{"id":25935,"date":"2023-04-22T21:39:46","date_gmt":"2023-04-22T14:39:46","guid":{"rendered":"http:\/\/noithathoaphat.in\/ctv\/?p=25935"},"modified":"2023-04-22T21:39:46","modified_gmt":"2023-04-22T14:39:46","slug":"tuong-tac-thuoc-giua-warfarin-va-ciprofloxacin","status":"publish","type":"post","link":"http:\/\/noithathoaphat.in\/ctv\/index.php\/2023\/04\/22\/tuong-tac-thuoc-giua-warfarin-va-ciprofloxacin\/","title":{"rendered":"T\u01b0\u01a1ng t\u00e1c thu\u1ed1c gi\u1eefa Warfarin v\u00e0 Ciprofloxacin"},"content":{"rendered":"<h2><b>Warfarin v\u00e0 Ciprofloxacin l\u00e0 hai lo\u1ea1i thu\u1ed1c \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng r\u1ed9ng r\u00e3i trong \u0111i\u1ec1u tr\u1ecb c\u00e1c b\u1ec7nh l\u00fd kh\u00e1c nhau. Tuy nhi\u00ean, t\u01b0\u01a1ng t\u00e1c gi\u1eefa hai lo\u1ea1i thu\u1ed1c n\u00e0y c\u00f3 th\u1ec3 \u1ea3nh h\u01b0\u1edfng \u0111\u1ebfn hi\u1ec7u qu\u1ea3 \u0111i\u1ec1u tr\u1ecb v\u00e0 g\u00e2y ra c\u00e1c t\u00e1c d\u1ee5ng ph\u1ee5 nghi\u00eam tr\u1ecdng. C\u00e1c chuy\u00ean gia y t\u1ebf c\u1ea7n h\u1ebft s\u1ee9c c\u1ea9n tr\u1ecdng khi k\u00ea \u0111\u01a1n hai lo\u1ea1i thu\u1ed1c n\u00e0y c\u00f9ng m\u1ed9t l\u00fac v\u00e0 n\u00ean theo d\u00f5i ch\u1eb7t ch\u1ebd t\u00ecnh tr\u1ea1ng s\u1ee9c kh\u1ecfe c\u1ee7a b\u1ec7nh nh\u00e2n \u0111\u1ec3 tr\u00e1nh c\u00e1c t\u00e1c d\u1ee5ng kh\u00f4ng mong mu\u1ed1n.<\/b><\/h2>\n<h2><b>1. Th\u00f4ng tin chung v\u1ec1 thu\u1ed1c Ciprofloxacin<\/b><\/h2>\n<h3><b>1.1 C\u01a1 ch\u1ebf t\u00e1c d\u1ee5ng<\/b><\/h3>\n<p><span style=\"font-weight: 400;\">Ciprofloxacin l\u00e0 m\u1ed9t kh\u00e1ng sinh b\u00e1n t\u1ed5ng h\u1ee3p, c\u00f3 ph\u1ed5 kh\u00e1ng khu\u1ea9n r\u1ed9ng, thu\u1ed9c nh\u00f3m Fluoroquinolon.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Thu\u1ed1c c\u00f3 t\u00e1c d\u1ee5ng di\u1ec7t vi khu\u1ea9n do \u1ee9c ch\u1ebf enzym DNA gyrase v\u00e0 topoisomerase IV (l\u00e0 nh\u1eefng enzym c\u1ea7n thi\u1ebft cho qu\u00e1 tr\u00ecnh t\u00e1i sinh s\u1ea3n DNA c\u1ee7a vi khu\u1ea9n), n\u00ean ng\u0103n s\u1ef1 sao ch\u00e9p c\u1ee7a chromosome khi\u1ebfn cho vi khu\u1ea9n kh\u00f4ng sinh s\u1ea3n \u0111\u01b0\u1ee3c nhanh ch\u00f3ng.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Ciprofloxacin c\u00f3 t\u00e1c d\u1ee5ng in vitro m\u1ea1nh h\u01a1n Acid nalidixic (Quinolon kh\u00f4ng fluor h\u00f3a).\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Ciprofloxacin c\u0169ng c\u00f3 t\u00e1c d\u1ee5ng v\u1edbi c\u00e1c vi khu\u1ea9n \u0111\u00e3 kh\u00e1ng l\u1ea1i kh\u00e1ng sinh thu\u1ed9c c\u00e1c nh\u00f3m kh\u00e1c (Aminoglycosid, Cephalosporin, Tetracyclin, Penicilin\u2026).