{"id":23008,"date":"2023-04-17T15:21:07","date_gmt":"2023-04-17T08:21:07","guid":{"rendered":"http:\/\/noithathoaphat.in\/ctv\/?p=23008"},"modified":"2023-04-17T16:48:21","modified_gmt":"2023-04-17T09:48:21","slug":"lecanemab-giai-phap-tiem-nang-cho-giai-doan-dau-benh-alzheimer","status":"publish","type":"post","link":"http:\/\/noithathoaphat.in\/ctv\/index.php\/2023\/04\/17\/lecanemab-giai-phap-tiem-nang-cho-giai-doan-dau-benh-alzheimer\/","title":{"rendered":"Lecanemab: gi\u1ea3i ph\u00e1p ti\u1ec1m n\u0103ng cho giai \u0111o\u1ea1n \u0111\u1ea7u b\u1ec7nh Alzheimer"},"content":{"rendered":"

Alzheimer l\u00e0 m\u1ed9t trong nh\u1eefng c\u0103n b\u1ec7nh l\u00fd n\u00e3o ph\u1ed5 bi\u1ebfn v\u00e0 ng\u00e0y c\u00e0ng gia t\u0103ng \u1edf nh\u1eefng ng\u01b0\u1eddi trung ni\u00ean v\u00e0 cao tu\u1ed5i. Hi\u1ec7n nay, vi\u1ec7c \u0111i\u1ec1u tr\u1ecb d\u1ee9t \u0111i\u1ec3m b\u1ec7nh Alzheimer v\u1eabn ch\u01b0a \u0111\u01b0\u1ee3c t\u00ecm th\u1ea5y. Tuy nhi\u00ean, Lecanumab – m\u1ed9t lo\u1ea1i thu\u1ed1c \u0111\u01b0\u1ee3c ph\u00e1t tri\u1ec3n b\u1edfi c\u00f4ng ty th\u1ebf gi\u1edbi Novartis v\u00e0 s\u1ef1 h\u1ee3p t\u00e1c c\u1ee7a c\u00e1c nh\u00e0 khoa h\u1ecdc – \u0111ang \u0111\u01b0\u1ee3c xem l\u00e0 gi\u1ea3i ph\u00e1p ti\u1ec1m n\u0103ng cho giai \u0111o\u1ea1n \u0111\u1ea7u c\u1ee7a b\u1ec7nh Alzheimer. Lecanumab c\u00f3 kh\u1ea3 n\u0103ng lo\u1ea1i b\u1ecf m\u1ea3ng beta-amyloid, m\u1ed9t ch\u1ea5t \u0111\u1ed9c g\u00e2y t\u1ed5n th\u01b0\u01a1ng n\u00e3o v\u00e0 g\u00e2y ra t\u00ecnh tr\u1ea1ng suy gi\u1ea3m nh\u1eadn th\u1ee9c \u1edf b\u1ec7nh Alzheimer. Vi\u1ec7c s\u1eed d\u1ee5ng Lecanumab trong giai \u0111o\u1ea1n s\u1edbm c\u1ee7a b\u1ec7nh Alzheimer \u0111ang nh\u1eadn \u0111\u01b0\u1ee3c s\u1ef1 quan t\u00e2m v\u00e0 hy v\u1ecdng s\u1ebd \u0111em l\u1ea1i nh\u1eefng k\u1ebft qu\u1ea3 t\u00edch c\u1ef1c trong vi\u1ec7c \u0111i\u1ec1u tr\u1ecb v\u00e0 ng\u0103n ng\u1eeba b\u1ec7nh ph\u00e1t tri\u1ec3n.<\/strong><\/p>\n

1.T\u1ed5ng quan v\u1ec1 Alzheimer (AD)<\/strong><\/h2>\n

1.1 B\u1ec7nh Alzheimer l\u00e0 g\u00ec?<\/span><\/h3>\n

B\u1ec7nh l\u00fd Alzheimer<\/a> l\u00e0 d\u1ea1ng ph\u1ed5 bi\u1ebfn nh\u1ea5t c\u1ee7a nh\u00f3m b\u1ec7nh sa s\u00fat tr\u00ed tu\u1ec7. B\u1ec7nh \u0111\u01b0\u1ee3c b\u1eaft \u0111\u1ea7u t\u1eeb v\u1edbi tri\u1ec7u ch\u1ee9ng m\u1ea5t tr\u00ed nh\u1edb nh\u1eb9 v\u00e0 d\u1ea7n chuy\u1ec3n bi\u1ebfn n\u1eb7ng v\u1edbi t\u00ecnh tr\u1ea1ng m\u1ea5t kh\u1ea3 n\u0103ng n\u00f3i chuy\u1ec7n v\u00e0 ho\u1ea1t \u0111\u1ed9ng \u0111\u00e1p \u1ee9ng v\u1edbi m\u00f4i tr\u01b0\u1eddng s\u1ed1ng v\u00ec b\u1ec7nh bao g\u1ed3m nh\u1eefng ph\u1ea7n quan tr\u1ecdng c\u1ee7a n\u00e3o trong vai tr\u00f2 \u0111i\u1ec1u khi\u1ec3n suy ngh\u0129, tr\u00ed nh\u1edb, ng\u00f4n ng\u1eef. B\u1ec7nh Alzheimer giai \u0111o\u1ea1n n\u1eb7ng \u1ea3nh h\u01b0\u1edfng n\u1eb7ng n\u1ec1 \u0111\u1ebfn kh\u1ea3 n\u0103ng sinh ho\u1ea1t h\u1eb1ng ng\u00e0y ng\u00e0y c\u1ee7a b\u1ec7nh nh\u00e2n. B\u1ec7nh Alzheimer th\u01b0\u1eddng x\u1ea3y ra \u1edf b\u1ec7nh nh\u00e2n c\u00f3 \u0111\u1ed9 tu\u1ed5i tr\u00ean 65, c\u00e1c \u0111\u1ed1i t\u01b0\u1ee3ng c\u00f3 r\u1ed1i lo\u1ea1n n\u00e3o b\u1ea9m sinh ho\u1eb7c b\u1ecb ch\u1ea5n th\u01b0\u01a1ng v\u00e0 th\u1eadm ch\u00ed l\u00e0 m\u1ed9t ph\u1ea7n gi\u1edbi tr\u1ebb c\u0169ng b\u1ecb \u0111e d\u1ecda b\u1edfi b\u1ec7nh n\u00e0y.\u00a0\u00a0<\/span><\/p>\n

