{"id":23690,"date":"2023-04-22T23:14:59","date_gmt":"2023-04-22T16:14:59","guid":{"rendered":"http:\/\/noithathoaphat.in\/ctv\/?p=23690"},"modified":"2023-04-22T23:14:59","modified_gmt":"2023-04-22T16:14:59","slug":"tuong-tac-thuoc-giua-methotrexate-ibuprofen","status":"publish","type":"post","link":"http:\/\/noithathoaphat.in\/ctv\/index.php\/2023\/04\/22\/tuong-tac-thuoc-giua-methotrexate-ibuprofen\/","title":{"rendered":"Methotrexate v\u00e0 Ibuprofen: C\u01a1 ch\u1ebf, ch\u1ec9 \u0111\u1ecbnh, t\u01b0\u01a1ng t\u00e1c thu\u1ed1c"},"content":{"rendered":"<h2><b>Methotrexate v\u00e0 Ibuprofen l\u00e0 hai lo\u1ea1i thu\u1ed1c th\u01b0\u1eddng \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng \u0111\u1ec3 \u0111i\u1ec1u tr\u1ecb c\u00e1c b\u1ec7nh li\u00ean quan \u0111\u1ebfn vi\u00eam v\u00e0 \u0111au. Khi s\u1eed d\u1ee5ng c\u00f9ng l\u00fac, t\u01b0\u01a1ng t\u00e1c gi\u1eefa hai lo\u1ea1i thu\u1ed1c n\u00e0y c\u00f3 th\u1ec3 \u1ea3nh h\u01b0\u1edfng \u0111\u1ebfn hi\u1ec7u qu\u1ea3 \u0111i\u1ec1u tr\u1ecb, g\u00e2y ra c\u00e1c t\u00e1c d\u1ee5ng ph\u1ee5 v\u00e0 th\u1eadm ch\u00ed c\u00f3 th\u1ec3 g\u00e2y nguy hi\u1ec3m \u0111\u1ebfn s\u1ee9c kh\u1ecfe c\u1ee7a b\u1ec7nh nh\u00e2n. Do \u0111\u00f3, vi\u1ec7c t\u0103ng c\u01b0\u1eddng gi\u00e1m s\u00e1t v\u00e0 h\u1ea1n ch\u1ebf t\u01b0\u01a1ng t\u00e1c gi\u1eefa hai lo\u1ea1i thu\u1ed1c n\u00e0y l\u00e0 c\u1ef1c k\u1ef3 quan tr\u1ecdng trong qu\u00e1 tr\u00ecnh \u0111i\u1ec1u tr\u1ecb.<\/b><\/h2>\n<h2><strong>1. Th\u00f4ng tin chung v\u1ec1 Methotrexate v\u00e0 Ibuprofen<\/strong><\/h2>\n<h3><strong>1.1. Methotrexate<\/strong><\/h3>\n<p><span style=\"font-weight: 400;\">D\u01b0\u1ee3c l\u00fd v\u00e0 c\u01a1 ch\u1ebf t\u00e1c d\u1ee5ng:\u00a0<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Methotrexate l\u00e0 ch\u1ea5t kh\u00e1ng acid folic c\u00f3 t\u00e1c d\u1ee5ng ch\u1ed1ng ung th\u01b0. Do c\u00f3 \u00e1i l\u1ef1c v\u1edbi enzym dihydrofolat reductase m\u1ea1nh h\u01a1n acid folic n\u1ed9i sinh, thu\u1ed1c \u1ee9c ch\u1ebf acid folic chuy\u1ec3n th\u00e0nh acid tetrahydrofolic \u2013 ch\u1ea5t c\u1ea7n thi\u1ebft trong t\u1ed5ng h\u1ee3p purin v\u00e0 pyrimidin \u2013 d\u1eabn t\u1edbi \u1ee9c ch\u1ebf sinh t\u1ed5ng h\u1ee3p ADN v\u00e0 ARN v\u00e0 l\u00e0m ng\u1eebng qu\u00e1 tr\u00ecnh gi\u00e1n ph\u00e2n, do v\u1eady Methotrexate \u1ee9c ch\u1ebf \u0111\u1eb7c hi\u1ec7u pha S c\u1ee7a chu k\u1ef3 t\u1ebf b\u00e0o. C\u00e1c m\u00f4 t\u0103ng sinh m\u1ea1nh nh\u01b0 c\u00e1c t\u1ebf b\u00e0o ung th\u01b0 ph\u00e2n chia nhanh, t\u1ee7y x\u01b0\u01a1ng, t\u1ebf b\u00e0o thai nhi, bi\u1ec3u m\u00f4 da (b\u1ec7nh v\u1ea3y n\u1ebfn), ni\u00eam m\u1ea1c \u0111\u01b0\u1eddng ti\u00eau h\u00f3a l\u00e0 nh\u1eefng t\u1ebf b\u00e0o nh\u1ea1y c\u1ea3m nh\u1ea5t v\u1edbi Methotrexate.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Methotrexate c\u00f3 t\u00e1c d\u1ee5ng \u1ee9c ch\u1ebf mi\u1ec5n d\u1ecbch, \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng trong \u0111i\u1ec1u tr\u1ecb vi\u00eam kh\u1edbp d\u1ea1ng th\u1ea5p. C\u01a1 ch\u1ebf ch\u1eefa vi\u00eam kh\u1edbp d\u1ea1ng th\u1ea5p g\u1ed3m t\u00e1c d\u1ee5ng \u1ee9c ch\u1ebf mi\u1ec5n d\u1ecbch v\u00e0\/ho\u1eb7c t\u00e1c d\u1ee5ng ch\u1ed1ng vi\u00eam. T\u00e1c d\u1ee5ng \u1ee9c ch\u1ebf mi\u1ec5n d\u1ecbch c\u0169ng \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng \u0111\u1ec3 ng\u0103n ch\u1eb7n ph\u1ea3n \u1ee9ng ch\u1ed1ng l\u1ea1i m\u1ea3nh gh\u00e9p c\u1ee7a v\u1eadt ch\u1ee7 sau gh\u00e9p t\u1ee7y x\u01b0\u01a1ng.