{"id":21243,"date":"2023-04-15T00:26:37","date_gmt":"2023-04-14T17:26:37","guid":{"rendered":"http:\/\/noithathoaphat.in\/ctv\/?p=21243"},"modified":"2023-05-16T00:44:07","modified_gmt":"2023-05-15T17:44:07","slug":"tac-dung-phu-chinh-cua-thuoc-chen-beta","status":"publish","type":"post","link":"http:\/\/noithathoaphat.in\/ctv\/index.php\/2023\/04\/15\/tac-dung-phu-chinh-cua-thuoc-chen-beta\/","title":{"rendered":"T\u00e1c d\u1ee5ng ph\u1ee5 ch\u00ednh c\u1ee7a thu\u1ed1c ch\u1eb9n beta"},"content":{"rendered":"<p><strong>H\u1ea7u h\u1ebft c\u00e1c t\u00e1c d\u1ee5ng ph\u1ee5 ch\u00ednh c\u1ee7a thu\u1ed1c ch\u1eb9n beta l\u00e0 do phong t\u1ecfa th\u1ee5 th\u1ec3 beta-adrenoreceptor. Do \u0111\u00f3, nhi\u1ec1u d\u1ea5u hi\u1ec7u v\u00e0 tri\u1ec7u ch\u1ee9ng c\u00f3 th\u1ec3 \u0111\u01b0\u1ee3c t\u1ea1o ra do c\u00e1c th\u1ee5 th\u1ec3 beta \u1ea3nh h\u01b0\u1edfng \u0111\u1ebfn nhi\u1ec1u ch\u1ee9c n\u0103ng sinh l\u00fd v\u00e0 trao \u0111\u1ed5i ch\u1ea5t. C\u00e1c ph\u1ea3n \u1ee9ng kh\u00e1c d\u01b0\u1eddng nh\u01b0 kh\u00f4ng li\u00ean quan \u0111\u1ebfn phong t\u1ecfa beta c\u00f3 th\u1ec3 x\u1ea3y ra, nh\u01b0ng ch\u00fang kh\u00f4ng ph\u1ed5 bi\u1ebfn. C\u00e1c t\u00e1c d\u1ee5ng ch\u00ednh \u0111\u1ed1i v\u1edbi tim do phong t\u1ecfa beta bao g\u1ed3m tr\u1ea7m tr\u1ecdng th\u00eam t\u00ecnh tr\u1ea1ng suy tim sung huy\u1ebft v\u00e0 l\u00e0m ch\u1eadm nh\u1ecbp tim.\u00a0<\/strong><\/p>\n<h2>1. T\u00e1c d\u1ee5ng ph\u1ee5 v\u1ec1 tim c\u1ee7a thu\u1ed1c ch\u1eb9n beta<\/h2>\n<p>C\u00e1c t\u00e1c d\u1ee5ng ch\u00ednh \u0111\u1ed1i v\u1edbi tim do phong t\u1ecfa beta bao g\u1ed3m tr\u1ea7m tr\u1ecdng th\u00eam t\u00ecnh tr\u1ea1ng suy tim sung huy\u1ebft v\u00e0 l\u00e0m ch\u1eadm nh\u1ecbp tim<\/p>\n<h3>1.1. <strong>Suy tim <\/strong><\/h3>\n<p>Thu\u1ed1c ch\u1eb9n beta l\u00e0 m\u1ed9t th\u00e0nh ph\u1ea7n quan tr\u1ecdng trong li\u1ec7u ph\u00e1p d\u00e0i h\u1ea1n \u0111\u1ed1i v\u1edbi b\u1ec7nh nh\u00e2n <a href=\"https:\/\/www.vinmec.com\/vi\/benh\/suy-tim-3262\/\">suy tim<\/a> m\u1ea1n t\u00ednh v\u00e0 gi\u1ea3m ch\u1ee9c n\u0103ng t\u00e2m thu th\u1ea5t tr\u00e1i, v\u00ec nh\u1eefng thu\u1ed1c n\u00e0y l\u00e0m gi\u1ea3m t\u00e1c d\u1ee5ng b\u1ea5t l\u1ee3i c\u1ee7a vi\u1ec7c k\u00edch th\u00edch qu\u00e1 m\u1ee9c catecholamine m\u1ea1n t\u00ednh. Tuy nhi\u00ean, thu\u1ed1c ch\u1eb9n