{"id":20515,"date":"2023-04-23T00:19:11","date_gmt":"2023-04-22T17:19:11","guid":{"rendered":"http:\/\/noithathoaphat.in\/ctv\/?p=20515"},"modified":"2023-04-23T00:43:24","modified_gmt":"2023-04-22T17:43:24","slug":"4-dau-hieu-moi-cua-benh-ung-thu","status":"publish","type":"post","link":"http:\/\/noithathoaphat.in\/ctv\/index.php\/2023\/04\/23\/4-dau-hieu-moi-cua-benh-ung-thu\/","title":{"rendered":"4 d\u1ea5u hi\u1ec7u \u0111\u1ec1 xu\u1ea5t th\u00eam v\u00e0o s\u01a1 \u0111\u1ed3 10 \u0111\u1eb7c t\u00ednh c\u01a1 b\u1ea3n c\u1ee7a ung th\u01b0"},"content":{"rendered":"

Gi\u00e1o s\u01b0 Hanahan \u0111\u00e3 \u0111\u01b0a ra m\u1ed9t s\u01a1 \u0111\u1ed3 v\u1ec1 10 \u0111\u1eb7c t\u00ednh c\u1ee7a ung th\u01b0 \u0111\u1ec3 gi\u00fap \u0111\u1ecbnh ngh\u0129a v\u00e0 hi\u1ec3u r\u00f5 h\u01a1n v\u1ec1 b\u1ec7nh l\u00fd n\u00e0y. G\u1ea7n \u0111\u00e2y, c\u00e1c nh\u00e0 khoa h\u1ecdc \u0111\u00e3 \u0111\u1ec1 xu\u1ea5t th\u00eam v\u00e0o s\u01a1 \u0111\u1ed3 n\u00e0y 4 d\u1ea5u hi\u1ec7u m\u1edbi \u0111\u1ec3 m\u00f4 t\u1ea3 ch\u00ednh x\u00e1c h\u01a1n v\u1ec1 t\u00ednh ch\u1ea5t c\u1ee7a ung th\u01b0.<\/p>\n

1. \u0110\u1ea1i c\u01b0\u01a1ng v\u1ec1 10 \u0111\u1eb7c t\u00ednh c\u01a1 b\u1ea3n c\u1ee7a ung th\u01b0<\/h2>\n

\u0110\u1ea7u n\u0103m 2000, Gi\u00e1o s\u01b0 Hanahan v\u00e0 Weinberg \u0111\u1ec1 xu\u1ea5t r\u1eb1ng khi c\u00e1c t\u1ebf b\u00e0o ti\u1ebfn t\u1edbi tr\u1ea1ng th\u00e1i ung th\u01b0, ch\u00fang s\u1ebd c\u00f3 \u0111\u01b0\u1ee3c nh\u1eefng kh\u1ea3 n\u0103ng \u0111\u1eb7c bi\u1ec7t. \u0110\u00e2y \u0111\u01b0\u1ee3c g\u1ecdi l\u00e0 d\u1ea5u hi\u1ec7u \u0111\u1eb7c tr\u01b0ng c\u1ee7a b\u1ec7nh ung th\u01b0 v\u00e0 t\u1ea1o th\u00e0nh m\u1ed9t khu\u00f4n kh\u1ed5 h\u1eefu \u00edch \u0111\u1ec3 gi\u00fap hi\u1ec3u c\u01a1 ch\u1ebf b\u1ec7nh sinh c\u1ee7a kh\u1ed1i u. H\u1ecd \u0111\u00e3 nh\u1ea5t tr\u00ed th\u00f4ng qua 10 \u0111\u1eb7c t\u00ednh c\u01a1 b\u1ea3n<\/a> c\u1ee7a m\u1ed9t kh\u1ed1i u nh\u01b0 sau:<\/p>\n

\"\"
10 \u0111\u1eb7c t\u00ednh c\u01a1 b\u1ea3n c\u1ee7a t\u1ebf b\u00e0o ung th\u01b0<\/figcaption><\/figure>\n
    \n
  • T\u00edn hi\u1ec7u ph\u00e2n chia k\u00e9o d\u00e0i (sustaining proliferative signaling)<\/li>\n
  • T\u00e1i l\u1eadp c\u01a1 ch\u1ebf trao \u0111\u1ed5i ch\u1ea5t (deregulating cellular metabolism)<\/li>\n
  • Ch\u1ed1ng l\u1ea1i s\u1ef1 ch\u1ebft t\u1ebf b\u00e0o (resisting cell death)<\/li>\n
  • Gene m\u1ea5t \u1ed5n \u0111\u1ecbnh v\u00e0 g\u00e2y bi\u1ebfn \u0111\u1ed5i gene (genome instability and mutation)<\/li>\n
  • H\u00ecnh th\u00e0nh h\u1ec7 th\u1ed1ng m\u1ea1ch m\u00e1u m\u1edbi (inducing or accessing vasculature)<\/li>\n
  • X\u00e2m l\u1ea5n m\u00f4 v\u00e0 di c\u0103n (activating invasion and metastasis)<\/li>\n
  • Qu\u00e1 tr\u00ecnh vi\u00eam k\u00e9o d\u00e0i th\u00fac \u0111\u1ea9y cho kh\u1ed1i u ph\u00e1t tri\u1ec3n (tumor-promoting inflammation)<\/li>\n<\/ul>\n
      \n
    • Kh\u1ea3 n\u0103ng sao ch\u00e9p li\u00ean t\u1ee5c (enabling replicative immortality)<\/li>\n
    • Tr\u00e1nh b\u1ecb ph\u00e1 h\u1ee7y b\u1edfi h\u1ec7 th\u1ed1ng mi\u1ec5n d\u1ecbch (avoiding immune destruction)<\/li>\n
    • Tr\u00e1nh \u0111\u01b0\u1ee3c nh\u1eefng ch\u1ea5t \u1ee9c ch\u1ebf ph\u00e1t tri\u1ec3n (evading growth suppressors)<\/li>\n<\/ul>\n

