{"id":20997,"date":"2023-04-14T21:07:52","date_gmt":"2023-04-14T14:07:52","guid":{"rendered":"http:\/\/noithathoaphat.in\/ctv\/?p=20997"},"modified":"2023-04-17T16:11:37","modified_gmt":"2023-04-17T09:11:37","slug":"chen-kenh-calci-va-co-che-tac-dung","status":"publish","type":"post","link":"http:\/\/noithathoaphat.in\/ctv\/index.php\/2023\/04\/14\/chen-kenh-calci-va-co-che-tac-dung\/","title":{"rendered":"Nh\u00f3m thu\u1ed1c ch\u1eb9n k\u00eanh calci v\u00e0 c\u01a1 ch\u1ebf t\u00e1c d\u1ee5ng"},"content":{"rendered":"

Nh\u00f3m thu\u1ed1c ch\u1eb9n k\u00eanh calci (CCB) l\u00e0 m\u1ed9t nh\u00f3m thu\u1ed1c \u1ee9c ch\u1ebf ch\u1ecdn l\u1ecdc k\u00eanh calci n\u1eb1m tr\u00ean m\u00e0ng t\u1ebf b\u00e0o c\u01a1 tr\u01a1n m\u1ea1ch m\u00e1u v\u00e0 c\u01a1 tim, do \u0111\u00f3 l\u00e0m gi\u00e1n \u0111o\u1ea1n s\u1ef1 di chuy\u1ec3n c\u1ee7a d\u00f2ng calci \u0111i v\u00e0o trong t\u1ebf b\u00e0o. Thu\u1ed1c ch\u1eb9n k\u00eanh calci l\u00e0 m\u1ed9t nh\u00f3m thu\u1ed1c kh\u00f4ng \u0111\u1ed3ng nh\u1ea5t v\u1ec1 m\u1eb7t h\u00f3a h\u1ecdc, c\u00f3 th\u1ec3 \u0111\u01b0\u1ee3c ph\u00e2n lo\u1ea1i th\u00e0nh ph\u00e2n nh\u00f3m dihydropyridine (DHP) v\u00e0 kh\u00f4ng ph\u1ea3i dihydropyridine (non-DHP).<\/strong><\/p>\n

1.G<\/strong>i\u1edbi thi\u1ec7u chung <\/strong><\/h2>\n

Ion calci l\u00e0 nguy\u00ean t\u1ed1 thi\u1ebft y\u1ebfu c\u1ee7a s\u1ef1 s\u1ed1ng. Trong c\u01a1 th\u1ec3, 98% calci n\u1eb1m \u1edf x\u01b0\u01a1ng v\u00e0 r\u0103ng, 2% c\u00f2n l\u1ea1i l\u00e0 c\u00e1c ion calci trong m\u00e1u \u0111\u1ec3 th\u1ef1c hi\u1ec7n c\u00e1c ch\u1ee9c n\u0103ng th\u1ea7n kinh, c\u01a1, \u0111\u00f4ng m\u00e1u\u2026 C\u00e1c ion calci \u0111\u00f3ng vai tr\u00f2 quan tr\u1ecdng trong ho\u1ea1t \u0111\u1ed9ng co c\u1ee7a m\u1ecdi lo\u1ea1i c\u01a1 trong \u0111\u00f3 c\u00f3 c\u01a1 tim, c\u01a1 tr\u01a1n th\u00e0nh m\u1ea1ch m\u00e1u.<\/p>\n

Thu\u1ed1c ch\u1eb9n k\u00eanh calci (CCB) l\u00e0 m\u1ed9t nh\u00f3m thu\u1ed1c \u1ee9c ch\u1ebf ch\u1ecdn l\u1ecdc k\u00eanh calci n\u1eb1m tr\u00ean m\u00e0ng t\u1ebf b\u00e0o c\u01a1 tr\u01a1n m\u1ea1ch m\u00e1u v\u00e0 c\u01a1 tim, do \u0111\u00f3 l\u00e0m gi\u00e1n \u0111o\u1ea1n s\u1ef1 di chuy\u1ec3n c\u1ee7a d\u00f2ng calci \u0111i v\u00e0o trong t\u1ebf b\u00e0o. Thu\u1ed1c ch\u1eb9n k\u00eanh calci l\u00e0 m\u1ed9t nh\u00f3m thu\u1ed1c kh\u00f4ng \u0111\u1ed3ng nh\u1ea5t v\u1ec1 m\u1eb7t h\u00f3a h\u1ecdc, c\u00f3 th\u1ec3 \u0111\u01b0\u1ee3c ph\u00e2n lo\u1ea1i th\u00e0nh ph\u00e2n nh\u00f3m dihydropyridine (DHP) v\u00e0 kh\u00f4ng ph\u1ea3i dihydropyridine (non-DHP).<\/p>\n

