{"id":23781,"date":"2023-04-18T00:00:45","date_gmt":"2023-04-17T17:00:45","guid":{"rendered":"http:\/\/noithathoaphat.in\/ctv\/?p=23781"},"modified":"2023-04-18T10:58:05","modified_gmt":"2023-04-18T03:58:05","slug":"bach-cau-man-dong-tuy-chan-doan-va-dieu-tri","status":"publish","type":"post","link":"http:\/\/noithathoaphat.in\/ctv\/index.php\/2023\/04\/18\/bach-cau-man-dong-tuy-chan-doan-va-dieu-tri\/","title":{"rendered":"B\u1ea1ch c\u1ea7u m\u1ea1n d\u00f2ng t\u1ee7y: ch\u1ea9n \u0111o\u00e1n v\u00e0 \u0111i\u1ec1u tr\u1ecb"},"content":{"rendered":"<p><strong>B\u1ea1ch c\u1ea7u m\u1ea1n d\u00f2ng t\u1ee7y (Chronic myeloic leukemia &#8211; CML) l\u00e0 m\u1ed9t lo\u1ea1i ung th\u01b0 m\u00e1u hi\u1ebfm g\u1eb7p. B\u1ec7nh xu\u1ea5t hi\u1ec7n khi c\u00e1c t\u1ebf b\u00e0o b\u1ea1ch c\u1ea7u d\u00f2ng t\u1ee7y ph\u00e1t tri\u1ec3n kh\u00f4ng ki\u1ec3m so\u00e1t. B\u1ec7nh CML th\u01b0\u1eddng \u0111\u01b0\u1ee3c ch\u1ea9n \u0111o\u00e1n \u1edf ng\u01b0\u1eddi tr\u01b0\u1edfng th\u00e0nh, v\u1edbi \u0111\u1ed9 tu\u1ed5i trung b\u00ecnh t\u1eeb 50 \u0111\u1ebfn 60 tu\u1ed5i, nh\u01b0ng c\u0169ng c\u00f3 th\u1ec3 xu\u1ea5t hi\u1ec7n \u1edf tr\u1ebb em.<\/strong><\/p>\n<h2>1. Gi\u1edbi thi\u1ec7u<\/h2>\n<p>B\u1ea1ch c\u1ea7u m\u1ea1n d\u00f2ng t\u1ee7y (Chronic myeloic leukemia &#8211; CML) l\u00e0 m\u1ed9t lo\u1ea1i ung th\u01b0 m\u00e1u hi\u1ebfm g\u1eb7p, xu\u1ea5t hi\u1ec7n khi c\u00e1c t\u1ebf b\u00e0o b\u1ea1ch c\u1ea7u d\u00f2ng t\u1ee7y ph\u00e1t tri\u1ec3n kh\u00f4ng ki\u1ec3m so\u00e1t. B\u1ec7nh CML \u0111\u01b0\u1ee3c x\u00e1c \u0111\u1ecbnh b\u1edfi m\u1ed9t \u0111\u1eb7c tr\u01b0ng di truy\u1ec1n g\u1ecdi l\u00e0 gen Philadelphia (Ph) \u2013 k\u1ebft qu\u1ea3 c\u1ee7a s\u1ef1 chuy\u1ec3n \u0111o\u1ea1n gi\u1eefa nhi\u1ec5m s\u1eafc th\u1ec3 s\u1ed1 9 v\u00e0 nhi\u1ec5m s\u1eafc th\u1ec3 s\u1ed1 22, t (9; 22). Gen n\u00e0y g\u00e2y ra m\u1ed9t s\u1ef1 thay \u0111\u1ed5i trong qu\u00e1 tr\u00ecnh t\u0103ng tr\u01b0\u1edfng c\u1ee7a t\u1ebf b\u00e0o b\u1ea1ch c\u1ea7u d\u00f2ng t\u1ee7y, d\u1eabn \u0111\u1ebfn s\u1ef1 ph\u00e1t tri\u1ec3n kh\u00f4ng ki\u1ec3m so\u00e1t c\u1ee7a c\u00e1c t\u1ebf b\u00e0o n\u00e0y.