{"id":22519,"date":"2023-04-17T08:00:54","date_gmt":"2023-04-17T01:00:54","guid":{"rendered":"http:\/\/noithathoaphat.in\/ctv\/?p=22519"},"modified":"2023-04-17T10:54:31","modified_gmt":"2023-04-17T03:54:31","slug":"fibrate-va-cac-van-de-can-luu-y-trong-thuc-hanh","status":"publish","type":"post","link":"http:\/\/noithathoaphat.in\/ctv\/index.php\/2023\/04\/17\/fibrate-va-cac-van-de-can-luu-y-trong-thuc-hanh\/","title":{"rendered":"Fibrate v\u00e0 c\u00e1c v\u1ea5n \u0111\u1ec1 c\u1ea7n l\u01b0u \u00fd trong th\u1ef1c h\u00e0nh"},"content":{"rendered":"<p><strong>Fibrate \u0111\u01b0\u1ee3c coi l\u00e0 li\u1ec7u ph\u00e1p \u0111\u1ea7u ti\u00ean cho b\u1ec7nh nh\u00e2n t\u0103ng triglyceride m\u00e1u n\u1eb7ng. C\u00e1c thu\u1ed1c nh\u00f3m fibrate l\u00e0m gi\u1ea3m n\u1ed3ng \u0111\u1ed9 triglyceride 20- 50% l\u00e0m t\u0103ng HDL-C kho\u1ea3ng 10-20%, LDL-C c\u00f3 th\u1ec3 gi\u1ea3m 5 \u2013 20% nh\u01b0ng LDL-C c\u00f3 th\u1ec3 t\u0103ng n\u1ebfu n\u1ed3ng \u0111\u1ed9 ch\u1ea5t b\u00e9o trung t\u00ednh cao.<\/strong><\/p>\n<p><strong>1.C\u01a1 ch\u1ebf t\u00e1c d\u1ee5ng<\/strong><\/p>\n<ul>\n<li>C\u00f3 nhi\u1ec1u c\u01a1 ch\u1ebf gi\u00fap fibrate gi\u1ea3m n\u1ed3ng \u0111\u1ed9 triglyceride trong huy\u1ebft t\u01b0\u01a1ng:\u1ee8c ch\u1ebf t\u1ed5ng h\u1ee3p acid b\u00e9o.<\/li>\n<li>T\u0103ng s\u1ef1 d\u1ecb h\u00f3a acid b\u00e9o b\u1eb1ng c\u00e1ch k\u00edch th\u00edch s\u1ef1 h\u1ea5p thu c\u1ee7a ty th\u1ec3 v\u00e0 oxy h\u00f3a c\u00e1c acid b\u00e9o.<\/li>\n<li>Gi\u1ea3m s\u1ea3n xu\u1ea5t triglyceride b\u1eb1ng c\u00e1ch \u1ee9c ch\u1ebf diacylglycerol acyltransferase 2 (DGAT2), m\u1ed9t lo\u1ea1i enzyme x\u00fac t\u00e1c s\u1ef1 h\u00ecnh th\u00e0nh triglyceride t\u1eeb diglyceride. T\u0103ng kh\u1ea3 n\u0103ng th\u1ee7y ph\u00e2n ch\u1ea5t b\u00e9o trung t\u00ednh c\u1ee7a VLDL (v\u00e0 chylomicrons) b\u1eb1ng c\u00e1ch k\u00edch th\u00edch bi\u1ec3u hi\u1ec7n lipoprotein lipase (LPL). Ho\u1ea1t \u0111\u1ed9ng c\u1ee7a LPL c\u0169ng \u0111\u01b0\u1ee3c t\u0103ng c\u01b0\u1eddng b\u1edfi s\u1ef1 gi\u1ea3m bi\u1ec3u hi\u1ec7n c\u1ee7a apolipoprotein gan-C3, m\u1ed9t lipoprotein l\u00e0m suy gi\u1ea3m ho\u1ea1t \u0111\u1ed9ng LPL.