S\u1ef1 kh\u00e1c bi\u1ec7t gi\u1eefa c\u00e1c DHP v\u00e0 non-DHP l\u00e0 \u1edf c\u00e1c v\u1ecb tr\u00ed g\u1eafn k\u1ebft kh\u00e1c nhau tr\u00ean k\u00eanh calci v\u00e0 m\u1ee9c \u0111\u1ed9 ch\u1ecdn l\u1ecdc kh\u00e1c nhau tr\u00ean m\u1ea1ch m\u00e1u l\u1edbn d\u1eabn \u0111\u1ebfn c\u00e1c t\u00e1c d\u1ee5ng d\u01b0\u1ee3c l\u00fd kh\u00e1c nhau.<\/p>\n

T\u00e1c d\u1ee5ng c\u1ee7a thu\u1ed1c ch\u1eb9n k\u00eanh calci tr\u00ean h\u1ec7 tim m\u1ea1ch ch\u1ee7 y\u1ebfu th\u00f4ng qua kh\u1ea3 n\u0103ng l\u00e0m gi\u00e3n m\u1ea1ch v\u00e0 gi\u1ea3m s\u1ee9c c\u1ea3n m\u1ea1ch ngo\u1ea1i bi\u00ean, do \u0111\u00f3 l\u00e0m h\u1ea1 huy\u1ebft \u00e1p.<\/p>\n

2. P<\/strong>h\u00e2n lo\u1ea1i thu\u1ed1c ch\u1eb9n k\u00eanh calci <\/strong><\/h2>\n

2.1. Ph\u00e2n lo\u1ea1i theo c\u1ea5u tr\u00fac ho\u00e1 h\u1ecdc<\/strong><\/h3>\n
    \n
  • DHP c\u00f3 ho\u1ea1t ch\u1ea5t Th\u1ebf h\u1ec7 1: Nifedipine v\u00e0 \u00a0Th\u1ebf h\u1ec7 2: Amlodipine, felodipine, isradipine, lacidipine, lercanidipine, nicardipine, nimodipine, nitrendipine<\/li>\n
  • Non-DHP \u00a0c\u00f3 ho\u1ea1t ch\u1ea5t l\u00e0: Verapamil v\u00e0 Diltiazem<\/li>\n<\/ul>\n

    3.C<\/strong>\u01a1 ch\u1ebf t\u00e1c d\u1ee5ng<\/strong><\/h2>\n

    3.1. T\u1ed5ng quan v\u1ec1 ion calci v\u00e0 k\u00eanh calci trong c\u01a1 th\u1ec3<\/strong>:<\/strong><\/h3>\n

    N\u1ed3ng \u0111\u1ed9 ion calci t\u1ef1 do trong b\u00e0o t\u01b0\u01a1ng \u0111\u00f3ng vai tr\u00f2 quan tr\u1ecdng \u0111i\u1ec1u ho\u00e0 ho\u1ea1t \u0111\u1ed9ng c\u1ee7a t\u1ebf b\u00e0o, trong \u0111\u00f3 c\u00f3 ho\u1ea1t \u0111\u1ed9ng co c\u01a1 c\u1ee7a c\u00e1c t\u1ebf b\u00e0o c\u01a1 tr\u01a1n th\u00e0nh m\u1ea1ch m\u00e1u, c\u01a1 tim v\u00e0 c\u1ea3 ho\u1ea1t \u0111\u1ed9ng t\u1ea1o nh\u1ecbp hay d\u1eabn truy\u1ec1n c\u1ee7a n\u00fat xoang v\u00e0 n\u00fat nh\u0129 th\u1ea5t. Ion calci \u0111i v\u00e0o trong t\u1ebf b\u00e0o qua b\u1ed1n con \u0111\u01b0\u1eddng ch\u00ednh:<\/p>\n

      \n
    • C\u00e1c k\u00eanh calci ph\u1ee5 thu\u1ed9c \u0111i\u1ec7n th\u1ebf.<\/li>\n
    • C\u00e1c k\u00eanh calci g\u1eafn ch\u1ea5t k\u1ebft n\u1ed1i.<\/li>\n
    • C\u00e1c k\u00eanh calci v\u1eadn h\u00e0nh b\u1edfi kho d\u1ef1 tr\u1eef (SOCs).<\/li>\n
    • Trao \u0111\u1ed5i Na+\u2013 ion Ca2+<\/li>\n<\/ul>\n