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Kh\u00e1ng Methotrexate c\u00f3 th\u1ec3 x\u1ea3y ra v\u00e0 li\u00ean quan \u0111\u1ebfn s\u1ef1 gi\u1ea3m thu nh\u1eadn thu\u1ed1c c\u1ee7a t\u1ebf b\u00e0o, t\u0103ng ho\u1ea1t t\u00ednh c\u1ee7a dihydrofolat reductase (li\u00ean quan v\u1edbi t\u0103ng t\u1ed5ng h\u1ee3p enzym), ho\u1eb7c gi\u1ea3m g\u1eafn Methotrexate v\u1edbi dihydrofolat reductase (do protein dihydrofolat reductase \u0111\u1ed9t bi\u1ebfn) v\u00e0 gi\u1ea3m n\u1ed3ng \u0111\u1ed9 c\u00e1c ch\u1ea5t chuy\u1ec3n h\u00f3a polyglutamylat c\u1ee7a thu\u1ed1c trong t\u1ebf b\u00e0o.<\/span><\/li>\n<\/ul>\n<figure id=\"attachment_23717\" aria-describedby=\"caption-attachment-23717\" style=\"width: 300px\" class=\"wp-caption aligncenter\"><img decoding=\"async\" loading=\"lazy\" class=\"size-medium wp-image-23717\" src=\"http:\/\/noithathoaphat.in\/ctv\/wp-content\/uploads\/2023\/04\/Methotrexate-1-300x300.jpg\" alt=\"Methotrexate\" width=\"300\" height=\"300\" srcset=\"http:\/\/noithathoaphat.in\/ctv\/wp-content\/uploads\/2023\/04\/Methotrexate-1-300x300.jpg 300w, http:\/\/noithathoaphat.in\/ctv\/wp-content\/uploads\/2023\/04\/Methotrexate-1-150x150.jpg 150w, http:\/\/noithathoaphat.in\/ctv\/wp-content\/uploads\/2023\/04\/Methotrexate-1.jpg 720w\" sizes=\"(max-width: 300px) 100vw, 300px\" \/><figcaption id=\"caption-attachment-23717\" class=\"wp-caption-text\">Methotrexate<\/figcaption><\/figure>\n<h3><strong>1.2. <a href=\"https:\/\/www.vinmec.com\/vi\/thuoc\/ibuprofen-99\/\">Ibuprofen<\/a><\/strong><\/h3>\n<p><span style=\"font-weight: 400;\">D\u01b0\u1ee3c l\u00fd v\u00e0 c\u01a1 ch\u1ebf t\u00e1c d\u1ee5ng:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Ibuprofen l\u00e0 thu\u1ed1c ch\u1ed1ng vi\u00eam kh\u00f4ng steroid (NSAID), d\u1eabn xu\u1ea5t t\u1eeb acid propionic. T\u01b0\u01a1ng t\u1ef1 nh\u01b0 c\u00e1c thu\u1ed1c ch\u1ed1ng vi\u00eam kh\u00f4ng steroid kh\u00e1c, Ibuprofen c\u00f3 t\u00e1c d\u1ee5ng gi\u1ea3m \u0111au, h\u1ea1 s\u1ed1t v\u00e0 ch\u1ed1ng vi\u00eam. C\u01a1 ch\u1ebf t\u00e1c d\u1ee5ng c\u1ee7a thu\u1ed1c l\u00e0 \u1ee9c ch\u1ebf enzym prostaglandin synthetase v\u00e0 do \u0111\u00f3 ng\u0103n t\u1ea1o ra prostaglandin, thromboxan v\u00e0 c\u00e1c s\u1ea3n ph\u1ea9m kh\u00e1c c\u1ee7a enzym cyclooxygenase. Ibuprofen c\u0169ng \u1ee9c ch\u1ebf t\u1ed5ng h\u1ee3p prostacyclin \u1edf th\u1eadn v\u00e0 c\u00f3 th\u1ec3 g\u00e2y nguy c\u01a1 \u1ee9 n\u01b0\u1edbc do l\u00e0m gi\u1ea3m d\u00f2ng m\u00e1u t\u1edbi th\u1eadn. C\u1ea7n ph\u1ea3i l\u01b0u \u00fd \u0111\u1ebfn \u0111i\u1ec1u n\u00e0y khi ch\u1ec9 \u0111\u1ecbnh cho ng\u01b0\u1eddi b\u1ec7nh c\u00f3 suy th\u1eadn, suy tim, suy gan v\u00e0 c\u00e1c b\u1ec7nh c\u00f3 r\u1ed1i lo\u1ea1n v\u1ec1 th\u1ec3 t\u00edch huy\u1ebft t\u01b0\u01a1ng.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">T\u00e1c d\u1ee5ng ch\u1ed1ng vi\u00eam c\u1ee7a Ibuprofen xu\u1ea5t hi\u1ec7n sau hai ng\u00e0y \u0111i\u1ec1u tr\u1ecb. Ibuprofen c\u00f3 t\u00e1c d\u1ee5ng h\u1ea1 s\u1ed1t m\u1ea1nh h\u01a1n Aspirin, nh\u01b0ng k\u00e9m Indomethacin. Thu\u1ed1c c\u00f3 t\u00e1c d\u1ee5ng ch\u1ed1ng vi\u00eam t\u1ed1t v\u00e0 c\u00f3 t\u00e1c d\u1ee5ng gi\u1ea3m \u0111au t\u1ed1t trong \u0111i\u1ec1u tr\u1ecb vi\u00eam kh\u1edbp d\u1ea1ng th\u1ea5p thanh thi\u1ebfu ni\u00ean.