{"id":24686,"date":"2023-04-21T10:49:00","date_gmt":"2023-04-21T03:49:00","guid":{"rendered":"http:\/\/noithathoaphat.in\/ctv\/?p=24686"},"modified":"2023-04-22T06:41:56","modified_gmt":"2023-04-21T23:41:56","slug":"so-sanh-hieu-qua-teriparatide-va-risedronate-trong-loang-xuong","status":"publish","type":"post","link":"http:\/\/noithathoaphat.in\/ctv\/index.php\/2023\/04\/21\/so-sanh-hieu-qua-teriparatide-va-risedronate-trong-loang-xuong\/","title":{"rendered":"So s\u00e1nh Teriparatide v\u00e0 Risedronate trong \u0111i\u1ec1u tr\u1ecb lo\u00e3ng x\u01b0\u01a1ng"},"content":{"rendered":"

Teriparatide v\u00e0 Risedronate l\u00e0 hai lo\u1ea1i thu\u1ed1c \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng \u0111\u1ec3 \u0111i\u1ec1u tr\u1ecb lo\u00e3ng x\u01b0\u01a1ng. Teriparatide l\u00e0 m\u1ed9t lo\u1ea1i thu\u1ed1c k\u00edch th\u00edch t\u1ea1o ra x\u01b0\u01a1ng m\u1edbi, trong khi Risedronate l\u00e0 m\u1ed9t bisphosphonate, c\u00f3 t\u00e1c d\u1ee5ng ng\u0103n ch\u1eb7n s\u1ef1 ph\u00e2n h\u1ee7y x\u01b0\u01a1ng. Hi\u1ec7u qu\u1ea3 c\u1ee7a c\u1ea3 hai lo\u1ea1i thu\u1ed1c \u0111\u00e3 \u0111\u01b0\u1ee3c ch\u1ee9ng minh trong nhi\u1ec1u nghi\u00ean c\u1ee9u l\u00e2m s\u00e0ng, tuy nhi\u00ean, s\u1ef1 kh\u00e1c bi\u1ec7t trong c\u01a1 ch\u1ebf t\u00e1c \u0111\u1ed9ng v\u00e0 c\u00e1ch s\u1eed d\u1ee5ng c\u1ee7a ch\u00fang c\u00f3 th\u1ec3 d\u1eabn \u0111\u1ebfn hi\u1ec7u qu\u1ea3 kh\u00e1c nhau \u1edf m\u1ed7i b\u1ec7nh nh\u00e2n. Do \u0111\u00f3, vi\u1ec7c so s\u00e1nh hi\u1ec7u qu\u1ea3 c\u1ee7a Teriparatide v\u00e0 Risedronate trong \u0111i\u1ec1u tr\u1ecb lo\u00e3ng x\u01b0\u01a1ng l\u00e0 r\u1ea5t quan tr\u1ecdng \u0111\u1ec3 gi\u00fap b\u1ec7nh nh\u00e2n v\u00e0 chuy\u00ean gia y t\u1ebf l\u1ef1a ch\u1ecdn ph\u01b0\u01a1ng ph\u00e1p \u0111i\u1ec1u tr\u1ecb t\u1ed1t nh\u1ea5t cho t\u1eebng tr\u01b0\u1eddng h\u1ee3p c\u1ee5 th\u1ec3.<\/strong><\/p>\n

1.Gi\u1edbi thi\u1ec7u v\u1ec1 b\u1ec7nh lo\u00e3ng x\u01b0\u01a1ng\u00a0<\/strong><\/h2>\n

