{"id":22496,"date":"2023-04-18T11:30:29","date_gmt":"2023-04-18T04:30:29","guid":{"rendered":"http:\/\/noithathoaphat.in\/ctv\/?p=22496"},"modified":"2023-04-18T12:30:12","modified_gmt":"2023-04-18T05:30:12","slug":"nhom-thuoc-statin-va-nhung-dieu-can-biet-trong-thuc-hanh","status":"publish","type":"post","link":"http:\/\/noithathoaphat.in\/ctv\/index.php\/2023\/04\/18\/nhom-thuoc-statin-va-nhung-dieu-can-biet-trong-thuc-hanh\/","title":{"rendered":"Nh\u00f3m thu\u1ed1c Statin v\u00e0 nh\u1eefng \u0111i\u1ec1u c\u1ea7n bi\u1ebft trong th\u1ef1c h\u00e0nh"},"content":{"rendered":"<p><strong>Nh\u00f3m thu\u1ed1c StatinNh\u00f3m thu\u1ed1c Statin m\u1ea1nh v\u1eabn l\u00e0 \u01b0u ti\u00ean l\u1ef1a ch\u1ecdn h\u00e0ng \u0111\u1ea7u trong \u0111i\u1ec1u tr\u1ecb c\u00e1c r\u1ed1i lo\u1ea1n lipid m\u00e1u, \u0111\u1eb7c bi\u1ec7t tr\u00ean nh\u1eefng b\u1ec7nh nh\u00e2n t\u0103ng lipid m\u00e1u c\u00f3 t\u00ednh ch\u1ea5t gia \u0111\u00ecnh, b\u1ec7nh nh\u00e2n nguy c\u01a1 tim m\u1ea1ch r\u1ea5t cao, nguy c\u01a1 cao, trung b\u00ecnh.\u00a0<\/strong><\/p>\n<h2>1.Atorvastatin<\/h2>\n<p>Li\u1ec1u kh\u1edfi \u0111\u1ea7u c\u1ee7a statin n\u00e0y \u0111\u01b0\u1ee3c khuy\u1ebfn c\u00e1o l\u00e0 10 \u2013 20mg (t\u1ed1i \u0111a 80mg) ng\u00e0y m\u1ed9t l\u1ea7n. Atorvastatin c\u00f3 th\u1ec3 \u0111\u01b0\u1ee3c d\u00f9ng nh\u01b0 m\u1ed9t li\u1ec1u duy nh\u1ea5t v\u00e0o b\u1ea5t c\u1ee9 l\u00fac n\u00e0o trong ng\u00e0y, kh\u00f4ng ph\u00e2n bi\u1ec7t th\u1eddi gian b\u1eefa \u0103n. N\u1ed3ng \u0111\u1ed9 lipid n\u00ean \u0111\u01b0\u1ee3c x\u00e9t nghi\u1ec7m l\u1ea1i sau v\u00f2ng 2-4 tu\u1ea7n v\u00e0 n\u00ean \u0111i\u1ec1u ch\u1ec9nh li\u1ec1u theo m\u1ee5c ti\u00eau \u0111i\u1ec1u tr\u1ecb. Suy th\u1eadn kh\u00f4ng \u1ea3nh h\u01b0\u1edfng \u0111\u1ebfn n\u1ed3ng \u0111\u1ed9 statin n\u00e0y trong huy\u1ebft t\u01b0\u01a1ng, do \u0111\u00f3 kh\u00f4ng c\u1ea7n \u0111i\u1ec1u ch\u1ec9nh li\u1ec1u \u1edf b\u1ec7nh nh\u00e2n suy gi\u1ea3m ch\u1ee9c n\u0103ng th\u1eadn.