22T14:13:30","modified_gmt":"2023-04-22T07:13:30","slug":"acid-hyaluronic-va-cac-ung-dung-trong-tham-my","status":"publish","type":"post","link":"http:\/\/noithathoaphat.in\/ctv\/index.php\/2023\/04\/22\/acid-hyaluronic-va-cac-ung-dung-trong-tham-my\/","title":{"rendered":"Acid hyaluronic v\u00e0 c\u00e1c \u1ee9ng d\u1ee5ng trong th\u1eabm m\u1ef9"},"content":{"rendered":"

Ng\u00e0y nay, acid hyaluronic (HA)<\/a> l\u00e0 m\u1ed9t trong nh\u1eefng th\u00e0nh ph\u1ea7n ho\u1ea1t t\u00ednh \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng r\u1ed9ng r\u00e3i nh\u1ea5t trong c\u00e1c c\u00f4ng th\u1ee9c m\u1ef9 ph\u1ea9m. Kh\u1ea3 n\u0103ng ph\u1ee5c h\u1ed3i da lu\u00f4n \u0111\u01b0\u1ee3c quan t\u00e2m b\u1edfi c\u00e1c chuy\u00ean gia v\u00e0 ng\u01b0\u1eddi ti\u00eau d\u00f9ng trong l\u0129nh v\u1ef1c n\u00e0y. C\u00f3 m\u1ed9t \u0111i\u1ec1u ch\u1eafc ch\u1eafn r\u1eb1ng da \u0111\u01b0\u1ee3c xem l\u00e0 m\u1ed9t trong nh\u1eefng ch\u1ec9 s\u1ed1 b\u00e1o hi\u1ec7u cho s\u1ee9c kh\u1ecfe c\u1ee7a m\u1ed7i ng\u01b0\u1eddi v\u00e0 HA l\u00e0 m\u1ed9t trong nh\u1eefng y\u1ebfu t\u1ed1 ch\u00ednh \u0111\u1ec3 c\u00f3 \u0111\u01b0\u1ee3c l\u00e0n m\u1ed9t l\u00e0n da kh\u1ecfe m\u1ea1nh. <\/strong><\/p>\n

1. T\u1ed5ng quan<\/h3>\n

Acid hyaluronic l\u00e0 m\u1ed9t ch\u1ea5t sinh h\u1ecdc \u0111a ph\u00e2n t\u1eed \u0111\u01b0\u1ee3c xem l\u00e0 c\u00f3 nhi\u1ec1u l\u1ee3i \u00edch theo g\u00f3c \u0111\u1ed9 khoa h\u1ecdc b\u1edbi \u1ee9ng d\u1ee5ng \u0111a d\u1ea1ng c\u1ee7a n\u00f3 trong l\u0129nh v\u1ef1c th\u1ea9m m\u1ef9 v\u00e0 sinh h\u1ecdc. C\u00e1c nghi\u00ean c\u1ee9u v\u1ec1 th\u00e0nh ph\u1ea7n n\u00e0y \u0111ang gia t\u0103ng trong nhi\u1ec1u l\u0129nh v\u1ef1c li\u00ean ng\u00e0nh nh\u1eb1m m\u1ee5c \u0111\u00edch, m\u1ed9t m\u1eb7t l\u00e0 c\u1ea3i ti\u1ebfn quy tr\u00ecnh s\u1ea3n xu\u1ea5t t\u1eeb c\u00f4ng ngh\u1ec7 sinh h\u1ecdc v\u00e0 m\u1eb7t kh\u00e1c l\u00e0 ph\u00e1t tri\u1ec3n c\u00e1c c\u00f4ng th\u1ee9c m\u1edbi k\u1ebft h\u1ee3p hyaluronan ho\u1eb7c c\u00e1c th\u00e0nh ph\u1ea7n \u0111\u1ed9t ph\u00e1 kh\u00e1c t\u1eeb HA. Nh\u1eefng n\u1ed7 l\u1ef1c khoa h\u1ecdc ng\u00e0y nay \u0111ang h\u01b0\u1edbng \u0111\u1ebfn vi\u1ec7c s\u1ea3n xu\u1ea5t s\u1ea3n ph\u1ea9m sinh h\u1ecdc \u0111a ph\u00e2n t\u1eed v\u1edbi kh\u1ed1i l\u01b0\u1ee3ng ph\u00e2n t\u1eed ph\u00f9 h\u1ee3p. Kh\u00eda c\u1ea1nh c\u1ee5 th\u1ec3 n\u00e0y ph\u1ee5 thu\u1ed9c ch\u1ee7 y\u1ebfu v\u00e0o ch\u1ee9c n\u0103ng sinh h\u1ecdc, nh\u01b0 \u0111\u01b0\u1ee3c ch\u1ec9 ra trong c\u00e1c nghi\u00ean c\u1ee9u tham kh\u1ea3o. M\u1eb7c d\u00f9 HA \u0111\u01b0\u1ee3c t\u1ed5ng h\u1ee3p t\u1eeb r\u1ea5t l\u00e2u, nh\u01b0ng ch\u00fang v\u1eabn c\u1ea7n \u0111\u01b0\u1ee3c nghi\u00ean c\u1ee9u th\u00e0nh ph\u1ea7n ho\u1ea1t t\u00ednh t\u1eeb g\u00f3c nh\u00ecn v\u1eadt l\u00fd\u2013h\u00f3a h\u1ecdc v\u00e0 sinh h\u1ecdc.<\/p>\n