<\/span><\/li>\n<\/ul>\n<figure id=\"attachment_23719\" aria-describedby=\"caption-attachment-23719\" style=\"width: 300px\" class=\"wp-caption aligncenter\"><img decoding=\"async\" loading=\"lazy\" class=\"size-medium wp-image-23719\" src=\"http:\/\/noithathoaphat.in\/ctv\/wp-content\/uploads\/2023\/04\/Ibuprofen-300x200.jpg\" alt=\"Ibuprofen\" width=\"300\" height=\"200\" srcset=\"http:\/\/noithathoaphat.in\/ctv\/wp-content\/uploads\/2023\/04\/Ibuprofen-300x200.jpg 300w, http:\/\/noithathoaphat.in\/ctv\/wp-content\/uploads\/2023\/04\/Ibuprofen.jpg 768w\" sizes=\"(max-width: 300px) 100vw, 300px\" \/><figcaption id=\"caption-attachment-23719\" class=\"wp-caption-text\">Ibuprofen<\/figcaption><\/figure>\n<h2><strong>2. Ch\u1ec9 \u0111\u1ecbnh c\u1ee7a Methotrexate v\u00e0 Ibuprofen<\/strong><\/h2>\n<h3><strong>2.1. Methotrexate<\/strong><\/h3>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Ung th\u01b0 l\u00e1 nu\u00f4i, b\u1ec7nh b\u1ea1ch c\u1ea7u, ung th\u01b0 v\u00fa.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Ung th\u01b0 ph\u1ed5i, ung th\u01b0 b\u00e0ng quang, ung th\u01b0 \u0111\u1ea7u v\u00e0 c\u1ed5, s\u00e1c-c\u00f4m x\u01b0\u01a1ng, s\u00e1c-c\u00f4m s\u1ee5n, s\u00e1c-c\u00f4m s\u1ee3i.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">B\u1ec7nh v\u1ea3y n\u1ebfn, vi\u00eam kh\u1edbp v\u1ea3y n\u1ebfn, vi\u00eam kh\u1edbp d\u1ea1ng th\u1ea5p, u s\u00f9i d\u1ea1ng n\u1ea5m (u lymph\u00f4 t\u1ebf b\u00e0o T), u lymph\u00f4 kh\u00f4ng Hodgkin\u2026<\/span><\/li>\n<\/ul>\n<h3><strong>2.2. Ibuprofen<\/strong><\/h3>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Gi\u1ea3m \u0111au v\u00e0 ch\u1ed1ng vi\u00eam t\u1eeb nh\u1eb9 \u0111\u1ebfn v\u1eeba: Trong m\u1ed9t s\u1ed1 b\u1ec7nh nh\u01b0 \u0111au \u0111\u1ea7u, \u0111au r\u0103ng. D\u00f9ng Ibuprofen c\u00f3 th\u1ec3 gi\u1ea3m b\u1edbt li\u1ec1u thu\u1ed1c ch\u1ee9a thu\u1ed1c phi\u1ec7n trong \u0111i\u1ec1u tr\u1ecb \u0111au sau \u0111\u1ea1i ph\u1eabu thu\u1eadt hay \u0111au do ung th\u01b0. Vi\u00eam kh\u1edbp d\u1ea1ng th\u1ea5p, vi\u00eam kh\u1edbp d\u1ea1ng th\u1ea5p thanh thi\u1ebfu ni\u00ean.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">H\u1ea1 s\u1ed1t \u1edf tr\u1ebb em.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Ch\u1ee9ng c\u00f2n \u1ed1ng \u0111\u1ed9ng m\u1ea1ch \u1edf tr\u1ebb s\u01a1 sinh thi\u1ebfu th\u00e1ng, d\u01b0\u1edbi 34 tu\u1ea7n. \u0110au b\u1ee5ng kinh.<\/span><\/li>\n<\/ul>\n<h2><strong>3. T\u01b0\u01a1ng t\u00e1c gi\u1eefa Methotrexate v\u00e0 Ibuprofen<\/strong><\/h2>\n<p><span style=\"font-weight: 400;\">D\u00f9ng \u0111\u1ed3ng th\u1eddi v\u1edbi thu\u1ed1c ch\u1ed1ng vi\u00eam kh\u00f4ng steroid (NSAID) c\u00f3 th\u1ec3 l\u00e0m t\u0103ng n\u1ed3ng \u0111\u1ed9 trong huy\u1ebft t\u01b0\u01a1ng v\u00e0 \u0111\u1ed9c t\u00ednh c\u1ee7a Methotrexate.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">C\u01a1 ch\u1ebf \u0111\u01b0\u1ee3c \u0111\u1ec1 xu\u1ea5t l\u00e0 NSAID \u1ee9c ch\u1ebf \u0111\u00e0o th\u1ea3i Methotrexate qua th\u1eadn v\u00e0 ch\u1ea5t chuy\u1ec3n h\u00f3a c\u1ee7a n\u00f3, 7-hydroxymethotrexate, m\u1eb7c d\u00f9 d\u1eef li\u1ec7u t\u1eeb c\u00e1c nghi\u00ean c\u1ee9u d\u01b0\u1ee3c \u0111\u1ed9ng h\u1ecdc kh\u00f4ng nh\u1ea5t qu\u00e1n v\u00e0 m\u00e2u thu\u1eabn. S\u1ef1 d\u1ecbch chuy\u1ec3n Methotrexate li\u00ean k\u1ebft v\u1edbi albumin huy\u1ebft thanh b\u1edfi m\u1ed9t s\u1ed1 NSAID c\u0169ng c\u00f3 th\u1ec3 \u0111\u00f3ng vai tr\u00f2 th\u1ee9 y\u1ebfu.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Nguy c\u01a1 cao nh\u1ea5t \u1edf nh\u1eefng b\u1ec7nh nh\u00e2n d\u00f9ng li\u1ec1u cao Methotrexate v\u00e0 nh\u1eefng ng\u01b0\u1eddi b\u1ecb suy th\u1eadn. Trong c\u00e1c nghi\u00ean c\u1ee9u l\u00e2m s\u00e0ng, d\u00f9ng Methotrexate \u1edf li\u1ec1u 7.5\u00a0 \u0111\u1ebfn 15 mg\/tu\u1ea7n \u0111\u00e3 \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng m\u00e0 kh\u00f4ng c\u00f3 v\u1ea5n \u0111\u1ec1 g\u00ec r\u00f5 r\u00e0ng \u1edf nh\u1eefng b\u1ec7nh nh\u00e2n b\u1ecb vi\u00eam kh\u1edbp d\u1ea1ng th\u1ea5p v\u00e0 c\u0169ng nh\u1eadn \u0111\u01b0\u1ee3c ch\u1ebf \u0111\u1ed9 li\u1ec1u l\u01b0\u1ee3ng li\u00ean t\u1ee5c c\u1ee7a NSAID.