{"id":24569,"date":"2023-04-21T10:43:16","date_gmt":"2023-04-21T03:43:16","guid":{"rendered":"http:\/\/noithathoaphat.in\/ctv\/?p=24569"},"modified":"2023-04-21T11:28:25","modified_gmt":"2023-04-21T04:28:25","slug":"phat-hien-moi-bexagliflozin-trong-dieu-tri-dai-thao-duong-loai-2","status":"publish","type":"post","link":"http:\/\/noithathoaphat.in\/ctv\/index.php\/2023\/04\/21\/phat-hien-moi-bexagliflozin-trong-dieu-tri-dai-thao-duong-loai-2\/","title":{"rendered":"Ph\u00e1t hi\u1ec7n m\u1edbi Bexagliflozin trong \u0111i\u1ec1u tr\u1ecb \u0110\u00e1i Th\u00e1o \u0110\u01b0\u1eddng lo\u1ea1i 2"},"content":{"rendered":"

Bexagliflozin l\u00e0 m\u1ed9t lo\u1ea1i thu\u1ed1c m\u1edbi \u0111\u01b0\u1ee3c ph\u00e1t hi\u1ec7n trong \u0111i\u1ec1u tr\u1ecb \u0111\u00e1i th\u00e1o \u0111\u01b0\u1eddng lo\u1ea1i 2. \u0110i\u1ec1u n\u00e0y \u0111ang thu h\u00fat s\u1ef1 ch\u00fa \u00fd c\u1ee7a c\u1ed9ng \u0111\u1ed3ng y t\u1ebf do \u0111\u00e1i th\u00e1o \u0111\u01b0\u1eddng lo\u1ea1i 2 \u0111ang tr\u1edf th\u00e0nh m\u1ed9t v\u1ea5n \u0111\u1ec1 s\u1ee9c kh\u1ecfe l\u1edbn tr\u00ean to\u00e0n th\u1ebf gi\u1edbi. Bexagliflozin l\u00e0 m\u1ed9t lo\u1ea1i thu\u1ed1c \u1ee9c ch\u1ebf t\u00e1i h\u1ea5p thu \u0111\u01b0\u1eddng v\u00e0 gi\u00fap gi\u1ea3m \u0111\u01b0\u1eddng huy\u1ebft b\u1eb1ng c\u00e1ch lo\u1ea1i b\u1ecf \u0111\u01b0\u1eddng trong n\u01b0\u1edbc ti\u1ec3u. \u0110i\u1ec1u n\u00e0y gi\u00fap c\u1ea3i thi\u1ec7n \u0111\u00e1ng k\u1ec3 s\u1ef1 \u0111i\u1ec1u ti\u1ebft \u0111\u01b0\u1eddng trong c\u01a1 th\u1ec3 v\u00e0 gi\u1ea3m nguy c\u01a1 c\u00e1c bi\u1ebfn ch\u1ee9ng c\u1ee7a b\u1ec7nh \u0111\u00e1i th\u00e1o \u0111\u01b0\u1eddng lo\u1ea1i 2. Vi\u1ec7c ph\u00e1t hi\u1ec7n ra thu\u1ed1c m\u1edbi n\u00e0y \u0111ang m\u1edf ra m\u1ed9t c\u00e1nh c\u1eeda m\u1edbi trong \u0111i\u1ec1u tr\u1ecb \u0111\u00e1i th\u00e1o \u0111\u01b0\u1eddng lo\u1ea1i 2 v\u00e0 g\u00f3p ph\u1ea7n c\u1ea3i thi\u1ec7n ch\u1ea5t l\u01b0\u1ee3ng cu\u1ed9c s\u1ed1ng c\u1ee7a nh\u1eefng ng\u01b0\u1eddi b\u1ec7nh.<\/strong><\/p>\n