\"An<\/p>\n

C\u00f4ng th\u1ee9c h\u00f3a h\u1ecdc c\u1ee7a aicd hyaluronic. Ngu\u1ed3n \u1ea3nh: ncbi.nlm.nih.gov<\/em><\/p>\n

2. Nh\u1eefng \u1ee9ng d\u1ee5ng hi\u1ec7n nay c\u1ee7a HA<\/h3>\n

HA c\u00f3 nhi\u1ec1u \u1ee9ng d\u1ee5ng d\u1ef1a tr\u00ean c\u00e1c t\u00ednh ch\u1ea5t c\u1ee5 th\u1ec3 nh\u01b0: (1) kh\u1ea3 n\u0103ng h\u00fat \u1ea9m cao; (2) t\u00ednh ch\u1ea5t \u0111\u00e0n h\u1ed3i; (3) t\u01b0\u01a1ng th\u00edch sinh h\u1ecdc; (4) kh\u00f4ng g\u00e2y d\u1ecb \u1ee9ng mi\u1ec5n d\u1ecbch. Tuy nhi\u00ean, c\u01a1 ch\u1ebf th\u1ea9m th\u1ea5u da c\u1ee7a HA v\u1eabn ch\u01b0a \u0111\u01b0\u1ee3c hi\u1ec3u r\u00f5. C\u00e1c y\u1ebfu t\u1ed1 \u0111a d\u1ea1ng \u0111\u01b0\u1ee3c nghi\u00ean c\u1ee9u, bao g\u1ed3m s\u1ef1 t\u1ed3n t\u1ea1i c\u1ee7a c\u00e1c th\u1ee5 th\u1ec3 HA trong v\u1eadn chuy\u1ec3n ch\u1ee7 \u0111\u1ed9ng v\u00e0 c\u1ea5u tr\u00fac \u0111\u1eb7c bi\u1ec7t c\u1ee7a HA c\u1ea5p \u1ea9m (hydrated HA). T\u00e1c d\u1ee5ng c\u1ea5p \u1ea9m c\u1ee7a HA c\u00f3 th\u1ec3 t\u1ed1i \u01b0u h\u00f3a s\u1ef1 h\u1ea5p th\u1ee5 c\u00e1c th\u00e0nh ph\u1ea7n ho\u1ea1t t\u00ednh v\u00e0 h\u1ed7 tr\u1ee3 l\u01b0u gi\u1eef c\u00e1c ho\u1ea1t ch\u1ea5t n\u00e0y trong l\u1edbp bi\u1ec3u b\u00ec \u0111\u01b0\u1ee3c c\u1ea5p \u1ea9m. HA l\u00e0 m\u1ed9t th\u00e0nh ph\u1ea7n th\u00edch h\u1ee3p cho c\u00e1c ch\u1ea5t sinh h\u1ecdc \u0111\u1ea1i ph\u00e2n t\u1eed v\u00ec n\u00f3 \u0111\u1ea3m b\u1ea3o t\u00ednh ch\u1ea5t \u1ed5n \u0111\u1ecbnh c\u1ee7a protein. Tuy nhi\u00ean, c\u01a1 ch\u1ebf chuy\u1ec3n h\u00f3a HA qua da v\u1eabn ch\u01b0a \u0111\u01b0\u1ee3c hi\u1ec3u r\u00f5.<\/p>\n

Trong vi\u1ec7c t\u00e1i t\u1ea1o v\u1ebft th\u01b0\u01a1ng, HA ch\u1ee7 y\u1ebfu \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng trong c\u00e1c s\u1ea3n ph\u1ea9m l\u00e0m \u0111\u1eb9p. Trong c\u00e1c c\u00f4ng th\u1ee9c d\u01b0\u1ee1ng da, HA c\u00f3 th\u1ec3 \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng nh\u01b0 m\u1ed9t th\u00e0nh ph\u1ea7n d\u01b0\u1ee1ng \u1ea9m b\u1edfi \u0111\u1eb7c t\u00ednh \u01b0a n\u01b0\u1edbc. S\u1eed d\u1ee5ng c\u00e1c s\u1ea3n ph\u1ea9m l\u00e0m \u0111\u1eb9p nh\u01b0 kem ho\u1eb7c lotion ch\u1ee9a HA gi\u00fap d\u01b0\u1ee1ng \u1ea9m cho da v\u00e0 c\u1ea3i thi\u1ec7n t\u00ednh \u0111\u00e0n h\u1ed3i c\u1ee7a da, c\u1ea3i thi\u1ec7n t\u00ecnh tr\u1ea1ng n\u1ebfp nh\u0103n. Khi \u0111\u01b0\u1ee3c b\u00f4i l\u00ean b\u1ec1 m\u1eb7t da, c\u00e1c dung d\u1ecbch HA t\u1ea1o th\u00e0nh m\u1ed9t l\u1edbp che ph\u1ee7, h\u1ea5p th\u1ee5 \u0111\u1ed9 \u1ea9m, d\u01b0\u1ee1ng \u1ea9m cho da v\u00e0 l\u00e0m m\u1edd c\u00e1c n\u1ebfp nh\u0103n. HA \u0111\u01b0\u1ee3c cho l\u00e0 k\u00edch th\u00edch s\u1ef1 di c\u01b0 c\u1ee7a c\u00e1c t\u1ebf b\u00e0o bi\u1ec3u b\u00ec. Ngo\u00e0i ra, t\u00ednh ch\u1ea5t che ph\u1ee7 c\u1ee7a HA c\u00f3 th\u1ec3 gi\u00fap c\u00e1c ch\u1ea5t ho\u1ea1t t\u00ednh sinh h\u1ecdc c\u00f3 trong c\u00e1c s\u1ea3n ph\u1ea9m l\u00e0m \u0111\u1eb9p duy tr\u00ec trong c\u00e1c l\u1edbp da v\u00e0 c\u00f3 th\u1ec3 d\u1ec5 d\u00e0ng xuy\u00ean qua bi\u1ec3u b\u00ec. Theo c\u00e1c nghi\u00ean c\u1ee9u tr\u01b0\u1edbc \u0111\u00e2y, m\u1ed9t s\u1ed1 s\u1ea3n ph\u1ea9m l\u00e0m \u0111\u1eb9p ch\u1ee9a HA \u0111\u00e3 \u0111\u01b0\u1ee3c ch\u1ee9ng minh l\u00e0 hi\u1ec7u qu\u1ea3 trong vi\u1ec7c b\u1ea3o v\u1ec7 da kh\u1ecfi tia UV. \u0110\u1ed3ng th\u1eddi, c\u00e1c s\u1ea3n ph\u1ea9m ch\u1ed1ng n\u1eafng ch\u1ee9a acid hyaluronic gi\u00fap duy tr\u00ec s\u1ef1 \u0111\u00e0n h\u1ed3i c\u1ee7a da, b\u1ea3o v\u1ec7 da kh\u1ecfi t\u00e1c \u0111\u1ed9ng \u0111\u1ed9c h\u1ea1i c\u1ee7a tia UV, nh\u1edd t\u00e1c d\u1ee5ng ch\u1ed1ng oxy h\u00f3a ti\u1ec1m n\u0103ng c\u1ee7a HA.<\/p>\n