beta c\u00f3 th\u1ec3 l\u00e0m tr\u1ea7m tr\u1ecdng th\u00eam c\u00e1c tri\u1ec7u ch\u1ee9ng \u1edf b\u1ec7nh nh\u00e2n suy tim m\u1ea5t b\u00f9 c\u1ea5p t\u00ednh ho\u1eb7c \u1edf nh\u1eefng ng\u01b0\u1eddi c\u00f3 r\u1ed1i lo\u1ea1n ch\u1ee9c n\u0103ng c\u01a1 tim t\u1eeb tr\u01b0\u1edbc v\u00e0 kh\u1ea3 n\u0103ng b\u00f9 tr\u1eeb \u1edf m\u1ee9c gi\u1edbi h\u1ea1n, v\u00ec vi\u1ec7c duy tr\u00ec cung l\u01b0\u1ee3ng tim \u1edf nh\u1eefng b\u1ec7nh nh\u00e2n n\u00e0y ph\u1ee5 thu\u1ed9c m\u1ed9t ph\u1ea7n v\u00e0o s\u1ef1 \u0111i\u1ec1u khi\u1ec3n giao c\u1ea3m. Do \u0111\u00f3, thu\u1ed1c ch\u1eb9n beta kh\u00f4ng n\u00ean \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng nh\u01b0 m\u1ed9t li\u1ec7u ph\u00e1p m\u1edbi cho \u0111\u1ebfn khi suy tim \u0111\u01b0\u1ee3c ki\u1ec3m so\u00e1t. Tuy nhi\u00ean, nh\u1eefng b\u1ec7nh nh\u00e2n \u0111\u00e3 d\u00f9ng thu\u1ed1c ch\u1eb9n beta c\u00f3 th\u1ec3 ti\u1ebfp t\u1ee5c \u0111i\u1ec1u tr\u1ecb b\u1eb1ng li\u1ec7u ph\u00e1p n\u00e0y n\u1ebfu b\u1ecb suy tim m\u1ea5t b\u00f9.<\/p>\n<p>T\u0103ng s\u1ee9c c\u1ea3n m\u1ea1ch m\u00e1u ngo\u1ea1i vi, g\u00e2y ra b\u1edfi thu\u1ed1c ch\u1eb9n beta kh\u00f4ng ch\u1ecdn l\u1ecdc, c\u0169ng c\u00f3 th\u1ec3 g\u00f3p ph\u1ea7n l\u00e0m suy gi\u1ea3m ch\u1ee9c n\u0103ng c\u01a1 tim trong b\u1ed1i c\u1ea3nh n\u00e0y. M\u1eb7t kh\u00e1c, c\u00e1c lo\u1ea1i thu\u1ed1c c\u00f3 ho\u1ea1t t\u00ednh giao c\u1ea3m n\u1ed9i t\u1ea1i (ISA), ch\u1eb3ng h\u1ea1n nh\u01b0 pindolol , c\u00f3 th\u1ec3 \u00edt l\u00e0m suy gi\u1ea3m ch\u1ee9c n\u0103ng c\u01a1 tim h\u01a1n.<\/p>\n<p>M\u1ed9t m\u1ed1i quan t\u00e2m kh\u00e1c v\u1ec1 thu\u1ed1c ch\u1eb9n beta \u1edf b\u1ec7nh nh\u00e2n suy tim l\u00e0 s\u1ef1 xu\u1ea5t hi\u1ec7n c\u1ee7a c\u00e1c tri\u1ec7u ch\u1ee9ng kh\u00e1c, bao g\u1ed3m ch\u00f3ng m\u1eb7t do h\u1ea1 huy\u1ebft \u00e1p v\u00e0 nh\u1ecbp tim ch\u1eadm.<\/p>\n<h3><strong>1.2. T\u00e1c d\u1ee5ng ph\u1ee5 l\u00e0m ch\u1eadm nh\u1ecbp tim\u00a0<\/strong><\/h3>\n<p>L\u00e0m ch\u1eadm nh\u1ecbp tim khi ngh\u1ec9 ng\u01a1i v\u00e0 ph\u00e1t tri\u1ec3n nh\u1ecbp tim ch\u1eadm xoang l\u00e0 m\u1ed9t ph\u1ea3n \u1ee9ng b\u00ecnh th\u01b0\u1eddng \u0111\u1ed1i v\u1edbi vi\u1ec7c \u0111i\u1ec1u tr\u1ecb b\u1eb1ng thu\u1ed1c ch\u1eb9n beta. Hi\u1ec7u \u1ee9ng n\u00e0y \u00edt n\u1ed5i b\u1eadt h\u01a1n v\u1edbi c\u00e1c