{"id":22569,"date":"2023-04-17T07:58:23","date_gmt":"2023-04-17T00:58:23","guid":{"rendered":"http:\/\/noithathoaphat.in\/ctv\/?p=22569"},"modified":"2023-04-18T12:51:01","modified_gmt":"2023-04-18T05:51:01","slug":"pcsk9-trong-dieu-tri-roi-loan-lipid-mau-co-gi-moi","status":"publish","type":"post","link":"http:\/\/noithathoaphat.in\/ctv\/index.php\/2023\/04\/17\/pcsk9-trong-dieu-tri-roi-loan-lipid-mau-co-gi-moi\/","title":{"rendered":"PCSK9 trong \u0111i\u1ec1u tr\u1ecb r\u1ed1i lo\u1ea1n lipid m\u00e1u c\u00f3 g\u00ec m\u1edbi?"},"content":{"rendered":"<p><strong>PCSK9 l\u00e0 m\u1ed9t enzyme c\u00f3 kh\u1ea3 n\u0103ng gi\u00fap lo\u1ea1i b\u1ecf c\u00e1c th\u1ee5 th\u1ec3 LDL (lipoprotein cholesterol c\u00f3 \u0111\u1ed9 m\u1eadt \u0111\u1ed9 th\u1ea5p) kh\u1ecfi b\u1ec1 m\u1eb7t c\u00e1c t\u1ebf b\u00e0o gan, d\u1eabn \u0111\u1ebfn t\u0103ng m\u1ee9c \u0111\u1ed9 cholesterol trong m\u00e1u \u0111\u01b0\u1ee3c FDA ph\u00ea duy\u1ec7t t\u1eeb n\u0103m 2017.PCSK9 l\u00e0 vi\u1ebft t\u1eaft c\u1ee7a proprotein convertase subtilisin\/kexin type 9, \u0111\u00e2y l\u00e0 m\u1ed9t protein \u0111\u01b0\u1ee3c s\u1ea3n xu\u1ea5t b\u1edfi c\u01a1 th\u1ec3 v\u00e0 c\u00f3 ch\u1ee9c n\u0103ng gi\u00fap \u0111i\u1ec1u ch\u1ec9nh l\u01b0\u1ee3ng cholesterol trong m\u00e1u b\u1eb1ng c\u00e1ch l\u00e0m gi\u1ea3m s\u1ed1 l\u01b0\u1ee3ng receptor LDL (low-density lipoprotein) tr\u00ean b\u1ec1 m\u1eb7t t\u1ebf b\u00e0o gan. <\/strong><\/p>\n<h2><strong>1.C\u01a1 ch\u1ebf t\u00e1c d\u1ee5ng<\/strong><\/h2>\n<ul>\n<li>Protein convertase subtilisin\/kexin type 9 (PCSK9) l\u00e0 enzyme lo\u1ea1i serine protease, \u0111\u01b0\u1ee3c m\u00e3 ho\u00e1 b\u1edfi gen PCSK9 v\u00e0 s\u1ea3n xu\u1ea5t t\u1ea1i gan. PCSK9 g\u1eafn v\u00e0o receptor c\u1ee7a lipoprotein tr\u1ecdng l\u01b0\u1ee3ng ph\u00e2n t\u1eed th\u1ea5p (LDL-R) tr\u00ean b\u1ec1 m\u1eb7t t\u1ebf b\u00e0o gan, d\u1eabn \u0111\u1ebfn tho\u00e1i gi\u1ea3m s\u1ed1 l\u01b0\u1ee3ng receptor n\u00e0y v\u00e0 do \u0111\u00f3 l\u00e0m t\u0103ng n\u1ed3ng \u0111\u1ed9 LDL-C trong m\u00e1u.<\/li>\n<li>Kh\u00e1ng th\u1ec3 kh\u00e1ng PCSK9 t\u01b0\u01a1ng t\u00e1c v\u1edbi v\u1ecb tr\u00ed g\u1eafn c\u1ee7a n\u00f3 tr\u00ean LDL-R, l\u00e0m t\u0103ng b\u1ed9c l\u1ed9 LDL-R v\u00e0 t\u1eeb \u0111\u00f3 l\u00e0m gi\u1ea3m n\u1ed3ng \u0111\u1ed9 LDL-C <strong>Alirocumab <\/strong><strong>v\u00e0 <\/strong><strong>evolocumab<\/strong> l\u00e0 c\u00e1c kh\u00e1ng th\u1ec3 \u0111\u01a1n d\u00f2ng ng\u01b0\u1eddi c\u00f3 kh\u1ea3 n\u0103ng g\u1eafn v\u00e0o PCSK9 t\u1ef1 do trong huy\u1ebft t\u01b0\u01a1ng, l\u00e0m t\u0103ng tho\u00e1i ho\u00e1 enzyme n\u00e0y, qua \u0111\u00f3 l\u00e0m gi\u1ea3m n\u1ed3ng \u0111\u1ed9 PCSK9. \u0110i\u1ec1u n\u00e0y gi\u00fap t\u0103ng s\u1ed1 l\u01b0\u1ee3ng LDL-R \u0111\u01b0\u1ee3c t\u00e1i s\u1eed d\u1ee5ng tr\u00ean b\u1ec1 m\u1eb7t t\u1ebf b\u00e0o gan, l\u00e0m gi\u1ea3m n\u1ed3ng \u0111\u1ed9 LDL-C trong m\u00e1u. C\u00e1c kh\u00e1ng th\u1ec3 n\u00e0y \u0111\u1eb7c hi\u1ec7u v\u1edbi PCSK9 v\u00e0 kh\u00f4ng g\u1eafn v\u00e0o c\u00e1c enzyme kh\u00e1c trong h\u1ecd PCSK.