{"id":23472,"date":"2023-04-17T20:44:50","date_gmt":"2023-04-17T13:44:50","guid":{"rendered":"http:\/\/noithathoaphat.in\/ctv\/?p=23472"},"modified":"2023-04-18T11:45:23","modified_gmt":"2023-04-18T04:45:23","slug":"tong-quan-ve-lieu-phap-hormone-trong-dieu-tri-ung-thu-vu","status":"publish","type":"post","link":"http:\/\/noithathoaphat.in\/ctv\/index.php\/2023\/04\/17\/tong-quan-ve-lieu-phap-hormone-trong-dieu-tri-ung-thu-vu\/","title":{"rendered":"T\u1ed5ng quan v\u1ec1 li\u1ec7u ph\u00e1p hormone trong \u0111i\u1ec1u tr\u1ecb ung th\u01b0 v\u00fa"},"content":{"rendered":"<p>Ung th\u01b0 v\u00fa l\u00e0 lo\u1ea1i ung th\u01b0 ph\u1ed5 bi\u1ebfn nh\u1ea5t \u1edf ph\u1ee5 n\u1eef tr\u00ean th\u1ebf gi\u1edbi v\u00e0 t\u00e1c \u0111\u1ed9ng \u0111\u00e1ng k\u1ec3 \u0111\u1ebfn s\u1ee9c kh\u1ecfe to\u00e0n c\u1ea7u. Li\u1ec7u ph\u00e1p hormone l\u00e0 m\u1ed9t ph\u01b0\u01a1ng th\u1ee9c \u0111i\u1ec1u tr\u1ecb quan tr\u1ecdng \u0111\u1ed1i v\u1edbi ung th\u01b0 v\u00fa, \u0111\u1eb7c bi\u1ec7t \u0111\u1ed1i v\u1edbi ung th\u01b0 v\u00fa ph\u1ee5 thu\u1ed9c n\u1ed9i ti\u1ebft (HR+). Trong b\u00e0i vi\u1ebft n\u00e0y, ch\u00fang t\u00f4i s\u1ebd cung c\u1ea5p m\u1ed9t c\u00e1i nh\u00ecn t\u1ed5ng quan v\u1ec1 li\u1ec7u ph\u00e1p hormone trong \u0111i\u1ec1u tr\u1ecb ung th\u01b0 v\u00fa cho c\u00e1c chuy\u00ean gia y t\u1ebf.<\/p>\n<figure id=\"attachment_23483\" aria-describedby=\"caption-attachment-23483\" style=\"width: 300px\" class=\"wp-caption aligncenter\"><img decoding=\"async\" loading=\"lazy\" class=\"size-medium wp-image-23483\" src=\"http:\/\/noithathoaphat.in\/ctv\/wp-content\/uploads\/2023\/04\/20190428_161006_551300_estrogen.max-1800x1800-1-300x200.jpg\" alt=\"lieu-phap-hormone-trong-dieu-tri-ung-thu-vu\" width=\"300\" height=\"200\" srcset=\"http:\/\/noithathoaphat.in\/ctv\/wp-content\/uploads\/2023\/04\/20190428_161006_551300_estrogen.max-1800x1800-1-300x200.jpg 300w, http:\/\/noithathoaphat.in\/ctv\/wp-content\/uploads\/2023\/04\/20190428_161006_551300_estrogen.max-1800x1800-1.jpg 500w\" sizes=\"(max-width: 300px) 100vw, 300px\" \/><figcaption id=\"caption-attachment-23483\" class=\"wp-caption-text\">Minh h\u1ecda v\u1ec1 li\u1ec7u ph\u00e1p