{"id":21407,"date":"2023-04-16T08:48:13","date_gmt":"2023-04-16T01:48:13","guid":{"rendered":"http:\/\/noithathoaphat.in\/ctv\/?p=21407"},"modified":"2023-04-17T13:01:34","modified_gmt":"2023-04-17T06:01:34","slug":"sars-cov-2","status":"publish","type":"post","link":"http:\/\/noithathoaphat.in\/ctv\/index.php\/2023\/04\/16\/sars-cov-2\/","title":{"rendered":"C\u00e1c nh\u00f3m thu\u1ed1c \u0111i\u1ec1u tr\u1ecb virus SARS-CoV-2"},"content":{"rendered":"

C\u00e1c nh\u00e0 khoa h\u1ecdc v\u00e0 c\u00e1c t\u1ed5 ch\u1ee9c y t\u1ebf tr\u00ean to\u00e0n th\u1ebf gi\u1edbi \u0111ang ti\u1ebfp t\u1ee5c nghi\u00ean c\u1ee9u v\u1ec1 virus SARS-CoV-2 v\u00e0 COVID-19 \u0111\u1ec3 t\u00ecm ra c\u00e1c thu\u1ed1c\u00a0 \u0111i\u1ec1u tr\u1ecb v\u00e0 ph\u01b0\u01a1ng ph\u00e1p d\u1ef1 ph\u00f2ng . Trong \u0111\u00f3 ,l\u00e0 s\u1ef1 ra \u0111\u1eddi c\u1ee7a c\u00e1c nh\u00f3m thu\u1ed1c \u0111i\u1ec1u tr\u1ecb COVID 19 . Vi\u1ec7c n\u1eafm v\u1eefng c\u00e1c ch\u1ec9 \u0111\u1ecbnh, ch\u1ed1ng ch\u1ec9 \u0111\u1ecbnh v\u00e0 li\u1ec1u d\u00f9ng s\u1ebd h\u1ed7 tr\u1ee3 B\u00e1c s\u0129 r\u1ea5t nhi\u1ec1u trong vi\u1ec7c l\u1ef1a ch\u1ecdn thu\u1ed1c c\u0169ng nh\u01b0 tr\u00e1nh c\u00e1c bi\u1ebfn ch\u1ee9ng kh\u00f4ng \u0111\u00e1ng c\u00f3 do thu\u1ed1c g\u00e2y ra.<\/strong><\/p>\n

1. Thu\u1ed1c kh\u00e1ng virus SARS-CoV-2<\/strong><\/h1>\n

* Nguy\u00ean t\u1eafc:\u00a0<\/em><\/strong><\/p>\n

\u0110\u1ed1i v\u1edbi thu\u1ed1c ch\u01b0a \u0111\u01b0\u1ee3c T\u1ed5 ch\u1ee9c y t\u1ebf th\u1ebf gi\u1edbi khuy\u1ebfn c\u00e1o s\u1eed d\u1ee5ng, ch\u01b0a \u0111\u01b0\u1ee3c c\u1ea5p ph\u00e9p l\u01b0u h\u00e0nh, ch\u01b0a \u0111\u01b0\u1ee3c c\u1ea5p ph\u00e9p s\u1eed d\u1ee5ng kh\u1ea9n c\u1ea5p t\u1ea1i b\u1ea5t k\u1ef3 n\u01b0\u1edbc n\u00e0o tr\u00ean th\u1ebf gi\u1edbi: vi\u1ec7c s\u1eed d\u1ee5ng ph\u1ea3i tu\u00e2n th\u1ee7 c\u00e1c quy \u0111\u1ecbnh v\u1ec1 th\u1eed nghi\u1ec7m l\u00e2m s\u00e0ng c\u1ee7a B\u1ed9 Y t\u1ebf.<\/p>\n

Thu\u1ed1c \u0111\u00e3 \u0111\u01b0\u1ee3c T\u1ed5 ch\u1ee9c y t\u1ebf th\u1ebf gi\u1edbi khuy\u1ebfn c\u00e1o s\u1eed d\u1ee5ng ho\u1eb7c \u0111\u01b0\u1ee3c c\u1ea5p ph\u00e9p l\u01b0u h\u00e0nh, ho\u1eb7c \u0111\u01b0\u1ee3c c\u1ea5p ph\u00e9p s\u1eed d\u1ee5ng kh\u1ea9n c\u1ea5p t\u1ea1i \u00edt nh\u1ea5t 1 n\u01b0\u1edbc tr\u00ean th\u1ebf gi\u1edbi th\u00ec c\u00f3 th\u1ec3 \u0111\u01b0\u1ee3c ch\u1ec9 \u0111\u1ecbnh \u0111i\u1ec1u tr\u1ecb theo di\u1ec5n bi\u1ebfn b\u1ec7nh l\u00fd c\u1ee7a ng\u01b0\u1eddi b\u1ec7nh (v\u00ed d\u1ee5: thu\u1ed1c remdesivir, favipiravir,…).<\/p>\n