1.Gi\u1edbi thi\u1ec7u\u00a0<\/strong><\/h2>\n

V\u00e0o n\u0103m 2023, Bexagliflozin \u0111\u00e3 \u0111\u01b0\u1ee3c C\u1ee5c qu\u1ea3n l\u00fd Th\u1ef1c ph\u1ea9m v\u00e0 D\u01b0\u1ee3c ph\u1ea9m Hoa K\u1ef3 (FDA) ph\u00ea duy\u1ec7t d\u01b0\u1edbi t\u00ean bi\u1ec7t d\u01b0\u1ee3c l\u00e0 Brenzavvy trong \u0111i\u1ec1u tr\u1ecb \u0111\u00e1i th\u00e1o \u0111\u01b0\u1eddng lo\u1ea1i 2<\/a> \u1edf ng\u01b0\u1eddi l\u1edbn. S\u1ef1 ch\u1ea5p thu\u1eadn d\u1ef1a tr\u00ean k\u1ebft qu\u1ea3 t\u1eeb m\u1ed9t ch\u01b0\u01a1ng tr\u00ecnh l\u00e2m s\u00e0ng \u0111\u00e1nh gi\u00e1 t\u00ednh an to\u00e0n v\u00e0 hi\u1ec7u qu\u1ea3 c\u1ee7a Bexaglifozin trong 23 th\u1eed nghi\u1ec7m l\u00e2m s\u00e0ng v\u1edbi h\u01a1n 5000 ng\u01b0\u1eddi tr\u01b0\u1edfng th\u00e0nh m\u1eafc b\u1ec7nh ti\u1ec3u \u0111\u01b0\u1eddng lo\u1ea1i 2. C\u00e1c nghi\u00ean c\u1ee9u \u1edf giai \u0111o\u1ea1n 3 cho th\u1ea5y ph\u01b0\u01a1ng ph\u00e1p \u0111i\u1ec1u tr\u1ecb l\u00e0m gi\u1ea3m \u0111\u00e1ng k\u1ec3 HbA1c v\u00e0 l\u01b0\u1ee3ng \u0111\u01b0\u1eddng trong m\u00e1u l\u00fac \u0111\u00f3i sau 24 tu\u1ea7n d\u01b0\u1edbi d\u1ea1ng \u0111\u01a1n tr\u1ecb li\u1ec7u, k\u1ebft h\u1ee3p v\u1edbi Metformin ho\u1eb7c b\u1ed5 sung cho \u0111i\u1ec1u tr\u1ecb tr\u1ecb ch\u0103m s\u00f3c ti\u00eau chu\u1ea9n v\u1edbi nhi\u1ec1u ph\u00e1c \u0111\u1ed3 kh\u00e1c nhau, ch\u1eb3ng h\u1ea1n nh\u01b0 Metformin, Sulfonylurea, Insulin, thu\u1ed1c \u1ee9c ch\u1ebf DPP4 ho\u1eb7c k\u1ebft h\u1ee3p c\u00e1c thu\u1ed1c n\u00e0y<\/span><\/p>\n

\"Bexagliflozin
Bexagliflozin v\u00e0 bi\u1ec7t d\u01b0\u1ee3c Brenzavvy<\/figcaption><\/figure>\n

2.Ch\u1ec9 \u0111\u1ecbnh v\u00e0 c\u01a1 ch\u1ebf ho\u1ea1t \u0111\u1ed9ng c\u1ee7a Bexagliflozin<\/strong><\/h2>\n

Bexagliflozin \u0111\u01b0\u1eddng u\u1ed1ng ch\u1ec9 \u0111\u1ecbnh s\u1eed d\u1ee5ng trong vi\u1ec7c h\u1ed7 tr\u1ee3 cho ch\u1ebf \u0111\u1ed9 \u0103n ki\u00eang v\u00e0 t\u1eadp th\u1ec3 d\u1ee5c \u0111\u1ec3 c\u1ea3i thi\u1ec7n ch\u1ec9 s\u1ed1 \u0111\u01b0\u1eddng huy\u1ebft \u1edf nh\u1eefng ng\u01b0\u1eddi tr\u01b0\u1edfng th\u00e0nh m\u1eafc b\u1ec7nh \u0111\u00e1i th\u00e1o \u0111\u01b0\u1eddng lo\u1ea1i 2<\/span><\/p>\n

