{"id":25928,"date":"2023-04-22T10:28:44","date_gmt":"2023-04-22T03:28:44","guid":{"rendered":"http:\/\/noithathoaphat.in\/ctv\/?p=25928"},"modified":"2023-04-22T10:28:44","modified_gmt":"2023-04-22T03:28:44","slug":"tuong-tac-thuoc-giua-rifampicin-va-theophylin","status":"publish","type":"post","link":"http:\/\/noithathoaphat.in\/ctv\/index.php\/2023\/04\/22\/tuong-tac-thuoc-giua-rifampicin-va-theophylin\/","title":{"rendered":"T\u01b0\u01a1ng t\u00e1c thu\u1ed1c gi\u1eefa Rifampicin v\u00e0 Theophylin"},"content":{"rendered":"

Rifampicin v\u00e0 Theophylin l\u00e0 hai lo\u1ea1i thu\u1ed1c \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng r\u1ed9ng r\u00e3i trong \u0111i\u1ec1u tr\u1ecb c\u00e1c b\u1ec7nh l\u00fd kh\u00e1c nhau. Tuy nhi\u00ean, t\u01b0\u01a1ng t\u00e1c gi\u1eefa hai lo\u1ea1i thu\u1ed1c n\u00e0y c\u00f3 th\u1ec3 \u1ea3nh h\u01b0\u1edfng \u0111\u1ebfn hi\u1ec7u qu\u1ea3 \u0111i\u1ec1u tr\u1ecb v\u00e0 g\u00e2y ra c\u00e1c t\u00e1c d\u1ee5ng ph\u1ee5 nghi\u00eam tr\u1ecdng. C\u00e1c chuy\u00ean gia y t\u1ebf c\u1ea7n h\u1ebft s\u1ee9c c\u1ea9n tr\u1ecdng khi k\u00ea \u0111\u01a1n hai lo\u1ea1i thu\u1ed1c n\u00e0y c\u00f9ng m\u1ed9t l\u00fac v\u00e0 n\u00ean theo d\u00f5i ch\u1eb7t ch\u1ebd t\u00ecnh tr\u1ea1ng s\u1ee9c kh\u1ecfe c\u1ee7a b\u1ec7nh nh\u00e2n \u0111\u1ec3 tr\u00e1nh c\u00e1c t\u00e1c d\u1ee5ng kh\u00f4ng mong mu\u1ed1n.<\/b><\/p>\n

1. Th\u00f4ng tin chung v\u1ec1 thu\u1ed1c Rifampicin<\/b><\/h2>\n

1.1 C\u01a1 ch\u1ebf t\u00e1c d\u1ee5ng<\/b><\/h3>\n

Rifampicin l\u00e0 m\u1ed9t kh\u00e1ng sinh b\u00e1n t\u1ed5ng h\u1ee3p c\u00f3 d\u1eabn xu\u1ea5t t\u1eeb Rifamycin B. Rifampicin c\u00f3 ho\u1ea1t t\u00ednh v\u1edbi c\u00e1c vi khu\u1ea9n thu\u1ed9c ch\u1ee7ng <\/span>Mycobacterium<\/span><\/i>. Rifampicin c\u00f3 t\u00e1c d\u1ee5ng di\u1ec7t c\u00e1c tr\u1ef1c khu\u1ea9n \u0111ang t\u00edch c\u1ef1c nh\u00e2n l\u00ean v\u1ec1 s\u1ed1 l\u01b0\u1ee3ng<\/span><\/p>\n