<strong>Inclisiran<\/strong> l\u00e0 ch\u1ea5t b\u1ea5t ho\u1ea1t, l\u00e0m gi\u1ea3m bi\u1ec3u hi\u1ec7n c\u1ee7a mRNA, qua \u0111\u00f3 l\u00e0m gi\u1ea3m n\u1ed3ng \u0111\u1ed9 PCSK9 th\u00f4ng qua vi\u1ec7c \u1ee9c ch\u1ebf t\u1ed5ng h\u1ee3p PCSK9.<\/li>\n<li>C\u00e1c th\u1eed nghi\u1ec7m g\u1ea7n \u0111\u00e2y cho th\u1ea5y, nh\u00f3m thu\u1ed1c n\u00e0y l\u00e0m gi\u1ea3m LDL-C r\u1ea5t hi\u1ec7u qu\u1ea3 v\u00e0 khi ph\u1ed1i h\u1ee3p v\u1edbi statin s\u1ebd l\u00e0m gi\u1ea3m m\u1ea1nh h\u01a1n n\u1eefa LDL-C v\u00e0 gi\u1ea3m c\u00e1c bi\u1ebfn c\u1ed1 l\u00e2m s\u00e0ng. Nguy\u00ean nh\u00e2n l\u00e0 d\u00f9ng statin c\u00f3 th\u1ec3 g\u00e2y h\u1ed3i \u1ee9ng t\u0103ng n\u1ed3ng \u0111\u1ed9 PCSK9, qua \u0111\u00f3 l\u00e0m gi\u1ea3m t\u00e1c d\u1ee5ng h\u1ea1 LDL-C c\u1ee7a statin.<\/li>\n<\/ul>\n<h2><strong>2.Ch\u1ec9 \u0111\u1ecbnh<\/strong><\/h2>\n<p>V\u00e0o n\u0103m 2015, C\u1ee5c qu\u1ea3n l\u00fd D\u01b0\u1ee3c ph\u1ea9m v\u00e0 th\u1ef1c ph\u1ea9m Hoa K\u1ef3 FDA \u0111\u00e3 ch\u1ea5p nh\u1eadn s\u1eed d\u1ee5ng c\u00e1c thu\u1ed1c \u1ee9c ch\u1ebf PCSK9 \u0111\u1ea7u ti\u00ean: Praluent (alirocumab) v\u00e0 Repatha (evolocumab).<\/p>\n<p>C\u00e1c ch\u1ec9 \u0111\u1ecbnh c\u1ee7a nh\u00f3m thu\u1ed1c n\u00e0y bao g\u1ed3m:<\/p>\n<ul>\n<li>T\u0103ng cholesterol m\u00e1u c\u00f3 t\u00ednh gia \u0111\u00ecnh lo\u1ea1i \u0111\u1ed3ng h\u1ee3p t\u1eed.<\/li>\n<li>R\u1ed1i lo\u1ea1n lipid m\u00e1u ti\u00ean ph\u00e1t kh\u00f3 \u0111\u00e1p \u1ee9ng v\u1edbi c\u00e1c thu\u1ed1c \u0111i\u1ec1u tr\u1ecb r\u1ed1i lo\u1ea1n lipid m\u00e1u kh\u00e1c.<\/li>\n<li>Ki\u1ec3m so\u00e1t n\u1ed3ng \u0111\u1ed9 LDL-C m\u1ee5c ti\u00eau khi kh\u00f3 kh\u1ed1ng ch\u1ebf b\u1edfi statin \u0111\u01a1n thu\u1ea7n. D\u1ef1 ph\u00f2ng c\u00e1c bi\u1ebfn c\u1ed1 tim m\u1ea1ch th\u1ee9 ph\u00e1t.<\/li>\n<\/ul>\n<h2><strong>3.Li\u1ec1u d\u00f9ng<\/strong><\/h2>\n<ul>\n<li>Alirocumab (Praluent):<\/li>\n<\/ul>\n<p>D\u1ea1ng \u0111\u00f3ng g\u00f3i: 75, 150 mg\/ml, s\u1eed d\u1ee5ng \u0111\u01a1n \u0111\u1ed9c, b\u00fat ti\u00eam \u0111\u00f3ng s\u1eb5n.<\/p>\n<p>Li\u1ec1u kh\u1edfi \u0111\u1ea7u: M\u1ed9t li\u1ec1u 75 mg m\u1ed7i 2 tu\u1ea7n Li\u1ec1u duy tr\u00ec: M\u1ed9t li\u1ec1u 75 \u2013 150 mg m\u1ed7i 2 tu\u1ea7n.<\/p>\n<p>C\u1ea7n ki\u1ec3m tra l\u1ea1i LDL-C trong v\u00f2ng 4-8 tu\u1ea7n sau khi b\u1eaft \u0111\u1ea7u \u0111i\u1ec1u tr\u1ecb \u0111\u1ec3 ch\u1ec9nh li\u1ec1u. C\u00f3 th\u1ec3 kh\u1edfi \u0111\u1ea7u ngay b\u1eb1ng li\u1ec1u 150 mg m\u1ed7i tu\u1ea7n n\u1ebfu b\u1ec7nh nh\u00e2n c\u00f3 t\u0103ng cholesterol m\u00e1u t\u00ednh ch\u1ea5t gia \u0111\u00ecnh th\u1ec3 \u0111\u1ed3ng h\u1ee3p, d\u1ecb h\u1ee3p ho\u1eb7c c\u00f3 nguy c\u01a1 r\u1ea5t cao v\u1edbi n\u1ed3ng \u0111\u1ed9 LDL-C &gt;50% so v\u1edbi m\u1ee5c ti\u00eau c\u1ea7n \u0111\u1ea1t.