Lo\u00e3ng x\u01b0\u01a1ng l\u00e0 m\u1ed9t c\u0103n b\u1ec7nh li\u00ean quan \u0111\u1ebfn m\u1eadt \u0111\u1ed9 v\u00e0 c\u1ea5u tr\u00fac c\u1ee7a x\u01b0\u01a1ng th\u01b0\u1eddng g\u1eb7p \u1edf nh\u1eefng \u0111\u1ed1i t\u01b0\u1ee3ng b\u1ec7nh nh\u00e2n l\u1edbn tu\u1ed5i. Lo\u00e3ng x\u01b0\u01a1ng l\u00e0m gi\u1ea3m m\u1eadt \u0111\u1ed9 ch\u1ea5t kho\u00e1ng trong x\u01b0\u01a1ng v\u00e0 gi\u1ea3m c\u1ea5u tr\u00fac x\u01b0\u01a1ng l\u00e0m cho x\u01b0\u01a1ng y\u1ebfu d\u1eabn \u0111\u1ebfn d\u1ec5 g\u00e3y x\u01b0\u01a1ng khi g\u1eb7p nh\u1eefng ch\u1ea5n th\u01b0\u01a1ng nh\u1ecf ho\u1eb7c ch\u1ea5n th\u01b0\u01a1ng kh\u00f4ng r\u00f5 nguy\u00ean nh\u00e2n \u1edf c\u1ed9t s\u1ed1ng l\u01b0ng, th\u1eaft l\u01b0ng, c\u1ed5 tay v\u00e0 kh\u1edbp h\u00e1ng<\/span><\/p>\n

\"Lo\u00e3ng
Lo\u00e3ng x\u01b0\u01a1ng<\/figcaption><\/figure>\n

Sinh l\u00fd b\u1ec7nh lo\u00e3ng x\u01b0\u01a1ng: b\u00ecnh th\u01b0\u1eddng c\u00f3 s\u1ef1 c\u00e2n b\u1eb1ng gi\u1eefa qu\u00e1 tr\u00ecnh t\u1ea1o v\u00e0 h\u1ee7y x\u01b0\u01a1ng. C\u1ee5 th\u1ec3, c\u00e1c t\u1ebf b\u00e0o t\u1ea1o x\u01b0\u01a1ng (c\u00e1c t\u1ebf b\u00e0o t\u1ea1o n\u00ean ch\u1ea5t n\u1ec1n c\u1ee7a x\u01b0\u01a1ng v\u00e0 sau \u0111\u00f3 kho\u00e1ng h\u00f3a x\u01b0\u01a1ng) v\u00e0 t\u1ebf b\u00e0o h\u1ee7y x\u01b0\u01a1ng (t\u1ebf b\u00e0o ti\u00eau x\u01b0\u01a1ng) \u0111\u01b0\u1ee3c \u0111i\u1ec1u khi\u1ec3n b\u1edfi hormone tuy\u1ebfn c\u1eadn gi\u00e1p (PTH), calcitonin, estrogen, vitamin D, c\u00e1c cytokine kh\u00e1c nhau, v\u00e0 c\u00e1c y\u1ebfu t\u1ed1 t\u1ea1i ch\u1ed7 kh\u00e1c nh\u01b0 prostaglandin. Kh\u1ed1i l\u01b0\u1ee3ng x\u01b0\u01a1ng \u0111\u1ec9nh \u1edf nam gi\u1edbi v\u00e0 n\u1eef gi\u1edbi \u0111\u1ea1t \u0111\u01b0\u1ee3c \u1edf \u0111\u1ed9 tu\u1ed5i 30. Nam gi\u1edbi c\u00f3 kh\u1ed1i l\u01b0\u1ee3ng x\u01b0\u01a1ng cao h\u01a1n ph\u1ee5 n\u1eef. Sau khi \u0111\u1ea1t \u0111\u01b0\u1ee3c kh\u1ed1i l\u01b0\u1ee3ng x\u01b0\u01a1ng \u0111\u1ec9nh, m\u1eadt \u0111\u1ed9 x\u01b0\u01a1ng \u0111\u01b0\u1ee3c duy tr\u00ec trong kho\u1ea3ng 10 n\u0103m, trong th\u1eddi gian \u0111\u00f3 s\u1ef1 t\u1ea1o x\u01b0\u01a1ng g\u1ea7n b\u1eb1ng s\u1ef1 h\u1ee7y x\u01b0\u01a1ng. Sau \u0111\u00f3, qu\u00e1 tr\u00ecnh h\u1ee7y x\u01b0\u01a1ng x\u01b0\u01a1ng x\u1ea3y ra v\u1edbi t\u1ed1c \u0111\u1ed9 t\u0103ng kho\u1ea3ng 0,3 \u0111\u1ebfn 0,5% m\u1ed7i n\u0103m<\/span><\/p>\n