hormone trong \u0111i\u1ec1u tr\u1ecb ung th\u01b0 v\u00fa<\/figcaption><\/figure>\n<h2>1. Vai tr\u00f2 c\u1ee7a li\u1ec7u ph\u00e1p hormone trong \u0111i\u1ec1u tr\u1ecb ung th\u01b0 v\u00fa<\/h2>\n<p>Ung th\u01b0 v\u00fa c\u00f3 th\u1ec3 \u0111\u01b0\u1ee3c ph\u00e2n lo\u1ea1i d\u1ef1a tr\u00ean s\u1ef1 hi\u1ec7n di\u1ec7n hay v\u1eafng m\u1eb7t c\u1ee7a c\u00e1c th\u1ee5 th\u1ec3 hormone. Ung th\u01b0 v\u00fa ph\u1ee5 thu\u1ed9c n\u1ed9i ti\u1ebft (hormone receptor-positive, vi\u1ebft t\u1eaft l\u00e0 HR +) l\u00e0 c\u00e1c t\u1ebf b\u00e0o ung th\u01b0 c\u00f3 th\u1ee5 th\u1ec3 estrogen v\u00e0 \/ ho\u1eb7c progesterone, trong khi ung th\u01b0 v\u00fa kh\u00f4ng ph\u1ee5 thu\u1ed9c n\u1ed9i ti\u1ebft (hormone receptor-negative, vi\u1ebft t\u1eaft l\u00e0 HR-) kh\u00f4ng c\u00f3 c\u00e1c th\u1ee5 th\u1ec3 n\u00e0y. Kho\u1ea3ng 60-70% c\u00e1c b\u1ec7nh ung th\u01b0 v\u00fa l\u00e0 HR +, v\u1edbi t\u1ef7 l\u1ec7 m\u1eafc cao h\u01a1n \u1edf ph\u1ee5 n\u1eef m\u00e3n kinh. Ung th\u01b0 v\u00fa HR+ c\u00f3 xu h\u01b0\u1edbng ti\u00ean l\u01b0\u1ee3ng t\u1ed1t h\u01a1n so v\u1edbi ung th\u01b0 v\u00fa HR-<\/p>\n<p>Li\u1ec7u ph\u00e1p hormone ho\u1ea1t \u0111\u1ed9ng b\u1eb1ng c\u00e1ch ng\u0103n ch\u1eb7n t\u00e1c d\u1ee5ng c\u1ee7a estrogen v\u00e0 progesterone, hai hormone c\u00f3 th\u1ec3 k\u00edch th\u00edch s\u1ef1 ph\u00e1t tri\u1ec3n c\u1ee7a c\u00e1c t\u1ebf b\u00e0o ung th\u01b0 v\u00fa.<\/p>\n<h2>2. C\u00e1c nh\u00f3m thu\u1ed1c \u0111i\u1ec3n h\u00ecnh<\/h2>\n<p>M\u1ed9t s\u1ed1 li\u1ec7u ph\u00e1p hormone trong \u0111i\u1ec1u tr\u1ecb ung th\u01b0 v\u00fa c\u00f3 th\u1ec3 k\u1ec3 \u0111\u1ebfn nh\u01b0:<\/p>\n<ul>\n<li><strong>Nh\u00f3m \u0111i\u1ec1u h\u00f2a th\u1ee5 th\u1ec3 estrogen ch\u1ecdn l\u1ecdc (SERMs)<\/strong>: Nh\u1eefng lo\u1ea1i thu\u1ed1c n\u00e0y ng\u0103n ch\u1eb7n t\u00e1c d\u1ee5ng c\u1ee7a estrogen \u0111\u1ed1i v\u1edbi c\u00e1c t\u1ebf b\u00e0o ung th\u01b0 v\u00fa. Tamoxifen l\u00e0 thu\u1ed1c \u0111i\u1ec3n h\u00ecnh trong nh\u00f3m n\u00e0y.