\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Kh\u00f4ng nh\u01b0 c\u00e1c kh\u00e1ng sinh Beta lactam c\u00f3 t\u00e1c d\u1ee5ng m\u1ea1nh nh\u1ea5t \u0111\u1ed1i v\u1edbi vi khu\u1ea9n nh\u1ea1y c\u1ea3m \u1edf giai \u0111o\u1ea1n ph\u00e1t tri\u1ec3n nhanh (pha log), Ciprofloxacin di\u1ec7t khu\u1ea9n \u1edf c\u1ea3 giai \u0111o\u1ea1n ph\u00e1t tri\u1ec3n nhanh v\u00e0 ch\u1eadm.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">\u0110\u1ed1i v\u1edbi \u0111a s\u1ed1 vi khu\u1ea9n nh\u1ea1y c\u1ea3m, n\u1ed3ng \u0111\u1ed9 t\u1ed1i thi\u1ec3u di\u1ec7t khu\u1ea9n (MBC) c\u1ee7a Ciprofloxacin cao g\u1ea5p 1 \u2013 4 l\u1ea7n n\u1ed3ng \u0111\u1ed9 t\u1ed1i thi\u1ec3u \u1ee9c ch\u1ebf s\u1ef1 t\u0103ng tr\u01b0\u1edfng c\u1ee7a vi khu\u1ea9n (MIC); MBC \u0111\u00f4i khi cao g\u1ea5p 8 l\u1ea7n MIC.\u00a0<\/span><\/p>\n<figure id=\"attachment_26232\" aria-describedby=\"caption-attachment-26232\" style=\"width: 300px\" class=\"wp-caption aligncenter\"><img decoding=\"async\" loading=\"lazy\" class=\"size-medium wp-image-26232\" src=\"http:\/\/noithathoaphat.in\/ctv\/wp-content\/uploads\/2023\/04\/Ciprofloxacin-300x203.jpg\" alt=\"Ciprofloxacin\" width=\"300\" height=\"203\" srcset=\"http:\/\/noithathoaphat.in\/ctv\/wp-content\/uploads\/2023\/04\/Ciprofloxacin-300x203.jpg 300w, http:\/\/noithathoaphat.in\/ctv\/wp-content\/uploads\/2023\/04\/Ciprofloxacin.jpg 600w\" sizes=\"(max-width: 300px) 100vw, 300px\" \/><figcaption id=\"caption-attachment-26232\" class=\"wp-caption-text\">Ciprofloxacin<\/figcaption><\/figure>\n<p><b>1.2 Ch\u1ec9 \u0111\u1ecbnh c\u1ee7a Ciprofloxacin<\/b><\/p>\n<p><span style=\"font-weight: 400;\">Ciprofloxacin \u0111\u01b0\u1ee3c ch\u1ec9 \u0111\u1ecbnh cho c\u00e1c nhi\u1ec5m khu\u1ea9n n\u1eb7ng m\u00e0 c\u00e1c kh\u00e1ng sinh th\u00f4ng th\u01b0\u1eddng kh\u00f4ng c\u00f2n t\u00e1c d\u1ee5ng \u0111\u1ec3 tr\u00e1nh ph\u00e1t tri\u1ec3n c\u00e1c vi khu\u1ea9n kh\u00e1ng Cipofloxacin.<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Vi\u00eam \u0111\u01b0\u1eddng ti\u1ebft ni\u1ec7u tr\u00ean v\u00e0 d\u01b0\u1edbi<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Nhi\u1ec5m khu\u1ea9n \u0111\u01b0\u1eddng m\u1eadt, nh\u1eefng v\u1ebft c\u1eafn ho\u1eb7c c\u00f4n tr\u00f9ng \u0111\u1ed1t b\u1ecb <a href=\"https:\/\/www.vinmec.com\/vi\/tin-tuc\/thong-tin-suc-khoe\/nao-la-nhiem-trung\/\">nhi\u1ec5m khu\u1ea9n<\/a>, h\u1ea1 cam, vi\u00eam