\"Sinh
Sinh l\u00fd b\u1ec7nh lo\u00e3ng x\u01b0\u01a1ng<\/figcaption><\/figure>\n

Lo\u00e3ng x\u01b0\u01a1ng l\u00e0 m\u1ed9t c\u0103n b\u1ec7nh to\u00e0n c\u1ea7u li\u00ean quan \u0111\u1ebfn vi\u1ec7c gi\u1ea3m s\u1ee9c m\u1ea1nh v\u00e0 ch\u1ea5t l\u01b0\u1ee3ng x\u01b0\u01a1ng v\u00e0 t\u0103ng nguy c\u01a1 g\u00e3y x\u01b0\u01a1ng. Kho\u1ea3ng 20% \u200b\u200bph\u1ee5 n\u1eef \u1edf B\u1eafc M\u1ef9 s\u1ebd b\u1ecb g\u00e3y x\u01b0\u01a1ng h\u00f4ng trong \u0111\u1eddi. \u0110\u1ed1i v\u1edbi nh\u1eefng b\u1ec7nh nh\u00e2n tr\u00ean 55 tu\u1ed5i, t\u1ef7 l\u1ec7 t\u1eed vong trong v\u00f2ng 1 n\u0103m l\u00ean t\u1edbi 39% n\u1ebfu h\u1ecd b\u1ecb g\u00e3y x\u01b0\u01a1ng h\u00f4ng; trong khi \u0111\u00f3, \u0111\u1ed1i v\u1edbi nh\u1eefng ng\u01b0\u1eddi s\u1ed1ng s\u00f3t, t\u00ecnh tr\u1ea1ng \u1ed1m y\u1ebfu s\u1ebd l\u00e0m gi\u1ea3m tu\u1ed5i th\u1ecd, gi\u1ea3m ch\u1ee9c n\u0103ng th\u1ec3 ch\u1ea5t v\u00e0 suy gi\u1ea3m ch\u1ea5t l\u01b0\u1ee3ng cu\u1ed9c s\u1ed1ng<\/span><\/p>\n

2.Th\u00f4ng tin thu\u1ed1c v\u1ec1 Teriparatide<\/strong><\/h2>\n

Teriparatide<\/a> l\u00e0 m\u1ed9t ph\u1ea7n c\u1ee7a hormone tuy\u1ebfn c\u1eadn gi\u00e1p (PTH), l\u00e0 m\u1ed9t t\u00e1c nh\u00e2n \u0111\u1ed3ng h\u00f3a m\u1ea1nh \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng trong \u0111i\u1ec1u tr\u1ecb lo\u00e3ng x\u01b0\u01a1ng. PTH n\u1ed9i sinh l\u00e0 ch\u1ea5t \u0111i\u1ec1u h\u00f2a ch\u00ednh c\u1ee7a chuy\u1ec3n h\u00f3a Canxi v\u00e0 Phosphate trong x\u01b0\u01a1ng<\/span><\/p>\n

\"Teriparatide\"
Teriparatide<\/figcaption><\/figure>\n

2.1 Ch\u1ec9 \u0111\u1ecbnh\u00a0<\/span><\/h3>\n

Teriparatide \u0111\u01b0\u1ee3c FDA ch\u1ea5p thu\u1eadn cho c\u00e1c ch\u1ec9 \u0111\u1ecbnh sau: (1) \u0110i\u1ec1u tr\u1ecb lo\u00e3ng x\u01b0\u01a1ng \u1edf ph\u1ee5 n\u1eef m\u00e3n kinh c\u00f3 nguy c\u01a1 g\u00e3y x\u01b0\u01a1ng cao, (2) T\u0103ng kh\u1ed1i l\u01b0\u1ee3ng x\u01b0\u01a1ng \u1edf nam gi\u1edbi b\u1ecb lo\u00e3ng x\u01b0\u01a1ng nguy\u00ean ph\u00e1t ho\u1eb7c thi\u1ec3u n\u0103ng sinh d\u1ee5c c\u00f3 nguy c\u01a1 g\u00e3y x\u01b0\u01a1ng cao, (3) \u0110i\u1ec1u tr\u1ecb cho nam gi\u1edbi v\u00e0 ph\u1ee5 n\u1eef b\u1ecb lo\u00e3ng x\u01b0\u01a1ng do Glucocorticoid to\u00e0n th\u00e2n c\u00f3 nguy c\u01a1 g\u00e3y x\u01b0\u01a1ng cao<\/span><\/p>\n

