{"id":25921,"date":"2023-04-22T23:06:26","date_gmt":"2023-04-22T16:06:26","guid":{"rendered":"http:\/\/noithathoaphat.in\/ctv\/?p=25921"},"modified":"2023-04-22T23:06:26","modified_gmt":"2023-04-22T16:06:26","slug":"tuong-tac-thuoc-giua-carbamazepin-va-theophylin","status":"publish","type":"post","link":"http:\/\/noithathoaphat.in\/ctv\/index.php\/2023\/04\/22\/tuong-tac-thuoc-giua-carbamazepin-va-theophylin\/","title":{"rendered":"T\u01b0\u01a1ng t\u00e1c thu\u1ed1c gi\u1eefa Carbamazepin v\u00e0 Theophylin"},"content":{"rendered":"<p><b>Carbamazepin v\u00e0 Theophylin l\u00e0 hai lo\u1ea1i thu\u1ed1c \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng r\u1ed9ng r\u00e3i trong \u0111i\u1ec1u tr\u1ecb c\u00e1c b\u1ec7nh l\u00fd kh\u00e1c nhau. Tuy nhi\u00ean, t\u01b0\u01a1ng t\u00e1c gi\u1eefa hai lo\u1ea1i thu\u1ed1c n\u00e0y c\u00f3 th\u1ec3 \u1ea3nh h\u01b0\u1edfng \u0111\u1ebfn hi\u1ec7u qu\u1ea3 \u0111i\u1ec1u tr\u1ecb v\u00e0 g\u00e2y ra c\u00e1c t\u00e1c d\u1ee5ng ph\u1ee5 nghi\u00eam tr\u1ecdng. C\u00e1c chuy\u00ean gia y t\u1ebf c\u1ea7n h\u1ebft s\u1ee9c c\u1ea9n tr\u1ecdng khi k\u00ea \u0111\u01a1n hai lo\u1ea1i thu\u1ed1c n\u00e0y c\u00f9ng m\u1ed9t l\u00fac v\u00e0 n\u00ean theo d\u00f5i ch\u1eb7t ch\u1ebd t\u00ecnh tr\u1ea1ng s\u1ee9c kh\u1ecfe c\u1ee7a b\u1ec7nh nh\u00e2n \u0111\u1ec3 tr\u00e1nh c\u00e1c t\u00e1c d\u1ee5ng kh\u00f4ng mong mu\u1ed1n.<\/b><\/p>\n<h2><b>1. Th\u00f4ng tin chung v\u1ec1 thu\u1ed1c Carbamazepin<\/b><\/h2>\n<h3><b>1.1 C\u01a1 ch\u1ebf t\u00e1c d\u1ee5ng<\/b><\/h3>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">T\u00e1c d\u1ee5ng d\u01b0\u1ee3c l\u00fd c\u1ee7a Carbamazepin t\u01b0\u01a1ng t\u1ef1 nh\u01b0 t\u00e1c d\u1ee5ng c\u1ee7a c\u00e1c ch\u1ea5t ch\u1ed1ng co gi\u1eadt thu\u1ed9c nh\u00f3m d\u1eabn ch\u1ea5t Hydantoin. T\u00e1c d\u1ee5ng ch\u1ed1ng co gi\u1eadt c\u1ee7a Carbamazepin nh\u01b0 Phenytoin, ch\u1ee7 y\u1ebfu li\u00ean quan \u0111\u1ebfn vi\u1ec7c h\u1ea1n ch\u1ebf d\u1eabn truy\u1ec1n qua synap b\u1eb1ng c\u00e1ch l\u00e0m gi\u1ea3m \u0111i\u1ec7n th\u1ebf m\u00e0ng t\u1ebf b\u00e0o. Carbamazepin l\u00e0m gi\u1ea3m \u0111au d\u00e2y th\u1ea7n kinh tam thoa do l\u00e0m gi\u1ea3m d\u1eabn truy\u1ec1n qua synap trong nh\u00e2n tam thoa. Thu\u1ed1c c\u0169ng \u0111\u01b0\u1ee3c ch\u1ee9ng minh l\u00e0 c\u00f3 t\u00e1c d\u1ee5ng an th\u1ea7n, kh\u00e1ng Cholinergic, ch\u1ed1ng tr\u1ea7m c\u1ea3m, gi\u00e3n c\u01a1, ch\u1ed1ng lo\u1ea1n nh\u1ecbp tim, kh\u00e1ng b\u00e0i ni\u1ec7u v\u00e0 \u1ee9c ch\u1ebf d\u1eabn truy\u1ec1n th\u1ea7n kinh \u2013 c\u01a1. Carbamazepin ch\u1ec9 c\u00f3 t\u00e1c d\u1ee5ng gi\u1ea3m \u0111au nh\u1eb9.