{"id":24975,"date":"2023-04-21T10:32:14","date_gmt":"2023-04-21T03:32:14","guid":{"rendered":"http:\/\/noithathoaphat.in\/ctv\/?p=24975"},"modified":"2023-04-21T11:30:34","modified_gmt":"2023-04-21T04:30:34","slug":"zavegepant-thuoc-xit-mui-hieu-qua-cho-chung-dau-nua-dau-cap","status":"publish","type":"post","link":"http:\/\/noithathoaphat.in\/ctv\/index.php\/2023\/04\/21\/zavegepant-thuoc-xit-mui-hieu-qua-cho-chung-dau-nua-dau-cap\/","title":{"rendered":"Zavegepant: thu\u1ed1c x\u1ecbt m\u0169i hi\u1ec7u qu\u1ea3 cho ch\u1ee9ng \u0111au n\u1eeda \u0111\u1ea7u c\u1ea5p"},"content":{"rendered":"

Zavegepant l\u00e0 m\u1ed9t lo\u1ea1i thu\u1ed1c x\u1ecbt m\u0169i m\u1edbi \u0111\u01b0\u1ee3c ph\u00e1t tri\u1ec3n \u0111\u1ec3 gi\u1ea3m \u0111au n\u1eeda \u0111\u1ea7u c\u1ea5p t\u00ednh. \u0110\u00e2y l\u00e0 m\u1ed9t trong nh\u1eefng lo\u1ea1i thu\u1ed1c c\u00f3 hi\u1ec7u qu\u1ea3 cao v\u00e0 \u0111\u01b0\u1ee3c ch\u1ee9ng minh trong c\u00e1c nghi\u00ean c\u1ee9u l\u00e2m s\u00e0ng. Zavegepant ho\u1ea1t \u0111\u1ed9ng b\u1eb1ng c\u00e1ch \u1ee9c ch\u1ebf m\u1ed9t protein c\u00f3 t\u00ean l\u00e0 calcitonin gene-related peptide (CGRP), m\u1ed9t ch\u1ea5t \u0111\u01b0\u1ee3c cho l\u00e0 c\u00f3 li\u00ean quan \u0111\u1ebfn vi\u1ec7c g\u00e2y \u0111au n\u1eeda \u0111\u1ea7u. V\u1edbi c\u00f4ng d\u1ee5ng gi\u1ea3m \u0111au hi\u1ec7u qu\u1ea3 v\u00e0 \u0111\u1ed9 an to\u00e0n cao, Zavegepant \u0111ang \u0111\u01b0\u1ee3c xem l\u00e0 m\u1ed9t l\u1ef1a ch\u1ecdn ti\u1ec1m n\u0103ng trong \u0111i\u1ec1u tr\u1ecb ch\u1ee9ng \u0111au n\u1eeda \u0111\u1ea7u c\u1ea5p t\u00ednh.<\/strong><\/p>\n

1.T\u00ecm hi\u1ec3u v\u1ec1 ch\u1ee9ng \u0111au n\u1eeda \u0111\u1ea7u c\u1ea5p t\u00ednh\u00a0<\/strong><\/h2>\n