<\/li>\n<li><strong>Nh\u00f3m thu\u1ed1c \u1ee9c ch\u1ebf aromatase (AIs):<\/strong> Nh\u1eefng lo\u1ea1i thu\u1ed1c n\u00e0y l\u00e0m gi\u1ea3m l\u01b0\u1ee3ng estrogen trong c\u01a1 th\u1ec3 b\u1eb1ng c\u00e1ch ng\u0103n ch\u1eb7n enzyme aromatase (enzym gi\u00fap chuy\u1ec3n \u0111\u1ed5i androgen th\u00e0nh estrogen). M\u1ed9t s\u1ed1 thu\u1ed1c thu\u1ed9c nh\u00f3m n\u00e0y bao g\u1ed3m anastrozole, letrozole v\u00e0 exemestane, \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng \u0111i\u1ec1u tr\u1ecb ung th\u01b0 v\u00fa \u1edf ph\u1ee5 n\u1eef m\u00e3n kinh.<\/li>\n<li><strong>Nh\u00f3m \u0111\u1ed3ng v\u1eadn GnRH:<\/strong> Nh\u1eefng lo\u1ea1i thu\u1ed1c n\u00e0y l\u00e0m gi\u1ea3m l\u01b0\u1ee3ng estrogen \u1edf ph\u1ee5 n\u1eef ti\u1ec1n m\u00e3n kinh b\u1eb1ng c\u00e1ch \u1ee9c ch\u1ebf s\u1ea3n xu\u1ea5t estrogen trong bu\u1ed3ng tr\u1ee9ng. C\u00e1c thu\u1ed1c \u0111i\u1ec3n h\u00ecnh bao g\u1ed3m goserelin v\u00e0 leuprolide.<\/li>\n<li><strong>Nh\u00f3m \u0111\u1ed1i v\u1eadn Estrogen:<\/strong> Nh\u1eefng lo\u1ea1i thu\u1ed1c n\u00e0y ng\u0103n ch\u1eb7n t\u00e1c d\u1ee5ng c\u1ee7a estrogen \u0111\u1ed1i v\u1edbi c\u00e1c t\u1ebf b\u00e0o ung th\u01b0 v\u00fa v\u00e0 c\u0169ng l\u00e0m gi\u1ea3m s\u1ed1 l\u01b0\u1ee3ng th\u1ee5 th\u1ec3 estrogen tr\u00ean c\u00e1c t\u1ebf b\u00e0o n\u00e0y. Fulvestrant thu\u1ed9c nh\u00f3m n\u00e0y l\u00e0 thu\u1ed1c th\u01b0\u1eddng \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng<\/li>\n<\/ul>\n<h2>3. S\u1eed d\u1ee5ng li\u1ec7u ph\u00e1p hormone \u1edf ph\u1ee5 n\u1eef giai \u0111o\u1ea1n ti\u1ec1n m\u00e3n kinh v\u00e0 m\u00e3n kinh.<\/h2>\n<p>Li\u1ec7u ph\u00e1p hormone c\u00f3 th\u1ec3 \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng \u1edf c\u1ea3 ph\u1ee5 n\u1eef ti\u1ec1n m\u00e3n kinh v\u00e0 m\u00e3n kinh b\u1ecb ung th\u01b0 v\u00fa. \u1ede ph\u1ee5 n\u1eef ti\u1ec1n m\u00e3n kinh, nh\u00f3m \u0111\u1ed3ng v\u1eadn GnRH \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng \u0111\u1ec3 ng\u0103n ch\u1eb7n vi\u1ec7c s\u1ea3n xu\u1ea5t estrogen trong bu\u1ed3ng tr\u1ee9ng. Trong khi \u1edf ph\u1ee5 n\u1eef m\u00e3n kinh, nh\u00f3m \u1ee9c ch\u1ebf aromatase \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng \u0111\u1ec3 ng\u0103n ch\u1eb7n vi\u1ec7c chuy\u1ec3n \u0111\u1ed5i androgen th\u00e0nh estrogen. Tamoxifen c\u00f3 th\u1ec3 \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng \u1edf c\u1ea3 ph\u1ee5 n\u1eef ti\u1ec1n m\u00e3n kinh v\u00e0 m\u00e3n kinh b\u1ecb ung th\u01b0 v\u00fa.