\"B\u1ec7nh
B\u1ec7nh Alzheimer<\/figcaption><\/figure>\n

1.2 D\u1ea5u hi\u1ec7u c\u1ea3nh b\u00e1o c\u1ee7a Alzheimer?<\/span><\/h3>\n

B\u1ec7nh l\u00fd Alzheimer kh\u00f4ng thu\u1ed9c qu\u00e1 tr\u00ecnh l\u00e3o h\u00f3a b\u00ecnh th\u01b0\u1eddng. C\u00e1c v\u1ea5n \u0111\u1ec1 v\u1ec1 tr\u00ed nh\u1edb l\u00e0 m\u1ed9t trong nh\u1eefng c\u1ea3nh b\u00e1o \u0111i\u1ec3n h\u00ecnh c\u1ee7a b\u1ec7nh v\u00e0 nh\u1eefng d\u1ea5u hi\u1ec7u li\u00ean quan \u0111\u1ebfn sa s\u00fat tr\u00ed tu\u1ec7 bao g\u1ed3m: m\u1ea5t tr\u00ed nh\u1edb ch\u1eb3ng h\u1ea1n nh\u01b0 b\u1ecb l\u1ea1c \u1edf n\u01a1i quen thu\u1ed9c ho\u1eb7c l\u1eb7p \u0111i l\u1eb7p l\u1ea1i c\u00f9ng c\u00e2u h\u1ecfi, g\u1eb7p r\u1eafc r\u1ed1i khi thanh to\u00e1n h\u00f3a \u0111\u01a1n, kh\u00f3 th\u1ef1c hi\u1ec7n c\u00e1c ho\u1ea1t \u0111\u1ed9ng quen thu\u1ed9c t\u1ea1i nh\u00e0, t\u1ea1i n\u01a1i l\u00e0m vi\u1ec7c ho\u1eb7c l\u00fac r\u1ea3nh, th\u01b0\u1eddng xuy\u00ean nh\u1ea7m l\u1eabn v\u1ecb tr\u00ed \u0111\u1ed3 v\u1eadt, thay \u0111\u1ed5i t\u00e2m tr\u1ea1ng h\u00e0nh vi. Khi xu\u1ea5t hi\u1ec7n m\u1ed9t s\u1ed1 ho\u1eb7c th\u1eadm ch\u00ed to\u00e0n b\u1ed9 c\u00e1c d\u1ea5u hi\u1ec7u n\u00e0y \u0111\u1ed3ng ngh\u0129a nguy c\u01a1 m\u1eafc b\u1ec7nh t\u0103ng cao<\/span><\/p>\n

1.3 Nguy\u00ean nh\u00e2n \u2013 y\u1ebfu t\u1ed1 r\u1ee7i ro g\u00e2y b\u1ec7nh Alzheimer?<\/span><\/h3>\n

M\u1eb7c d\u00f9 ch\u01b0a c\u00f3 nhi\u1ec1u nghi\u00ean c\u1ee9u \u0111\u01b0a ra \u0111\u1ea7y \u0111\u1ee7 nguy\u00ean nh\u00e2n g\u00e2y b\u1ec7nh nh\u01b0ng nhi\u1ec1u kh\u1ea3 n\u0103ng kh\u00f4ng ph\u1ea3i l\u00e0 m\u1ed9t nguy\u00ean nh\u00e2n duy nh\u1ea5t m\u00e0 l\u00e0 m\u1ed9t s\u1ed1 y\u1ebfu t\u1ed1 c\u00f3 th\u1ec3 \u1ea3nh h\u01b0\u1edfng kh\u00e1c nhau \u0111\u1ebfn m\u1ed7i ng\u01b0\u1eddi<\/span><\/p>\n

    \n
  • Tu\u1ed5i t\u00e1c l\u00e0 y\u1ebfu t\u1ed1 r\u1ee7i ro \u0111\u01b0\u1ee3c bi\u1ebft \u0111\u1ebfn nhi\u1ec1u nh\u1ea5t \u0111\u1ed1i v\u1edbi b\u1ec7nh Alzheimer<\/span><\/li>\n
  • Ti\u1ec1n s\u1eed gia \u0111\u00ecnh: c\u00e1c nh\u00e0 nghi\u00ean c\u1ee9u tin r\u1eb1ng di truy\u1ec1n h\u1ecdc c\u00f3 th\u1ec3 \u0111\u00f3ng m\u1ed9t vai tr\u00f2 trong vi\u1ec7c ph\u00e1t tri\u1ec3n b\u1ec7nh Alzheimer. Tuy nhi\u00ean, m\u1ed9t l\u1ed1i s\u1ed1ng l\u00e0nh m\u1ea1nh c\u00f3 th\u1ec3 gi\u00fap gi\u1ea3m nguy c\u01a1 ph\u00e1t tri\u1ec3n b\u1ec7nh Alzheimer<\/span><\/li>\n
  • Nh\u1eefng thay \u0111\u1ed5i trong n\u00e3o c\u00f3 th\u1ec3 b\u1eaft \u0111\u1ea7u nhi\u1ec1u n\u0103m tr\u01b0\u1edbc khi c\u00e1c tri\u1ec7u ch\u1ee9ng \u0111\u1ea7u ti\u00ean xu\u1ea5t hi\u1ec7n<\/span><\/li>\n<\/ul>\n