1.1 Gi\u1edbi thi\u1ec7u\u00a0<\/span><\/h3>\n

\u0110\u1ec3 c\u1ea3m nh\u1eadn th\u1ebf gi\u1edbi xung quanh, c\u00e1c s\u1ee3i th\u1ea7n kinh truy\u1ec1n t\u00edn hi\u1ec7u \u0111i\u1ec7n \u0111i v\u00e0 \u0111\u1ebfn t\u1eeb n\u00e3o v\u00e0 t\u1ee7y s\u1ed1ng, c\u00e1c c\u01a1 quan c\u1ea3m gi\u00e1c trong to\u00e0n b\u1ed9 c\u01a1 th\u1ec3 thu th\u1eadp th\u00f4ng tin \u0111\u01b0\u1ee3c t\u00edn hi\u1ec7u truy\u1ec1n \u0111\u1ebfn n\u00e3o th\u00f4ng qua c\u00e1c t\u1ebf b\u00e0o th\u1ea7n kinh. M\u1ed7i t\u00edn hi\u1ec7u th\u1ea7n kinh \u0111\u01b0\u1ee3c truy\u1ec1n t\u1eeb t\u1eadn c\u00f9ng m\u1ed9t t\u1ebf b\u00e0o th\u1ea7n kinh \u0111\u1ebfn nh\u1eefng t\u1ebf b\u00e0o kh\u00e1c qua c\u00e1c k\u00eanh ion, c\u00e1c ion \u0111i qua c\u00e1c k\u00eanh xuy\u00ean qua d\u00e2y th\u1ea7n kinh gi\u00fap t\u1ed5ng h\u1ee3p d\u00f2ng \u0111i\u1ec7n t\u1ea1i v\u1ecb tr\u00ed t\u1eadn c\u00f9ng d\u00e2y th\u1ea7n kinh. C\u00e1c t\u00edn hi\u1ec7u th\u1ea7n kinh t\u1eeb n\u00e3o b\u1ed9 h\u00ecnh th\u00e0nh xung th\u1ea7n kinh ch\u00ednh l\u00e0 \u0111i\u1ec7n th\u1ebf ho\u1ea1t \u0111\u1ed9ng lan truy\u1ec1n d\u1ecdc theo s\u1ee3i tr\u1ee5c c\u1ee7a n\u01a1ron, c\u00e1c n\u01a1ron th\u1ea7n kinh sinh ra c\u00e1c enzyme gi\u00fap t\u1ed5ng h\u1ee3p ch\u1ea5t d\u1eabn truy\u1ec1n th\u1ea7n kinh l\u00e0 nh\u1eefng ch\u1ea5t h\u00f3a h\u1ecdc c\u00f3 vai tr\u00f2 d\u1eabn truy\u1ec1n xung \u0111\u1ed9ng qua c\u00e1c khe synap gi\u1eefa hai t\u1ebf b\u00e0o th\u1ea7n kinh li\u1ec1n k\u1ec1 nhau, ho\u1eb7c gi\u1eefa t\u1ebf b\u00e0o th\u1ea7n kinh v\u00e0 t\u1ebf b\u00e0o \u0111\u00edch m\u00e0 xung th\u1ea7n kinh h\u01b0\u1edbng t\u1edbi t\u1ebf b\u00e0o \u0111\u00edch (c\u01a1, tuy\u1ebfn)<\/span><\/p>\n

Ch\u1ee9ng \u0111au n\u1eeda \u0111\u1ea7u<\/a> l\u00e0 m\u1ed9t r\u1ed1i lo\u1ea1n di truy\u1ec1n, t\u1eebng \u0111\u1ee3t li\u00ean quan \u0111\u1ebfn s\u1ef1 nh\u1ea1y c\u1ea3m c\u1ee7a c\u00e1c gi\u00e1c quan v\u00e0 \u1ea3nh h\u01b0\u1edfng s\u1ef1 thay \u0111\u1ed5i qu\u00e1 tr\u00ecnh x\u1eed l\u00fd th\u00f4ng tin c\u1ee7a c\u00e1c n\u01a1ron th\u1ea7n kinh trung \u01b0\u01a1ng (k\u00edch ho\u1ea1t c\u00e1c nh\u00e2n c\u1ee7a th\u00e2n n\u00e3o, t\u0103ng kh\u1ea3 n\u0103ng k\u00edch th\u00edch c\u1ee7a v\u1ecf n\u00e3o v\u00e0 \u1ee9c ch\u1ebf v\u1ecf n\u00e3o lan t\u1ecfa) v\u00e0 s\u1ef1 tham gia c\u1ee7a h\u1ec7 th\u1ed1ng th\u1ea7n kinh m\u1ea1ch m\u00e1u (k\u00edch ho\u1ea1t s\u1ef1 gi\u1ea3i ph\u00f3ng neuropeptide, g\u00e2y vi\u00eam \u0111au trong c\u00e1c m\u1ea1ch n\u1ed9i s\u1ecd v\u00e0 m\u00e0ng c\u1ee9ng). Ch\u1ee9ng \u0111au n\u1eeda \u0111\u1ea7u \u1ea3nh h\u01b0\u1edfng \u0111\u1ebfn kho\u1ea3ng 12% d\u00e2n s\u1ed1. \u01af\u1edbc t\u00ednh to\u00e0n c\u1ea7u cao h\u01a1n. Ch\u1ee9ng \u0111au n\u1eeda \u0111\u1ea7u m\u00e3n t\u00ednh (CM) \u1ea3nh h\u01b0\u1edfng \u0111\u1ebfn 1% \u0111\u1ebfn 2% d\u00e2n s\u1ed1 to\u00e0n c\u1ea7u. Kho\u1ea3ng 2,5% nh\u1eefng ng\u01b0\u1eddi b\u1ecb ch\u1ee9ng \u0111au n\u1eeda \u0111\u1ea7u t\u1eebng c\u01a1n ti\u1ebfn tri\u1ec3n th\u00e0nh CM.<\/span><\/p>\n