<\/p>\n<h2>4. S\u1eed d\u1ee5ng li\u1ec7u ph\u00e1p hormone k\u1ebft h\u1ee3p v\u1edbi c\u00e1c ph\u01b0\u01a1ng ph\u00e1p \u0111i\u1ec1u tr\u1ecb kh\u00e1c<\/h2>\n<p>Li\u1ec7u ph\u00e1p hormone c\u00f3 th\u1ec3 k\u1ebft h\u1ee3p v\u1edbi ph\u1eabu thu\u1eadt, x\u1ea1 tr\u1ecb hay h\u00f3a tr\u1ecb, c\u00f3 th\u1ec3 \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng \u0111\u1ec3:<\/p>\n<ul>\n<li><strong>Li\u1ec7u ph\u00e1p t\u00e2n b\u1ed5 tr\u1ee3:<\/strong> l\u00e0m kh\u1ed1i u nh\u1ecf l\u1ea1i tr\u01b0\u1edbc khi ph\u1eabu thu\u1eadt ho\u1eb7c x\u1ea1 tr\u1ecb<\/li>\n<li><strong>Li\u1ec7u ph\u00e1p b\u1ed5 tr\u1ee3:<\/strong> l\u00e0m gi\u1ea3m nguy c\u01a1 t\u00e1i ph\u00e1t ung th\u01b0 sau \u0111i\u1ec1u tr\u1ecb ch\u00ednh v\u00e0 lo\u1ea1i b\u1ecf c\u00e1c t\u1ebf b\u00e0o ung th\u01b0 di c\u0103n sang c\u00e1c b\u1ed9 ph\u1eadn kh\u00e1c.<\/li>\n<\/ul>\n<h2>5. Qu\u1ea3n l\u00fd t\u00e1c d\u1ee5ng ph\u1ee5 c\u1ee7a li\u1ec7u ph\u00e1p hormone<\/h2>\n<p>Vi\u1ec7c qu\u1ea3n l\u00fd c\u00e1c t\u00e1c d\u1ee5ng ph\u1ee5 c\u1ee7a li\u1ec7u ph\u00e1p hormone l\u00e0 m\u1ed9t kh\u00eda c\u1ea1nh quan tr\u1ecdng c\u1ee7a \u0111i\u1ec1u tr\u1ecb ung th\u01b0 v\u00fa, v\u00ec n\u00f3 c\u00f3 th\u1ec3 \u1ea3nh h\u01b0\u1edfng \u0111\u00e1ng k\u1ec3 \u0111\u1ebfn ch\u1ea5t l\u01b0\u1ee3ng cu\u1ed9c s\u1ed1ng c\u1ee7a ph\u1ee5 n\u1eef \u0111ang \u0111i\u1ec1u tr\u1ecb. D\u01b0\u1edbi \u0111\u00e2y l\u00e0 m\u1ed9t s\u1ed1 t\u00e1c d\u1ee5ng ph\u1ee5 th\u01b0\u1eddng g\u1eb7p c\u1ee7a li\u1ec7u ph\u00e1p hormone:<\/p>\n<ul>\n<li>B\u1ed1c h\u1ecfa<\/li>\n<li>Kh\u00f4 \u00e2m \u0111\u1ea1o<\/li>\n<li>Lo\u00e3ng x\u01b0\u01a1ng<\/li>\n<li>Thay \u0111\u1ed5i chu k\u1ef3 kinh nguy\u1ec7t n\u1ebfu b\u1ec7nh nh\u00e2n ch\u01b0a \u0111\u1ebfn tu\u1ed5i m\u00e3n kinh<\/li>\n<li>R\u1ed1i lo\u1ea1n ch\u1ee9c n\u0103ng t\u00ecnh d\u1ee5c<\/li>\n<li>Bu\u1ed3n n\u00f4n<\/li>\n<li>M\u1ec7t m\u1ecfi<\/li>\n<li>Thay \u0111\u1ed5i t\u00e2m tr\u1ea1ng.