Trong c\u00e1c c\u00f4ng th\u1ee9c m\u1ef9 ph\u1ea9m, acid hyaluronic c\u00f3 ch\u1ee9c n\u0103ng l\u00e0 m\u1ed9t ch\u1ea5t l\u00e0m thay \u0111\u1ed5i \u0111\u1ed9 nh\u1edbt ho\u1eb7c ch\u1ea5t kh\u00f3a \u1ea9m. Acid hyaluronic ch\u1ee7 y\u1ebfu \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng trong c\u00e1c s\u1ea3n ph\u1ea9m ch\u1ed1ng l\u00e3o h\u00f3a. LMW-HA c\u00f3 kh\u1ea3 n\u0103ng c\u1ea3i thi\u1ec7n \u0111\u1ed9 \u1ea9m c\u1ee7a da v\u00e0 k\u00edch th\u00edch qu\u00e1 tr\u00ecnh t\u00e1i t\u1ea1o da. HMW-HA t\u1ea1o th\u00e0nh m\u1ed9t l\u1edbp m\u00e0ng \u0111\u00e0n h\u1ed3i khi \u0111\u01b0\u1ee3c b\u00f4i l\u00ean da v\u00e0 c\u00f3 t\u00e1c d\u1ee5ng l\u00e0m d\u1ecbu nh\u1eb9 l\u00e0n da. T\u00e1c d\u1ee5ng ch\u00ednh c\u1ee7a polymer HMW-HA l\u00e0 t\u1ea1o m\u00e0ng v\u00e0 gi\u1ea3m t\u00ecnh tr\u1ea1ng tho\u00e1t h\u01a1i n\u01b0\u1edbc t\u1eeb da, do \u0111\u00f3 c\u00f3 t\u00e1c d\u1ee5ng che ph\u1ee7. Ngo\u00e0i ra, c\u00e1c t\u00ednh ch\u1ea5t h\u00fat \u1ea9m c\u1ee7a HMW-HA, MMW-HA v\u00e0 LMW-HA gi\u1ea3i th\u00edch kh\u1ea3 n\u0103ng duy tr\u00ec \u0111\u1ed9 \u1ea9m c\u1ee7a da.<\/p>\n

Acid hyaluronic c\u0169ng r\u1ea5t quan tr\u1ecdng trong vi\u1ec7c v\u1eadn chuy\u1ec3n c\u00e1c ho\u1ea1t ch\u1ea5t. Hi\u1ec7n nay, c\u00f3 m\u1ed9t s\u1ed1 s\u1ea3n ph\u1ea9m \u0111\u01b0\u1ee3c b\u00e1n tr\u00ean th\u1ecb tr\u01b0\u1eddng ch\u1ee9a c\u00e1c ho\u1ea1t ch\u1ea5t v\u1edbi n\u1ed3ng \u0111\u1ed9 kh\u00e1c nhau. Nh\u1eefng s\u1ea3n ph\u1ea9m n\u00e0y \u0111\u01b0\u1ee3c ch\u1ec9 \u0111\u1ecbnh cho vi\u1ec7c \u0111i\u1ec1u tr\u1ecb ngo\u00e0i da nh\u01b0 d\u00e0y s\u1eebng \u00e1nh s\u00e1ng v\u00e0 c\u00e1c b\u1ec7nh vi\u00eam da. Th\u1ef1c t\u1ebf \u0111\u00e3 \u0111\u01b0\u1ee3c ch\u1ee9ng minh r\u1eb1ng acid hyaluronic t\u0103ng c\u01b0\u1eddng s\u1ef1 th\u1ea9m th\u1ea5u c\u1ee7a ho\u1ea1t ch\u1ea5t qua l\u1edbp bi\u1ec3u b\u00ec da (SC), l\u00e0 l\u1edbp ch\u1eafn \u0111\u1ec3 ph\u00e2n t\u1eed kh\u00f4ng th\u1ec3 \u0111i v\u00e0o c\u00e1c t\u1ea7ng s\u00e2u h\u01a1n c\u1ee7a da, gi\u1eef v\u00e0 \u0111\u1ecbnh v\u1ecb ho\u1ea1t ch\u1ea5t trong bi\u1ec3u b\u00ec. C\u00e1c s\u1ea3n ph\u1ea9m ngo\u00e0i da ch\u1ee9a acid hyaluronic trong c\u00f4ng th\u1ee9c \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng cho t\u00ednh ch\u1ea5t ch\u1eefa l\u00e0nh, gi\u1ea3m k\u00edch \u1ee9ng da. M\u1ed9t s\u1ea3n ph\u1ea9m ngo\u00e0i da ch\u1ee9a acid hyaluronic (0,2% w\/w natri hyaluronate (NaHA)) l\u00e0 th\u00e0nh ph\u1ea7n ch\u00ednh hi\u1ec7n c\u00f3 s\u1eb5n \u0111\u1ec3 c\u1ea3i thi\u1ec7n c\u00e1c v\u1ebft th\u01b0\u01a1ng c\u1ea5p v\u00e0 m\u1ea1n t\u00ednh (v\u00f9ng da gh\u00e9p, c\u00e1c v\u1ebft c\u1eaft sau ph\u1eabu thu\u1eadt, v.v.)<\/p>\n