<\/p>\n<p>M\u1ed9t s\u1ed1 l\u01b0u \u00fd:<\/p>\n<p>Atorvastatin n\u00ean tr\u00e1nh \u1edf nh\u1eefng b\u1ec7nh nh\u00e2n d\u00f9ng cyclosporine, thu\u1ed1c \u1ee9c ch\u1ebf protease c\u1ee7a virus g\u00e2y suy gi\u1ea3m mi\u1ec5n d\u1ecbch \u1edf ng\u01b0\u1eddi (HIV), tipranavir ph\u1ed1i h\u1ee3p v\u1edbi ritonavir ho\u1eb7c thu\u1ed1c \u1ee9c ch\u1ebf protease c\u1ee7a virus vi\u00eam gan C, telaprevir.<\/p>\n<p>C\u1ea7n th\u1eadn tr\u1ecdng (v\u00e0 s\u1eed d\u1ee5ng li\u1ec1u th\u1ea5p nh\u1ea5t c\u1ea7n thi\u1ebft) khi k\u00ea \u0111\u01a1n atorvastatin k\u1ebft h\u1ee3p v\u1edbi ph\u1ed1i h\u1ee3p thu\u1ed1c \u1ee9c ch\u1ebf protease HIV, lopinavir ph\u1ed1i h\u1ee3p v\u1edbi ritonavir. Li\u1ec1u atorvastatin n\u00ean \u0111\u01b0\u1ee3c gi\u1edbi h\u1ea1n \u1edf m\u1ee9c 20 mg\/24h khi s\u1eed d\u1ee5ng v\u1edbi clarithromycin, itraconazole ho\u1eb7c \u1edf nh\u1eefng b\u1ec7nh nh\u00e2n nhi\u1ec5m HIV s\u1eed d\u1ee5ng k\u1ebft h\u1ee3p saquinavir c\u1ed9ng v\u1edbi ritonavir, darunavir c\u1ed9ng v\u1edbi ritonavir, fosamprenavir ho\u1eb7c fosamprenavir v\u1edbi ritonavir.<\/p>\n<p>\u1ede nh\u1eefng b\u1ec7nh nh\u00e2n HIV d\u00f9ng nelnavir ho\u1eb7c thu\u1ed1c \u1ee9c ch\u1ebf protease c\u1ee7a vi\u00eam gan C, boceprevir, li\u1ec1u atorvastatin kh\u00f4ng \u0111\u01b0\u1ee3c v\u01b0\u1ee3t qu\u00e1 40mg\/24h.<\/p>\n<h2>2.Rosuvastatin<\/h2>\n<p>Li\u1ec1u kh\u1edfi \u0111\u1ea7u \u0111\u01b0\u1ee3c khuy\u1ebfn c\u00e1o c\u1ee7a rosuvastatin l\u00e0 10-20 mg (li\u1ec1u t\u1ed1i \u0111a 40 mg) m\u1ed7i ng\u00e0y m\u1ed9t l\u1ea7n v\u00e0o b\u1ea5t c\u1ee9 l\u00fac n\u00e0o trong ng\u00e0y.<\/p>\n<p>\u0110\u1ed1i v\u1edbi b\u1ec7nh nh\u00e2n b\u1ecb t\u0103ng LDL-C (&gt; 190 mg\/dL) \u1edf m\u1ee9c cao ho\u1eb7c c\u1ea7n ki\u1ec3m so\u00e1t ch\u1eb7t ch\u1ebd n\u1ed3ng \u0111\u1ed9 LDL-C c\u00f3 th\u1ec3 c\u00e2n nh\u1eafc d\u00f9ng li\u1ec1u kh\u1edfi \u0111\u1ea7u 20 mg. Sau khi b\u1eaft \u0111\u1ea7u ho\u1eb7c sau khi ch\u1ec9nh li\u1ec1u rosuvastatin, c\u1ea7n x\u00e9t nghi\u1ec7m n\u1ed3ng \u0111\u1ed9 lipid sau 2 \u2013 4 tu\u1ea7n v\u00e0 ch\u1ec9nh li\u1ec1u theo m\u1ee5c ti\u00eau \u0111i\u1ec1u tr\u1ecb. Li\u1ec1u 40 mg ch\u1ec9 n\u00ean s\u1eed d\u1ee5ng cho nh\u1eefng b\u1ec7nh nh\u00e2n ch\u01b0a \u0111\u1ea1t \u0111\u01b0\u1ee3c m\u1ee5c ti\u00eau LDL-C khi s\u1eed d\u1ee5ng li\u1ec1u 20 mg. B\u1eaft \u0111\u1ea7u \u0111i\u1ec1u tr\u1ecb b\u1eb1ng rosuvastatin v\u1edbi li\u1ec1u 5 \u2013 10 mg m\u1ed7i ng\u00e0y t\u00f9y theo m\u1ee9c LDL-C ban \u0111\u1ea7u v\u00e0 LDL-C m\u1ee5c ti\u00eau.