1.1. Remdesivir<\/strong><\/p>\n

1.1.1. Ch\u1ec9 \u0111\u1ecbnh<\/strong><\/p>\n

    \n
  • Ng\u01b0\u1eddi b\u1ec7nh n\u1ed9i tr\u00fa, m\u1ee9c \u0111\u1ed9 nh\u1eb9 v\u00e0 c\u00f3 \u00edt nh\u1ea5t m\u1ed9t y\u1ebfu t\u1ed1 nguy c\u01a1 ti\u1ebfn tri\u1ec3n n\u1eb7ng; m\u1ee9c \u0111\u1ed9 trung b\u00ecnh v\u00e0 n\u1eb7ng, kh\u1edfi ph\u00e1t b\u1ec7nh ch\u01b0a qu\u00e1 10 ng\u00e0y c\u00f3 suy h\u00f4 h\u1ea5p ph\u1ea3i th\u1edf oxy, th\u1edf HFNC, th\u1edf m\u00e1y kh\u00f4ng x\u00e2m nh\u1eadp<\/li>\n
  • N\u00ean ph\u1ed1i h\u1ee3p v\u1edbi corticoid (\u01b0u ti\u00ean dexamethason).<\/li>\n
  • V\u1edbi c\u00e1c tr\u01b0\u1eddng h\u1ee3p \u0111\u00e3 \u0111\u01b0\u1ee3c \u0111i\u1ec1u tr\u1ecb b\u1eb1ng remdesivir tr\u01b0\u1edbc khi th\u1edf m\u00e1y x\u00e2m nh\u1eadp ho\u1eb7c ECMO th\u00ec c\u00f3 th\u1ec3 ti\u1ebfp t\u1ee5c d\u00f9ng remdesivir cho \u0111\u1ee7 li\u1ec7u tr\u00ecnh.<\/li>\n<\/ul>\n

    1.1.2. Ch\u1ed1ng ch\u1ec9 \u0111\u1ecbnh<\/strong><\/p>\n

      \n
    • Ti\u1ec1n s\u1eed qu\u00e1 m\u1eabn v\u1edbi b\u1ea5t k\u1ef3 th\u00e0nh ph\u1ea7n n\u00e0o trong c\u00f4ng th\u1ee9c thu\u1ed1c.<\/li>\n
    • Tr\u1ebb em < 12 tu\u1ed5i<\/li>\n
    • Ng\u01b0\u1eddi b\u1ec7nh c\u00f3 men gan ALT t\u0103ng tr\u00ean 5 l\u1ea7n gi\u1edbi h\u1ea1n tr\u00ean c\u1ee7a kho\u1ea3ng gi\u00e1 tr\u1ecb b\u00ecnh th\u01b0\u1eddng.<\/li>\n<\/ul>\n

      1.1.3. Li\u1ec1u d\u00f9ng<\/strong><\/p>\n

      Ng\u01b0\u1eddi \u2265 12 tu\u1ed5i v\u00e0 c\u00e2n n\u1eb7ng > 40kg: Ng\u00e0y \u0111\u1ea7u 200mg, nh\u1eefng ng\u00e0y sau 100mg\/ng\u00e0y, truy\u1ec1n t\u0129nh m\u1ea1ch 1 l\u1ea7n trong 30 – 120 ph\u00fat.<\/p>\n

      Th\u1eddi gian \u0111i\u1ec1u tr\u1ecb: 5 ng\u00e0y, n\u1ebfu kh\u00f4ng c\u1ea3i thi\u1ec7n v\u1ec1 l\u00e2m s\u00e0ng c\u00f3 th\u1ec3 \u0111i\u1ec1u tr\u1ecb th\u00eam 5 ng\u00e0y ti\u1ebfp.<\/p>\n

      1.1.4. Ch\u00fa \u00fd<\/strong><\/p>\n

        \n
      • Ph\u1ee5 n\u1eef c\u00f3 thai v\u00e0 nu\u00f4i con b\u1eb1ng s\u1eefa m\u1eb9: Ch\u01b0a c\u00f3 d\u1eef li\u1ec7u \u0111\u1ea7y \u0111\u1ee7. Kh\u00f4ng khuy\u1ebfn c\u00e1o tr\u1eeb tr\u01b0\u1eddng h\u1ee3p l\u1ee3i \u00edch v\u01b0\u1ee3t tr\u1ed9i so v\u1edbi nguy c\u01a1.<\/li>\n
      • Theo d\u00f5i ng\u01b0\u1eddi b\u1ec7nh trong th\u1eddi gian truy\u1ec1n v\u00e0 trong v\u00f2ng 1 h sau truy\u1ec1n \u0111\u1ec3 ph\u00e1t hi\u1ec7n v\u00e0 x\u1eed tr\u00ed k\u1ecbp th\u1eddi ph\u1ea3n v\u1ec7 v\u00e0 c\u00e1c ph\u1ea3n \u1ee9ng ti\u00eam truy\u1ec1n (n\u1ebfu c\u00f3).<\/li>\n
      • Theo d\u00f5i t\u0103ng men gan trong qu\u00e1 tr\u00ecnh s\u1eed d\u1ee5ng thu\u1ed1c. Ng\u01b0ng s\u1eed d\u1ee5ng thu\u1ed1c n\u1ebfu ALT t\u0103ng tr\u00ean 5 l\u1ea7n gi\u1edbi h\u1ea1n tr\u00ean b\u00ecnh th\u01b0\u1eddng trong qu\u00e1 tr\u00ecnh \u0111i\u1ec1u tr\u1ecb.<\/li>\n
      • Ch\u01b0a c\u00f3 \u0111\u1ee7 th\u00f4ng tin khuy\u1ebfn c\u00e1o s\u1eed d\u1ee5ng thu\u1ed1c cho ng\u01b0\u1eddi b\u1ec7nh c\u00f3 m\u1ee9c l\u1ecdc c\u1ea7u th\u1eadn \u01b0\u1edbc t\u00ednh eGFR < 30mL\/ph\u00fat).<\/li>\n
      • Th\u00f4ng tin chi ti\u1ebft th\u00eam v\u1ec1 thu\u1ed1c th\u1ef1c hi\u1ec7n theo t\u1edd h\u01b0\u1edbng d\u1eabn s\u1eed d\u1ee5ng thu\u1ed1c<\/li>\n<\/ul>\n
        \"\"
        Ngu\u1ed3n<\/strong>: Carey Students Model Pricing for Promising Drug, Remdesivir, for the Treatment of COVID-19<\/em><\/figcaption><\/figure>\n