<\/span><\/li>\n<\/ul>\n<figure id=\"attachment_25909\" aria-describedby=\"caption-attachment-25909\" style=\"width: 300px\" class=\"wp-caption aligncenter\"><img decoding=\"async\" loading=\"lazy\" class=\"size-medium wp-image-25909\" src=\"http:\/\/noithathoaphat.in\/ctv\/wp-content\/uploads\/2023\/04\/Carbamazepin-300x261.jpg\" alt=\"Carbamazepin\" width=\"300\" height=\"261\" srcset=\"http:\/\/noithathoaphat.in\/ctv\/wp-content\/uploads\/2023\/04\/Carbamazepin-300x261.jpg 300w, http:\/\/noithathoaphat.in\/ctv\/wp-content\/uploads\/2023\/04\/Carbamazepin.jpg 340w\" sizes=\"(max-width: 300px) 100vw, 300px\" \/><figcaption id=\"caption-attachment-25909\" class=\"wp-caption-text\">Carbamazepin<\/figcaption><\/figure>\n<h3><b>1.2 Ch\u1ec9 \u0111\u1ecbnh<\/b><\/h3>\n<p><span style=\"font-weight: 400;\">B\u1ec7nh \u0111\u1ed9ng kinh:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><a href=\"https:\/\/www.vinmec.com\/vi\/tin-tuc\/thong-tin-suc-khoe\/suc-khoe-tong-quat\/tim-hieu-ve-dong-kinh-cuc-bo-van-dong\/\"><span style=\"font-weight: 400;\">\u0110\u1ed9ng kinh c\u1ee5c b\u1ed9<\/span><\/a><span style=\"font-weight: 400;\"> c\u00f3 tri\u1ec7u ch\u1ee9ng ph\u1ee9c h\u1ee3p (\u0111\u1ed9ng kinh t\u00e2m th\u1ea7n v\u1eadn \u0111\u1ed9ng, \u0111\u1ed9ng kinh th\u00f9y th\u00e1i d\u01b0\u01a1ng).\u00a0<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">\u0110\u1ed9ng kinh c\u01a1n l\u1edbn (co c\u1ee9ng \u2013 co gi\u1eadt to\u00e0n b\u1ed9).<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">C\u00e1c ki\u1ec3u \u0111\u1ed9ng kinh ph\u1ee9c h\u1ee3p g\u1ed3m c\u00e1c lo\u1ea1i tr\u00ean ho\u1eb7c c\u00e1c lo\u1ea1i \u0111\u1ed9ng kinh c\u1ee5c b\u1ed9 ho\u1eb7c to\u00e0n b\u1ed9 kh\u00e1c.<\/span><\/li>\n<\/ul>\n<p><span style=\"font-weight: 400;\">\u0110au d\u00e2y th\u1ea7n kinh tam thoa:\u00a0<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Gi\u1ea3m \u0111au trong b\u1ec7nh \u0111au d\u00e2y th\u1ea7n kinh tam thoa<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Gi\u1ea3m \u0111au d\u00e2y th\u1ea7n kinh l\u01b0\u1ee1i \u2013 h\u1ea7u.