<\/p>\n<p>M\u1ed9t s\u1ed1 l\u01b0u \u00fd:<\/p>\n<p>Rosuvastatin l\u00e0 nh\u00f3m thu\u1ed1c statin \u0111\u01b0\u1ee3c chuy\u1ec3n h\u00f3a qua men CYP450-2C9, kh\u00f4ng chuy\u1ec3n h\u00f3a qua men CYP450-3A4 n\u00ean \u00edt g\u1eb7p t\u01b0\u01a1ng t\u00e1c thu\u1ed1c h\u01a1n. Tuy nhi\u00ean n\u00ean tr\u00e1nh s\u1eed d\u1ee5ng rosuvastatin v\u1edbi gemfibrozil v\u00e0 li\u1ec1u gi\u1edbi h\u1ea1n \u1edf m\u1ee9c 10 mg\/24h n\u1ebfu ph\u1ea3i s\u1eed d\u1ee5ng. Li\u1ec1u rosuvastatin kh\u00f4ng \u0111\u01b0\u1ee3c v\u01b0\u1ee3t qu\u00e1 5 mg\/24h khi s\u1eed d\u1ee5ng v\u1edbi cyclosporine. C\u1ea7n th\u1eadn tr\u1ecdng khi d\u00f9ng ph\u1ed1i h\u1ee3p rosuvastatin v\u1edbi thu\u1ed1c \u1ee9c ch\u1ebf protease k\u1ebft h\u1ee3p v\u1edbi ritonavir. Li\u1ec1u rosuvastatin n\u00ean gi\u1edbi h\u1ea1n \u1edf m\u1ee9c 10 mg\/24h khi \u0111\u01b0\u1ee3c \u0111i\u1ec1u tr\u1ecb k\u1ebft h\u1ee3p v\u1edbi ritonavir c\u1ed9ng v\u1edbi lopinavir ho\u1eb7c ritonavir c\u1ed9ng v\u1edbi atazanavir. Th\u1eadn tr\u1ecdng khi d\u00f9ng c\u00f9ng niacin, fenobrate, colchicine ho\u1eb7c coumarin.<\/p>\n<p>\u1ede nh\u1eefng b\u1ec7nh nh\u00e2n b\u1ecb suy th\u1eadn n\u1eb7ng (GFR &lt;30 mL\/ph\u00fat\/1,73m2) v\u00e0 ch\u01b0a ph\u1ea3i ch\u1ea1y th\u1eadn nh\u00e2n t\u1ea1o n\u00ean b\u1eaft \u0111\u1ea7u li\u1ec1u 5 mg\/24h v\u00e0 kh\u00f4ng v\u01b0\u1ee3t qu\u00e1 10 mg\/24h. \u1ede b\u1ec7nh nh\u00e2n ch\u1ea1y th\u1eadn nh\u00e2n t\u1ea1o, n\u1ed3ng \u0111\u1ed9 thu\u1ed1c trong huy\u1ebft t\u01b0\u01a1ng cao h\u01a1n kho\u1ea3ng 50% ng\u01b0\u1eddi b\u00ecnh th\u01b0\u1eddng. N\u00ean gi\u1ea3m li\u1ec1u rosuvastatin \u1edf b\u1ec7nh nh\u00e2n c\u00f3 protein ni\u1ec7u ho\u1eb7c ti\u1ec3u m\u00e1u ch\u01b0a r\u00f5 nguy\u00ean nh\u00e2n.