tuy\u1ebfn ti\u1ec1n li\u1ec7t<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Nhi\u1ec5m khu\u1ea9n x\u01b0\u01a1ng \u2013 kh\u1edbp, b\u1ec7nh x\u01a1 nang t\u1ee5y n\u1eb7ng, vi\u00eam tai \u2013 m\u0169i \u2013 h\u1ecdng (bao g\u1ed3m c\u1ea3 vi\u00eam tai ngo\u00e0i, tai gi\u1eefa v\u00e0 vi\u00eam xoang), vi\u00eam x\u01b0\u01a1ng \u2013 t\u1ee7y x\u01b0\u01a1ng<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Nhi\u1ec5m khu\u1ea9n \u1edf ng\u01b0\u1eddi c\u00f3 nguy c\u01a1 gi\u1ea3m mi\u1ec5n d\u1ecbch (b\u1ec7nh gi\u1ea3m b\u1ea1ch c\u1ea7u trung t\u00ednh \u1edf ng\u01b0\u1eddi suy gi\u1ea3m mi\u1ec5n d\u1ecbch), b\u1ec7nh than<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Vi\u00eam m\u00e0ng trong tim do nh\u00f3m vi khu\u1ea9n HACEK, vi\u00eam d\u1ea1 d\u00e0y \u2013 ru\u1ed9t bao g\u1ed3m <\/span><i><span style=\"font-weight: 400;\">Campylobacter<\/span><\/i><span style=\"font-weight: 400;\">, t\u1ea3, <\/span><i><span style=\"font-weight: 400;\">Salmonella<\/span><\/i><span style=\"font-weight: 400;\">, l\u1ef5 tr\u1ef1c tr\u00e0ng v\u00e0 vi\u00eam ru\u1ed9t do <\/span><i><span style=\"font-weight: 400;\">Yersinica<\/span><\/i><span style=\"font-weight: 400;\">, b\u1ec7nh l\u1eadu, u h\u1ea1t b\u1eb9n, vi\u00eam x\u01b0\u01a1ng ch\u1eadu, vi\u00eam ph\u00fac m\u1ea1c, d\u1ecbch h\u1ea1ch, vi\u00eam \u0111\u01b0\u1eddng h\u00f4 h\u1ea5p d\u01b0\u1edbi bao g\u1ed3m nhi\u1ec5m <\/span><i><span style=\"font-weight: 400;\">Pseudomonas<\/span><\/i><span style=\"font-weight: 400;\"> \u1edf ng\u01b0\u1eddi b\u1ecb x\u01a1 nang tuy\u1ebfn t\u1ee5y, tr\u1eeb do <\/span><i><span style=\"font-weight: 400;\">S.pneumoniae<\/span><\/i><span style=\"font-weight: 400;\">, nhi\u1ec5m <\/span><i><span style=\"font-weight: 400;\">Rickettsia<\/span><\/i><span style=\"font-weight: 400;\"> (bao g\u1ed3m s\u1ed1t Q, s\u1ed1t n\u1ed5i m\u1ee5n, s\u1ed1t Typhus), nhi\u1ec5m khu\u1ea9n huy\u1ebft, b\u1ec7nh th\u01b0\u01a1ng h\u00e0n v\u00e0 ph\u00f3 th\u01b0\u01a1ng h\u00e0n.<\/span><\/li>\n<\/ul>\n<p><span style=\"font-weight: 400;\">D\u00f9ng trong nhi\u1ec5m khu\u1ea9n da ho\u1eb7c c\u1ea5u tr\u00fac da do vi khu\u1ea9n Gram \u00e2m, m\u1eb7c d\u00f9 nh\u00f3m Fluoroquinolon c\u0169ng c\u00f3 ho\u1ea1t t\u00ednh m\u1ea1nh ch\u1ed1ng l\u1ea1i c\u00e1c vi khu\u1ea9n Gram d\u01b0\u01a1ng.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">D\u1ef1 ph\u00f2ng b\u1ec7nh n\u00e3o m\u00f4 c\u1ea7u, nhi\u1ec5m khu\u1ea9n ph\u1eabu thu\u1eadt v\u00e0 trong \u0111i\u1ec1u tr\u1ecb nhi\u1ec5m <em>Mycobacteria<\/em> kh\u00f4ng do lao.