Ngo\u00e0i ra, Rifampicin l\u00e0 1 kh\u00e1ng sinh ph\u1ed5 r\u1ed9ng, in vitro c\u00f3 t\u00e1c d\u1ee5ng<\/em> t\u1ed1t \u0111\u1ed1i v\u1edbi \u0111a s\u1ed1 vi khu\u1ea9n Gram d\u01b0\u01a1ng<\/a> v\u00e0 vi khu\u1ea9n Gram \u00e2m nh\u01b0 <\/span>E. coli<\/span>, <\/span>Pseudomonas<\/span>, <\/span>Proteus<\/span><\/em>\u00a0v\u00e0 <\/span>Klebsiella<\/span><\/i>. Rifampicin r\u1ea5t t\u00e1c d\u1ee5ng \u0111\u1ed1i v\u1edbi <\/span>Staphylococcus aureus<\/span><\/i> v\u00e0 <\/span>Staphylococcus coagulase<\/span><\/i> \u00e2m t\u00ednh n\u1ed3ng \u0111\u1ed9 di\u1ec7t khu\u1ea9n t\u1eeb 3 \u2013 12 nanogam\/ml. Thu\u1ed1c c\u0169ng r\u1ea5t t\u00e1c d\u1ee5ng \u0111\u1ed1i v\u1edbi <\/span>Neisseria meningitidis<\/span><\/i> v\u00e0 <\/span>Haemophilus influenzae<\/span><\/i>, n\u1ed3ng \u0111\u1ed9 \u1ee9c ch\u1ebf t\u1ed1i thi\u1ec3u: 0,1 \u2013 0,8 microgam\/ml. Rifampicin c\u0169ng \u1ee9c ch\u1ebf r\u1ea5t nhi\u1ec1u c\u00e1c ch\u1ee7ng <\/span>Legionella<\/span><\/i> \u1edf m\u00f4i tr\u01b0\u1eddng nu\u00f4i c\u1ea5y v\u00e0 tr\u00ean m\u00f4 h\u00ecnh s\u00fac v\u1eadt. Thu\u1ed1c \u00edt c\u00f3 t\u00e1c d\u1ee5ng \u0111\u1ed1i v\u1edbi c\u1ea7u khu\u1ea9n ru\u1ed9t v\u00e0 c\u00e1c <\/span>Enterobacteriaceae<\/span><\/i> kh\u00e1ng thu\u1ed1c.<\/span><\/p>\n

\"Rifampicin\"
Rifampicin<\/figcaption><\/figure>\n

1.2 Ch\u1ec9 \u0111\u1ecbnh<\/b><\/h3>\n

\u0110i\u1ec1u tr\u1ecb t\u1ea5t c\u1ea3 c\u00e1c th\u1ec3 lao bao g\u1ed3m c\u1ea3 lao m\u00e0ng n\u00e3o, th\u01b0\u1eddng ph\u1ea3i ph\u1ed1i h\u1ee3p v\u1edbi c\u00e1c thu\u1ed1c tr\u1ecb lao kh\u00e1c nh\u01b0 Isoniazid, Pyrazinamid, Ethambutol, Streptomycin \u0111\u1ec3 ph\u00f2ng tr\u1ef1c khu\u1ea9n \u0111\u1ed9t bi\u1ebfn kh\u00e1ng thu\u1ed1c.\u00a0<\/span><\/p>\n

\u0110i\u1ec1u tr\u1ecb phong: \u0110\u1ed1i v\u1edbi nh\u00f3m phong \u00edt vi khu\u1ea9n, theo ph\u00e1c \u0111\u1ed3 k\u1ebft h\u1ee3p 2 thu\u1ed1c, ph\u1ea3i ph\u1ed1i h\u1ee3p Rifampicin v\u1edbi thu\u1ed1c tr\u1ecb phong Dapson. \u0110\u1ed1i v\u1edbi nh\u00f3m phong nhi\u1ec1u vi khu\u1ea9n, theo ph\u00e1c \u0111\u1ed3 3 thu\u1ed1c, ph\u1ed1i h\u1ee3p Rifampicin v\u1edbi Dapson v\u00e0 Clofazimin.<\/span><\/p>\n