    1.4 Ph\u01b0\u01a1ng c\u00e1ch \u0111i\u1ec1u tr\u1ecb b\u1ec7nh?<\/span><\/h3>\n

    B\u1ec7nh Alzheimer r\u1ea5t ph\u1ee9c t\u1ea1p v\u00e0 kh\u00f4ng ch\u1eafc r\u1eb1ng b\u1ea5t k\u1ef3 lo\u1ea1i thu\u1ed1c ho\u1eb7c bi\u1ec7n ph\u00e1p can thi\u1ec7p n\u00e0o kh\u00e1c s\u1ebd \u0111i\u1ec1u tr\u1ecb th\u00e0nh c\u00f4ng b\u1ec7nh n\u00e0y \u1edf t\u1ea5t c\u1ea3 nh\u1eefng ng\u01b0\u1eddi m\u1eafc b\u1ec7nh. Tuy nhi\u00ean, trong nh\u1eefng n\u0103m g\u1ea7n \u0111\u00e2y, c\u00e1c nh\u00e0 khoa h\u1ecdc \u0111\u00e3 \u0111\u1ea1t \u0111\u01b0\u1ee3c nh\u1eefng ti\u1ebfn b\u1ed9 to l\u1edbn trong vi\u1ec7c hi\u1ec3u r\u00f5 h\u01a1n v\u1ec1 b\u1ec7nh Alzheimer c\u0169ng nh\u01b0 trong vi\u1ec7c ph\u00e1t tri\u1ec3n v\u00e0 th\u1eed nghi\u1ec7m c\u00e1c ph\u01b0\u01a1ng ph\u00e1p \u0111i\u1ec1u tr\u1ecb m\u1edbi. M\u1ed9t s\u1ed1 lo\u1ea1i thu\u1ed1c theo toa \u0111\u00e3 \u0111\u01b0\u1ee3c C\u1ee5c Qu\u1ea3n l\u00fd Th\u1ef1c ph\u1ea9m v\u00e0 D\u01b0\u1ee3c ph\u1ea9m Hoa K\u1ef3 (FDA) ph\u00ea duy\u1ec7t \u0111\u1ec3 gi\u00fap ki\u1ec3m so\u00e1t c\u00e1c tri\u1ec7u ch\u1ee9ng \u1edf nh\u1eefng ng\u01b0\u1eddi m\u1eafc b\u1ec7nh Alzheimer v\u00e0 c\u00e1c lo\u1ea1i thu\u1ed1c kh\u00e1c g\u1ea7n \u0111\u00e2y \u0111\u00e3 xu\u1ea5t hi\u1ec7n \u0111\u1ec3 \u0111i\u1ec1u tr\u1ecb s\u1ef1 ti\u1ebfn tri\u1ec3n c\u1ee7a b\u1ec7nh.H\u1ea7u h\u1ebft c\u00e1c lo\u1ea1i thu\u1ed1c \u0111\u01b0\u1ee3c FDA ph\u00ea chu\u1ea9n \u0111\u1ec1u c\u00f3 t\u00e1c d\u1ee5ng t\u1ed1t nh\u1ea5t \u0111\u1ed1i v\u1edbi nh\u1eefng ng\u01b0\u1eddi \u1edf giai \u0111o\u1ea1n \u0111\u1ea7u ho\u1eb7c gi\u1eefa c\u1ee7a b\u1ec7nh Alzheimer. Hi\u1ec7n t\u1ea1i kh\u00f4ng c\u00f3 bi\u1ec7n ph\u00e1p can thi\u1ec7p n\u00e0o \u0111\u01b0\u1ee3c bi\u1ebft s\u1ebd ch\u1eefa kh\u1ecfi b\u1ec7nh Alzheimer. Galantamine, Rivastigmine v\u00e0 Donepezil l\u00e0 nh\u1eefng ch\u1ea5t \u1ee9c ch\u1ebf cholinesterase \u0111\u01b0\u1ee3c k\u00ea \u0111\u01a1n cho c\u00e1c tri\u1ec7u ch\u1ee9ng b\u1ec7nh Alzheimer nh\u1eb9 \u0111\u1ebfn trung b\u00ecnh. Nh\u1eefng lo\u1ea1i thu\u1ed1c n\u00e0y c\u00f3 th\u1ec3 gi\u00fap l\u00e0m gi\u1ea3m ho\u1eb7c ki\u1ec3m so\u00e1t m\u1ed9t s\u1ed1 tri\u1ec7u ch\u1ee9ng v\u1ec1 nh\u1eadn th\u1ee9c v\u00e0 h\u00e0nh vi .C\u00e1c ch\u1ea5t \u1ee9c ch\u1ebf men cholinesterase ng\u0103n ch\u1eb7n s\u1ef1 ph\u00e2n h\u1ee7y Acetylcholine, m\u1ed9t ch\u1ea5t h\u00f3a h\u1ecdc trong n\u00e3o \u0111\u01b0\u1ee3c cho l\u00e0 quan tr\u1ecdng \u0111\u1ed1i v\u1edbi tr\u00ed nh\u1edb v\u00e0 t\u01b0 duy. Khi b\u1ec7nh Alzheimer ti\u1ebfn tri\u1ec3n, n\u00e3o s\u1ea3n xu\u1ea5t \u00edt acetylcholine h\u01a1n v\u00e0 theo th\u1eddi gian, nh\u1eefng lo\u1ea1i thu\u1ed1c n\u00e0y cu\u1ed1i c\u00f9ng s\u1ebd m\u1ea5t t\u00e1c d\u1ee5ng. V\u00ec c\u00e1c ch\u1ea5t \u1ee9c ch\u1ebf cholinesterase ho\u1ea1t \u0111\u1ed9ng theo c\u00e1ch t\u01b0\u01a1ng t\u1ef1, n\u00ean vi\u1ec7c chuy\u1ec3n t\u1eeb lo\u1ea1i n\u00e0y sang lo\u1ea1i kh\u00e1c c\u00f3 th\u1ec3 kh\u00f4ng t\u1ea1o ra k\u1ebft qu\u1ea3 kh\u00e1c bi\u1ec7t \u0111\u00e1ng k\u1ec3, nh\u01b0ng m\u1ed9t ng\u01b0\u1eddi m\u1eafc b\u1ec7nh Alzheimer c\u00f3 th\u1ec3 \u0111\u00e1p \u1ee9ng t\u1ed1t h\u01a1n v\u1edbi lo\u1ea1i thu\u1ed1c n\u00e0y so v\u1edbi lo\u1ea1i thu\u1ed1c kh\u00e1c. Aducanumab l\u00e0 li\u1ec7u ph\u00e1p mi\u1ec5n d\u1ecbch \u0111\u01b0\u1ee3c FDA ph\u00ea duy\u1ec7t nhanh \u0111\u1ec3 \u0111i\u1ec1u tr\u1ecb b\u1ec7nh Alzheimer giai \u0111o\u1ea1n \u0111\u1ea7u. Leqembi, c\u00f2n \u0111\u01b0\u1ee3c g\u1ecdi l\u00e0 Lecanemab-irmb, l\u00e0 m\u1ed9t ph\u01b0\u01a1ng ph\u00e1p \u0111i\u1ec1u tr\u1ecb m\u1edbi cho b\u1ec7nh Alzheimer k\u1ec3 t\u1eeb ng\u00e0y 6 th\u00e1ng 1 n\u0103m 2023, \u0111\u00e3 \u0111\u01b0\u1ee3c C\u1ee5c Qu\u1ea3n l\u00fd Th\u1ef1c ph\u1ea9m v\u00e0 D\u01b0\u1ee3c ph\u1ea9m Hoa K\u1ef3 (FDA) ph\u00ea duy\u1ec7t th\u00f4ng qua l\u1ed9 tr\u00ecnh Ph\u00ea duy\u1ec7t Nhanh. Ph\u01b0\u01a1ng ph\u00e1p \u0111i\u1ec1u tr\u1ecb m\u1edbi n\u00e0y th\u1ec3 hi\u1ec7n m\u1ed9t b\u01b0\u1edbc ti\u1ebfn quan tr\u1ecdng trong cu\u1ed9c chi\u1ebfn ch\u1ed1ng l\u1ea1i b\u1ec7nh Alzheimer \u0111ang di\u1ec5n ra, v\u00ec n\u00f3 nh\u1eafm v\u00e0o sinh l\u00fd b\u1ec7nh c\u01a1 b\u1ea3n c\u1ee7a b\u1ec7nh, thay v\u00ec ch\u1ec9 \u0111i\u1ec1u tr\u1ecb c\u00e1c tri\u1ec7u ch\u1ee9ng c\u1ee7a n\u00f3.<\/span><\/p>\n