<\/p>\n<h2>3.Simvastatin<\/h2>\n<p>Li\u1ec1u kh\u1edfi \u0111\u1ea7u th\u00f4ng th\u01b0\u1eddng \u0111\u01b0\u1ee3c khuy\u1ebfn c\u00e1o l\u00e0 10 \u2013 20 mg\/24h (li\u1ec1u t\u1ed1i \u0111a 40 mg). Tuy nhi\u00ean, \u0111\u1ed1i v\u1edbi b\u1ec7nh nh\u00e2n c\u00f3 nguy c\u01a1 tim m\u1ea1ch cao, li\u1ec1u kh\u1edfi \u0111\u1ea7u l\u00e0 40mg\/24h. Do t\u0103ng nguy c\u01a1 ti\u00eau c\u01a1 v\u00e2n, \u0111\u1eb7c bi\u1ec7t trong n\u0103m \u0111\u1ea7u \u0111i\u1ec1u tr\u1ecb n\u00ean n\u1ebfu kh\u00f4ng \u0111\u1ea1t m\u1ee5c ti\u00eau LDL-C khi s\u1eed d\u1ee5ng li\u1ec1u 40 mg c\u1ea7n k\u1ebft h\u1ee3p th\u00eam nh\u00f3m thu\u1ed1c kh\u00e1c ho\u1eb7c chuy\u1ec3n sang nh\u00f3m thu\u1ed1c statin c\u01b0\u1eddng \u0111\u1ed9 cao thay v\u00ec t\u0103ng li\u1ec1u l\u00ean 80 mg.<\/p>\n<p>S\u1eed d\u1ee5ng k\u1ebft h\u1ee3p simvastatin v\u1edbi c\u00e1c ch\u1ea5t \u1ee9c ch\u1ebf CYP3A4 m\u1ea1nh, gembrozil, cyclosporin ho\u1eb7c danazol l\u00e0 ch\u1ed1ng ch\u1ec9 \u0111\u1ecbnh.Khi d\u00f9ng thu\u1ed1c c\u00f9ng verapamil, diltiazem ho\u1eb7c dronedarone th\u00ec li\u1ec1u h\u1eb1ng ng\u00e0y kh\u00f4ng \u0111\u01b0\u1ee3c v\u01b0\u1ee3t qu\u00e1 10 mg\/24h v\u00e0 kh\u00f4ng v\u01b0\u1ee3t qu\u00e1 20 mg\/24h khi d\u00f9ng c\u00f9ng v\u1edbi amiodarone, amlodipine ho\u1eb7c ranolazine.<\/p>\n<h2>4.Pitavastatin<\/h2>\n<p>Li\u1ec1u kh\u1edfi \u0111\u1ea7u \u0111\u01b0\u1ee3c khuy\u1ebfn c\u00e1o l\u00e0 2 mg\/24h (li\u1ec1u t\u1ed1i \u0111a 4 mg\/24h). C\u1ea7n x\u00e9t nghi\u1ec7m n\u1ed3ng \u0111\u1ed9 lipid sau 2 \u2013 4 tu\u1ea7n \u0111\u1ec3 ch\u1ec9nh li\u1ec1u. B\u1ec7nh nh\u00e2n suy th\u1eadn v\u1eeba v\u00e0 n\u1eb7ng (GFR 30 \u2013 59 mL\/ph\u00fat\/1,73m2 v\u00e0 15 \u2013 29 mL\/ph\u00fat\/1,73 m2, t\u01b0\u01a1ng \u1ee9ng) c\u0169ng nh\u01b0 b\u1ec7nh th\u1eadn giai \u0111o\u1ea1n cu\u1ed1i ch\u1ea1y th\u1eadn nh\u00e2n t\u1ea1o, li\u1ec1u kh\u1edfi \u0111\u1ea7u l\u00e0 1 mg\/24h v\u00e0 li\u1ec1u t\u1ed1i \u0111a 2 mg\/24h.