      2. 4 d\u1ea5u hi\u1ec7u m\u1edbi \u0111\u1ec1 xu\u1ea5t b\u1ed5 sung v\u00e0o s\u01a1 \u0111\u1ed3 10 \u0111\u1eb7c t\u00ednh c\u1ee7a t\u1ebf b\u00e0o ung th\u01b0<\/h2>\n

      Trong b\u00e0i \u0111\u00e1nh gi\u00e1 m\u1edbi nh\u1ea5t n\u0103m 2022, Hanahan \u0111\u1ec1 xu\u1ea5t b\u1ed1n d\u1ea5u hi\u1ec7u\u00a0 m\u1edbi: gi\u1ea3i ph\u00f3ng t\u00ednh d\u1ebbo ki\u1ec3u h\u00ecnh, t\u00e1i l\u1eadp tr\u00ecnh bi\u1ec3u sinh kh\u00f4ng \u0111\u1ed9t bi\u1ebfn, h\u1ec7 vi sinh v\u1eadt \u0111a h\u00ecnh v\u00e0 t\u1ebf b\u00e0o l\u00e3o h\u00f3a. \u00d4ng xem x\u00e9t c\u00e1c b\u1eb1ng ch\u1ee9ng hi\u1ec7n c\u00f3 v\u1ec1 c\u00e1c d\u1ea5u hi\u1ec7u m\u1edbi \u0111\u01b0\u1ee3c \u0111\u1ec1 xu\u1ea5t, cho th\u1ea5y ch\u00fang c\u00f3 th\u1ec3 \u0111\u01b0\u1ee3c t\u00edch h\u1ee3p v\u00e0o c\u00e1c d\u1ea5u hi\u1ec7u c\u1ed1t l\u00f5i c\u1ee7a b\u1ec7nh ung th\u01b0 trong t\u01b0\u01a1ng lai.<\/p>\n

      \"\"
      4 \u0111\u1eb7c t\u00ednh m\u1edbi \u0111\u01b0\u1ee3c \u0111\u1ec1 xu\u1ea5t b\u1ed5 sung b\u00ean c\u1ea1nh 10 \u0111\u1eb7c t\u00ednh c\u1ed1t l\u00f5i<\/figcaption><\/figure>\n
        \n
      • X\u00e1c l\u1eadp t\u00ednh d\u1ebbo ki\u1ec3u h\u00ecnh<\/li>\n<\/ul>\n

        S\u1ef1 m\u1ec1m d\u1ebbo c\u1ee7a ki\u1ec3u h\u00ecnh (th\u01b0\u1eddng bi\u1ebfn) l\u00e0 hi\u1ec7n t\u01b0\u1ee3ng m\u1ed9t ki\u1ec3u gen c\u00f3 th\u1ec3 thay \u0111\u1ed5i ki\u1ec3u h\u00ecnh tr\u01b0\u1edbc c\u00e1c \u0111i\u1ec1u ki\u1ec7n m\u00f4i tr\u01b0\u1eddng kh\u00e1c nhau. Tuy nhi\u00ean m\u1ee9c \u0111\u1ed9 m\u1ec1m d\u1ebbo l\u1ea1i ph\u1ee5 thu\u1ed9c v\u00e0o ki\u1ec3u gen. M\u1ed7i ki\u1ec3u gen ch\u1ec9 c\u00f3 th\u1ec3 \u0111i\u1ec1u ch\u1ec9nh ki\u1ec3u h\u00ecnh c\u1ee7a m\u00ecnh trong m\u1ed9t ph\u1ea1m vi nh\u1ea5t \u0111inh.<\/p>\n

        C\u00e1c t\u1ebf b\u00e0o ung th\u01b0 x\u00e1c l\u1eadp t\u00ednh d\u1ebbo ki\u1ec3u h\u00ecnh – m\u1ed9t kh\u1ea3 n\u0103ng b\u1ecb h\u1ea1n ch\u1ebf trong c\u00e1c t\u1ebf b\u00e0o b\u00ecnh th\u01b0\u1eddng – \u0111\u1ec3 k\u00edch ho\u1ea1t c\u00e1c phi\u00ean b\u1ea3n kh\u00e1c nhau c\u1ee7a qu\u00e1 tr\u00ecnh bi\u1ec7t h\u00f3a b\u1ecb gi\u00e1n \u0111o\u1ea1n, t\u1eeb \u0111\u00f3 c\u00f3 th\u1ec3 t\u1ea1o \u0111i\u1ec1u ki\u1ec7n thu\u1eadn l\u1ee3i cho s\u1ef1 kh\u1edfi ph\u00e1t v\u00e0 ti\u1ebfn tri\u1ec3n c\u1ee7a ung th\u01b0. Hanahan l\u1eadp lu\u1eadn r\u1eb1ng s\u1ef1 thay \u0111\u1ed5i linh ho\u1ea1t nh\u01b0 v\u1eady th\u1ec3 hi\u1ec7n kh\u1ea3 n\u0103ng \u0111\u1eb7c tr\u01b0ng ri\u00eang bi\u1ec7t, kh\u00e1c bi\u1ec7t v\u1ec1 quy \u0111\u1ecbnh v\u00e0 ki\u1ec3u h\u00ecnh t\u1ebf b\u00e0o so v\u1edbi c\u00e1c d\u1ea5u hi\u1ec7u c\u1ed1t l\u00f5i c\u1ee7a b\u1ec7nh ung th\u01b0 \u0111\u00e3 \u0111\u01b0\u1ee3c thi\u1ebft l\u1eadp tr\u01b0\u1edbc \u0111\u00f3.<\/p>\n