<\/p>\n<figure id=\"attachment_23791\" aria-describedby=\"caption-attachment-23791\" style=\"width: 300px\" class=\"wp-caption aligncenter\"><img decoding=\"async\" loading=\"lazy\" class=\"size-medium wp-image-23791\" src=\"http:\/\/noithathoaphat.in\/ctv\/wp-content\/uploads\/2023\/04\/phil-300x170.png\" alt=\"chuyen-doan-nhiem-sac-the-9-va-22-trong-CML\" width=\"300\" height=\"170\" srcset=\"http:\/\/noithathoaphat.in\/ctv\/wp-content\/uploads\/2023\/04\/phil-300x170.png 300w, http:\/\/noithathoaphat.in\/ctv\/wp-content\/uploads\/2023\/04\/phil.png 632w\" sizes=\"(max-width: 300px) 100vw, 300px\" \/><figcaption id=\"caption-attachment-23791\" class=\"wp-caption-text\">Chuy\u1ec3n \u0111o\u1ea1n nhi\u1ec5m s\u1eafc th\u1ec3 s\u1ed1 9 v\u00e0 22 trong CML<\/figcaption><\/figure>\n<h2>2. Tri\u1ec7u ch\u1ee9ng <a href=\"https:\/\/www.vinmec.com\/vi\/tin-tuc\/thong-tin-suc-khoe\/suc-khoe-tong-quat\/benh-bach-cau-man-dong-tuy-chan-doan-va-dieu-tri\/\">b\u1ec7nh b\u1ea1ch c\u1ea7u m\u1ea1n d\u00f2ng t\u1ee7y<\/a><\/h2>\n<p>C\u00e1c tri\u1ec7u ch\u1ee9ng c\u1ee7a b\u1ec7nh CML bao g\u1ed3m m\u1ec7t m\u1ecfi, s\u1ed1t, \u0111au \u0111\u1ea7u, \u0111au x\u01b0\u01a1ng v\u00e0 kh\u00f3 th\u1edf. Tuy nhi\u00ean, \u1edf m\u1ed9t s\u1ed1 tr\u01b0\u1eddng h\u1ee3p, b\u1ec7nh c\u00f3 th\u1ec3 kh\u00f4ng g\u00e2y ra tri\u1ec7u ch\u1ee9ng r\u00f5 r\u00e0ng v\u00e0 \u0111\u01b0\u1ee3c ph\u00e1t hi\u1ec7n trong c\u00e1c x\u00e9t nghi\u1ec7m m\u00e1u th\u01b0\u1eddng k\u1ef3. C\u00e1c tri\u1ec7u ch\u1ee9ng n\u00e0y ph\u00e1t tri\u1ec3n ch\u1eadm v\u00e0 b\u1ec7nh CML th\u01b0\u1eddng \u0111\u01b0\u1ee3c chia th\u00e0nh ba giai \u0111o\u1ea1n kh\u00e1c nhau: giai \u0111o\u1ea1n 1, giai \u0111o\u1ea1n 2 v\u00e0 giai \u0111o\u1ea1n 3.<\/p>\n<h3>2.1. Giai \u0111o\u1ea1n 1<\/h3>\n<p>B\u1ec7nh CML th\u01b0\u1eddng kh\u00f4ng c\u00f3 tri\u1ec7u ch\u1ee9ng \u0111\u00e1ng k\u1ec3, v\u00e0 c\u00e1c t\u1ebf b\u00e0o ung th\u01b0 th\u01b0\u1eddng ch\u1ec9 \u0111\u01b0\u1ee3c ph\u00e1t hi\u1ec7n trong c\u00e1c x\u00e9t nghi\u1ec7m m\u00e1u th\u01b0\u1eddng k\u1ef3.