{"id":23886,"date":"2023-04-22T09:57:06","date_gmt":"2023-04-22T02:57:06","guid":{"rendered":"http:\/\/noithathoaphat.in\/ctv\/?p=23886"},"modified":"2023-04-22T09:57:06","modified_gmt":"2023-04-22T02:57:06","slug":"tuong-tac-thuoc-giua-lithium-va-ibuprofen","status":"publish","type":"post","link":"http:\/\/noithathoaphat.in\/ctv\/index.php\/2023\/04\/22\/tuong-tac-thuoc-giua-lithium-va-ibuprofen\/","title":{"rendered":"T\u01b0\u01a1ng t\u00e1c thu\u1ed1c gi\u1eefa Lithium v\u00e0 Ibuprofen"},"content":{"rendered":"<p><strong>Lithium v\u00e0 Ibuprofen l\u00e0 hai lo\u1ea1i thu\u1ed1c th\u01b0\u1eddng \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng trong \u0111i\u1ec1u tr\u1ecb c\u00e1c b\u1ec7nh l\u00fd kh\u00e1c nhau. Tuy nhi\u00ean, khi s\u1eed d\u1ee5ng \u0111\u1ed3ng th\u1eddi, ch\u00fang c\u00f3 th\u1ec3 t\u01b0\u01a1ng t\u00e1c g\u00e2y t\u0103ng \u0111\u00e1ng k\u1ec3 n\u1ed3ng \u0111\u1ed9 Lithium trong huy\u1ebft thanh, d\u1eabn \u0111\u1ebfn c\u00e1c t\u00e1c d\u1ee5ng ph\u1ee5 nghi\u00eam tr\u1ecdng. \u0110\u1eb7c bi\u1ec7t, ng\u01b0\u1eddi cao tu\u1ed5i v\u00e0 nh\u1eefng ng\u01b0\u1eddi c\u00f3 ti\u1ec1n s\u1eed b\u1ec7nh kh\u00e1c nh\u01b0 suy th\u1eadn c\u1ea7n ph\u1ea3i c\u1ea9n tr\u1ecdng khi s\u1eed d\u1ee5ng hai lo\u1ea1i thu\u1ed1c n\u00e0y \u0111\u1ed3ng th\u1eddi.<\/strong><\/p>\n<h2><strong>1. Th\u00f4ng tin chung v\u1ec1 Lithium v\u00e0 Ibuprofen<\/strong><\/h2>\n<h3><strong>1.1. Lithium<\/strong><\/h3>\n<p><span style=\"font-weight: 400;\">D\u01b0\u1ee3c l\u00fd v\u00e0 c\u01a1 ch\u1ebf t\u00e1c d\u1ee5ng:\u00a0<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Tr\u00ean h\u1ec7 th\u1ea7n kinh, Lithium c\u00f3 t\u00e1c d\u1ee5ng ch\u1ed1ng c\u1ea3 h\u01b0ng c\u1ea3m v\u00e0 tr\u1ea7m c\u1ea3m. C\u01a1 ch\u1ebf t\u00e1c d\u1ee5ng ch\u00ednh x\u00e1c c\u1ee7a Lithium trong \u1ed5n \u0111\u1ecbnh t\u00e2m tr\u00ed ch\u01b0a \u0111\u01b0\u1ee3c bi\u1ebft nh\u01b0ng c\u00f3 th\u1ec3 Lithium c\u1ea1nh tranh v\u1edbi ion Natri (v\u00e0 m\u1ed9t s\u1ed1 ion kh\u00e1c nh\u01b0 Kali, Calci, Magnesi) nh\u01b0ng kh\u00f4ng thay th\u1ebf \u0111\u01b0\u1ee3c Natri trong b\u01a1m Natri v\u00e0 kh\u00f4ng th\u1ec3 duy tr\u00ec \u0111\u01b0\u1ee3c \u0111i\u1ec7n th\u1ebf m\u00e0ng. \u1ede n\u1ed3ng \u0111\u1ed9 \u0111i\u1ec1u