    2.T\u1ed5ng quan v\u1ec1 thu\u1ed1c Lecanemab<\/strong><\/h2>\n

    2.1 Gi\u1edbi thi\u1ec7u v\u00e0 ch\u1ec9 \u0111\u1ecbnh s\u1eed d\u1ee5ng thu\u1ed1c Lecanemab<\/span><\/h3>\n

    Lecanemab l\u00e0 m\u1ed9t li\u1ec7u ph\u00e1p kh\u00e1ng th\u1ec3 m\u1edbi \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng \u0111i\u1ec1u tr\u1ecb b\u1ec7nh Alzheimer \u1edf nh\u1eefng b\u1ec7nh nh\u00e2n b\u1ecb suy gi\u1ea3m nh\u1eadn th\u1ee9c nh\u1eb9 ho\u1eb7c sa s\u00fat tr\u00ed tu\u1ec7 nh\u1eb9 trong giai \u0111o\u1ea1n \u0111\u1ea7u. Lecanemab l\u00e0 kh\u00e1ng th\u1ec3 \u0111\u01a1n d\u00f2ng globulin mi\u1ec5n d\u1ecbch gamma 1 (IgG1) t\u00e1i t\u1ed5 h\u1ee3p \u0111\u01b0\u1ee3c nh\u00e2n h\u00f3a tr\u1ef1c ti\u1ebfp ch\u1ed1ng l\u1ea1i c\u00e1c d\u1ea1ng amyloid beta (A\u03b2) h\u00f2a tan v\u00e0 kh\u00f4ng h\u00f2a tan t\u1ed5ng h\u1ee3p, c\u00f3 li\u00ean quan \u0111\u1ebfn sinh l\u00fd b\u1ec7nh c\u1ee7a b\u1ec7nh Alzheimer<\/span><\/p>\n