<\/p>\n<h3>2.2. Giai \u0111o\u1ea1n 2<\/h3>\n<p>Th\u01b0\u1eddng \u0111\u01b0\u1ee3c x\u00e1c \u0111\u1ecbnh khi c\u00e1c tri\u1ec7u ch\u1ee9ng nh\u01b0 s\u1ed1t, m\u1ec7t m\u1ecfi v\u00e0 \u0111au x\u01b0\u01a1ng b\u1eaft \u0111\u1ea7u xu\u1ea5t hi\u1ec7n.<\/p>\n<h3>2.3. Giai \u0111o\u1ea1n 3<\/h3>\n<p>\u0110\u00e2y l\u00e0 giai \u0111o\u1ea1n cu\u1ed1i c\u00f9ng v\u00e0 nghi\u00eam tr\u1ecdng nh\u1ea5t, v\u1edbi c\u00e1c tri\u1ec7u ch\u1ee9ng nh\u01b0 s\u1ed1t cao, gi\u1ea3m c\u00e2n, ch\u1ea5t l\u01b0\u1ee3ng cu\u1ed9c s\u1ed1ng ng\u01b0\u1eddi b\u1ec7nh gi\u1ea3m tr\u1ea7m trong.<\/p>\n<h2>3. Ch\u1ea9n \u0111o\u00e1n b\u1ec7nh b\u1ea1ch c\u1ea7u m\u1ea1n d\u00f2ng t\u1ee7y<\/h2>\n<p>Ch\u1ea9n \u0111o\u00e1n b\u1ea1ch c\u1ea7u m\u1ea1n d\u00f2ng t\u1ee7y (CML) \u0111\u00f2i h\u1ecfi s\u1ef1 k\u1ebft h\u1ee3p gi\u1eefa c\u00e1c d\u1ea5u hi\u1ec7u l\u00e2m s\u00e0ng, k\u1ebft qu\u1ea3 x\u00e9t nghi\u1ec7m m\u00e1u v\u00e0 t\u1ee7y x\u01b0\u01a1ng, c\u00f9ng v\u1edbi vi\u1ec7c x\u00e1c \u0111\u1ecbnh s\u1ef1 c\u00f3 m\u1eb7t c\u1ee7a gen Philadelphia.<\/p>\n<p>C\u00e1c d\u1ea5u hi\u1ec7u l\u00e2m s\u00e0ng c\u1ee7a b\u1ec7nh CML bao g\u1ed3m m\u1ec7t m\u1ecfi, s\u1ed1t, \u0111au \u0111\u1ea7u, \u0111au x\u01b0\u01a1ng v\u00e0 kh\u00f3 th\u1edf. Tuy nhi\u00ean, c\u00e1c tri\u1ec7u ch\u1ee9ng n\u00e0y kh\u00f4ng \u0111\u1eb7c hi\u1ec7u v\u00e0 c\u00f3 th\u1ec3 xu\u1ea5t hi\u1ec7n \u1edf m\u1ed9t s\u1ed1 b\u1ec7nh nh\u00e2n v\u1edbi c\u00e1c b\u1ec7nh kh\u00e1c.<\/p>\n<p>Vi\u1ec7c s\u1eed d\u1ee5ng x\u00e9t nghi\u1ec7m m\u00e1u \u0111\u00f3ng vai tr\u00f2 quan tr\u1ecdng trong vi\u1ec7c ch\u1ea9n \u0111o\u00e1n b\u1ec7nh CML. X\u00e9t nghi\u1ec7m m\u00e1u th\u01b0\u1eddng cho th\u1ea5y s\u1ef1 t\u0103ng s\u1ed1 l\u01b0\u1ee3ng t\u1ebf b\u00e0o b\u1ea1ch c\u1ea7u v\u00e0 s\u1ed1 l\u01b0\u1ee3ng t\u1ebf b\u00e0o d\u1ea1ng m\u1ea1n trong m\u00e1u. Ngo\u00e0i ra, c\u00e1c x\u00e9t nghi\u1ec7m m\u00e1u kh\u00e1c nh\u01b0 x\u00e9t nghi\u1ec7m protein, x\u00e9t nghi\u1ec7m enzyme v\u00e0 x\u00e9t nghi\u1ec7m mi\u1ec5n d\u1ecbch c\u0169ng c\u00f3 th\u1ec3 \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng \u0111\u1ec3 x\u00e1c \u0111\u1ecbnh s\u1ef1 c\u00f3 m\u1eb7t c\u1ee7a gen Philadelphia.