Bexagliflozin l\u00e0 ch\u1ea5t \u1ee9c ch\u1ebf \u0111\u1ed3ng v\u1eadn chuy\u1ec3n natri-glucose 2 (SGLT2) c\u00f3 t\u00ednh ch\u1ecdn l\u1ecdc cao. SGLT2 n\u1eb1m trong \u1ed1ng l\u01b0\u1ee3n g\u1ea7n, l\u00e0m trung gian t\u00e1i h\u1ea5p thu kho\u1ea3ng 90% l\u01b0\u1ee3ng Glucose \u0111\u01b0\u1ee3c l\u1ecdc v\u00e0 v\u1eadn chuy\u1ec3n t\u1eeb l\u00f2ng \u1ed1ng th\u1eadn \u0111\u1ebfn bi\u1ec3u m\u00f4. B\u1eb1ng c\u00e1ch \u1ee9c ch\u1ebf SGLT2, Bexagliflozin l\u00e0m gi\u1ea3m t\u00e1i h\u1ea5p thu Glucose \u1edf th\u1eadn v\u00e0 th\u00fac \u0111\u1ea9y b\u00e0i ti\u1ebft Glucose qua n\u01b0\u1edbc ti\u1ec3u. Do \u0111\u00f3, \u1edf nh\u1eefng b\u1ec7nh nh\u00e2n \u0111\u00e1i th\u00e1o \u0111\u01b0\u1eddng lo\u1ea1i 2, Bexagliflozin l\u00e0m gi\u1ea3m l\u01b0\u1ee3ng \u0111\u01b0\u1eddng trong m\u00e1u m\u00e0 kh\u00f4ng k\u00edch th\u00edch gi\u1ea3i ph\u00f3ng Insulin<\/span><\/p>\n

\"C\u01a1
C\u01a1 ch\u1ebf c\u1ee7a Bexagliflozin<\/figcaption><\/figure>\n

3.D\u01b0\u1ee3c \u0111\u1ed9ng h\u1ecdc c\u1ee7a Bexagliflozin<\/strong><\/h2>\n

C\u00e1c \u0111\u1ed1i t\u01b0\u1ee3ng kh\u1ecfe m\u1ea1nh v\u00e0 b\u1ec7nh nh\u00e2n tr\u01b0\u1edfng th\u00e0nh b\u1ecb \u0111\u00e1i th\u00e1o \u0111\u01b0\u1eddng t\u00fdp 2 d\u00f9ng Bexagliflozin c\u00f3 \u0111\u1eb7c \u0111i\u1ec3m d\u01b0\u1ee3c \u0111\u1ed9ng h\u1ecdc t\u01b0\u01a1ng t\u1ef1 nhau<\/span><\/p>\n

3.1 H\u1ea5p thu\u00a0<\/span><\/h3>\n

\u1ede tr\u1ea1ng th\u00e1i \u0111\u00f3i, gi\u00e1 tr\u1ecb trung b\u00ecnh c\u1ee7a Cmax v\u00e0 AUC c\u1ee7a Bexagliflozin l\u1ea7n l\u01b0\u1ee3t l\u00e0 134 ng\/mL v\u00e0 1162 ng\u00b7h\/mL. N\u1ed3ng \u0111\u1ed9 t\u1ed1i \u0111a \u0111\u1ea1t \u0111\u01b0\u1ee3c trong huy\u1ebft t\u01b0\u01a1ng c\u1ee7a Bexagliflozin trong kho\u1ea3ng 2-4 sau khi u\u1ed1ng. Khi s\u1eed d\u1ee5ng li\u1ec1u \u0111\u01a1n trong kho\u1ea3ng 3mg-90mg (g\u1ea5p 0,15 \u0111\u1ebfn 4,5 l\u1ea7n li\u1ec1u khuy\u1ebfn c\u00e1o), Cmax v\u00e0 AUC trong huy\u1ebft t\u01b0\u01a1ng c\u1ee7a Bexagliflozin t\u0103ng t\u1ec9 l\u1ec7 thu\u1eadn v\u1edbi li\u1ec1u d\u00f9ng. So v\u1edbi vi\u1ec7c d\u00f9ng thu\u1ed1c khi \u0111\u00f3i, u\u1ed1ng Bexagliflozin sau b\u1eefa \u0103n gi\u00e0u ch\u1ea5t b\u00e9o nhi\u1ec1u calo d\u1eabn \u0111\u1ebfn Cmax v\u00e0 AUC cao h\u01a1n l\u1ea7n l\u01b0\u1ee3t l\u00e0 31% v\u00e0 10% v\u00e0 Tmax trung b\u00ecnh t\u0103ng l\u00ean 5 gi\u1edd<\/span><\/p>\n