2.2 C\u01a1 ch\u1ebf ho\u1ea1t \u0111\u1ed9ng\u00a0<\/span><\/h3>\n

Vi\u1ec7c ti\u1ebfp x\u00fac li\u00ean t\u1ee5c v\u1edbi PTH li\u1ec1u th\u1ea5p (Teriparatide s\u1eed d\u1ee5ng h\u00e0ng ng\u00e0y) gi\u00fap h\u00ecnh th\u00e0nh t\u1ebf b\u00e0o x\u01b0\u01a1ng nhi\u1ec1u h\u01a1n qu\u00e1 tr\u00ecnh ti\u00eau x\u01b0\u01a1ng. Teriparatide l\u00e0 ch\u1ea5t t\u01b0\u01a1ng t\u1ef1 v\u1edbi PTH li\u00ean k\u1ebft v\u1edbi th\u1ee5 th\u1ec3 PTH lo\u1ea1i 1 (PTH lo\u1ea1i 1R) qua v\u1ecb tr\u00ed t\u1eadn c\u00f9ng nguy\u00ean t\u1ed1 N. PTH lo\u1ea1i 1R l\u00e0 c\u00e1c th\u1ee5 th\u1ec3 k\u1ebft h\u1ee3p v\u1edbi G-protein (GPCR) tr\u00ean b\u1ec1 m\u1eb7t c\u1ee7a c\u00e1c t\u1ebf b\u00e0o kh\u00e1c nhau trong \u0111\u00f3 c\u00f3 nguy\u00ean b\u00e0o x\u01b0\u01a1ng, t\u1ebf b\u00e0o x\u01b0\u01a1ng. Sau khi li\u00ean k\u1ebft, PTH ho\u1ea1t h\u00f3a protein kinase A (PKA) v\u00e0 C (PKC) qua trung gian Gs c\u1ee7a Adenylate cyclase v\u00e0 Gq. T\u00e1c d\u1ee5ng \u0111\u1ed3ng h\u00f3a c\u1ee7a ACTH l\u00e0m t\u0103ng ho\u1ea1t \u0111\u1ed9ng c\u1ee7a Runx2 \u2013 y\u1ebfu t\u1ed1 phi\u00ean m\u00e3 c\u1ea7n thi\u1ebft cho nguy\u00ean b\u00e0o x\u01b0\u01a1ng, gi\u1ea3m qu\u00e1 tr\u00ecnh t\u1ed5ng h\u1ee3p ch\u1ea5t x\u01a1 c\u1ee9ng \u0111\u1ed1i kh\u00e1ng Wnt t\u1eeb \u0111\u00f3 t\u00e1c \u0111\u1ed9ng l\u00ean con \u0111\u01b0\u1eddng truy\u1ec1n t\u00edn hi\u1ec7u Wnt\/\u03b2-catenin l\u00e0 ch\u1ea5t \u0111i\u1ec1u ch\u1ec9nh quan tr\u1ecdng c\u1ee7a qu\u00e1 tr\u00ecnh t\u1ea1o x\u01b0\u01a1ng. Teriparatide c\u00f3 t\u00e1c d\u1ee5ng t\u01b0\u01a1ng t\u1ef1 nh\u01b0 PTH n\u1ed9i sinh \u0111i\u1ec1u h\u00f2a c\u00e2n b\u1eb1ng n\u1ed9i m\u00f4i Canxi v\u00e0 Phosphate b\u1eb1ng c\u00e1ch l\u00e0m t\u0103ng Canxi huy\u1ebft thanh v\u00e0 gi\u1ea3m Phosphate huy\u1ebft thanh. PTH k\u00edch th\u00edch t\u00e1i h\u1ea5p thu Canxi \u1edf \u1ed1ng l\u01b0\u1ee3n xa \u1edf th\u1eadn, \u1ee9c ch\u1ebf t\u00e1i h\u1ea5p thu Phosphate \u1edf \u1ed1ng l\u01b0\u1ee3n g\u1ea7n v\u00e0 k\u00edch ho\u1ea1t enzyme 1-alpha-hydroxylase \u1edf \u1ed1ng l\u01b0\u1ee3n g\u1ea7n, men n\u00e0y sau \u0111\u00f3 chuy\u1ec3n 25-hydroxyvitamin D \u0111\u00e3 \u0111\u01b0\u1ee3c l\u1ecdc th\u00e0nh 1,25-dihydroxy vitamin D.\u00a0<\/span><\/p>\n