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">M\u1ee9c \u0111\u1ed9 t\u01b0\u01a1ng t\u00e1c t\u1eeb nhi\u1ec1u ngu\u1ed3n kh\u00e1c nhau:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Drug: Nghi\u00eam tr\u1ecdng\u00a0<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">WebMD: Nghi\u00eam tr\u1ecdng<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Medscape: Nghi\u00eam tr\u1ecdng<\/span><\/li>\n<\/ul>\n<h2><strong>4. T\u00e1c d\u1ee5ng ph\u1ee5\u00a0<\/strong><\/h2>\n<h3><strong>4.1 T\u00e1c d\u1ee5ng ph\u1ee5 c\u1ee7a Methotrexate<\/strong><\/h3>\n<p><b><i>Th\u01b0\u1eddng g\u1eb7p:<\/i><\/b><span style=\"font-weight: 400;\"> Ch\u00f3ng m\u1eb7t, m\u1ec7t m\u1ecfi, b\u1ec7nh n\u00e3o, \u0111\u1ed9ng kinh, s\u1ed1t, \u1edbn l\u1ea1nh, \u0111au kh\u1edbp, vi\u00eam m\u1ea1ch, ban \u0111\u1ecf da, r\u1ee5ng t\u00f3c, t\u0103ng ho\u1eb7c gi\u1ea3m s\u1eafc t\u1ed1 da, lo\u00e9t mi\u1ec7ng, s\u01b0ng l\u01b0\u1ee1i, vi\u00eam n\u01b0\u1edbu, bu\u1ed3n n\u00f4n, n\u00f4n, \u0111i ngo\u00e0i, ch\u00e1n \u0103n, th\u1ee7ng ru\u1ed9t, gi\u1ea3m b\u1ea1ch c\u1ea7u, ti\u1ec3u c\u1ea7u, xu\u1ea5t huy\u1ebft,&#8230; <\/span><\/p>\n<p><b><i>\u00cdt g\u1eb7p:<\/i><\/b><span style=\"font-weight: 400;\"> H\u1ed9i ch\u1ee9ng th\u1ea7n kinh c\u1ea5p, s\u1ed1c ph\u1ea3n v\u1ec7, vi\u00eam ch\u00e2n r\u0103ng, r\u1ed1i lo\u1ea1n ch\u1ee9c n\u0103ng nh\u1eadn th\u1ee9c, gi\u1ea3m s\u1ee9c \u0111\u1ec1 kh\u00e1ng v\u1edbi nhi\u1ec5m khu\u1ea9n, ban \u0111\u1ecf \u0111a d\u1ea1ng, suy gan, r\u1ed1i lo\u1ea1n lympho b\u00e0o, ho\u1ea1i t\u1eed x\u01b0\u01a1ng v\u00e0 ho\u1ea1i t\u1eed m\u00f4, vi\u00eam m\u00e0ng ngo\u00e0i tim, v\u1ea9y n\u1ebfn, \u0111\u1ed9ng kinh, h\u1ed9i ch\u1ee9ng Stevens-Johnson, t\u1eafc m\u1ea1ch huy\u1ebft kh\u1ed1i.<\/span><\/p>\n<h3><strong>4.2 T\u00e1c d\u1ee5ng ph\u1ee5 c\u1ee7a Ibuprofen<\/strong><\/h3>\n<p><b><i>Th\u01b0\u1eddng g\u1eb7p:<\/i><\/b><span style=\"font-weight: 400;\"> S\u1ed1t, m\u1ecfi m\u1ec7t, ch\u01b0\u1edbng b\u1ee5ng, bu\u1ed3n n\u00f4n, n\u00f4n, nh\u1ee9c \u0111\u1ea7u, hoa m\u1eaft ch\u1ed1ng m\u1eb7t, m\u1ea9n ng\u1ee9a, ngo\u1ea1i ban. <\/span><\/p>\n<p><b><i>\u00cdt g\u1eb7p:<\/i><\/b><span style=\"font-weight: 400;\"> Ph\u1ea3n \u1ee9ng d\u1ecb \u1ee9ng, vi\u00eam m\u0169i, n\u1ed5i m\u00e0y \u0111ay, \u0111au b\u1ee5ng, ch\u1ea3y m\u00e1u d\u1ea1 d\u00e0y \u2013 ru\u1ed9t, l\u00e0m lo\u00e9t d\u1ea1 d\u00e0y ti\u1ebfn tri\u1ec3n, l\u01a1 m\u01a1, m\u1ea5t ng\u1ee7, \u00f9 tai, r\u1ed1i lo\u1ea1n th\u1ecb gi\u00e1c, th\u00ednh l\u1ef1c gi\u1ea3m, th\u1eddi gian ch\u1ea3y m\u00e1u k\u00e9o d\u00e0i. <\/span><\/p>\n<p><b><i>Hi\u1ebfm g\u1eb7p: <\/i><\/b><span style=\"font-weight: 400;\">Ph\u00f9, n\u1ed5i ban, h\u1ed9i ch\u1ee9ng Stevens \u2013 Johnson, r\u1ee5ng t\u00f3c, h\u1ea1 natri, tr\u1ea7m c\u1ea3m, vi\u00eam m\u00e0ng n\u00e3o v\u00f4 khu\u1ea9n v\u00e0 h\u00f4n m\u00ea, nh\u00ecn m\u1edd, r\u1ed1i lo\u1ea1n nh\u00ecn m\u00e0u, gi\u1ea3m th\u1ecb l\u1ef1c do ng\u1ed9 \u0111\u1ed9c thu\u1ed1c, gi\u1ea3m b\u1ea1ch c\u1ea7u, gi\u1ea3m ti\u1ec3u c\u1ea7u, gi\u1ea3m b\u1ea1ch c\u1ea7u trung t\u00ednh, t\u0103ng b\u1ea1ch c\u1ea7u \u00e1i toan, gi\u1ea3m b\u1ea1ch c\u1ea7u h\u1ea1t, thi\u1ebfu m\u00e1u, r\u1ed1i lo\u1ea1n co b\u00f3p t\u00fai m\u1eadt, c\u00e1c th\u1eed nghi\u1ec7m th\u0103m d\u00f2 ch\u1ee9c n\u0103ng gan b\u1ea5t th\u01b0\u1eddng, nhi\u1ec5m \u0111\u1ed9c gan, vi\u00eam ru\u1ed9t ho\u1ea1i t\u1eed, h\u1ed9i ch\u1ee9ng Crohn, vi\u00eam t\u1ee5y, vi\u00eam b\u00e0ng quang, \u0111\u00e1i ra m\u00e1u, suy th\u1eadn c\u1ea5p, vi\u00eam th\u1eadn k\u1ebd, h\u1ed9i ch\u1ee9ng th\u1eadn h\u01b0, nh\u1ea1y c\u1ea3m v\u1edbi \u00e1nh s\u00e1ng.