3.2 Ph\u00e2n b\u1ed1\u00a0<\/span><\/h3>\n

Bexagliflozin c\u00f3 th\u1ec3 t\u00edch ph\u00e2n b\u1ed1 bi\u1ec3u ki\u1ebfn (Vd) \u200b\u200bl\u00e0 262L n\u00ean ph\u00e2n b\u1ed1 nhi\u1ec1u trong c\u01a1 th\u1ec3 \u00edt ph\u00e2n b\u1ed1 trong huy\u1ebft t\u01b0\u01a1ng<\/span><\/p>\n

3.3 Chuy\u1ec3n h\u00f3a<\/span><\/h3>\n

Trong huy\u1ebft t\u01b0\u01a1ng, kho\u1ea3ng 93% Bexagliflozin li\u00ean k\u1ebft v\u1edbi protein huy\u1ebft t\u01b0\u01a1ng. Do t\u1ec9 l\u1ec7 thu\u1ed1c li\u00ean k\u1ebft v\u1edbi protein huy\u1ebft t\u01b0\u01a1ng l\u1edbn n\u00ean t\u1ed3n t\u1ea1i l\u00e2u trong c\u01a1 th\u1ec3 l\u00e2u v\u00e0 cho t\u00e1c d\u1ee5ng k\u00e9o d\u00e0i h\u01a1n. Bexagliflozin \u0111\u01b0\u1ee3c chuy\u1ec3n h\u00f3a \u1edf gan ch\u1ee7 y\u1ebfu b\u1edfi UGT1A9 v\u00e0 m\u1ed9t ph\u1ea7n b\u1edfi CYP3A<\/span><\/p>\n

3.4 Th\u1ea3i tr\u1eeb\u00a0<\/span><\/h3>\n

Bexagliflozin \u0111\u01b0\u1ee3c th\u1ea3i tr\u1eeb ch\u1ee7 y\u1ebfu qua ph\u00e2n v\u00e0 n\u01b0\u1edbc ti\u1ec3u, c\u00f3 th\u1eddi gian b\u00e1n h\u1ee7y (T1\/2) \u1edf giai \u0111o\u1ea1n cu\u1ed1i kho\u1ea3ng 12 gi\u1edd v\u00e0 \u0111\u1ed9 thanh th\u1ea3i (Cl) l\u00e0 19,1L\/gi\u1edd<\/span><\/p>\n

4.T\u00e1c d\u1ee5ng ph\u1ee5 v\u00e0 ch\u1ed1ng ch\u1ec9 \u0111\u1ecbnh c\u1ee7a Bexagliflozin<\/strong><\/h2>\n

C\u00e1c ph\u1ea3n \u1ee9ng b\u1ea5t l\u1ee3i quan tr\u1ecdng khi s\u1eed d\u1ee5ng Bexagliflozin bao g\u1ed3m: nhi\u1ec5m toan ceton, t\u0103ng nguy c\u01a1 c\u1eaft c\u1ee5t chi d\u01b0\u1edbi, vi\u00eam b\u1ec3 th\u1eadn, h\u1ea1 \u0111\u01b0\u1eddng huy\u1ebft qu\u00e1 m\u1ee9c, nhi\u1ec5m n\u1ea5m \u0111\u01b0\u1eddng sinh d\u1ee5c, nhi\u1ec5m tr\u00f9ng ni\u1ec7u \u0111\u1ea1o, ti\u1ebft d\u1ecbch \u00e2m \u0111\u1ea1o b\u1ea5t th\u01b0\u1eddng, bu\u1ed3n n\u00f4n, n\u00f4n, s\u1ed1t,…<\/span><\/p>\n

Bexagliflozin kh\u00f4ng \u0111\u01b0\u1ee3c k\u00ea \u0111\u01a1n s\u1eed d\u1ee5ng cho c\u00e1c \u0111\u1ed1i t\u01b0\u1ee3ng sau: b\u1ec7nh th\u1eadn, gan n\u1eb7ng, bi\u1ebfn ch\u1ee9ng nhi\u1ec5m toan ceton do \u0111\u00e1i th\u00e1o \u0111\u01b0\u1eddng, ti\u1ec1n s\u1eed c\u1eaft c\u1ee5t chi, lo\u00e9t ch\u00e2n do \u0111\u00e1i th\u00e1o \u0111\u01b0\u1eddng, b\u1ec7nh tim, c\u00e1c v\u1ea5n \u0111\u1ec1 v\u1ec1 h\u1ec7 tu\u1ea7n ho\u00e0n ho\u1eb7c t\u1ed5n th\u01b0\u01a1ng th\u1ea7n kinh, d\u1ecb \u1ee9ng n\u1eb7ng, \u0111ang s\u1eed d\u1ee5ng thu\u1ed1c huy\u1ebft \u00e1p, \u0111\u00e1i th\u00e1o \u0111\u01b0\u1eddng lo\u1ea1i 1<\/span><\/p>\n