\"\u0110au
\u0110au n\u1eeda \u0111\u1ea7u<\/figcaption><\/figure>\n

1.2 Tri\u1ec7u ch\u1ee9ng c\u1ee7a b\u1ec7nh \u0111au n\u1eeda \u0111\u1ea7u\u00a0<\/span><\/h3>\n

Ti\u1ec1n tri\u1ec7u (b\u00e1o hi\u1ec7u c\u00e1c c\u01a1n \u0111au) bao g\u1ed3m: thay \u0111\u1ed5i kh\u00ed s\u1eafc, m\u1ea5t c\u1ea3m gi\u00e1c ngon mi\u1ec7ng, bu\u1ed3n n\u00f4n, ho\u1eb7c ph\u1ed1i h\u1ee3p c\u1ea3 hai<\/span><\/p>\n

Aura xu\u1ea5t hi\u1ec7n tr\u01b0\u1edbc c\u01a1n \u0111au: tri\u1ec7u ch\u1ee9ng th\u1ecb gi\u00e1c (r\u1ed1i lo\u1ea1n th\u1ecb gi\u00e1c), di c\u1ea3m v\u00e0 t\u00ea b\u00ec, r\u1ed1i lo\u1ea1n ng\u00f4n ng\u1eef, r\u1ed1i lo\u1ea1n ch\u1ee9c n\u0103ng th\u00e2n n\u00e3o tho\u00e1ng qua (ch\u1ee9ng m\u1ea5t ng\u1ee7, l\u00fa l\u1eabn)<\/span><\/p>\n

\u0110au \u0111\u1ea7u: t\u1eeb trung b\u00ecnh \u0111\u1ebfn n\u1eb7ng, k\u00e9o d\u00e0i t\u1eeb 4 gi\u1edd \u0111\u1ebfn v\u00e0i ng\u00e0y, th\u01b0\u1eddng \u0111au m\u1ed9t b\u00ean ho\u1eb7c hai b\u00ean<\/span><\/p>\n

Tri\u1ec7u ch\u1ee9ng bu\u1ed3n n\u00f4n, s\u1ee3 \u00e1nh s\u00e1ng, s\u1ee3 ti\u1ebfng \u0111\u1ed9ng, s\u1ee3 m\u00f9i kh\u00f3 ch\u1ecbu<\/span><\/p>\n

1.3 Nguy\u00ean nh\u00e2n\u00a0<\/span><\/h3>\n

C\u00f3 r\u1ea5t nhi\u1ec1u nguy\u00ean nh\u00e2n kh\u00e1c nhau g\u00e2y n\u00ean ch\u1ee9ng \u0111au n\u1eeda \u0111\u1ea7u bao g\u1ed3m:\u00a0<\/span><\/p>\n

    \n
  • S\u1ef1 thay \u0111\u1ed5i Hormone: sau m\u00e3n kinh, chu k\u1ef3 kinh nguy\u1ec7t, thay \u0111\u1ed5i l\u01b0\u1ee3ng Estrogen\u00a0<\/span><\/li>\n
  • S\u1ef1 thay \u0111\u1ed5i c\u1ea3m x\u00fac: stress, c\u00fa shock, tr\u1ea7m c\u1ea3m, lo l\u1eafng<\/span><\/li>\n
  • S\u1ef1 thay \u0111\u1ed5i v\u1ec1 th\u1ec3 ch\u1ea5t: m\u1ec7t m\u1ecfi, h\u1ea1 \u0111\u01b0\u1eddng huy\u1ebft, c\u00f4ng vi\u1ec7c l\u00e0m th\u00eam, ch\u1ea5t l\u01b0\u1ee3ng ng\u1ee7 th\u1ea5p, c\u00e1c v\u1ea5n \u0111\u1ec1 v\u1ec1 c\u1ed9t s\u1ed1ng<\/span><\/li>\n
  • T\u00e1c nh\u00e2n ch\u1ebf \u0111\u1ed9 \u0103n u\u1ed1ng: b\u1ecf b\u1eefa, r\u01b0\u1ee3u bia, s\u1ea3n ph\u1ea9m ch\u1ee9a Caffeine, th\u1ee9c \u0103n ch\u1ee9a Tyramine<\/span><\/li>\n
  • T\u00e1c nh\u00e2n m\u00f4i tr\u01b0\u1eddng: ti\u1ebfng \u1ed3n, kh\u00f4ng kh\u00ed \u00f4 nhi\u1ec5m, h\u00fat thu\u1ed1c, ti\u1ebfp x\u00fac v\u1edbi \u00e1nh s\u00e1ng c\u01b0\u1eddng \u0111\u1ed9 cao qu\u00e1 l\u00e2u, t\u1eadp trung v\u00e0o m\u00e0n h\u00ecnh, thay \u0111\u1ed5i kh\u00ed h\u1eadu\u00a0<\/span><\/li>\n
  • \u1ea2nh h\u01b0\u1edfng c\u1ee7a c\u00e1c lo\u1ea1i thu\u1ed1c: thu\u1ed1c ng\u1ee7, thu\u1ed1c tr\u00e1nh thai, li\u1ec7u ph\u00e1p thay th\u1ebf Hormone<\/span><\/li>\n<\/ul>\n