<\/p>\n<ul>\n<li>Evolocumab (Repatha):<\/li>\n<\/ul>\n<p>D\u1ea1ng \u0111\u00f3ng g\u00f3i: 140 mg\/mL, s\u1eed d\u1ee5ng \u0111\u01a1n \u0111\u1ed9c, b\u00fat ti\u00eam \u0111\u00f3ng s\u1eb5n. Li\u1ec1u trong \u0111i\u1ec1u tr\u1ecb r\u1ed1i lo\u1ea1n lipid m\u00e1u ti\u00ean ph\u00e1t ho\u1eb7c h\u1ed7n h\u1ee3p:<\/p>\n<p>M\u1ed9t li\u1ec1u 140 mg m\u1ed7i 2 tu\u1ea7n ho\u1eb7c M\u1ed9t li\u1ec1u 420 mg m\u1ed7i th\u00e1ng<\/p>\n<p>T\u0103ng cholesterol m\u00e1u c\u00f3 t\u00ednh gia \u0111\u00ecnh th\u1ec3 \u0111\u1ed3ng h\u1ee3p t\u1eed: M\u1ed9t li\u1ec1u 420 mg m\u1ed7i th\u00e1ng<\/p>\n<p>C\u00f3 th\u1ec3 t\u1edbi t\u0103ng t\u1edbi m\u1ed9t li\u1ec1u 420 mg m\u1ed7i 2 tu\u1ea7n sau 12 tu\u1ea7n (n\u1ebfu b\u1ec7nh nh\u00e2n \u0111ang l\u1ecdc huy\u1ebft t\u01b0\u01a1ng chu k\u1ef3)<\/p>\n<h2><strong>4.T\u00e1c d\u1ee5ng kh\u00f4ng mong mu\u1ed1n<\/strong><\/h2>\n<p>M\u1eb7c d\u00f9 t\u00e1c d\u1ee5ng kh\u00e1 m\u1ea1nh trong \u0111i\u1ec1u tr\u1ecb r\u1ed1i lo\u1ea1n lipid m\u00e1u nh\u01b0ng c\u00e1c thu\u1ed1c PCSK9 \u0111\u1ec1u c\u00f3 nh\u01b0\u1ee3c \u0111i\u1ec3m. C\u1ea3 hai thu\u1ed1c tr\u00ean c\u1ea7n ph\u1ea3i \u0111\u01b0\u1ee3c ti\u00eam sau m\u1ed7i 2-4 tu\u1ea7n n\u00ean g\u00e2y b\u1ea5t ti\u1ec7n cho kh\u00e1 nhi\u1ec1u ng\u01b0\u1eddi v\u00e0 c\u0169ng l\u00e0 nh\u1eefng thu\u1ed1c \u0111\u1eaft ti\u1ec1n.<\/p>\n<p>PCSK9 l\u00e0 m\u1ed9t lo\u1ea1i thu\u1ed1c \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng \u0111\u1ec3 \u0111i\u1ec1u tr\u1ecb t\u0103ng cholesterol m\u00e1u. Tuy nhi\u00ean, nh\u01b0 m\u1ecdi lo\u1ea1i thu\u1ed1c, PCSK9 c\u0169ng c\u00f3 th\u1ec3 g\u00e2y ra m\u1ed9t s\u1ed1 t\u00e1c d\u1ee5ng ph\u1ee5.<\/p>\n<p>M\u1ed9t nghi\u00ean c\u1ee9u \u0111\u01b0\u1ee3c c\u00f4ng b\u1ed1 tr\u00ean t\u1ea1p ch\u00ed The Lancet v\u00e0o n\u0103m 2017 \u0111\u00e3 \u0111\u00e1nh gi\u00e1 t\u00e1c d\u1ee5ng ph\u1ee5 c\u1ee7a PCSK9 tr\u00ean 27.438 b\u1ec7nh nh\u00e2n. K\u1ebft qu\u1ea3 cho th\u1ea5y, t\u00e1c d\u1ee5ng ph\u1ee5 c\u1ee7a thu\u1ed1c PCSK9 ch\u1ee7 y\u1ebfu l\u00e0 \u0111au \u0111\u1ea7u, \u0111au c\u01a1, \u0111au \u0111\u1edbn v\u00e0 s\u01b0ng t\u1ea1i ch\u1ed7 ti\u00eam. Tuy nhi\u00ean, t\u1ea5t c\u1ea3 c\u00e1c t\u00e1c d\u1ee5ng ph\u1ee5 n\u00e0y \u0111\u1ec1u l\u00e0 nh\u1eb9 v\u00e0 kh\u00f4ng g\u00e2y \u1ea3nh h\u01b0\u1edfng nghi\u00eam tr\u1ecdng \u0111\u1ebfn s\u1ee9c kh\u1ecfe c\u1ee7a b\u1ec7nh nh\u00e2n.