M\u1ed9t s\u1ed1 nghi\u00ean c\u1ee9u in vitro v\u00e0 in vivo \u0111\u00e1ng k\u1ec3 \u0111\u00e3 ch\u1ec9 ra t\u00ednh hi\u1ec7u qu\u1ea3 c\u1ee7a \u0111i\u1ec1u tr\u1ecb acid hyaluronic nh\u01b0: t\u00e1c d\u1ee5ng kh\u00e1ng vi\u00eam, t\u00e1i t\u1ea1o da v\u00e0 b\u1ea3o v\u1ec7 kh\u1edbp, t\u00e1c d\u1ee5ng ch\u1ed1ng l\u00e3o h\u00f3a v\u00e0 \u1ee9c ch\u1ebf mi\u1ec5n d\u1ecbch, v.v.<\/p>\n

M\u1eb7c d\u00f9 hyaluronan c\u00f3 nhi\u1ec1u \u1ee9ng d\u1ee5ng kh\u00e1c nhau, nh\u01b0ng v\u1eabn c\u1ea7n nh\u1eefng nghi\u00ean c\u1ee9u v\u00e0 ph\u00e1t tri\u1ec3n c\u00f4ng ngh\u1ec7 v\u1ec1 sau \u0111\u1ec3 gi\u1ea3i quy\u1ebft nh\u1eefng v\u1ea5n \u0111\u1ec1 hi\u1ec7n t\u1ea1i. \u0110\u1ea7u ti\u00ean, c\u1ea7n xem x\u00e9t th\u00eam c\u00e1c kh\u00eda c\u1ea1nh li\u00ean quan \u0111\u1ebfn s\u1ef1 trao \u0111\u1ed5i ch\u1ea5t c\u1ee7a HA v\u00e0 ph\u00e2n t\u00edch ph\u00e2n t\u1eed ch\u1ee5p k\u1ebft h\u1ee3p v\u1edbi c\u00e1c th\u1ee5 th\u1ec3 \u0111\u1ec3 gi\u1ea3i th\u00edch c\u00e1c t\u00e1c \u0111\u1ed9ng sinh h\u1ecdc kh\u00e1c nhau v\u00e0 d\u1ef1 \u0111o\u00e1n c\u00e1c t\u00e1c \u0111\u1ed9ng c\u00f3 th\u1ec3 thay \u0111\u1ed5i v\u1edbi kh\u1ed1i l\u01b0\u1ee3ng ph\u00e2n t\u1eed c\u1ee7a HA. M\u1ed9t s\u1ed1 s\u1ea3n ph\u1ea9m d\u01b0\u1ee3c ph\u1ea9m v\u00e0\/ho\u1eb7c m\u1ef9 ph\u1ea9m c\u00f3 th\u1ec3 k\u1ebft h\u1ee3p HA v\u1edbi kh\u1ed1i l\u01b0\u1ee3ng ph\u00e2n t\u1eed kh\u00e1c nhau. Do \u0111\u00f3, c\u1ea7n nghi\u00ean c\u1ee9u \u0111\u1ec3 \u0111\u00e1nh gi\u00e1 t\u00e1c \u0111\u1ed9ng c\u1ee7a kh\u1ed1i l\u01b0\u1ee3ng ph\u00e2n t\u1eed \u0111\u1ed1i v\u1edbi t\u00e1c d\u1ee5ng c\u1ee7a HA. C\u1ea7n ph\u00e1t tri\u1ec3n c\u00e1c s\u1ea3n ph\u1ea9m th\u1ebf h\u1ec7 ti\u1ebfp theo v\u1edbi c\u00e1c d\u1eabn xu\u1ea5t c\u1ee7a h\u1ec7 th\u1ed1ng giao nh\u1eadn li\u00ean k\u1ebft HA v\u00e0 ch\u1ea5t thu\u1ed1c, cung c\u1ea5p m\u1ee9c \u0111\u1ed9 t\u01b0\u01a1ng th\u00edch sinh h\u1ecdc cao, th\u1eddi gian b\u00e1n h\u1ee7y k\u00e9o d\u00e0i v\u00e0 hi\u1ec7u qu\u1ea3 l\u00e2u d\u00e0i. Do \u0111\u00f3, nh\u1eefng nghi\u00ean c\u1ee9u tr\u00ean l\u00e2m s\u00e0ng l\u00e0 c\u1ea7n thi\u1ebft \u0111\u1ec3 c\u00f3 th\u1ec3 gi\u1ea3i th\u00edch \u0111\u1ea7y \u0111\u1ee7 t\u00ednh an to\u00e0n v\u00e0 hi\u1ec7u qu\u1ea3 c\u1ee7a c\u00e1c ch\u1ea5t n\u00e0y. C\u00e1c nghi\u00ean c\u1ee9u in vitro g\u1ea7n \u0111\u00e2y \u0111\u00e3 cho th\u1ea5y k\u1ebft qu\u1ea3 h\u1ee9a h\u1eb9n v\u1ec1 s\u1ef1 an to\u00e0n v\u00e0 hi\u1ec7u qu\u1ea3 c\u1ee7a c\u00e1c h\u1ee3p ch\u1ea5t m\u1edbi v\u00e0 r\u1ea5t tri\u1ec3n v\u1ecdng n\u00e0y: v\u00ed d\u1ee5 nh\u01b0 HA-CL (urea-crosslinked hyaluronic acid) \u0111\u00e3 cho th\u1ea5y t\u00ednh t\u01b0\u01a1ng th\u00edch sinh h\u1ecdc \u0111\u00e1ng k\u1ec3 v\u1edbi t\u1ebf b\u00e0o bi\u1ec3u m\u00f4 gi\u00e1c m\u1ea1c, c\u00f3 t\u00ednh ch\u1ea5t ch\u1ed1ng oxy h\u00f3a, ch\u1ed1ng vi\u00eam v\u00e0 t\u00e1i t\u1ea1o da.<\/p>\n