    1.4 Ch\u1ea9n \u0111o\u00e1n\u00a0<\/span><\/h3>\n

    N\u1ebfu c\u00f3 tri\u1ec7u ch\u1ee9ng l\u00e2m s\u00e0ng, l\u00e0m th\u00eam c\u00e1c x\u00e9t nghi\u1ec7m c\u1eadn l\u00e2m s\u00e0ng \u0111\u1ec3 \u0111\u01b0a ra ch\u1ea9n \u0111o\u00e1n ch\u00ednh x\u00e1c g\u1ed3m: x\u00e9t nghi\u1ec7m m\u00e1u, ch\u1ee5p MRI ho\u1eb7c CT, \u0111i\u1ec7n n\u00e3o \u0111\u1ed3 (EEG)<\/span><\/p>\n

    1.5 \u0110i\u1ec1u tr\u1ecb\u00a0<\/span><\/h3>\n

    Hi\u1ec7n nay v\u1eabn ch\u01b0a c\u00f3 ph\u01b0\u01a1ng ph\u00e1p \u0111i\u1ec1u tr\u1ecb d\u1ee9t \u0111i\u1ec3m cho ch\u1ee9ng \u0111au n\u1eeda \u0111\u1ea7u. Nh\u01b0ng nhi\u1ec1u thu\u1ed1c c\u00f3 th\u1ec3 \u0111\u01b0\u1ee3c ch\u1ee9ng minh l\u00e0m gi\u1ea3m b\u1edbt ho\u1eb7c th\u1eadm ch\u1ec9 ng\u0103n ng\u1eeba ch\u1ee9ng \u0111au n\u1eeda \u0111\u1ea7u\u00a0<\/span><\/p>\n

    C\u00e1c thu\u1ed1c gi\u1ea3m \u0111au: th\u00e0nh ph\u1ea7n ch\u00ednh trong thu\u1ed1c g\u1ed3m Acetaminophen, Aspirin, Caffeine, Ibuprofen. Kh\u00f4ng n\u00ean k\u00ea Aspirin cho b\u1ea5t k\u1ef3 \u0111\u1ed1i t\u01b0\u1ee3ng n\u00e0o d\u01b0\u1edbi 19 tu\u1ed5i v\u00ec c\u00f3 nguy c\u01a1 cao m\u1eafc h\u1ed9i ch\u1ee9ng Reye. Th\u1eadn tr\u1ecdng khi k\u00ea \u0111\u01a1n thu\u1ed1c gi\u1ea3m \u0111au v\u00ec c\u00f3 th\u1ec3 s\u1ebd l\u00e0m t\u0103ng c\u01b0\u1eddng c\u01a1n nh\u1ee9c \u0111\u1ea7u<\/span><\/p>\n

    C\u00e1c thu\u1ed1c ch\u1ed1ng bu\u1ed3n n\u00f4n: l\u00e0m gi\u1ea3m tri\u1ec7u ch\u1ee9ng bu\u1ed3n n\u00f4n c\u1ee7a b\u1ec7nh\u00a0<\/span><\/p>\n

    Nh\u00f3m thu\u1ed1c Triptan: c\u00e1c thu\u1ed1c trong nh\u00f3m n\u00e0y gi\u00fap c\u00e2n b\u1eb1ng ch\u1ea5t h\u00f3a h\u1ecdc trong n\u00e3o (Almotriptan, Eletriptan, Rizatriptan, Sumatriptan, Zolmitriptan,…)<\/span><\/p>\n

    Nh\u00f3m thu\u1ed1c Ergotamine: c\u00e1c thu\u1ed1c \u1ee9c ch\u1ebf c\u00e1c t\u00e1c nh\u00e2n h\u00f3a h\u1ecdc trong n\u00e3o ng\u0103n ch\u1eb7n h\u00ecnh th\u00e0nh c\u00e1c c\u01a1n \u0111au \u0111\u1ea7u m\u1edbi (Cafergot, Ergomar, Migergot)<\/span><\/p>\n