<\/p>\n<p>Vi\u1ec7c x\u00e9t nghi\u1ec7m t\u1ee7y x\u01b0\u01a1ng l\u00e0 b\u01b0\u1edbc ti\u1ebfp theo quan tr\u1ecdng \u0111\u1ec3 x\u00e1c \u0111\u1ecbnh ch\u1ea9n \u0111o\u00e1n b\u1ec7nh CML. X\u00e9t nghi\u1ec7m t\u1ee7y x\u01b0\u01a1ng cho th\u1ea5y s\u1ef1 t\u0103ng s\u1ed1 l\u01b0\u1ee3ng t\u1ebf b\u00e0o b\u1ea1ch c\u1ea7u d\u1ea1ng m\u1ea1n trong t\u1ee7y x\u01b0\u01a1ng. S\u1ef1 c\u00f3 m\u1eb7t c\u1ee7a gen Philadelphia c\u0169ng c\u00f3 th\u1ec3 \u0111\u01b0\u1ee3c x\u00e1c \u0111\u1ecbnh trong t\u1ee7y x\u01b0\u01a1ng.<\/p>\n<p>Ngo\u00e0i vi\u1ec7c x\u00e9t nghi\u1ec7m m\u00e1u v\u00e0 t\u1ee7y x\u01b0\u01a1ng, vi\u1ec7c s\u1eed d\u1ee5ng c\u00e1c k\u1ef9 thu\u1eadt h\u00ecnh \u1ea3nh nh\u01b0 ch\u1ee5p X-quang, si\u00eau \u00e2m ho\u1eb7c CT scan c\u00f3 th\u1ec3 \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng \u0111\u1ec3 x\u00e1c \u0111\u1ecbnh s\u1ef1 lan r\u1ed9ng c\u1ee7a b\u1ec7nh v\u00e0 \u0111\u00e1nh gi\u00e1 t\u00ecnh tr\u1ea1ng c\u1ee7a c\u00e1c c\u01a1 quan kh\u00e1c trong c\u01a1 th\u1ec3.<\/p>\n<p>T\u00f3m l\u1ea1i, vi\u1ec7c ch\u1ea9n \u0111o\u00e1n b\u1ea1ch c\u1ea7u m\u1ea1n d\u00f2ng t\u1ee7y \u0111\u00f2i h\u1ecfi s\u1ef1 k\u1ebft h\u1ee3p gi\u1eefa c\u00e1c d\u1ea5u hi\u1ec7u l\u00e2m s\u00e0ng, k\u1ebft qu\u1ea3 x\u00e9t nghi\u1ec7m m\u00e1u v\u00e0 t\u1ee7y x\u01b0\u01a1ng, c\u00f9ng v\u1edbi vi\u1ec7c x\u00e1c \u0111\u1ecbnh s\u1ef1 c\u00f3 m\u1eb7t c\u1ee7a gen Philadelphia. Vi\u1ec7c s\u1eed d\u1ee5ng c\u00e1c k\u1ef9 thu\u1eadt h\u00ecnh \u1ea3nh c\u0169ng c\u00f3 th\u1ec3 \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng \u0111\u1ec3 \u0111\u00e1nh gi\u00e1 t\u00ecnh tr\u1ea1ng c\u1ee7a b\u1ec7nh v\u00e0 \u0111\u00e1nh gi\u00e1 s\u1ef1 lan r\u1ed9ng c\u1ee7a b\u1ec7nh.<\/p>\n<h2>4. \u0110i\u1ec1u tr\u1ecb b\u1ec7nh b\u1ea1ch c\u1ea7u m\u1ea1n d\u00f2ng t\u1ee7y<\/h2>\n<p>\u0110i\u1ec1u tr\u1ecb b\u1ec7nh b\u1ea1ch c\u1ea7u m\u1ea1n d\u00f2ng t\u1ee7y (CML) ph\u1ee5 thu\u1ed9c v\u00e0o giai \u0111o\u1ea1n c\u1ee7a b\u1ec7nh, s\u1ee9c kh\u1ecfe t\u1ed5ng th\u1ec3 c\u1ee7a b\u1ec7nh nh\u00e2n v\u00e0 k\u1ebft qu\u1ea3 x\u00e9t nghi\u1ec7m. Hi\u1ec7n nay, c\u00e1c lo\u1ea1i thu\u1ed1c \u0111\u01b0\u1ee3c g\u1ecdi l\u00e0 tyrosine kinase inhibitors (TKIs) l\u00e0 ph\u01b0\u01a1ng ph\u00e1p \u0111i\u1ec1u tr\u1ecb ch\u00ednh cho b\u1ec7nh CML, nh\u1eb1m ng\u0103n ch\u1eb7n s\u1ef1 ph\u00e1t tri\u1ec3n c\u1ee7a c\u00e1c t\u1ebf b\u00e0o ung th\u01b0.