<\/p>\n<p>Ch\u1ed1ng ch\u1ec9 \u0111\u1ecbnh d\u00f9ng pitavastatin \u0111\u1ed3ng th\u1eddi v\u1edbi cyclosporin. Li\u1ec1u kh\u00f4ng v\u01b0\u1ee3t qu\u00e1 1 mg\/24h \u1edf b\u1ec7nh nh\u00e2n d\u00f9ng erythromycin v\u00e0 2 mg\/24h \u1edf b\u1ec7nh nh\u00e2n d\u00f9ng rifampicin. N\u00ean tr\u00e1nh d\u00f9ng pitavastatin v\u1edbi gefibrozil v\u00e0 th\u1eadn tr\u1ecdng khi d\u00f9ng c\u00f9ng v\u1edbi nh\u00f3m fibrate. Vi\u1ec7c gi\u1ea3m li\u1ec1u n\u00ean \u0111\u01b0\u1ee3c xem x\u00e9t \u1edf nh\u1eefng b\u1ec7nh nh\u00e2n d\u00f9ng niacin. N\u00ean th\u1eadn tr\u1ecdng khi d\u00f9ng c\u00f9ng colchicine do nguy c\u01a1 t\u0103ng nguy c\u01a1 b\u1ec7nh v\u1ec1 c\u01a1.<\/p>\n<h2>5.Fluvastatin<\/h2>\n<p>Ph\u1ea1m vi li\u1ec1u khuy\u1ebfn c\u00e1o l\u00e0 20-80 mg\/24h. Kh\u1edfi \u0111\u1ea7u li\u1ec1u 20 mg khi c\u1ea7n gi\u1ea3m LDL-C d\u01b0\u1edbi 25%. Khi c\u1ea7n gi\u1ea3m LDL-C h\u01a1n 50%, li\u1ec1u kh\u1edfi \u0111\u1ea7u l\u00e0 40 mg, u\u1ed1ng v\u00e0o bu\u1ed5i t\u1ed1i. C\u00f3 th\u1ec3 d\u00f9ng \u0111\u1ebfn li\u1ec1u 80mg (d\u1ea1ng ph\u00f3ng th\u00edch k\u00e9o d\u00e0i (XR) d\u00f9ng m\u1ed9t l\u1ea7n duy nh\u1ea5t ho\u1eb7c 80 mg chia 2 l\u1ea7n\/24h). C\u00e1c vi\u00ean d\u1ea1ng XR kh\u00f4ng n\u00ean b\u1ecb nghi\u1ec1n n\u00e1t ho\u1eb7c b\u1ecb nhai khi u\u1ed1ng.<\/p>\n<p>Li\u1ec1u Fuvastatin n\u00ean gi\u1edbi h\u1ea1n \u1edf 20 mg x 2 l\u1ea7n\/24h n\u1ebfu \u0111ang d\u00f9ng cyclosporin ho\u1eb7c uconazole. S\u1eed d\u1ee5ng th\u1eadn tr\u1ecdng Fuvastatin khi b\u1ec7nh nh\u00e2n \u0111ang d\u00f9ng fibrate, niacin, glibenclamide, phenytoin ho\u1eb7c coumarin.<\/p>\n<p>Fluvastatin l\u00e0 statin ch\u01b0a \u0111\u01b0\u1ee3c nghi\u00ean c\u1ee9u \u1edf li\u1ec1u l\u1edbn h\u01a1n 40 mg \u1edf b\u1ec7nh nh\u00e2n suy th\u1eadn n\u1eb7ng, do \u0111\u00f3 n\u00ean th\u1eadn tr\u1ecdng khi \u0111i\u1ec1u tr\u1ecb cho nh\u1eefng \u0111\u1ed1i t\u01b0\u1ee3ng n\u00e0y \u1edf li\u1ec1u cao h\u01a1n. Fluvastatin c\u00f3 th\u1ec3 d\u00f9ng m\u00e0 kh\u00f4ng li\u00ean quan \u0111\u1ebfn b\u1eefa \u0103n. Gi\u1ea3m t\u1ed1i \u0111a m\u1ee9c LDL-C c\u00f3 th\u1ec3 \u0111\u1ea1t \u0111\u01b0\u1ee3c trong v\u00f2ng 4 tu\u1ea7n.