    \"Lecanemab\"
    Lecanemab<\/figcaption><\/figure>\n

    2.2 C\u01a1 ch\u1ebf ho\u1ea1t \u0111\u1ed9ng c\u1ee7a Lecanemab<\/span><\/h3>\n

    C\u00e1c m\u1ea3ng amyloid-\u03b2 (A\u03b2) ngo\u1ea1i b\u00e0o l\u00e0 m\u1ed9t d\u1ea5u hi\u1ec7u \u0111\u1eb7c tr\u01b0ng c\u1ee7a b\u1ec7nh Alzheimer (AD), khi\u1ebfn ch\u00fang tr\u1edf th\u00e0nh m\u1ee5c ti\u00eau \u0111i\u1ec1u tr\u1ecb mong mu\u1ed1n cho c\u00e1c lo\u1ea1i thu\u1ed1c ti\u1ec1m n\u0103ng \u0111\u1ec3 \u0111i\u1ec1u tr\u1ecb AD. Vi\u1ec7c s\u1ea3n xu\u1ea5t v\u00e0 t\u00edch t\u1ee5 c\u00e1c m\u1ea3ng A\u03b2 trong n\u00e3o th\u01b0\u1eddng \u0111\u01b0\u1ee3c quan s\u00e1t th\u1ea5y \u1edf AD v\u00e0 c\u00e1c \u0111\u1eb7c \u0111i\u1ec3m ri\u00eang bi\u1ec7t c\u1ee7a c\u00e1c m\u1ea3ng A\u03b2, ch\u1eb3ng h\u1ea1n nh\u01b0 \u0111\u1ed9 h\u00f2a tan, s\u1ed1 l\u01b0\u1ee3ng v\u00e0 th\u00e0nh ph\u1ea7n c\u1ee7a c\u00e1c nh\u00f3m A\u03b2 – c\u00f3 th\u1ec3 \u1ea3nh h\u01b0\u1edfng \u0111\u1ebfn t\u00ecnh tr\u1ea1ng b\u1ec7nh. A\u03b2 g\u00e2y suy gi\u1ea3m kh\u1edbp th\u1ea7n kinh, ch\u1ebft t\u1ebf b\u00e0o th\u1ea7n kinh v\u00e0 tho\u00e1i h\u00f3a th\u1ea7n kinh ti\u1ebfn tri\u1ec3n, d\u1eabn \u0111\u1ebfn ch\u1ee9ng m\u1ea5t tr\u00ed nh\u1edb v\u00e0 suy gi\u1ea3m nh\u1eadn th\u1ee9c li\u00ean quan \u0111\u1ebfn AD. A\u03b2 peptide t\u1ed3n t\u1ea1i \u1edf c\u00e1c tr\u1ea1ng th\u00e1i h\u00ecnh d\u1ea1ng kh\u00e1c nhau, bao g\u1ed3m c\u00e1c monome h\u00f2a tan, c\u00e1c t\u1eadp h\u1ee3p h\u00f2a tan c\u00f3 k\u00edch th\u01b0\u1edbc t\u0103ng d\u1ea7n, c\u00e1c s\u1ee3i v\u00e0 m\u1ea3ng b\u00e1m kh\u00f4ng h\u00f2a tan. C\u00e1c t\u1eadp h\u1ee3p A\u03b2 h\u00f2a tan nh\u01b0 A\u03b2 protofibrils g\u00e2y \u0111\u1ed9c th\u1ea7n kinh h\u01a1n so v\u1edbi c\u00e1c monome ho\u1eb7c fibrils kh\u00f4ng h\u00f2a tan. Lecanemab l\u00e0 m\u1ed9t kh\u00e1ng th\u1ec3 l\u00e0m gi\u1ea3m c\u00e1c m\u1ea3ng A\u03b2 trong n\u00e3o, \u01b0u ti\u00ean nh\u1eafm m\u1ee5c ti\u00eau v\u00e0o c\u00e1c m\u1ea3ng A\u03b2 t\u1ed5ng h\u1ee3p h\u00f2a tan v\u00e0 ho\u1ea1t \u0111\u1ed9ng tr\u00ean A\u03b2 oligomers, protofibrils v\u00e0 fibrils kh\u00f4ng h\u00f2a tan. C\u1ee5 th\u1ec3, Lecanemab l\u00e0m gi\u1ea3m m\u1ea3ng b\u00e1m beta-amyloid t ph\u1ee5 thu\u1ed9c v\u00e0o li\u1ec1u l\u01b0\u1ee3ng v\u00e0 th\u1eddi gian v\u00e0 t\u00e1c d\u1ee5ng c\u1ee7a thu\u1ed1c \u0111\u1ed1i v\u1edbi m\u1ee9c \u0111\u1ed9 m\u1ea3ng b\u00e1m beta amyloid trong n\u00e3o \u0111\u01b0\u1ee3c \u0111\u00e1nh gi\u00e1 b\u1eb1ng c\u00e1ch s\u1eed d\u1ee5ng h\u00ecnh \u1ea3nh PET (ch\u1ea5t \u0111\u00e1nh d\u1ea5u 18F-Florbetapir) \u2013 \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng \u0111\u1ec3 x\u00e1c \u0111\u1ecbnh m\u1ee9c Amyloid hi\u1ec7n di\u1ec7n trong n\u00e3o. Nghi\u00ean c\u1ee9u cho th\u1ea5y \u0111i\u1ec1u tr\u1ecb b\u1eb1ng Lecanemab li\u1ec1u 10 mg\/kg m\u1ed7i hai tu\u1ea7n l\u00e0m gi\u1ea3m m\u1ee9c \u0111\u1ed9 m\u1ea3ng b\u00e1m beta-amyloid\u00a0 trong n\u00e3o v\u00e0 l\u00e0m gi\u1ea3m PET. Ngo\u00e0i ra, khi \u0111\u01b0\u1ee3c \u0111i\u1ec1u tr\u1ecb v\u1edbi Lecanemab, n\u1ed3ng \u0111\u1ed9 p-tau181 trong huy\u1ebft t\u01b0\u01a1ng gi\u1ea3m \u0111\u01b0\u1ee3c cho l\u00e0 y\u1ebfu t\u1ed1 d\u1ef1 b\u00e1o quan tr\u1ecdng l\u00e0m ch\u1eadm qu\u00e1 tr\u00ecnh suy gi\u1ea3m nh\u1eadn th\u1ee9c<\/span><\/p>\n

    \"C\u01a1
    C\u01a1 ch\u1ebf ho\u1ea1t \u0111\u1ed9ng c\u1ee7a Lecanemab<\/figcaption><\/figure>\n

    2.3 Li\u1ec1u l\u01b0\u1ee3ng c\u1ee7a Lecanemab trong \u0111i\u1ec1u tr\u1ecb b\u1ec7nh Alzheimer<\/span><\/h3>\n

    Li\u1ec1u l\u01b0\u1ee3ng khuy\u1ebfn ngh\u1ecb l\u00e0 10 mg\/kg, sau \u0111\u00f3 ph\u1ea3i pha lo\u00e3ng d\u00f9ng d\u01b0\u1edbi d\u1ea1ng truy\u1ec1n t\u0129nh m\u1ea1ch trong kho\u1ea3ng m\u1ed9t gi\u1edd v\u00e0 s\u1eed d\u1ee5ng 2 tu\u1ea7n \/ l\u1ea7n<\/span><\/p>\n