HA \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng trong c\u00e1c c\u00f4ng th\u1ee9c m\u1ef9 ph\u1ea9m v\u1edbi n\u1ed3ng \u0111\u1ed9 t\u1eeb 0,2 \u0111\u1ebfn 1%. N\u1ed3ng \u0111\u1ed9 t\u1ed1i \u0111a c\u1ee7a NaHA trong m\u1ed9t s\u1ea3n ph\u1ea9m kem d\u01b0\u1ee1ng da l\u00e0 2%. Khi b\u00f4i m\u1ed9t l\u01b0\u1ee3ng ch\u1ea5t 1 mg\/cm2, l\u01b0\u1ee3ng acid hyaluronic l\u00e0 0,02 mg\/cm2 da.<\/p>\n

Vi\u1ec7c s\u1eed d\u1ee5ng acid hyaluronic nh\u01b0 m\u1ed9t th\u00e0nh ph\u1ea7n m\u1ef9 ph\u1ea9m trong c\u00e1c s\u1ea3n ph\u1ea9m ch\u0103m s\u00f3c da \u0111\u01b0\u1ee3c quan t\u00e2m \u0111\u1ebfn k\u1ec3 t\u1eeb khi ph\u00e1t hi\u1ec7n ra l\u01b0\u1ee3ng HA c\u00f3 trong da t\u1ef1 nhi\u00ean gi\u1ea3m d\u1ea7n theo tu\u1ed5i t\u00e1c v\u00e0 khi ch\u1ea5t n\u00e0y \u0111\u01b0\u1ee3c t\u00e1i gi\u1edbi thi\u1ec7u v\u00e0o c\u00e1c s\u1ea3n ph\u1ea9m ch\u0103m s\u00f3c da, n\u00f3 \u0111\u00e3 h\u1ed7 tr\u1ee3 c\u1ea5p \u1ea9m cho da, gi\u1ea3m thi\u1ec3u n\u1ebfp nh\u0103n v\u00e0 l\u00e0m m\u1ec1m da. HA c\u00f3 nhi\u1ec1u \u0111\u1eb7c t\u00ednh l\u00e0m cho n\u00f3 v\u01b0\u1ee3t tr\u1ed9i h\u01a1n so v\u1edbi c\u00e1c ch\u1ea5t kh\u00e1c \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng trong t\u00e1i t\u1ea1o da, c\u00f3 t\u00e1c d\u1ee5ng l\u00e0m \u1ea9m v\u00e0 ch\u1ed1ng l\u00e3o h\u00f3a r\u00f5 r\u1ec7t. Ho\u1ea1t t\u00ednh sinh h\u1ecdc v\u00e0 th\u1ea9m th\u1ea5u c\u1ee7a HA v\u00e0o da ph\u1ee5 thu\u1ed9c v\u00e0o kh\u1ed1i l\u01b0\u1ee3ng ph\u00e2n t\u1eed c\u1ee7a ch\u1ea5t n\u00e0y, cho th\u1ea5y c\u00e1c t\u00e1c \u0111\u1ed9ng kh\u00e1c nhau tr\u00ean da.<\/p>\n

\u0110\u00e3 \u0111\u01b0\u1ee3c m\u1ed9t s\u1ed1 nh\u00e0 nghi\u00ean c\u1ee9u ch\u1ee9ng minh r\u1eb1ng HA c\u00f3 hi\u1ec7u qu\u1ea3 m\u1ef9 ph\u1ea9m v\u00e0 dinh d\u01b0\u1ee1ng da \u0111\u00e1ng k\u1ec3 trong vi\u1ec7c c\u1ea3i thi\u1ec7n c\u00e1c nhi\u1ec1u d\u1ea1ng khuy\u1ebft \u0111i\u1ec3m da kh\u00e1c nhau nh\u01b0 n\u1ebfp nh\u0103n, v\u00f9ng da quanh m\u1eaft- c\u00e1nh m\u0169i v\u00e0 t\u00ecnh tr\u1ea1ng l\u00e3o h\u00f3a da. Nh\u1eefng t\u00e1c d\u1ee5ng k\u1ec3 tr\u00ean c\u1ee7a HA c\u00f3 li\u00ean quan \u0111\u1ebfn kh\u1ea3 n\u0103ng l\u00e0m \u0111\u1ea7y m\u00f4 m\u1ec1m, c\u1ea5p \u1ea9m cho da, k\u00edch th\u00edch collagen v\u00e0 l\u00e0m tr\u1ebb h\u00f3a khu\u00f4n m\u1eb7t.<\/p>\n