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">D\u00f9ng t\u1ea1i ch\u1ed7 trong \u0111i\u1ec1u tr\u1ecb nhi\u1ec5m khu\u1ea9n m\u1eaft v\u00e0 tai.<\/span><\/p>\n<h3><b>1.3 T\u00e1c d\u1ee5ng ph\u1ee5<\/b><\/h3>\n<p><b><i>Th\u01b0\u1eddng g\u1eb7p:<\/i><\/b><span style=\"font-weight: 400;\"> Ch\u00f3ng m\u1eb7t, m\u1ea5t ng\u1ee7, b\u1ed3n ch\u1ed3n, lo l\u1eafng, t\u00ecnh tr\u1ea1ng m\u01a1 m\u00e0ng, bu\u1ed3n n\u00f4n, n\u00f4n, ti\u00eau ch\u1ea3y, \u0111au b\u1ee5ng, kh\u00f3 ti\u00eau, ph\u00e1t ban,&#8230;<\/span><\/p>\n<p><b><i>\u00cdt g\u1eb7p:<\/i><\/b><span style=\"font-weight: 400;\"> N\u1ed5i ban, ng\u1ee9a, vi\u00eam t\u0129nh m\u1ea1ch n\u00f4ng, k\u00edch \u0111\u1ed9ng, nh\u1ecbp tim nhanh, r\u1ed1i lo\u1ea1n ti\u00eau h\u00f3a,&#8230;<\/span><\/p>\n<p><b><i>Hi\u1ebfm g\u1eb7p:<\/i><\/b><span style=\"font-weight: 400;\"> C\u01a1n co gi\u1eadt, l\u00fa l\u1eabn, r\u1ed1i lo\u1ea1n t\u00e2m th\u1ea7n, hoang t\u01b0\u1edfng, m\u1ea5t ng\u1ee7, tr\u1ea7m c\u1ea3m, lo\u1ea1n c\u1ea3m ngo\u1ea1i vi, r\u1ed1i lo\u1ea1n th\u1ecb gi\u00e1c k\u1ec3 c\u1ea3 \u1ea3o gi\u00e1c, r\u1ed1i lo\u1ea1n th\u00ednh gi\u00e1c, \u00f9 tai, r\u1ed1i lo\u1ea1n v\u1ecb gi\u00e1c v\u00e0 kh\u1ee9u gi\u00e1c, t\u0103ng \u00e1p l\u1ef1c n\u1ed9i s\u1ecd, vi\u00eam \u0111\u1ea1i tr\u00e0ng m\u00e0ng gi\u1ea3, h\u1ed9i ch\u1ee9ng da \u2013 ni\u00eam m\u1ea1c, vi\u00eam m\u1ea1ch, h\u1ed9i ch\u1ee9ng Lyell, ban \u0111\u1ecf da th\u00e0nh n\u1ed1t, ban \u0111\u1ecf \u0111a d\u1ea1ng ti\u1ebft d\u1ecbch,&#8230;<\/span><\/p>\n<h2><b>2.Th\u00f4ng tin chung v\u1ec1 thu\u1ed1c Warfarin<\/b><\/h2>\n<h3><b>2.1 C\u01a1 ch\u1ebf t\u00e1c d\u1ee5ng<\/b><\/h3>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Warfarin l\u00e0 thu\u1ed1c ch\u1ed1ng \u0111\u00f4ng m\u00e1u nh\u00f3m Coumarin.\u00a0 Warfarin ng\u0103n c\u1ea3n t\u1ed5ng h\u1ee3p m\u1ed9t s\u1ed1 y\u1ebfu t\u1ed1 \u0111\u00f4ng m\u00e1u \u1edf gan g\u1ed3m c\u00f3 y\u1ebfu t\u1ed1 II (prothrombin), VII (proconvertin), IX (y\u1ebfu t\u1ed1 Chrismas ho\u1eb7c th\u00e0nh ph\u1ea7n Thromboplastin huy\u1ebft t\u01b0\u01a1ng) v\u00e0 X (y\u1ebfu t\u1ed1 Stuart- Prower) b\u1eb1ng c\u00e1ch \u1ee9c ch\u1ebf t\u00e1i sinh vitamin K kh\u1eed, ch\u1ea5t n\u00e0y c\u1ea7n thi\u1ebft \u0111\u1ec3 gamma-carboxyl h\u00f3a m\u1ed9t s\u1ed1 ph\u1ea7n c\u00f2n l\u1ea1i c\u1ee7a acid glutamic trong protein ti\u1ec1n th\u00e2n c\u1ee7a c\u00e1c y\u1ebfu t\u1ed1 \u0111\u00f4ng m\u00e1u \u0111\u00f3. Kh\u00f4ng c\u00f3 