    2.4 Th\u1eadn tr\u1ecdng khi s\u1eed d\u1ee5ng Lecanemab trong \u0111i\u1ec1u tr\u1ecb Alzheimer<\/span><\/h3>\n

    C\u00e1c b\u1ea5t th\u01b0\u1eddng v\u1ec1 h\u00ecnh \u1ea3nh li\u00ean quan \u0111\u1ebfn Amyloid (ARIA): khi s\u1eed d\u1ee5ng Lecanemab c\u00f3 th\u1ec3 g\u00e2y ra c\u00e1c b\u1ea5t th\u01b0\u1eddng v\u1ec1 h\u00ecnh \u1ea3nh c\u1ee7a Amyloid k\u00e8m theo ph\u00f9 n\u1ec1 (ARIA-E) nh\u01b0 quan s\u00e1t tr\u00ean MRI ph\u00e1t hi\u1ec7n t\u00ecnh tr\u1ea1ng ph\u00f9 n\u00e3o, tr\u00e0n d\u1ecbch v\u00f9ng r\u00e3nh v\u00e0 ARIA v\u1edbi l\u1eafng \u0111\u1ecdng Hemosiderin (ARIA-H) bao g\u1ed3m xu\u1ea5t huy\u1ebft vi m\u00f4 v\u00e0 nhi\u1ec5m \u0111\u1ed9c siderosis tr\u00ean b\u1ec1n m\u1eb7t. ARIA-H c\u00f3 th\u1ec3 x\u1ea3y ra t\u1ef1 ph\u00e1t \u1edf b\u1ec7nh nh\u00e2n m\u1eafc b\u1ec7nh Alzheimer v\u00e0 c\u00f3 th\u1ec3 x\u1ea3y ra c\u00f9ng l\u00fac v\u1edbi ARIA-E. ARIA th\u01b0\u1eddng kh\u00f4ng c\u00f3 tri\u1ec7u ch\u1ee9ng m\u1eb7c d\u00f9 t\u00ednh nghi\u00eam tr\u1ecdng c\u00f3 th\u1ec3 \u0111e d\u1ecda t\u00ednh m\u1ea1ng khi x\u1ea3y ra t\u00ecnh tr\u1ea1ng co gi\u1eadt, tr\u1ea1ng th\u00e1i \u0111\u1ed9ng kinh.T\u1ec9 l\u1ec7 m\u1eafc ARIA: ARIA c\u00f3 tri\u1ec7u ch\u1ee9ng x\u1ea3y ra \u1edf 3% (5\/161) b\u1ec7nh nh\u00e2n \u0111\u01b0\u1ee3c \u0111i\u1ec1u tr\u1ecb b\u1eb1ng Lecanemab v\u00e0 c\u00e1c tri\u1ec7u ch\u1ee9ng l\u00e2m s\u00e0ng li\u00ean quan \u0111\u1ebfn ARIA \u0111\u00e3 \u0111\u01b0\u1ee3c \u0111i\u1ec1u tr\u1ecb \u1edf 80% b\u1ec7nh nh\u00e2n. ARIA kh\u00f4ng tri\u1ec7u ch\u1ee9ng \u0111\u01b0\u1ee3c ph\u00e1t hi\u1ec7n b\u1eb1ng X-quang \u0111\u01b0\u1ee3c t\u00ecm th\u1ea5y \u1edf 12% b\u1ec7nh nh\u00e2n \u0111\u01b0\u1ee3c \u0111i\u1ec1u tr\u1ecb b\u1eb1ng Lecanemab. ARIA-E \u0111\u01b0\u1ee3c quan s\u00e1t th\u1ea5y \u1edf 10% b\u1ec7nh nh\u00e2n d\u00f9ng Lecanemab v\u1edbi 1% d\u00f9ng gi\u1ea3 d\u01b0\u1ee3c.\u00a0 ARIA-H \u0111\u01b0\u1ee3c quan s\u00e1t th\u1ea5y \u1edf 6% b\u1ec7nh nh\u00e2n \u0111\u01b0\u1ee3c \u0111i\u1ec1u tr\u1ecb v\u1edbi Lecanemab so v\u1edbi 5% d\u00f9ng gi\u1ea3 d\u01b0\u1ee3c. N\u00ean t\u0103ng c\u01b0\u1eddng c\u1ea3nh gi\u00e1c l\u00e2m s\u00e0ng \u0111\u1ed1i v\u1edbi ARIA trong 14 tu\u1ea7n \u0111\u1ea7u \u0111i\u1ec1u tr\u1ecb b\u1eb1ng Lecanemab. N\u1ebfu m\u1ed9t b\u1ec7nh nh\u00e2n c\u00f3 c\u00e1c tri\u1ec7u ch\u1ee9ng g\u1ee3i \u00fd ARIA, n\u00ean th\u1ef1c hi\u1ec7n \u0111\u00e1nh gi\u00e1 l\u00e2m s\u00e0ng, bao g\u1ed3m ch\u1ee5p MRI n\u1ebfu \u0111\u01b0\u1ee3c ch\u1ec9 \u0111\u1ecbnh<\/span><\/p>\n