<\/li>\n<\/ul>\n<p>Li\u1ec7u ph\u00e1p fibrate d\u01b0\u1eddng nh\u01b0 c\u00f3 t\u00e1c d\u1ee5ng hi\u1ec7p \u0111\u1ed3ng v\u1edbi niacin tr\u00ean HDL-C, v\u00ec c\u01a1 ch\u1ebf ho\u1ea1t \u0111\u1ed9ng c\u1ee7a ch\u00fang b\u1ed5 sung cho nhau. Fibrate k\u00edch th\u00edch s\u1ea3n xu\u1ea5t apo-A1 \u1edf gan trong khi niacin \u1ee9c ch\u1ebf qu\u00e1 tr\u00ecnh d\u1ecb h\u00f3a n\u00e0y.<\/p>\n<p><strong>2.D\u01b0\u1ee3c \u0111\u1ed9ng h\u1ecdc c\u1ee7a thu\u1ed1c<\/strong><\/p>\n<ul>\n<li>Gemfibrozil \u0111\u01b0\u1ee3c h\u1ea5p th\u1ee5 ho\u00e0n to\u00e0n sau khi u\u1ed1ng, \u0111\u1ea1t n\u1ed3ng \u0111\u1ed9 \u0111\u1ec9nh trong huy\u1ebft t\u01b0\u01a1ng 1-2h sau khi d\u00f9ng thu\u1ed1c. C\u1ea3 t\u1ed1c \u0111\u1ed9 v\u00e0 m\u1ee9c \u0111\u1ed9 h\u1ea5p thu c\u1ee7a thu\u1ed1c \u0111\u1ec1u t\u0103ng khi d\u00f9ng tr\u01b0\u1edbc b\u1eefa \u0103n n\u1eeda gi\u1edd, v\u00ec v\u1eady n\u00ean d\u00f9ng thu\u1ed1c tr\u01b0\u1edbc b\u1eefa \u0103n. Ph\u1ea7n l\u1edbn thu\u1ed1c \u0111\u01b0\u1ee3c \u0111\u00e0o th\u1ea3i qua th\u1eadn v\u1edbi th\u1eddi gian b\u00e1n th\u1ea3i l\u00e0 kho\u1ea3ng 1,1h.<\/li>\n<li>Fenofibrate l\u00e0 m\u1ed9t ti\u1ec1n ch\u1ea5t c\u1ee7a h\u1ee3p ch\u1ea5t ho\u1ea1t \u0111\u1ed9ng, acid fenofibric. Fenofibrate \u0111\u01b0\u1ee3c chuy\u1ec3n \u0111\u1ed5i b\u1eb1ng c\u00e1ch th\u1ee7y ph\u00e2n este th\u00e0nh acid fenofibric. Li\u00ean k\u1ebft protein l\u00e0 kho\u1ea3ng 99%. Acid fenofibric \u0111\u01b0\u1ee3c chuy\u1ec3n h\u00f3a b\u1eb1ng c\u00e1ch k\u1ebft h\u1ee3p v\u1edbi acid glucuronic v\u00e0 b\u00e0i ti\u1ebft ch\u1ee7 y\u1ebfu qua n\u01b0\u1edbc ti\u1ec3u (60%) d\u01b0\u1edbi d\u1ea1ng acid fenofibric v\u00e0 acid furofibric glucuronide. Kho\u1ea3ng 25% \u0111\u01b0\u1ee3c b\u00e0i ti\u1ebft qua ph\u00e2n. C\u1ea3 acid fenofibrate v\u00e0 fenofibric \u0111\u1ec1u kh\u00f4ng tr\u1ea3i qua qu\u00e1 tr\u00ecnh chuy\u1ec3n h\u00f3a oxy h\u00f3a b\u1edfi CYP P450 \u1edf m\u1ee9c \u0111\u1ed9 \u0111\u00e1ng k\u1ec3. Th\u1eddi gian b\u00e1n h\u1ee7y kho\u1ea3ng 20h.