      K\u00eanh calci ph\u1ee5 thu\u1ed9c \u0111i\u1ec7n th\u1ebf ch\u1ee9a c\u00e1c mi\u1ec1n c\u1ee7a c\u00e1c chu\u1ed7i t\u01b0\u01a1ng \u0111\u1ed3ng \u0111\u01b0\u1ee3c s\u1eafp x\u1ebfp song song c\u00f9ng v\u1edbi m\u1ed9t ti\u1ec3u \u0111\u01a1n v\u1ecb l\u1edbn \u2013 ti\u1ec3u \u0111\u01a1n v\u1ecb \u03b11 c\u00f3 vai tr\u00f2 ch\u00ednh h\u00ecnh th\u00e0nh k\u00eanh calci v\u00e0 m\u1ed9t s\u1ed1 c\u00e1c ti\u1ec3u \u0111\u01a1n v\u1ecb kh\u00e1c c\u00f3 li\u00ean quan (\u03b12, \u03b2, \u03b3 v\u00e0 \u03b4). K\u00eanh calci ph\u1ee5 thu\u1ed9c \u0111i\u1ec7n th\u1ebf \u0111\u01b0\u1ee3c chia th\u00e0nh \u00edt nh\u1ea5t s\u00e1u lo\u1ea1i d\u1ef1a tr\u00ean th\u1eddi gian t\u00e1c d\u1ee5ng v\u00e0 \u0111\u1ed9 nh\u1ea1y v\u1edbi \u0111i\u1ec7n th\u1ebf, trong \u0111\u00f3 hai lo\u1ea1i th\u01b0\u1eddng g\u1eb7p l\u00e0 k\u00eanh lo\u1ea1i L (long-acting) v\u00e0 lo\u1ea1i T (transient) c\u00f3 \u1edf c\u00e1c t\u1ebf b\u00e0o c\u01a1 tr\u01a1n m\u1ea1ch m\u00e1u, c\u01a1 tim v\u00e0 n\u00fat d\u1eabn truy\u1ec1n ,ngo\u00e0i ra lo\u1ea1i N t\u00ecm th\u1ea5y nhi\u1ec1u \u1edf t\u1ebf b\u00e0o th\u1ea7n kinh.<\/p>\n

      \u0110\u1eb7c \u0111i\u1ec3m c\u1ee7a c\u00e1c lo\u1ea1i k\u00eanh n\u00e0y nh\u01b0 sau:<\/p>\n

        \n
      • \u00a0Lo\u1ea1i L (long \u2013 acting: t\u00e1c d\u1ee5ng k\u00e9o d\u00e0i):<\/li>\n<\/ul>\n

        C\u00f3 nhi\u1ec1u \u1edf t\u1ebf b\u00e0o c\u01a1 tr\u01a1n v\u00e0 c\u01a1 tim nh\u01b0ng c\u0169ng t\u00ecm th\u1ea5y \u1edf c\u00e1c t\u1ebf b\u00e0o n\u1ed9i ti\u1ebft v\u00e0 t\u1ebf b\u00e0o th\u1ea7n kinh. \u0110\u01b0\u1ee3c ho\u1ea1t ho\u00e1 \u1edf c\u01b0\u1eddng \u0111\u1ed9 kh\u1eed c\u1ef1c cao (ng\u01b0\u1ee1ng ho\u1ea1t \u0111\u1ed9ng cao). T\u00e1c d\u1ee5ng k\u00e9o d\u00e0i (t\u1ed1c \u0111\u1ed9 ho\u1ea1t ho\u00e1 ch\u1eadm).<\/p>\n

          \n
        • Lo\u1ea1i T (transient: t\u1ea1m th\u1eddi):<\/li>\n<\/ul>\n

          C\u00f3 nhi\u1ec1u \u1edf t\u1ebf b\u00e0o t\u1ea1o nh\u1ecbp c\u1ee7a tim, t\u00e2m nh\u0129, nh\u01b0ng c\u0169ng c\u00f3 \u1edf t\u1ebf b\u00e0o c\u01a1 tim, c\u01a1 tr\u01a1n, t\u1ebf b\u00e0o th\u1ea7n kinh. \u0110\u01b0\u1ee3c ho\u1ea1t ho\u00e1 \u1edf c\u01b0\u1eddng \u0111\u1ed9 kh\u1eed c\u1ef1c y\u1ebfu. T\u1ea1m th\u1eddi (b\u1ea5t ho\u1ea1t nhanh).<\/p>\n

            \n
          • Lo\u1ea1i N:<\/li>\n<\/ul>\n

            T\u00ecm th\u1ea5y nhi\u1ec1u \u1edf t\u1ebf b\u00e0o th\u1ea7n kinh: kh\u1edfi ph\u00e1t d\u1eabn truy\u1ec1n th\u1ea7n kinh. C\u1ea7n kh\u1eed c\u1ef1c m\u1ea1nh \u0111\u1ec3 ho\u1ea1t ho\u00e1.<\/p>\n

            3.2. C\u01a1 ch\u1ebf t\u00e1c d\u1ee5ng c\u1ee7a c\u00e1c thu\u1ed1c ch\u1eb9n k\u00eanh calci<\/strong><\/h3>\n

            \u00a0<\/strong>3.2.1<\/strong>. V\u1ecb tr\u00ed t\u00e1c \u0111\u1ed9ng c\u1ee7a c\u00e1c thu\u1ed1c ch\u1eb9n k\u00eanh calci <\/strong><\/h4>\n

