{"id":18469,"date":"2023-04-15T23:13:56","date_gmt":"2023-04-15T16:13:56","guid":{"rendered":"http:\/\/noithathoaphat.in\/ctv\/?p=18469"},"modified":"2023-04-17T14:25:30","modified_gmt":"2023-04-17T07:25:30","slug":"hieu-qua-phoi-hop-tra-xanh-va-tamoxifen-trong-dieu-tri-ung-thu-vu","status":"publish","type":"post","link":"http:\/\/noithathoaphat.in\/ctv\/index.php\/2023\/04\/15\/hieu-qua-phoi-hop-tra-xanh-va-tamoxifen-trong-dieu-tri-ung-thu-vu\/","title":{"rendered":"Hi\u1ec7u qu\u1ea3 ph\u1ed1i h\u1ee3p tr\u00e0 xanh v\u00e0 Tamoxifen trong \u0111i\u1ec1u tr\u1ecb ung th\u01b0 v\u00fa"},"content":{"rendered":"

Ung th\u01b0 v\u00fa l\u00e0 m\u1ed9t trong nh\u1eefng lo\u1ea1i ung th\u01b0 ph\u1ed5 bi\u1ebfn \u1edf ph\u1ee5 n\u1eef tr\u00ean to\u00e0n th\u1ebf gi\u1edbi. Tuy v\u1eady vi\u1ec7c \u0111i\u1ec1u tr\u1ecb ung th\u01b0 v\u00fa v\u1eabn c\u00f2n g\u1eb7p nhi\u1ec1u th\u00e1ch th\u1ee9c, \u0111\u1eb7c bi\u1ec7t trong vi\u1ec7c t\u00ecm ki\u1ebfm c\u00e1c ph\u01b0\u01a1ng ph\u00e1p \u0111i\u1ec1u tr\u1ecb hi\u1ec7u qu\u1ea3 v\u00e0 an to\u00e0n. Trong nh\u1eefng n\u0103m g\u1ea7n \u0111\u00e2y, nhi\u1ec1u nghi\u00ean c\u1ee9u \u0111\u00e3 ch\u1ee9ng minh r\u1eb1ng vi\u1ec7c ph\u1ed1i h\u1ee3p s\u1eed d\u1ee5ng tr\u00e0 xanh v\u00e0 Tamoxifen c\u00f3 th\u1ec3 l\u00e0 m\u1ed9t gi\u1ea3i ph\u00e1p ti\u1ec1m n\u0103ng trong \u0111i\u1ec1u tr\u1ecb ung th\u01b0 v\u00fa<\/strong><\/p>\n

1.Gi\u1edbi thi\u1ec7u\u00a0<\/strong><\/h2>\n

Tr\u00e0 xanh \u0111\u01b0\u1ee3c l\u00e0m t\u1eeb l\u00e1 c\u1ee7a c\u00e2y b\u1ee5i th\u01b0\u1eddng xanh thu\u1ed9c h\u1ecd th\u1ef1c v\u1eadt Theaceae v\u00e0 chi Camellia sinensis. Ban \u0111\u1ea7u c\u00e2y tr\u00e0 xanh ch\u1ec9 \u0111\u01b0\u1ee3c tr\u1ed3ng \u1edf Trung Qu\u1ed1c nh\u1eefng hi\u1ec7n nay tr\u00e0 xanh \u0111\u00e3 c\u00f3 m\u1eb7t \u1edf nhi\u1ec1u qu\u1ed1c gia khu v\u1ef1c Ch\u00e2u \u00c1. L\u00e1 c\u1ee7a tr\u00e0 xanh kh\u00f4ng tr\u1ea3i qua qu\u00e1 tr\u00ecnh oxy h\u00f3a n\u00ean c\u00f3 h\u01b0\u01a1ng v\u1ecb kh\u00e1c bi\u1ec7t so v\u1edbi tr\u00e0 \u0111en. Tr\u00e0 xanh th\u01b0\u1eddng \u00edt ng\u1ecdt v\u00e0 \u0111\u1eadm \u0111\u00e0 t\u00f9y thu\u1ed9c v\u00e0o lo\u1ea1i cho h\u01b0\u01a1ng v\u1ecb kh\u00e1c nhau. Tr\u00e0 xanh \u0111\u01b0\u1ee3c cho l\u00e0 c\u00f3 nhi\u1ec1u l\u1ee3i \u00edch cho s\u1ee9c kh\u1ecfe, \u0111\u1eb7c bi\u1ec7t l\u00e0 trong vi\u1ec7c ng\u0103n ng\u1eeba v\u00e0 \u0111i\u1ec1u tr\u1ecb m\u1ed9t s\u1ed1 b\u1ec7nh l\u00fd nh\u01b0 ung th\u01b0, b\u1ec7nh tim v\u00e0 ti\u1ec3u \u0111\u01b0\u1eddng.<\/span><\/p>\n

