{"id":26389,"date":"2023-04-22T13:06:26","date_gmt":"2023-04-22T06:06:26","guid":{"rendered":"http:\/\/noithathoaphat.in\/ctv\/?p=26389"},"modified":"2023-04-22T13:06:26","modified_gmt":"2023-04-22T06:06:26","slug":"oxacillin-va-cefazoline-trong-dieu-tri-viem-noi-tam-mac-nhiem-khuan","status":"publish","type":"post","link":"http:\/\/noithathoaphat.in\/ctv\/index.php\/2023\/04\/22\/oxacillin-va-cefazoline-trong-dieu-tri-viem-noi-tam-mac-nhiem-khuan\/","title":{"rendered":"Oxacillin\u00a0v\u00e0 cefazoline trong \u0111i\u1ec1u tr\u1ecb vi\u00eam n\u1ed9i t\u00e2m m\u1ea1c nhi\u1ec5m khu\u1ea9n"},"content":{"rendered":"

Oxacillin v\u00e0 cefazoline l\u00e0 kh\u00e1ng sinh th\u01b0\u1eddng \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng trong qu\u00e1 tr\u00ecnh \u0111i\u1ec1u tr\u1ecb vi\u00eam n\u1ed9i t\u00e2m m\u1ea1c nhi\u1ec5m khu\u1ea9n<\/a>. B\u00e0i vi\u1ebft d\u01b0\u1edbi \u0111\u00e2y \u0111\u1ec1 c\u1eadp \u0111\u1ebfn 2 lo\u1ea1i kh\u00e1ng sinh quan tr\u1ecdng:<\/strong><\/p>\n

\"Vi\u00eam<\/p>\n

Vi\u00eam n\u1ed9i t\u00e2m m\u1ea1c nhi\u1ec5m khu\u1ea9n tr\u00ean si\u00eau \u00e2m<\/strong><\/p>\n

1.Oxacillin<\/h2>\n

1.1 L\u1ecbch s\u1eed<\/strong><\/h3>\n

\u0110\u00e2y l\u00e0 kh\u00e1ng sinh thu\u1ed9c nh\u00f3m isoxazolyl penicillin c\u00f3 \u0111\u1eb7c \u0111i\u1ec3m \u0111\u1ec1 kh\u00e1ng v\u1edbi beta-lactamase c\u1ee7a t\u1ee5 c\u1ea7u. Thu\u1ed1c \u0111\u01b0\u1ee3c \u0111\u0103ng k\u00fd b\u1eb1ng s\u00e1ng ch\u1ebf t\u1eeb n\u0103m 1960 v\u00e0 \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng t\u1eadp trung \u0111\u1ec3 \u0111i\u1ec1u tr\u1ecb t\u1ee5 c\u1ea7u t\u1eeb n\u0103m 1962. Methicillin c\u0169ng l\u00e0 penicillin b\u00e1n t\u1ed5ng h\u1ee3p nh\u01b0ng kh\u00f4ng c\u00f2n d\u00f9ng tr\u00ean l\u00e2m s\u00e0ng do \u0111\u1ed9c t\u00ednh m\u00e0 ch\u1ec9 d\u00f9ng trong l\u0129nh v\u1ef1c x\u00e9t nghi\u1ec7m m\u1ee9c \u0111\u1ed9 nh\u1ea1y c\u1ea3m c\u1ee7a t\u1ee5 c\u1ea7u.<\/p>\n