<\/p>\n<h2>6.Pravastatin<\/h2>\n<p>Li\u1ec1u kh\u1edfi \u0111\u1ea7u khuy\u1ebfn c\u00e1o cho pravastatin l\u00e0 40 mg x 1 l\u1ea7n\/24h. N\u1ebfu li\u1ec1u n\u00e0y kh\u00f4ng \u0111\u1ea1t \u0111\u01b0\u1ee3c m\u1ee9c cholesterol mong mu\u1ed1n, li\u1ec1u 80 mg\/24h c\u00f3 th\u1ec3 \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng. \u1ede b\u1ec7nh nh\u00e2n b\u1ecb suy th\u1eadn \u0111\u00e1ng k\u1ec3 n\u00ean b\u1eaft \u0111\u1ea7u t\u1eeb li\u1ec1u 10mg\/24h.<\/p>\n<p>Pravastatin\u00a0 l\u00e0 nh\u00f3m thu\u1ed1c statin c\u00f3 th\u1ec3 \u0111\u01b0\u1ee3c d\u00f9ng li\u1ec1u duy nh\u1ea5t v\u00e0o b\u1ea5t k\u1ef3 th\u1eddi \u0111i\u1ec3m n\u00e0o trong ng\u00e0y. V\u00ec t\u00e1c d\u1ee5ng t\u1ed1i \u0111a \u0111\u1ea1t \u0111\u01b0\u1ee3c trong v\u00f2ng 4 tu\u1ea7n n\u00ean c\u1ea7n x\u00e9t nghi\u1ec7m lipid m\u00e1u \u0111\u1ec3 ch\u1ec9nh li\u1ec1u trong kho\u1ea3ng th\u1eddi gian n\u00e0y.<\/p>\n<p>B\u1eaft \u0111\u1ea7u pravastatin \u1edf li\u1ec1u 10 mg v\u00e0 kh\u00f4ng v\u01b0\u1ee3t qu\u00e1 20 mg\/24h khi d\u00f9ng c\u00f9ng v\u1edbi cyclosporine. Li\u1ec1u kh\u00f4ng v\u01b0\u1ee3t qu\u00e1 40 mg\/24h khi d\u00f9ng c\u00f9ng v\u1edbi clarithromycin. N\u00ean tr\u00e1nh pravastatin \u1edf nh\u1eefng b\u1ec7nh nh\u00e2n d\u00f9ng gembrozil v\u00e0 th\u1eadn tr\u1ecdng khi d\u00f9ng c\u00f9ng fibrate kh\u00e1c ho\u1eb7c colchicine. N\u00ean gi\u1ea3m li\u1ec1u \u1edf b\u1ec7nh nh\u00e2n d\u00f9ng niacin.<\/p>\n<h2>7.Lovastatin<\/h2>\n<p>Li\u1ec1u kh\u1edfi \u0111\u1ea7u th\u00f4ng th\u01b0\u1eddng \u0111\u01b0\u1ee3c khuy\u1ebfn c\u00e1o l\u00e0 20 mg x 1 l\u1ea7n\/24h v\u1edbi b\u1eefa \u0103n t\u1ed1i. Ph\u1ea1m vi li\u1ec1u l\u00e0 10 \u2013 80 mg\/24h trong m\u1ed9t l\u1ea7n ho\u1eb7c chia hai l\u1ea7n. C\u00f3 th\u1ec3 c\u00e2n nh\u1eafc kh\u1edfi \u0111\u1ea7u li\u1ec1u 10 mg khi c\u1ea7n gi\u1ea3m LDL-C d\u01b0\u1edbi 20%. C\u1ea7n \u0111i\u1ec1u ch\u1ec9nh li\u1ec1u trong kho\u1ea3ng th\u1eddi gian 4 tu\u1ea7n tr\u1edf l\u00ean. \u1ede b\u1ec7nh nh\u00e2n suy th\u1eadn n\u1eb7ng, c\u00e2n nh\u1eafc khi cho li\u1ec1u tr\u00ean 20mg\/24h.