        Trong b\u00e0i \u0111\u00e1nh gi\u00e1 c\u1ee7a m\u00ecnh, \u00f4ng ph\u00e2n bi\u1ec7t ba lo\u1ea1i t\u00ednh d\u1ebbo ki\u1ec3u h\u00ecnh ch\u00ednh: s\u1ef1 bi\u1ec7t h\u00f3a c\u1ee7a c\u00e1c t\u1ebf b\u00e0o tr\u01b0\u1edfng th\u00e0nh tr\u1edf l\u1ea1i tr\u1ea1ng th\u00e1i ti\u1ec1n th\u00e2n, ch\u1eb7n s\u1ef1 bi\u1ec7t h\u00f3a \u0111\u1ec3 \u0111\u00f3ng b\u0103ng c\u00e1c t\u1ebf b\u00e0o ung th\u01b0 \u1edf tr\u1ea1ng th\u00e1i t\u1ebf b\u00e0o ti\u1ec1n th\u00e2n\/t\u1ebf b\u00e0o g\u1ed1c v\u00e0 s\u1ef1 chuy\u1ec3n h\u00f3a th\u00e0nh c\u00e1c d\u00f2ng t\u1ebf b\u00e0o thay th\u1ebf. T\u1ea5t c\u1ea3 c\u00e1c lo\u1ea1i d\u1ebbo n\u00e0y x\u1ea3y ra \u1edf nhi\u1ec1u lo\u1ea1i ung th\u01b0 trong qu\u00e1 tr\u00ecnh h\u00ecnh th\u00e0nh kh\u1ed1i u, ti\u1ebfn tri\u1ec3n v\u00e0 \u0111\u00e1p \u1ee9ng \u0111i\u1ec1u tr\u1ecb.<\/p>\n

        \"\"
        Ung th\u01b0 \u0111\u1ea1i tr\u1ef1c tr\u00e0ng<\/figcaption><\/figure>\n

        Ung th\u01b0 \u0111\u1ea1i tr\u1ef1c tr\u00e0ng l\u00e0 m\u1ed9t v\u00ed d\u1ee5 \u0111i\u1ec3n h\u00ecnh c\u1ee7a t\u00ednh d\u1ebbo bi\u1ec7t h\u00f3a, v\u1edbi hai y\u1ebfu t\u1ed1 phi\u00ean m\u00e3, HOXA5 v\u00e0 SMAD4, \u0111\u01b0\u1ee3c bi\u1ec3u hi\u1ec7n cao trong c\u00e1c t\u1ebf b\u00e0o bi\u1ec3u m\u00f4 bi\u1ec7t h\u00f3a v\u00e0 b\u1ecb m\u1ea5t trong ung th\u01b0 bi\u1ec3u m\u00f4 ru\u1ed9t k\u1ebft ti\u1ebfn tri\u1ec3n. C\u00e1c v\u00ed d\u1ee5 v\u1ec1 s\u1ef1 bi\u1ec7t h\u00f3a b\u1ecb ch\u1eb7n bao g\u1ed3m th\u1ee5 th\u1ec3 h\u1ea1t nh\u00e2n axit retinoic \u03b1 (RAR alpha) trong b\u1ec7nh b\u1ea1ch c\u1ea7u ti\u1ec1n t\u1ee7y c\u1ea5p t\u00ednh, HDAC trong b\u1ec7nh b\u1ea1ch c\u1ea7u t\u1ee7y c\u1ea5p t\u00ednh, SOX10 trong kh\u1ed1i u \u00e1c t\u00ednh v\u00e0 alpha-ketoglutarate trong ung th\u01b0 tuy\u1ebfn t\u1ee5y. Cu\u1ed1i c\u00f9ng, qu\u00e1 tr\u00ecnh truy\u1ec1n bi\u1ec7t h\u00f3a \u0111\u01b0\u1ee3c m\u00f4 t\u1ea3 r\u00f5 trong ung th\u01b0 bi\u1ec3u m\u00f4 tuy\u1ebfn \u1ed1ng t\u1ee5y (PDAC), trong \u0111\u00f3 c\u00e1c t\u1ebf b\u00e0o tuy\u1ebfn t\u1ee5y chuy\u1ec3n h\u00f3a th\u00e0nh ki\u1ec3u h\u00ecnh t\u1ebf b\u00e0o \u1ed1ng \u2013 qu\u00e1 tr\u00ecnh li\u00ean quan \u0111\u1ebfn hai y\u1ebfu t\u1ed1 phi\u00ean m\u00e3, PTF1A v\u00e0 MIST1.<\/p>\n

          \n
        • T\u00e1i l\u1eadp tr\u00ecnh bi\u1ec3u sinh kh\u00f4ng \u0111\u1ed9t bi\u1ebfn<\/li>\n<\/ul>\n

          Hanahan gi\u1edbi thi\u1ec7u thu\u1eadt ng\u1eef \u201ct\u00e1i l\u1eadp tr\u00ecnh bi\u1ec3u sinh kh\u00f4ng \u0111\u1ed9t bi\u1ebfn\u201d \u2013 m\u1ed9t c\u01a1 ch\u1ebf t\u00e1i l\u1eadp tr\u00ecnh b\u1ed9 gen \u0111\u1ed9c l\u1eadp d\u1ef1a tr\u00ean nh\u1eefng thay \u0111\u1ed5i \u0111\u01b0\u1ee3c \u0111i\u1ec1u h\u00f2a bi\u1ec3u sinh trong bi\u1ec3u hi\u1ec7n gen. C\u01a1 ch\u1ebf bi\u1ec3u sinh \u0111\u01b0\u1ee3c thi\u1ebft l\u1eadp t\u1ed1t n\u00e0y l\u00e0m trung gian cho s\u1ef1 ph\u00e1t tri\u1ec3n ph\u00f4i, bi\u1ec7t h\u00f3a m\u00f4 v\u00e0 c\u00e2n b\u1eb1ng n\u1ed9i m\u00f4i.<\/p>\n