<\/span><\/li>\n<\/ul>\n<p><span style=\"font-weight: 400;\">B\u1ec7nh h\u01b0ng \u2013 tr\u1ea7m c\u1ea3m (r\u1ed1i lo\u1ea1n l\u01b0\u1ee1ng c\u1ef1c):\u00a0<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">D\u1ef1 ph\u00f2ng b\u1ec7nh h\u01b0ng \u2013 tr\u1ea7m c\u1ea3m \u1edf c\u00e1c ng\u01b0\u1eddi b\u1ec7nh kh\u00f4ng \u0111\u00e1p \u1ee9ng v\u1edbi Lithium<\/span><\/li>\n<\/ul>\n<h3><b>1.3 T\u00e1c d\u1ee5ng ph\u1ee5<\/b><\/h3>\n<p><b><i>Th\u01b0\u1eddng g\u1eb7p:<\/i><\/b><span style=\"font-weight: 400;\"> Ch\u00f3ng m\u1eb7t, gi\u1ea3m b\u1ea1ch c\u1ea7u, gi\u1ea3m ti\u1ec3u c\u1ea7u, m\u1ea5t \u0111i\u1ec1u ph\u1ed1i, m\u1ec7t m\u1ecfi, ng\u1ee7 g\u00e0, \u0111au \u0111\u1ea7u, ch\u00e1n \u0103n, bu\u1ed3n n\u00f4n, n\u00f4n, kh\u00f4 mi\u1ec7ng, k\u00edch \u1ee9ng tr\u1ef1c tr\u00e0ng n\u1ebfu d\u00f9ng \u0111\u1ea1n tr\u1ef1c tr\u00e0ng,&#8230;<\/span><\/p>\n<p><b><i>\u00cdt g\u1eb7p:<\/i><\/b><span style=\"font-weight: 400;\"> Ti\u00eau ch\u1ea3y, t\u00e1o b\u00f3n, run, m\u1ea5t th\u0103ng b\u1eb1ng, lo\u1ea1n tr\u01b0\u01a1ng l\u1ef1c c\u01a1, rung gi\u1eadt c\u01a1, run gi\u1eadt nh\u00e3n c\u1ea7u,&#8230;<\/span><\/p>\n<p><b><i>Hi\u1ebfm g\u1eb7p:<\/i><\/b><span style=\"font-weight: 400;\"> N\u00f3i kh\u00f3, r\u1ed1i lo\u1ea1n v\u1eadn nh\u00e3n, vi\u00eam th\u1ea7n kinh ngo\u1ea1i vi, vi\u00eam m\u00e0ng n\u00e3o v\u00f4 khu\u1ea9n, y\u1ebfu c\u01a1, li\u1ec7t nh\u1eb9, thay \u0111\u1ed5i v\u1ecb gi\u00e1c, vi\u00eam l\u01b0\u1ee1i, vi\u00eam mi\u1ec7ng, \u0111au b\u1ee5ng, vi\u00eam t\u1ee5y, block nh\u0129 \u2013 th\u1ea5t v\u00e0 nh\u1ecbp tim ch\u1eadm, c\u00e1c tai bi\u1ebfn huy\u1ebft kh\u1ed1i t\u1eafc m\u1ea1ch, suy tim sung huy\u1ebft, suy tu\u1ea7n ho\u00e0n, h\u1ea1 huy\u1ebft \u00e1p ho\u1eb7c t\u0103ng huy\u1ebft \u00e1p, vi\u00eam t\u1eafc t\u0129nh m\u1ea1ch v\u00e0 l\u00e0m n\u1eb7ng th\u00eam ch\u1ee9ng thi\u1ebfu m\u00e1u c\u1ee5c b\u1ed9 m\u1ea1ch v\u00e0nh, vi\u00eam t\u0129nh m\u1ea1ch huy\u1ebft kh\u1ed1i, huy\u1ebft kh\u1ed1i \u2013 ngh\u1ebdn m\u1ea1ch,&#8230;<\/span><\/p>\n<h2><b>2. Th\u00f4ng tin chung v\u1ec1 thu\u1ed1c Theophylin<\/b><\/h2>\n<h3><b>2.1 C\u01a1 ch\u1ebf t\u00e1c