5.C\u1ea3nh b\u00e1o v\u00e0 th\u1eadn tr\u1ecdng khi s\u1eed d\u1ee5ng Bexagliflozin<\/strong><\/h2>\n

5.1 Nhi\u1ec5m toan ceton\u00a0<\/span><\/h3>\n

C\u00e1c b\u00e1o c\u00e1o v\u1ec1 nhi\u1ec5m toan ceton, m\u1ed9t t\u00ecnh tr\u1ea1ng nghi\u00eam tr\u1ecdng \u0111e d\u1ecda \u0111\u1ebfn t\u00ednh m\u1ea1ng c\u1ea7n nh\u1eadp vi\u1ec7n kh\u1ea9n c\u1ea5p, \u0111\u00e3 \u0111\u01b0\u1ee3c x\u00e1c \u0111\u1ecbnh trong c\u00e1c th\u1eed nghi\u1ec7m l\u00e2m s\u00e0ng v\u00e0 gi\u00e1m s\u00e1t sau khi \u0111\u01b0a thu\u1ed1c ra th\u1ecb tr\u01b0\u1eddng \u1edf b\u1ec7nh nh\u00e2n \u0111\u00e1i th\u00e1o \u0111\u01b0\u1eddng lo\u1ea1i 1 v\u00e0 2 \u0111\u00e3 d\u00f9ng thu\u1ed1c. B\u1ec7nh nh\u00e2n \u0111\u01b0\u1ee3c \u0111i\u1ec1u tr\u1ecb b\u1eb1ng Brenzavvy c\u00f3 c\u00e1c d\u1ea5u hi\u1ec7u v\u00e0 tri\u1ec7u ch\u1ee9ng ph\u00f9 h\u1ee3p v\u1edbi nhi\u1ec5m toan chuy\u1ec3n h\u00f3a n\u1eb7ng n\u00ean \u0111\u01b0\u1ee3c \u0111\u00e1nh gi\u00e1 nhi\u1ec5m toan ceton b\u1ea5t k\u1ec3 m\u1ee9c \u0111\u01b0\u1eddng huy\u1ebft v\u00ec nhi\u1ec5m toan ceton li\u00ean quan \u0111\u1ebfn Brenzavvy c\u00f3 th\u1ec3 xu\u1ea5t hi\u1ec7n ngay c\u1ea3 khi m\u1ee9c \u0111\u01b0\u1eddng huy\u1ebft d\u01b0\u1edbi 250 mg\/dL. N\u1ebfu nghi ng\u1edd nhi\u1ec5m toan ceton, n\u00ean ng\u1eebng s\u1eed d\u1ee5ng Brenzavvy, \u0111\u00e1nh gi\u00e1 b\u1ec7nh nh\u00e2n v\u00e0 ti\u1ebfn h\u00e0nh \u0111i\u1ec1u tr\u1ecb ngay. C\u00e1c d\u1ea5u hi\u1ec7u v\u00e0 tri\u1ec7u ch\u1ee9ng khi tr\u00ecnh b\u00e0y ph\u00f9 h\u1ee3p v\u1edbi t\u00ecnh tr\u1ea1ng m\u1ea5t n\u01b0\u1edbc v\u00e0 toan chuy\u1ec3n h\u00f3a n\u1eb7ng, bao g\u1ed3m bu\u1ed3n n\u00f4n, n\u00f4n, \u0111au b\u1ee5ng, kh\u00f3 ch\u1ecbu to\u00e0n th\u00e2n v\u00e0 kh\u00f3 th\u1edf<\/span><\/p>\n