          T\u00e1i l\u1eadp tr\u00ecnh bi\u1ec3u sinh kh\u00f4ng \u0111\u1ed9t bi\u1ebfn c\u00f3 th\u1ec3 x\u1ea3y ra th\u00f4ng qua c\u00e1c c\u01a1 ch\u1ebf m\u00f4i tr\u01b0\u1eddng vi m\u00f4, ch\u1eb3ng h\u1ea1n nh\u01b0 thi\u1ebfu oxy ho\u1eb7c chuy\u1ec3n t\u1eeb bi\u1ec3u m\u00f4 sang trung m\u00f4 (EMT). Do \u0111\u00f3, t\u00ecnh tr\u1ea1ng thi\u1ebfu oxy c\u00f3 th\u1ec3 d\u1eabn \u0111\u1ebfn qu\u00e1 tr\u00ecnh hypermethylation b\u1eb1ng c\u00e1ch gi\u1ea3m ho\u1ea1t \u0111\u1ed9ng c\u1ee7a TET demethylase. EMT ch\u1ecbu tr\u00e1ch nhi\u1ec7m l\u00e0m trung gian cho s\u1ef1 x\u00e2m l\u1ea5n c\u00f3 th\u1ec3 \u0111\u1ea3o ng\u01b0\u1ee3c c\u1ee7a t\u1ebf b\u00e0o ung th\u01b0 \u1edf bi\u00ean gi\u1edbi c\u1ee7a c\u00e1c kh\u1ed1i u r\u1eafn.<\/p>\n

          T\u00ednh kh\u00f4ng \u0111\u1ed3ng nh\u1ea5t c\u1ee7a quy \u0111\u1ecbnh bi\u1ec3u sinh \u0111\u00f3ng m\u1ed9t vai tr\u00f2 quan tr\u1ecdng trong vi\u1ec7c l\u1eadp tr\u00ecnh l\u1ea1i bi\u1ec3u sinh kh\u00f4ng \u0111\u1ed9t bi\u1ebfn. M\u1ed9t v\u00ed d\u1ee5 \u0111i\u1ec3n h\u00ecnh l\u00e0 tr\u00ecnh li\u00ean k\u1ebft histone H1.0, \u0111\u01b0\u1ee3c bi\u1ec3u hi\u1ec7n v\u00e0 \u1ee9c ch\u1ebf linh ho\u1ea1t trong c\u00e1c qu\u1ea7n th\u1ec3 t\u1ebf b\u00e0o ung th\u01b0 \u1edf m\u1ed9t s\u1ed1 lo\u1ea1i ung th\u01b0. C\u00e1c qu\u1ea7n th\u1ec3 t\u1ebf b\u00e0o ung th\u01b0 v\u1edbi H1.0 b\u1ecb \u1ee9c ch\u1ebf th\u1ec3 hi\u1ec7n c\u00e1c \u0111\u1eb7c t\u00ednh c\u1ee7a t\u1ebf b\u00e0o g\u1ed1c v\u00e0 kh\u1ea3 n\u0103ng b\u1eaft \u0111\u1ea7u ung th\u01b0 t\u0103ng l\u00ean; ch\u00fang c\u0169ng li\u00ean quan \u0111\u1ebfn ti\u00ean l\u01b0\u1ee3ng x\u1ea5u \u1edf b\u1ec7nh nh\u00e2n.<\/p>\n

            \n
          • H\u1ec7 vi sinh v\u1eadt \u0111a h\u00ecnh<\/li>\n<\/ul>\n

            S\u1ef1 bi\u1ebfn \u0111\u1ed5i \u0111a h\u00ecnh trong h\u1ec7 vi sinh v\u1eadt \u2013 t\u1eadp h\u1ee3p c\u00e1c vi sinh v\u1eadt c\u01b0 tr\u00fa trong c\u01a1 th\u1ec3 ch\u00fang ta \u2013 c\u00f3 th\u1ec3 \u1ea3nh h\u01b0\u1edfng \u0111\u00e1ng k\u1ec3 \u0111\u1ebfn ki\u1ec3u h\u00ecnh, s\u1ef1 ph\u00e1t tri\u1ec3n v\u00e0 ti\u1ebfn tri\u1ec3n c\u1ee7a b\u1ec7nh ung th\u01b0.<\/p>\n