2.3 T\u00e1c d\u1ee5ng ph\u1ee5\u00a0<\/span><\/h3>\n

Teriparatide l\u00e0 m\u1ed9t lo\u1ea1i thu\u1ed1c dung n\u1ea1p t\u1ed1t. C\u00e1c t\u00e1c d\u1ee5ng ph\u1ee5 ng\u1eafn h\u1ea1n \u0111\u01b0\u1ee3c b\u1ec7nh nh\u00e2n b\u00e1o c\u00e1o bao g\u1ed3m bu\u1ed3n n\u00f4n, nh\u1ee9c \u0111\u1ea7u, ch\u00f3ng m\u1eb7t v\u00e0 h\u1ea1 huy\u1ebft \u00e1p th\u1ebf \u0111\u1ee9ng. Thay \u0111\u1ed5i chuy\u1ec3n h\u00f3a Canxi l\u00e0 ph\u1ed5 bi\u1ebfn, v\u1edbi t\u0103ng Canxi m\u00e1u v\u00e0 Canxi ni\u1ec7u l\u00e0 hai t\u00e1c d\u1ee5ng ph\u1ee5 th\u01b0\u1eddng g\u1eb7p nh\u1ea5t. T\u00e1c d\u1ee5ng ph\u1ee5 \u0111\u00e1ng lo ng\u1ea1i nh\u1ea5t l\u00e0 nguy c\u01a1 g\u00e2y ung th\u01b0 x\u01b0\u01a1ng<\/span><\/p>\n

2.4 Ch\u1ed1ng ch\u1ec9 \u0111\u1ecbnh\u00a0<\/span><\/h3>\n

Teriparatide ch\u1ed1ng ch\u1ec9 \u0111\u1ecbnh \u1edf nh\u1eefng b\u1ec7nh nh\u00e2n: qu\u00e1 m\u1eabn, t\u0103ng Canxi m\u00e1u, t\u0103ng Canxi ni\u1ec7u ho\u1eb7c s\u1ecfi th\u1eadn, b\u1ec7nh Paget x\u01b0\u01a1ng, ti\u1ec1n s\u1eed b\u1ec7nh \u00e1c t\u00ednh x\u01b0\u01a1ng nguy\u00ean ph\u00e1t ho\u1eb7c th\u1ee9 ph\u00e1t, ti\u1ec1n s\u1eed b\u1ee9c x\u1ea1 ion h\u00f3a li\u00ean quan \u0111\u1ebfn x\u01b0\u01a1ng, b\u1ec7nh nhi v\u00e0 tr\u1ebb nh\u1ecf c\u00f3 \u0111\u1ea7u x\u01b0\u01a1ng h\u1edf<\/span><\/p>\n

3.Th\u00f4ng tin thu\u1ed1c v\u1ec1 Risedronate<\/strong><\/h2>\n

Risedronate l\u00e0 lo\u1ea1i thu\u1ed1c thu\u1ed9c nh\u00f3m Bisphosphate\u00a0<\/span><\/p>\n

\"Risedronate\"
Risedronate<\/figcaption><\/figure>\n

3.1 Ch\u1ec9 \u0111\u1ecbnh\u00a0<\/span><\/h3>\n

Risedronate<\/a> \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng \u0111\u1ec3 \u0111\u1ec3 \u0111i\u1ec1u tr\u1ecb ch\u1ee9ng lo\u00e3ng x\u01b0\u01a1ng c\u00f3 th\u1ec3 do m\u00e3n kinh ho\u1eb7c s\u1eed d\u1ee5ng Steroid, \u0111\u1ed1i t\u01b0\u1ee3ng c\u00f3 nguy c\u01a1 cao b\u1ecb g\u00e3y x\u01b0\u01a1ng do lo\u00e3ng x\u01b0\u01a1ng, \u0111i\u1ec1u tr\u1ecb b\u1ec7nh Paget x\u01b0\u01a1ng<\/span><\/p>\n