vitamin K kh\u1eed, carboxyl h\u00f3a c\u00e1c ph\u1ea7n c\u00f2n l\u1ea1i c\u1ee7a acid glutamic \u1edf c\u00e1c y\u1ebfu t\u1ed1 \u0111\u00f4ng m\u00e1u II, VII, IX v\u00e0 X kh\u00f4ng th\u1ec3 ti\u1ebfn h\u00e0nh \u0111\u01b0\u1ee3c v\u00e0 c\u00e1c protein n\u00e0y kh\u00f4ng th\u1ec3 tr\u1edf th\u00e0nh \u0111\u01b0\u1ee3c c\u00e1c y\u1ebfu t\u1ed1 \u0111\u00f4ng m\u00e1u c\u00f3 ho\u1ea1t t\u00ednh.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Warfarin c\u0169ng \u1ee9c ch\u1ebf c\u00e1c protein C v\u00e0 S ch\u1ed1ng \u0111\u00f4ng m\u00e1u. Kh\u00f4ng gi\u1ed1ng Heparin, Warfarin kh\u00f4ng c\u00f3 t\u00e1c d\u1ee5ng ch\u1ed1ng \u0111\u00f4ng m\u00e1u in vitro.<\/span><\/li>\n<\/ul>\n<figure id=\"attachment_25169\" aria-describedby=\"caption-attachment-25169\" style=\"width: 300px\" class=\"wp-caption aligncenter\"><img decoding=\"async\" loading=\"lazy\" class=\"size-medium wp-image-25169\" src=\"http:\/\/noithathoaphat.in\/ctv\/wp-content\/uploads\/2023\/04\/Warfarin-1-300x300.png\" alt=\"Warfarin\" width=\"300\" height=\"300\" srcset=\"http:\/\/noithathoaphat.in\/ctv\/wp-content\/uploads\/2023\/04\/Warfarin-1-300x300.png 300w, http:\/\/noithathoaphat.in\/ctv\/wp-content\/uploads\/2023\/04\/Warfarin-1-150x150.png 150w, http:\/\/noithathoaphat.in\/ctv\/wp-content\/uploads\/2023\/04\/Warfarin-1.png 463w\" sizes=\"(max-width: 300px) 100vw, 300px\" \/><figcaption id=\"caption-attachment-25169\" class=\"wp-caption-text\">Warfarin<\/figcaption><\/figure>\n<h3><b>2.2 Ch\u1ec9 \u0111\u1ecbnh c\u1ee7a Warfarin\u00a0<\/b><\/h3>\n<p><span style=\"font-weight: 400;\">B\u1ec7nh tim d\u1ec5 g\u00e2y ngh\u1ebdn m\u1ea1ch:\u00a0<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">D\u1ef1 ph\u00f2ng c\u00e1c bi\u1ebfn ch\u1ee9ng huy\u1ebft kh\u1ed1i ngh\u1ebdn m\u1ea1ch do rung nh\u0129 (k\u00e9o d\u00e0i ho\u1eb7c k\u1ecbch ph\u00e1t)<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">B\u1ec7nh van hai l\u00e1 (k\u00e8m rung nh\u0129)<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Van nh\u00e2n t\u1ea1o (nh\u1ea5t l\u00e0 van nh\u00e2n t\u1ea1o th\u1ebf h\u1ec7 \u0111\u1ea7u ho\u1eb7c van c\u01a1 h\u1ecdc).<\/span><\/li>\n<\/ul>\n<p><span style=\"font-weight: 400;\">Nh\u1ed3i m\u00e1u c\u01a1 tim:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">D\u1ef1 ph\u00f2ng c\u00e1c bi\u1ebfn ch\u1ee9ng huy\u1ebft kh\u1ed1i ngh\u1ebdn m\u1ea1ch do nh\u1ed3i m\u00e1u c\u01a1 tim bi\u1ebfn ch\u1ee9ng: Huy\u1ebft kh\u1ed1i n\u1ed9i t\u00e2m m\u1ea1c, lo\u1ea1n n\u0103ng th\u1ea5t tr\u00e1i n\u1eb7ng, lo\u1ea1n v\u1eadn \u0111\u1ed9ng th\u1ea5t tr\u00e1i g\u00e2y t\u1eafc m\u1ea1ch, ti\u1ebfp n\u1ed1i Heparin.