<\/span><\/p>\n<h3><strong>4.3 T\u00e1c d\u1ee5ng ph\u1ee5 c\u00f3 th\u1ec3 x\u1ea3y ra khi s\u1eed d\u1ee5ng Methotrexate v\u00e0 Ibuprofen c\u00f9ng nhau<\/strong><\/h3>\n<p><span style=\"font-weight: 400;\">\u1ee8c ch\u1ebf t\u1ee7y x\u01b0\u01a1ng nghi\u00eam tr\u1ecdng v\u00e0 \u0111\u00f4i khi g\u00e2y t\u1eed vong, thi\u1ebfu m\u00e1u b\u1ea5t s\u1ea3n, \u0111\u1ed9c t\u00ednh tr\u00ean \u0111\u01b0\u1eddng ti\u00eau h\u00f3a v\u00e0 \u0111\u1ed9c t\u00ednh tr\u00ean th\u1eadn \u0111\u00e3 \u0111\u01b0\u1ee3c b\u00e1o c\u00e1o khi s\u1eed d\u1ee5ng \u0111\u1ed3ng th\u1eddi Methotrexate v\u1edbi NSAID.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Khi d\u00f9ng \u0111\u1ed3ng th\u1eddi NSAID v\u1edbi Methotrexate li\u1ec1u th\u1ea5p h\u01a1n c\u00f3 b\u00e1o c\u00e1o t\u00e1c d\u1ee5ng ph\u1ee5 v\u1ec1 vi\u00eam mi\u1ec7ng, vi\u00eam ph\u1ed5i, nhi\u1ec5m \u0111\u1ed9c t\u1ee7y x\u01b0\u01a1ng v\u00e0 t\u1eed vong .<\/span><\/p>\n<p>B\u1ec7nh nh\u00e2n n\u00ean li\u00ean h\u1ec7 v\u1edbi b\u00e1c s\u0129 n\u1ebfu xu\u1ea5t hi\u1ec7n c\u00e1c t\u00e1c d\u1ee5ng ph\u1ee5 sau \u0111\u00e2y:<\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Lo\u00e9t mi\u1ec7ng ho\u1eb7c l\u1edf lo\u00e9t<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">N\u00f4n m\u1eeda\u00a0<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Ti\u00eau ch\u1ea3y\u00a0<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Ph\u00e1t ban<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">\u0102n m\u1ea5t ngon<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">\u0110au ho\u1eb7c s\u01b0ng kh\u1edbp\u00a0<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Da v\u00e0 m\u1eaft \u0111\u1ed5i m\u00e0u v\u00e0ng<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">N\u01b0\u1edbc ti\u1ec3u \u0111\u1eadm<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">H\u1ee5t h\u01a1i<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Ho khan<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Xanh xao<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Ch\u00f3ng m\u1eb7t ho\u1eb7c ng\u1ea5t x\u1ec9u<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">B\u1ea7m t\u00edm ho\u1eb7c ch\u1ea3y m\u00e1u b\u1ea5t th\u01b0\u1eddng<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">\u0110\u1ed9ng kinh\u00a0<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Nhi\u1ec5m tr\u00f9ng\u00a0<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">C\u00e1c tri\u1ec7u ch\u1ee9ng gi\u1ed1ng c\u00fam ( s\u1ed1t , \u1edbn l\u1ea1nh, \u0111au nh\u1ee9c c\u01a1 th\u1ec3, \u0111au h\u1ecdng , y\u1ebfu c\u01a1).\u00a0<\/span><\/li>\n<\/ul>\n<h2><strong>5. Bi\u1ec7n ph\u00e1p x\u1eed l\u00fd<\/strong><\/h2>\n<ul>\n<li><span style=\"font-weight: 400;\">Thay \u0111\u1ed5i li\u1ec1u l\u01b0\u1ee3ng ho\u1eb7c th\u1eddi gian s\u1eed d\u1ee5ng thu\u1ed1c<\/span><\/li>\n<li><span style=\"font-weight: 400;\">Thay th\u1ebf b\u1eb1ng c\u00e1c lo\u1ea1i thu\u1ed1c kh\u00e1c kh\u00f4ng t\u01b0\u01a1ng t\u00e1c v\u1edbi nhau<\/span><\/li>\n<li><span style=\"font-weight: 400;\">T\u0103ng c\u01b0\u1eddng gi\u00e1m s\u00e1t v\u00e0 theo d\u00f5i t\u00ecnh tr\u1ea1ng s\u1ee9c kh\u1ecfe c\u1ee7a b\u1ec7nh nh\u00e2n<\/span><\/li>\n<\/ul>\n<h2><strong>6. K\u1ebft lu\u1eadn<\/strong><\/h2>\n<p>T\u01b0\u01a1ng t\u00e1c thu\u1ed1c gi\u1eefa Methotrexate v\u00e0 Ibuprofen c\u00f3 th\u1ec3 g\u00e2y \u1ea3nh h\u01b0\u1edfng \u0111\u1ebfn hi\u1ec7u qu\u1ea3 \u0111i\u1ec1u tr\u1ecb v\u00e0 g\u00e2y t\u00e1c d\u1ee5ng ph\u1ee5 \u0111\u1ed1i v\u1edbi b\u1ec7nh nh\u00e2n. Do \u0111\u00f3, c\u1ea7n t\u0103ng c\u01b0\u1eddng gi\u00e1m s\u00e1t v\u00e0 h\u1ea1n ch\u1ebf t\u01b0\u01a1ng t\u00e1c gi\u1eefa hai lo\u1ea1i thu\u1ed1c n\u00e0y trong qu\u00e1 tr\u00ecnh \u0111i\u1ec1u tr\u1ecb \u0111\u1ec3 \u0111\u1ea3m b\u1ea3o an to\u00e0n v\u00e0 hi\u1ec7u qu\u1ea3 \u0111i\u1ec1u tr\u1ecb.