            Hanahan x\u00e2y d\u1ef1ng tr\u01b0\u1eddng h\u1ee3p c\u00e1c qu\u1ea7n x\u00e3 vi sinh v\u1eadt \u0111a h\u00ecnh \u0111\u1ea1i di\u1ec7n cho m\u1ed9t \u0111\u1eb7c t\u00ednh cho ph\u00e9p ri\u00eang bi\u1ec7t t\u00e1c \u0111\u1ed9ng \u0111\u1ebfn vi\u1ec7c thu nh\u1eadn c\u00e1c d\u1ea5u hi\u1ec7u ung th\u01b0, t\u1ea1o \u0111i\u1ec1u ki\u1ec7n thu\u1eadn l\u1ee3i ho\u1eb7c b\u1ea3o v\u1ec7 ch\u1ed1ng l\u1ea1i c\u00e1c lo\u1ea1i ung th\u01b0 kh\u00e1c nhau. D\u00f2ng b\u1eb1ng ch\u1ee9ng quan tr\u1ecdng nh\u1ea5t li\u00ean quan \u0111\u1ebfn nghi\u00ean c\u1ee9u cho th\u1ea5y s\u1ef1 t\u1ed3n t\u1ea1i c\u1ee7a c\u00e1c vi sinh v\u1eadt b\u1ea3o v\u1ec7 ung th\u01b0 v\u00e0 th\u00fac \u0111\u1ea9y ung th\u01b0, c\u00f3 th\u1ec3 \u0111i\u1ec1u ch\u1ec9nh t\u1ef7 l\u1ec7 m\u1eafc v\u00e0 sinh b\u1ec7nh h\u1ecdc c\u1ee7a ung th\u01b0 ru\u1ed9t k\u1ebft. Ngo\u00e0i ra, th\u00e0nh ph\u1ea7n h\u1ec7 vi sinh v\u1eadt \u0111\u01b0\u1eddng ru\u1ed9t \u1ea3nh h\u01b0\u1edfng \u0111\u1ebfn h\u1ec7 th\u1ed1ng mi\u1ec5n d\u1ecbch, \u1ea3nh h\u01b0\u1edfng \u0111\u1ebfn kh\u1ea3 n\u0103ng mi\u1ec5n d\u1ecbch ch\u1ed1ng kh\u1ed1i u v\u00e0 \u0111\u00e1p \u1ee9ng v\u1edbi li\u1ec7u ph\u00e1p mi\u1ec5n d\u1ecbch \u1edf b\u1ec7nh nh\u00e2n u \u00e1c t\u00ednh.<\/p>\n

              \n
            • T\u1ebf b\u00e0o l\u00e3o h\u00f3a<\/li>\n<\/ul>\n

              L\u00e3o h\u00f3a t\u1ebf b\u00e0o l\u00e0 m\u1ed9t c\u01a1 ch\u1ebf b\u1eaft gi\u1eef chu k\u1ef3 t\u1ebf b\u00e0o kh\u00f4ng th\u1ec3 \u0111\u1ea3o ng\u01b0\u1ee3c, c\u00f3 kh\u1ea3 n\u0103ng \u0111\u01b0\u1ee3c ph\u00e1t tri\u1ec3n nh\u01b0 m\u1ed9t bi\u1ec7n ph\u00e1p b\u1ea3o v\u1ec7 \u0111\u1ec3 duy tr\u00ec c\u00e2n b\u1eb1ng n\u1ed9i m\u00f4. C\u01a1 ch\u1ebf n\u00e0y l\u00e0m t\u1eaft chu k\u1ef3 ph\u00e2n chia t\u1ebf b\u00e0o, b\u1eaft \u0111\u1ea7u thay \u0111\u1ed5i h\u00ecnh th\u00e1i v\u00e0 chuy\u1ec3n h\u00f3a t\u1ebf b\u00e0o, \u0111\u1ed3ng th\u1eddi k\u00edch ho\u1ea1t ki\u1ec3u h\u00ecnh b\u00e0i ti\u1ebft li\u00ean quan \u0111\u1ebfn tu\u1ed5i gi\u00e0 (SASP). L\u00e3o h\u00f3a c\u00f3 th\u1ec3 \u0111\u01b0\u1ee3c k\u00edch ho\u1ea1t b\u1edfi c\u00e1c k\u00edch th\u00edch b\u00ean ngo\u00e0i v\u00e0 b\u00ean trong kh\u00e1c nhau, bao g\u1ed3m thi\u1ebfu ch\u1ea5t dinh d\u01b0\u1ee1ng, t\u1ed5n th\u01b0\u01a1ng DNA, t\u1ed5n th\u01b0\u01a1ng c\u00e1c b\u00e0o quan v\u00e0 c\u01a1 s\u1edf h\u1ea1 t\u1ea7ng t\u1ebf b\u00e0o v\u00e0 m\u1ea5t c\u00e2n b\u1eb1ng t\u00edn hi\u1ec7u t\u1ebf b\u00e0o.<\/p>\n

              M\u1eb7c d\u00f9 c\u00e1c t\u1ebf b\u00e0o l\u00e3o h\u00f3a th\u01b0\u1eddng \u0111\u00f3ng vai tr\u00f2 b\u1ea3o v\u1ec7 ch\u1ed1ng l\u1ea1i kh\u1ed1i u, nh\u01b0ng trong m\u1ed9t s\u1ed1 tr\u01b0\u1eddng h\u1ee3p, ch\u00fang c\u00f3 th\u1ec3 k\u00edch th\u00edch s\u1ef1 ph\u00e1t tri\u1ec3n v\u00e0 ti\u1ebfn tri\u1ec3n c\u1ee7a kh\u1ed1i u. Do \u0111\u00f3, c\u00e1c cytokine SASP v\u00e0 c\u00e1c y\u1ebfu t\u1ed1 t\u0103ng tr\u01b0\u1edfng \u0111\u01b0\u1ee3c gi\u1ea3i ph\u00f3ng b\u1edfi c\u00e1c t\u1ebf b\u00e0o b\u1ea1ch c\u1ea7u c\u00f3 th\u1ec3 \u1ee9c ch\u1ebf kh\u1ed1i u ho\u1eb7c g\u00e2y ung th\u01b0 trong c\u00e1c b\u1ed1i c\u1ea3nh, lo\u1ea1i t\u1ebf b\u00e0o v\u00e0 kh\u1ed1i u kh\u00e1c nhau6. Trong b\u00e0i \u0111\u00e1nh gi\u00e1 m\u1edbi nh\u1ea5t, Hanahan \u0111\u01b0a ra m\u1ed9t \u0111\u1ec1 xu\u1ea5t thuy\u1ebft ph\u1ee5c v\u1ec1 vi\u1ec7c xem x\u00e9t b\u1ed5 sung c\u00e1c t\u1ebf b\u00e0o l\u00e3o h\u00f3a v\u00e0o c\u00e1c t\u1ebf b\u00e0o c\u00f3 ch\u1ee9c n\u0103ng quan tr\u1ecdng c\u1ee7a TME.<\/p>\n