tr\u1ecb, Lithium \u1ee9c ch\u1ebf gi\u1ea3i ph\u00f3ng ch\u1ea5t d\u1eabn truy\u1ec1n th\u1ea7n kinh ph\u1ee5 thu\u1ed9c k\u00eanh Calci l\u00e0 Dopamin v\u00e0 Noradrenalin (l\u00e0 nh\u1eefng ch\u1ea5t \u0111\u01b0\u1ee3c coi l\u00e0 c\u00f3 li\u00ean quan \u0111\u1ebfn b\u1ec7nh sinh c\u1ee7a h\u01b0ng c\u1ea3m) v\u00e0 t\u0103ng gi\u1ea3i ph\u00f3ng Serotonin (ch\u1ea5t c\u00f3 li\u00ean quan \u0111\u1ebfn b\u1ec7nh sinh c\u1ee7a tr\u1ea7m c\u1ea3m). Lithium c\u0169ng \u1ee9c ch\u1ebf enzyme inositol monophosphatase (IMPase) t\u1eeb \u0111\u00f3 \u1ee9c ch\u1ebf chuy\u1ec3n h\u00f3a inositol phosphat \u1edf n\u00e3o, do \u0111\u00f3 l\u00e0m gi\u1ea3m l\u01b0\u1ee3ng ch\u1ea5t truy\u1ec1n tin th\u1ee9 hai trong t\u1ebf b\u00e0o. K\u1ebft qu\u1ea3 l\u00e0 l\u00e0m gi\u1ea3m nh\u1ea1y c\u1ea3m c\u1ee7a c\u00e1c n\u01a1ron v\u1edbi c\u00e1c ch\u1ea5t d\u1eabn truy\u1ec1n th\u1ea7n kinh n\u1ed9i sinh.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Lithium l\u00e0m gi\u1ea3m s\u1ef1 nh\u1ea1y c\u1ea3m qu\u00e1 m\u1ee9c c\u1ee7a th\u1ee5 th\u1ec3 Dopamin \u1edf trung \u01b0\u01a1ng th\u1ea7n kinh n\u00ean \u1ee9c ch\u1ebf \u0111\u01b0\u1ee3c m\u1ed9t s\u1ed1 c\u1ea3m x\u00fac qu\u00e1 \u0111\u1ed9 nh\u01b0: Hoang t\u01b0\u1edfng, k\u00edch \u0111\u1ed9ng, n\u00f3i nhi\u1ec1u, m\u1ea5t ng\u1ee7 v\u00e0 t\u00ecnh d\u1ee5c qu\u00e1 \u0111\u1ed9 do c\u00e1c thu\u1ed1c Amphetamin, Cocain g\u00e2y ra.<\/span><\/li>\n<\/ul>\n<figure id=\"attachment_23888\" aria-describedby=\"caption-attachment-23888\" style=\"width: 300px\" class=\"wp-caption aligncenter\"><img decoding=\"async\" loading=\"lazy\" class=\"size-medium wp-image-23888\" src=\"http:\/\/noithathoaphat.in\/ctv\/wp-content\/uploads\/2023\/04\/Lithium-300x180.png\" alt=\"Lithium\" width=\"300\" height=\"180\" srcset=\"http:\/\/noithathoaphat.in\/ctv\/wp-content\/uploads\/2023\/04\/Lithium-300x180.png 300w, http:\/\/noithathoaphat.in\/ctv\/wp-content\/uploads\/2023\/04\/Lithium.png 580w\" sizes=\"(max-width: 300px) 100vw, 300px\" \/><figcaption id=\"caption-attachment-23888\" class=\"wp-caption-text\">Lithium<\/figcaption><\/figure>\n<h3><strong>1.2. Ibuprofen<\/strong><\/h3>\n<p><span style=\"font-weight: 400;\">D\u01b0\u1ee3c l\u00fd v\u00e0 c\u01a1 ch\u1ebf t\u00e1c