<\/li>\n<li>Bezafibrate c\u00f3 th\u1eddi gian b\u00e1n h\u1ee7y l\u00e0 1-2h v\u00e0 g\u1eafn v\u1edbi protein l\u00e0 94-96%. B\u00e0i ti\u1ebft g\u1ea7n nh\u01b0 ho\u00e0n to\u00e0n qua th\u1eadn, v\u1edbi 95% \u0111\u01b0\u1ee3c ph\u1ee5c h\u1ed3i qua n\u01b0\u1edbc ti\u1ec3u.<\/li>\n<\/ul>\n<p><strong>3.Ch\u1ed1ng ch\u1ec9 \u0111\u1ecbnh v\u00e0 th\u1eadn tr\u1ecdng<\/strong><\/p>\n<p>Ch\u1ed1ng ch\u1ec9 \u0111\u1ecbnh bao g\u1ed3m ph\u1ea3n \u1ee9ng qu\u00e1 m\u1eabn v\u1edbi thu\u1ed1c ho\u1eb7c ti\u1ec1n s\u1eed b\u1ec7nh gan \u0111ang ho\u1ea1t \u0111\u1ed9ng (bao g\u1ed3m c\u1ea3 nh\u1eefng ng\u01b0\u1eddi b\u1ecb x\u01a1 gan m\u1eadt nguy\u00ean ph\u00e1t) v\u00e0 b\u1ea5t th\u01b0\u1eddng ch\u1ee9c n\u0103ng gan dai d\u1eb3ng kh\u00f4ng gi\u1ea3i th\u00edch \u0111\u01b0\u1ee3c, r\u1ed1i lo\u1ea1n ch\u1ee9c n\u0103ng th\u1eadn n\u1eb7ng (bao g\u1ed3m c\u1ea3 b\u1ec7nh nh\u00e2n \u0111\u01b0\u1ee3c l\u1ecdc m\u00e1u) ho\u1eb7c b\u1ec7nh t\u00fai m\u1eadt.<\/p>\n<p>S\u1ef1 k\u1ebft h\u1ee3p c\u1ee7a gemfibrozil v\u1edbi thu\u1ed1c h\u1ea1 \u0111\u01b0\u1eddng huy\u1ebft l\u00e0 ch\u1ed1ng ch\u1ec9 \u0111\u1ecbnh v\u00ec nguy c\u01a1 h\u1ea1 \u0111\u01b0\u1eddng huy\u1ebft n\u1eb7ng.<\/p>\n<p>Fibrate l\u00e0 thu\u1ed1c lo\u1ea1i C khi mang thai v\u00e0 ch\u1ec9 n\u00ean s\u1eed d\u1ee5ng trong thai k\u1ef3 n\u1ebfu l\u1ee3i \u00edch v\u01b0\u1ee3t qua \u0111\u01b0\u1ee3c nguy c\u01a1 ti\u1ec1m \u1ea9n cho thai nhi. Fibrate ch\u1ed1ng ch\u1ec9 \u0111\u1ecbnh \u1edf c\u00e1c b\u00e0 m\u1eb9 cho con b\u00fa v\u00ec t\u00ednh ch\u1ea5t t\u1ea1o u \u0111\u01b0\u1ee3c th\u1ea5y trong c\u00e1c nghi\u00ean c\u1ee9u tr\u00ean \u0111\u1ed9ng v\u1eadt.<\/p>\n<h2><strong>4.Li\u1ec1u d\u00f9ng<\/strong><\/h2>\n<h3>4.1. Fenofibrate<\/h3>\n<ul>\n<li>Li\u1ec1u khuy\u1ebfn c\u00e1o c\u1ee7a fenofibrate s\u1ebd kh\u00e1c nhau t\u00f9y s\u1ea3n ph\u1ea9m \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng. Li\u1ec1u ban \u0111\u1ea7u \u0111\u01b0\u1ee3c \u0111\u1ec1 ngh\u1ecb c\u1ee7a acid fenofbric l\u00e0 135 mg m\u1ed7i ng\u00e0y m\u1ed9t l\u1ea7n.