    Nh\u00f3m thu\u1ed1c Lasmiditan nh\u01b0 Reyvow l\u00e0m gi\u1ea3m c\u00e1c c\u01a1n \u0111au, c\u01a1n bu\u1ed3n n\u00f4n, gi\u00fap lo\u1ea1i b\u1ecf tri\u1ec7u ch\u1ee9ng nh\u1ea1y c\u1ea3m v\u1edbi \u00e1nh s\u00e1ng ho\u1eb7c ti\u1ebfng \u1ed3n\u00a0<\/span><\/p>\n

    Nh\u00f3m thu\u1ed1c kh\u00e1ng th\u1ee5 th\u1ec3 CGPR g\u1ed3m c\u00e1c thu\u1ed1c Rimegepant, Ubrogepant n\u1ebfu c\u00e1c ph\u01b0\u01a1ng ph\u00e1p tr\u1ecb li\u1ec7u kh\u00e1c kh\u00f4ng kh\u1ea3 thi\u00a0<\/span><\/p>\n

    2.T\u1ed5ng quan thu\u1ed1c m\u1edbi Zavegepant\u00a0<\/strong><\/h2>\n

    \u0110\u1ea7u th\u00e1ng 3 n\u0103m 2023, C\u1ee5c qu\u1ea3n l\u00fd Th\u1ef1c ph\u1ea9m v\u00e0 D\u01b0\u1ee3c ph\u1ea9m Hoa K\u1ef3 (FDA) \u0111\u00e3 c\u00f4ng nh\u1eadn v\u00e0 ph\u00ea duy\u1ec7t Zavegepant, m\u1ed9t lo\u1ea1i thu\u1ed1c x\u1ecbt m\u0169i \u0111\u1ed1i kh\u00e1ng th\u1ee5 th\u1ec3 peptide li\u00ean quan \u0111\u1ebfn Calcitonin (CGRP) \u0111ang \u0111\u01b0\u1ee3c nghi\u00ean c\u1ee9u trong \u0111i\u1ec1u tr\u1ecb ch\u1ee9ng \u0111au n\u1eeda \u0111\u1ea7u c\u1ea5p t\u00ednh. Zavegepant \u0111\u01b0\u1ee3c b\u00e1n tr\u00ean th\u1ecb tr\u01b0\u1eddng v\u1edbi t\u00ean Zavzpret v\u00e0 li\u1ec7u ph\u00e1p n\u00e0y tr\u1edf th\u00e0nh thu\u1ed1c x\u1ecbt m\u0169i CGRP \u0111\u1ea7u ti\u00ean v\u00e0 duy nh\u1ea5t \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng cho b\u1ec7nh nh\u00e2n m\u1eafc ch\u1ee9ng \u0111au n\u1eeda \u0111\u1ea7u. Trong hai nghi\u00ean c\u1ee9u th\u1eed nghi\u1ec7m m\u00f9 \u0111\u00f4i khi so s\u00e1nh v\u1edbi gi\u1ea3 d\u01b0\u1ee3c, thu\u1ed1c \u0111\u00e3 ch\u1ee9ng minh s\u1ef1 kh\u00e1c bi\u1ec7t c\u00f3 \u00fd ngh\u0129a th\u1ed1ng k\u00ea v\u01b0\u1ee3t tr\u1ed9i h\u01a1n gi\u1ea3 d\u01b0\u1ee3c v\u1ec1 c\u00f4ng d\u1ee5ng h\u1ebft \u0111au v\u00e0 kh\u00f4ng g\u00e2y tri\u1ec7u ch\u1ee9ng kh\u00f3 ch\u1ecbu. Vi\u1ec7c FDA ch\u1ea5p thu\u1eadn Zavzpret \u0111\u00e1nh d\u1ea5u b\u01b0\u1edbc \u0111\u1ed9t ph\u00e1 quan tr\u1ecdng \u0111\u1ed1i v\u1edbi nh\u1eefng b\u1ec7nh nh\u00e2n m\u1eafc ch\u1ee9ng \u0111au n\u1eeda \u0111\u1ea7u khi c\u1ea3i thi\u1ec7n c\u01a1n \u0111au v\u00e0 l\u1ef1a ch\u1ecdn t\u1ed1i \u01b0u thay th\u1ebf cho c\u00e1c thu\u1ed1c d\u00f9ng \u0111\u01b0\u1eddng u\u1ed1ng kh\u00e1c.\u00a0<\/span><\/p>\n