    \"ARIA-E\"
    ARIA<\/figcaption><\/figure>\n

    C\u00e1c ph\u1ea3n \u1ee9ng li\u00ean quan \u0111\u1ebfn truy\u1ec1n d\u1ecbch: C\u00e1c ph\u1ea3n \u1ee9ng li\u00ean quan \u0111\u1ebfn truy\u1ec1n d\u1ecbch x\u1ea3y ra\u00a0 \u1edf m\u1ee9c \u0111\u1ed9 nh\u1eb9 (chi\u1ebfm 56%) ho\u1eb7c trung b\u00ecnh (chi\u1ebfm 44%). C\u00e1c tri\u1ec7u ch\u1ee9ng c\u1ee7a ph\u1ea3n \u1ee9ng li\u00ean quan \u0111\u1ebfn truy\u1ec1n d\u1ecbch bao g\u1ed3m s\u1ed1t v\u00e0 c\u00e1c tri\u1ec7u ch\u1ee9ng gi\u1ed1ng c\u00fam (\u1edbn l\u1ea1nh, \u0111au nh\u1ee9c to\u00e0n th\u00e2n, c\u1ea3m gi\u00e1c run v\u00e0 \u0111au kh\u1edbp), bu\u1ed3n n\u00f4n, n\u00f4n, h\u1ea1 huy\u1ebft \u00e1p, t\u0103ng huy\u1ebft \u00e1p v\u00e0 gi\u1ea3m b\u00e3o h\u00f2a oxy. Trong tr\u01b0\u1eddng h\u1ee3p x\u1ea3y ra ph\u1ea3n \u1ee9ng li\u00ean quan \u0111\u1ebfn truy\u1ec1n d\u1ecbch, c\u00f3 th\u1ec3 gi\u1ea3m t\u1ed1c \u0111\u1ed9 truy\u1ec1n ho\u1eb7c ng\u1eebng truy\u1ec1n v\u00e0 \u00e1p d\u1ee5ng li\u1ec7u ph\u00e1p th\u00edch h\u1ee3p theo ch\u1ec9 \u0111\u1ecbnh l\u00e2m s\u00e0ng<\/span><\/p>\n

    3.\u0110i\u1ec3m gi\u1ed1ng v\u00e0 kh\u00e1c gi\u1eefa Lecanemab v\u00e0 Aducanumab trong Alzheimer<\/strong><\/h2>\n

    Aducanumab v\u00e0 Lecanemab \u0111\u1ec1u l\u00e0 thu\u1ed1c \u0111i\u1ec1u tr\u1ecb b\u1ec7nh Alzheimer \u1edf giai \u0111o\u1ea1n s\u1edbm. Aducanumba l\u00e0 li\u1ec7u ph\u00e1p kh\u00e1ng th\u1ec3 \u0111\u01a1n d\u00f2ng t\u00e1c \u0111\u1ed9ng nh\u1eb1m lo\u1ea1i b\u1ecf beta-amyloid trong n\u00e3o trong khi \u0111\u00f3 Lecanemab ho\u1ea1t \u0111\u1ed9ng b\u1eb1ng c\u00e1ch ng\u0103n ch\u1eb7n s\u1ef1 h\u00ecnh th\u00e0nh c\u00e1c m\u1ea3ng amyloid trong n\u00e3o. Trong c\u00e1c th\u1eed nghi\u1ec7m l\u00e2m s\u00e0ng, Lecanemab \u0111\u00e3 \u0111\u01b0\u1ee3c ch\u1ee9ng minh l\u00e0 lo\u1ea1i b\u1ecf amyloid nhanh h\u01a1n Aducanumab. Lecanemab c\u0169ng cho th\u1ea5y t\u1ef7 l\u1ec7 m\u1eafc t\u00e1c d\u1ee5ng ph\u1ee5 g\u1ecdi l\u00e0 ARIA th\u1ea5p h\u01a1n so v\u1edbi Aducanumab trong c\u00e1c nghi\u00ean c\u1ee9u l\u00e2m s\u00e0ng. C\u1ea3 Aducanumab v\u00e0 Lecanemab \u0111\u1ec1u l\u00e0 m\u1ed9t ph\u1ea7n c\u1ee7a nh\u00f3m nghi\u00ean c\u1ee9u \u0111ang ph\u00e1t tri\u1ec3n v\u1ec1 c\u00e1c ph\u01b0\u01a1ng ph\u00e1p \u0111i\u1ec1u tr\u1ecb m\u1edbi cho b\u1ec7nh Alzheimer v\u00e0 c\u1ea3 hai lo\u1ea1i thu\u1ed1c \u0111\u1ec1u h\u1ee9a h\u1eb9n v\u1ec1 kh\u1ea3 n\u0103ng t\u00e1c \u0111\u1ed9ng tr\u00ean m\u1ee5c ti\u00eau beta-amyloid trong c\u1ea3i thi\u1ec7n sa s\u00fat tr\u00ed tu\u1ec7 nh\u1eb9<\/span><\/p>\n

    4.C\u00e1c nghi\u00ean c\u1ee9u v\u1ec1 hi\u1ec7u qu\u1ea3 \u0111i\u1ec1u tr\u1ecb c\u1ee7a Lecanemab trong giai \u0111o\u1ea1n \u0111\u1ea7u b\u1ec7nh Alzheimer<\/strong><\/h2>\n

    Nghi\u00ean c\u1ee9u c\u1ee7a nh\u00f3m t\u00e1c gi\u1ea3 Christopher H van Dyck v\u00e0o n\u0103m 2023 tr\u00ean 1795 \u0111\u1ed1i t\u01b0\u1ee3ng c\u00f3 \u0111\u1ed9 tu\u1ed5i t\u1eeb 50-90 \u0111ang m\u1eafc \u1edf giai \u0111o\u1ea1n \u0111\u1ea7u c\u1ee7a b\u1ec7nh v\u1edbi ph\u00e1t hi\u1ec7n v\u1ec1 Amyloid \u0111\u01b0\u1ee3c \u0111\u00e1nh gi\u00e1 b\u1eb1ng h\u00ecnh PET ho\u1eb7c x\u00e9t nghi\u1ec7m n\u00e3o t\u1ee7y \u0111\u01b0\u1ee3c ch\u1ec9 \u0111\u1ecbnh Lecanemab ti\u00eam t\u0129nh m\u1ea1ch ho\u1eb7c gi\u1ea3 d\u01b0\u1ee3c. K\u1ebft qu\u1ea3 cho th\u1ea5y Lecanemab l\u00e0m gi\u1ea3m c\u00e1c d\u1ea5u hi\u1ec7u c\u1ee7a amyloid trong b\u1ec7nh Alzheimer giai \u0111o\u1ea1n \u0111\u1ea7u v\u00e0 d\u1eabn \u0111\u1ebfn s\u1ef1 suy gi\u1ea3m nh\u1eadn th\u1ee9c v\u00e0 ch\u1ee9c n\u0103ng \u00edt h\u01a1n \u1edf m\u1ee9c \u0111\u1ed9 v\u1eeba ph\u1ea3i so v\u1edbi gi\u1ea3 d\u01b0\u1ee3c sau 18 th\u00e1ng nh\u01b0ng c\u00f3 li\u00ean quan \u0111\u1ebfn c\u00e1c t\u00e1c d\u1ee5ng ph\u1ee5<\/span><\/p>\n