d\u1ee5ng:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Ibuprofen l\u00e0 thu\u1ed1c ch\u1ed1ng vi\u00eam kh\u00f4ng steroid (NSAID), d\u1eabn xu\u1ea5t t\u1eeb Acid propionic. T\u01b0\u01a1ng t\u1ef1 nh\u01b0 c\u00e1c thu\u1ed1c ch\u1ed1ng vi\u00eam kh\u00f4ng Steroid kh\u00e1c, Ibuprofen c\u00f3 t\u00e1c d\u1ee5ng gi\u1ea3m \u0111au, h\u1ea1 s\u1ed1t v\u00e0 ch\u1ed1ng vi\u00eam. C\u01a1 ch\u1ebf t\u00e1c d\u1ee5ng c\u1ee7a thu\u1ed1c l\u00e0 \u1ee9c ch\u1ebf enzym Prostaglandin Synthetase v\u00e0 do \u0111\u00f3 ng\u0103n t\u1ea1o ra Prostaglandin, Thromboxan v\u00e0 c\u00e1c s\u1ea3n ph\u1ea9m kh\u00e1c c\u1ee7a enzym cyclooxygenase (COX). Ibuprofen c\u0169ng \u1ee9c ch\u1ebf t\u1ed5ng h\u1ee3p Prostacyclin \u1edf th\u1eadn v\u00e0 c\u00f3 th\u1ec3 g\u00e2y nguy c\u01a1 \u1ee9 n\u01b0\u1edbc do l\u00e0m gi\u1ea3m d\u00f2ng m\u00e1u t\u1edbi th\u1eadn. C\u1ea7n ph\u1ea3i l\u01b0u \u00fd \u0111\u1ebfn \u0111i\u1ec1u n\u00e0y khi ch\u1ec9 \u0111\u1ecbnh cho ng\u01b0\u1eddi b\u1ec7nh c\u00f3 suy th\u1eadn, suy tim, suy gan v\u00e0 c\u00e1c b\u1ec7nh c\u00f3 r\u1ed1i lo\u1ea1n v\u1ec1 th\u1ec3 t\u00edch huy\u1ebft t\u01b0\u01a1ng.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">T\u00e1c d\u1ee5ng ch\u1ed1ng vi\u00eam c\u1ee7a Ibuprofen xu\u1ea5t hi\u1ec7n sau hai ng\u00e0y \u0111i\u1ec1u tr\u1ecb. Ibuprofen c\u00f3 t\u00e1c d\u1ee5ng h\u1ea1 s\u1ed1t m\u1ea1nh h\u01a1n Aspirin, nh\u01b0ng k\u00e9m h\u01a1n Indomethacin. Thu\u1ed1c c\u00f3 t\u00e1c d\u1ee5ng ch\u1ed1ng vi\u00eam t\u1ed1t v\u00e0 c\u00f3 t\u00e1c d\u1ee5ng gi\u1ea3m \u0111au t\u1ed1t trong \u0111i\u1ec1u tr\u1ecb vi\u00eam kh\u1edbp d\u1ea1ng th\u1ea5p thi\u1ebfu ni\u00ean.<\/span><\/li>\n<\/ul>\n<figure id=\"attachment_23719\" aria-describedby=\"caption-attachment-23719\" style=\"width: 300px\" class=\"wp-caption aligncenter\"><img decoding=\"async\" loading=\"lazy\" class=\"size-medium wp-image-23719\" src=\"http:\/\/noithathoaphat.in\/ctv\/wp-content\/uploads\/2023\/04\/Ibuprofen-300x200.jpg\" alt=\"Ibuprofen\" width=\"300\" height=\"200\" srcset=\"http:\/\/noithathoaphat.in\/ctv\/wp-content\/uploads\/2023\/04\/Ibuprofen-300x200.jpg 300w, http:\/\/noithathoaphat.in\/ctv\/wp-content\/uploads\/2023\/04\/Ibuprofen.jpg 768w\" sizes=\"(max-width: 300px) 100vw, 300px\" \/><figcaption