M\u1ed9t s\u1ed1 ch\u1ec9 \u0111\u1ecbnh kh\u00e1c:<\/span><\/p>\n

    \n
  • Ph\u00f2ng vi\u00eam m\u00e0ng n\u00e3o do <\/span>Haemophilus influenzae<\/span><\/i> v\u00e0 <\/span>Neisseria meningitidis <\/span><\/i>cho nh\u1eefng ng\u01b0\u1eddi ti\u1ebfp x\u00fac tr\u1ef1c ti\u1ebfp v\u1edbi ng\u01b0\u1eddi b\u1ec7nh ch\u1eafc ch\u1eafn ho\u1eb7c nghi m\u1eafc c\u00e1c vi khu\u1ea9n \u0111\u00f3.<\/span><\/li>\n
  • \u0110i\u1ec1u tr\u1ecb nhi\u1ec5m khu\u1ea9n n\u1eb7ng do c\u00e1c ch\u1ee7ng <\/span>Staphylococcus<\/span><\/i> k\u1ec3 c\u1ea3 c\u00e1c ch\u1ee7ng \u0111\u00e3 kh\u00e1ng methicilin v\u00e0 \u0111a kh\u00e1ng (ph\u1ed1i h\u1ee3p v\u1edbi c\u00e1c thu\u1ed1c ch\u1ed1ng t\u1ee5 c\u1ea7u). Nhi\u1ec5m <\/span>Mycobacterium<\/span><\/i> kh\u00f4ng \u0111i\u1ec3n h\u00ecnh (M<\/em><\/span>. avium<\/span><\/em>) \u1edf ng\u01b0\u1eddi b\u1ec7nh AIDS c\u0169ng ph\u1ea3i ph\u1ed1i h\u1ee3p v\u1edbi c\u00e1c thu\u1ed1c kh\u00e1ng khu\u1ea9n kh\u00e1c c\u0169ng gi\u1ed1ng nh\u01b0 \u0111i\u1ec1u tr\u1ecb lao.<\/span><\/li>\n<\/ul>\n

    1.3 T\u00e1c d\u1ee5ng ph\u1ee5<\/b><\/h3>\n

    Th\u01b0\u1eddng g\u1eb7p: <\/i><\/b>\u1ec8a ch\u1ea3y, \u0111au b\u1ee5ng, bu\u1ed3n n\u00f4n, ch\u00e1n \u0103n, ban da, ng\u1ee9a k\u00e8m theo ban da ho\u1eb7c kh\u00f4ng, r\u1ed1i lo\u1ea1n kinh nguy\u1ec7t.<\/span><\/p>\n

    \u00cdt g\u1eb7p:<\/i><\/b> \u0110au \u0111\u1ea7u, ch\u00f3ng m\u1eb7t, m\u1ec7t m\u1ecfi, s\u1ed1t, ng\u1ee7 g\u00e0, m\u1ea5t \u0111i\u1ec1u h\u00f2a, kh\u00f3 t\u1eadp trung, t\u0103ng transaminase, t\u0103ng phosphatase ki\u1ec1m, t\u0103ng bilirubin huy\u1ebft thanh, v\u00e0ng da v\u00e0 r\u1ed1i lo\u1ea1n porphyrin tho\u00e1ng qua, vi\u00eam k\u1ebft m\u1ea1c xu\u1ea5t ti\u1ebft.<\/span><\/p>\n

    Hi\u1ebfm g\u1eb7p:<\/i><\/b> R\u00e9t run, s\u1ed1t, gi\u1ea3m ti\u1ec3u c\u1ea7u, gi\u1ea3m b\u1ea1ch c\u1ea7u, t\u0103ng b\u1ea1ch c\u1ea7u \u00e1i toan v\u00e0 thi\u1ebfu m\u00e1u tan huy\u1ebft, vi\u00eam \u0111\u1ea1i tr\u00e0ng m\u00e0ng gi\u1ea3, ngo\u1ea1i ban, ban xu\u1ea5t huy\u1ebft, kh\u00f3 th\u1edf, suy th\u1eadn n\u1eb7ng, y\u1ebfu c\u01a1.<\/span><\/p>\n