            Thu\u1ed1c ch\u1eb9n k\u00eanh calci ho\u1ea1t \u0111\u1ed9ng t\u1ea1i m\u00e0ng t\u1ebf b\u00e0o \u0111\u1ec3 \u1ee9c ch\u1ebf s\u1ef1 v\u1eadn chuy\u1ec3n ion calci v\u00e0o n\u1ed9i b\u00e0o b\u1eb1ng c\u00e1ch ch\u1eb9n c\u00e1c k\u00eanh calci ph\u1ee5 thu\u1ed9c \u0111i\u1ec7n th\u1ebf. T\u1ea5t c\u1ea3 c\u00e1c thu\u1ed1c ch\u1eb9n k\u00eanh calci \u0111\u1ec1u g\u1eafn v\u00e0o ti\u1ec3u ph\u1ea7n \u03b11 c\u1ee7a k\u00eanh calci<\/p>\n

            T\u1ea1i ti\u1ec3u ph\u1ea7n \u03b11, c\u00e1c thu\u1ed1c ch\u1eb9n k\u00eanh calci c\u00f3 c\u00e1c v\u1ecb tr\u00ed g\u1eafn kh\u00e1c nhau:<\/p>\n

              \n
            • V\u1ecb tr\u00ed N: Nifedipine, c\u00e1c DHP kh\u00e1c.<\/li>\n
            • V\u1ecb tr\u00ed D: Diltiazem.<\/li>\n
            • V\u1ecb tr\u00ed V: Verapamil. Amlodipine c\u00f3 th\u1ec3 g\u1eafn th\u00eam \u1edf v\u1ecb tr\u00ed D v\u00e0 V<\/li>\n<\/ul>\n

              3.3.2<\/strong>. C\u01a1 ch\u1ebf t\u00e1c d\u1ee5ng <\/strong><\/h4>\n
              3.3.2.1 <\/strong>Tr\u00ean t\u1ebf b\u00e0o c\u01a1 tim: <\/strong><\/h5>\n

              Qu\u00e1 tr\u00ecnh kh\u1eed c\u1ef1c m\u00e0ng t\u1ebf b\u00e0o c\u01a1 tim b\u1eaft \u0111\u1ea7u b\u1eb1ng m\u1ed9t d\u00f2ng ion natri nhanh v\u00e0 ng\u1eafn th\u00f4ng qua k\u00eanh natri \u0111\u1ed3ng th\u1eddi m\u1edf k\u00eanh calci lo\u1ea1i L, th\u1eddi gian m\u1edf k\u00eanh calci k\u00e9o d\u00e0i v\u00e0i ph\u1ea7n m\u01b0\u1eddi gi\u00e2y, l\u00e0m cho l\u01b0\u1ee3ng l\u1edbn ion calci v\u00e0o trong t\u1ebf b\u00e0o duy tr\u00ec tr\u1ea1ng th\u00e1i kh\u1eed c\u1ef1c l\u00e2u d\u00e0i, t\u1ea1o \u0111\u01b0\u1eddng cao nguy\u00ean c\u1ee7a \u0111i\u1ec7n th\u1ebf ho\u1ea1t \u0111\u1ed9ng. Trong t\u1ebf b\u00e0o c\u01a1 tim, ion calci s\u1ebd g\u1eafn v\u1edbi troponin C, l\u00e0m m\u1ea5t t\u00e1c d\u1ee5ng \u1ee9c ch\u1ebf c\u1ee7a ph\u1ee9c h\u1ee3p troponin tr\u00ean ch\u1ee9c n\u0103ng co b\u00f3p, do \u0111\u00f3 cho ph\u00e9p c\u00e1c s\u1ee3i actin c\u00f3 th\u1ec3 t\u01b0\u01a1ng t\u00e1c v\u1edbi s\u1ee3i myosin, g\u00e2y co b\u00f3p c\u01a1 tim. B\u1eb1ng c\u00e1ch \u1ee9c ch\u1ebf d\u00f2ng ion calci, thu\u1ed1c ch\u1eb9n k\u00eanh calci l\u00e0m gi\u1ea3m n\u1ed3ng \u0111\u1ed9 ion calci n\u1ed9i b\u00e0o trong th\u00ec t\u00e2m thu d\u1eabn \u0111\u1ebfn t\u00e1c d\u1ee5ng gi\u1ea3m co b\u00f3p c\u01a1 tim<\/p>\n

              3.3.2.2 <\/strong>Tr\u00ean t\u1ebf b\u00e0o c\u01a1 tr\u01a1n m\u1ea1ch m\u00e1u.<\/strong><\/h5>\n

              C\u00f3 \u00edt nh\u1ea5t hai c\u01a1 ch\u1ebf kh\u00e1c nhau g\u00e2y co th\u1eaft c\u01a1 tr\u01a1n m\u1ea1ch m\u00e1u.<\/p>\n

              Th\u1ee9 nh\u1ea5t, kh\u1eed c\u1ef1c m\u00e0ng t\u1ebf b\u00e0o m\u1edf k\u00eanh calci ph\u1ee5 thu\u1ed9c \u0111i\u1ec7n th\u1ebf l\u00e0m l\u01b0\u1ee3ng l\u1edbn ion calci v\u00e0o trong t\u1ebf b\u00e0o.<\/p>\n