        1.2. Favipiravir<\/strong><\/p>\n

        1.2.1. Ch\u1ec9 \u0111\u1ecbnh<\/strong><\/p>\n

        Ng\u01b0\u1eddi b\u1ec7nh COVID-19 m\u1ee9c \u0111\u1ed9 nh\u1eb9 c\u00f3 y\u1ebfu t\u1ed1 nguy c\u01a1 v\u00e0 m\u1ee9c \u0111\u1ed9 trung b\u00ecnh.<\/p>\n

        1.2.2. Ch\u1ed1ng ch\u1ec9 \u0111\u1ecbnh<\/strong><\/p>\n

          \n
        • Ph\u1ee5 n\u1eef c\u00f3 thai, ph\u1ee5 n\u1eef \u0111ang c\u00f3 k\u1ebf ho\u1ea1ch c\u00f3 thai.<\/li>\n
        • Ph\u1ee5 n\u1eef cho con b\u00fa<\/li>\n
        • D\u01b0\u1edbi 18 tu\u1ed5i<\/li>\n
        • Suy gan n\u1eb7ng, suy th\u1eadn n\u1eb7ng<\/li>\n<\/ul>\n

          1.2.3. Li\u1ec1u d\u00f9ng<\/strong><\/p>\n

          Li\u1ec1u d\u00f9ng: ng\u00e0y \u0111\u1ea7u u\u1ed1ng 1600mg\/l\u1ea7n x 2 l\u1ea7n\/ng\u00e0y, c\u00e1c ng\u00e0y sau u\u1ed1ng 600 mg\/l\u1ea7n x 2 l\u1ea7n\/ng\u00e0y<\/p>\n

          Th\u1eddi gian \u0111i\u1ec1u tr\u1ecb: 5-7 ng\u00e0y<\/p>\n

          1.2.4. Ch\u00fa \u00fd<\/strong><\/p>\n

            \n
          • Ch\u00fa \u00fd \u00edt nh\u1ea5t 2 ng\u00e0y \u0111\u1ea7u d\u00f9ng thu\u1ed1c do c\u00f3 th\u1ec3 g\u00e2y r\u1ed1i lo\u1ea1n t\u00e2m th\u1ea7n<\/li>\n
          • Th\u1eadn tr\u1ecdng \u1edf ng\u01b0\u1eddi b\u1ec7nh c\u00f3 ti\u1ec1n s\u1eed gout v\u00ec c\u00f3 th\u1ec3 l\u00e0m t\u0103ng acid uric v\u00e0 l\u00e0m n\u1eb7ng th\u00eam b\u1ec7nh<\/li>\n
          • Th\u00f4ng tin chi ti\u1ebft th\u00eam v\u1ec1 thu\u1ed1c th\u1ef1c hi\u1ec7n theo t\u1edd h\u01b0\u1edbng d\u1eabn s\u1eed d\u1ee5ng thu\u1ed1c<\/li>\n<\/ul>\n
            \"\"
            Ngu\u1ed3n<\/strong>: Favipiravir to be investigated as a possible COVID-19 treatment for at-home recovery in the PRINCIPLE trial<\/em><\/figcaption><\/figure>\n

            1.3. Nirmatrelvir k\u1ebft h\u1ee3p v\u1edbi Ritonavir<\/strong><\/p>\n

            1.3.1. Ch\u1ec9 \u0111\u1ecbnh<\/strong><\/p>\n

            Ng\u01b0\u1eddi b\u1ec7nh COVID-19 ng\u01b0\u1eddi l\u1edbn v\u00e0 tr\u1ebb em t\u1eeb 12 tu\u1ed5i tr\u1edf l\u00ean c\u00f3 c\u00e2n n\u1eb7ng \u00edt nh\u1ea5t 40kg m\u1ee9c \u0111\u1ed9 nh\u1eb9, trung b\u00ecnh v\u00e0 c\u00f3 \u00edt nh\u1ea5t 1 nguy c\u01a1 cao ti\u1ebfn tri\u1ec3n th\u00e0nh b\u1ec7nh n\u1eb7ng (bao g\u1ed3m nh\u1eadp vi\u1ec7n v\u00e0 t\u1eed vong). S\u1eed d\u1ee5ng trong v\u00f2ng 5 ng\u00e0y k\u1ec3 t\u1eeb khi kh\u1edfi ph\u00e1t c\u00e1c tri\u1ec7u ch\u1ee9ng ho\u1eb7c khi c\u00f3 x\u00e9t nghi\u1ec7m d\u01b0\u01a1ng t\u00ednh v\u1edbi virus SARS-CoV-2.<\/p>\n