<\/p>\n<p><span style=\"font-weight: 400;\">Ngu\u1ed3n: D\u01b0\u1ee3c th\u01b0 Qu\u1ed1c gia Vi\u1ec7t Nam, Drug.com<\/span><\/p>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Methotrexate v\u00e0 Ibuprofen l\u00e0 hai lo\u1ea1i thu\u1ed1c th\u01b0\u1eddng \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng \u0111\u1ec3 \u0111i\u1ec1u tr\u1ecb c\u00e1c b\u1ec7nh li\u00ean quan \u0111\u1ebfn vi\u00eam v\u00e0 \u0111au. Khi s\u1eed d\u1ee5ng c\u00f9ng l\u00fac, t\u01b0\u01a1ng t\u00e1c gi\u1eefa hai lo\u1ea1i thu\u1ed1c n\u00e0y c\u00f3 th\u1ec3 \u1ea3nh h\u01b0\u1edfng \u0111\u1ebfn hi\u1ec7u qu\u1ea3 \u0111i\u1ec1u tr\u1ecb, g\u00e2y ra c\u00e1c t\u00e1c d\u1ee5ng ph\u1ee5 v\u00e0 th\u1eadm ch\u00ed c\u00f3 th\u1ec3 g\u00e2y [&hellip;]<\/p>\n","protected":false},"author":53,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[12],"tags":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v20.4 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Methotrexate v\u00e0 Ibuprofen: C\u01a1 ch\u1ebf, ch\u1ec9 \u0111\u1ecbnh, t\u01b0\u01a1ng t\u00e1c thu\u1ed1c<\/title>\n<meta name=\"description\" content=\"Methotrexate v\u00e0 Ibuprofen l\u00e0 hai lo\u1ea1i thu\u1ed1c th\u01b0\u1eddng \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng \u0111\u1ec3 \u0111i\u1ec1u tr\u1ecb c\u00e1c b\u1ec7nh li\u00ean quan \u0111\u1ebfn vi\u00eam v\u00e0 \u0111au. T\u01b0\u01a1ng t\u00e1c thu\u1ed1c\" \/>\n<meta name=\"robots\" content=\"noindex, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Methotrexate v\u00e0 Ibuprofen: C\u01a1 ch\u1ebf, ch\u1ec9 \u0111\u1ecbnh, t\u01b0\u01a1ng t\u00e1c thu\u1ed1c\" \/>\n<meta property=\"og:description\" content=\"Methotrexate v\u00e0 Ibuprofen l\u00e0 hai lo\u1ea1i thu\u1ed1c th\u01b0\u1eddng \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng \u0111\u1ec3 \u0111i\u1ec1u tr\u1ecb c\u00e1c b\u1ec7nh li\u00ean quan \u0111\u1ebfn vi\u00eam v\u00e0 \u0111au. T\u01b0\u01a1ng t\u00e1c thu\u1ed1c\" \/>\n<meta property=\"og:url\" content=\"http:\/\/noithathoaphat.in\/ctv\/index.php\/2023\/04\/22\/tuong-tac-thuoc-giua-methotrexate-ibuprofen\/\" \/>\n<meta property=\"og:site_name\" content=\"Vinmec\" \/>\n<meta property=\"article:published_time\" content=\"2023-04-22T16:14:59+00:00\" \/>\n<meta property=\"og:image\" content=\"http:\/\/noithathoaphat.in\/ctv\/wp-content\/uploads\/2023\/04\/Methotrexate-1-300x300.jpg\" \/>\n<meta name=\"author\" content=\"D\u01b0\u01a1ng Ho\u00e0ng Kim Ki\u1ec1u\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"D\u01b0\u01a1ng Ho\u00e0ng Kim Ki\u1ec1u\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"7 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"http:\/\/noithathoaphat.in\/ctv\/index.php\/2023\/04\/22\/tuong-tac-thuoc-giua-methotrexate-ibuprofen\/\",\"url\":\"http:\/\/noithathoaphat.in\/ctv\/index.php\/2023\/04\/22\/tuong-tac-thuoc-giua-methotrexate-ibuprofen\/\",\"name\":\"Methotrexate v\u00e0 Ibuprofen: C\u01a1 ch\u1ebf, ch\u1ec9 \u0111\u1ecbnh, t\u01b0\u01a1ng t\u00e1c thu\u1ed1c\",\"isPartOf\":{\"@id\":\"http:\/\/noithathoaphat.in\/ctv\/#website\"},\"datePublished\":\"2023-04-22T16:14:59+00:00\",\"dateModified\":\"2023-04-22T16:14:59+00:00\",\"author\":{\"@id\":\"http:\/\/noithathoaphat.in\/ctv\/#\/schema\/person\/0ed39354e8983ddf7029fdd963160052\"},\"description\":\"Methotrexate v\u00e0 Ibuprofen l\u00e0 hai