    \"Zavzpret
    Zavzpret (Zavegepant)<\/figcaption><\/figure>\n

    2.1 Nh\u00f3m d\u01b0\u1ee3c l\u00fd v\u00e0 ch\u1ec9 \u0111\u1ecbnh s\u1eed d\u1ee5ng c\u1ee7a Zavegepant\u00a0<\/span><\/h3>\n

    Zavegepant thu\u1ed9c nh\u00f3m thu\u1ed1c \u0111\u1ed1i kh\u00e1ng th\u1ee5 th\u1ec3 CGRP \u0111\u01b0\u1ee3c ch\u1ec9 \u0111\u1ecbnh \u0111i\u1ec1u tr\u1ecb ch\u1ee9ng \u0111au n\u1eeda \u0111\u1ea7u c\u1ea5p t\u00ednh c\u00f3 ho\u1eb7c kh\u00f4ng c\u00f3 tri\u1ec7u ch\u1ee9ng Aura. C\u00e1c thu\u1ed1c thu\u1ed9c nh\u00f3m \u0111\u1ed1i kh\u00e1ng th\u1ee5 th\u1ec3 CGRP \u0111\u01b0\u1ee3c bi\u1ebft \u0111\u1ebfn trong t\u00ean g\u1ecdi c\u00f3 \u0111u\u00f4i \u201cgepants\u201d nh\u01b0 Rimegepant hay Ubrogepant. Trong \u0111\u00f3, Zavegepant thu\u1ed9c th\u1ebf h\u1ec7 th\u1ee9 3 v\u1edbi k\u00edch th\u01b0\u1edbc nh\u1ecf v\u00e0 tan t\u1ed1t trong n\u01b0\u1edbc<\/span><\/p>\n

    2.2 C\u01a1 ch\u1ebf ho\u1ea1t \u0111\u1ed9ng\u00a0<\/span><\/h3>\n

    Zavegepant ho\u1ea1t \u0111\u1ed9ng nh\u01b0 ch\u1ea5t \u0111\u1ed1i kh\u00e1ng th\u1ee5 th\u1ec3 peptide li\u00ean quan \u0111\u1ebfn Calcitonin (CGRP). CGRP l\u00e0 m\u1ed9t neuropeptide g\u1ed3m 37 acid amin c\u00f3 hai d\u1ea1ng (\u03b1 v\u00e0 \u03b2). CGRP \u0111\u01b0\u1ee3c gi\u1ea3i ph\u00f3ng t\u1eeb c\u00e1c d\u00e2y th\u1ea7n c\u1ea3m gi\u00e1c, ho\u1ea1t \u0111\u1ed9ng nh\u01b0 m\u1ed9t ch\u1ea5t gi\u00e3n m\u1ea1ch m\u1ea1nh v\u00e0 \u0111\u00f3ng vai tr\u00f2 quan tr\u1ecdng \u0111\u1ec3 ch\u1eefa l\u00e0nh v\u1ebft th\u01b0\u01a1ng v\u00e0 sinh l\u00fd tim m\u1ea1ch. Do \u0111\u1eb7c t\u00ednh gi\u00e3n m\u1ea1ch, CGRP gi\u1ea3i ph\u00f3ng c\u00e1c ch\u1ea5t trung gian g\u00e2y vi\u00eam t\u1eeb t\u1ebf b\u00e0o mast v\u00e0 truy\u1ec1n th\u00f4ng tin \u0111au \u0111\u1ebfn h\u1ec7 th\u1ea7n kinh trung \u01b0\u01a1ng. Ch\u1ea5t \u0111\u1ed1i kh\u00e1ng th\u1ee5 th\u1ec3 CGRP \u0111\u00e3 \u0111\u01b0\u1ee3c ch\u1ee9ng minh ho\u1ea1t \u0111\u1ed9ng t\u01b0\u01a1ng t\u1ef1 v\u1edbi CGRP do \u0111\u00f3 g\u1eafn v\u00e0o th\u1ee5 th\u1ec3 thay th\u1ebf v\u1ecb tr\u00ed c\u1ee7a CGRP. Trong ch\u1ee9ng \u0111au n\u1eeda \u0111\u1ea7u c\u1ea5p t\u00ednh, vi\u1ec7c gi\u1ea3i ph\u00f3ng CGRP l\u00e0m t\u0103ng gi\u00e3n m\u1ea1ch v\u00e0 \u0111i\u1ec1u ch\u1ec9nh t\u00ednh d\u1ec5 b\u1ecb k\u00edch th\u00edch c\u1ee7a t\u1ebf b\u00e0o th\u1ea7n kinh, t\u1ea1o \u0111i\u1ec1u ki\u1ec7n cho ph\u1ea3n \u1ee9ng \u0111au trong c\u00e1c c\u1ea5u tr\u00fac d\u1eabn truy\u1ec1n c\u01a1n \u0111au n\u1eeda \u0111\u1ea7u, ch\u1eb3ng h\u1ea1n nh\u01b0 h\u1ec7 th\u1ed1ng sinh ba n\u00ean \u1ee9c ch\u1ebf c\u01a1 ch\u1ebf gi\u00e3n m\u1ea1ch v\u00e0 l\u00e0m gi\u1ea3m nh\u1ea1y c\u1ea3m c\u00e1c m\u1ea1ch th\u1ea7n kinh<\/span><\/p>\n