            1.3.2. Ch\u1ed1ng ch\u1ec9 \u0111\u1ecbnh<\/strong><\/p>\n

            Ti\u1ec1n s\u1eed d\u1ecb \u1ee9ng (v\u00ed d\u1ee5, ho\u1ea1i t\u1eed bi\u1ec3u b\u00ec nhi\u1ec5m \u0111\u1ed9c [TEN], h\u1ed9i ch\u1ee9ng Stevens-Johnson [SJS]) v\u1edbi nirmatrelvir ho\u1eb7c ritonavir.<\/p>\n

            1.3.3. Li\u1ec1u d\u00f9ng<\/strong><\/p>\n

            Li\u1ec1u d\u00f9ng: 300mg nirmatrelvir u\u1ed1ng \u0111\u1ed3ng th\u1eddi c\u00f9ng 100mg ritonavir, x 2 l\u1ea7n\/ng\u00e0y.<\/p>\n

            Th\u1eddi gian \u0111i\u1ec1u tr\u1ecb: 05 ng\u00e0y.<\/p>\n

            1.3.4. Ch\u00fa \u00fd<\/strong><\/p>\n

              \n
            • Th\u00f4ng tin chi ti\u1ebft th\u00eam v\u1ec1 thu\u1ed1c th\u1ef1c hi\u1ec7n theo t\u1edd h\u01b0\u1edbng d\u1eabn s\u1eed d\u1ee5ng thu\u1ed1c<\/li>\n
            • Ch\u00fa \u00fd c\u00e1c t\u01b0\u01a1ng t\u00e1c thu\u1ed1c nghi\u00eam tr\u1ecdng ho\u1eb7c ch\u1ed1ng ch\u1ec9 \u0111\u1ecbnh th\u00f4ng qua \u1ee9c ch\u1ebf CYP3A4<\/li>\n
            • Kh\u00f4ng khuy\u1ebfn c\u00e1o s\u1eed d\u1ee5ng cho ng\u01b0\u1eddi b\u1ec7nh suy gan n\u1eb7ng, suy th\u1eadn n\u1eb7ng<\/li>\n<\/ul>\n
              \"\"
              \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0Ngu\u1ed3n<\/strong>: Paxlovid (nirmatrelvir and ritonavir) for the Treatment of COVID-19<\/figcaption><\/figure>\n

              1.4. <\/strong>Molnupiravir<\/strong><\/p>\n

              1.4.1. Ch\u1ec9 \u0111\u1ecbnh<\/strong><\/p>\n

              \u0110i\u1ec1u tr\u1ecb b\u1ec7nh COVID 19 t\u1eeb nh\u1eb9 \u0111\u1ebfn trung b\u00ecnh 2019 \u1edf ng\u01b0\u1eddi l\u1edbn c\u00f3 nguy c\u01a1 cao ti\u1ebfn tri\u1ec3n n\u1eb7ng c\u1ee7a virus SARS-CoV-2.<\/p>\n

              1.4.2. Ch\u1ed1ng ch\u1ec9 \u0111\u1ecbnh<\/strong><\/p>\n

              Hi\u1ec7n t\u1ea1i c\u00e1c d\u1eef li\u1ec7u c\u00f2n h\u1ea1n ch\u1ebf trong khy\u1ebfn c\u00e1o v\u1ec1 ch\u1ed1ng ch\u1ec9 \u0111\u1ecbnh.<\/p>\n

              1.4.3. Li\u1ec1u d\u00f9ng<\/strong><\/p>\n

                \n
              • 800mg u\u1ed1ng m\u1ed7i 12 gi\u1edd trong 5 ng\u00e0y<\/li>\n
              • B\u1eaft \u0111\u1ea7u c\u00e0ng s\u1edbm c\u00e0ng t\u1ed1t sau khi \u0111\u01b0\u1ee3c ch\u1ea9n \u0111o\u00e1n m\u1eafc COVID-19 v\u00e0 trong v\u00f2ng 5 ng\u00e0y k\u1ec3 t\u1eeb khi kh\u1edfi ph\u00e1t tri\u1ec7u ch\u1ee9ng. Ho\u00e0n th\u00e0nh to\u00e0n b\u1ed9 li\u1ec7u tr\u00ecnh \u0111i\u1ec1u tr\u1ecb k\u00e9o d\u00e0i 5 ng\u00e0y v\u00e0 ti\u1ebfp t\u1ee5c c\u00e1ch ly theo c\u00e1c khuy\u1ebfn c\u00e1o.<\/li>\n
              • N\u1ebfu b\u1ec7nh nh\u00e2n nh\u1eadp vi\u1ec7n do nhi\u1ec5m COVID-19 nghi\u00eam tr\u1ecdng ho\u1eb7c nguy k\u1ecbch sau khi b\u1eaft \u0111\u1ea7u \u0111i\u1ec1u tr\u1ecb b\u1eb1ng molnupiravir, vi\u1ec7c ti\u1ebfp t\u1ee5c \u0111i\u1ec1u tr\u1ecb \u0111\u1ee7 5 ng\u00e0y s\u1ebd ph\u1ee5 thu\u1ed9c v\u00e0o B\u00e1c s\u0129 \u0111i\u1ec1u tr\u1ecb.<\/li>\n<\/ul>\n