<\/p>\n<p>Ngo\u00e0i nh\u1eefng t\u00e1c d\u1ee5ng ph\u1ee5 n\u00e0y, m\u1ed9t s\u1ed1 nghi\u00ean c\u1ee9u kh\u00e1c c\u0169ng \u0111\u00e3 \u0111\u1ec1 c\u1eadp \u0111\u1ebfn m\u1ed9t s\u1ed1 t\u00e1c d\u1ee5ng ph\u1ee5 kh\u00e1c c\u1ee7a PCSK9. Theo m\u1ed9t nghi\u00ean c\u1ee9u \u0111\u01b0\u1ee3c c\u00f4ng b\u1ed1 tr\u00ean t\u1ea1p ch\u00ed Circulation v\u00e0o n\u0103m 2018, s\u1eed d\u1ee5ng PCSK9 c\u00f3 th\u1ec3 g\u00e2y ra t\u0103ng nguy c\u01a1 b\u1ec7nh tim m\u1ea1ch v\u00e0 \u0111\u1ed9t qu\u1ef5. Tuy nhi\u00ean, t\u00e1c d\u1ee5ng n\u00e0y v\u1eabn c\u1ea7n \u0111\u01b0\u1ee3c x\u00e1c nh\u1eadn b\u1eb1ng nh\u1eefng nghi\u00ean c\u1ee9u l\u1edbn h\u01a1n v\u00e0 chi ti\u1ebft h\u01a1n.<\/p>\n<p>Ngo\u00e0i ra, vi\u1ec7c s\u1eed d\u1ee5ng PCSK9 c\u0169ng c\u00f3 th\u1ec3 g\u00e2y ra c\u00e1c v\u1ea5n \u0111\u1ec1 v\u1ec1 gi\u00e1 tr\u1ecb x\u00e9t nghi\u1ec7m cholesterol, nh\u01b0 l\u00e0m t\u0103ng h\u00e0m l\u01b0\u1ee3ng cholesterol LDL trong m\u00e1u. Vi\u1ec7c n\u00e0y c\u00f3 th\u1ec3 d\u1eabn \u0111\u1ebfn s\u1ef1 c\u1ea7n thi\u1ebft ph\u1ea3i \u0111i\u1ec1u ch\u1ec9nh li\u1ec1u l\u01b0\u1ee3ng thu\u1ed1c ho\u1eb7c t\u0103ng c\u01b0\u1eddng theo d\u00f5i s\u1ee9c kh\u1ecfe b\u1ec7nh nh\u00e2n.<\/p>\n<p>Nh\u01b0 v\u1eady,m\u1ed9t s\u1ed1 t\u00e1c d\u1ee5ng kh\u00f4ng mong mu\u1ed1n c\u1ee7a c\u00e1c ch\u1ea5t \u1ee9c ch\u1ebf PCSK9 bao g\u1ed3m:<\/p>\n<ul>\n<li>C\u00e1c t\u00e1c d\u1ee5ng ph\u1ee5 tr\u00ean da: ph\u00e1t ban, s\u01b0ng, \u0111au, m\u00e0y \u0111ay, ch\u00e0m, ng\u1ee9a, vi\u00eam m\u1ea1ch qu\u00e1 m\u1eabn, b\u1ea7m t\u00edm \u1edf v\u1ecb tr\u00ed ti\u00eam.<\/li>\n<li>C\u00e1c tri\u1ec7u ch\u1ee9ng th\u1ea7n kinh: l\u00fa l\u1eabn, kh\u00f3 t\u1eadp trung, ng\u1ee7 g\u00e0. C\u00e1c tri\u1ec7u ch\u1ee9ng c\u1ea3m l\u1ea1nh, c\u00fam.<\/li>\n<li>\u0110au l\u01b0ng.<\/li>\n<\/ul>\n<p>M\u1ed9t s\u1ed1 lo ng\u1ea1i kh\u00e1c:<\/p>\n<ul>\n<li>\u1ea2nh h\u01b0\u1edfng \u0111\u1ebfn ho\u1ea1t \u0111\u1ed9ng c\u1ee7a HCV. T\u0103ng t\u1ef7 l\u1ec7 m\u1eafc u \u0111\u1ea1i tr\u00e0ng.<\/li>\n<li>T\u0103ng \u0111\u1ec1 kh\u00e1ng insulin v\u00e0 \u0111\u00e1i th\u00e1o \u0111\u01b0\u1eddng<\/li>\n<\/ul>\n<h2>5.T\u00f3m t\u1eaft<\/h2>\n<p>Thu\u1ed1c d\u1ea1ng kh\u00e1ng th\u1ec3 \u0111\u01a1n d\u00f2ng \u1ee9c ch\u1ebf enzyme PCSK9 l\u00e0 m\u1ed9t lo\u1ea1i thu\u1ed1c gi\u1ea3m cholesterol trong m\u00e1u b\u1eb1ng c\u00e1ch ng\u0103n ch\u1eb7n s\u1ef1 k\u1ebft n\u1ed1i gi\u1eefa PCSK9 v\u00e0 th\u1ee5 th\u1ec3 LDL. Thu\u1ed1c n\u00e0y \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng nh\u01b0 m\u1ed9t bi\u1ec7n ph\u00e1p \u0111i\u1ec1u tr\u1ecb b\u1ed5 sung cho c\u00e1c b\u1ec7nh nh\u00e2n c\u00f3 m\u1ee9c \u0111\u1ed9 cholesterol cao, \u0111\u1eb7c bi\u1ec7t l\u00e0 cho nh\u1eefng ng\u01b0\u1eddi kh\u00f4ng \u0111\u1ea1t \u0111\u01b0\u1ee3c m\u1ee5c ti\u00eau gi\u1ea3m cholesterol b\u1eb1ng c\u00e1c bi\u1ec7n ph\u00e1p kh\u00e1c nh\u01b0 ch\u1ebf \u0111\u1ed9 \u0103n u\u1ed1ng v\u00e0 t\u1eadp th\u1ec3 d\u1ee5c. C\u00e1c lo\u1ea1i thu\u1ed1c kh\u00e1ng th\u1ec3 PCSK9 hi\u1ec7n c\u00f3 tr\u00ean th\u1ecb tr\u01b0\u1eddng bao g\u1ed3m<strong> evolocumab v\u00e0 alirocumab<\/strong>. Tuy nhi\u00ean, nh\u01b0 v\u1edbi b\u1ea5t k\u1ef3 lo\u1ea1i thu\u1ed1c n\u00e0o kh\u00e1c, c\u00e1c thu\u1ed1c kh\u00e1ng th\u1ec3 PCSK9 c\u0169ng c\u00f3 th\u1ec3 g\u00e2y ra m\u1ed9t s\u1ed1 t\u00e1c d\u1ee5ng ph\u1ee5.