1.2. D\u01b0\u1ee3c l\u1ef1c h\u1ecdc v\u00e0 d\u01b0\u1ee3c \u0111\u1ed9ng h\u1ecdc<\/h3>\n

Ph\u1ed5 kh\u00e1ng khu\u1ea9n c\u1ee7a thu\u1ed1c l\u00e0 t\u1ee5 c\u1ea7u v\u00e0ng nh\u1ea1y c\u1ea3m v\u1edbi methicillin (MSSA), S. epidermidis, S. lugdunensis v\u00e0 c\u00e1c t\u1ee5 c\u1ea7u kh\u00f4ng sinh coagulase c\u00f2n nh\u1ea1y c\u1ea3m. Ngo\u00e0i ra thu\u1ed1c c\u0169ng c\u00f3 t\u00e1c d\u1ee5ng v\u1edbi ph\u1ebf c\u1ea7u v\u00e0 li\u00ean c\u1ea7u. C\u01a1 ch\u1ebf t\u00e1c d\u1ee5ng c\u0169ng l\u00e0 \u1ee9c ch\u1ebf t\u1ed5ng h\u1ee3p v\u00e1ch vi khu\u1ea9n nh\u01b0 c\u00e1c thu\u1ed1c beta-lactam kh\u00e1c. N\u1ed3ng \u0111\u1ed9 \u0111\u1ec9nh huy\u1ebft thanh \u0111\u1ea1t \u0111\u01b0\u1ee3c sau ti\u00eam b\u1eafp 30 ph\u00fat, sau ti\u00eam t\u0129nh m\u1ea1ch 5 ph\u00fat.
\nPh\u00e2n b\u1ed1 \u0111\u01b0\u1ee3c t\u1edbi d\u1ecbch m\u1eadt, n\u01b0\u1edbc \u1ed1i v\u00e0 d\u1ecbch m\u00e0ng ph\u1ed5i, nh\u01b0ng ch\u1ec9 \u0111\u1ea1t \u0111\u01b0\u1ee3c n\u1ed3ng \u0111\u1ed9 kh\u00f4ng \u0111\u00e1ng k\u1ec3 trong d\u1ecbch n\u00e3o t\u1ee7y v\u00e0 th\u1ee7y d\u1ecbch c\u1ee7a m\u1eaft. G\u1eafn protein huy\u1ebft thanh t\u1edbi 94% (ch\u1ee7 y\u1ebfu g\u1eafn albumin).
\nTh\u1eddi gian b\u00e1n th\u1ea3i 20-30 ph\u00fat, k\u00e9o d\u00e0i khi suy th\u1eadn. \u1ede tr\u1ebb s\u01a1 sinh 8-15 ng\u00e0y, th\u1eddi gian n\u00e0y l\u00e0 1,6h c\u00f2n \u1edf tr\u1ebb nh\u1ecf d\u01b0\u1edbi 2 tu\u1ed5i th\u1eddi gian b\u00e1n th\u1ea3i l\u00e0 0,9-1,8h.
\nThu\u1ed1c chuy\u1ec3n h\u00f3a qua gan v\u00e0 th\u1ea3i tr\u1eeb qua n\u01b0\u1edbc ti\u1ec3u v\u00e0 d\u1ecbch m\u1eadt (d\u01b0\u1edbi d\u1ea1ng thu\u1ed1c kh\u00f4ng bi\u1ebfn \u0111\u1ed5i).<\/p>\n

1.3. Ch\u1ec9 \u0111\u1ecbnh, ch\u1ed1ng ch\u1ec9 \u0111\u1ecbnh, li\u1ec1u d\u00f9ng, c\u00e1ch d\u00f9ng<\/h3>\n

VNTMNK do t\u1ee5 c\u1ea7u v\u00e0ng nh\u1ea1y methicillin (MSSA): 12 g\/24h ti\u00eam t\u0129nh m\u1ea1ch ch\u1eadm ho\u1eb7c truy\u1ec1n t\u0129nh m\u1ea1ch. \u0110\u1ed1i v\u1edbi van t\u1ef1 nhi\u00ean chia \u0111\u1ec1u 4-6 l\u1ea7n\/24h d\u00f9ng trong 2 tu\u1ea7n n\u1ebfu t\u1ed5n th\u01b0\u01a1ng tim ph\u1ea3i kh\u00f4ng bi\u1ebfn ch\u1ee9ng, trong 6 tu\u1ea7n n\u1ebfu t\u1ed5n th\u01b0\u01a1ng tim ph\u1ea3i c\u00f3 bi\u1ebfn ch\u1ee9ng ho\u1eb7c t\u1ed5n th\u01b0\u01a1ng tim tr\u00e1i. \u0110\u1ed1i v\u1edbi van nh\u00e2n t\u1ea1o chia \u0111\u1ec1u 6 l\u1ea7n\/24h \u0111i\u1ec1u tr\u1ecb k\u1ebft h\u1ee3p v\u1edbi rifampicin trong \u00edt nh\u1ea5t 6 tu\u1ea7n, trong \u0111\u00f3 2 tu\u1ea7n \u0111\u1ea7u k\u1ebft h\u1ee3p th\u00eam v\u1edbi gentamicin.
\nKh\u00f4ng n\u00ean s\u1eed d\u1ee5ng oxacillin cho nh\u1eefng tr\u01b0\u1eddng h\u1ee3p vi khu\u1ea9n nh\u1ea1y c\u1ea3m c\u00f3 th\u1ec3 \u0111i\u1ec1u tr\u1ecb \u0111\u01b0\u1ee3c b\u1eb1ng penicillin G ho\u1eb7c ampicillin.<\/p>\n