                1.4.4. Ch\u00fa \u00fd<\/strong><\/p>\n

                  \n
                • C\u00f3 th\u1ec3 g\u00e2y h\u1ea1i cho thai nhi khi d\u00f9ng cho ph\u1ee5 n\u1eef mang thai.<\/li>\n
                • \u0110\u1ed9c t\u00ednh x\u01b0\u01a1ng v\u00e0 s\u1ee5n. Do \u0111\u00f3, kh\u00f4ng \u0111\u01b0\u1ee3c ph\u00e9p s\u1eed d\u1ee5ng cho b\u1ec7nh nh\u00e2n d\u01b0\u1edbi 18 tu\u1ed5i do c\u00f3 th\u1ec3 \u1ea3nh h\u01b0\u1edfng \u0111\u1ebfn s\u1ef1 ph\u00e1t tri\u1ec3n c\u1ee7a x\u01b0\u01a1ng v\u00e0 s\u1ee5n.<\/li>\n
                • C\u00e2n nh\u1eafc vi\u1ec7c ng\u1eebng cho con b\u00fa, \u0111\u1ed3ng th\u1eddi c\u00e2n nh\u1eafc v\u1eaft v\u00e0 b\u1ecf s\u1eefa m\u1eb9 trong khi \u0111i\u1ec1u tr\u1ecb v\u00e0 trong 4 ng\u00e0y sau li\u1ec1u cu\u1ed1i c\u00f9ng<\/li>\n<\/ul>\n
                  \"\"
                  \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 Ngu\u1ed3n<\/strong>: What you should know about molnupiravir – Vinmec<\/em><\/figcaption><\/figure>\n

                  2. Kh\u00e1ng th\u1ec3 kh\u00e1ng virus SARS-CoV-2<\/strong><\/h2>\n

                  \u0110\u1ed1i v\u1edbi thu\u1ed1c ch\u01b0a \u0111\u01b0\u1ee3c T\u1ed5 ch\u1ee9c y t\u1ebf th\u1ebf gi\u1edbi khuy\u1ebfn c\u00e1o s\u1eed d\u1ee5ng, ch\u01b0a \u0111\u01b0\u1ee3c c\u1ea5p ph\u00e9p l\u01b0u h\u00e0nh, ch\u01b0a \u0111\u01b0\u1ee3c c\u1ea5p ph\u00e9p s\u1eed d\u1ee5ng kh\u1ea9n c\u1ea5p t\u1ea1i b\u1ea5t k\u1ef3 n\u01b0\u1edbc n\u00e0o tr\u00ean th\u1ebf gi\u1edbi: vi\u1ec7c s\u1eed d\u1ee5ng ph\u1ea3i tu\u00e2n th\u1ee7 c\u00e1c quy \u0111\u1ecbnh v\u1ec1 th\u1eed nghi\u1ec7m l\u00e2m s\u00e0ng c\u1ee7a B\u1ed9 Y t\u1ebf.<\/p>\n

                  Thu\u1ed1c \u0111\u00e3 \u0111\u01b0\u1ee3c T\u1ed5 ch\u1ee9c y t\u1ebf th\u1ebf gi\u1edbi khuy\u1ebfn c\u00e1o s\u1eed d\u1ee5ng ho\u1eb7c \u0111\u01b0\u1ee3c c\u1ea5p ph\u00e9p l\u01b0u h\u00e0nh, ho\u1eb7c \u0111\u01b0\u1ee3c c\u1ea5p ph\u00e9p s\u1eed d\u1ee5ng kh\u1ea9n c\u1ea5p t\u1ea1i \u00edt nh\u1ea5t 1 n\u01b0\u1edbc tr\u00ean th\u1ebf gi\u1edbi th\u00ec c\u00f3 th\u1ec3 \u0111\u01b0\u1ee3c ch\u1ec9 \u0111\u1ecbnh \u0111i\u1ec1u tr\u1ecb theo di\u1ec5n bi\u1ebfn b\u1ec7nh l\u00fd c\u1ee7a ng\u01b0\u1eddi b\u1ec7nh (v\u00ed d\u1ee5: thu\u1ed1c casirivimab 600 mg + imdevimab 600 mg, bamlanivimab + etesevimab,…).<\/p>\n

                  2.1. Casirivimab 600 mg + Imdevimab<\/strong> 600 mg<\/strong><\/p>\n

                  2.1.1. Ch\u1ec9 \u0111\u1ecbnh<\/strong><\/p>\n

                  B\u1ec7nh kh\u1edfi ph\u00e1t d\u01b0\u1edbi 10 ng\u00e0y v\u1edbi m\u1ee9c \u0111\u1ed9 b\u1ec7nh nh\u1eb9 \u0111\u1ebfn trung b\u00ecnh v\u00e0 c\u00f3 nguy c\u01a1 ti\u1ebfn tri\u1ec3n l\u00ean m\u1ee9c \u0111\u1ed9 n\u1eb7ng c\u1ee7a virus SARS-CoV-2.<\/p>\n