<\/p>\n<p>Vi\u1ec7c s\u1eed d\u1ee5ng lovastatin v\u1edbi c\u00e1c ch\u1ea5t \u1ee9c ch\u1ebf m\u1ea1nh CYP3A4 l\u00e0 ch\u1ed1ng ch\u1ec9 \u0111\u1ecbnh. N\u00ean tr\u00e1nh d\u00f9ng c\u00f9ng gembrozil ho\u1eb7c cyclosporine. Li\u1ec1u lovastatin kh\u00f4ng v\u01b0\u1ee3t qu\u00e1 20 mg\/24h khi d\u00f9ng c\u00f9ng v\u1edbi danazol, diltiazem, dronedarone ho\u1eb7c verapamil v\u00e0 kh\u00f4ng v\u01b0\u1ee3t qu\u00e1 40 mg\/24h khi d\u00f9ng c\u00f9ng v\u1edbi amiodarone. C\u1ea7n th\u1eadn tr\u1ecdng khi d\u00f9ng chung v\u1edbi colchicine ho\u1eb7c ranolazine v\u00ec nguy c\u01a1 b\u1ec7nh c\u01a1, bao g\u1ed3m c\u1ea3 ti\u00eau c\u01a1 v\u00e2n.<\/p>\n<p><a href=\"https:\/\/www.vinmec.com\/\"><strong>B\u1ec7nh vi\u1ec7n \u0110a khoa Qu\u1ed1c t\u1ebf Vinmec<\/strong><\/a> c\u00f3 \u0111\u1ed9i ng\u0169 D\u01b0\u1ee3c s\u0129 d\u01b0\u1ee3c l\u00e2m s\u00e0ng v\u00e0 \u0111\u00e3 \u0111\u01b0a h\u1ec7 th\u1ed1ng m\u00e1y m\u00f3c, thi\u1ebft b\u1ecb hi\u1ec7n \u0111\u1ea1i \u0111\u1ea1t chu\u1ea9n v\u00e0o c\u00f4ng t\u00e1c th\u0103m kh\u00e1m, ch\u1ea9n \u0111o\u00e1n v\u00e0 \u0111i\u1ec1u tr\u1ecb h\u1ed7 tr\u1ee3 c\u00e1c b\u1ec7nh l\u00fd v\u1ec1 tim m\u1ea1ch.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Nh\u00f3m thu\u1ed1c StatinNh\u00f3m thu\u1ed1c Statin m\u1ea1nh v\u1eabn l\u00e0 \u01b0u ti\u00ean l\u1ef1a ch\u1ecdn h\u00e0ng \u0111\u1ea7u trong \u0111i\u1ec1u tr\u1ecb c\u00e1c r\u1ed1i lo\u1ea1n lipid m\u00e1u, \u0111\u1eb7c bi\u1ec7t tr\u00ean nh\u1eefng b\u1ec7nh nh\u00e2n t\u0103ng lipid m\u00e1u c\u00f3 t\u00ednh ch\u1ea5t gia \u0111\u00ecnh, b\u1ec7nh nh\u00e2n nguy c\u01a1 tim m\u1ea1ch r\u1ea5t cao, nguy c\u01a1 cao, trung b\u00ecnh.\u00a0 1.Atorvastatin Li\u1ec1u kh\u1edfi \u0111\u1ea7u c\u1ee7a statin [&hellip;]<\/p>\n","protected":false},"author":7,"featured_media":23424,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[12,33],"tags":[3],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v20.4 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Nh\u00f3m thu\u1ed1c Statin v\u00e0 nh\u1eefng \u0111i\u1ec1u c\u1ea7n bi\u1ebft trong th\u1ef1c h\u00e0nh<\/title>\n<meta name=\"description\" content=\"Statin v\u00e0 nh\u1eefng \u0111i\u1ec1u c\u1ea7n bi\u1ebft trong th\u1ef1c h\u00e0nh v\u1ea5n \u0111\u1ec1 \u0111\u01b0\u1ee3c quan t\u00e2m trong c\u00e1c b\u1ec7nh tim m\u1ea1ch. 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