lo\u1ea1i thu\u1ed1c th\u01b0\u1eddng \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng \u0111\u1ec3 \u0111i\u1ec1u tr\u1ecb c\u00e1c b\u1ec7nh li\u00ean quan \u0111\u1ebfn vi\u00eam v\u00e0 \u0111au. T\u01b0\u01a1ng t\u00e1c thu\u1ed1c\",\"breadcrumb\":{\"@id\":\"http:\/\/noithathoaphat.in\/ctv\/index.php\/2023\/04\/22\/tuong-tac-thuoc-giua-methotrexate-ibuprofen\/#breadcrumb\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"http:\/\/noithathoaphat.in\/ctv\/index.php\/2023\/04\/22\/tuong-tac-thuoc-giua-methotrexate-ibuprofen\/\"]}]},{\"@type\":\"BreadcrumbList\",\"@id\":\"http:\/\/noithathoaphat.in\/ctv\/index.php\/2023\/04\/22\/tuong-tac-thuoc-giua-methotrexate-ibuprofen\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"http:\/\/noithathoaphat.in\/ctv\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Methotrexate v\u00e0 Ibuprofen: C\u01a1 ch\u1ebf, ch\u1ec9 \u0111\u1ecbnh, t\u01b0\u01a1ng t\u00e1c thu\u1ed1c\"}]},{\"@type\":\"WebSite\",\"@id\":\"http:\/\/noithathoaphat.in\/ctv\/#website\",\"url\":\"http:\/\/noithathoaphat.in\/ctv\/\",\"name\":\"Vinmec\",\"description\":\"H\u1ec7 th\u1ed1ng Y t\u1ebf Vinmec\",\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"http:\/\/noithathoaphat.in\/ctv\/?s={search_term_string}\"},\"query-input\":\"required name=search_term_string\"}],\"inLanguage\":\"en-US\"},{\"@type\":\"Person\",\"@id\":\"http:\/\/noithathoaphat.in\/ctv\/#\/schema\/person\/0ed39354e8983ddf7029fdd963160052\",\"name\":\"D\u01b0\u01a1ng Ho\u00e0ng Kim Ki\u1ec1u\",\"image\":{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"http:\/\/noithathoaphat.in\/ctv\/#\/schema\/person\/image\/\",\"url\":\"http:\/\/0.gravatar.com\/avatar\/fb5361681d22e08411761f484eed73e7?s=96&d=mm&r=g\",\"contentUrl\":\"http:\/\/0.gravatar.com\/avatar\/fb5361681d22e08411761f484eed73e7?s=96&d=mm&r=g\",\"caption\":\"D\u01b0\u01a1ng Ho\u00e0ng Kim Ki\u1ec1u\"},\"url\":\"http:\/\/noithathoaphat.in\/ctv\/index.php\/author\/duongkieu340gmail-com\/\"}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"Methotrexate v\u00e0 Ibuprofen: C\u01a1 ch\u1ebf, ch\u1ec9 \u0111\u1ecbnh, t\u01b0\u01a1ng t\u00e1c thu\u1ed1c","description":"Methotrexate v\u00e0 Ibuprofen l\u00e0 hai lo\u1ea1i thu\u1ed1c th\u01b0\u1eddng \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng \u0111\u1ec3 \u0111i\u1ec1u tr\u1ecb c\u00e1c b\u1ec7nh li\u00ean quan \u0111\u1ebfn vi\u00eam v\u00e0 \u0111au. T\u01b0\u01a1ng t\u00e1c thu\u1ed1c","robots":{"index":"noindex","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"og_locale":"en_US","og_type":"article","og_title":"Methotrexate v\u00e0 Ibuprofen: C\u01a1 ch\u1ebf, ch\u1ec9 \u0111\u1ecbnh, t\u01b0\u01a1ng t\u00e1c thu\u1ed1c","og_description":"Methotrexate v\u00e0 Ibuprofen l\u00e0 hai lo\u1ea1i thu\u1ed1c th\u01b0\u1eddng \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng \u0111\u1ec3 \u0111i\u1ec1u tr\u1ecb c\u00e1c b\u1ec7nh li\u00ean quan \u0111\u1ebfn vi\u00eam v\u00e0 \u0111au. T\u01b0\u01a1ng t\u00e1c thu\u1ed1c","og_url":"http:\/\/noithathoaphat.in\/ctv\/index.php\/2023\/04\/22\/tuong-tac-thuoc-giua-methotrexate-ibuprofen\/","og_site_name":"Vinmec","article_published_time":"2023-04-22T16:14:59+00:00","og_image":[{"url":"http:\/\/noithathoaphat.in\/ctv\/wp-content\/uploads\/2023\/04\/Methotrexate-1-300x300.jpg"}],"author":"D\u01b0\u01a1ng Ho\u00e0ng Kim Ki\u1ec1u","twitter_card":"summary_large_image","twitter_misc":{"Written by":"D\u01b0\u01a1ng Ho\u00e0ng Kim Ki\u1ec1u","Est. reading time":"7 minutes"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"WebPage","@id":"http:\/\/noithathoaphat.in\/ctv\/index.php\/2023\/04\/22\/tuong-tac-thuoc-giua-methotrexate-ibuprofen\/","url":"http:\/\/noithathoaphat.in\/ctv\/index.php\/2023\/04\/22\/tuong-tac-thuoc-giua-methotrexate-ibuprofen\/","name":"Methotrexate