2.1. T\u00e1c d\u1ee5ng d\u01b0\u1ee1ng \u1ea9m c\u1ee7a HA trong c\u00e1c c\u00f4ng th\u1ee9c m\u1ef9 ph\u1ea9m <\/strong><\/p>\n

L\u01b0\u1ee3ng acid hyaluronic t\u1ed5ng h\u1ee3p nhi\u1ec1u h\u01a1n \u1edf bi\u1ec3u b\u00ec so v\u1edbi h\u1ea1 b\u00ec. Tuy h\u1ea1 b\u00ec d\u00e0y h\u01a1n nhi\u1ec1u so v\u1edbi bi\u1ec3u b\u00ec v\u00e0 ch\u1ee9a t\u1eeb b\u1ed1n \u0111\u1ebfn ch\u00edn l\u1ea7n l\u01b0\u1ee3ng HA nh\u01b0ng \u0111\u00e3 \u0111\u01b0\u1ee3c ch\u1ee9ng minh r\u1eb1ng cho c\u00f9ng m\u1ed9t l\u01b0\u1ee3ng m\u00f4 t\u01b0\u01a1ng \u0111\u01b0\u01a1ng, bi\u1ec3u b\u00ec t\u1ed5ng h\u1ee3p acid hyaluronic g\u1ea5p b\u1ed1n l\u1ea7n so v\u1edbi h\u1ea1 b\u00ec. Trong bi\u1ec3u b\u00ec, HA n\u1eb1m t\u1ea1i khoan gian b\u00e0o \u1edf l\u1edbp \u0111\u00e1y v\u00e0 l\u1edbp gai.<\/p>\n

T\u01b0\u01a1ng t\u1ef1 nh\u01b0 trong h\u1ea1 b\u00ec, t\u00ednh h\u00fat \u1ea9m c\u1ee7a acid hyaluronic c\u00f3 vai tr\u00f2 quan tr\u1ecdng trong vi\u1ec7c d\u01b0\u1ee1ng \u1ea9m cho c\u00e1c l\u1edbp s\u00e2u c\u1ee7a bi\u1ec3u b\u00ec, nh\u01b0ng t\u00e1c d\u1ee5ng c\u1ee7a HA kh\u00f4ng ch\u1ec9 l\u00e0 d\u01b0\u1ee1ng \u1ea9m th\u00f4ng th\u01b0\u1eddng.<\/p>\n

HA c\u00f3 kh\u1ea3 n\u0103ng li\u00ean k\u1ebft v\u1edbi n\u01b0\u1edbc l\u00ean \u0111\u1ebfn 1000 l\u1ea7n kh\u1ed1i l\u01b0\u1ee3ng c\u1ee7a n\u00f3, c\u00f3 s\u1ef1 \u0111\u00f3ng g\u00f3p quan tr\u1ecdng trong t\u0103ng tr\u01b0\u1edfng t\u1ebf b\u00e0o, k\u1ebft d\u00ednh v\u00e0 ch\u1ee9c n\u0103ng th\u1ee5 c\u1ea3m c\u1ee7a m\u00e0ng. Vai tr\u00f2 sinh h\u1ecdc ch\u00ednh c\u1ee7a HA trong khoan gian b\u00e0o l\u00e0 t\u0103ng c\u01b0\u1eddng c\u1ea5u tr\u00fac m\u00f4 k\u1ebd t\u1ebf b\u00e0o v\u00e0 s\u1ea3n xu\u1ea5t ch\u1ea5t l\u1ecfng trong khoan gian b\u00e0o c\u00f3 t\u00ednh \u0111\u00e0n h\u1ed3i cao bao, b\u1ecdc l\u1ea5y s\u1ee3i collagen v\u00e0 elastin. HA gi\u1eef \u1ea9m, cung c\u1ea5p \u0111\u1ed9 \u0111\u00e0n h\u1ed3i v\u00e0 c\u1ea3i thi\u1ec7n \u0111\u1ed9 s\u00e1ng da. HA c\u00f3 th\u1ec3 \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng t\u1ea1i ch\u1ed7 \u0111\u1ec3 t\u00e1i t\u1ea1o da v\u00e0 h\u1ed7 tr\u1ee3 d\u01b0\u1ee1ng \u1ea9m, tuy nhi\u00ean do kh\u1ed1i l\u01b0\u1ee3ng ph\u00e2n t\u1eed r\u1ea5t l\u1edbn l\u00e0m ng\u0103n ch\u1eb7n s\u1ef1 th\u1ea9m th\u1ea5u qua l\u1edbp th\u01b0\u1ee3ng b\u00ec.<\/p>\n

2.2. T\u00e1c d\u1ee5ng ch\u1ed1ng l\u00e3o h\u00f3a c\u1ee7a HA trong c\u00e1c s\u1ea3n ph\u1ea9m m\u1ef9 ph\u1ea9m<\/strong><\/p>\n