    2. Th\u00f4ng tin chung v\u1ec1 thu\u1ed1c Theophylin<\/b><\/h2>\n

    2.1 C\u01a1 ch\u1ebf t\u00e1c d\u1ee5ng<\/b><\/h3>\n
      \n
    • C\u00e1c c\u01a1 ch\u1ebf t\u00e1c d\u1ee5ng d\u01b0\u1ee3c l\u00fd c\u1ee7a Theophylin \u0111\u01b0\u1ee3c \u0111\u1ec1 xu\u1ea5t bao g\u1ed3m (1) \u1ee9c ch\u1ebf phosphodiesterase, do \u0111\u00f3 l\u00e0m t\u0103ng AMP v\u00f2ng n\u1ed9i b\u00e0o, (2) t\u00e1c d\u1ee5ng tr\u1ef1c ti\u1ebfp tr\u00ean n\u1ed3ng \u0111\u1ed9 Calci n\u1ed9i b\u00e0o, (3) t\u00e1c d\u1ee5ng gi\u00e1n ti\u1ebfp tr\u00ean n\u1ed3ng \u0111\u1ed9 Calci n\u1ed9i b\u00e0o th\u00f4ng qua t\u0103ng ph\u00e2n c\u1ef1c m\u00e0ng t\u1ebf b\u00e0o, (4) \u0111\u1ed1i kh\u00e1ng th\u1ee5 th\u1ec3 adenosin, \u0111\u1ed1i kh\u00e1ng prostaglandin. Theophylin \u0111\u01b0\u1ee3c d\u00f9ng nh\u01b0 l\u00e0 m\u1ed9t thu\u1ed1c gi\u00e3n ph\u1ebf qu\u1ea3n trong x\u1eed tr\u00ed t\u1eafc ngh\u1ebdn \u0111\u01b0\u1eddng th\u1edf h\u1ed3i ph\u1ee5c \u0111\u01b0\u1ee3c, nh\u01b0 hen ph\u1ebf qu\u1ea3n. Nh\u00ecn chung thu\u1ed1c ch\u1ee7 v\u1eadn beta-2 nh\u01b0 Salbutamol l\u00e0 thu\u1ed1c l\u1ef1a ch\u1ecdn h\u00e0ng \u0111\u1ea7u trong gi\u00e3n ph\u1ebf qu\u1ea3n, Theophylin th\u01b0\u1eddng \u0111\u01b0\u1ee3c d\u00f9ng h\u1ed7 tr\u1ee3 c\u00f9ng thu\u1ed1c ch\u1ee7 v\u1eadn beta-2 v\u00e0 Corticosteroid \u1edf ng\u01b0\u1eddi b\u1ec7nh c\u1ea7n th\u00eam t\u00e1c d\u1ee5ng gi\u00e3n ph\u1ebf qu\u1ea3n. S\u1ef1 k\u1ebft h\u1ee3p n\u00e0y c\u00f3 th\u1ec3 l\u00e0m t\u0103ng m\u1ed9t s\u1ed1 t\u00e1c d\u1ee5ng kh\u00f4ng mong mu\u1ed1n nh\u01b0 h\u1ea1 Kali huy\u1ebft. M\u1ed9t v\u00e0i b\u1ec7nh nh\u00e2n b\u1ecb b\u1ec7nh ph\u1ed5i t\u1eafc ngh\u1ebdn m\u1ea1n t\u00ednh c\u0169ng \u0111\u00e1p \u1ee9ng t\u1ed1t v\u1edbi Theophylin.<\/span><\/li>\n<\/ul>\n
      \"Theophylin\"
      Theophylin<\/figcaption><\/figure>\n