\"L\u00e1
L\u00e1 tr\u00e0 xanh<\/figcaption><\/figure>\n

Ung th\u01b0 \u0111\u01b0\u1ee3c bi\u1ebft \u0111\u1ebfn l\u00e0 b\u1ec7nh l\u00fd \u0111\u00e1ng s\u1ee3 v\u00e0 nguy hi\u1ec3m cho s\u1ee9c kh\u1ecfe con ng\u01b0\u1eddi. Ung th\u01b0 di\u1ec5n ra khi c\u00e1c t\u1ebf b\u00e0o trong c\u01a1 th\u1ec3 ph\u00e1t tri\u1ec3n kh\u00f4ng ki\u1ec3m so\u00e1t v\u00e0 kh\u00f4ng th\u1ec3 b\u1ecb t\u1ef1 \u0111\u1ed9ng gi\u1ebft ch\u1ebft b\u1edfi h\u1ec7 th\u1ed1ng mi\u1ec5n d\u1ecbch c\u1ee7a c\u01a1 th\u1ec3. C\u00e1c t\u1ebf b\u00e0o ung th\u01b0 c\u00f3 kh\u1ea3 n\u0103ng x\u00e2m chi\u1ebfm v\u00e0 ph\u00e1 h\u1ee7y c\u00e1c t\u1ebf b\u00e0o kh\u00e1c trong c\u01a1 th\u1ec3, g\u00e2y ra c\u00e1c v\u1ea5n \u0111\u1ec1 s\u1ee9c kh\u1ecfe nghi\u00eam tr\u1ecdng v\u00e0 c\u00f3 th\u1ec3 d\u1eabn \u0111\u1ebfn t\u1eed vong. Ung th\u01b0 v\u00fa l\u00e0 lo\u1ea1i ung ung th\u01b0 ph\u1ed5 bi\u1ebfn nh\u1ea5t \u1edf ph\u1ee5 n\u1eef tr\u00ean to\u00e0n th\u1ebf gi\u1edbi. \u0110\u00e2y l\u00e0 m\u1ed9t lo\u1ea1i ung th\u01b0 ph\u00e1t tri\u1ec3n t\u1eeb c\u00e1c t\u1ebf b\u00e0o trong tuy\u1ebfn v\u00fa ho\u1eb7c c\u00e1c m\u00f4 xung quanh<\/span><\/p>\n

\"Ung
Ung th\u01b0<\/figcaption><\/figure>\n
\"Ung
Ung th\u01b0 v\u00fa<\/figcaption><\/figure>\n

Hi\u1ec7n nay, c\u00f3 nhi\u1ec1u ph\u01b0\u01a1ng ph\u00e1p \u0111i\u1ec1u tr\u1ecb ung th\u01b0 \u0111\u01b0\u1ee3c \u00e1p d\u1ee5ng, bao g\u1ed3m ph\u1eabu thu\u1eadt, h\u00f3a tr\u1ecb, x\u1ea1 tr\u1ecb v\u00e0 \u0111i\u1ec1u tr\u1ecb b\u1eb1ng thu\u1ed1c. Trong \u0111\u00f3, Tamoxifen<\/a> th\u01b0\u1eddng \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng \u0111\u1ec3 \u0111i\u1ec1u tr\u1ecb ung th\u01b0 v\u00fa \u1edf ph\u1ee5 n\u1eef b\u1edfi hi\u1ec7u qu\u1ea3 t\u1ed1i \u01b0u c\u1ee7a n\u00f3<\/span><\/p>\n