HA c\u0169ng \u0111\u00f3ng vai tr\u00f2 quan tr\u1ecdng trong vi\u1ec7c ng\u0103n ch\u1eb7n qu\u00e1 tr\u00ecnh l\u00e3o h\u00f3a c\u1ee7a da. C\u00e1c t\u1ebf b\u00e0o m\u1ea5t kh\u1ea3 n\u0103ng s\u1ea3n xu\u1ea5t HA khi l\u00e3o h\u00f3a. Da tr\u1edf n\u00ean kh\u00f4, m\u1ecfng v\u00e0 m\u1ea5t \u0111\u00e0n h\u1ed3i, g\u00e2y ra nhi\u1ec1u thay \u0111\u1ed5i \u0111\u00e1ng k\u1ec3, trong \u0111\u00f3 c\u00f3 s\u1ef1 xu\u1ea5t hi\u1ec7n c\u1ee7a n\u1ebfp nh\u0103n. L\u00e3o h\u00f3a da c\u0169ng li\u00ean quan \u0111\u1ebfn t\u00ecnh tr\u1ea1ng gi\u1ea3m \u0111\u1ed9 \u1ea9m \u1edf da. Hyaluronic acid (hyaluronan) c\u00f3 kh\u1ea3 n\u0103ng k\u1ebft n\u1ed1i v\u00e0 gi\u1eef c\u00e1c ph\u00e2n t\u1eed n\u01b0\u1edbc. Nh\u01b0 \u0111\u00e3 tr\u00ecnh b\u00e0y, HA l\u00e0 th\u00e0nh ph\u1ea7n t\u1ef1 nhi\u00ean c\u00f3 m\u1eb7t trong to\u00e0n b\u1ed9 c\u01a1 th\u1ec3. M\u1ed9t ng\u01b0\u1eddi c\u00f3 c\u00e2n n\u1eb7ng 70 kg th\u00ec c\u00f3 15g hyaluronic acid, trong \u0111\u00f3 c\u00f3 5g \u0111\u01b0\u1ee3c thay th\u1ebf h\u00e0ng ng\u00e0y. HA \u0111\u01b0\u1ee3c s\u1ea3n xu\u1ea5t t\u1ef1 nhi\u00ean v\u00e0 li\u00ean t\u1ee5c thay m\u1edbi do s\u1ef1 ph\u00e2n h\u1ee7y nhanh ch\u00f3ng c\u1ee7a n\u00f3, nh\u01b0ng s\u1ef1 thay m\u1edbi n\u00e0y c\u00f3 xu h\u01b0\u1edbng ch\u1eadm l\u1ea1i khi l\u00e3o h\u00f3a v\u00e0 ch\u1ecbu t\u00e1c \u0111\u1ed9ng t\u1eeb b\u00ean ngo\u00e0i. Do \u0111\u00f3, c\u1ea7n ph\u1ea3i h\u00e0nh \u0111\u1ed9ng r\u1ea5t s\u1edbm, duy tr\u00ec s\u1ef1 thay m\u1edbi t\u1ed1i \u01b0u c\u1ee7a hyaluronic acid, t\u01b0\u01a1ng t\u1ef1 nh\u01b0 da tr\u1ebb, \u0111\u1ec3 ng\u0103n ng\u1eeba c\u00e1c d\u1ea5u hi\u1ec7u c\u1ee7a l\u00e3o h\u00f3a.<\/p>\n

Li\u00ean quan \u0111\u1ebfn t\u00e1c \u0111\u1ed9ng sinh h\u1ecdc c\u1ee7a HA l\u00ean da, \u0111\u01b0\u1ee3c bi\u1ebft r\u1eb1ng ch\u1ea5t n\u00e0y ho\u1ea1t \u0111\u1ed9ng t\u00edch c\u1ef1c trong vi\u1ec7c t\u00edn hi\u1ec7u h\u00f3a t\u1ebf b\u00e0o da (b\u1eb1ng c\u00e1ch li\u00ean k\u1ebft v\u1edbi c\u00e1c th\u1ee5 th\u1ec3 CD44 v\u00e0 LYVE-1) v\u00e0 do \u0111\u00f3 \u1ea3nh h\u01b0\u1edfng \u0111\u1ebfn s\u1ef1 \u1ed5n \u0111\u1ecbnh c\u1ee7a ch\u1ea5t gian b\u00e0o. Ch\u00fa \u00fd r\u1eb1ng HA c\u00f3 t\u00e1c \u0111\u1ed9ng \u0111\u1ebfn s\u1ef1 ph\u00e1t tri\u1ec3n c\u1ee7a c\u00e1c t\u1ebf b\u00e0o s\u1eebng b\u1ea3o v\u1ec7 bi\u1ec3u b\u00ec kh\u1ecfi qu\u00e1 tr\u00ecnh l\u00e3o h\u00f3a. Axid hyaluronic \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng trong c\u00e1c s\u1ea3n ph\u1ea9m l\u00e0m \u0111\u1eb9p v\u00ec t\u00e1c d\u1ee5ng \u0111\u00e0n h\u1ed3i v\u00e0 t\u00e1c d\u1ee5ng l\u00ean v\u00f9ng m\u1eaft sau khi s\u1eed d\u1ee5ng li\u1ec7u ph\u00e1p l\u00e0m \u0111\u1eb9p v\u1edbi HA. Ngo\u00e0i ra, c\u1ea5u tr\u00fac li\u00ean k\u1ebft h\u00f3a h\u1ecdc k\u00e9p c\u1ee7a \u0111\u01a1n v\u1ecb D-glucuronic acid cung c\u1ea5p t\u00ednh ch\u1ea5t ch\u1ed1ng oxy h\u00f3a cho axid hyaluronic. H\u01a1n n\u1eefa, HA ki\u1ec1m ch\u1ebf s\u1ef1 ph\u00e1t tri\u1ec3n c\u1ee7a t\u1ebf b\u00e0o da th\u00f4ng qua th\u1ee5 th\u1ec3 CD44 v\u00e0 HA c\u0169ng c\u00f3 t\u00ednh ch\u1ea5t ch\u1ed1ng vi\u00eam tr\u00ean da.<\/p>\n