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>PCSK9 l\u00e0 m\u1ed9t enzyme c\u00f3 kh\u1ea3 n\u0103ng gi\u00fap lo\u1ea1i b\u1ecf c\u00e1c th\u1ee5 th\u1ec3 LDL (lipoprotein cholesterol c\u00f3 \u0111\u1ed9 m\u1eadt \u0111\u1ed9 th\u1ea5p) kh\u1ecfi b\u1ec1 m\u1eb7t c\u00e1c t\u1ebf b\u00e0o gan, d\u1eabn \u0111\u1ebfn t\u0103ng m\u1ee9c \u0111\u1ed9 cholesterol trong m\u00e1u \u0111\u01b0\u1ee3c FDA ph\u00ea duy\u1ec7t t\u1eeb n\u0103m 2017.PCSK9 l\u00e0 vi\u1ebft t\u1eaft c\u1ee7a proprotein convertase subtilisin\/kexin type 9, \u0111\u00e2y l\u00e0 m\u1ed9t [&hellip;]<\/p>\n","protected":false},"author":7,"featured_media":22573,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[12,33],"tags":[3],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v20.4 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>PCSK9 trong \u0111i\u1ec1u tr\u1ecb r\u1ed1i lo\u1ea1n lipid m\u00e1u c\u00f3 g\u00ec m\u1edbi? - Vinmec<\/title>\n<meta name=\"description\" content=\"PCSK9 trong \u0111i\u1ec1u tr\u1ecb r\u1ed1i lo\u1ea1n lipid m\u00e1u c\u00f3 g\u00ec m\u1edbi l\u00e0 c\u00e2u h\u1ecfi th\u01b0\u1eddng \u0111\u1eb7t ra. C\u01a1 ch\u1ebf, c\u00e1c ch\u1ec9 \u0111\u1ecbnh l\u00e2m s\u00e0ng ra sao s\u1ebd c\u00f3 trong b\u00e0i vi\u1ebft.\" \/>\n<meta name=\"robots\" content=\"noindex, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"PCSK9 trong \u0111i\u1ec1u tr\u1ecb r\u1ed1i lo\u1ea1n lipid m\u00e1u c\u00f3 g\u00ec m\u1edbi? - Vinmec\" \/>\n<meta property=\"og:description\" content=\"PCSK9 trong \u0111i\u1ec1u tr\u1ecb r\u1ed1i lo\u1ea1n lipid m\u00e1u c\u00f3 g\u00ec m\u1edbi l\u00e0 c\u00e2u h\u1ecfi th\u01b0\u1eddng \u0111\u1eb7t ra. C\u01a1 ch\u1ebf, c\u00e1c ch\u1ec9 \u0111\u1ecbnh l\u00e2m s\u00e0ng ra sao s\u1ebd c\u00f3 trong b\u00e0i vi\u1ebft.\" \/>\n<meta property=\"og:url\" content=\"http:\/\/noithathoaphat.in\/ctv\/index.php\/2023\/04\/17\/pcsk9-trong-dieu-tri-roi-loan-lipid-mau-co-gi-moi\/\" \/>\n<meta property=\"og:site_name\" content=\"Vinmec\" \/>\n<meta property=\"article:published_time\" content=\"2023-04-17T00:58:23+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2023-04-18T05:51:01+00:00\" \/>\n<meta property=\"og:image\" content=\"http:\/\/noithathoaphat.in\/ctv\/wp-content\/uploads\/2023\/04\/Mechanism-action-of-anti-PCSK9-monoclonal-antibody-mAb-and-statins-Anti-PCSK9-mAb.