      2.2 Ch\u1ec9 \u0111\u1ecbnh<\/b><\/h3>\n

      \u0110i\u1ec1u tr\u1ecb tri\u1ec7u ch\u1ee9ng v\u00e0 t\u1eafc ngh\u1ebdn \u0111\u01b0\u1eddng th\u1edf c\u00f2n h\u1ed3i ph\u1ee5c do hen m\u00e3n t\u00ednh ho\u1eb7c do c\u00e1c b\u1ec7nh ph\u1ed5i m\u1ea1n t\u00ednh kh\u00e1c:<\/span><\/p>\n

        \n
      • Theo H\u01b0\u1edbng d\u1eabn \u0111i\u1ec1u tr\u1ecb hen to\u00e0n c\u1ea7u (The Global initiative for Asthma Guidelines, 2009), kh\u00f4ng khuy\u1ebfn c\u00e1o d\u00f9ng Theophylin u\u1ed1ng l\u00e0m thu\u1ed1c \u0111i\u1ec1u tr\u1ecb l\u00e2u d\u00e0i b\u1ec7nh hen ph\u1ebf qu\u1ea3n \u1edf tr\u1ebb em \u2264 5 tu\u1ed5i; \u0111\u00e3 \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng c\u00f3 hi\u1ec7u qu\u1ea3 khi th\u00eam v\u00e0o (nh\u01b0ng kh\u00f4ng \u0111\u01b0\u1ee3c \u01b0a chu\u1ed9ng) cho tr\u1ebb l\u1edbn h\u01a1n ho\u1eb7c ng\u01b0\u1eddi l\u1edbn khi \u0111i\u1ec1u tr\u1ecb hen ph\u1ebf qu\u1ea3n n\u1eb7ng c\u00f9ng v\u1edbi thu\u1ed1c h\u00edt ho\u1eb7c u\u1ed1ng Glucocorticoid. Kh\u00f4ng khuy\u1ebfn c\u00e1o d\u00f9ng Theophylin \u0111i\u1ec1u tr\u1ecb hen ti\u1ebfn tri\u1ec3n (\u0111\u1ee3t hen n\u1eb7ng).<\/span><\/li>\n
      • C\u00f3 \u00edt ch\u1ee9ng c\u1ee9 cho th\u1ea5y Theophylin (Aminophylin) ti\u00eam t\u0129nh m\u1ea1ch c\u00f3 th\u1ec3 c\u00f3 t\u00e1c d\u1ee5ng khi d\u00f9ng th\u00eam \u1edf tr\u1ebb em n\u1eb1m \u0111i\u1ec1u tr\u1ecb trong ph\u00f2ng \u0111i\u1ec1u tr\u1ecb t\u0103ng c\u01b0\u1eddng v\u00ec \u0111\u1ee3t hen n\u1eb7ng kh\u00f4ng ki\u1ec3m so\u00e1t \u0111\u01b0\u1ee3c b\u1eb1ng c\u00e1c thu\u1ed1c ch\u1ee7 v\u1eadn beta-2 h\u00edt v\u00e0 ti\u00eam t\u0129nh m\u1ea1ch, Ipratropium bromid v\u00e0 Corticosteroid ti\u00eam t\u0129nh m\u1ea1ch; tuy v\u1eady, hi\u1ec7u qu\u1ea3 n\u00e0y ch\u01b0a \u0111\u01b0\u1ee3c x\u00e1c \u0111\u1ecbnh \u1edf ng\u01b0\u1eddi l\u1edbn. \u0110i\u1ec1u tr\u1ecb n\u00e0y kh\u00f4ng \u0111\u01b0\u1ee3c khuy\u1ebfn c\u00e1o.<\/span><\/li>\n<\/ul>\n

        B\u1ec7nh ph\u1ed5i t\u1eafc ngh\u1ebdn m\u1ea1n t\u00ednh (COPD):<\/span><\/p>\n