d\u1ee5ng<\/b><\/h3>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">C\u00e1c c\u01a1 ch\u1ebf t\u00e1c d\u1ee5ng d\u01b0\u1ee3c l\u00fd c\u1ee7a Theophylin \u0111\u01b0\u1ee3c \u0111\u1ec1 xu\u1ea5t bao g\u1ed3m (1) \u1ee9c ch\u1ebf phosphodiesterase, do \u0111\u00f3 l\u00e0m t\u0103ng AMP v\u00f2ng n\u1ed9i b\u00e0o, (2) t\u00e1c d\u1ee5ng tr\u1ef1c ti\u1ebfp tr\u00ean n\u1ed3ng \u0111\u1ed9 Calci n\u1ed9i b\u00e0o, (3) t\u00e1c d\u1ee5ng gi\u00e1n ti\u1ebfp tr\u00ean n\u1ed3ng \u0111\u1ed9 Calci n\u1ed9i b\u00e0o th\u00f4ng qua t\u0103ng ph\u00e2n c\u1ef1c m\u00e0ng t\u1ebf b\u00e0o, (4) \u0111\u1ed1i kh\u00e1ng th\u1ee5 th\u1ec3 adenosin, \u0111\u1ed1i kh\u00e1ng prostaglandin. Theophylin \u0111\u01b0\u1ee3c d\u00f9ng nh\u01b0 l\u00e0 m\u1ed9t thu\u1ed1c gi\u00e3n ph\u1ebf qu\u1ea3n trong x\u1eed tr\u00ed t\u1eafc ngh\u1ebdn \u0111\u01b0\u1eddng th\u1edf h\u1ed3i ph\u1ee5c \u0111\u01b0\u1ee3c, nh\u01b0 hen ph\u1ebf qu\u1ea3n. Nh\u00ecn chung thu\u1ed1c ch\u1ee7 v\u1eadn beta-2 nh\u01b0 Salbutamol l\u00e0 thu\u1ed1c l\u1ef1a ch\u1ecdn h\u00e0ng \u0111\u1ea7u trong gi\u00e3n ph\u1ebf qu\u1ea3n, Theophylin th\u01b0\u1eddng \u0111\u01b0\u1ee3c d\u00f9ng h\u1ed7 tr\u1ee3 c\u00f9ng thu\u1ed1c ch\u1ee7 v\u1eadn beta-2 v\u00e0 Corticosteroid \u1edf ng\u01b0\u1eddi b\u1ec7nh c\u1ea7n th\u00eam t\u00e1c d\u1ee5ng gi\u00e3n ph\u1ebf qu\u1ea3n. S\u1ef1 k\u1ebft h\u1ee3p n\u00e0y c\u00f3 th\u1ec3 l\u00e0m t\u0103ng m\u1ed9t s\u1ed1 t\u00e1c d\u1ee5ng kh\u00f4ng mong mu\u1ed1n nh\u01b0 h\u1ea1 Kali huy\u1ebft. M\u1ed9t v\u00e0i b\u1ec7nh nh\u00e2n b\u1ecb b\u1ec7nh ph\u1ed5i t\u1eafc ngh\u1ebdn m\u1ea1n t\u00ednh c\u0169ng \u0111\u00e1p \u1ee9ng t\u1ed1t v\u1edbi Theophylin.<\/span><\/li>\n<\/ul>\n<figure id=\"attachment_23905\" aria-describedby=\"caption-attachment-23905\" style=\"width: 300px\" class=\"wp-caption aligncenter\"><img decoding=\"async\" loading=\"lazy\" class=\"size-medium wp-image-23905\" src=\"http:\/\/noithathoaphat.in\/ctv\/wp-content\/uploads\/2023\/04\/Theophylin-300x210.jpg\" alt=\"Theophylin\" width=\"300\" height=\"210\" srcset=\"http:\/\/noithathoaphat.in\/ctv\/wp-content\/uploads\/2023\/04\/Theophylin-300x210.jpg 300w, http:\/\/noithathoaphat.in\/ctv\/wp-content\/uploads\/2023\/04\/Theophylin.jpg 596w\" sizes=\"(max-width: 300px) 100vw, 300px\" \/><figcaption