lo\u1ea1i thu\u1ed1c c\u00f3 ISA. Tuy nhi\u00ean, t\u1ea5t c\u1ea3 c\u00e1c thu\u1ed1c ch\u1eb9n beta \u0111\u1ec1u t\u01b0\u01a1ng \u0111\u1ed1i ch\u1ed1ng ch\u1ec9 \u0111\u1ecbnh \u1edf nh\u1eefng b\u1ec7nh nh\u00e2n c\u00f3 nh\u1ecbp tim ch\u1eadm c\u00f3 tri\u1ec7u ch\u1ee9ng c\u00f3 th\u1ec3 li\u00ean quan \u0111\u1ebfn r\u1ed1i lo\u1ea1n ch\u1ee9c n\u0103ng n\u00fat xoang, \u0111\u1eb7c bi\u1ec7t n\u1ebfu t\u1ea7n s\u1ed1 gi\u1ea3m h\u01a1n n\u1eefa, tr\u1eeb khi c\u00f3 m\u00e1y t\u1ea1o nh\u1ecbp tim nh\u00e2n t\u1ea1o.<\/p>\n<p>Thu\u1ed1c ch\u1eb9n beta c\u0169ng l\u00e0m gi\u1ea3m d\u1eabn truy\u1ec1n qua n\u00fat nh\u0129 th\u1ea5t (AV), c\u00f3 kh\u1ea3 n\u0103ng g\u00e2y ra block tim. Do \u0111\u00f3, vi\u1ec7c s\u1eed d\u1ee5ng thu\u1ed1c ch\u1eb9n beta c\u00f3 th\u1ec3 d\u1eabn \u0111\u1ebfn nh\u1ecbp tim ch\u1eadm nghi\u00eam tr\u1ecdng \u1edf nh\u1eefng b\u1ec7nh nh\u00e2n c\u00f3 khi\u1ebfm khuy\u1ebft d\u1eabn truy\u1ec1n AV ho\u00e0n to\u00e0n ho\u1eb7c m\u1ed9t ph\u1ea7n ti\u1ec1m \u1ea9n (ngh\u0129a l\u00e0 block AV \u0111\u1ed9 hai ho\u1eb7c \u0111\u1ed9 ba), \u0111\u1eb7c bi\u1ec7t n\u1ebfu b\u1ec7nh nh\u00e2n c\u0169ng \u0111ang d\u00f9ng m\u1ed9t t\u00e1c nh\u00e2n kh\u00e1c l\u00e0m suy y\u1ebfu d\u1eabn truy\u1ec1n n\u00fat AV nh\u01b0 nh\u01b0 digoxin ho\u1eb7c thu\u1ed1c ch\u1eb9n k\u00eanh canxi. C\u00e1c h\u1ee3p ch\u1ea5t c\u00f3 ISA c\u00f3 th\u1ec3 \u00edt g\u00e2y suy gi\u1ea3m d\u1eabn truy\u1ec1n AV h\u01a1n<\/p>\n<h3><strong>1.3. T\u00e1c d\u1ee5ng ph\u1ee5 khi ng\u1eebng thu\u1ed1c ch\u1eb9n beta\u00a0<\/strong><\/h3>\n<p>Ng\u1eebng thu\u1ed1c ch\u1eb9n beta c\u1ea5p t\u00ednh c\u00f3 th\u1ec3 d\u1eabn \u0111\u1ebfn tri\u1ec7u ch\u1ee9ng nghi\u00eam tr\u1ecdng v\u00e0 th\u1eadm ch\u00ed t\u1eed vong. M\u1ed1i quan t\u00e2m quan tr\u1ecdng nh\u1ea5t v\u1edbi vi\u1ec7c ng\u1eebng thu\u1ed1c ch\u1eb9n beta l\u00e0 s\u1ef1 tr\u1ea7m tr\u1ecdng th\u00eam c\u1ee7a c\u00e1c tri\u1ec7u ch\u1ee9ng thi\u1ebfu m\u00e1u c\u1ee5c b\u1ed9, bao g\u1ed3m c\u1ea3 s\u1ef1 k\u1ebft th\u00fac c\u1ee7a nh\u1ed3i m\u00e1u c\u01a1 tim c\u1ea5p t\u00ednh, \u1edf nh\u1eefng b\u1ec7nh nh\u00e2n \u0111\u00e3 bi\u1ebft c\u00f3 b\u1ec7nh \u0111\u1ed9ng m\u1ea1ch v\u00e0nh<\/p>\n<h3>2. M\u1ee5c ti\u00eau \u0111i\u1ec1u tr\u1ecb<\/h3>\n<p>M\u1ee5c ti\u00eau \u0111i\u1ec1u tr\u1ecb ch\u00ednh