              C\u00e1c d\u1ea5u hi\u1ec7u th\u01b0\u1eddng \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng \u0111\u1ec3 x\u00e1c \u0111\u1ecbnh c\u00e1c t\u1ebf b\u00e0o l\u00e3o h\u00f3a bao g\u1ed3m beta-galactosidase li\u00ean quan \u0111\u1ebfn l\u00e3o h\u00f3a v\u00e0 uPAR, m\u1ed9t trong nh\u1eefng d\u1ea5u \u1ea5n sinh h\u1ecdc \u0111\u01b0\u1ee3c m\u00f4 t\u1ea3 g\u1ea7n \u0111\u00e2y, \u0111\u01b0\u1ee3c t\u1ea1o ra r\u1ed9ng r\u00e3i trong qu\u00e1 tr\u00ecnh l\u00e3o h\u00f3a.<\/p>\n","protected":false},"excerpt":{"rendered":"

              Gi\u00e1o s\u01b0 Hanahan \u0111\u00e3 \u0111\u01b0a ra m\u1ed9t s\u01a1 \u0111\u1ed3 v\u1ec1 10 \u0111\u1eb7c t\u00ednh c\u1ee7a ung th\u01b0 \u0111\u1ec3 gi\u00fap \u0111\u1ecbnh ngh\u0129a v\u00e0 hi\u1ec3u r\u00f5 h\u01a1n v\u1ec1 b\u1ec7nh l\u00fd n\u00e0y. G\u1ea7n \u0111\u00e2y, c\u00e1c nh\u00e0 khoa h\u1ecdc \u0111\u00e3 \u0111\u1ec1 xu\u1ea5t th\u00eam v\u00e0o s\u01a1 \u0111\u1ed3 n\u00e0y 4 d\u1ea5u hi\u1ec7u m\u1edbi \u0111\u1ec3 m\u00f4 t\u1ea3 ch\u00ednh x\u00e1c h\u01a1n v\u1ec1 t\u00ednh ch\u1ea5t […]<\/p>\n","protected":false},"author":30,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[6,33],"tags":[],"yoast_head":"\n4 d\u1ea5u hi\u1ec7u \u0111\u1ec1 xu\u1ea5t th\u00eam v\u00e0o s\u01a1 \u0111\u1ed3 10 \u0111\u1eb7c t\u00ednh c\u01a1 b\u1ea3n c\u1ee7a ung th\u01b0 - Vinmec<\/title>\n<meta name=\"description\" content=\"B\u1ed1n d\u1ea5u hi\u1ec7u m\u1edbi c\u1ee7a ung th\u01b0: x\u00e1c l\u1eadp t\u00ednh d\u1ebbo ki\u1ec3u h\u00ecnh, t\u00e1i l\u1eadp tr\u00ecnh bi\u1ec3u sinh kh\u00f4ng \u0111\u1ed9t bi\u1ebfn, h\u1ec7 vi sinh v\u1eadt \u0111a h\u00ecnh v\u00e0 l\u00e3o h\u00f3a t\u1ebf b\u00e0o\" \/>\n<meta name=\"robots\" content=\"noindex, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"4 d\u1ea5u hi\u1ec7u \u0111\u1ec1 xu\u1ea5t th\u00eam v\u00e0o s\u01a1 \u0111\u1ed3 10 \u0111\u1eb7c t\u00ednh c\u01a1 b\u1ea3n c\u1ee7a ung th\u01b0 - Vinmec\" \/>\n<meta property=\"og:description\" content=\"B\u1ed1n d\u1ea5u hi\u1ec7u m\u1edbi c\u1ee7a ung th\u01b0: x\u00e1c l\u1eadp t\u00ednh d\u1ebbo ki\u1ec3u h\u00ecnh, t\u00e1i l\u1eadp tr\u00ecnh bi\u1ec3u sinh kh\u00f4ng \u0111\u1ed9t bi\u1ebfn, h\u1ec7 vi sinh v\u1eadt \u0111a h\u00ecnh v\u00e0 l\u00e3o h\u00f3a t\u1ebf b\u00e0o\" \/>\n<meta property=\"og:url\" content=\"http:\/\/noithathoaphat.in\/ctv\/index.php\/2023\/04\/23\/4-dau-hieu-moi-cua-benh-ung-thu\/\" \/>\n<meta property=\"og:site_name\" content=\"Vinmec\" \/>\n<meta property=\"article:published_time\" content=\"2023-04-22T17:19:11+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2023-04-22T17:43:24+00:00\" \/>\n<meta property=\"og:image\" content=\"http:\/\/noithathoaphat.in\/ctv\/wp-content\/uploads\/2023\/04\/41416_2019_723_Fig2_HTML-300x151.png\" \/>\n<meta name=\"author\" content=\"Truc Banh Thi Ngoc\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Truc Banh Thi Ngoc\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"8 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"http:\/\/noithathoaphat.in\/ctv\/index.php\/2023\/04\/23\/4-dau-hieu-moi-cua-benh-ung-thu\/\",\"url\":\"http:\/\/noithathoaphat.in\/ctv\/index.php\/2023\/04\/23\/4-dau-hieu-moi-cua-benh-ung-thu\/\",\"name\":\"4 d\u1ea5u hi\u1ec7u \u0111\u1ec1 xu\u1ea5t th\u00eam v\u00e0o s\u01a1 \u0111\u1ed3 10 \u0111\u1eb7c t\u00ednh c\u01a1 b\u1ea3n c\u1ee7a ung th\u01b0 - Vinmec\",\"isPartOf\":{\"@id\":\"http:\/\/noithathoaphat.in\/ctv\/#website\"},\"datePublished\":\"2023-04-22T17:19:11+00:00\",\"dateModified\":\"2023-04-22T17:43:24+00:00\",\"author\":{\"@id\":\"http:\/\/noithathoaphat.in\/ctv\/#\/schema\/person\/a2d772c72a4714248ee331af4cd70c9e\"},\"description\":\"B\u1ed1n