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">D\u1ef1 ph\u00f2ng nh\u1ed3i m\u00e1u c\u01a1 tim t\u00e1i ph\u00e1t, trong tr\u01b0\u1eddng h\u1ee3p kh\u00f4ng dung n\u1ea1p Aspirin.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">\u0110i\u1ec1u tr\u1ecb huy\u1ebft kh\u1ed1i t\u0129nh m\u1ea1ch s\u00e2u v\u00e0 ngh\u1ebdn m\u1ea1ch ph\u1ed5i c\u0169ng nh\u01b0 d\u1ef1 ph\u00f2ng t\u00e1i ph\u00e1t, ti\u1ebfp n\u1ed1i Heparin.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">D\u1ef1 ph\u00f2ng huy\u1ebft kh\u1ed1i t\u0129nh m\u1ea1ch v\u00e0 ngh\u1ebdn m\u1ea1ch ph\u1ed5i trong ph\u1eabu thu\u1eadt kh\u1edbp h\u00e1ng.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">D\u1ef1 ph\u00f2ng c\u1ee5c m\u00e1u \u0111\u00f4ng trong catheter.<\/span><\/li>\n<\/ul>\n<h3><b>2.3 T\u00e1c d\u1ee5ng ph\u1ee5<\/b><\/h3>\n<p><b><i>Th\u01b0\u1eddng g\u1eb7p:<\/i><\/b><span style=\"font-weight: 400;\"> Ch\u1ea3y m\u00e1u<\/span><\/p>\n<p><b><i>\u00cdt g\u1eb7p:<\/i><\/b><span style=\"font-weight: 400;\"> Ti\u00eau ch\u1ea3y, ban \u0111\u1ecf, r\u1ee5ng t\u00f3c.<\/span><\/p>\n<p><b><i>Hi\u1ebfm g\u1eb7p: <\/i><\/b><span style=\"font-weight: 400;\">Vi\u00eam m\u1ea1ch, da ho\u1ea1i t\u1eed khu tr\u00fa, c\u00f3 th\u1ec3 li\u00ean quan \u0111\u1ebf thi\u1ebfu h\u1ee5t b\u1ea9m sinh protein C ho\u1eb7c S, gan t\u1ed5n th\u01b0\u01a1ng.<\/span><\/p>\n<h2><b>3. T\u01b0\u01a1ng t\u00e1c thu\u1ed1c gi\u1eefa Ciprofloxacin v\u00e0 Warfarin<\/b><\/h2>\n<h3><b>3.1 C\u01a1 ch\u1ebf<\/b><\/h3>\n<p><span style=\"font-weight: 400;\">M\u1ed9t s\u1ed1 kh\u00e1ng sinh Quinolone \u0111\u00e3 \u0111\u01b0\u1ee3c b\u00e1o c\u00e1o l\u00e0 l\u00e0m t\u0103ng t\u00e1c d\u1ee5ng gi\u1ea3m prothrombin huy\u1ebft c\u1ee7a Warfarin v\u00e0 c\u00e1c thu\u1ed1c ch\u1ed1ng \u0111\u00f4ng m\u00e1u Coumarin kh\u00e1c. C\u01a1 ch\u1ebf ch\u00ednh x\u00e1c ch\u01b0a \u0111\u01b0\u1ee3c bi\u1ebft nh\u01b0ng c\u00f3 th\u1ec3 li\u00ean quan \u0111\u1ebfn vi\u1ec7c \u1ee9c ch\u1ebf chuy\u1ec3n h\u00f3a Coumarin v\u00e0\/ho\u1eb7c l\u00e0m c\u1ea1n ki\u1ec7t m\u1ed9t s\u1ed1 y\u1ebfu t\u1ed1 \u0111\u00f4ng m\u00e1u do \u1ee9c ch\u1ebf h\u1ec7 vi khu\u1ea9n \u0111\u01b0\u1eddng ru\u1ed9t s\u1ea3n xu\u1ea5t vitamin K. D\u1eabn \u0111\u1ebfn vi\u1ec7c s\u1eed d\u1ee5ng Ciprofloxacin c\u00f9ng v\u1edbi Warfarin d\u1ec5 b\u1ecb ch\u1ea3y m\u00e1u h\u01a1n.