<\/li>\n<\/ul>\n<p>M\u1ed9t s\u1ed1 chi\u1ebfn l\u01b0\u1ee3c \u0111\u1ec3 ki\u1ec3m so\u00e1t c\u00e1c t\u00e1c d\u1ee5ng ph\u1ee5 n\u00e0y:<\/p>\n<ul>\n<li>Thay \u0111\u1ed5i l\u1ed1i s\u1ed1ng: Thay \u0111\u1ed5i l\u1ed1i s\u1ed1ng nh\u01b0 t\u1eadp th\u1ec3 d\u1ee5c th\u01b0\u1eddng xuy\u00ean, \u0103n u\u1ed1ng l\u00e0nh m\u1ea1nh v\u00e0 ki\u1ec3m so\u00e1t c\u0103ng th\u1eb3ng c\u00f3 th\u1ec3 gi\u00fap gi\u1ea3m m\u1ee9c \u0111\u1ed9 nghi\u00eam tr\u1ecdng c\u1ee7a c\u00e1c t\u00e1c d\u1ee5ng ph\u1ee5.<\/li>\n<li>S\u1eed d\u1ee5ng thu\u1ed1c l\u00e0m gi\u1ea3m t\u00e1c d\u1ee5ng ph\u1ee5: M\u1ed9t s\u1ed1 lo\u1ea1i thu\u1ed1c nh\u01b0 thu\u1ed1c ch\u1ed1ng tr\u1ea7m c\u1ea3m c\u00f3 th\u1ec3 gi\u00fap gi\u1ea3m b\u1edbt c\u00e1c c\u01a1n b\u1ed1c h\u1ecfa v\u00e0 thay \u0111\u1ed5i t\u00e2m tr\u1ea1ng, thu\u1ed1c ch\u1ed1ng n\u00f4n l\u00e0m gi\u1ea3m tri\u1ec7u ch\u1ee9ng bu\u1ed3n n\u00f4n do s\u1eed d\u1ee5ng li\u1ec7u ph\u00e1p hormone<\/li>\n<li>B\u1ed5 sung canxi v\u00e0 vitamin D: Li\u1ec7u ph\u00e1p hormone c\u00f3 th\u1ec3 d\u1eabn \u0111\u1ebfn lo\u00e3ng x\u01b0\u01a1ng, \u0111i\u1ec1u n\u00e0y c\u00f3 th\u1ec3 l\u00e0m t\u0103ng nguy c\u01a1 g\u00e3y x\u01b0\u01a1ng. C\u00f3 th\u1ec3 b\u1ed5 sung canxi v\u00e0 vitamin D, c\u0169ng nh\u01b0 c\u00e1c lo\u1ea1i thu\u1ed1c nh\u01b0 bisphosphonates ho\u1eb7c denosumab \u0111\u1ec3 gi\u00fap duy tr\u00ec s\u1ee9c kh\u1ecfe c\u1ee7a x\u01b0\u01a1ng.<\/li>\n<li>Theo d\u00f5i th\u01b0\u1eddng xuy\u00ean: Theo d\u00f5i th\u01b0\u1eddng xuy\u00ean n\u1ed3ng \u0111\u1ed9 hormone, m\u1eadt \u0111\u1ed9 x\u01b0\u01a1ng v\u00e0 c\u00e1c d\u1ea5u hi\u1ec7u s\u1ee9c kh\u1ecfe kh\u00e1c c\u00f3 th\u1ec3 gi\u00fap x\u00e1c \u0111\u1ecbnh s\u1edbm c\u00e1c t\u00e1c d\u1ee5ng ph\u1ee5 ti\u1ec1m \u1ea9n v\u00e0 cho ph\u00e9p can thi\u1ec7p k\u1ecbp th\u1eddi.<\/li>\n<li>\u0110i\u1ec1u ch\u1ec9nh ph\u01b0\u01a1ng ph\u00e1p \u0111i\u1ec1u tr\u1ecb: Trong m\u1ed9t s\u1ed1 tr\u01b0\u1eddng h\u1ee3p, vi\u1ec7c \u0111i\u1ec1u ch\u1ec9nh lo\u1ea1i ho\u1eb7c li\u1ec1u l\u01b0\u1ee3ng li\u1ec7u ph\u00e1p hormone c\u00f3 th\u1ec3 gi\u00fap gi\u1ea3m b\u1edbt t\u00e1c d\u1ee5ng ph\u1ee5 trong khi v\u1eabn mang l\u1ea1i hi\u1ec7u qu\u1ea3 \u0111i\u1ec1u tr\u1ecb ung th\u01b0 v\u00fa.