<\/li>\n<li>\u0110\u1ed1i v\u1edbi b\u1ec7nh nh\u00e2n suy ch\u1ee9c n\u0103ng th\u1eadn n\u00ean gi\u1ea3m li\u1ec1u ban \u0111\u1ea7u c\u1ee7a fenofibrate ho\u1eb7c acid fenofibric. N\u00ean d\u00f9ng li\u1ec1u th\u1ea5p khi m\u1ee9c l\u1ecdc c\u1ea7u th\u1eadn (GFR) d\u01b0\u1edbi 60 mL\/ph\u00fat v\u00e0 c\u00f3 th\u1ec3 \u0111\u01b0\u1ee3c d\u00f9ng m\u00e0 kh\u00f4ng li\u00ean quan \u0111\u1ebfn b\u1eefa \u0103n. Fenofibrate v\u00e0 acid fenofibric kh\u00f4ng n\u00ean s\u1eed d\u1ee5ng n\u1ebfu suy th\u1eadn v\u1eeba ho\u1eb7c n\u1eb7ng (v\u00ed d\u1ee5, n\u1ebfu GFR &lt;30 mL\/ph\u00fat). Ch\u1ee9c n\u0103ng th\u1eadn n\u00ean \u0111\u01b0\u1ee3c \u0111\u00e1nh gi\u00e1 tr\u01b0\u1edbc khi b\u1eaft \u0111\u1ea7u s\u1eed d\u1ee5ng fibrate. N\u1ebfu trong qu\u00e1 tr\u00ecnh theo d\u00f5i, GFR gi\u1ea3m li\u00ean t\u1ee5c xu\u1ed1ng m\u1ee9c \u2264 30 mL\/ph\u00fat n\u00ean ng\u1eebng s\u1eed d\u1ee5ng fibrate.<\/li>\n<li>C\u1ea7n th\u1eadn tr\u1ecdng khi d\u00f9ng k\u1ebft h\u1ee3p colchicine v\u00ec c\u00e1c tr\u01b0\u1eddng h\u1ee3p b\u1ecb b\u1ec7nh c\u01a1, bao g\u1ed3m c\u1ea3 ti\u00eau c\u01a1 v\u00e2n \u0111\u00e3 \u0111\u01b0\u1ee3c b\u00e1o c\u00e1o.<\/li>\n<\/ul>\n<h3>4.2 Gemfibrozil<\/h3>\n<p>Li\u1ec1u khuy\u1ebfn c\u00e1o c\u1ee7a gemfibrozil l\u00e0 600 mg hai l\u1ea7n m\u1ed9t ng\u00e0y, d\u00f9ng 30 ph\u00fat tr\u01b0\u1edbc b\u1eefa \u0103n s\u00e1ng v\u00e0 t\u1ed1i. C\u1ea7n ch\u1ec9nh li\u1ec1u theo GFR v\u1edbi li\u1ec1u gi\u1ea3m xu\u1ed1ng 600 mg m\u1ed7i ng\u00e0y m\u1ed9t l\u1ea7n khi GFR d\u01b0\u1edbi 60 mL\/ph\u00fat. Kh\u00f4ng khuy\u1ebfn c\u00e1o s\u1eed d\u1ee5ng fibrate \u1edf nh\u1eefngb\u1ec7nh nh\u00e2n ch\u1ea1y th\u1eadn nh\u00e2n t\u1ea1o l\u00e2u d\u00e0i, c\u1eeda s\u1ed5 \u0111i\u1ec1u tr\u1ecb h\u1eb9p. \u0110\u00e3 c\u00f3 b\u00e1o c\u00e1o v\u1ec1 vi\u1ec7c l\u00e0m suy gi\u1ea3m ch\u1ee9c n\u0103ng th\u1eadn \u1edf b\u1ec7nh nh\u00e2n c\u00f3 creatinin n\u1ec1n l\u1edbn h\u01a1n 2,0 mg\/dL v\u00e0 c\u1ea7n xem x\u00e9t d\u00f9ng li\u1ec1u th\u1ea5p h\u01a1n so v\u1edbi \u0111i\u1ec1u tr\u1ecb thay th\u1ebf.<\/p>\n<p>Khi k\u1ebft h\u1ee3p gemfibrozil v\u1edbi thu\u1ed1c ch\u1ed1ng \u0111\u00f4ng m\u00e1u, c\u1ea7n th\u1eadn tr\u1ecdng v\u00e0 gi\u1ea3m li\u1ec1u thu\u1ed1c ch\u1ed1ng \u0111\u00f4ng m\u00e1u nh\u1eb1m ng\u0103n ng\u1eeba bi\u1ebfn ch\u1ee9ng ch\u1ea3y m\u00e1u.