<\/span><\/p>\n<h3><b>3.2 T\u00e1c d\u1ee5ng ph\u1ee5 <\/b><b>c\u00f3 th\u1ec3 x\u1ea3y ra khi s\u1eed d\u1ee5ng Warfarin v\u00e0 Ciprofloxacin c\u00f9ng nhau<\/b><\/h3>\n<p><span style=\"font-weight: 400;\">B\u1ec7nh nh\u00e2n c\u00f3 b\u1ea5t k\u1ef3 d\u1ea5u hi\u1ec7u ch\u1ea3y m\u00e1u n\u00e0o sau \u0111\u00e2y:\u00a0<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">\u0110au<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">S\u01b0ng<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Nh\u1ee9c \u0111\u1ea7u<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Ch\u00f3ng m\u1eb7t<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Suy nh\u01b0\u1ee3c<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Ch\u1ea3y m\u00e1u k\u00e9o d\u00e0i do v\u1ebft c\u1eaft<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">T\u0103ng l\u01b0\u1ee3ng kinh nguy\u1ec7t<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Ch\u1ea3y m\u00e1u \u00e2m \u0111\u1ea1o<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Ch\u1ea3y m\u00e1u cam<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Ch\u1ea3y m\u00e1u n\u01b0\u1edbu r\u0103ng do \u0111\u00e1nh r\u0103ng<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Ch\u1ea3y m\u00e1u b\u1ea5t th\u01b0\u1eddng ho\u1eb7c b\u1ea7m t\u00edm<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">N\u01b0\u1edbc ti\u1ec3u \u0111\u1ecf ho\u1eb7c n\u00e2u<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Ph\u00e2n \u0111\u1ecf ho\u1eb7c \u0111en<\/span><\/li>\n<\/ul>\n<h3><b>3.3 Bi\u1ec7n ph\u00e1p x\u1eed l\u00fd<\/b><\/h3>\n<p><span style=\"font-weight: 400;\">Do kh\u1ea3 n\u0103ng t\u01b0\u01a1ng t\u00e1c \u0111\u00e1ng k\u1ec3 v\u1ec1 m\u1eb7t l\u00e2m s\u00e0ng v\u00e0 th\u1eadm ch\u00ed t\u1eed vong \u1edf nh\u1eefng b\u1ec7nh nh\u00e2n nh\u1ea1y c\u1ea3m, n\u00ean theo d\u00f5i ch\u1eb7t ch\u1ebd n\u1ebfu k\u00ea \u0111\u01a1n kh\u00e1ng sinh Quinolone trong khi \u0111i\u1ec1u tr\u1ecb b\u1eb1ng thu\u1ed1c ch\u1ed1ng \u0111\u00f4ng m\u00e1u coumarin. INR n\u00ean \u0111\u01b0\u1ee3c ki\u1ec3m tra th\u01b0\u1eddng xuy\u00ean v\u00e0 \u0111i\u1ec1u ch\u1ec9nh li\u1ec1u l\u01b0\u1ee3ng coumarin cho ph\u00f9 h\u1ee3p, \u0111\u1eb7c bi\u1ec7t sau khi b\u1eaft \u0111\u1ea7u ho\u1eb7c ng\u1eebng \u0111i\u1ec1u tr\u1ecb b\u1eb1ng Quinolone \u1edf nh\u1eefng b\u1ec7nh nh\u00e2n \u0111\u00e3 \u1ed5n \u0111\u1ecbnh v\u1edbi ch\u1ebf \u0111\u1ed9 \u0111i\u1ec1u tr\u1ecb ch\u1ed1ng \u0111\u00f4ng m\u00e1u.