\"Tamoxifen\"
Tamoxifen<\/figcaption><\/figure>\n

2.T\u00e1c d\u1ee5ng ri\u00eang l\u1ebb c\u1ee7a Tamoxifen v\u00e0 tr\u00e0 xanh trong ung th\u01b0 v\u00fa<\/h2>\n

2.1 C\u01a1 ch\u1ebf ho\u1ea1t \u0111\u1ed9ng c\u1ee7a Tamoxifen trong ung th\u01b0 v\u00fa<\/span><\/h3>\n

Tamoxifen l\u00e0 li\u1ec7u ph\u00e1p hormon \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng \u0111i\u1ec1u tr\u1ecb ung th\u01b0 v\u00fa d\u1ef1a v\u00e0o c\u01a1 ch\u1ebf ch\u00ednh ng\u0103n c\u1ea3n ho\u1ea1t \u0111\u1ed9ng c\u1ee7a Estrogen trong v\u00fa theo c\u01a1 ch\u1ebf t\u00e1c d\u1ee5ng k\u00e9p: (1) Tamoxifen c\u1ea1nh tranh v\u1edbi 17\u03b2-estradiol (E2) t\u1ea1i v\u1ecb tr\u00ed th\u1ee5 th\u1ec3 v\u00e0 ng\u0103n ch\u1eb7n vai tr\u00f2 th\u00fac \u0111\u1ea9y c\u1ee7a E2 trong ung th\u01b0 v\u00fa, (2) Tamoxifen l\u00e0 t\u00e1c nh\u00e2n h\u00f3a h\u1ecdc c\u1ea1nh tranh hi\u1ec7u qu\u1ea3 cho qu\u00e1 tr\u00ecnh epoxy h\u00f3a gi\u00fap c\u1ea3n tr\u1edf s\u1ef1 h\u00ecnh th\u00e0nh E2. Quan tr\u1ecdng nh\u1ea5t, Tamoxifen c\u00f3 th\u1ec3 l\u00e0m gi\u1ea3m 50% nguy c\u01a1 t\u00e1i ph\u00e1t ung th\u01b0 v\u00fa \u1edf ng\u01b0\u1eddi ti\u1ec1n m\u00e3n kinh v\u00e0 gi\u1ea3m ph\u1ea7n tr\u0103m c\u01a1 h\u1ed9i sau l\u1ea7n \u0111i\u1ec1u tr\u1ecb \u0111\u1ea7u ti\u00ean trong v\u00f2ng 10 n\u0103m<\/span><\/p>\n

2.2 C\u01a1 ch\u1ebf ho\u1ea1t \u0111\u1ed9ng c\u1ee7a tr\u00e0 xanh trong ung th\u01b0 v\u00fa\u00a0<\/span><\/h3>\n

Trong tr\u00e0 xanh, ho\u1ea1t ch\u1ea5t Epigallocatechin-3-gallate (EGCG) \u0111\u00e3 \u0111\u01b0\u1ee3c ch\u1ee9ng minh l\u00e0 c\u00f3 t\u00e1c d\u1ee5ng \u1ee9c ch\u1ebf s\u1ef1 ph\u00e1t tri\u1ec3n kh\u1ed1i u v\u00e0 s\u1ef1 h\u00ecnh th\u00e0nh m\u1ea1ch c\u1ee7a ung th\u01b0 v\u00fa d\u01b0\u01a1ng t\u00ednh v\u1edbi th\u1ee5 th\u1ec3 Estrogen (ER+) m\u00e0 kh\u00f4ng \u1ea3nh h\u01b0\u1edfng \u0111\u1ebfn s\u1ef1 ph\u00e1t tri\u1ec3n c\u1ee7a c\u00e1c t\u1ebf b\u00e0o b\u00ecnh th\u01b0\u1eddng. EGCG \u1ee9c ch\u1ebf s\u1ef1 ph\u00e1t tri\u1ec3n kh\u1ed1i u, t\u0103ng sinh, di c\u01b0 v\u00e0 h\u00ecnh th\u00e0nh m\u1ea1ch c\u1ee7a ung th\u01b0 v\u00fa. Trong nhi\u1ec1u nghi\u00ean c\u1ee9u, EGCG \u0111\u00e3 \u0111\u01b0\u1ee3c b\u00e1o c\u00e1o l\u00e0 c\u00f3 t\u00e1c d\u1ee5ng \u1ee9c ch\u1ebf m\u1ed9t s\u1ed1 enzyme nh\u01b0 protein kinase li\u00ean quan \u0111\u1ebfn vi\u1ec7c ng\u1eebng chu k\u1ef3 t\u1ebf b\u00e0o \u1edf pha G1<\/span><\/p>\n