id=\"caption-attachment-23719\" class=\"wp-caption-text\">Ibuprofen<\/figcaption><\/figure>\n<h2><strong>2. Ch\u1ec9 \u0111\u1ecbnh c\u1ee7a Lithium v\u00e0 Ibuprofen<\/strong><\/h2>\n<h3><strong>2.1. Lithium<\/strong><\/h3>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">D\u1ef1 ph\u00f2ng v\u00e0 \u0111i\u1ec1u tr\u1ecb b\u1ec7nh h\u01b0ng c\u1ea3m, b\u1ec7nh h\u01b0ng c\u1ea3m \u2013 tr\u1ea7m c\u1ea3m v\u00e0 tr\u1ea7m c\u1ea3m t\u00e1i ph\u00e1t.<\/span><\/li>\n<\/ul>\n<h3><strong>2.2. Ibuprofen<\/strong><\/h3>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Gi\u1ea3m \u0111au v\u00e0 ch\u1ed1ng vi\u00eam t\u1eeb nh\u1eb9 \u0111\u1ebfn v\u1eeba: Trong m\u1ed9t s\u1ed1 b\u1ec7nh nh\u01b0 \u0111au \u0111\u1ea7u, \u0111au r\u0103ng. D\u00f9ng Ibuprofen c\u00f3 th\u1ec3 gi\u1ea3m b\u1edbt li\u1ec1u thu\u1ed1c ch\u1ee9a thu\u1ed1c phi\u1ec7n trong \u0111i\u1ec1u tr\u1ecb \u0111au sau \u0111\u1ea1i ph\u1eabu thu\u1eadt hay \u0111au do ung th\u01b0. Vi\u00eam kh\u1edbp d\u1ea1ng th\u1ea5p, vi\u00eam kh\u1edbp d\u1ea1ng th\u1ea5p thi\u1ebfu ni\u00ean.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">H\u1ea1 s\u1ed1t \u1edf tr\u1ebb em.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Ch\u1ee9ng c\u00f2n \u1ed1ng \u0111\u1ed9ng m\u1ea1ch (PDA) \u1edf tr\u1ebb s\u01a1 sinh thi\u1ebfu th\u00e1ng, d\u01b0\u1edbi 34 tu\u1ea7n. <\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">\u0110au b\u1ee5ng kinh.<\/span><\/li>\n<\/ul>\n<h2><strong>3. T\u01b0\u01a1ng t\u00e1c gi\u1eefa Lithium v\u00e0 Ibuprofen<\/strong><\/h2>\n<p><span style=\"font-weight: 400;\">D\u00f9ng \u0111\u1ed3ng th\u1eddi v\u1edbi thu\u1ed1c ch\u1ed1ng vi\u00eam kh\u00f4ng steroid (NSAID) c\u00f3 th\u1ec3 l\u00e0m t\u0103ng n\u1ed3ng \u0111\u1ed9 Lithium trong huy\u1ebft thanh v\u00e0 g\u00e2y \u0111\u1ed9c t\u00ednh \u1edf m\u1ed9t s\u1ed1 b\u1ec7nh nh\u00e2n. C\u01a1 ch\u1ebf t\u01b0\u01a1ng t\u00e1c ch\u00ednh x\u00e1c ch\u01b0a \u0111\u01b0\u1ee3c bi\u1ebft, nh\u01b0ng \u0111\u01b0\u1ee3c cho l\u00e0 c\u00f3 li\u00ean quan \u0111\u1ebfn s\u1ef1 \u1ee9c ch\u1ebf t\u1ed5ng h\u1ee3p Prostaglandin \u1edf th\u1eadn b\u1edfi NSAID, d\u1eabn \u0111\u1ebfn gi\u1ea3m l\u01b0u l\u01b0\u1ee3ng m\u00e1u \u0111\u1ebfn th\u1eadn v\u00e0 b\u00e0i ti\u1ebft Lithium.