id=\"caption-attachment-23905\" class=\"wp-caption-text\">Theophylin<\/figcaption><\/figure>\n<h3><b>2.2 Ch\u1ec9 \u0111\u1ecbnh<\/b><\/h3>\n<p><span style=\"font-weight: 400;\">\u0110i\u1ec1u tr\u1ecb tri\u1ec7u ch\u1ee9ng v\u00e0 t\u1eafc ngh\u1ebdn \u0111\u01b0\u1eddng th\u1edf c\u00f2n h\u1ed3i ph\u1ee5c do hen m\u00e3n t\u00ednh ho\u1eb7c do c\u00e1c b\u1ec7nh ph\u1ed5i m\u1ea1n t\u00ednh kh\u00e1c:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Theo H\u01b0\u1edbng d\u1eabn \u0111i\u1ec1u tr\u1ecb hen to\u00e0n c\u1ea7u (The Global initiative for Asthma Guidelines, 2009), kh\u00f4ng khuy\u1ebfn c\u00e1o d\u00f9ng Theophylin u\u1ed1ng l\u00e0m thu\u1ed1c \u0111i\u1ec1u tr\u1ecb l\u00e2u d\u00e0i b\u1ec7nh hen ph\u1ebf qu\u1ea3n \u1edf tr\u1ebb em \u2264 5 tu\u1ed5i; \u0111\u00e3 \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng c\u00f3 hi\u1ec7u qu\u1ea3 khi th\u00eam v\u00e0o (nh\u01b0ng kh\u00f4ng \u0111\u01b0\u1ee3c \u01b0a chu\u1ed9ng) cho tr\u1ebb l\u1edbn h\u01a1n ho\u1eb7c ng\u01b0\u1eddi l\u1edbn khi \u0111i\u1ec1u tr\u1ecb hen ph\u1ebf qu\u1ea3n n\u1eb7ng c\u00f9ng v\u1edbi thu\u1ed1c h\u00edt ho\u1eb7c u\u1ed1ng Glucocorticoid. Kh\u00f4ng khuy\u1ebfn c\u00e1o d\u00f9ng Theophylin \u0111i\u1ec1u tr\u1ecb hen ti\u1ebfn tri\u1ec3n (\u0111\u1ee3t hen n\u1eb7ng).<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">C\u00f3 \u00edt ch\u1ee9ng c\u1ee9 cho th\u1ea5y Theophylin (Aminophylin) ti\u00eam t\u0129nh m\u1ea1ch c\u00f3 th\u1ec3 c\u00f3 t\u00e1c d\u1ee5ng khi d\u00f9ng th\u00eam \u1edf tr\u1ebb em n\u1eb1m trong ph\u00f2ng \u0111i\u1ec1u tr\u1ecb t\u0103ng c\u01b0\u1eddng v\u00ec \u0111\u1ee3t hen n\u1eb7ng kh\u00f4ng ki\u1ec3m so\u00e1t \u0111\u01b0\u1ee3c b\u1eb1ng c\u00e1c thu\u1ed1c ch\u1ee7 v\u1eadn beta-2 h\u00edt v\u00e0 ti\u00eam t\u0129nh m\u1ea1ch, Ipratropium bromid v\u00e0 Corticosteroid ti\u00eam t\u0129nh m\u1ea1ch; tuy v\u1eady, hi\u1ec7u qu\u1ea3 n\u00e0y ch\u01b0a \u0111\u01b0\u1ee3c x\u00e1c \u0111\u1ecbnh \u1edf ng\u01b0\u1eddi l\u1edbn. \u0110i\u1ec1u tr\u1ecb n\u00e0y kh\u00f4ng \u0111\u01b0\u1ee3c khuy\u1ebfn c\u00e1o.