              Th\u1ee9 hai, co th\u1eaft c\u01a1 tr\u01a1n ph\u1ee5 thu\u1ed9c ch\u1ea5t \u0111\u1ed3ng v\u1eadn kh\u00f4ng ph\u1ee5 thu\u1ed9c v\u00e0o kh\u1eed c\u1ef1c m\u00e0ng t\u1ebf b\u00e0o d\u1eabn \u0111\u1ebfn ho\u1ea1t h\u00f3a con \u0111\u01b0\u1eddng Protein G- Phospholipase C- Inosine Triphosphate (IP3), IP3 g\u1eafn v\u1edbi th\u1ee5 th\u1ec3 \u0111\u1eb7c hi\u1ec7u l\u00e0m m\u1edf c\u00e1c k\u00eanh calci (Phospholamban) \u1edf l\u01b0\u1edbi n\u1ed9i sinh ch\u1ea5t gi\u1ea3i ph\u00f3ng ion calci v\u00e0o b\u00e0o t\u01b0\u01a1ng. Ion calci trong b\u00e0o t\u01b0\u01a1ng s\u1ebd g\u1eafn v\u1edbi protein calmodulin, l\u00e0m thay \u0111\u1ed5i c\u1ea5u tr\u00fac calmodulin tr\u1edf n\u00ean ho\u1ea1t \u0111\u1ed9ng, ph\u1ee9c h\u1ee3p n\u00e0y s\u1ebd ho\u1ea1t h\u00f3a myosin light chain kinase, d\u1eabn \u0111\u1ebfn phosphoryl h\u00f3a chu\u1ed7i nh\u1eb9 myosin, t\u0103ng s\u1ef1 t\u01b0\u01a1ng t\u00e1c s\u1ee3i actin v\u00e0 myosin, g\u00e2y co th\u1eaft c\u01a1 tr\u01a1n. Sau khi t\u00e1c \u0111\u1ed9ng, n\u1ed3ng \u0111\u1ed9 ion calci n\u1ed9i b\u00e0o s\u1ebd gi\u1ea3m do ion calci \u0111\u01b0\u1ee3c b\u01a1m tr\u1edf l\u1ea1i l\u01b0\u1edbi n\u1ed9i sinh ch\u1ea5t ho\u1eb7c ra ngo\u1ea1i b\u00e0o nh\u1edd k\u00eanh natri-ion calci<\/p>\n

              3.3.2.3<\/strong> T\u00e1c d\u1ee5ng c\u1ee7a thu\u1ed1c ch\u1eb9n k\u00eanh calci tr\u00ean c\u00e1c c\u01a1 quan <\/strong><\/h5>\n
                \n
              • Tr\u00ean c\u01a1 tr\u01a1n: l\u00e0m gi\u00e3n c\u00e1c lo\u1ea1i c\u01a1 tr\u01a1n, \u0111\u1eb7c bi\u1ec7t c\u00e1c ti\u1ec3u \u0111\u1ed9ng m\u1ea1ch v\u00e0 \u0111\u1ed9ng m\u1ea1ch v\u00e0nh.<\/li>\n
              • Tr\u00ean c\u01a1 tim: l\u00e0m gi\u1ea3m co b\u00f3p c\u01a1 tim, tuy nhi\u00ean m\u1ee9c \u0111\u1ed9 t\u00e1c d\u1ee5ng c\u1ee7a c\u00e1c thu\u1ed1c kh\u00e1c nhau.<\/li>\n
              • Tr\u00ean c\u00e1c n\u00fat d\u1eabn truy\u1ec1n: l\u00e0m gi\u1ea3m nh\u1ecbp tim, gi\u1ea3m d\u1eabn truy\u1ec1n (non-DHP: verapamil, diltiazem).<\/li>\n
              • Tr\u00ean m\u1ea1ch m\u00e1u n\u00e3o: nimodipine c\u00f3 t\u00ednh \u01b0a m\u1ee1 n\u00ean th\u1ea5m nhanh v\u00e0o th\u1ea7n kinh trung \u01b0\u01a1ng, c\u00f3 \u00e1i l\u1ef1c cao v\u1edbi m\u1ea1ch m\u00e1u n\u00e3o, \u0111\u01b0\u1ee3c d\u00f9ng \u0111\u1ec3 ch\u1ed1ng co th\u1eaft m\u1ea1ch m\u00e1u n\u00e3o trong \u0111i\u1ec1u tr\u1ecb xu\u1ea5t huy\u1ebft d\u01b0\u1edbi nh\u1ec7n.<\/li>\n<\/ul>\n","protected":false},"excerpt":{"rendered":"