v\u00e0 Ibuprofen: C\u01a1 ch\u1ebf, ch\u1ec9 \u0111\u1ecbnh, t\u01b0\u01a1ng t\u00e1c thu\u1ed1c","isPartOf":{"@id":"http:\/\/noithathoaphat.in\/ctv\/#website"},"datePublished":"2023-04-22T16:14:59+00:00","dateModified":"2023-04-22T16:14:59+00:00","author":{"@id":"http:\/\/noithathoaphat.in\/ctv\/#\/schema\/person\/0ed39354e8983ddf7029fdd963160052"},"description":"Methotrexate v\u00e0 Ibuprofen l\u00e0 hai lo\u1ea1i thu\u1ed1c th\u01b0\u1eddng \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng \u0111\u1ec3 \u0111i\u1ec1u tr\u1ecb c\u00e1c b\u1ec7nh li\u00ean quan \u0111\u1ebfn vi\u00eam v\u00e0 \u0111au. T\u01b0\u01a1ng t\u00e1c thu\u1ed1c","breadcrumb":{"@id":"http:\/\/noithathoaphat.in\/ctv\/index.php\/2023\/04\/22\/tuong-tac-thuoc-giua-methotrexate-ibuprofen\/#breadcrumb"},"inLanguage":"en-US","potentialAction":[{"@type":"ReadAction","target":["http:\/\/noithathoaphat.in\/ctv\/index.php\/2023\/04\/22\/tuong-tac-thuoc-giua-methotrexate-ibuprofen\/"]}]},{"@type":"BreadcrumbList","@id":"http:\/\/noithathoaphat.in\/ctv\/index.php\/2023\/04\/22\/tuong-tac-thuoc-giua-methotrexate-ibuprofen\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"http:\/\/noithathoaphat.in\/ctv\/"},{"@type":"ListItem","position":2,"name":"Methotrexate v\u00e0 Ibuprofen: C\u01a1 ch\u1ebf, ch\u1ec9 \u0111\u1ecbnh, t\u01b0\u01a1ng t\u00e1c thu\u1ed1c"}]},{"@type":"WebSite","@id":"http:\/\/noithathoaphat.in\/ctv\/#website","url":"http:\/\/noithathoaphat.in\/ctv\/","name":"Vinmec","description":"H\u1ec7 th\u1ed1ng Y t\u1ebf Vinmec","potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"http:\/\/noithathoaphat.in\/ctv\/?s={search_term_string}"},"query-input":"required name=search_term_string"}],"inLanguage":"en-US"},{"@type":"Person","@id":"http:\/\/noithathoaphat.in\/ctv\/#\/schema\/person\/0ed39354e8983ddf7029fdd963160052","name":"D\u01b0\u01a1ng Ho\u00e0ng Kim Ki\u1ec1u","image":{"@type":"ImageObject","inLanguage":"en-US","@id":"http:\/\/noithathoaphat.in\/ctv\/#\/schema\/person\/image\/","url":"http:\/\/0.gravatar.com\/avatar\/fb5361681d22e08411761f484eed73e7?s=96&d=mm&r=g","contentUrl":"http:\/\/0.gravatar.com\/avatar\/fb5361681d22e08411761f484eed73e7?s=96&d=mm&r=g","caption":"D\u01b0\u01a1ng Ho\u00e0ng Kim Ki\u1ec1u"},"url":"http:\/\/noithathoaphat.in\/ctv\/index.php\/author\/duongkieu340gmail-com\/"}]}},"_links":{"self":[{"href":"http:\/\/noithathoaphat.in\/ctv\/index.php\/wp-json\/wp\/v2\/posts\/23690"}],"collection":[{"href":"http:\/\/noithathoaphat.in\/ctv\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"http:\/\/noithathoaphat.in\/ctv\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"http:\/\/noithathoaphat.in\/ctv\/index.php\/wp-json\/wp\/v2\/users\/53"}],"replies":[{"embeddable":true,"href":"http:\/\/noithathoaphat.in\/ctv\/index.php\/wp-json\/wp\/v2\/comments?post=23690"}],"version-history":[{"count":7,"href":"http:\/\/noithathoaphat.in\/ctv\/index.php\/wp-json\/wp\/v2\/posts\/23690\/revisions"}],"predecessor-version":[{"id":27089,"href":"http:\/\/noithathoaphat.in\/ctv\/index.php\/wp-json\/wp\/v2\/posts\/23690\/revisions\/27089"}],"wp:attachment":[{"href":"http:\/\/noithathoaphat.in\/ctv\/index.php\/wp-json\/wp\/v2\/media?parent=23690"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"http:\/\/noithathoaphat.in\/ctv\/index.php\/wp-json\/wp\/v2\/categories?post=23690"},{"taxonomy":"post_tag","embeddable":true,"href":"http:\/\/noithathoaphat.in\/ctv\/index.php\/wp-json\/wp\/v2\/tags?post=23690"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}