                  2.1.2. Ch\u1ed1ng ch\u1ec9 \u0111\u1ecbnh<\/strong><\/p>\n

                    \n
                  • Ng\u01b0\u1eddi d\u01b0\u1edbi 40kg. Tr\u1ebb em < 12 tu\u1ed5i ho\u1eb7c tr\u1ebb em < 40kg<\/li>\n
                  • Ph\u1ee5 n\u1eef c\u00f3 thai v\u00e0 cho con b\u00fa<\/li>\n<\/ul>\n

                    2.1.3. Li\u1ec1u d\u00f9ng<\/strong><\/p>\n

                    Casirivimab 600 mg + Imdevimab 600 mg truy\u1ec1n t\u0129nh m\u1ea1ch m\u1ed9t l\u1ea7n trong 30 ph\u00fat. (c\u00f3 th\u1ec3 ti\u00eam d\u01b0\u1edbi da \u00bc li\u1ec1u tr\u00ean trong tr\u01b0\u1eddng h\u1ee3p kh\u00f4ng truy\u1ec1n \u0111\u01b0\u1ee3c t\u0129nh m\u1ea1ch).<\/p>\n

                    Th\u1eddi gian \u0111i\u1ec1u tr\u1ecb: D\u00f9ng m\u1ed9t li\u1ec1u duy nh\u1ea5t<\/p>\n

                    2.1.4. Ch\u00fa \u00fd<\/strong><\/p>\n

                    WHO, FDA khuy\u1ebfn c\u00e1o theo d\u00f5i 1 gi\u1edd sau khi k\u1ebft th\u00fac truy\u1ec1n<\/p>\n

                    \"\"
                    \u00a0 \u00a0 \u00a0 \u00a0Ngu\u1ed3n<\/strong>: Roche\u2019s antibody Covid drug now available in India<\/em><\/figcaption><\/figure>\n

                    2.2. Bamlanivimab 700mg + Etesevimab 1400mg<\/strong><\/p>\n

                    2.2.1. Ch\u1ec9 \u0111\u1ecbnh<\/strong><\/p>\n

                    B\u1ec7nh kh\u1edfi ph\u00e1t d\u01b0\u1edbi 10 ng\u00e0y v\u1edbi m\u1ee9c \u0111\u1ed9 b\u1ec7nh nh\u1eb9 \u0111\u1ebfn trung b\u00ecnh v\u00e0 c\u00f3 nguy c\u01a1 ti\u1ebfn tri\u1ec3n l\u00ean m\u1ee9c \u0111\u1ed9 n\u1eb7ng c\u1ee7a virus SARS-CoV-2.<\/p>\n

                    2.2.2. Ch\u1ed1ng ch\u1ec9 \u0111\u1ecbnh<\/strong><\/p>\n

                      \n
                    • Tr\u1ebb em < 12 tu\u1ed5i<\/li>\n
                    • C\u00e2n n\u1eb7ng < 40kg<\/li>\n<\/ul>\n

                      2.2.3. Li\u1ec1u d\u00f9ng<\/strong><\/p>\n

                      Th\u1eddi gian \u0111i\u1ec1u tr\u1ecb: D\u00f9ng m\u1ed9t li\u1ec1u duy nh\u1ea5t<\/p>\n

                      2.2.4. Ch\u00fa \u00fd<\/strong><\/p>\n

                      FDA khuy\u1ebfn c\u00e1o: h\u01b0\u1edbng d\u1eabn s\u1eed d\u1ee5ng theo FDA theo d\u00f5i 1 gi\u1edd sau khi k\u1ebft th\u00fac truy\u1ec1n<\/p>\n

                      \"\"
                      Ngu\u1ed3n<\/strong>: Antibody treatments going unused in Washington state<\/em><\/figcaption><\/figure>\n

                      2.3. Sotrovimab<\/strong><\/p>\n

                      2.3.1. Ch\u1ec9 \u0111\u1ecbnh<\/strong><\/p>\n

                      B\u1ec7nh kh\u1edfi ph\u00e1t d\u01b0\u1edbi 10 ng\u00e0y v\u1edbi m\u1ee9c \u0111\u1ed9 b\u1ec7nh nh\u1eb9 \u0111\u1ebfn trung b\u00ecnh v\u00e0 c\u00f3 nguy c\u01a1 ti\u1ebfn tri\u1ec3n l\u00ean m\u1ee9c \u0111\u1ed9 n\u1eb7ng c\u1ee7a virus SARS-CoV-2.<\/p>\n

                      2.3.2. Ch\u1ed1ng ch\u1ec9 \u0111\u1ecbnh<\/strong><\/p>\n

                      Tr\u1ebb em < 12 tu\u1ed5i<\/p>\n

                      C\u00e2n n\u1eb7ng < 40kg<\/p>\n

                      2.3.3. Li\u1ec1u d\u00f9ng<\/strong><\/p>\n

                      Sotrovimab 500 mg truy\u1ec1n t\u0129nh m\u1ea1ch m\u1ed9t l\u1ea7n trong 30 ph\u00fat.<\/p>\n

                      Th\u1eddi gian \u0111i\u1ec1u tr\u1ecb: D\u00f9ng m\u1ed9t li\u1ec1u duy nh\u1ea5t<\/p>\n

                      2.3.4. Ch\u00fa \u00fd<\/strong><\/p>\n

                      FDA khuy\u1ebfn c\u00e1o, theo d\u00f5i 1 gi\u1edd sau khi k\u1ebft th\u00fac truy\u1ec1n<\/p>\n