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">M\u1ee9c \u0111\u1ed9 t\u01b0\u01a1ng t\u00e1c t\u1eeb nhi\u1ec1u ngu\u1ed3n kh\u00e1c nhau:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Drug: nghi\u00eam tr\u1ecdng<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">WebMD: nghi\u00eam tr\u1ecdng<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Medscape: nghi\u00eam tr\u1ecdng<\/span><\/li>\n<\/ul>\n<h2><strong>4. T\u00e1c d\u1ee5ng ph\u1ee5<\/strong><\/h2>\n<h3><strong>4.1 T\u00e1c d\u1ee5ng ph\u1ee5 c\u1ee7a Lithium<\/strong><\/h3>\n<p><b><i>Th\u01b0\u1eddng g\u1eb7p:<\/i><\/b><span style=\"font-weight: 400;\"> Hoa m\u1eaft, ch\u00f3ng m\u1eb7t, bu\u1ed3n ng\u1ee7, ch\u1eadm t\u00e2m l\u00fd \u2013 v\u1eadn \u0111\u1ed9ng, \u0111\u1ee9ng ng\u1ed3i kh\u00f4ng y\u00ean, l\u00fa l\u1eabn, s\u1eefng s\u1edd, \u00f9 tai, \u1ea3o gi\u00e1c, tr\u00ed nh\u1edb k\u00e9m, ho\u1ea1t \u0111\u1ed9ng tr\u00ed l\u1ef1c ch\u1eadm, hay gi\u1eadt m\u00ecnh, h\u1ed9i ch\u1ee9ng n\u00e3o th\u1ef1c th\u1ec3 x\u1ea5u \u0111i, ch\u00e1n \u0103n, bu\u1ed3n n\u00f4n, n\u00f4n, \u1ec9a ch\u1ea3y, vi\u00eam d\u1ea1 d\u00e0y, vi\u00eam tuy\u1ebfn n\u01b0\u1edbc b\u1ecdt, \u0111au b\u1ee5ng, ti\u1ebft nhi\u1ec1u n\u01b0\u1edbc b\u1ecdt, \u0111\u1ea7y h\u01a1i, kh\u00f3 ti\u00eau, kh\u00f4 mi\u1ec7ng, glucose ni\u1ec7u, gi\u1ea3m \u0111\u1ed9 thanh th\u1ea3i creatinin, albumin ni\u1ec7u v\u00e0 c\u00e1c tri\u1ec7u ch\u1ee9ng c\u1ee7a \u0111\u00e1i th\u00e1o nh\u1ea1t do th\u1eadn g\u1ed3m c\u00f3 \u0111\u00e1i nhi\u1ec1u, kh\u00e1t v\u00e0 ch\u1ee9ng kh\u00e1t nhi\u1ec1u, b\u1ea5t l\u1ef1c (r\u1ed1i lo\u1ea1n t\u00ecnh d\u1ee5c).<\/span><\/p>\n<p><span style=\"font-weight: 400;\">\u00a0<\/span><b><i>\u00cdt g\u1eb7p:<\/i><\/b><span style=\"font-weight: 400;\"> Nh\u1ee9c \u0111\u1ea7u, s\u1ed1t, c\u00f3 v\u1ecb kim lo\u1ea1i, lo\u1ea1n v\u1ecb gi\u00e1c, c\u00f3 v\u1ecb m\u1eb7n, t\u1ee9c ng\u1ef1c, run r\u1ea9y, r\u1ed1i lo\u1ea1n \u0111i\u1ec1u ph\u1ed1i, m\u00faa v\u1eddn, m\u00faa gi\u1eadt, t\u0103ng ph\u1ea3n x\u1ea1 g\u00e2n x\u01b0\u01a1ng, c\u00e1c tri\u1ec7u ch\u1ee9ng ngo\u1ea1i th\u00e1p bao g\u1ed3m lo\u1ea1n tr\u01b0\u01a1ng l\u1ef1c c\u01a1 c\u1ea5p, c\u1ee9ng (c\u1ee9ng t\u1eebng c\u01a1n) b\u00e1nh r\u0103ng, c\u01a1n t\u1ed1i m\u1eaft, c\u01a1n ki\u1ec3u \u0111\u1ed9ng