5.2 T\u0103ng t\u1ec9 l\u1ec7 c\u1eaft c\u1ee5t chi d\u01b0\u1edbi<\/span><\/h3>\n

Nghi\u00ean c\u1ee9u cho k\u1ebft qu\u1ea3 trong s\u1ed123 b\u1ec7nh nh\u00e2n \u0111\u01b0\u1ee3c \u0111i\u1ec1u tr\u1ecb b\u1eb1ng Brenzavvy b\u1ecb c\u1eaft c\u1ee5t chi, 15 ng\u01b0\u1eddi b\u1ecb c\u1eaft c\u1ee5t ng\u00f3n ch\u00e2n v\u00e0 gi\u1eefa b\u00e0n ch\u00e2n v\u00e0 8 ng\u01b0\u1eddi b\u1ecb c\u1eaft c\u1ee5t tr\u00ean v\u00e0 d\u01b0\u1edbi \u0111\u1ea7u g\u1ed1i v\u00e0 m\u1ed9t s\u1ed1 b\u1ec7nh nh\u00e2n b\u1ecb c\u1eaft c\u1ee5t nhi\u1ec1u chi.Theo d\u00f5i b\u1ec7nh nh\u00e2n d\u00f9ng Brenzavvy \u0111\u1ec3 bi\u1ebft c\u00e1c d\u1ea5u hi\u1ec7u v\u00e0 tri\u1ec7u ch\u1ee9ng nhi\u1ec5m tr\u00f9ng (bao g\u1ed3m c\u1ea3 vi\u00eam t\u1ee7y x\u01b0\u01a1ng), \u0111au ho\u1eb7c \u0111au m\u1edbi, v\u1ebft lo\u00e9t ho\u1eb7c v\u1ebft lo\u00e9t \u1edf chi d\u01b0\u1edbi v\u00e0 ng\u1eebng s\u1eed d\u1ee5ng n\u1ebfu c\u00e1c bi\u1ebfn ch\u1ee9ng n\u00e0y x\u1ea3y ra<\/span><\/p>\n

5.3 Suy gi\u1ea3m th\u1ec3 t\u00edch\u00a0<\/span><\/h3>\n

Brenzavvy c\u00f3 th\u1ec3 g\u00e2y co th\u1ec3 t\u00edch trong l\u00f2ng m\u1ea1ch, \u0111\u00f4i khi c\u00f3 th\u1ec3 bi\u1ec3u hi\u1ec7n d\u01b0\u1edbi d\u1ea1ng h\u1ea1 huy\u1ebft \u00e1p c\u00f3 tri\u1ec7u ch\u1ee9ng ho\u1eb7c thay \u0111\u1ed5i Creatinine tho\u00e1ng qua c\u1ea5p t\u00ednh.\u1ede nh\u1eefng b\u1ec7nh <\/span>nh\u00e2n b\u1ecb suy gi\u1ea3m th\u1ec3 t\u00edch tu\u1ea7n ho\u00e0n, h\u00e3y kh\u1eafc ph\u1ee5c t\u00ecnh tr\u1ea1ng n\u00e0y tr\u01b0\u1edbc khi b\u1eaft \u0111\u1ea7u d\u00f9ng thu\u1ed1c. Theo d\u00f5i c\u00e1c d\u1ea5u hi\u1ec7u v\u00e0 tri\u1ec7u ch\u1ee9ng c\u1ee7a gi\u1ea3m th\u1ec3 t\u00edch tu\u1ea7n ho\u00e0n v\u00e0 ch\u1ee9c n\u0103ng th\u1eadn sau khi b\u1eaft \u0111\u1ea7u \u0111i\u1ec1u tr\u1ecb.\u00a0<\/span><\/p>\n