                      \"\"
                      Ngu\u1ed3n<\/strong>: WHO recommends\u202ftwo\u202fnew drugs to treat patients with COVID-19\u202f\u202f<\/em><\/figcaption><\/figure>\n

                      3. Thu\u1ed1c \u1ee9c ch\u1ebf Interleukin-6<\/strong><\/h3>\n

                      \u0110\u1ed1i v\u1edbi thu\u1ed1c ch\u01b0a \u0111\u01b0\u1ee3c T\u1ed5 ch\u1ee9c y t\u1ebf th\u1ebf gi\u1edbi khuy\u1ebfn c\u00e1o s\u1eed d\u1ee5ng, ch\u01b0a \u0111\u01b0\u1ee3c c\u1ea5p ph\u00e9p l\u01b0u h\u00e0nh, ch\u01b0a \u0111\u01b0\u1ee3c c\u1ea5p ph\u00e9p s\u1eed d\u1ee5ng kh\u1ea9n c\u1ea5p t\u1ea1i b\u1ea5t k\u1ef3 n\u01b0\u1edbc n\u00e0o tr\u00ean th\u1ebf gi\u1edbi: vi\u1ec7c s\u1eed d\u1ee5ng ph\u1ea3i tu\u00e2n th\u1ee7 c\u00e1c quy \u0111\u1ecbnh v\u1ec1 th\u1eed nghi\u1ec7m l\u00e2m s\u00e0ng c\u1ee7a B\u1ed9 Y t\u1ebf.<\/p>\n

                      Thu\u1ed1c \u0111\u00e3 \u0111\u01b0\u1ee3c T\u1ed5 ch\u1ee9c y t\u1ebf th\u1ebf gi\u1edbi khuy\u1ebfn c\u00e1o s\u1eed d\u1ee5ng ho\u1eb7c \u0111\u01b0\u1ee3c c\u1ea5p ph\u00e9p l\u01b0u h\u00e0nh, ho\u1eb7c \u0111\u01b0\u1ee3c c\u1ea5p ph\u00e9p s\u1eed d\u1ee5ng kh\u1ea9n c\u1ea5p t\u1ea1i \u00edt nh\u1ea5t 1 n\u01b0\u1edbc tr\u00ean th\u1ebf gi\u1edbi th\u00ec c\u00f3 th\u1ec3 \u0111\u01b0\u1ee3c ch\u1ec9 \u0111\u1ecbnh \u0111i\u1ec1u tr\u1ecb theo di\u1ec5n bi\u1ebfn b\u1ec7nh l\u00fd c\u1ee7a ng\u01b0\u1eddi b\u1ec7nh nhi\u1ec5m virus SARS-CoV-2(v\u00ed d\u1ee5: thu\u1ed1c tocilizumab,…).<\/p>\n

                      * Tocilizumab<\/strong><\/p>\n

                      3.1. Ch\u1ec9 \u0111\u1ecbnh<\/strong><\/p>\n

                        \n
                      • B\u1ec7nh COVID-19 \u0111i\u1ec1u tr\u1ecb n\u1ed9i tr\u00fa nh\u1eadp vi\u1ec7n trong v\u00f2ng 3 ng\u00e0y, c\u00f3 suy h\u00f4 h\u1ea5p ph\u1ea3i th\u1edf oxy, th\u1edf HFNC, ho\u1eb7c th\u1edf m\u00e1y kh\u00f4ng x\u00e2m nh\u1eadp v\u00e0 c\u00f3 CRP \u2265 75 mg\/L.<\/li>\n
                      • B\u1ec7nh COVID-19 \u0111i\u1ec1u tr\u1ecb n\u1ed9i tr\u00fa nh\u1eadp vi\u1ec7n trong v\u00f2ng 24 gi\u1edd c\u1ea7n th\u1edf m\u00e1y x\u00e2m nh\u1eadp.<\/li>\n<\/ul>\n

                        3.2. Ch\u1ed1ng ch\u1ec9 \u0111\u1ecbnh<\/strong><\/p>\n

                          \n
                        • Ng\u01b0\u1eddi b\u1ec7nh suy gi\u1ea3m mi\u1ec5n d\u1ecbch, BC trung t\u00ednh < 0,5 G\/L<\/li>\n
                        • T\u0103ng enzym ALT > 5 l\u1ea7n gi\u00e1 tr\u1ecb gi\u1edbi h\u1ea1n tr\u00ean c\u1ee7a kho\u1ea3ng gi\u00e1 tr\u1ecb b\u00ecnh th\u01b0\u1eddng<\/li>\n
                        • TC < 50 G\/L<\/li>\n<\/ul>\n

                          3.3. Li\u1ec1u d\u00f9ng<\/strong><\/p>\n

                            \n
                          • C\u00e2n n\u1eb7ng \u226530 kg: 8 mg\/kg, truy\u1ec1n t\u0129nh m\u1ea1ch m\u1ed9t l\u1ea7n trong v\u00f2ng 60 ph\u00fat, li\u1ec1u t\u1ed1i \u0111a 800 mg.<\/li>\n
                          • C\u00e2n n\u1eb7ng < 30 kg: 12mg\/kg, truy\u1ec1n t\u0129nh m\u1ea1ch m\u1ed9t l\u1ea7n trong v\u00f2ng 60 ph\u00fat.<\/li>\n
                          • Sau 8h n\u1ebfu kh\u00f4ng c\u1ea3i thi\u1ec7n tri\u1ec7u ch\u1ee9ng c\u00f3 th\u1ec3 d\u00f9ng li\u1ec1u th\u1ee9 2.<\/li>\n<\/ul>\n