<\/li>\n<\/ul>\n<h2>K\u1ebft lu\u1eadn<\/h2>\n<p>Vi\u1ec7c l\u1ef1a ch\u1ecdn li\u1ec7u ph\u00e1p hormone ph\u1ee5 thu\u1ed9c v\u00e0o m\u1ed9t s\u1ed1 y\u1ebfu t\u1ed1, bao g\u1ed3m giai \u0111o\u1ea1n ung th\u01b0, ph\u00e2n lo\u1ea1i ung th\u01b0 v\u00fa, t\u00ecnh tr\u1ea1ng m\u00e3n kinh v\u00e0 s\u1ee9c kh\u1ecfe t\u1ed5ng th\u1ec3 c\u1ee7a b\u1ec7nh nh\u00e2n. Li\u1ec7u ph\u00e1p hormone \u0111\u00e3 \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng trong \u0111i\u1ec1u tr\u1ecb ung th\u01b0 v\u00fa h\u01a1n 100 n\u0103m qua v\u00e0 v\u1eabn \u0111ang \u0111\u01b0\u1ee3c nghi\u00ean c\u1ee9u \u0111\u1ec3 c\u1ea3i thi\u1ec7n hi\u1ec7u qu\u1ea3 v\u00e0 \u0111\u1ed9 an to\u00e0n.<\/p>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Ung th\u01b0 v\u00fa l\u00e0 lo\u1ea1i ung th\u01b0 ph\u1ed5 bi\u1ebfn nh\u1ea5t \u1edf ph\u1ee5 n\u1eef tr\u00ean th\u1ebf gi\u1edbi v\u00e0 t\u00e1c \u0111\u1ed9ng \u0111\u00e1ng k\u1ec3 \u0111\u1ebfn s\u1ee9c kh\u1ecfe to\u00e0n c\u1ea7u. Li\u1ec7u ph\u00e1p hormone l\u00e0 m\u1ed9t ph\u01b0\u01a1ng th\u1ee9c \u0111i\u1ec1u tr\u1ecb quan tr\u1ecdng \u0111\u1ed1i v\u1edbi ung th\u01b0 v\u00fa, \u0111\u1eb7c bi\u1ec7t \u0111\u1ed1i v\u1edbi ung th\u01b0 v\u00fa ph\u1ee5 thu\u1ed9c n\u1ed9i ti\u1ebft (HR+). Trong [&hellip;]<\/p>\n","protected":false},"author":61,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[6,33],"tags":[3],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v20.4 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>T\u1ed5ng quan v\u1ec1 li\u1ec7u ph\u00e1p hormone trong \u0111i\u1ec1u tr\u1ecb ung th\u01b0 v\u00fa - Vinmec<\/title>\n<meta name=\"description\" content=\"Trong b\u00e0i vi\u1ebft n\u00e0y, ch\u00fang t\u00f4i s\u1ebd cung c\u1ea5p m\u1ed9t c\u00e1i nh\u00ecn t\u1ed5ng quan v\u1ec1 li\u1ec7u ph\u00e1p hormone trong \u0111i\u1ec1u tr\u1ecb ung th\u01b0 v\u00fa cho c\u00e1c chuy\u00ean gia y t\u1ebf.\" \/>\n<meta name=\"robots\" content=\"noindex, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"T\u1ed5ng quan v\u1ec1 li\u1ec7u ph\u00e1p hormone trong \u0111i\u1ec1u tr\u1ecb ung th\u01b0 v\u00fa - 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