5.4 Nhi\u1ec5m tr\u00f9ng ni\u1ec7u v\u00e0 vi\u00eam b\u1ec3 th\u1eadn\u00a0<\/span><\/h3>\n

C\u00f3 b\u00e1o c\u00e1o v\u1ec1 c\u00e1c tr\u01b0\u1eddng h\u1ee3p nhi\u1ec5m tr\u00f9ng \u0111\u01b0\u1eddng ti\u1ebft ni\u1ec7u nghi\u00eam tr\u1ecdng, bao g\u1ed3m nhi\u1ec5m tr\u00f9ng ni\u1ec7u v\u00e0 vi\u00eam b\u1ec3 th\u1eadn, c\u1ea7n ph\u1ea3i nh\u1eadp vi\u1ec7n \u1edf nh\u1eefng b\u1ec7nh nh\u00e2n d\u00f9ng Brenzavvy. \u0110\u00e1nh gi\u00e1 b\u1ec7nh nh\u00e2n v\u1ec1 c\u00e1c d\u1ea5u hi\u1ec7u v\u00e0 tri\u1ec7u ch\u1ee9ng c\u1ee7a nhi\u1ec5m tr\u00f9ng \u0111\u01b0\u1eddng ti\u1ebft ni\u1ec7u v\u00e0 \u0111i\u1ec1u tr\u1ecb k\u1ecbp th\u1eddi<\/span><\/p>\n

5.5 Ho\u1ea1i t\u1eed Fournier<\/span><\/h3>\n

C\u00e1c b\u00e1o c\u00e1o v\u1ec1 ho\u1ea1i t\u1eed Fournier, m\u1ed9t b\u1ec7nh nhi\u1ec5m tr\u00f9ng ho\u1ea1i t\u1eed hi\u1ebfm g\u1eb7p nh\u01b0ng nghi\u00eam tr\u1ecdng v\u00e0 \u0111e d\u1ecda t\u00ednh m\u1ea1ng c\u1ea7n can thi\u1ec7p ph\u1eabu thu\u1eadt kh\u1ea9n c\u1ea5p, \u0111\u00e3 \u0111\u01b0\u1ee3c x\u00e1c \u0111\u1ecbnh trong qu\u00e1 tr\u00ecnh gi\u00e1m s\u00e1t sau khi \u0111\u01b0a thu\u1ed1c ra th\u1ecb tr\u01b0\u1eddng \u1edf b\u1ec7nh nh\u00e2n \u0111\u00e1i th\u00e1o \u0111\u01b0\u1eddng \u0111ang d\u00f9ng thu\u1ed1c Brenzavvy. B\u1ec7nh nh\u00e2n \u0111\u01b0\u1ee3c \u0111i\u1ec1u tr\u1ecb b\u1eb1ng thu\u1ed1c c\u00f3 bi\u1ec3u hi\u1ec7n \u0111au ho\u1eb7c nh\u1ea1y c\u1ea3m, ban \u0111\u1ecf ho\u1eb7c s\u01b0ng \u1edf v\u00f9ng sinh d\u1ee5c ho\u1eb7c v\u00f9ng \u0111\u00e1y ch\u1eadu, c\u00f9ng v\u1edbi s\u1ed1t ho\u1eb7c kh\u00f3 ch\u1ecbu, n\u00ean \u0111\u01b0\u1ee3c \u0111\u00e1nh gi\u00e1 v\u1ec1 b\u1ec7nh vi\u00eam c\u00e2n ho\u1ea1i t\u1eed. N\u1ebfu nghi ng\u1edd, b\u1eaft \u0111\u1ea7u \u0111i\u1ec1u tr\u1ecb ngay l\u1eadp t\u1ee9c b\u1eb1ng kh\u00e1ng sinh ph\u1ed5 r\u1ed9ng n\u1ebfu c\u1ea7n thi\u1ebft, ph\u1eabu thu\u1eadt c\u1eaft l\u1ecdc. Ng\u1eebng s\u1eed d\u1ee5ng thu\u1ed1c v\u00e0 sau khi theo d\u00f5i ch\u1eb7t ch\u1ebd l\u01b0\u1ee3ng \u0111\u01b0\u1eddng trong m\u00e1u, cung c\u1ea5p li\u1ec7u ph\u00e1p thay th\u1ebf th\u00edch h\u1ee3p \u0111\u1ec3 ki\u1ec3m so\u00e1t \u0111\u01b0\u1eddng huy\u1ebft<\/span><\/p>\n

5.6 Nhi\u1ec5m n\u1ea5m sinh d\u1ee5c\u00a0<\/span><\/h3>\n

Nh\u1eefng b\u1ec7nh nh\u00e2n c\u00f3 ti\u1ec1n s\u1eed nhi\u1ec5m n\u1ea5m sinh d\u1ee5c ho\u1eb7c kh\u00f4ng c\u1eaft bao quy \u0111\u1ea7u c\u00f3 nhi\u1ec1u kh\u1ea3 n\u0103ng t\u0103ng nguy c\u01a1 nhi\u1ec5m n\u1ea5m sinh d\u1ee5c sau d\u00f9ng thu\u1ed1c Brenzavvy n\u00ean c\u1ea7n theo d\u00f5i v\u00e0 \u0111i\u1ec1u tr\u1ecb th\u00edch h\u1ee3p\u00a0<\/span><\/p>\n