c\u1ee7a thu\u1ed1c ch\u1eb9n beta trong \u0111au th\u1eaft ng\u1ef1c \u1ed5n \u0111\u1ecbnh m\u1ea1n t\u00ednh l\u00e0 gi\u1ea3m t\u1ea7n su\u1ea5t v\u00e0 m\u1ee9c \u0111\u1ed9 nghi\u00eam tr\u1ecdng c\u1ee7a c\u01a1n \u0111au th\u1eaft ng\u1ef1c v\u00e0 c\u1ea3i thi\u1ec7n kh\u1ea3 n\u0103ng g\u1eafng s\u1ee9c m\u00e0 kh\u00f4ng c\u00f3 t\u00e1c d\u1ee5ng ph\u1ee5 \u0111\u00e1ng k\u1ec3. Nh\u01b0 \u0111\u00e3 l\u01b0u \u00fd \u1edf tr\u00ean, hi\u1ec7u qu\u1ea3 c\u1ee7a thu\u1ed1c ch\u1eb9n beta trong vi\u1ec7c gi\u1ea3m \u0111au th\u1eaft ng\u1ef1c ph\u1ee5 thu\u1ed9c v\u00e0o li\u1ec1u l\u01b0\u1ee3ng. Do \u0111\u00f3, \u0111i\u1ec1u quan tr\u1ecdng l\u00e0 ph\u1ea3i ch\u1eafc ch\u1eafn r\u1eb1ng \u0111\u00e3 \u0111\u1ea1t \u0111\u01b0\u1ee3c s\u1ef1 phong t\u1ecfa beta \u0111\u1ea7y \u0111\u1ee7.<\/p>\n<p>Li\u00ean quan \u0111\u1ebfn vi\u1ec7c b\u1eaft \u0111\u1ea7u \u0111i\u1ec1u tr\u1ecb b\u1eb1ng thu\u1ed1c ch\u1eb9n beta, n\u00ean b\u1eaft \u0111\u1ea7u v\u1edbi li\u1ec1u khuy\u1ebfn c\u00e1o th\u1ea5p nh\u1ea5t cho thu\u1ed1c \u0111\u00e3 ch\u1ecdn. V\u00ec m\u1ee5c ti\u00eau t\u1ed5ng th\u1ec3 l\u00e0 gi\u1ea3m t\u1ea7n su\u1ea5t v\u00e0 m\u1ee9c \u0111\u1ed9 nghi\u00eam tr\u1ecdng c\u1ee7a c\u01a1n \u0111au th\u1eaft ng\u1ef1c, n\u00ean c\u00f3 th\u1ec3 kh\u00f4ng c\u1ea7n thi\u1ebft ph\u1ea3i \u0111i\u1ec1u ch\u1ec9nh li\u1ec1u cao \u1edf m\u1ed9t s\u1ed1 b\u1ec7nh nh\u00e2n. Tr\u00e1nh d\u00f9ng li\u1ec1u cao c\u00f3 th\u1ec3 l\u00e0m gi\u1ea3m kh\u1ea3 n\u0103ng t\u00e1c d\u1ee5ng ph\u1ee5.<\/p>\n<p>C\u00e1c m\u1ee5c ti\u00eau h\u1ee3p l\u00fd khi ch\u1ec9nh li\u1ec1u bao g\u1ed3m:<\/p>\n<ul>\n<li>Nh\u1ecbp tim l\u00fac ngh\u1ec9 ng\u01a1i trong kho\u1ea3ng 60 \u0111\u1ebf n 70 nh\u1ecbp\/ph\u00fat. M\u1eb7c d\u00f9 ch\u00fang ta kh\u00f4ng c\u00f3 m\u1ee5c ti\u00eau nh\u1ecbp tim c\u1ee5 th\u1ec3 cho vi\u1ec7c t\u1eadp th\u1ec3 d\u1ee5c, nh\u01b0ng vi\u1ec7c gi\u1ea3m \u0111au th\u1eaft ng\u1ef1c m\u00e0 kh\u00f4ng g\u00e2y kh\u00f3 th\u1edf v\u00e0 m\u1ec7t m\u1ecfi do b\u1ecb \u1ee9c ch\u1ebf beta qu\u00e1 m\u1ee9c l\u00e0 m\u1ed9t c\u00e1ch ti\u1ebfp c\u1eadn h\u1ee3p l\u00fd.