<\/p>\n<p>C\u00e1c thu\u1ed1c TKIs nh\u01b0 imatinib, dasatinib v\u00e0 nilotinib c\u00f3 kh\u1ea3 n\u0103ng \u1ee9c ch\u1ebf ho\u1ea1t \u0111\u1ed9ng c\u1ee7a protein tyrosine kinase trong c\u00e1c t\u1ebf b\u00e0o ung th\u01b0, l\u00e0m gi\u1ea3m s\u1ef1 ph\u00e1t tri\u1ec3n c\u1ee7a c\u00e1c t\u1ebf b\u00e0o n\u00e0y. Tuy nhi\u00ean, \u1edf m\u1ed9t s\u1ed1 b\u1ec7nh nh\u00e2n, s\u1ef1 \u0111\u00e1p \u1ee9ng v\u1edbi c\u00e1c thu\u1ed1c TKIs c\u00f3 th\u1ec3 kh\u00f4ng t\u1ed1t ho\u1eb7c c\u00f3 th\u1ec3 ph\u00e1t tri\u1ec3n kh\u00e1ng thu\u1ed1c sau m\u1ed9t th\u1eddi gian s\u1eed d\u1ee5ng.<\/p>\n<p>Ngo\u00e0i ra, c\u00e1c ph\u01b0\u01a1ng ph\u00e1p \u0111i\u1ec1u tr\u1ecb kh\u00e1c nh\u01b0 t\u1ee7y x\u01b0\u01a1ng gh\u00e9p c\u0169ng c\u00f3 th\u1ec3 \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng \u0111\u1ed1i v\u1edbi m\u1ed9t s\u1ed1 b\u1ec7nh nh\u00e2n, \u0111\u1eb7c bi\u1ec7t l\u00e0 \u1edf nh\u1eefng tr\u01b0\u1eddng h\u1ee3p kh\u00f4ng \u0111\u00e1p \u1ee9ng v\u1edbi c\u00e1c thu\u1ed1c TKIs ho\u1eb7c c\u00f3 d\u1ea5u hi\u1ec7u b\u1ec7nh t\u00e1i ph\u00e1t.<\/p>\n<p>Tuy nhi\u00ean, c\u00e1c ph\u01b0\u01a1ng ph\u00e1p \u0111i\u1ec1u tr\u1ecb n\u00e0y c\u0169ng c\u00f3 nh\u1eefng r\u1ee7i ro v\u00e0 t\u00e1c d\u1ee5ng ph\u1ee5 nh\u1ea5t \u0111\u1ecbnh. Vi\u1ec7c s\u1eed d\u1ee5ng c\u00e1c thu\u1ed1c TKIs c\u00f3 th\u1ec3 g\u00e2y ra c\u00e1c t\u00e1c d\u1ee5ng ph\u1ee5 nh\u01b0 m\u1ec7t m\u1ecfi, bu\u1ed3n n\u00f4n, \u0111au \u0111\u1ea7u, t\u0103ng c\u00e2n v\u00e0 gi\u1ea3m huy\u1ebft \u00e1p. C\u00e1c ph\u01b0\u01a1ng ph\u00e1p \u0111i\u1ec1u tr\u1ecb kh\u00e1c nh\u01b0 t\u1ee7y x\u01b0\u01a1ng gh\u00e9p c\u0169ng c\u00f3 th\u1ec3 g\u00e2y ra c\u00e1c t\u00e1c d\u1ee5ng ph\u1ee5 nh\u01b0 nhi\u1ec5m tr\u00f9ng, ph\u1ea3n \u1ee9ng gh\u00e9p t\u1ee7y x\u01b0\u01a1ng v\u00e0 c\u00e1c v\u1ea5n \u0111\u1ec1 v\u1ec1 h\u1ec7 th\u1ed1ng mi\u1ec5n d\u1ecbch.