          \n
        • Theophylin (ch\u1ebf ph\u1ea9m u\u1ed1ng t\u00e1c d\u1ee5ng k\u00e9o d\u00e0i) c\u00f3 th\u1ec3 th\u00eam ho\u1eb7c thay th\u1ebf li\u1ec7u ph\u00e1p c\u00e1c thu\u1ed1c gi\u00e3n ph\u1ebf qu\u1ea3n t\u00e1c d\u1ee5ng k\u00e9o d\u00e0i (nh\u01b0 Tiotropium, ho\u1eb7c ch\u1ea5t ch\u1ee7 v\u1eadn ch\u1ecdn l\u1ecdc beta-2 h\u00edt) \u1edf ng\u01b0\u1eddi b\u1ec7nh b\u1ecb COPD n\u1eb7ng c\u1ea7n \u0111i\u1ec1u tr\u1ecb th\u00eam v\u00ec \u0111\u00e1p \u1ee9ng kh\u00f4ng th\u1ecfa \u0111\u00e1ng ho\u1eb7c do c\u00f3 t\u00e1c d\u1ee5ng ph\u1ee5.<\/span><\/li>\n
        • Vai tr\u00f2 c\u1ee7a Theophylin \u1edf ng\u01b0\u1eddi b\u1ec7nh b\u1ecb c\u00e1c \u0111\u1ee3t n\u1eb7ng l\u00ean c\u1ee7a COPD c\u00f2n tranh c\u00e3i. M\u1ed9t s\u1ed1chuy\u00ean gia y t\u1ebf l\u00e2m s\u00e0ng cho l\u00e0 kh\u00f4ng c\u00f3 l\u1ee3i, c\u00f3 khi c\u00f2n c\u00f3 t\u00e1c d\u1ee5ng x\u1ea5u.<\/span><\/li>\n
        • Li\u1ec1u cao ch\u1ebf ph\u1ea9m Theophylin gi\u1ea3i ph\u00f3ng ch\u1eadm tuy \u0111\u00e3 \u0111\u01b0\u1ee3c ch\u1ee9ng minh c\u00f3 t\u00e1c d\u1ee5ng trong \u0111i\u1ec1u tr\u1ecb b\u1ec7nh ph\u1ed5i t\u1eafc ngh\u1ebdn m\u1ea1n t\u00ednh, nh\u01b0ng kh\u00f4ng ph\u1ea3i l\u00e0 thu\u1ed1c \u0111\u01b0\u1ee3c \u01b0a d\u00f9ng v\u00ec c\u00f3 ti\u1ec1m n\u0103ng \u0111\u1ed9c t\u00ednh.<\/span><\/li>\n<\/ul>\n

          2.3 T\u00e1c d\u1ee5ng ph\u1ee5<\/b><\/h3>\n

          Th\u01b0\u1eddng g\u1eb7p:<\/i><\/b> Nh\u1ecbp tim nhanh, t\u00ecnh tr\u1ea1ng k\u00edch \u0111\u1ed9ng, b\u1ed3n ch\u1ed3n, bu\u1ed3n n\u00f4n, n\u00f4n.<\/span><\/p>\n

          \u00cdt g\u1eb7p:<\/i><\/b> M\u1ea5t ng\u1ee7, k\u00edch th\u00edch, \u0111\u1ed9ng kinh, ban da, k\u00edch \u1ee9ng d\u1ea1 d\u00e0y, run, ph\u1ea3n \u1ee9ng d\u1ecb \u1ee9ng<\/span><\/p>\n

          3. T\u01b0\u01a1ng t\u00e1c thu\u1ed1c gi\u1eefa Rifampicin v\u00e0 Theophylin<\/b><\/h2>\n

          3.1 C\u01a1 ch\u1ebf<\/b><\/h3>\n

          C\u00f3 2 c\u01a1 ch\u1ebf t\u01b0\u01a1ng t\u00e1c thu\u1ed1c x\u1ea3y ra:<\/span><\/p>\n