                Nh\u00f3m thu\u1ed1c ch\u1eb9n k\u00eanh calci (CCB) l\u00e0 m\u1ed9t nh\u00f3m thu\u1ed1c \u1ee9c ch\u1ebf ch\u1ecdn l\u1ecdc k\u00eanh calci n\u1eb1m tr\u00ean m\u00e0ng t\u1ebf b\u00e0o c\u01a1 tr\u01a1n m\u1ea1ch m\u00e1u v\u00e0 c\u01a1 tim, do \u0111\u00f3 l\u00e0m gi\u00e1n \u0111o\u1ea1n s\u1ef1 di chuy\u1ec3n c\u1ee7a d\u00f2ng calci \u0111i v\u00e0o trong t\u1ebf b\u00e0o. Thu\u1ed1c ch\u1eb9n k\u00eanh calci l\u00e0 m\u1ed9t nh\u00f3m thu\u1ed1c kh\u00f4ng \u0111\u1ed3ng nh\u1ea5t […]<\/p>\n","protected":false},"author":7,"featured_media":20981,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[12,33],"tags":[3],"yoast_head":"\nCh\u1eb9n k\u00eanh calci v\u00e0 c\u01a1 ch\u1ebf t\u00e1c d\u1ee5ng<\/title>\n<meta name=\"description\" content=\"Ch\u1eb9n k\u00eanh calci v\u00e0 c\u01a1 ch\u1ebf t\u00e1c d\u1ee5ng l\u00e0 v\u1ea5n \u0111\u1ec1 \u0111\u01b0\u1ee3c quan t\u00e2m khi t\u00ecm hi\u1ec3u v\u1ec1 thu\u1ed1c ch\u1eb9n k\u00eanh calci. Tham kh\u1ea3o b\u00e0i vi\u1ebft d\u01b0\u1edbi \u0111\u00e2y \u0111\u1ec3 n\u1eafm c\u01a1 ch\u1ebf\" \/>\n<meta name=\"robots\" content=\"noindex, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Ch\u1eb9n k\u00eanh calci v\u00e0 c\u01a1 ch\u1ebf t\u00e1c d\u1ee5ng\" \/>\n<meta property=\"og:description\" content=\"Ch\u1eb9n k\u00eanh calci v\u00e0 c\u01a1 ch\u1ebf t\u00e1c d\u1ee5ng l\u00e0 v\u1ea5n \u0111\u1ec1 \u0111\u01b0\u1ee3c quan t\u00e2m khi t\u00ecm hi\u1ec3u v\u1ec1 thu\u1ed1c ch\u1eb9n k\u00eanh calci. Tham kh\u1ea3o b\u00e0i vi\u1ebft d\u01b0\u1edbi \u0111\u00e2y \u0111\u1ec3 n\u1eafm c\u01a1 ch\u1ebf\" \/>\n<meta property=\"og:url\" content=\"http:\/\/noithathoaphat.in\/ctv\/index.php\/2023\/04\/14\/chen-kenh-calci-va-co-che-tac-dung\/\" \/>\n<meta property=\"og:site_name\" content=\"Vinmec\" \/>\n<meta property=\"article:published_time\" content=\"2023-04-14T14:07:52+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2023-04-17T09:11:37+00:00\" \/>\n<meta property=\"og:image\" content=\"http:\/\/noithathoaphat.in\/ctv\/wp-content\/uploads\/2023\/04\/tai-xuong-4.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"254\" \/>\n\t<meta property=\"og:image:height\" content=\"198\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"author\" content=\"L\u01b0\u01a1ng Vi\u1ebft T\u00e0i\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"L\u01b0\u01a1ng Vi\u1ebft T\u00e0i\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"6 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"http:\/\/noithathoaphat.in\/ctv\/index.php\/2023\/04\/14\/chen-kenh-calci-va-co-che-tac-dung\/\",\"url\":\"http:\/\/noithathoaphat.in\/ctv\/index.php\/2023\/04\/14\/chen-kenh-calci-va-co-che-tac-dung\/\",\"name\":\"Ch\u1eb9n k\u00eanh calci v\u00e0 c\u01a1 ch\u1ebf t\u00e1c d\u1ee5ng\",\"isPartOf\":{\"@id\":\"http:\/\/noithathoaphat.in\/ctv\/#website\"},\"datePublished\":\"2023-04-14T14:07:52+00:00\",\"dateModified\":\"2023-04-17T09:11:37+00:00\",\"author\":{\"@id\":\"http:\/\/noithathoaphat.in\/ctv\/#\/schema\/person\/dded5c0d4cb1bb77d05cf29ab5f85629\"},\"description\":\"Ch\u1eb9n k\u00eanh calci v\u00e0 c\u01a1 ch\u1ebf t\u00e1c d\u1ee5ng l\u00e0 v\u1ea5n \u0111\u1ec1 \u0111\u01b0\u1ee3c quan t\u00e2m khi t\u00ecm hi\u1ec3u v\u1ec1 thu\u1ed1c ch\u1eb9n k\u00eanh calci. Tham kh\u1ea3o b\u00e0i vi\u1ebft d\u01b0\u1edbi \u0111\u00e2y \u0111\u1ec3 n\u1eafm c\u01a1 