                            3.4. Ch\u00fa \u00fd<\/strong><\/p>\n

                            Kh\u00f4ng d\u00f9ng tocilizumab \u0111\u01a1n \u0111\u1ed9c, k\u1ebft h\u1ee3p dexamethaxon 6mg ho\u1eb7c corticoid li\u1ec1u t\u01b0\u01a1ng \u0111\u01b0\u01a1ng.<\/p>\n

                            \"\"
                            \u00a0Ngu\u1ed3n<\/strong>: Arthritis Drug Tocilizumab Gets FDA EUA for Severe COVID-19<\/em><\/figcaption><\/figure>\n

                            Ngu\u1ed3n<\/strong>:<\/p>\n

                            H\u01b0\u1edbng d\u1eabn ch\u1ea9n \u0111o\u00e1n v\u00e0 \u0111i\u1ec1u tr\u1ecb COVID 19 c\u1ee7a B\u1ed9 Y t\u1ebf 2022.<\/p>\n

                            Medscape: Nirmatrelvir\/Ritonavir (Investigational).<\/p>\n

                            Medscape: molnupiravir (Investigational).<\/p>\n","protected":false},"excerpt":{"rendered":"

                            C\u00e1c nh\u00e0 khoa h\u1ecdc v\u00e0 c\u00e1c t\u1ed5 ch\u1ee9c y t\u1ebf tr\u00ean to\u00e0n th\u1ebf gi\u1edbi \u0111ang ti\u1ebfp t\u1ee5c nghi\u00ean c\u1ee9u v\u1ec1 virus SARS-CoV-2 v\u00e0 COVID-19 \u0111\u1ec3 t\u00ecm ra c\u00e1c thu\u1ed1c\u00a0 \u0111i\u1ec1u tr\u1ecb v\u00e0 ph\u01b0\u01a1ng ph\u00e1p d\u1ef1 ph\u00f2ng . Trong \u0111\u00f3 ,l\u00e0 s\u1ef1 ra \u0111\u1eddi c\u1ee7a c\u00e1c nh\u00f3m thu\u1ed1c \u0111i\u1ec1u tr\u1ecb COVID 19 . Vi\u1ec7c n\u1eafm v\u1eefng […]<\/p>\n","protected":false},"author":4,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[20,33],"tags":[3],"yoast_head":"\nC\u00e1c nh\u00f3m thu\u1ed1c \u0111i\u1ec1u tr\u1ecb virus SARS-CoV-2 - Vinmec<\/title>\n<meta name=\"description\" content=\"C\u00e1c nh\u00e0 khoa h\u1ecdc v\u00e0 c\u00e1c t\u1ed5 ch\u1ee9c y t\u1ebf tr\u00ean to\u00e0n th\u1ebf gi\u1edbi \u0111ang ti\u1ebfp t\u1ee5c nghi\u00ean c\u1ee9u v\u1ec1 virus SARS-CoV-2 v\u00e0 COVID-19 \u0111\u1ec3 t\u00ecm ra c\u00e1c thu\u1ed1c\" \/>\n<meta name=\"robots\" content=\"noindex, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"C\u00e1c nh\u00f3m thu\u1ed1c \u0111i\u1ec1u tr\u1ecb virus SARS-CoV-2 - Vinmec\" \/>\n<meta property=\"og:description\" content=\"C\u00e1c nh\u00e0 khoa h\u1ecdc v\u00e0 c\u00e1c t\u1ed5 ch\u1ee9c y t\u1ebf tr\u00ean to\u00e0n th\u1ebf gi\u1edbi \u0111ang ti\u1ebfp t\u1ee5c nghi\u00ean c\u1ee9u v\u1ec1 virus SARS-CoV-2 v\u00e0 COVID-19 \u0111\u1ec3 t\u00ecm ra c\u00e1c thu\u1ed1c\" \/>\n<meta property=\"og:url\" content=\"http:\/\/noithathoaphat.in\/ctv\/index.php\/2023\/04\/16\/sars-cov-2\/\" \/>\n<meta property=\"og:site_name\" content=\"Vinmec\" \/>\n<meta property=\"article:published_time\" content=\"2023-04-16T01:48:13+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2023-04-17T06:01:34+00:00\" \/>\n<meta property=\"og:image\" content=\"http:\/\/noithathoaphat.in\/ctv\/wp-content\/uploads\/2023\/04\/10-5.jpg\" \/>\n<meta name=\"author\" content=\"tdan tdan\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"tdan tdan\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"10 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"http:\/\/noithathoaphat.in\/ctv\/index.php\/2023\/04\/16\/sars-cov-2\/\",\"url\":\"http:\/\/noithathoaphat.in\/ctv\/index.php\/2023\/04\/16\/sars-cov-2\/\",\"name\":\"C\u00e1c nh\u00f3m thu\u1ed1c \u0111i\u1ec1u tr\u1ecb virus SARS-CoV-2 - 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