d\u1ea5u hi\u1ec7u m\u1edbi c\u1ee7a ung th\u01b0: x\u00e1c l\u1eadp t\u00ednh d\u1ebbo ki\u1ec3u h\u00ecnh, t\u00e1i l\u1eadp tr\u00ecnh bi\u1ec3u sinh kh\u00f4ng \u0111\u1ed9t bi\u1ebfn, h\u1ec7 vi sinh v\u1eadt \u0111a h\u00ecnh v\u00e0 l\u00e3o h\u00f3a t\u1ebf b\u00e0o\",\"breadcrumb\":{\"@id\":\"http:\/\/noithathoaphat.in\/ctv\/index.php\/2023\/04\/23\/4-dau-hieu-moi-cua-benh-ung-thu\/#breadcrumb\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"http:\/\/noithathoaphat.in\/ctv\/index.php\/2023\/04\/23\/4-dau-hieu-moi-cua-benh-ung-thu\/\"]}]},{\"@type\":\"BreadcrumbList\",\"@id\":\"http:\/\/noithathoaphat.in\/ctv\/index.php\/2023\/04\/23\/4-dau-hieu-moi-cua-benh-ung-thu\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"http:\/\/noithathoaphat.in\/ctv\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"4 d\u1ea5u hi\u1ec7u \u0111\u1ec1 xu\u1ea5t th\u00eam v\u00e0o s\u01a1 \u0111\u1ed3 10 \u0111\u1eb7c t\u00ednh c\u01a1 b\u1ea3n c\u1ee7a ung th\u01b0\"}]},{\"@type\":\"WebSite\",\"@id\":\"http:\/\/noithathoaphat.in\/ctv\/#website\",\"url\":\"http:\/\/noithathoaphat.in\/ctv\/\",\"name\":\"Vinmec\",\"description\":\"H\u1ec7 th\u1ed1ng Y t\u1ebf Vinmec\",\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"http:\/\/noithathoaphat.in\/ctv\/?s={search_term_string}\"},\"query-input\":\"required name=search_term_string\"}],\"inLanguage\":\"en-US\"},{\"@type\":\"Person\",\"@id\":\"http:\/\/noithathoaphat.in\/ctv\/#\/schema\/person\/a2d772c72a4714248ee331af4cd70c9e\",\"name\":\"Truc Banh Thi Ngoc\",\"image\":{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"http:\/\/noithathoaphat.in\/ctv\/#\/schema\/person\/image\/\",\"url\":\"http:\/\/1.gravatar.com\/avatar\/de02241dcd64d179907ecb2b3b3726ed?s=96&d=mm&r=g\",\"contentUrl\":\"http:\/\/1.gravatar.com\/avatar\/de02241dcd64d179907ecb2b3b3726ed?s=96&d=mm&r=g\",\"caption\":\"Truc Banh Thi Ngoc\"},\"url\":\"http:\/\/noithathoaphat.in\/ctv\/index.php\/author\/trucbanhctumpgmail-com\/\"}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"4 d\u1ea5u hi\u1ec7u \u0111\u1ec1 xu\u1ea5t th\u00eam v\u00e0o s\u01a1 \u0111\u1ed3 10 \u0111\u1eb7c t\u00ednh c\u01a1 b\u1ea3n c\u1ee7a ung th\u01b0 - Vinmec","description":"B\u1ed1n d\u1ea5u hi\u1ec7u m\u1edbi c\u1ee7a ung th\u01b0: x\u00e1c l\u1eadp t\u00ednh d\u1ebbo ki\u1ec3u h\u00ecnh, t\u00e1i l\u1eadp tr\u00ecnh bi\u1ec3u sinh kh\u00f4ng \u0111\u1ed9t bi\u1ebfn, h\u1ec7 vi sinh v\u1eadt \u0111a h\u00ecnh v\u00e0 l\u00e3o h\u00f3a t\u1ebf b\u00e0o","robots":{"index":"noindex","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"og_locale":"en_US","og_type":"article","og_title":"4 d\u1ea5u hi\u1ec7u \u0111\u1ec1 xu\u1ea5t th\u00eam v\u00e0o s\u01a1 \u0111\u1ed3 10 \u0111\u1eb7c t\u00ednh c\u01a1 b\u1ea3n c\u1ee7a ung th\u01b0 - Vinmec","og_description":"B\u1ed1n d\u1ea5u hi\u1ec7u m\u1edbi c\u1ee7a ung th\u01b0: x\u00e1c l\u1eadp t\u00ednh d\u1ebbo ki\u1ec3u h\u00ecnh, t\u00e1i l\u1eadp tr\u00ecnh bi\u1ec3u sinh kh\u00f4ng \u0111\u1ed9t bi\u1ebfn, h\u1ec7 vi sinh v\u1eadt \u0111a h\u00ecnh v\u00e0 l\u00e3o h\u00f3a t\u1ebf b\u00e0o","og_url":"http:\/\/noithathoaphat.in\/ctv\/index.php\/2023\/04\/23\/4-dau-hieu-moi-cua-benh-ung-thu\/","og_site_name":"Vinmec","article_published_time":"2023-04-22T17:19:11+00:00","article_modified_time":"2023-04-22T17:43:24+00:00","og_image":[{"url":"http:\/\/noithathoaphat.in\/ctv\/wp-content\/uploads\/2023\/04\/41416_2019_723_Fig2_HTML-300x151.png"}],"author":"Truc Banh Thi Ngoc","twitter_card":"summary_large_image","twitter_misc":{"Written by":"Truc Banh Thi Ngoc","Est. reading time":"8 