<\/span><\/li>\n<\/ul>\n<p><span style=\"font-weight: 400;\">B\u1ec7nh ph\u1ed5i t\u1eafc ngh\u1ebdn m\u1ea1n t\u00ednh (COPD):<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Theophylin (ch\u1ebf ph\u1ea9m u\u1ed1ng t\u00e1c d\u1ee5ng k\u00e9o d\u00e0i) c\u00f3 th\u1ec3 th\u00eam ho\u1eb7c thay th\u1ebf li\u1ec7u ph\u00e1p c\u00e1c thu\u1ed1c gi\u00e3n ph\u1ebf qu\u1ea3n t\u00e1c d\u1ee5ng k\u00e9o d\u00e0i (nh\u01b0 Tiotropium, ho\u1eb7c ch\u1ea5t ch\u1ee7 v\u1eadn ch\u1ecdn l\u1ecdc beta-2 h\u00edt) \u1edf ng\u01b0\u1eddi b\u1ec7nh b\u1ecb COPD n\u1eb7ng c\u1ea7n \u0111i\u1ec1u tr\u1ecb th\u00eam v\u00ec \u0111\u00e1p \u1ee9ng kh\u00f4ng th\u1ecfa \u0111\u00e1ng ho\u1eb7c do c\u00f3 t\u00e1c d\u1ee5ng ph\u1ee5.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Vai tr\u00f2 c\u1ee7a Theophylin \u1edf ng\u01b0\u1eddi b\u1ec7nh b\u1ecb c\u00e1c \u0111\u1ee3t n\u1eb7ng l\u00ean c\u1ee7a COPD c\u00f2n tranh c\u00e3i. M\u1ed9t s\u1ed1 chuy\u00ean gia y t\u1ebf l\u00e2m s\u00e0ng cho l\u00e0 kh\u00f4ng c\u00f3 l\u1ee3i, c\u00f3 khi c\u00f2n c\u00f3 t\u00e1c d\u1ee5ng x\u1ea5u.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Li\u1ec1u cao ch\u1ebf ph\u1ea9m Theophylin gi\u1ea3i ph\u00f3ng ch\u1eadm tuy \u0111\u00e3 \u0111\u01b0\u1ee3c ch\u1ee9ng minh c\u00f3 t\u00e1c d\u1ee5ng trong \u0111i\u1ec1u tr\u1ecb b\u1ec7nh ph\u1ed5i t\u1eafc ngh\u1ebdn m\u1ea1n t\u00ednh, nh\u01b0ng kh\u00f4ng ph\u1ea3i l\u00e0 thu\u1ed1c \u0111\u01b0\u1ee3c \u01b0a d\u00f9ng v\u00ec c\u00f3 ti\u1ec1m n\u0103ng \u0111\u1ed9c t\u00ednh.<\/span><\/li>\n<\/ul>\n<h3><b>2.3 T\u00e1c d\u1ee5ng ph\u1ee5<\/b><\/h3>\n<p><b><i>Th\u01b0\u1eddng g\u1eb7p:<\/i><\/b><span style=\"font-weight: 400;\"> Nh\u1ecbp tim nhanh, t\u00ecnh tr\u1ea1ng k\u00edch \u0111\u1ed9ng, b\u1ed3n ch\u1ed3n, bu\u1ed3n n\u00f4n, n\u00f4n.<\/span><\/p>\n<p><b><i>\u00cdt g\u1eb7p:<\/i><\/b><span style=\"font-weight: 400;\"> M\u1ea5t ng\u1ee7, k\u00edch th\u00edch, \u0111\u1ed9ng kinh, ban da, k\u00edch \u1ee9ng d\u1ea1 d\u00e0y, run, ph\u1ea3n \u1ee9ng d\u1ecb \u1ee9ng<\/span><\/p>\n<h2><b>3. T\u01b0\u01a1ng t\u00e1c thu\u1ed1c gi\u1eefa Carbamazepin v\u00e0 Theophylin<\/b><\/h2>\n<h3><b>3.1 C\u01a1 ch\u1ebf<\/b><\/h3>\n<p><span style=\"font-weight: 400;\">C\u00f3 3 c\u01a1 ch\u1ebf t\u01b0\u01a1ng t\u00e1c thu\u1ed1c x\u1ea3y ra gi\u1eefa ho\u1ea1t ch\u1ea5t Carbamazepin v\u00e0 Theophylin:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Carbamazepin s\u1ebd l\u00e0m gi\u1ea3m m\u1ee9c \u0111\u1ed9 ho\u1eb7c t\u00e1c d\u1ee5ng c\u1ee7a