<\/span><\/p>\n<h3><b>3.4 M\u1ee9c \u0111\u1ed9 t\u01b0\u01a1ng t\u00e1c thu\u1ed1c gi\u1eefa Warfarin v\u00e0 Ciprofloxacin\u00a0 t\u1eeb nhi\u1ec1u ngu\u1ed3n kh\u00e1c nhau<\/b><\/h3>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Drug: Nghi\u00eam tr\u1ecdng\u00a0<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">WebMD: Nghi\u00eam tr\u1ecdng<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Medscape: Nghi\u00eam tr\u1ecdng<\/span><\/li>\n<\/ul>\n<h2><b>4. K\u1ebft lu\u1eadn t\u01b0\u01a1ng t\u00e1c thu\u1ed1c gi\u1eefa Warfarin v\u00e0 Ciprofloxacin<\/b><\/h2>\n<p><span style=\"font-weight: 400;\">T\u01b0\u01a1ng t\u00e1c thu\u1ed1c gi\u1eefa Warfarin v\u00e0 Ciprofloxacin c\u00f3 th\u1ec3 g\u00e2y ra c\u00e1c t\u00e1c d\u1ee5ng ph\u1ee5 nghi\u00eam tr\u1ecdng v\u00e0 \u1ea3nh h\u01b0\u1edfng \u0111\u1ebfn hi\u1ec7u qu\u1ea3 \u0111i\u1ec1u tr\u1ecb. Do \u0111\u00f3, c\u00e1c chuy\u00ean gia y t\u1ebf c\u1ea7n h\u1ebft s\u1ee9c c\u1ea9n tr\u1ecdng khi k\u00ea \u0111\u01a1n hai lo\u1ea1i thu\u1ed1c n\u00e0y c\u00f9ng m\u1ed9t l\u00fac v\u00e0 n\u00ean theo d\u00f5i ch\u1eb7t ch\u1ebd t\u00ecnh tr\u1ea1ng s\u1ee9c kh\u1ecfe c\u1ee7a b\u1ec7nh nh\u00e2n \u0111\u1ec3 tr\u00e1nh c\u00e1c t\u00e1c d\u1ee5ng kh\u00f4ng mong mu\u1ed1n.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Ngu\u1ed3n: D\u01b0\u1ee3c th\u01b0 Qu\u1ed1c gia Vi\u1ec7t Nam, Drug.com<\/span><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Warfarin v\u00e0 Ciprofloxacin l\u00e0 hai lo\u1ea1i thu\u1ed1c \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng r\u1ed9ng r\u00e3i trong \u0111i\u1ec1u tr\u1ecb c\u00e1c b\u1ec7nh l\u00fd kh\u00e1c nhau. Tuy nhi\u00ean, t\u01b0\u01a1ng t\u00e1c gi\u1eefa hai lo\u1ea1i thu\u1ed1c n\u00e0y c\u00f3 th\u1ec3 \u1ea3nh h\u01b0\u1edfng \u0111\u1ebfn hi\u1ec7u qu\u1ea3 \u0111i\u1ec1u tr\u1ecb v\u00e0 g\u00e2y ra c\u00e1c t\u00e1c d\u1ee5ng ph\u1ee5 nghi\u00eam tr\u1ecdng. C\u00e1c chuy\u00ean gia y t\u1ebf c\u1ea7n h\u1ebft s\u1ee9c [&hellip;]<\/p>\n","protected":false},"author":53,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[12],"tags":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v20.4 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>T\u01b0\u01a1ng t\u00e1c thu\u1ed1c gi\u1eefa Warfarin v\u00e0 Ciprofloxacin - Vinmec<\/title>\n<meta name=\"description\" content=\"Warfarin v\u00e0 Ciprofloxacin l\u00e0 hai lo\u1ea1i thu\u1ed1c \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng r\u1ed9ng r\u00e3i trong \u0111i\u1ec1u tr\u1ecb c\u00e1c b\u1ec7nh l\u00fd kh\u00e1c nhau. 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