ch\u1ebf\",\"breadcrumb\":{\"@id\":\"http:\/\/noithathoaphat.in\/ctv\/index.php\/2023\/04\/14\/chen-kenh-calci-va-co-che-tac-dung\/#breadcrumb\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"http:\/\/noithathoaphat.in\/ctv\/index.php\/2023\/04\/14\/chen-kenh-calci-va-co-che-tac-dung\/\"]}]},{\"@type\":\"BreadcrumbList\",\"@id\":\"http:\/\/noithathoaphat.in\/ctv\/index.php\/2023\/04\/14\/chen-kenh-calci-va-co-che-tac-dung\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"http:\/\/noithathoaphat.in\/ctv\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Nh\u00f3m thu\u1ed1c ch\u1eb9n k\u00eanh calci v\u00e0 c\u01a1 ch\u1ebf t\u00e1c d\u1ee5ng\"}]},{\"@type\":\"WebSite\",\"@id\":\"http:\/\/noithathoaphat.in\/ctv\/#website\",\"url\":\"http:\/\/noithathoaphat.in\/ctv\/\",\"name\":\"Vinmec\",\"description\":\"H\u1ec7 th\u1ed1ng Y t\u1ebf Vinmec\",\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"http:\/\/noithathoaphat.in\/ctv\/?s={search_term_string}\"},\"query-input\":\"required name=search_term_string\"}],\"inLanguage\":\"en-US\"},{\"@type\":\"Person\",\"@id\":\"http:\/\/noithathoaphat.in\/ctv\/#\/schema\/person\/dded5c0d4cb1bb77d05cf29ab5f85629\",\"name\":\"L\u01b0\u01a1ng Vi\u1ebft T\u00e0i\",\"image\":{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"http:\/\/noithathoaphat.in\/ctv\/#\/schema\/person\/image\/\",\"url\":\"http:\/\/2.gravatar.com\/avatar\/50f51f67852bc7e49c0b8b60a1fefe3e?s=96&d=mm&r=g\",\"contentUrl\":\"http:\/\/2.gravatar.com\/avatar\/50f51f67852bc7e49c0b8b60a1fefe3e?s=96&d=mm&r=g\",\"caption\":\"L\u01b0\u01a1ng Vi\u1ebft T\u00e0i\"},\"url\":\"http:\/\/noithathoaphat.in\/ctv\/index.php\/author\/viettai304-304gmail-com\/\"}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"Ch\u1eb9n k\u00eanh calci v\u00e0 c\u01a1 ch\u1ebf t\u00e1c d\u1ee5ng","description":"Ch\u1eb9n k\u00eanh calci v\u00e0 c\u01a1 ch\u1ebf t\u00e1c d\u1ee5ng l\u00e0 v\u1ea5n \u0111\u1ec1 \u0111\u01b0\u1ee3c quan t\u00e2m khi t\u00ecm hi\u1ec3u v\u1ec1 thu\u1ed1c ch\u1eb9n k\u00eanh calci. Tham kh\u1ea3o b\u00e0i vi\u1ebft d\u01b0\u1edbi \u0111\u00e2y \u0111\u1ec3 n\u1eafm c\u01a1 ch\u1ebf","robots":{"index":"noindex","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"og_locale":"en_US","og_type":"article","og_title":"Ch\u1eb9n k\u00eanh calci v\u00e0 c\u01a1 ch\u1ebf t\u00e1c d\u1ee5ng","og_description":"Ch\u1eb9n k\u00eanh calci v\u00e0 c\u01a1 ch\u1ebf t\u00e1c d\u1ee5ng l\u00e0 v\u1ea5n \u0111\u1ec1 \u0111\u01b0\u1ee3c quan t\u00e2m khi t\u00ecm hi\u1ec3u v\u1ec1 thu\u1ed1c ch\u1eb9n k\u00eanh calci. Tham kh\u1ea3o b\u00e0i vi\u1ebft d\u01b0\u1edbi \u0111\u00e2y \u0111\u1ec3 n\u1eafm c\u01a1 ch\u1ebf","og_url":"http:\/\/noithathoaphat.in\/ctv\/index.php\/2023\/04\/14\/chen-kenh-calci-va-co-che-tac-dung\/","og_site_name":"Vinmec","article_published_time":"2023-04-14T14:07:52+00:00","article_modified_time":"2023-04-17T09:11:37+00:00","og_image":[{"width":254,"height":198,"url":"http:\/\/noithathoaphat.in\/ctv\/wp-content\/uploads\/2023\/04\/tai-xuong-4.jpg","type":"image\/jpeg"}],"author":"L\u01b0\u01a1ng Vi\u1ebft T\u00e0i","twitter_card":"summary_large_image","twitter_misc":{"Written by":"L\u01b0\u01a1ng Vi\u1ebft T\u00e0i","Est. reading time":"6 minutes"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"WebPage","@id":"http:\/\/noithathoaphat.in\/ctv\/index.php\/2023\/04\/14\/chen-kenh-calci-va-co-che-tac-dung\/","url":"http:\/\/noithathoaphat.in\/ctv\/index.php\/2023\/04\/14\/chen-kenh-calci-va-co-che-tac-dung\/","name":"Ch\u1eb9n k\u00eanh calci v\u00e0 c\u01a1 ch\u1ebf t\u00e1c