Theophylin b\u1eb1ng c\u00e1ch \u1ea3nh h\u01b0\u1edfng \u0111\u1ebfn chuy\u1ec3n h\u00f3a enzym CYP3A4 \u1edf gan\/ru\u1ed9t. (1)<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Theophylin l\u00e0m gi\u1ea3m n\u1ed3ng \u0111\u1ed9 Carbamazepin b\u1eb1ng c\u00e1ch t\u0103ng chuy\u1ec3n h\u00f3a. (2)<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Carbamazepin s\u1ebd l\u00e0m gi\u1ea3m m\u1ee9c \u0111\u1ed9 ho\u1eb7c t\u00e1c d\u1ee5ng c\u1ee7a Theophylin b\u1eb1ng c\u00e1ch \u1ea3nh h\u01b0\u1edfng \u0111\u1ebfn chuy\u1ec3n h\u00f3a enzym CYP1A2 \u1edf gan. (3)<\/span><\/li>\n<\/ul>\n<h3><b>3.2 T\u00e1c d\u1ee5ng ph\u1ee5 c\u00f3 th\u1ec3 x\u1ea3y ra khi s\u1eed d\u1ee5ng Carbamazepin v\u00e0 Theophylin c\u00f9ng nhau<\/b><\/h3>\n<p><span style=\"font-weight: 400;\">B\u1ec7nh nh\u00e2n c\u00f3 th\u1ec3\u00a0 g\u1eb7p c\u00e1c v\u1ea5n \u0111\u1ec1 v\u1ec1 h\u00f4 h\u1ea5p ng\u00e0y c\u00e0ng tr\u1ea7m tr\u1ecdng<\/span><\/p>\n<h3><b>3.3 Bi\u1ec7n ph\u00e1p x\u1eed l\u00fd<\/b><\/h3>\n<p><span style=\"font-weight: 400;\">Tr\u00e1nh k\u1ebft h\u1ee3p 2 lo\u1ea1i thu\u1ed1c n\u00e0y ho\u1eb7c s\u1eed d\u1ee5ng thu\u1ed1c thay th\u1ebf.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Trong tr\u01b0\u1eddng h\u1ee3p n\u1ebfu l\u1ee3i \u00edch \u0111\u01b0\u1ee3c coi l\u00e0 l\u1edbn h\u01a1n r\u1ee7i ro b\u1ec7nh nh\u00e2n n\u00ean \u0111\u01b0\u1ee3c theo d\u00f5i ch\u1eb7t ch\u1ebd c\u00e1c b\u1eb1ng ch\u1ee9ng l\u00e2m s\u00e0ng v\u00e0 x\u00e9t nghi\u1ec7m v\u1ec1 t\u00e1c d\u1ee5ng thay \u0111\u1ed5i \u0111\u1ed1i v\u1edbi c\u1ea3 hai thu\u1ed1c.<\/span><\/p>\n<h3><b>3.4 M\u1ee9c \u0111\u1ed9 t\u01b0\u01a1ng t\u00e1c thu\u1ed1c t\u1eeb nhi\u1ec1u ngu\u1ed3n kh\u00e1c nhau<\/b><\/h3>\n<p><span style=\"font-weight: 400;\">Drugs bank: V\u1eeba ph\u1ea3i<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Medscape:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">(1), (2): Nghi\u00eam tr\u1ecdng<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">(3): V\u1eeba ph\u1ea3i<\/span><\/li>\n<\/ul>\n<p><span style=\"font-weight: 400;\">WebMD:\u00a0<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">(1), (2): Nghi\u00eam tr\u1ecdng<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">(3): V\u1eeba ph\u1ea3i<\/span><\/li>\n<\/ul>\n<h2><b>4. K\u1ebft