1.4. T\u00e1c d\u1ee5ng ph\u1ee5 v\u00e0 x\u1eed tr\u00ed<\/h3>\n

N\u00ean ti\u00eam ch\u1eadm (trong v\u00f2ng 30 ph\u00fat) tr\u00ean \u0111\u01b0\u1eddng truy\u1ec1n c\u00f3 s\u1eb5n \u0111\u1ec3 gi\u1ea3m thi\u1ec3u nguy c\u01a1 vi\u00eam t\u0129nh m\u1ea1ch quanh v\u1ecb tr\u00ed ti\u00eam truy\u1ec1n.
\nD\u00f9ng li\u1ec1u cao c\u00f3 th\u1ec3 xu\u1ea5t hi\u1ec7n t\u1ed5n th\u01b0\u01a1ng gan. Men gan th\u01b0\u1eddng t\u0103ng sau \u0111i\u1ec1u tr\u1ecb v\u00e0i ng\u00e0y v\u00e0 gi\u1ea3m xu\u1ed1ng sau khi ng\u1eebng \u0111i\u1ec1u tr\u1ecb.<\/p>\n

1.5. \u00dd ngh\u0129a l\u00e2m s\u00e0ng<\/h3>\n

Do methicillin g\u1eafn li\u1ec1n v\u1edbi t\u1ee5 c\u1ea7u nh\u01b0 m\u1ed9t ch\u1ec9 \u0111i\u1ec3m nh\u1ea1y c\u1ea3m kh\u00e1ng sinh, nhi\u1ec1u th\u1ea7y thu\u1ed1c \u01b0a d\u00f9ng oxacillin h\u01a1n c\u00e1c beta-lactam kh\u00e1c \u0111\u1ec3 \u0111i\u1ec1u tr\u1ecb t\u1ee5 c\u1ea7u. Tuy v\u1eady, tr\u00ean l\u00e2m s\u00e0ng c\u00f2n nhi\u1ec1u l\u1ef1a ch\u1ecdn beta-lactam thay th\u1ebf kh\u00e1c cho oxacillin, v\u00ed d\u1ee5 nh\u01b0 c\u00e1c cephalosporine.<\/p>\n

1.Cefazolin<\/h2>\n

2.1. L\u1ecbch s\u1eed<\/strong><\/h3>\n

Cefazoline l\u00e0 kh\u00e1ng sinh cephalosporine th\u1ebf h\u1ec7 1 \u0111\u0103ng k\u00fd b\u1eb1ng s\u00e1ng ch\u1ebf t\u1eeb n\u0103m 1967 v\u00e0 l\u01b0u h\u00e0nh th\u1ecb tr\u01b0\u1eddng t\u1eeb n\u0103m 1971.<\/p>\n