kinh, n\u00f3i l\u1eafp b\u1eafp, rung gi\u1eadt nh\u00e3n c\u1ea7u, ti\u1ec3u ti\u1ec7n kh\u00f4ng t\u1ef1 ch\u1ee7, h\u00f4n m\u00ea,&#8230;<\/span><\/p>\n<h3><strong>4.2 T\u00e1c d\u1ee5ng ph\u1ee5 c\u1ee7a Ibuprofen<\/strong><\/h3>\n<p><b><i>Th\u01b0\u1eddng g\u1eb7p:<\/i><\/b><span style=\"font-weight: 400;\"> S\u1ed1t, m\u1ecfi m\u1ec7t, ch\u01b0\u1edbng b\u1ee5ng, bu\u1ed3n n\u00f4n, n\u00f4n, nh\u1ee9c \u0111\u1ea7u, hoa m\u1eaft ch\u1ed1ng m\u1eb7t, m\u1ea9n ng\u1ee9a, ngo\u1ea1i ban. <\/span><\/p>\n<p><b><i>\u00cdt g\u1eb7p:<\/i><\/b><span style=\"font-weight: 400;\"> Ph\u1ea3n \u1ee9ng d\u1ecb \u1ee9ng, vi\u00eam m\u0169i, n\u1ed5i m\u00e0y \u0111ay, \u0111au b\u1ee5ng, ch\u1ea3y m\u00e1u d\u1ea1 d\u00e0y \u2013 ru\u1ed9t, l\u00e0m lo\u00e9t d\u1ea1 d\u00e0y ti\u1ebfn tri\u1ec3n, l\u01a1 m\u01a1, m\u1ea5t ng\u1ee7, \u00f9 tai, r\u1ed1i lo\u1ea1n th\u1ecb gi\u00e1c, th\u00ednh l\u1ef1c gi\u1ea3m, th\u1eddi gian ch\u1ea3y m\u00e1u k\u00e9o d\u00e0i. <\/span><\/p>\n<p><b><i>Hi\u1ebfm g\u1eb7p: <\/i><\/b><span style=\"font-weight: 400;\">Ph\u00f9, n\u1ed5i ban, h\u1ed9i ch\u1ee9ng Stevens \u2013 Johnson, r\u1ee5ng t\u00f3c, h\u1ea1 natri, tr\u1ea7m c\u1ea3m, vi\u00eam m\u00e0ng n\u00e3o v\u00f4 khu\u1ea9n v\u00e0 h\u00f4n m\u00ea, nh\u00ecn m\u1edd, r\u1ed1i lo\u1ea1n m\u00e0u s\u1eafc, gi\u1ea3m th\u1ecb l\u1ef1c do ng\u1ed9 \u0111\u1ed9c thu\u1ed1c, gi\u1ea3m b\u1ea1ch c\u1ea7u, gi\u1ea3m ti\u1ec3u c\u1ea7u, gi\u1ea3m b\u1ea1ch c\u1ea7u trung t\u00ednh, t\u0103ng b\u1ea1ch c\u1ea7u \u01b0a \u00e1i toan, gi\u1ea3m b\u1ea1ch c\u1ea7u h\u1ea1t, thi\u1ebfu m\u00e1u, r\u1ed1i lo\u1ea1n co b\u00f3p t\u00fai m\u1eadt, c\u00e1c th\u1eed nghi\u1ec7m th\u0103m d\u00f2 ch\u1ee9c n\u0103ng gan b\u1ea5t th\u01b0\u1eddng, nhi\u1ec5m \u0111\u1ed9c gan. Vi\u00eam ru\u1ed9t ho\u1ea1i t\u1eed, h\u1ed9i ch\u1ee9ng Crohn, vi\u00eam t\u1ee5y, vi\u00eam b\u00e0ng quang, \u0111\u00e1i ra m\u00e1u, suy th\u1eadn c\u1ea5p, vi\u00eam th\u1eadn k\u1ebd, h\u1ed9i ch\u1ee9ng th\u1eadn h\u01b0, nh\u1ea1y c\u1ea3m v\u1edbi \u00e1nh s\u00e1ng.