            \n
          • Rifampicin s\u1ebd l\u00e0m gi\u1ea3m m\u1ee9c \u0111\u1ed9 ho\u1eb7c t\u00e1c d\u1ee5ng c\u1ee7a Theophylin b\u1eb1ng c\u00e1ch \u1ea3nh h\u01b0\u1edfng \u0111\u1ebfn chuy\u1ec3n h\u00f3a men gan\/ru\u1ed9t CYP3A4. (1)<\/span><\/li>\n
          • Rifampicin s\u1ebd l\u00e0m gi\u1ea3m m\u1ee9c \u0111\u1ed9 ho\u1eb7c t\u00e1c d\u1ee5ng c\u1ee7a Theophylin b\u1eb1ng c\u00e1ch \u1ea3nh h\u01b0\u1edfng \u0111\u1ebfn chuy\u1ec3n h\u00f3a enzym CYP1A2 \u1edf gan. (2)<\/span><\/li>\n<\/ul>\n

            3.2 T\u00e1c d\u1ee5ng ph\u1ee5 c\u00f3 th\u1ec3 x\u1ea3y ra khi s\u1eed d\u1ee5ng Rifampicin v\u00e0 Theophylin c\u00f9ng nhau<\/b><\/h3>\n
              \n
            • Suy h\u00f4 h\u1ea5p<\/span><\/li>\n
            • T\u0103ng huy\u1ebft \u00e1p<\/span><\/li>\n
            • Nh\u1ecbp tim nhanh<\/span><\/li>\n
            • Gi\u1ea3m kh\u1ea3 n\u0103ng t\u1eadp trung<\/span><\/li>\n
            • Kh\u00f3 ng\u1ee7<\/span><\/li>\n
            • Bu\u1ed3n n\u00f4n<\/span><\/li>\n
            • N\u00f4n m\u1eeda<\/span><\/li>\n
            • \u0110au \u0111\u1ea7u<\/span><\/li>\n
            • Ch\u00f3ng m\u1eb7t<\/span><\/li>\n
            • T\u0103ng \u0111\u01b0\u1eddng huy\u1ebft<\/span><\/li>\n<\/ul>\n

              3.3 Bi\u1ec7n ph\u00e1p x\u1eed l\u00fd<\/b><\/h3>\n

              Tr\u00e1nh k\u1ebft h\u1ee3p hai lo\u1ea1i thu\u1ed1c n\u00e0y ho\u1eb7c s\u1eed d\u1ee5ng thu\u1ed1c kh\u00e1c thay th\u1ebf.\u00a0<\/span><\/p>\n

              B\u1ec7nh nh\u00e2n n\u00ean \u0111\u01b0\u1ee3c theo d\u00f5i nh\u1eefng thay \u0111\u1ed5i v\u1ec1 n\u1ed3ng \u0111\u1ed9 Theophylin trong huy\u1ebft thanh ho\u1eb7c \u0111\u00e1p \u1ee9ng kh\u00f4ng \u0111\u1ea7y \u0111\u1ee7 v\u1edbi Theophylin n\u1ebfu ti\u1ec1m n\u0103ng \u0111\u01b0\u1ee3c coi l\u00e0 l\u1edbn h\u01a1n r\u1ee7i ro.<\/span><\/p>\n

              3.4 M\u1ee9c \u0111\u1ed9 t\u01b0\u01a1ng t\u00e1c thu\u1ed1c t\u1eeb nhi\u1ec1u ngu\u1ed3n kh\u00e1c nhau<\/b><\/h3>\n

              Drug: V\u1eeba ph\u1ea3i<\/span><\/p>\n

              Medscape:<\/span><\/p>\n

                \n
              • (1): Nghi\u00eam tr\u1ecdng<\/span><\/li>\n
              • (2): V\u1eeba ph\u1ea3i<\/span><\/li>\n<\/ul>\n

                WebMD:\u00a0<\/span><\/p>\n

                  \n
                • (1): Nghi\u00eam tr\u1ecdng<\/span><\/li>\n
                • (2): V\u1eeba ph\u1ea3i<\/span><\/li>\n<\/ul>\n