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"850\" \/>\n\t<meta property=\"og:image:height\" content=\"600\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"author\" content=\"L\u01b0\u01a1ng Vi\u1ebft T\u00e0i\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"L\u01b0\u01a1ng Vi\u1ebft T\u00e0i\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"5 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"http:\/\/noithathoaphat.in\/ctv\/index.php\/2023\/04\/17\/pcsk9-trong-dieu-tri-roi-loan-lipid-mau-co-gi-moi\/\",\"url\":\"http:\/\/noithathoaphat.in\/ctv\/index.php\/2023\/04\/17\/pcsk9-trong-dieu-tri-roi-loan-lipid-mau-co-gi-moi\/\",\"name\":\"PCSK9 trong \u0111i\u1ec1u tr\u1ecb r\u1ed1i lo\u1ea1n lipid m\u00e1u c\u00f3 g\u00ec m\u1edbi? - Vinmec\",\"isPartOf\":{\"@id\":\"http:\/\/noithathoaphat.in\/ctv\/#website\"},\"datePublished\":\"2023-04-17T00:58:23+00:00\",\"dateModified\":\"2023-04-18T05:51:01+00:00\",\"author\":{\"@id\":\"http:\/\/noithathoaphat.in\/ctv\/#\/schema\/person\/dded5c0d4cb1bb77d05cf29ab5f85629\"},\"description\":\"PCSK9 trong \u0111i\u1ec1u tr\u1ecb r\u1ed1i lo\u1ea1n lipid m\u00e1u c\u00f3 g\u00ec m\u1edbi l\u00e0 c\u00e2u h\u1ecfi th\u01b0\u1eddng \u0111\u1eb7t ra. C\u01a1 ch\u1ebf, c\u00e1c ch\u1ec9 \u0111\u1ecbnh l\u00e2m s\u00e0ng ra sao s\u1ebd c\u00f3 trong b\u00e0i vi\u1ebft.\",\"breadcrumb\":{\"@id\":\"http:\/\/noithathoaphat.in\/ctv\/index.php\/2023\/04\/17\/pcsk9-trong-dieu-tri-roi-loan-lipid-mau-co-gi-moi\/#breadcrumb\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"http:\/\/noithathoaphat.in\/ctv\/index.php\/2023\/04\/17\/pcsk9-trong-dieu-tri-roi-loan-lipid-mau-co-gi-moi\/\"]}]},{\"@type\":\"BreadcrumbList\",\"@id\":\"http:\/\/noithathoaphat.in\/ctv\/index.php\/2023\/04\/17\/pcsk9-trong-dieu-tri-roi-loan-lipid-mau-co-gi-moi\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"http:\/\/noithathoaphat.in\/ctv\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"PCSK9 trong \u0111i\u1ec1u tr\u1ecb r\u1ed1i lo\u1ea1n lipid m\u00e1u c\u00f3 g\u00ec m\u1edbi?\"}]},{\"@type\":\"WebSite\",\"@id\":\"http:\/\/noithathoaphat.in\/ctv\/#website\",\"url\":\"http:\/\/noithathoaphat.in\/ctv\/\",\"name\":\"Vinmec\",\"description\":\"H\u1ec7 th\u1ed1ng Y t\u1ebf Vinmec\",\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"http:\/\/noithathoaphat.in\/ctv\/?s={search_term_string}\"},\"query-input\":\"required name=search_term_string\"}],\"inLanguage\":\"en-US\"},{\"@type\":\"Person\",\"@id\":\"http:\/\/noithathoaphat.in\/ctv\/#\/schema\/person\/dded5c0d4cb1bb77d05cf29ab5f85629\",\"name\":\"L\u01b0\u01a1ng Vi\u1ebft T\u00e0i\",\"image\":{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"http:\/\/noithathoaphat.in\/ctv\/#\/schema\/person\/image\/\",\"url\":\"http:\/\/2.gravatar.com\/avatar\/50f51f67852bc7e49c0b8b60a1fefe3e?s=96&d=mm&r=g\",\"contentUrl\":\"http:\/\/2.gravatar.com\/avatar\/50f51f67852bc7e49c0b8b60a1fefe3e?s=96&d=mm&r=g\",\"caption\":\"L\u01b0\u01a1ng