<\/p>\n<p><strong>5.T\u00e1c d\u1ee5ng kh\u00f4ng mong mu\u1ed1n<\/strong><\/p>\n<ul>\n<li>T\u1ed5n th\u01b0\u01a1ng c\u01a1 \u0111\u00e3 \u0111\u01b0\u1ee3c b\u00e1o c\u00e1o khi s\u1eed d\u1ee5ng fibrate v\u00e0 nguy c\u01a1 t\u0103ng l\u00ean khi fibrate \u0111\u01b0\u1ee3c d\u00f9ng c\u00f9ng v\u1edbi statin, \u0111\u1eb7c bi\u1ec7t \u1edf b\u1ec7nh nh\u00e2n cao tu\u1ed5i v\u00e0 \u1edf b\u1ec7nh nh\u00e2n \u0111\u00e1i th\u00e1o \u0111\u01b0\u1eddng, suy th\u1eadn ho\u1eb7c suy gi\u00e1p. T\u1ef7 l\u1ec7 b\u1ec7nh c\u01a1 x\u1ea3y ra v\u1edbi gemfibrozil v\u00e0 statin \u01b0\u1edbc t\u00ednh cao h\u01a1n 33 l\u1ea7n so v\u1edbi statin k\u1ebft h\u1ee3p v\u1edbi fenmfibrate. N\u00ean tr\u00e1nh k\u1ebft h\u1ee3p tr\u1eeb khi l\u1ee3i \u00edch c\u1ee7a vi\u1ec7c thay \u0111\u1ed5i n\u1ed3ng \u0111\u1ed9 lipid c\u00f3 th\u1ec3 cao h\u01a1n nguy c\u01a1 t\u0103ng th\u00eam khi ph\u1ed1i h\u1ee3p thu\u1ed1c n\u00e0y.<\/li>\n<li>S\u1eed d\u1ee5ng fenofibrate v\u1edbi li\u1ec1u 96 \u2013 145 mg\/24h c\u00f3 li\u00ean quan \u0111\u1ebfn s\u1ef1 gia t\u0103ng transaminase gan trong huy\u1ebft thanh.<\/li>\n<li>C\u00e1c x\u00e9t nghi\u1ec7m ch\u1ee9c n\u0103ng gan, bao g\u1ed3m ALT n\u00ean \u0111\u01b0\u1ee3c theo d\u00f5i \u0111\u1ecbnh k\u1ef3 trong khi \u0111i\u1ec1u tr\u1ecb v\u00e0 ng\u1eebng \u0111i\u1ec1u tr\u1ecb n\u1ebfu n\u1ed3ng \u0111\u1ed9 enzyme t\u0103ng k\u00e9o d\u00e0i h\u01a1n 3 l\u1ea7n so v\u1edbi ng\u01b0\u1ee1ng tr\u00ean.<\/li>\n<li>Fenofibrate c\u00f3 th\u1ec3 l\u00e0m t\u0103ng n\u1ed3ng \u0111\u1ed9 creatinin 10 \u2013 20%, v\u00ec v\u1eady c\u1ea7n theo d\u00f5i ch\u1ee9c n\u0103ng th\u1eadn \u0111\u1ecbnh k\u1ef3 \u1edf b\u1ec7nh nh\u00e2n suy th\u1eadn. Nguy\u00ean nh\u00e2n c\u1ee7a t\u00ecnh tr\u1ea1ng t\u0103ng c\u00f2n ch\u01b0a r\u00f5 r\u00e0ng m\u1eb7c d\u00f9 c\u00e1c fibrate c\u00f3 th\u1ec3 l\u00e0m t\u0103ng s\u1ea3n xu\u1ea5t creatinine m\u00e0 kh\u00f4ng l\u00e0m suy gi\u1ea3m GFR. Fenofibrate v\u00e0 bezafibrate c\u00f3 nguy c\u01a1 g\u00e2y t\u0103ng creatinine nhi\u1ec1u h\u01a1n so v\u1edbi gemfibrozil.