3.2 C\u01a1 ch\u1ebf ho\u1ea1t \u0111\u1ed9ng\u00a0<\/span><\/h3>\n

Risedronate c\u00f3 \u00e1i l\u1ef1c m\u1ea1nh m\u1ebd \u0111\u1ed1i v\u1edbi c\u00e1c tinh th\u1ec3 Hydroxyapatite (HA) trong m\u1eadt \u0111\u1ed9 ch\u1ea5t kho\u00e1ng c\u1ee7a x\u01b0\u01a1ng cho t\u00e1c \u0111\u1ed9ng nh\u01b0 t\u00e1c nh\u00e2n gi\u1ea3m qu\u00e1 tr\u00ecnh ti\u00eau x\u01b0\u01a1ng. \u1ede c\u1ea5p \u0111\u1ed9 t\u1ebf b\u00e0o, Risedronate c\u00f3 t\u00e1c d\u1ee5ng \u1ee9c ch\u1ebf c\u00e1c h\u1ee7y c\u1ed1t b\u00e0o m\u1eb7c d\u00f9 c\u00e1c h\u1ee7y c\u1ed1t b\u00e0o n\u00e0y v\u1eabn d\u00ednh v\u00e0o b\u1ec1 m\u1eb7t x\u01b0\u01a1ng nh\u01b0ng b\u1ecb gi\u1ea3m ho\u1ea1t \u0111\u1ed9ng h\u1ee7y x\u01b0\u01a1ng. Ngo\u00e0i ra, t\u00e1c d\u1ee5ng ch\u1ed1ng h\u1ee7y x\u01b0\u01a1ng c\u1ee7a Risedronate \u0111\u01b0\u1ee3c ch\u1ee9ng minh th\u00f4ng qua kh\u1ea3 n\u0103ng \u1ee9c ch\u1ebf enzyme Farnesyl pyrophosphate synthase (FPPS), khi \u0111\u00f3 n\u1ed3ng \u0111\u1ed9 Farnesyl pyrophosphate (FPP) b\u1ecb gi\u1ea3m d\u1eabn \u0111\u1ebfn suy gi\u1ea3m qu\u00e1 tr\u00ecnh Prenyl h\u00f3a c\u00e1c protein t\u00edn hi\u1ec7u GTPase nh\u01b0 Ras, Rho, Rac c\u1ea7n thi\u1ebft cho c\u00e1c qu\u00e1 tr\u00ecnh c\u1ee7a t\u1ebf b\u00e0o h\u1ee7y x\u01b0\u01a1ng nh\u01b0 t\u00e1i h\u1ea5p thu x\u01b0\u01a1ng, di chuy\u1ec3n t\u1ebf b\u00e0o, s\u1eafp x\u1ebfp l\u1ea1i t\u1ebf b\u00e0o v\u00e0 qu\u00e1 tr\u00ecnh ch\u1ebft theo ch\u01b0\u01a1ng tr\u00ecnh<\/span><\/p>\n

3.3 T\u00e1c d\u1ee5ng ph\u1ee5\u00a0<\/span><\/h3>\n

Nh\u1eefng t\u00e1c d\u1ee5ng ph\u1ee5 ph\u1ed5 bi\u1ebfn n\u00e0y c\u1ee7a Risedronate x\u1ea3y ra \u1edf h\u01a1n 1 tr\u00ean 100 ng\u01b0\u1eddi: t\u00e1o b\u00f3n, ti\u00eau ch\u1ea3y, kh\u00f3 ti\u00eau \u0111\u1ea7y b\u1ee5ng, \u0111au d\u1ea1 d\u00e0y, nh\u1ee9c \u0111\u1ea7u, \u0111au c\u01a1, x\u01b0\u01a1ng kh\u1edbp nh\u1eb9. C\u00e1c t\u00e1c d\u1ee5ng ph\u1ee5 nghi\u00eam tr\u1ecdng h\u01a1n: \u1ee3 n\u00f3ng, \u0111au tai, ph\u00e2n \u0111en ho\u1eb7c \u0111\u1ecf, \u0111au kh\u1edbp c\u01a1 x\u01b0\u01a1ng d\u1eef d\u1ed9i, s\u01b0ng ho\u1eb7c \u0111au h\u00e0m, s\u1ed1c ph\u1ea3n v\u1ec7<\/span><\/p>\n