    2.3 D\u01b0\u1ee3c \u0111\u1ed9ng h\u1ecdc\u00a0<\/span><\/h3>\n

    H\u1ea5p thu: Sau khi d\u00f9ng m\u1ed9t li\u1ec1u Zavegepant (10mg) nh\u1ecf v\u00e0o m\u0169i, n\u1ed3ng \u0111\u1ed9 \u0111\u1ec9nh \u0111\u1ea1t \u0111\u01b0\u1ee3c trong huy\u1ebft t\u01b0\u01a1ng sau 30 ph\u00fat s\u1eed d\u1ee5ng. Sinh kh\u1ea3 d\u1ee5ng tuy\u1ec7t \u0111\u1ed1i c\u1ee7a thu\u1ed1c x\u1ecbt m\u0169i l\u00e0 kho\u1ea3ng 5%. So v\u1edbi ng\u01b0\u1eddi b\u00ecnh th\u01b0\u1eddng, b\u1ec7nh nh\u00e2n suy gan c\u00f3 Cmax v\u00e0 AUC l\u1ea7n l\u01b0\u1ee3t l\u00e0 16% v\u00e0 1,9 l\u1ea7n.\u00a0<\/span><\/p>\n

    Ph\u00e2n b\u1ed1: Zavegepant d\u00f9ng trong m\u0169i c\u00f3 th\u1ec3 t\u00edch ph\u00e2n b\u1ed1 bi\u1ec3u ki\u1ebfn (Vd) \u200b\u200btrung b\u00ecnh kho\u1ea3ng 1774L.Zavegepant c\u00f3 kh\u1ea3 n\u0103ng g\u1eafn k\u1ebft v\u1edbi protein huy\u1ebft t\u01b0\u01a1ng kho\u1ea3ng 90%<\/span><\/p>\n

    Chuy\u1ec3n h\u00f3a: Zavegepant ch\u1ee7 y\u1ebfu \u0111\u01b0\u1ee3c chuy\u1ec3n h\u00f3a b\u1edfi CYP3A4 v\u00e0 m\u1ed9t ph\u1ea7n b\u1edfi enzyme CYP2D6.\u00a0<\/span><\/p>\n

    Th\u1ea3i tr\u1eeb: Zavegepant \u0111\u01b0\u1ee3c b\u00e0i ti\u1ebft ch\u1ee7 y\u1ebfu qua \u0111\u01b0\u1eddng m\u1eadt\/ph\u00e2n v\u00e0 m\u1ed9t ph\u1ea7n nh\u1ecf qua n\u01b0\u1edbc ti\u1ec3u. Sau khi d\u00f9ng li\u1ec1u 10 mg, Zavegepant d\u00f9ng trong m\u0169i c\u00f3 th\u1eddi gian b\u00e1n h\u1ee7y (T1\/2) hi\u1ec7u qu\u1ea3 l\u00e0 6,55 gi\u1edd. \u0110\u1ed9 thanh th\u1ea3i bi\u1ec3u ki\u1ebfn trung b\u00ecnh l\u00e0 266L\/h<\/span><\/p>\n

    2.4 T\u00e1c d\u1ee5ng ph\u1ee5\u00a0<\/span><\/h3>\n

    Tuy hi\u1ec7u qu\u1ea3 \u0111i\u1ec1u tr\u1ecb \u0111\u00e3 \u0111\u01b0\u1ee3c ch\u1ee9ng minh nh\u01b0ng khi s\u1eed d\u1ee5ng Zavegepant c\u0169ng g\u00e2y ra m\u1ed9t s\u1ed1 t\u00e1c d\u1ee5ng ph\u1ee5 ngo\u00e0i \u00fd mu\u1ed1n nghi\u00eam tr\u1ecdng nh\u01b0: kh\u00f3 th\u1edf, r\u1ed1i lo\u1ea1n v\u1ecb gi\u00e1c, d\u1ecb \u1ee9ng n\u1ed5i m\u1ea9n, ph\u00e1t ban, n\u1ed5i s\u01b0ng tr\u00ean m\u1eb7t, m\u00f4i, l\u01b0\u1ee1i, n\u00f4n, bu\u1ed3n n\u00f4n\u00a0<\/span><\/p>\n