3.Ph\u1ed1i h\u1ee3p Tamoxifen v\u00e0 tr\u00e0 xanh trong \u0111i\u1ec1u tr\u1ecb ung th\u01b0 v\u00fa<\/h2>\n

Vi\u1ec7c s\u1eed d\u1ee5ng Tamoxifen v\u00e0 tr\u00e0 xanh c\u00f9ng l\u00fac trong \u0111i\u1ec1u tr\u1ecb ung th\u01b0 v\u00fa \u0111\u01b0\u1ee3c xem l\u00e0 m\u1ed9t ph\u01b0\u01a1ng ph\u00e1p ti\u1ec1m n\u0103ng \u0111\u1ec3 c\u1ea3i thi\u1ec7n hi\u1ec7u qu\u1ea3 \u0111i\u1ec1u tr\u1ecb v\u00e0 gi\u1ea3m thi\u1ec3u t\u00e1c d\u1ee5ng ph\u1ee5 c\u1ee7a Tamoxifen. C\u1ee5 th\u1ec3, tuy Tamoxifen l\u00e0 m\u1ed9t lo\u1ea1i thu\u1ed1c \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng trong \u0111i\u1ec1u tr\u1ecb ung th\u01b0 v\u00fa ph\u1ee5 thu\u1ed9c v\u00e0o hormon Estrogen, Tamoxifen c\u00f3 th\u1ec3 g\u00e2y ra nh\u1eefng t\u00e1c d\u1ee5ng ph\u1ee5<\/a>\u00a0 nh\u01b0 \u0111au \u0111\u1ea7u, bu\u1ed3n n\u00f4n, s\u01b0ng ng\u1ef1c, m\u1ea5t ng\u1ee7 v\u00e0 t\u0103ng nguy c\u01a1 ung th\u01b0 t\u1eed cung. Khi ph\u1ed1i h\u1ee3p s\u1eed d\u1ee5ng Tamoxifen v\u00e0 tr\u00e0 xanh, nhi\u1ec1u nghi\u00ean c\u1ee9u \u0111\u00e3 cho th\u1ea5y t\u00e1c d\u1ee5ng v\u01b0\u1ee3t tr\u1ed9i h\u01a1n g\u1ea5p 10-15 l\u1ea7n trong vi\u1ec7c c\u1ea3i thi\u1ec7n hi\u1ec7u qu\u1ea3 \u0111i\u1ec1u tr\u1ecb ung th\u01b0 v\u00fa v\u00e0 gi\u1ea3m thi\u1ec3u t\u00e1c d\u1ee5ng ph\u1ee5 khi Catechin trong tr\u00e0 xanh t\u01b0\u01a1ng t\u00e1c v\u1edbi Tamoxifen so v\u1edbi s\u1eed d\u1ee5ng thu\u1ed1c ch\u1ed1ng ung th\u01b0 \u0111\u01a1n \u0111\u1ed9c. S\u1ef1 k\u1ebft h\u1ee3p gi\u1eefa EGCG v\u00e0 Tamoxifen g\u00e2y ra qu\u00e1 tr\u00ecnh ch\u1ebft t\u1ebf b\u00e0o theo chu tr\u00ecnh trong c\u00e1c t\u1ebf b\u00e0o PC-9 m\u1ea1nh h\u01a1n khi s\u1eed d\u1ee5ng ri\u00eang l\u1ebb.Ngo\u00e0i ra ph\u1ed1i h\u1ee3p c\u00f2n g\u00e2y ra s\u1ef1 \u1ee9c ch\u1ebf gi\u1ea3i ph\u00f3ng TNF-\u03b1 t\u1eeb c\u00e1c t\u1ebf b\u00e0o BALB\/3T3 t\u1eeb \u0111\u00f3 \u1ee9c ch\u1ebf s\u1ef1 ph\u00e1t tri\u1ec3n c\u1ee7a t\u1ebf b\u00e0o trong d\u00f2ng t\u1ebf b\u00e0o ung th\u01b0 v\u00fa MCF-7 \u1edf ng\u01b0\u1eddi. EGCG trong tr\u00e0 xanh khi d\u00f9ng c\u00f9ng l\u00fac v\u1edbi Tamoxifen \u0111\u01b0\u1ee3c nghi\u00ean c\u1ee9u g\u00e2y \u1ee9c ch\u1ebf t\u0103ng sinh c\u1ee7a c\u00e1c t\u1ebf b\u00e0o ung th\u01b0 v\u00fa d\u01b0\u01a1ng t\u00ednh v\u1edbi ER (g\u1ed3m d\u00f2ng t\u1ebf b\u00e0o ZR-75-1 v\u00e0 T-47D) \u0111\u1ed3ng th\u1eddi \u1ee9c ch\u1ebf s\u1ef1 ph\u00e1t tri\u1ec3n c\u1ee7a d\u00f2ng t\u1ebf b\u00e0o ngo\u1ea1i lai MDA-MB-231 m\u1ea1nh h\u01a1n so v\u1edbi s\u1eed d\u1ee5ng thu\u1ed1c \u0111\u01a1n thu\u1ea7n<\/span><\/p>\n