3.4 Ch\u1ed1ng ch\u1ec9 \u0111\u1ecbnh\u00a0<\/span><\/h3>\n

Risedronate kh\u00f4ng ph\u00f9 h\u1ee3p cho c\u00e1c \u0111\u1ed1i t\u01b0\u1ee3ng sau: g\u1eb7p v\u1ea5n \u0111\u1ec1 v\u1ec1 th\u1eadn, ung th\u01b0 ho\u1eb7c \u0111ang h\u00f3a, x\u1ea1 tr\u1ecb, d\u1ecb \u1ee9ng, ph\u1ee5 n\u1eef c\u00f3 thai ho\u1eb7c cho con b\u00fa, v\u1ea5n \u0111\u1ec1 r\u0103ng mi\u1ec7ng<\/span><\/p>\n

4.So s\u00e1nh gi\u1eefa 2 thu\u1ed1c Teriparatide v\u00e0 Risedronate\u00a0<\/strong><\/h2>\n

Nghi\u00ean c\u1ee9u ph\u00e2n t\u00edch t\u1ed5ng h\u1ee3p c\u1ee7a nh\u00f3m t\u00e1c gi\u1ea3 Chengzhi Yang khi so s\u00e1nh hi\u1ec7u qu\u1ea3 v\u00e0 an to\u00e0n c\u1ee7a Teriparatide so v\u1edbi Risedronate trong \u0111i\u1ec1u tr\u1ecb lo\u00e3ng x\u01b0\u01a1ng \u0111\u00e3 cung c\u1ea5p b\u1eb1ng ch\u1ee9ng \u1edf m\u1ee9c \u0111\u1ed9 t\u01b0\u01a1ng \u0111\u1ed1i cao cho th\u1ea5y t\u1ec9 l\u1ec7 g\u00e3y x\u01b0\u01a1ng, g\u00e3y \u0111\u1ed1t s\u1ed1ng v\u00e0 g\u00e3y x\u01b0\u01a1ng ngo\u00e0i \u0111\u1ed1t s\u1ed1ng \u1edf nh\u00f3m d\u00f9ng Teriparatide th\u1ea5p h\u01a1n \u0111\u00e1ng k\u1ec3 so v\u1edbi nh\u00f3m d\u00f9ng Risedronate. Ngo\u00e0i ra, trong nghi\u00ean c\u1ee9u \u0111\u01b0\u1ee3c b\u00e1o c\u00e1o b\u1edfi Gluer CC v\u00e0 c\u1ed9ng s\u1ef1 ch\u1ee9ng minh m\u1eadt \u0111\u1ed9 kho\u00e1ng x\u01b0\u01a1ng c\u1ed9t s\u1ed1ng th\u1eaft l\u01b0ng t\u0103ng nhi\u1ec1u h\u01a1n \u1edf b\u1ec7nh nh\u00e2n \u0111i\u1ec1u tr\u1ecb b\u1eb1ng Teriparatide so v\u1edbi b\u1ec7nh nh\u00e2n \u0111i\u1ec1u tr\u1ecb b\u1eb1ng Risedronate sau 18 th\u00e1ng \u0111i\u1ec1u tr\u1ecb. Tuy v\u1eady m\u1ee9c \u0111\u1ed9 an to\u00e0n khi s\u1eed d\u1ee5ng 2 lo\u1ea1i thu\u1ed1c kh\u00f4ng c\u00f3 s\u1ef1 kh\u00e1c bi\u1ec7t \u0111\u00e1ng k\u1ec3 v\u1edbi t\u1ec9 l\u1ec7 x\u1ea3y ra t\u00e1c d\u1ee5ng ph\u1ee5 t\u01b0\u01a1ng \u0111\u01b0\u01a1ng nhau. Malouf-Sierra, J c\u00f9ng c\u1ed9ng s\u1ef1 sau khi ho\u00e0n th\u00e0nh nghi\u00ean c\u1ee9u \u0111\u01b0a ra k\u1ebft qu\u1ea3 cho th\u1ea5y nh\u1eefng b\u1ec7nh nh\u00e2n \u0111\u01b0\u1ee3c \u0111i\u1ec1u tr\u1ecb b\u1eb1ng Teriparatide c\u00f3 s\u1ef1 gia t\u0103ng \u0111\u00e1ng k\u1ec3 t\u00ecnh tr\u1ea1ng t\u0103ng axit uric m\u00e1u sau 6 tu\u1ea7n v\u00e0 t\u0103ng Canxi huy\u1ebft sau 26 tu\u1ea7n so v\u1edbi nh\u1eefng b\u1ec7nh nh\u00e2n \u0111i\u1ec1u tr\u1ecb b\u1eb1ng Risedronate. T\u00f3m l\u1ea1i, c\u00f3 nhi\u1ec1u nghi\u00ean c\u1ee9u \u0111\u01b0\u1ee3c th\u1ef1c hi\u1ec7n nh\u1eb1m \u0111\u01b0a ra k\u1ebft lu\u1eadn cho \u0111\u1ebfn hi\u1ec7n t\u1ea1i r\u1eb1ng Teriparatide v\u01b0\u1ee3t tr\u1ed9i so v\u1edbi Risedronate trong \u0111i\u1ec1u tr\u1ecb lo\u00e3ng x\u01b0\u01a1ng v\u00ec l\u00e0m t\u0103ng m\u1eadt \u0111\u1ed9 ch\u1ea5t kho\u00e1ng x\u01b0\u01a1ng \u1edf nhi\u1ec1u v\u1ecb tr\u00ed nh\u01b0 c\u1ed9t s\u1ed1ng th\u1eaft l\u01b0ng, c\u1ed5 x\u01b0\u01a1ng \u0111\u00f9i v\u00e0 to\u00e0n b\u1ed9 x\u01b0\u01a1ng h\u00f4ng c\u0169ng nh\u01b0 l\u00e0m gi\u1ea3m nguy c\u01a1 g\u00e3y x\u01b0\u01a1ng.<\/span><\/p>\n