    2.5 Li\u1ec1u s\u1eed d\u1ee5ng v\u00e0 ch\u1ed1ng ch\u1ec9 \u0111\u1ecbnh\u00a0<\/span><\/h3>\n

    Li\u1ec1u khuy\u1ebfn c\u00e1o s\u1eed d\u1ee5ng Zavzpret \u0111\u01b0\u1ee3c ch\u1ea5p thu\u1eadn l\u00e0 10mg x\u1ecbt 1 l\u1ea7n\u00a0<\/span><\/p>\n

    Li\u1ec1u t\u1ed1i \u0111a c\u00f3 th\u1ec3 \u0111\u01b0\u1ee3c khuy\u1ebfn c\u00e1o trong 24 gi\u1edd l\u00e0 1 l\u1ea7n x\u1ecbt 10mg<\/span><\/p>\n

    Zavegepant ch\u1ed1ng ch\u1ec9 \u0111\u1ecbnh s\u1eed d\u1ee5ng \u1edf c\u00e1c \u0111\u1ed1i t\u01b0\u1ee3ng ng\u01b0\u1eddi b\u1ec7nh c\u00f3 ti\u1ec1n s\u1eed x\u1ea3y ra c\u00e1c ph\u1ea3n \u1ee9ng nh\u1ea1y c\u1ea3m qu\u00e1 m\u1ee9c v\u1edbi b\u1ea5t k\u1ef3 th\u00e0nh ph\u1ea7n n\u00e0o\u00a0<\/span><\/p>\n

    2.6 T\u01b0\u01a1ng t\u00e1c thu\u1ed1c<\/span><\/h3>\n

    Zavzpret c\u00f3 th\u1ec3 t\u01b0\u01a1ng t\u00e1c v\u1edbi c\u00e1c lo\u1ea1i thu\u1ed1c kh\u00e1c nh\u01b0: (1) thu\u1ed1c \u1ee9c ch\u1ebf ch\u1ea5t v\u1eadn chuy\u1ec3n OATP1B3 ho\u1eb7c NTCP, (2) thu\u1ed1c g\u00e2y ra ch\u1ea5t v\u1eadn chuy\u1ec3n OATP1B3 ho\u1eb7c NTCP v\u00e0 (3) <\/span>thu\u1ed1c th\u00f4ng m\u0169i.<\/span><\/p>\n

    3.K\u1ebft lu\u1eadn\u00a0<\/strong><\/h2>\n

    Zavegepant c\u00f3 th\u1ec3 c\u00f3 vai tr\u00f2 t\u1ed1i \u01b0u trong \u0111i\u1ec1u tr\u1ecb c\u1ea5p t\u00ednh ch\u1ee9ng \u0111au n\u1eeda \u0111\u1ea7u nh\u01b0 m\u1ed9t ph\u01b0\u01a1ng ph\u00e1p thay th\u1ebf hi\u1ec7u qu\u1ea3 cho c\u00e1c thu\u1ed1c u\u1ed1ng v\u00e0 thu\u1ed1c ti\u00eam, \u0111\u1eb7c bi\u1ec7t ph\u00e1t huy t\u1ed1i \u0111a hi\u1ec7u qu\u1ea3 \u0111\u1ed1i v\u1edbi nh\u1eefng b\u1ec7nh nh\u00e2n mong mu\u1ed1n t\u00e1c d\u1ee5ng nhanh c\u1ee7a thu\u1ed1c.<\/span><\/p>\n

     <\/p>\n","protected":false},"excerpt":{"rendered":"

    Zavegepant l\u00e0 m\u1ed9t lo\u1ea1i thu\u1ed1c x\u1ecbt m\u0169i m\u1edbi \u0111\u01b0\u1ee3c ph\u00e1t tri\u1ec3n \u0111\u1ec3 gi\u1ea3m \u0111au n\u1eeda \u0111\u1ea7u c\u1ea5p t\u00ednh. \u0110\u00e2y l\u00e0 m\u1ed9t trong nh\u1eefng lo\u1ea1i thu\u1ed1c c\u00f3 hi\u1ec7u qu\u1ea3 cao v\u00e0 \u0111\u01b0\u1ee3c ch\u1ee9ng minh trong c\u00e1c nghi\u00ean c\u1ee9u l\u00e2m s\u00e0ng. 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