d\u1ee5ng","isPartOf":{"@id":"http:\/\/noithathoaphat.in\/ctv\/#website"},"datePublished":"2023-04-14T14:07:52+00:00","dateModified":"2023-04-17T09:11:37+00:00","author":{"@id":"http:\/\/noithathoaphat.in\/ctv\/#\/schema\/person\/dded5c0d4cb1bb77d05cf29ab5f85629"},"description":"Ch\u1eb9n k\u00eanh calci v\u00e0 c\u01a1 ch\u1ebf t\u00e1c d\u1ee5ng l\u00e0 v\u1ea5n \u0111\u1ec1 \u0111\u01b0\u1ee3c quan t\u00e2m khi t\u00ecm hi\u1ec3u v\u1ec1 thu\u1ed1c ch\u1eb9n k\u00eanh calci. Tham kh\u1ea3o b\u00e0i vi\u1ebft d\u01b0\u1edbi \u0111\u00e2y \u0111\u1ec3 n\u1eafm c\u01a1 ch\u1ebf","breadcrumb":{"@id":"http:\/\/noithathoaphat.in\/ctv\/index.php\/2023\/04\/14\/chen-kenh-calci-va-co-che-tac-dung\/#breadcrumb"},"inLanguage":"en-US","potentialAction":[{"@type":"ReadAction","target":["http:\/\/noithathoaphat.in\/ctv\/index.php\/2023\/04\/14\/chen-kenh-calci-va-co-che-tac-dung\/"]}]},{"@type":"BreadcrumbList","@id":"http:\/\/noithathoaphat.in\/ctv\/index.php\/2023\/04\/14\/chen-kenh-calci-va-co-che-tac-dung\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"http:\/\/noithathoaphat.in\/ctv\/"},{"@type":"ListItem","position":2,"name":"Nh\u00f3m thu\u1ed1c ch\u1eb9n k\u00eanh calci v\u00e0 c\u01a1 ch\u1ebf t\u00e1c d\u1ee5ng"}]},{"@type":"WebSite","@id":"http:\/\/noithathoaphat.in\/ctv\/#website","url":"http:\/\/noithathoaphat.in\/ctv\/","name":"Vinmec","description":"H\u1ec7 th\u1ed1ng Y t\u1ebf Vinmec","potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"http:\/\/noithathoaphat.in\/ctv\/?s={search_term_string}"},"query-input":"required name=search_term_string"}],"inLanguage":"en-US"},{"@type":"Person","@id":"http:\/\/noithathoaphat.in\/ctv\/#\/schema\/person\/dded5c0d4cb1bb77d05cf29ab5f85629","name":"L\u01b0\u01a1ng Vi\u1ebft T\u00e0i","image":{"@type":"ImageObject","inLanguage":"en-US","@id":"http:\/\/noithathoaphat.in\/ctv\/#\/schema\/person\/image\/","url":"http:\/\/2.gravatar.com\/avatar\/50f51f67852bc7e49c0b8b60a1fefe3e?s=96&d=mm&r=g","contentUrl":"http:\/\/2.gravatar.com\/avatar\/50f51f67852bc7e49c0b8b60a1fefe3e?s=96&d=mm&r=g","caption":"L\u01b0\u01a1ng Vi\u1ebft T\u00e0i"},"url":"http:\/\/noithathoaphat.in\/ctv\/index.php\/author\/viettai304-304gmail-com\/"}]}},"_links":{"self":[{"href":"http:\/\/noithathoaphat.in\/ctv\/index.php\/wp-json\/wp\/v2\/posts\/20997"}],"collection":[{"href":"http:\/\/noithathoaphat.in\/ctv\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"http:\/\/noithathoaphat.in\/ctv\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"http:\/\/noithathoaphat.in\/ctv\/index.php\/wp-json\/wp\/v2\/users\/7"}],"replies":[{"embeddable":true,"href":"http:\/\/noithathoaphat.in\/ctv\/index.php\/wp-json\/wp\/v2\/comments?post=20997"}],"version-history":[{"count":5,"href":"http:\/\/noithathoaphat.in\/ctv\/index.php\/wp-json\/wp\/v2\/posts\/20997\/revisions"}],"predecessor-version":[{"id":23291,"href":"http:\/\/noithathoaphat.in\/ctv\/index.php\/wp-json\/wp\/v2\/posts\/20997\/revisions\/23291"}],"wp:featuredmedia":[{"embeddable":true,"href":"http:\/\/noithathoaphat.in\/ctv\/index.php\/wp-json\/wp\/v2\/media\/20981"}],"wp:attachment":[{"href":"http:\/\/noithathoaphat.in\/ctv\/index.php\/wp-json\/wp\/v2\/media?parent=20997"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"http:\/\/noithathoaphat.in\/ctv\/index.php\/wp-json\/wp\/v2\/categories?post=20997"},{"taxonomy":"post_tag","embeddable":true,"href":"http:\/\/noithathoaphat.in\/ctv\/index.php\/wp-json\/wp\/v2\/tags?post=20997"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}