4.L\u01b0u \u00fd khi ph\u1ed1i h\u1ee3p Tamoxifen v\u00e0 tr\u00e0 xanh trong \u0111i\u1ec1u tr\u1ecb ung th\u01b0 v\u00fa<\/h2>\n

Li\u1ec1u l\u01b0\u1ee3ng: C\u1ea7n tu\u00e2n th\u1ee7 \u0111\u00fang li\u1ec1u l\u01b0\u1ee3ng \u0111\u01b0\u1ee3c ch\u1ec9 \u0111\u1ecbnh b\u1edfi b\u00e1c s\u0129. Vi\u1ec7c s\u1eed d\u1ee5ng qu\u00e1 li\u1ec1u Tamoxifen c\u00f3 th\u1ec3 g\u00e2y ra t\u00e1c d\u1ee5ng ph\u1ee5 nghi\u00eam tr\u1ecdng nh\u01b0 \u0111au b\u1ee5ng, ti\u00eau ch\u1ea3y, n\u00f4n m\u1eeda, s\u1ed1t, m\u1ea5t tr\u00ed nh\u1edb v\u00e0 \u0111\u1ed9t qu\u1ef5. Tr\u00e0 xanh c\u0169ng c\u00f3 th\u1ec3 g\u00e2y ra t\u00e1c d\u1ee5ng ph\u1ee5 n\u1ebfu s\u1eed d\u1ee5ng qu\u00e1 li\u1ec1u, nh\u01b0ng th\u01b0\u1eddng l\u00e0 nh\u1eb9 nh\u01b0 bu\u1ed3n n\u00f4n, \u0111au \u0111\u1ea7u ho\u1eb7c kh\u00f3 ng\u1ee7.<\/span><\/p>\n

Th\u1eddi gian s\u1eed d\u1ee5ng: C\u1ea7n s\u1eed d\u1ee5ng Tamoxifen v\u00e0 tr\u00e0 xanh theo h\u01b0\u1edbng d\u1eabn c\u1ee7a b\u00e1c s\u0129 v\u00e0 kh\u00f4ng n\u00ean d\u1eebng thu\u1ed1c \u0111\u1ed9t ng\u1ed9t. Vi\u1ec7c s\u1eed d\u1ee5ng Tamoxifen trong th\u1eddi gian d\u00e0i c\u00f3 th\u1ec3 g\u00e2y ra t\u00e1c d\u1ee5ng ph\u1ee5 kh\u00e1c nh\u01b0 t\u0103ng nguy c\u01a1 ung th\u01b0 t\u1eed cung hay ung th\u01b0 v\u00fa t\u1ebf b\u00e0o th\u1ee5 th\u1ec3 \u00e2m t\u00ednh. Tr\u00e0 xanh c\u0169ng c\u00f3 th\u1ec3 g\u00e2y ra t\u00e1c d\u1ee5ng ph\u1ee5 n\u1ebfu s\u1eed d\u1ee5ng l\u00e2u d\u00e0i v\u00e0 \u0111\u1eb7c bi\u1ec7t l\u00e0 trong tr\u01b0\u1eddng h\u1ee3p s\u1eed d\u1ee5ng ch\u01b0a \u0111\u00fang c\u00e1ch<\/span><\/p>\n