Vi\u1ebft T\u00e0i\"},\"url\":\"http:\/\/noithathoaphat.in\/ctv\/index.php\/author\/viettai304-304gmail-com\/\"}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"PCSK9 trong \u0111i\u1ec1u tr\u1ecb r\u1ed1i lo\u1ea1n lipid m\u00e1u c\u00f3 g\u00ec m\u1edbi? - Vinmec","description":"PCSK9 trong \u0111i\u1ec1u tr\u1ecb r\u1ed1i lo\u1ea1n lipid m\u00e1u c\u00f3 g\u00ec m\u1edbi l\u00e0 c\u00e2u h\u1ecfi th\u01b0\u1eddng \u0111\u1eb7t ra. C\u01a1 ch\u1ebf, c\u00e1c ch\u1ec9 \u0111\u1ecbnh l\u00e2m s\u00e0ng ra sao s\u1ebd c\u00f3 trong b\u00e0i vi\u1ebft.","robots":{"index":"noindex","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"og_locale":"en_US","og_type":"article","og_title":"PCSK9 trong \u0111i\u1ec1u tr\u1ecb r\u1ed1i lo\u1ea1n lipid m\u00e1u c\u00f3 g\u00ec m\u1edbi? - Vinmec","og_description":"PCSK9 trong \u0111i\u1ec1u tr\u1ecb r\u1ed1i lo\u1ea1n lipid m\u00e1u c\u00f3 g\u00ec m\u1edbi l\u00e0 c\u00e2u h\u1ecfi th\u01b0\u1eddng \u0111\u1eb7t ra. C\u01a1 ch\u1ebf, c\u00e1c ch\u1ec9 \u0111\u1ecbnh l\u00e2m s\u00e0ng ra sao s\u1ebd c\u00f3 trong b\u00e0i vi\u1ebft.","og_url":"http:\/\/noithathoaphat.in\/ctv\/index.php\/2023\/04\/17\/pcsk9-trong-dieu-tri-roi-loan-lipid-mau-co-gi-moi\/","og_site_name":"Vinmec","article_published_time":"2023-04-17T00:58:23+00:00","article_modified_time":"2023-04-18T05:51:01+00:00","og_image":[{"width":850,"height":600,"url":"http:\/\/noithathoaphat.in\/ctv\/wp-content\/uploads\/2023\/04\/Mechanism-action-of-anti-PCSK9-monoclonal-antibody-mAb-and-statins-Anti-PCSK9-mAb.jpg","type":"image\/jpeg"}],"author":"L\u01b0\u01a1ng Vi\u1ebft T\u00e0i","twitter_card":"summary_large_image","twitter_misc":{"Written by":"L\u01b0\u01a1ng Vi\u1ebft T\u00e0i","Est. reading time":"5 minutes"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"WebPage","@id":"http:\/\/noithathoaphat.in\/ctv\/index.php\/2023\/04\/17\/pcsk9-trong-dieu-tri-roi-loan-lipid-mau-co-gi-moi\/","url":"http:\/\/noithathoaphat.in\/ctv\/index.php\/2023\/04\/17\/pcsk9-trong-dieu-tri-roi-loan-lipid-mau-co-gi-moi\/","name":"PCSK9 trong \u0111i\u1ec1u tr\u1ecb r\u1ed1i lo\u1ea1n lipid m\u00e1u c\u00f3 g\u00ec m\u1edbi? - Vinmec","isPartOf":{"@id":"http:\/\/noithathoaphat.in\/ctv\/#website"},"datePublished":"2023-04-17T00:58:23+00:00","dateModified":"2023-04-18T05:51:01+00:00","author":{"@id":"http:\/\/noithathoaphat.in\/ctv\/#\/schema\/person\/dded5c0d4cb1bb77d05cf29ab5f85629"},"description":"PCSK9 trong \u0111i\u1ec1u tr\u1ecb r\u1ed1i lo\u1ea1n lipid m\u00e1u c\u00f3 g\u00ec m\u1edbi l\u00e0 c\u00e2u h\u1ecfi th\u01b0\u1eddng \u0111\u1eb7t ra. C\u01a1 ch\u1ebf, c\u00e1c ch\u1ec9 \u0111\u1ecbnh l\u00e2m s\u00e0ng ra sao s\u1ebd c\u00f3 trong b\u00e0i