 <\/p>\n","protected":false},"excerpt":{"rendered":"

Teriparatide v\u00e0 Risedronate l\u00e0 hai lo\u1ea1i thu\u1ed1c \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng \u0111\u1ec3 \u0111i\u1ec1u tr\u1ecb lo\u00e3ng x\u01b0\u01a1ng. Teriparatide l\u00e0 m\u1ed9t lo\u1ea1i thu\u1ed1c k\u00edch th\u00edch t\u1ea1o ra x\u01b0\u01a1ng m\u1edbi, trong khi Risedronate l\u00e0 m\u1ed9t bisphosphonate, c\u00f3 t\u00e1c d\u1ee5ng ng\u0103n ch\u1eb7n s\u1ef1 ph\u00e2n h\u1ee7y x\u01b0\u01a1ng. Hi\u1ec7u qu\u1ea3 c\u1ee7a c\u1ea3 hai lo\u1ea1i thu\u1ed1c \u0111\u00e3 \u0111\u01b0\u1ee3c ch\u1ee9ng minh trong nhi\u1ec1u nghi\u00ean […]<\/p>\n","protected":false},"author":54,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[12],"tags":[],"yoast_head":"\nSo s\u00e1nh Teriparatide v\u00e0 Risedronate trong \u0111i\u1ec1u tr\u1ecb lo\u00e3ng x\u01b0\u01a1ng<\/title>\n<meta name=\"description\" content=\"M\u1eb7c d\u00f9 c\u1ea3 Teriparatide v\u00e0 Risedronate \u0111\u1ec1u ph\u00e1t huy hi\u1ec7u qu\u1ea3 trong \u0111i\u1ec1u tr\u1ecb lo\u00e3ng x\u01b0\u01a1ng nh\u01b0ng s\u1ef1 kh\u00e1c bi\u1ec7t c\u01a1 ch\u1ebf d\u1eabn \u0111\u1ebfn kh\u00e1c nhau hi\u1ec7u qu\u1ea3\" \/>\n<meta name=\"robots\" content=\"noindex, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" 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