T\u01b0\u01a1ng t\u00e1c thu\u1ed1c kh\u00e1c: Tamoxifen c\u00f3 th\u1ec3 t\u01b0\u01a1ng t\u00e1c v\u1edbi m\u1ed9t s\u1ed1 lo\u1ea1i thu\u1ed1c nh\u01b0 thu\u1ed1c ch\u1ed1ng \u0111\u00f4ng, thu\u1ed1c ch\u1ed1ng tr\u1ea7m c\u1ea3m IMAO. Do \u0111\u00f3, c\u1ea7n th\u00f4ng b\u00e1o v\u1edbi b\u00e1c s\u0129 v\u1ec1 c\u00e1c lo\u1ea1i thu\u1ed1c kh\u00e1c \u0111ang s\u1eed d\u1ee5ng \u0111\u1ec3 tr\u00e1nh t\u01b0\u01a1ng t\u00e1c kh\u00f4ng mong mu\u1ed1n.<\/span><\/p>\n

H\u00e3y li\u00ean h\u1ec7 v\u1edbi ch\u00fang t\u00f4i Hotline Vinmec<\/a> n\u1ebfu b\u1ea1n mu\u1ed1n \u0111\u1eb7t l\u1ecbch kh\u00e1m ho\u1eb7c c\u00f3 b\u1ea5t k\u1ef3 th\u1eafc m\u1eafc n\u00e0o<\/p>\n

Ngu\u1ed3n: T\u1ed5ng h\u1ee3p<\/p>\n","protected":false},"excerpt":{"rendered":"

Ung th\u01b0 v\u00fa l\u00e0 m\u1ed9t trong nh\u1eefng lo\u1ea1i ung th\u01b0 ph\u1ed5 bi\u1ebfn \u1edf ph\u1ee5 n\u1eef tr\u00ean to\u00e0n th\u1ebf gi\u1edbi. Tuy v\u1eady vi\u1ec7c \u0111i\u1ec1u tr\u1ecb ung th\u01b0 v\u00fa v\u1eabn c\u00f2n g\u1eb7p nhi\u1ec1u th\u00e1ch th\u1ee9c, \u0111\u1eb7c bi\u1ec7t trong vi\u1ec7c t\u00ecm ki\u1ebfm c\u00e1c ph\u01b0\u01a1ng ph\u00e1p \u0111i\u1ec1u tr\u1ecb hi\u1ec7u qu\u1ea3 v\u00e0 an to\u00e0n. Trong nh\u1eefng n\u0103m g\u1ea7n \u0111\u00e2y, nhi\u1ec1u […]<\/p>\n","protected":false},"author":54,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[12,32],"tags":[3],"yoast_head":"\nHi\u1ec7u qu\u1ea3 ph\u1ed1i h\u1ee3p tr\u00e0 xanh v\u00e0 Tamoxifen trong \u0111i\u1ec1u tr\u1ecb ung th\u01b0 v\u00fa<\/title>\n<meta name=\"description\" content=\"S\u1ef1 k\u1ebft h\u1ee3p gi\u1eefa tr\u00e0 xanh v\u00e0 Tamoxifen trong \u0111i\u1ec1u tr\u1ecb ung th\u01b0 v\u00fa l\u00e0 gi\u1ea3i ph\u00e1p \u0111\u01b0\u1ee3c k\u1ef3 v\u1ecdng t\u0103ng c\u01b0\u1eddng hi\u1ec7u qu\u1ea3 v\u00e0 gi\u1ea3m t\u00e1c d\u1ee5ng ph\u1ee5\" \/>\n<meta name=\"robots\" content=\"noindex, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Hi\u1ec7u 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