3. K\u1ebft lu\u1eadn<\/strong><\/h3>\n

Acid hyaluronic c\u00f3 nhi\u1ec1u t\u00e1c d\u1ee5ng trong vi\u1ec7c c\u1ea3i thi\u1ec7n l\u00e0n da, \u0111\u1eb7c bi\u1ec7t l\u00e0 t\u00e1c d\u1ee5ng d\u01b0\u1ee1ng \u1ea9m v\u00e0 kh\u1ea3 n\u0103ng ch\u1ed1ng oxy h\u00f3a \u0111\u00e3 \u0111\u01b0\u1ee3c \u1ee9ng d\u1ef1ng r\u1ed9ng r\u00e3i trong c\u00e1c s\u1ea3n ph\u1ea9m m\u1ef9 ph\u1ea9m. Tuy hi\u00ean, c\u1ea7n c\u00f3 nhi\u1ec1u nghi\u00ean c\u1ee9u trong t\u01b0\u01a1ng lai v\u1ec1 nh\u1eefng t\u00e1c d\u1ee5ng ti\u1ec1m n\u0103ng c\u1ee7a acid hyaluronic c\u0169ng nh\u01b0 c\u00e1c t\u00e1c d\u1ee5ng ph\u1ee5 c\u1ea7n l\u01b0u \u00fd khi s\u1eed d\u1ee5ng.<\/p>\n

 <\/p>\n

B\u00e0i vi\u1ebft \u0111\u01b0\u1ee3c tr\u00edch v\u00e0 d\u1ecbch t\u1eeb Advantages of Hyaluronic Acid and Its Combination with Other Bioactive Ingredients in Cosmeceuticals<\/em> – \u0111\u0103ng t\u1ea3i tr\u00ean ncbi.nlm.nih.gov th\u00e1ng 8 n\u0103m 2021.<\/p>\n","protected":false},"excerpt":{"rendered":"

Ng\u00e0y nay, acid hyaluronic (HA) l\u00e0 m\u1ed9t trong nh\u1eefng th\u00e0nh ph\u1ea7n ho\u1ea1t t\u00ednh \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng r\u1ed9ng r\u00e3i nh\u1ea5t trong c\u00e1c c\u00f4ng th\u1ee9c m\u1ef9 ph\u1ea9m. Kh\u1ea3 n\u0103ng ph\u1ee5c h\u1ed3i da lu\u00f4n \u0111\u01b0\u1ee3c quan t\u00e2m b\u1edfi c\u00e1c chuy\u00ean gia v\u00e0 ng\u01b0\u1eddi ti\u00eau d\u00f9ng trong l\u0129nh v\u1ef1c n\u00e0y. C\u00f3 m\u1ed9t \u0111i\u1ec1u ch\u1eafc ch\u1eafn r\u1eb1ng da \u0111\u01b0\u1ee3c xem […]<\/p>\n","protected":false},"author":18,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[33],"tags":[],"yoast_head":"\nAcid hyaluronic v\u00e0 c\u00e1c \u1ee9ng d\u1ee5ng trong th\u1eabm m\u1ef9 - Vinmec<\/title>\n<meta name=\"description\" content=\"Acid hyaluronic (HA) l\u00e0 m\u1ed9t trong nh\u1eefng th\u00e0nh ph\u1ea7n ho\u1ea1t t\u00ednh \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng r\u1ed9ng r\u00e3i nh\u1ea5t trong c\u00e1c c\u00f4ng th\u1ee9c m\u1ef9 ph\u1ea9m.\" \/>\n<meta name=\"robots\" content=\"noindex, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Acid hyaluronic v\u00e0 c\u00e1c \u1ee9ng d\u1ee5ng trong th\u1eabm m\u1ef9 - Vinmec\" \/>\n<meta property=\"og:description\" content=\"Acid hyaluronic (HA) l\u00e0 m\u1ed9t trong nh\u1eefng th\u00e0nh ph\u1ea7n ho\u1ea1t t\u00ednh \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng r\u1ed9ng r\u00e3i nh\u1ea5t trong c\u00e1c c\u00f4ng th\u1ee9c m\u1ef9 ph\u1ea9m.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/noithathoaphat.in\/ctv\/index.php\/2023\/04\/22\/acid-hyaluronic-va-cac-ung-dung-trong-tham-my\/\" \/>\n<meta property=\"og:site_name\" content=\"Vinmec\" \/>\n<meta property=\"article:published_time\" content=\"2023-04-22T07:13:30+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC8347214\/bin\/molecules-26-04429-g001.jpg\" \/>\n<meta name=\"author\" content=\"Tram Nguyen Le Ngoc\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Tram Nguyen Le Ngoc\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"11 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/noithathoaphat.in\/ctv\/index.php\/2023\/04\/22\/acid-hyaluronic-va-cac-ung-dung-trong-tham-my\/\",\"url\":\"https:\/\/noithathoaphat.in\/ctv\/index.php\/2023\/04\/22\/acid-hyaluronic-va-cac-ung-dung-trong-tham-my\/\",\"name\":\"Acid hyaluronic v\u00e0 c\u00e1c \u1ee9ng d\u1ee5ng trong th\u1eabm m\u1ef9 - 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