2.2. D\u01b0\u1ee3c l\u1ef1c h\u1ecdc v\u00e0 d\u01b0\u1ee3c \u0111\u1ed9ng h\u1ecdc<\/h3>\n

Ph\u1ed5 kh\u00e1ng khu\u1ea9n ch\u1ee7 y\u1ebfu l\u00e0 c\u00e1c c\u1ea7u khu\u1ea9n Gram d\u01b0\u01a1ng nh\u01b0 t\u1ee5 c\u1ea7u, li\u00ean c\u1ea7u (kh\u00f4ng t\u00e1c d\u1ee5ng v\u1edbi MRSA v\u00e0 c\u00e1c Enterococcus) nh\u01b0ng thu\u1ed1c c\u0169ng c\u00f3 t\u00e1c d\u1ee5ng \u0111\u1ed1i v\u1edbi m\u1ed9t s\u1ed1 tr\u1ef1c khu\u1ea9n Gram \u00e2m nh\u01b0 Escherichia coli, Proteus mirabilis v\u00e0 Klebsiella sp. C\u01a1 ch\u1ebf t\u00e1c d\u1ee5ng ng\u0103n ch\u1eb7n qu\u00e1 tr\u00ecnh t\u1ed5ng h\u1ee3p v\u00e1ch c\u1ee7a vi khu\u1ea9n khi\u1ebfn vi khu\u1ea9n ly gi\u1ea3i.
\nThu\u1ed1c d\u00f9ng \u0111\u01b0\u1eddng ti\u00eam v\u1edbi th\u1eddi gian \u0111\u1ea1t n\u1ed3ng \u0111\u1ed9 \u0111\u1ec9nh huy\u1ebft thanh sau ti\u00eam b\u1eafp 0,5-2h, sau ti\u00eam t\u0129nh m\u1ea1ch 5 ph\u00fat.
\nThu\u1ed1c ph\u00e2n b\u1ed1 t\u1ed1t \u0111\u1ebfn nhi\u1ec1u m\u00f4 c\u01a1 th\u1ec3 nh\u01b0 t\u00fai m\u1eadt, gan, th\u1eadn, x\u01b0\u01a1ng, \u0111\u1eddm, d\u1ecbch m\u1eadt, d\u1ecbch m\u00e0ng ph\u1ed5i v\u00e0 d\u1ecbch kh\u1edbp. Tuy nhi\u00ean ng\u1ea5m d\u1ecbch n\u00e3o t\u1ee7y k\u00e9m.
\nTh\u1eddi gian b\u00e1n th\u1ea3i 1,8-2h, k\u00e9o d\u00e0i khi suy th\u1eadn. \u1ede tr\u1ebb s\u01a1 sinh th\u1eddi gian n\u00e0y l\u00e0 3 \u0111\u1ebfn 5h.
\nTh\u1ea3i tr\u1eeb qua n\u01b0\u1edbc ti\u1ec3u v\u1edbi 70-80% l\u00e0 \u1edf d\u1ea1ng kh\u00f4ng bi\u1ebfn \u0111\u1ed5i.<\/p>\n

2.3. Ch\u1ec9 \u0111\u1ecbnh, ch\u1ed1ng ch\u1ec9 \u0111\u1ecbnh, li\u1ec1u d\u00f9ng, c\u00e1ch d\u00f9ng<\/h3>\n

VNTMNK do t\u1ee5 c\u1ea7u nh\u1ea1y c\u1ea3m methicillin: 2g m\u1ed7i 8h ti\u00eam t\u0129nh m\u1ea1ch ch\u1eadm ho\u1eb7c truy\u1ec1n t\u0129nh m\u1ea1ch. \u0110\u1ed1i v\u1edbi van t\u1ef1 nhi\u00ean \u0111i\u1ec1u tr\u1ecb trong 6 tu\u1ea7n. Tr\u01b0\u1eddng h\u1ee3p van nh\u00e2n t\u1ea1o \u0111i\u1ec1u tr\u1ecb k\u1ebft h\u1ee3p rifampicin trong \u00edt nh\u1ea5t 6 tu\u1ea7n, trong \u0111\u00f3 2 tu\u1ea7n \u0111\u1ea7u k\u1ebft h\u1ee3p th\u00eam gentamicin.
\nKh\u00f4ng n\u00ean d\u00f9ng cefazoline khi \u0111\u1ed3ng th\u1eddi c\u0169ng c\u00f3 nhi\u1ec5m tr\u00f9ng h\u1ec7 th\u1ea7n kinh trung \u01b0\u01a1ng (v\u00ed d\u1ee5 \u00e1p xe n\u00e3o).
\n\u0110i\u1ec1u ch\u1ec9nh li\u1ec1u d\u00f9ng khi suy th\u1eadn:<\/p>\n

    \n
  • M\u1ee9c l\u1ecdc c\u1ea7u th\u1eadn > 50 mL\/ph\u00fat: kh\u00f4ng c\u1ea7n \u0111i\u1ec1u ch\u1ec9nh li\u1ec1u<\/li>\n
  • M\u1ee9c l\u1ecdc c\u1ea7u th\u1eadn 10-50 mL\/ph\u00fat: gi\u00e3n kho\u1ea3ng c\u00e1ch li\u1ec1u d\u00f9ng m\u1ed7i 12h<\/li>\n
  • M\u1ee9c l\u1ecdc c\u1ea7u th\u1eadn < 10 mL\/ph\u00fat: gi\u00e3n kho\u1ea3ng c\u00e1ch li\u1ec1u d\u00f9ng m\u1ed7i 24h<\/li>\n<\/ul>\n