<\/span><\/p>\n<h3><strong>4.3 T\u00e1c d\u1ee5ng ph\u1ee5 c\u00f3 th\u1ec3 x\u1ea3y ra khi s\u1eed d\u1ee5ng Lithium v\u00e0 Ibuprofen c\u00f9ng nhau<\/strong><\/h3>\n<p>B\u1ec7nh nh\u00e2n c\u00f3 th\u1ec3 g\u1eb7p ph\u1ea3i c\u00e1c d\u1ea5u hi\u1ec7u v\u00e0 tri\u1ec7u ch\u1ee9ng ti\u1ec1m \u1ea9n c\u1ee7a ng\u1ed9 \u0111\u1ed9c Lithium nh\u01b0:<\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Bu\u1ed3n ng\u1ee7<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Ch\u00f3ng m\u1eb7t<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">L\u00fa l\u1eabn<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Y\u1ebfu c\u01a1<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">N\u00f4n\u00a0<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Ti\u00eau ch\u1ea3y<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">U\u1ed1ng nhi\u1ec1u n\u01b0\u1edbc<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Ti\u1ec3u nhi\u1ec1u<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">\u00d9 tai<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">M\u1ea5t c\u00f4ng b\u1eb1ng<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Nh\u00ecn m\u1edd<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Run<\/span><\/li>\n<\/ul>\n<h2><strong>5. C\u1ea3nh b\u00e1o v\u00e0 c\u00e1c bi\u1ec7n ph\u00e1p x\u1eed l\u00fd\u00a0<\/strong><\/h2>\n<p><span style=\"font-weight: 400;\">V\u1edbi kho\u1ea3ng\u00a0 tr\u1ecb li\u1ec7u h\u1eb9p c\u1ee7a Lithium, n\u00ean th\u1eadn tr\u1ecdng khi d\u00f9ng \u0111\u1ed3ng th\u1eddi v\u1edbi NSAID, \u0111\u1eb7c bi\u1ec7t \u1edf ng\u01b0\u1eddi cao tu\u1ed5i ho\u1eb7c b\u1ec7nh nh\u00e2n c\u00f3 c\u00e1c y\u1ebfu t\u1ed1 nguy c\u01a1 kh\u00e1c (v\u00ed d\u1ee5: h\u1ea1n ch\u1ebf Natri, suy th\u1eadn, suy tim sung huy\u1ebft, m\u1ea5t n\u01b0\u1edbc, s\u1eed d\u1ee5ng \u0111\u1ed3ng th\u1eddi thu\u1ed1c l\u1ee3i ti\u1ec3u, thu\u1ed1c \u1ee9c ch\u1ebf men chuy\u1ec3n , ho\u1eb7c thu\u1ed1c \u0111\u1ed1i kh\u00e1ng th\u1ee5 th\u1ec3 angiotensin II).\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">B\u1ec7nh nh\u00e2n n\u00ean ki\u1ec3m tra n\u1ed3ng \u0111\u1ed9 Lithium trong huy\u1ebft thanh c\u1ee9 sau 4 \u0111\u1ebfn 5 ng\u00e0y k\u1ec3 t\u1eeb khi b\u1eaft \u0111\u1ea7u d\u00f9ng NSAID cho \u0111\u1ebfn khi c\u00f3 th\u1ec3 \u0111\u00e1nh gi\u00e1 \u0111\u01b0\u1ee3c m\u1ee9c \u0111\u1ed9 t\u01b0\u01a1ng t\u00e1c ti\u1ec1m t\u00e0ng.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">C\u00f3 th\u1ec3 c\u1ea7n gi\u1ea3m li\u1ec1u Lithium trong m\u1ed9t s\u1ed1 tr\u01b0\u1eddng h\u1ee3p.