<\/p>\n<p>T\u00f3m l\u1ea1i, \u0111i\u1ec1u tr\u1ecb b\u1ec7nh b\u1ea1ch c\u1ea7u m\u1ea1n d\u00f2ng t\u1ee7y \u0111\u00f2i h\u1ecfi s\u1ef1 \u0111a d\u1ea1ng trong c\u00e1c ph\u01b0\u01a1ng ph\u00e1p \u0111i\u1ec1u tr\u1ecb \u0111\u1ec3 \u0111\u00e1p \u1ee9ng v\u1edbi t\u1eebng tr\u01b0\u1eddng h\u1ee3p c\u1ee5 th\u1ec3. C\u00e1c thu\u1ed1c TKIs l\u00e0 ph\u01b0\u01a1ng ph\u00e1p \u0111i\u1ec1u tr\u1ecb ch\u00ednh cho b\u1ec7nh CML, tuy nhi\u00ean, c\u00e1c ph\u01b0\u01a1ng ph\u00e1p \u0111i\u1ec1u tr\u1ecb kh\u00e1c nh\u01b0 t\u1ee7y x\u01b0\u01a1ng gh\u00e9p c\u0169ng c\u00f3 th\u1ec3 \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng. Vi\u1ec7c \u0111\u00e1nh gi\u00e1 v\u00e0 qu\u1ea3n l\u00fd c\u00e1c t\u00e1c d\u1ee5ng ph\u1ee5 c\u1ee7a c\u00e1c ph\u01b0\u01a1ng ph\u00e1p \u0111i\u1ec1u tr\u1ecb l\u00e0 r\u1ea5t quan tr\u1ecdng \u0111\u1ec3 \u0111\u1ea3m b\u1ea3o hi\u1ec7u qu\u1ea3 v\u00e0 an to\u00e0n cho b\u1ec7nh nh\u00e2n.<\/p>\n<h2>5. K\u1ebft lu\u1eadn<\/h2>\n<p>B\u1ec7nh CML l\u00e0 m\u1ed9t b\u1ec7nh ung th\u01b0 m\u00e1u c\u00f3 t\u00ednh ch\u1ea5t \u0111\u1eb7c bi\u1ec7t v\u00e0 c\u1ea7n \u0111\u01b0\u1ee3c ch\u1ea9n \u0111o\u00e1n v\u00e0 \u0111i\u1ec1u tr\u1ecb k\u1ef9 l\u01b0\u1ee1ng. C\u00e1c thu\u1ed1c TKIs \u0111\u00e3 mang l\u1ea1i s\u1ef1 ti\u1ebfn b\u1ed9 \u0111\u00e1ng k\u1ec3 trong \u0111i\u1ec1u tr\u1ecb b\u1ec7nh CML v\u00e0 \u0111ang \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng r\u1ed9ng r\u00e3i tr\u00ean to\u00e0n th\u1ebf gi\u1edbi.\u00a0Tuy nhi\u00ean, vi\u1ec7c nghi\u00ean c\u1ee9u v\u00e0 ph\u00e1t tri\u1ec3n c\u00e1c ph\u01b0\u01a1ng ph\u00e1p \u0111i\u1ec1u tr\u1ecb m\u1edbi v\u1eabn l\u00e0 m\u1ed9t th\u00e1ch th\u1ee9c l\u1edbn trong vi\u1ec7c ki\u1ec3m so\u00e1t v\u00e0 \u0111i\u1ec1u tr\u1ecb b\u1ec7nh CML.<\/p>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>B\u1ea1ch c\u1ea7u m\u1ea1n d\u00f2ng t\u1ee7y (Chronic myeloic leukemia &#8211; CML) l\u00e0 m\u1ed9t lo\u1ea1i ung th\u01b0 m\u00e1u hi\u1ebfm g\u1eb7p. B\u1ec7nh xu\u1ea5t hi\u1ec7n khi c\u00e1c t\u1ebf b\u00e0o b\u1ea1ch c\u1ea7u d\u00f2ng t\u1ee7y ph\u00e1t tri\u1ec3n kh\u00f4ng ki\u1ec3m so\u00e1t. 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