    2.4. T\u00e1c d\u1ee5ng ph\u1ee5 v\u00e0 x\u1eed tr\u00ed<\/h3>\n

    Cefazoline kh\u00f4ng c\u00f3 c\u00f9ng chu\u1ed7i nh\u00e1nh v\u1edbi c\u00e1c kh\u00e1ng sinh beta-lactam kh\u00e1c n\u00ean nguy c\u01a1 d\u1ecb \u1ee9ng ch\u00e9o v\u1edbi penicillin c\u0169ng nh\u01b0 c\u00e1c beta-lactam kh\u00e1c l\u00e0 r\u1ea5t th\u1ea5p.<\/p>\n

    2.5. \u00dd ngh\u0129a l\u00e2m s\u00e0ng<\/h3>\n

    \u0110\u1ed1i v\u1edbi VNTMNK do t\u1ee5 c\u1ea7u nh\u1ea1y c\u1ea3m methicillin kh\u00f4ng c\u00f3 di b\u1ec7nh h\u1ec7 th\u1ea7n kinh trung \u01b0\u01a1ng th\u00ec cefazoline l\u00e0 m\u1ed9t l\u1ef1a ch\u1ecdn h\u1ee3p l\u00fd. Kh\u1ea3 n\u0103ng s\u1eb5n c\u00f3 cefazoline c\u00f2n \u0111\u01b0\u1ee3c t\u0103ng th\u00eam khi thu\u1ed1c \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng r\u1ed9ng r\u00e3i trong \u0111i\u1ec1u tr\u1ecb d\u1ef1 ph\u00f2ng ph\u1eabu thu\u1eadt. Kho\u1ea3ng c\u00e1ch 8h gi\u1eefa c\u00e1c l\u1ea7n d\u00f9ng thu\u1ed1c gi\u00fap \u0111\u1ea3m b\u1ea3o vi\u1ec7c th\u1ef1c hi\u1ec7n thu\u1ed1c d\u1ec5 d\u00e0ng h\u01a1n trong \u0111i\u1ec1u ki\u1ec7n ngu\u1ed3n l\u1ef1c h\u1ea1n ch\u1ebf.<\/p>\n