                  4. K\u1ebft lu\u1eadn<\/b><\/h2>\n

                  T\u01b0\u01a1ng t\u00e1c thu\u1ed1c gi\u1eefa Rifampicin v\u00e0 Theophylin c\u00f3 th\u1ec3 g\u00e2y ra c\u00e1c t\u00e1c d\u1ee5ng ph\u1ee5 nghi\u00eam tr\u1ecdng v\u00e0 \u1ea3nh h\u01b0\u1edfng \u0111\u1ebfn hi\u1ec7u qu\u1ea3 \u0111i\u1ec1u tr\u1ecb. Do \u0111\u00f3, c\u00e1c chuy\u00ean gia y t\u1ebf c\u1ea7n h\u1ebft s\u1ee9c c\u1ea9n tr\u1ecdng khi k\u00ea \u0111\u01a1n hai lo\u1ea1i thu\u1ed1c n\u00e0y c\u00f9ng m\u1ed9t l\u00fac v\u00e0 n\u00ean theo d\u00f5i ch\u1eb7t ch\u1ebd t\u00ecnh tr\u1ea1ng s\u1ee9c kh\u1ecfe c\u1ee7a b\u1ec7nh nh\u00e2n \u0111\u1ec3 tr\u00e1nh c\u00e1c t\u00e1c d\u1ee5ng kh\u00f4ng mong mu\u1ed1n. N\u1ebfu c\u1ea7n thi\u1ebft, c\u00e1c gi\u1ea3i ph\u00e1p thay th\u1ebf kh\u00e1c c\u00f3 th\u1ec3 \u0111\u01b0\u1ee3c xem x\u00e9t \u0111\u1ec3 \u0111\u1ea3m b\u1ea3o hi\u1ec7u qu\u1ea3 \u0111i\u1ec1u tr\u1ecb v\u00e0 an to\u00e0n cho b\u1ec7nh nh\u00e2n.\u00a0<\/span><\/p>\n

                  Ngu\u1ed3n: D\u01b0\u1ee3c th\u01b0 Qu\u1ed1c gia Vi\u1ec7t Nam, Medscape<\/span><\/p>\n","protected":false},"excerpt":{"rendered":"

                  Rifampicin v\u00e0 Theophylin l\u00e0 hai lo\u1ea1i thu\u1ed1c \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng r\u1ed9ng r\u00e3i trong \u0111i\u1ec1u tr\u1ecb c\u00e1c b\u1ec7nh l\u00fd kh\u00e1c nhau. Tuy nhi\u00ean, t\u01b0\u01a1ng t\u00e1c gi\u1eefa hai lo\u1ea1i thu\u1ed1c n\u00e0y c\u00f3 th\u1ec3 \u1ea3nh h\u01b0\u1edfng \u0111\u1ebfn hi\u1ec7u qu\u1ea3 \u0111i\u1ec1u tr\u1ecb v\u00e0 g\u00e2y ra c\u00e1c t\u00e1c d\u1ee5ng ph\u1ee5 nghi\u00eam tr\u1ecdng. C\u00e1c chuy\u00ean gia y t\u1ebf c\u1ea7n h\u1ebft s\u1ee9c […]<\/p>\n","protected":false},"author":53,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[12],"tags":[],"yoast_head":"\nT\u01b0\u01a1ng t\u00e1c thu\u1ed1c gi\u1eefa Rifampicin v\u00e0 Theophylin - Vinmec<\/title>\n<meta name=\"description\" content=\"Rifampicin v\u00e0 Theophylin l\u00e0 hai lo\u1ea1i thu\u1ed1c \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng r\u1ed9ng r\u00e3i trong \u0111i\u1ec1u tr\u1ecb c\u00e1c b\u1ec7nh l\u00fd kh\u00e1c nhau. 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