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Ch\u1ee9c n\u0103ng th\u1eadn c\u0169ng c\u1ea7n \u0111\u01b0\u1ee3c theo d\u00f5i th\u01b0\u1eddng xuy\u00ean.\u00a0<\/span><\/p>\n<h2><strong>\u00a06. K\u1ebft lu\u1eadn<\/strong><\/h2>\n<p><span style=\"font-weight: 400;\">T\u01b0\u01a1ng t\u00e1c gi\u1eefa Lithium v\u00e0 Ibuprofen c\u00f3 th\u1ec3 l\u00e0m t\u0103ng n\u1ed3ng \u0111\u1ed9 Lithium trong m\u00e1u, g\u00e2y ra c\u00e1c t\u00e1c d\u1ee5ng ph\u1ee5 v\u00e0 nguy hi\u1ec3m \u0111\u1ebfn s\u1ee9c kh\u1ecfe c\u1ee7a b\u1ec7nh nh\u00e2n. Vi\u1ec7c gi\u00e1m s\u00e1t v\u00e0 h\u1ea1n ch\u1ebf t\u01b0\u01a1ng t\u00e1c gi\u1eefa hai lo\u1ea1i thu\u1ed1c n\u00e0y l\u00e0 c\u1ef1c k\u1ef3 c\u1ea7n thi\u1ebft \u0111\u1ec3 \u0111\u1ea3m b\u1ea3o an to\u00e0n v\u00e0 hi\u1ec7u qu\u1ea3 trong qu\u00e1 tr\u00ecnh \u0111i\u1ec1u tr\u1ecb.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Ngu\u1ed3n: D\u01b0\u1ee3c th\u01b0 Qu\u1ed1c gia Vi\u1ec7t Nam, Drug.com<\/span><\/p>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Lithium v\u00e0 Ibuprofen l\u00e0 hai lo\u1ea1i thu\u1ed1c th\u01b0\u1eddng \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng trong \u0111i\u1ec1u tr\u1ecb c\u00e1c b\u1ec7nh l\u00fd kh\u00e1c nhau. Tuy nhi\u00ean, khi s\u1eed d\u1ee5ng \u0111\u1ed3ng th\u1eddi, ch\u00fang c\u00f3 th\u1ec3 t\u01b0\u01a1ng t\u00e1c g\u00e2y t\u0103ng \u0111\u00e1ng k\u1ec3 n\u1ed3ng \u0111\u1ed9 Lithium trong huy\u1ebft thanh, d\u1eabn \u0111\u1ebfn c\u00e1c t\u00e1c d\u1ee5ng ph\u1ee5 nghi\u00eam tr\u1ecdng. \u0110\u1eb7c bi\u1ec7t, ng\u01b0\u1eddi cao tu\u1ed5i v\u00e0 [&hellip;]<\/p>\n","protected":false},"author":53,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[12],"tags":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v20.4 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>T\u01b0\u01a1ng t\u00e1c thu\u1ed1c gi\u1eefa Lithium v\u00e0 Ibuprofen - Vinmec<\/title>\n<meta name=\"description\" content=\"Lithium v\u00e0 Ibuprofen l\u00e0 hai lo\u1ea1i thu\u1ed1c th\u01b0\u1eddng \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng trong \u0111i\u1ec1u tr\u1ecb c\u00e1c b\u1ec7nh l\u00fd kh\u00e1c nhau. 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