lu\u1eadn<\/b><\/h2>\n<p><span style=\"font-weight: 400;\">T\u01b0\u01a1ng t\u00e1c thu\u1ed1c gi\u1eefa Carbamazepin v\u00e0 Theophylin c\u00f3 th\u1ec3 g\u00e2y ra c\u00e1c t\u00e1c d\u1ee5ng ph\u1ee5 nghi\u00eam tr\u1ecdng v\u00e0 \u1ea3nh h\u01b0\u1edfng \u0111\u1ebfn hi\u1ec7u qu\u1ea3 \u0111i\u1ec1u tr\u1ecb. Do \u0111\u00f3, c\u00e1c chuy\u00ean gia y t\u1ebf c\u1ea7n h\u1ebft s\u1ee9c c\u1ea9n tr\u1ecdng khi k\u00ea \u0111\u01a1n hai lo\u1ea1i thu\u1ed1c n\u00e0y c\u00f9ng m\u1ed9t l\u00fac v\u00e0 n\u00ean theo d\u00f5i ch\u1eb7t ch\u1ebd t\u00ecnh tr\u1ea1ng s\u1ee9c kh\u1ecfe c\u1ee7a b\u1ec7nh nh\u00e2n \u0111\u1ec3 tr\u00e1nh c\u00e1c t\u00e1c d\u1ee5ng kh\u00f4ng mong mu\u1ed1n. N\u1ebfu c\u1ea7n thi\u1ebft, c\u00e1c gi\u1ea3i ph\u00e1p thay th\u1ebf kh\u00e1c c\u00f3 th\u1ec3 \u0111\u01b0\u1ee3c xem x\u00e9t \u0111\u1ec3 \u0111\u1ea3m b\u1ea3o hi\u1ec7u qu\u1ea3 \u0111i\u1ec1u tr\u1ecb v\u00e0 an to\u00e0n cho b\u1ec7nh nh\u00e2n.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Ngu\u1ed3n: D\u01b0\u1ee3c th\u01b0 Qu\u1ed1c gia Vi\u1ec7t Nam, Medscape.com<\/span><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Carbamazepin v\u00e0 Theophylin l\u00e0 hai lo\u1ea1i thu\u1ed1c \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng r\u1ed9ng r\u00e3i trong \u0111i\u1ec1u tr\u1ecb c\u00e1c b\u1ec7nh l\u00fd kh\u00e1c nhau. Tuy nhi\u00ean, t\u01b0\u01a1ng t\u00e1c gi\u1eefa hai lo\u1ea1i thu\u1ed1c n\u00e0y c\u00f3 th\u1ec3 \u1ea3nh h\u01b0\u1edfng \u0111\u1ebfn hi\u1ec7u qu\u1ea3 \u0111i\u1ec1u tr\u1ecb v\u00e0 g\u00e2y ra c\u00e1c t\u00e1c d\u1ee5ng ph\u1ee5 nghi\u00eam tr\u1ecdng. C\u00e1c chuy\u00ean gia y t\u1ebf c\u1ea7n h\u1ebft s\u1ee9c [&hellip;]<\/p>\n","protected":false},"author":53,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[12],"tags":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v20.4 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>T\u01b0\u01a1ng t\u00e1c thu\u1ed1c gi\u1eefa Carbamazepin v\u00e0 Theophylin - Vinmec<\/title>\n<meta name=\"description\" content=\"Carbamazepin v\u00e0 Theophylin l\u00e0 hai lo\u1ea1i thu\u1ed1c \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng r\u1ed9ng r\u00e3i trong \u0111i\u1ec1u tr\u1ecb c\u00e1c b\u1ec7nh l\u00fd kh\u00e1c nhau. 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