    T\u00e1c gi\u1ea3 Eric McDade c\u00f9ng c\u1ed9ng s\u1ef1 th\u1ef1c hi\u1ec7n th\u1eed nghi\u1ec7m l\u00e2m s\u00e0ng v\u1ec1 hi\u1ec7u qu\u1ea3 c\u1ee7a Lecanemab tr\u00ean 856 b\u1ec7nh nh\u00e2n m\u1eafc b\u1ec7nh Alzheimer giai \u0111o\u1ea1n \u0111\u1ea7u so v\u1edbi gi\u1ea3 d\u01b0\u1ee3c. Sau th\u1eddi gian \u0111i\u1ec1u tr\u1ecb t\u1eeb 9-59 th\u00e1ng, nghi\u00ean c\u1ee9u cho k\u1ebft lu\u1eadn r\u1eb1ng \u0111i\u1ec1u tr\u1ecb b\u1eb1ng Lecanemab gi\u00fap gi\u1ea3m \u0111\u00e1ng k\u1ec3 c\u00e1c m\u1ea3ng amyloid v\u00e0 l\u00e0m ch\u1eadm qu\u00e1 tr\u00ecnh suy gi\u1ea3m l\u00e2m s\u00e0ng<\/span><\/p>\n

    Tr\u00ean t\u1ea1p ch\u00ed Lancet, m\u1ed9t nghi\u00ean c\u1ee9u \u0111\u01b0\u1ee3c c\u00f4ng b\u1ed1 \u0111\u01b0\u1ee3c th\u1ef1c hi\u1ec7n t\u1ea1i Hoa K\u1ef3 cho k\u1ebft qu\u1ea3 t\u01b0\u01a1ng quan gi\u1eefa hi\u1ec7u qu\u1ea3 Lecanemab v\u00e0 vi\u1ec7c gi\u1ea3m t\u00ecnh tr\u1ea1ng suy gi\u1ea3m nh\u1eadn th\u1ee9c \u1edf 1795 b\u1ec7nh nh\u00e2n b\u1ecb suy gi\u1ea3m nh\u1eadn th\u1ee9c nh\u1eb9 ho\u1eb7c m\u1eafc b\u1ec7nh Alzheimer giai \u0111o\u1ea1n \u0111\u1ea7u, c\u1ed9ng v\u1edbi b\u1eb1ng ch\u1ee9ng v\u1ec1 amyloid khi ch\u1ee5p PET ho\u1eb7c x\u00e9t nghi\u1ec7m CSF, \u0111\u01b0\u1ee3c ch\u1ec9 \u0111\u1ecbnh ng\u1eabu nhi\u00ean \u0111\u1ec3 nh\u1eadn 10 mg lecanemab qua \u0111\u01b0\u1eddng truy\u1ec1n t\u0129nh m\u1ea1ch 2 tu\u1ea7n m\u1ed9t l\u1ea7n ho\u1eb7c gi\u1ea3 d\u01b0\u1ee3c ph\u00f9 h\u1ee3p trong 18 th\u00e1ng \u0111i\u1ec1u tr\u1ecb\u00a0<\/span><\/p>\n

    Ngu\u1ed3n: T\u1ed5ng h\u1ee3p<\/p>\n","protected":false},"excerpt":{"rendered":"

    Alzheimer l\u00e0 m\u1ed9t trong nh\u1eefng c\u0103n b\u1ec7nh l\u00fd n\u00e3o ph\u1ed5 bi\u1ebfn v\u00e0 ng\u00e0y c\u00e0ng gia t\u0103ng \u1edf nh\u1eefng ng\u01b0\u1eddi trung ni\u00ean v\u00e0 cao tu\u1ed5i. Hi\u1ec7n nay, vi\u1ec7c \u0111i\u1ec1u tr\u1ecb d\u1ee9t \u0111i\u1ec3m b\u1ec7nh Alzheimer v\u1eabn ch\u01b0a \u0111\u01b0\u1ee3c t\u00ecm th\u1ea5y. Tuy nhi\u00ean, Lecanumab – m\u1ed9t lo\u1ea1i thu\u1ed1c \u0111\u01b0\u1ee3c ph\u00e1t tri\u1ec3n b\u1edfi c\u00f4ng ty th\u1ebf gi\u1edbi Novartis v\u00e0 […]<\/p>\n","protected":false},"author":54,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[12,33],"tags":[3],"yoast_head":"\nLecanemab: gi\u1ea3i ph\u00e1p ti\u1ec1m n\u0103ng cho giai \u0111o\u1ea1n \u0111\u1ea7u b\u1ec7nh Alzheimer<\/title>\n<meta name=\"description\" content=\"Lecanemab l\u00e0 ph\u01b0\u01a1ng ph\u00e1p \u0111i\u1ec1u tr\u1ecb m\u1edbi th\u1ec3 l\u00e0m ch\u1eadm suy gi\u1ea3m nh\u1eadn th\u1ee9c nh\u1eb9 v\u00e0 gi\u1ea3m m\u1ea3ng amyloid-\u03b2 \u1edf b\u1ec7nh nh\u00e2n m\u1eafc b\u1ec7nh Alzheimer giai \u0111o\u1ea1n \u0111\u1ea7u\" \/>\n<meta name=\"robots\" content=\"noindex, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta 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