    3.T\u1ed5ng k\u1ebft<\/h2>\n
      \n
    • Vi\u00eam n\u1ed9i t\u00e2m m\u1ea1c l\u00e0 m\u1ed9t trong nh\u1eefng b\u1ec7nh l\u00fd nguy hi\u1ec3m v\u00e0 kh\u00f3 \u0111i\u1ec1u tr\u1ecb. Vi\u1ec7c ch\u1ecdn thu\u1ed1c kh\u00e1ng sinh ph\u00f9 h\u1ee3p l\u00e0 r\u1ea5t quan tr\u1ecdng trong qu\u00e1 tr\u00ecnh \u0111i\u1ec1u tr\u1ecb. Oxacillin v\u00e0 Cefazoline l\u00e0 hai lo\u1ea1i kh\u00e1ng sinh \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng kh\u00e1 ph\u1ed5 bi\u1ebfn trong \u0111i\u1ec1u tr\u1ecb vi\u00eam n\u1ed9i t\u00e2m m\u1ea1c nhi\u1ec5m khu\u1ea9n.<\/li>\n
    • Oxacillin l\u00e0 m\u1ed9t lo\u1ea1i kh\u00e1ng sinh thu\u1ed9c nh\u00f3m penicillin, c\u00f3 ho\u1ea1t t\u00ednh \u0111\u1ed1i v\u1edbi c\u00e1c vi khu\u1ea9n d\u01b0\u01a1ng t\u00ednh nh\u01b0 Staphylococcus aureus. Tuy nhi\u00ean, oxacillin kh\u00f4ng ho\u1ea1t \u0111\u1ed9ng v\u1edbi c\u00e1c vi khu\u1ea9n Gram \u00e2m. Cefazoline l\u00e0 m\u1ed9t lo\u1ea1i kh\u00e1ng sinh thu\u1ed9c nh\u00f3m cephalosporin, c\u00f3 ho\u1ea1t t\u00ednh r\u1ed9ng \u0111\u1ed1i v\u1edbi c\u1ea3 vi khu\u1ea9n Gram d\u01b0\u01a1ng v\u00e0 Gram \u00e2m.<\/li>\n
    • Trong \u0111i\u1ec1u tr\u1ecb vi\u00eam n\u1ed9i t\u00e2m m\u1ea1c nhi\u1ec5m khu\u1ea9n, vi\u1ec7c s\u1eed d\u1ee5ng oxacillin v\u00e0 cefazoline t\u00f9y thu\u1ed9c v\u00e0o lo\u1ea1i vi khu\u1ea9n g\u00e2y ra nhi\u1ec5m tr\u00f9ng. N\u1ebfu vi khu\u1ea9n g\u00e2y ra nhi\u1ec5m tr\u00f9ng l\u00e0 Staphylococcus aureus, oxacillin s\u1ebd l\u00e0 l\u1ef1a ch\u1ecdn ph\u00f9 h\u1ee3p. Tuy nhi\u00ean, n\u1ebfu vi khu\u1ea9n g\u00e2y ra nhi\u1ec5m tr\u00f9ng l\u00e0 Gram \u00e2m, cefazoline s\u1ebd \u0111\u01b0\u1ee3c \u01b0u ti\u00ean l\u1ef1a ch\u1ecdn.<\/li>\n
    • T\u1ed5ng k\u1ebft l\u1ea1i, vi\u1ec7c s\u1eed d\u1ee5ng oxacillin v\u00e0 cefazoline trong \u0111i\u1ec1u tr\u1ecb vi\u00eam n\u1ed9i t\u00e2m m\u1ea1c nhi\u1ec5m khu\u1ea9n l\u00e0 ph\u00f9 h\u1ee3p. Tuy nhi\u00ean, vi\u1ec7c l\u1ef1a ch\u1ecdn lo\u1ea1i kh\u00e1ng sinh ph\u00f9 h\u1ee3p c\u1ea7n \u0111\u01b0\u1ee3c c\u00e2n nh\u1eafc k\u1ef9 l\u01b0\u1ee1ng \u0111\u1ec3 \u0111\u1ea3m b\u1ea3o hi\u1ec7u qu\u1ea3 cao nh\u1ea5t trong qu\u00e1 tr\u00ecnh \u0111i\u1ec1u tr\u1ecb.<\/li>\n<\/ul>\n","protected":false},"excerpt":{"rendered":"

      Oxacillin v\u00e0 cefazoline l\u00e0 kh\u00e1ng sinh th\u01b0\u1eddng \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng trong qu\u00e1 tr\u00ecnh \u0111i\u1ec1u tr\u1ecb vi\u00eam n\u1ed9i t\u00e2m m\u1ea1c nhi\u1ec5m khu\u1ea9n. B\u00e0i vi\u1ebft d\u01b0\u1edbi \u0111\u00e2y \u0111\u1ec1 c\u1eadp \u0111\u1ebfn 2 lo\u1ea1i kh\u00e1ng sinh quan tr\u1ecdng: Vi\u00eam n\u1ed9i t\u00e2m m\u1ea1c nhi\u1ec5m khu\u1ea9n tr\u00ean si\u00eau \u00e2m 1.Oxacillin 1.1 L\u1ecbch s\u1eed \u0110\u00e2y l\u00e0 kh\u00e1ng sinh thu\u1ed9c nh\u00f3m isoxazolyl penicillin […]<\/p>\n","protected":false},"author":7,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[12,33],"tags":[],"yoast_head":"\nOxacillin\u00a0v\u00e0 cefazoline trong \u0111i\u1ec1u tr\u1ecb vi\u00eam n\u1ed9i t\u00e2m m\u1ea1c nhi\u1ec5m khu\u1ea9n<\/title>\n<meta name=\"description\" content=\"Oxacillin\u00a0v\u00e0 cefazoline trong \u0111i\u1ec1u tr\u1ecb vi\u00eam n\u1ed9i t\u00e2m m\u1ea1c nhi\u1ec5m khu\u1ea9n l\u00e0 v\u1ea5n \u0111\u1ec1 quan tr\u1ecdng, b\u00e0i vi\u1ebft d\u01b0\u1edbi \u0111\u00e2y th\u00f4ng tin 2 lo\u1ea1i kh\u00e1ng sinh\" \/>\n<meta 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