vi\u1ebft.","breadcrumb":{"@id":"http:\/\/noithathoaphat.in\/ctv\/index.php\/2023\/04\/17\/pcsk9-trong-dieu-tri-roi-loan-lipid-mau-co-gi-moi\/#breadcrumb"},"inLanguage":"en-US","potentialAction":[{"@type":"ReadAction","target":["http:\/\/noithathoaphat.in\/ctv\/index.php\/2023\/04\/17\/pcsk9-trong-dieu-tri-roi-loan-lipid-mau-co-gi-moi\/"]}]},{"@type":"BreadcrumbList","@id":"http:\/\/noithathoaphat.in\/ctv\/index.php\/2023\/04\/17\/pcsk9-trong-dieu-tri-roi-loan-lipid-mau-co-gi-moi\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"http:\/\/noithathoaphat.in\/ctv\/"},{"@type":"ListItem","position":2,"name":"PCSK9 trong \u0111i\u1ec1u tr\u1ecb r\u1ed1i lo\u1ea1n lipid m\u00e1u c\u00f3 g\u00ec m\u1edbi?"}]},{"@type":"WebSite","@id":"http:\/\/noithathoaphat.in\/ctv\/#website","url":"http:\/\/noithathoaphat.in\/ctv\/","name":"Vinmec","description":"H\u1ec7 th\u1ed1ng Y t\u1ebf Vinmec","potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"http:\/\/noithathoaphat.in\/ctv\/?s={search_term_string}"},"query-input":"required name=search_term_string"}],"inLanguage":"en-US"},{"@type":"Person","@id":"http:\/\/noithathoaphat.in\/ctv\/#\/schema\/person\/dded5c0d4cb1bb77d05cf29ab5f85629","name":"L\u01b0\u01a1ng Vi\u1ebft T\u00e0i","image":{"@type":"ImageObject","inLanguage":"en-US","@id":"http:\/\/noithathoaphat.in\/ctv\/#\/schema\/person\/image\/","url":"http:\/\/2.gravatar.com\/avatar\/50f51f67852bc7e49c0b8b60a1fefe3e?s=96&d=mm&r=g","contentUrl":"http:\/\/2.gravatar.com\/avatar\/50f51f67852bc7e49c0b8b60a1fefe3e?s=96&d=mm&r=g","caption":"L\u01b0\u01a1ng Vi\u1ebft T\u00e0i"},"url":"http:\/\/noithathoaphat.in\/ctv\/index.php\/author\/viettai304-304gmail-com\/"}]}},"_links":{"self":[{"href":"http:\/\/noithathoaphat.in\/ctv\/index.php\/wp-json\/wp\/v2\/posts\/22569"}],"collection":[{"href":"http:\/\/noithathoaphat.in\/ctv\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"http:\/\/noithathoaphat.in\/ctv\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"http:\/\/noithathoaphat.in\/ctv\/index.php\/wp-json\/wp\/v2\/users\/7"}],"replies":[{"embeddable":true,"href":"http:\/\/noithathoaphat.in\/ctv\/index.php\/wp-json\/wp\/v2\/comments?post=22569"}],"version-history":[{"count":5,"href":"http:\/\/noithathoaphat.in\/ctv\/index.php\/wp-json\/wp\/v2\/posts\/22569\/revisions"}],"predecessor-version":[{"id":24047,"href":"http:\/\/noithathoaphat.in\/ctv\/index.php\/wp-json\/wp\/v2\/posts\/22569\/revisions\/24047"}],"wp:featuredmedia":[{"embeddable":true,"href":"http:\/\/noithathoaphat.in\/ctv\/index.php\/wp-json\/wp\/v2\/media\/22573"}],"wp:attachment":[{"href":"http:\/\/noithathoaphat.in\/ctv\/index.php\/wp-json\/wp\/v2\/media?parent=22569"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"http:\/\/noithathoaphat.in\/ctv\/index.php\/wp-json\/wp\/v2\/categories?post=22569"},{"taxonomy":"post_tag","embeddable":true,"href":"http:\/\/noithathoaphat.in\/ctv\/index.php\/wp-json\/wp\/v2\/tags?post=22569"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}