6.Li\u1ec1u d\u00f9ng v\u00e0 c\u00e1ch s\u1eed d\u1ee5ng Bexagliflozin trong \u0111i\u1ec1u tr\u1ecb \u0111\u00e1i th\u00e1o \u0111\u01b0\u1eddng lo\u1ea1i 2<\/strong><\/h2>\n

\u0110\u00e1nh gi\u00e1 ch\u1ee9c n\u0103ng th\u1eadn tr\u01b0\u1edbc v\u00e0 sau khi s\u1eed d\u1ee5ng Bexagliflozin. Kh\u00f4ng n\u00ean d\u00f9ng cho b\u1ec7nh nh\u00e2n c\u00f3 eGFR < 30 mL\/ph\u00fat\/1,73 m2<\/span><\/p>\n

Li\u1ec1u d\u00f9ng khuy\u1ebfn ngh\u1ecb: li\u1ec1u l\u01b0\u1ee3ng khuy\u1ebfn c\u00e1o c\u1ee7a Brenzavvy l\u00e0 20mg \/ 1 l\u1ea7n v\u00e0o bu\u1ed5i s\u00e1ng\u00a0<\/span><\/p>\n

Kh\u00f4ng nghi\u1ec1n n\u00e1t ho\u1eb7c nhai vi\u00ean thu\u1ed1c m\u00e0 nu\u1ed1t c\u1ea3 vi\u00ean. N\u1ebfu qu\u00ean u\u1ed1ng, b\u1ed5 sung li\u1ec1u qu\u00ean c\u00e0ng s\u1edbm c\u00e0ng t\u1ed1t m\u00e0 kh\u00f4ng t\u0103ng g\u1ea5p \u0111\u00f4i li\u1ec1u ti\u1ebfp theo\u00a0<\/span><\/p>\n

 <\/p>\n","protected":false},"excerpt":{"rendered":"

Bexagliflozin l\u00e0 m\u1ed9t lo\u1ea1i thu\u1ed1c m\u1edbi \u0111\u01b0\u1ee3c ph\u00e1t hi\u1ec7n trong \u0111i\u1ec1u tr\u1ecb \u0111\u00e1i th\u00e1o \u0111\u01b0\u1eddng lo\u1ea1i 2. \u0110i\u1ec1u n\u00e0y \u0111ang thu h\u00fat s\u1ef1 ch\u00fa \u00fd c\u1ee7a c\u1ed9ng \u0111\u1ed3ng y t\u1ebf do \u0111\u00e1i th\u00e1o \u0111\u01b0\u1eddng lo\u1ea1i 2 \u0111ang tr\u1edf th\u00e0nh m\u1ed9t v\u1ea5n \u0111\u1ec1 s\u1ee9c kh\u1ecfe l\u1edbn tr\u00ean to\u00e0n th\u1ebf gi\u1edbi. Bexagliflozin l\u00e0 m\u1ed9t lo\u1ea1i thu\u1ed1c \u1ee9c […]<\/p>\n","protected":false},"author":54,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[12,33],"tags":[3],"yoast_head":"\nPh\u00e1t hi\u1ec7n m\u1edbi Bexagliflozin trong \u0111i\u1ec1u tr\u1ecb \u0110\u00e1i Th\u00e1o \u0110\u01b0\u1eddng lo\u1ea1i 2<\/title>\n<meta name=\"description\" content=\"Sau th\u1eed nghi\u1ec7m, Bexagliflozin \u0111\u00e3 \u0111\u01b0\u1ee3c ch\u1ea5p thu\u1eadn l\u00e0 m\u1ed9t lo\u1ea1i thu\u1ed1c m\u1edbi \u0111\u01b0\u1ee3c ph\u00e1t hi\u1ec7n trong \u0111i\u1ec1u tr\u1ecb \u0111\u00e1i th\u00e1o \u0111\u01b0\u1eddng lo\u1ea1i 2\" \/>\n<meta name=\"robots\" content=\"noindex, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Ph\u00e1t 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