minutes"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"WebPage","@id":"http:\/\/noithathoaphat.in\/ctv\/index.php\/2023\/04\/23\/4-dau-hieu-moi-cua-benh-ung-thu\/","url":"http:\/\/noithathoaphat.in\/ctv\/index.php\/2023\/04\/23\/4-dau-hieu-moi-cua-benh-ung-thu\/","name":"4 d\u1ea5u hi\u1ec7u \u0111\u1ec1 xu\u1ea5t th\u00eam v\u00e0o s\u01a1 \u0111\u1ed3 10 \u0111\u1eb7c t\u00ednh c\u01a1 b\u1ea3n c\u1ee7a ung th\u01b0 - Vinmec","isPartOf":{"@id":"http:\/\/noithathoaphat.in\/ctv\/#website"},"datePublished":"2023-04-22T17:19:11+00:00","dateModified":"2023-04-22T17:43:24+00:00","author":{"@id":"http:\/\/noithathoaphat.in\/ctv\/#\/schema\/person\/a2d772c72a4714248ee331af4cd70c9e"},"description":"B\u1ed1n d\u1ea5u hi\u1ec7u m\u1edbi c\u1ee7a ung th\u01b0: x\u00e1c l\u1eadp t\u00ednh d\u1ebbo ki\u1ec3u h\u00ecnh, t\u00e1i l\u1eadp tr\u00ecnh bi\u1ec3u sinh kh\u00f4ng \u0111\u1ed9t bi\u1ebfn, h\u1ec7 vi sinh v\u1eadt \u0111a h\u00ecnh v\u00e0 l\u00e3o h\u00f3a t\u1ebf b\u00e0o","breadcrumb":{"@id":"http:\/\/noithathoaphat.in\/ctv\/index.php\/2023\/04\/23\/4-dau-hieu-moi-cua-benh-ung-thu\/#breadcrumb"},"inLanguage":"en-US","potentialAction":[{"@type":"ReadAction","target":["http:\/\/noithathoaphat.in\/ctv\/index.php\/2023\/04\/23\/4-dau-hieu-moi-cua-benh-ung-thu\/"]}]},{"@type":"BreadcrumbList","@id":"http:\/\/noithathoaphat.in\/ctv\/index.php\/2023\/04\/23\/4-dau-hieu-moi-cua-benh-ung-thu\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"http:\/\/noithathoaphat.in\/ctv\/"},{"@type":"ListItem","position":2,"name":"4 d\u1ea5u hi\u1ec7u \u0111\u1ec1 xu\u1ea5t th\u00eam v\u00e0o s\u01a1 \u0111\u1ed3 10 \u0111\u1eb7c t\u00ednh c\u01a1 b\u1ea3n c\u1ee7a ung th\u01b0"}]},{"@type":"WebSite","@id":"http:\/\/noithathoaphat.in\/ctv\/#website","url":"http:\/\/noithathoaphat.in\/ctv\/","name":"Vinmec","description":"H\u1ec7 th\u1ed1ng Y t\u1ebf Vinmec","potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"http:\/\/noithathoaphat.in\/ctv\/?s={search_term_string}"},"query-input":"required name=search_term_string"}],"inLanguage":"en-US"},{"@type":"Person","@id":"http:\/\/noithathoaphat.in\/ctv\/#\/schema\/person\/a2d772c72a4714248ee331af4cd70c9e","name":"Truc Banh Thi Ngoc","image":{"@type":"ImageObject","inLanguage":"en-US","@id":"http:\/\/noithathoaphat.in\/ctv\/#\/schema\/person\/image\/","url":"http:\/\/1.gravatar.com\/avatar\/de02241dcd64d179907ecb2b3b3726ed?s=96&d=mm&r=g","contentUrl":"http:\/\/1.gravatar.com\/avatar\/de02241dcd64d179907ecb2b3b3726ed?s=96&d=mm&r=g","caption":"Truc Banh Thi Ngoc"},"url":"http:\/\/noithathoaphat.in\/ctv\/index.php\/author\/trucbanhctumpgmail-com\/"}]}},"_links":{"self":[{"href":"http:\/\/noithathoaphat.in\/ctv\/index.php\/wp-json\/wp\/v2\/posts\/20515"}],"collection":[{"href":"http:\/\/noithathoaphat.in\/ctv\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"http:\/\/noithathoaphat.in\/ctv\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"http:\/\/noithathoaphat.in\/ctv\/index.php\/wp-json\/wp\/v2\/users\/30"}],"replies":[{"embeddable":true,"href":"http:\/\/noithathoaphat.in\/ctv\/index.php\/wp-json\/wp\/v2\/comments?post=20515"}],"version-history":[{"count":3,"href":"http:\/\/noithathoaphat.in\/ctv\/index.php\/wp-json\/wp\/v2\/posts\/20515\/revisions"}],"predecessor-version":[{"id":27140,"href":"http:\/\/noithathoaphat.in\/ctv\/index.php\/wp-json\/wp\/v2\/posts\/20515\/revisions\/27140"}],"wp:attachment":[{"href":"http:\/\/noithathoaphat.in\/ctv\/index.php\/wp-json\/wp\/v2\/media?parent=20515"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"http:\/\/noithathoaphat.in\/ctv\/index.php\/wp-json\/wp\/v2\/categories?post=20515"},{"taxonomy":"post_tag","embeddable":true,"href":"http:\/\/noithathoaphat.in\/ctv\/index.php\/wp-json\/wp\/v2\/tags?post=20515"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}