<\/li>\n<li>B\u1ec7nh nh\u00e2n b\u1ecb nh\u1ecbp tim ch\u1eadm tr\u01b0\u1edbc khi \u0111i\u1ec1u tr\u1ecb c\u00f3 th\u1ec3 \u0111\u01b0\u1ee3c \u0111i\u1ec1u tr\u1ecb b\u1eb1ng nitrat, ho\u1eb7c, n\u1ebfu c\u1ea7n d\u00f9ng thu\u1ed1c ch\u1eb9n beta, m\u1ed9t lo\u1ea1i thu\u1ed1c c\u00f3 ho\u1ea1t t\u00ednh giao c\u1ea3m n\u1ed9i t\u1ea1i. C\u0169ng h\u1ee3p l\u00fd khi \u0111i\u1ec1u tr\u1ecb b\u1eb1ng thu\u1ed1c ch\u1eb9n beta ti\u00eau chu\u1ea9n v\u1edbi li\u1ec1u l\u01b0\u1ee3ng th\u1ea5p v\u00e0 chu\u1ea9n \u0111\u1ed9 theo nh\u1ecbp tim ngh\u1ec9 ng\u01a1i v\u00e0 t\u1eadp th\u1ec3 d\u1ee5c.<\/li>\n<li>C\u00e2n nh\u1eafc t\u01b0\u01a1ng t\u1ef1 \u00e1p d\u1ee5ng cho b\u1ec7nh nh\u00e2n ch\u1eadm d\u1eabn truy\u1ec1n nh\u0129 th\u1ea5t.<\/li>\n<li>L\u00e0m gi\u1ea3m nh\u1ecbp tim v\u00e0 huy\u1ebft \u00e1p t\u00e2m thu trong khi t\u1eadp th\u1ec3 d\u1ee5c, b\u1ec7nh nh\u00e2n c\u00f3 th\u1ec3 \u0111o \u0111\u01b0\u1ee3c ho\u1eb7c trong qu\u00e1 tr\u00ecnh ki\u1ec3m tra t\u1eadp th\u1ec3 d\u1ee5c, n\u1ebfu \u0111\u01b0\u1ee3c.<\/li>\n<li>Kh\u00f4ng c\u00f3 t\u00e1c d\u1ee5ng ph\u1ee5 \u0111\u00e1ng k\u1ec3.<\/li>\n<\/ul>\n","protected":false},"excerpt":{"rendered":"<p>H\u1ea7u h\u1ebft c\u00e1c t\u00e1c d\u1ee5ng ph\u1ee5 ch\u00ednh c\u1ee7a thu\u1ed1c ch\u1eb9n beta l\u00e0 do phong t\u1ecfa th\u1ee5 th\u1ec3 beta-adrenoreceptor. Do \u0111\u00f3, nhi\u1ec1u d\u1ea5u hi\u1ec7u v\u00e0 tri\u1ec7u ch\u1ee9ng c\u00f3 th\u1ec3 \u0111\u01b0\u1ee3c t\u1ea1o ra do c\u00e1c th\u1ee5 th\u1ec3 beta \u1ea3nh h\u01b0\u1edfng \u0111\u1ebfn nhi\u1ec1u ch\u1ee9c n\u0103ng sinh l\u00fd v\u00e0 trao \u0111\u1ed5i ch\u1ea5t. C\u00e1c ph\u1ea3n \u1ee9ng kh\u00e1c d\u01b0\u1eddng nh\u01b0 kh\u00f4ng [&hellip;]<\/p>\n","protected":false},"author":60,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[7,33],"tags":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v20.4 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>T\u00e1c d\u1ee5ng ph\u1ee5 ch\u00ednh c\u1ee7a thu\u1ed1c ch\u1eb9n beta - Vinmec<\/title>\n<meta name=\"description\" content=\"H\u1ea7u h\u1ebft c\u00e1c t\u00e1c d\u1ee5ng ph\u1ee5 ch\u00ednh c\u1ee7a thu\u1ed1c ch\u1eb9n beta l\u00e0 do phong t\u1ecfa th\u1ee5 th\u1ec3 beta-adrenoreceptor \u1ea3nh h\u01b0\u1edfng \u0111\u1ebfn nhi\u1ec1u ch\u1ee9c n\u0103ng sinh l\u00fd\" \/>\n<meta name=\"robots\" content=\"noindex, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"T\u00e1c d\u1ee5ng ph\u1ee5 ch\u00ednh c\u1ee7a thu\u1ed1c ch\u1eb9n beta - 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