<\/li>\n<li>Fibrate l\u00e0m thay \u0111\u1ed5i th\u00e0nh ph\u1ea7n \u0111\u01b0\u1eddng m\u1eadt, gi\u1ea3m h\u00e0m l\u01b0\u1ee3ng acid m\u1eadt v\u00e0 t\u0103ng h\u00e0m l\u01b0\u1ee3ng cholesterol. T\u0103ng ti\u1ebft m\u1eadt c\u00f3 th\u1ec3 l\u00e0 m\u1ed9t c\u01a1 ch\u1ebf ch\u00ednh \u0111\u1ec3 lo\u1ea1i b\u1ecf cholesterol ra kh\u1ecfi c\u01a1 th\u1ec3 nh\u01b0ng l\u00e0m t\u0103ng s\u1ea3n xu\u1ea5t m\u1eadt.<\/li>\n<li>Vi\u00eam t\u1ee5y \u0111\u00e3 \u0111\u01b0\u1ee3c b\u00e1o c\u00e1o \u1edf nh\u1eefng b\u1ec7nh nh\u00e2n d\u00f9ng fenofibrate ho\u1eb7c gemfibrozil.<\/li>\n<li>Thuy\u00ean t\u1eafc ph\u1ed5i x\u1ea3y ra \u1edf 1% nh\u00f3m d\u00f9ng fenofibrate, so v\u1edbi 0,7% \u1edf nh\u00f3m gi\u1ea3 d\u01b0\u1ee3c (p = 0,022) trong th\u1eed nghi\u1ec7m FIELD. \u0110\u1eb7c bi\u1ec7t, \u0111i\u1ec1u tr\u1ecb b\u1eb1ng fibrate v\u00e0 fenofibrate \u0111\u01b0\u1ee3c bi\u1ebft l\u00e0 l\u00e0m t\u0103ng m\u1ee9c homocysteine<\/li>\n<\/ul>\n","protected":false},"excerpt":{"rendered":"<p>Fibrate \u0111\u01b0\u1ee3c coi l\u00e0 li\u1ec7u ph\u00e1p \u0111\u1ea7u ti\u00ean cho b\u1ec7nh nh\u00e2n t\u0103ng triglyceride m\u00e1u n\u1eb7ng. C\u00e1c thu\u1ed1c nh\u00f3m fibrate l\u00e0m gi\u1ea3m n\u1ed3ng \u0111\u1ed9 triglyceride 20- 50% l\u00e0m t\u0103ng HDL-C kho\u1ea3ng 10-20%, LDL-C c\u00f3 th\u1ec3 gi\u1ea3m 5 \u2013 20% nh\u01b0ng LDL-C c\u00f3 th\u1ec3 t\u0103ng n\u1ebfu n\u1ed3ng \u0111\u1ed9 ch\u1ea5t b\u00e9o trung t\u00ednh cao. 1.C\u01a1 ch\u1ebf t\u00e1c d\u1ee5ng [&hellip;]<\/p>\n","protected":false},"author":7,"featured_media":22532,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[12,33],"tags":[3],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v20.4 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Fibrate v\u00e0 c\u00e1c v\u1ea5n \u0111\u1ec1 c\u1ea7n l\u01b0u \u00fd trong th\u1ef1c h\u00e0nh<\/title>\n<meta name=\"description\" content=\"Fibrate v\u00e0 c\u00e1c v\u1ea5n \u0111\u1ec1 c\u1ea7n l\u01b0u \u00fd trong th\u1ef1c h\u00e0nh l\u00e0 nh\u1eefng v\u1ea5n \u0111\u1ec1 quan t\u00e2m trong th\u1ef1c h\u00e0nh l\u00e2m s\u00e0ng. 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